{
"METABOLOMICS WORKBENCH":{"STUDY_ID":"ST002993","ANALYSIS_ID":"AN004917","VERSION":"1","CREATED_ON":"November 28, 2023, 5:50 pm"},

"PROJECT":{"PROJECT_TITLE":"Identifying subgroups of childhood obesity by using multiplatform metabotyping","PROJECT_SUMMARY":"Obesity results from an interplay between genetic predisposition and environmental factors such as diet, physical activity, culture, and socioeconomic status. Personalized treatments for obesity would be optimal, thus necessitating the identification of individual characteristics to improve the effectiveness of therapies. For example, genetic impairment of the leptin-melanocortin pathway can result in rare cases of severe early-onset obesity. Metabolomics has the potential to distinguish between a healthy and obese status; however, differentiating subsets of individuals within the obesity spectrum remains challenging. Factor analysis can integrate patient features from diverse sources, allowing an accurate subclassification of individuals. This study presents a workflow to identify metabotypes, particularly when routine clinical studies fail in patient categorization. 110 children with obesity (BMI > +2 SDS) genotyped for nine genes involved in the leptin-melanocortin pathway (CPE, MC3R, MC4R, MRAP2, NCOA1, PCSK1, POMC, SH2B1, and SIM1) and two glutamate receptor genes (GRM7 and GRIK1) were studied; 55 harboring heterozygous rare sequence variants and 55 with no variants. Anthropometric and routine clinical laboratory data were collected, and serum samples processed for untargeted metabolomic analysis using GC-q-MS and CE-TOF-MS and reversed-phase U(H)PLC-QTOF-MS/MS in positive and negative ionization modes. Following signal processing and multialignment, multivariate and univariate statistical analyses were applied to evaluate the genetic trait association with metabolomics data and clinical and routine laboratory features. Neither the presence of a heterozygous rare sequence variant nor clinical/routine laboratory features determined subgroups in the metabolomics data. To identify metabolomic subtypes, we applied Factor Analysis, by constructing a composite matrix from the five analytical platforms. Six factors were discovered and three different metabotypes. Subtle but neat differences in the circulating lipids, as well as in insulin sensitivity could be established, which opens the possibility to personalize the treatment according to the patients categorization into such obesity subtypes. Metabotyping in clinical contexts poses challenges due to the influence of various uncontrolled variables on metabolic phenotypes. However, this strategy reveals the potential to identify subsets of patients with similar clinical diagnoses but different metabolic conditions. This approach underscores the broader applicability of Factor Analysis in metabotyping across diverse clinical scenarios.","INSTITUTE":"CEU San Pablo University","LABORATORY":"CEMBIO","LAST_NAME":"Chamoso-Sánchez","FIRST_NAME":"David","ADDRESS":"Urb. Montepríncipe. 28925 Alcorcón, Madrid (España)","EMAIL":"david.chamososanchez@usp.ceu.es","PHONE":"(+34)913724769"},

"STUDY":{"STUDY_TITLE":"Identifying subgroups of childhood obesity by using multiplatform metabotyping","STUDY_SUMMARY":"Obesity results from an interplay between genetic predisposition and environmental factors such as diet, physical activity, culture, and socioeconomic status. Personalized treatments for obesity would be optimal, thus necessitating the identification of individual characteristics to improve the effectiveness of therapies. For example, genetic impairment of the leptin-melanocortin pathway can result in rare cases of severe early-onset obesity. Metabolomics has the potential to distinguish between a healthy and obese status; however, differentiating subsets of individuals within the obesity spectrum remains challenging. Factor analysis can integrate patient features from diverse sources, allowing an accurate subclassification of individuals. This study presents a workflow to identify metabotypes, particularly when routine clinical studies fail in patient categorization. 110 children with obesity (BMI > +2 SDS) genotyped for nine genes involved in the leptin-melanocortin pathway (CPE, MC3R, MC4R, MRAP2, NCOA1, PCSK1, POMC, SH2B1, and SIM1) and two glutamate receptor genes (GRM7 and GRIK1) were studied; 55 harboring heterozygous rare sequence variants and 55 with no variants. Anthropometric and routine clinical laboratory data were collected, and serum samples processed for untargeted metabolomic analysis using GC-q-MS and CE-TOF-MS and reversed-phase U(H)PLC-QTOF-MS/MS in positive and negative ionization modes. Following signal processing and multialignment, multivariate and univariate statistical analyses were applied to evaluate the genetic trait association with metabolomics data and clinical and routine laboratory features. Neither the presence of a heterozygous rare sequence variant nor clinical/routine laboratory features determined subgroups in the metabolomics data. To identify metabolomic subtypes, we applied Factor Analysis, by constructing a composite matrix from the five analytical platforms. Six factors were discovered and three different metabotypes. Subtle but neat differences in the circulating lipids, as well as in insulin sensitivity could be established, which opens the possibility to personalize the treatment according to the patients categorization into such obesity subtypes. Metabotyping in clinical contexts poses challenges due to the influence of various uncontrolled variables on metabolic phenotypes. However, this strategy reveals the potential to identify subsets of patients with similar clinical diagnoses but different metabolic conditions. This approach underscores the broader applicability of Factor Analysis in metabotyping across diverse clinical scenarios.","INSTITUTE":"CEU San Pablo University","LABORATORY":"CEMBIO","LAST_NAME":"Chamoso-Sánchez","FIRST_NAME":"David","ADDRESS":"Urb. Montepríncipe. 28925 Alcorcón, Madrid (España)","EMAIL":"david.chamososanchez@usp.ceu.es","NUM_GROUPS":"2","TOTAL_SUBJECTS":"110","NUM_MALES":"53","NUM_FEMALES":"57","PHONE":"(+34)913724769"},

"SUBJECT":{"SUBJECT_TYPE":"Human","SUBJECT_SPECIES":"Homo sapiens","TAXONOMY_ID":"9606"},
"SUBJECT_SAMPLE_FACTORS":[
{
"Subject ID":"-",
"Sample ID":"C842",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C842_LCPOS.mzXML","RAW_FILE_NAME":"C842_LCNEG.mzXML","RAW_FILE_NAME":"C842_GC.mzXML","RAW_FILE_NAME":"C842_CEPOS.mzXML","RAW_FILE_NAME":"C842_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1306",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1306_LCPOS.mzXML","RAW_FILE_NAME":"C1306_LCNEG.mzXML","RAW_FILE_NAME":"C1306_GC.mzXML","RAW_FILE_NAME":"C1306_CEPOS.mzXML","RAW_FILE_NAME":"C1306_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1317",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1317_LCPOS.mzXML","RAW_FILE_NAME":"C1317_LCNEG.mzXML","RAW_FILE_NAME":"C1317_GC.mzXML","RAW_FILE_NAME":"C1317_CEPOS.mzXML","RAW_FILE_NAME":"C1317_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1331",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1331_LCPOS.mzXML","RAW_FILE_NAME":"C1331_LCNEG.mzXML","RAW_FILE_NAME":"C1331_GC.mzXML","RAW_FILE_NAME":"C1331_CEPOS.mzXML","RAW_FILE_NAME":"C1331_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1336",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1336_LCPOS.mzXML","RAW_FILE_NAME":"C1336_LCNEG.mzXML","RAW_FILE_NAME":"C1336_GC.mzXML","RAW_FILE_NAME":"C1336_CEPOS.mzXML","RAW_FILE_NAME":"C1336_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1366",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1366_LCPOS.mzXML","RAW_FILE_NAME":"C1366_LCNEG.mzXML","RAW_FILE_NAME":"C1366_GC.mzXML","RAW_FILE_NAME":"C1366_CEPOS.mzXML","RAW_FILE_NAME":"C1366_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1453",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1453_LCPOS.mzXML","RAW_FILE_NAME":"C1453_LCNEG.mzXML","RAW_FILE_NAME":"C1453_GC.mzXML","RAW_FILE_NAME":"C1453_CEPOS.mzXML","RAW_FILE_NAME":"C1453_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1520",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1520_LCPOS.mzXML","RAW_FILE_NAME":"C1520_LCNEG.mzXML","RAW_FILE_NAME":"-","RAW_FILE_NAME":"C1520_CEPOS.mzXML","RAW_FILE_NAME":"C1520_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1538",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1538_LCPOS.mzXML","RAW_FILE_NAME":"C1538_LCNEG.mzXML","RAW_FILE_NAME":"C1538_GC.mzXML","RAW_FILE_NAME":"C1538_CEPOS.mzXML","RAW_FILE_NAME":"C1538_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1539",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1539_LCPOS.mzXML","RAW_FILE_NAME":"C1539_LCNEG.mzXML","RAW_FILE_NAME":"C1539_GC.mzXML","RAW_FILE_NAME":"C1539_CEPOS.mzXML","RAW_FILE_NAME":"C1539_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1548",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1548_LCPOS.mzXML","RAW_FILE_NAME":"C1548_LCNEG.mzXML","RAW_FILE_NAME":"C1548_GC.mzXML","RAW_FILE_NAME":"C1548_CEPOS.mzXML","RAW_FILE_NAME":"C1548_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1030",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1030_LCPOS.mzXML","RAW_FILE_NAME":"C1030_LCNEG.mzXML","RAW_FILE_NAME":"C1030_GC.mzXML","RAW_FILE_NAME":"C1030_CEPOS.mzXML","RAW_FILE_NAME":"C1030_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1556",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1556_LCPOS.mzXML","RAW_FILE_NAME":"C1556_LCNEG.mzXML","RAW_FILE_NAME":"C1556_GC.mzXML","RAW_FILE_NAME":"C1556_CEPOS.mzXML","RAW_FILE_NAME":"C1556_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1564",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1564_LCPOS.mzXML","RAW_FILE_NAME":"C1564_LCNEG.mzXML","RAW_FILE_NAME":"C1564_GC.mzXML","RAW_FILE_NAME":"C1564_CEPOS.mzXML","RAW_FILE_NAME":"C1564_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1768",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1768_LCPOS.mzXML","RAW_FILE_NAME":"C1768_LCNEG.mzXML","RAW_FILE_NAME":"C1768_GC.mzXML","RAW_FILE_NAME":"C1768_CEPOS.mzXML","RAW_FILE_NAME":"C1768_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1782",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1782_LCPOS.mzXML","RAW_FILE_NAME":"C1782_LCNEG.mzXML","RAW_FILE_NAME":"C1782_GC.mzXML","RAW_FILE_NAME":"C1782_CEPOS.mzXML","RAW_FILE_NAME":"C1782_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1937",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1937_LCPOS.mzXML","RAW_FILE_NAME":"C1937_LCNEG.mzXML","RAW_FILE_NAME":"C1937_GC.mzXML","RAW_FILE_NAME":"C1937_CEPOS.mzXML","RAW_FILE_NAME":"C1937_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2002",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2002_LCPOS.mzXML","RAW_FILE_NAME":"C2002_LCNEG.mzXML","RAW_FILE_NAME":"C2002_GC.mzXML","RAW_FILE_NAME":"C2002_CEPOS.mzXML","RAW_FILE_NAME":"C2002_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2158",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2158_LCPOS.mzXML","RAW_FILE_NAME":"C2158_LCNEG.mzXML","RAW_FILE_NAME":"C2158_GC.mzXML","RAW_FILE_NAME":"C2158_CEPOS.mzXML","RAW_FILE_NAME":"C2158_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2188",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2188_LCPOS.mzXML","RAW_FILE_NAME":"C2188_LCNEG.mzXML","RAW_FILE_NAME":"C2188_GC.mzXML","RAW_FILE_NAME":"C2188_CEPOS.mzXML","RAW_FILE_NAME":"C2188_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2218",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2218_LCPOS.mzXML","RAW_FILE_NAME":"C2218_LCNEG.mzXML","RAW_FILE_NAME":"C2218_GC.mzXML","RAW_FILE_NAME":"C2218_CEPOS.mzXML","RAW_FILE_NAME":"C2218_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2226",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2226_LCPOS.mzXML","RAW_FILE_NAME":"C2226_LCNEG.mzXML","RAW_FILE_NAME":"C2226_GC.mzXML","RAW_FILE_NAME":"C2226_CEPOS.mzXML","RAW_FILE_NAME":"C2226_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1131",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1131_LCPOS.mzXML","RAW_FILE_NAME":"C1131_LCNEG.mzXML","RAW_FILE_NAME":"C1131_GC.mzXML","RAW_FILE_NAME":"C1131_CEPOS.mzXML","RAW_FILE_NAME":"C1131_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2249",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2249_LCPOS.mzXML","RAW_FILE_NAME":"C2249_LCNEG.mzXML","RAW_FILE_NAME":"C2249_GC.mzXML","RAW_FILE_NAME":"C2249_CEPOS.mzXML","RAW_FILE_NAME":"C2249_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2259",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2259_LCPOS.mzXML","RAW_FILE_NAME":"C2259_LCNEG.mzXML","RAW_FILE_NAME":"C2259_GC.mzXML","RAW_FILE_NAME":"C2259_CEPOS.mzXML","RAW_FILE_NAME":"C2259_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2275",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2275_LCPOS.mzXML","RAW_FILE_NAME":"C2275_LCNEG.mzXML","RAW_FILE_NAME":"C2275_GC.mzXML","RAW_FILE_NAME":"C2275_CEPOS.mzXML","RAW_FILE_NAME":"C2275_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2284",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2284_LCPOS.mzXML","RAW_FILE_NAME":"C2284_LCNEG.mzXML","RAW_FILE_NAME":"C2284_GC.mzXML","RAW_FILE_NAME":"C2284_CEPOS.mzXML","RAW_FILE_NAME":"C2284_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2289",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2289_LCPOS.mzXML","RAW_FILE_NAME":"C2289_LCNEG.mzXML","RAW_FILE_NAME":"C2289_GC.mzXML","RAW_FILE_NAME":"C2289_CEPOS.mzXML","RAW_FILE_NAME":"C2289_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2296",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2296_LCPOS.mzXML","RAW_FILE_NAME":"C2296_LCNEG.mzXML","RAW_FILE_NAME":"C2296_GC.mzXML","RAW_FILE_NAME":"C2296_CEPOS.mzXML","RAW_FILE_NAME":"C2296_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2310",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2310_LCPOS.mzXML","RAW_FILE_NAME":"C2310_LCNEG.mzXML","RAW_FILE_NAME":"C2310_GC.mzXML","RAW_FILE_NAME":"C2310_CEPOS.mzXML","RAW_FILE_NAME":"C2310_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2312",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2312_LCPOS.mzXML","RAW_FILE_NAME":"C2312_LCNEG.mzXML","RAW_FILE_NAME":"C2312_GC.mzXML","RAW_FILE_NAME":"C2312_CEPOS.mzXML","RAW_FILE_NAME":"C2312_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2318",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2318_LCPOS.mzXML","RAW_FILE_NAME":"C2318_LCNEG.mzXML","RAW_FILE_NAME":"C2318_GC.mzXML","RAW_FILE_NAME":"C2318_CEPOS.mzXML","RAW_FILE_NAME":"C2318_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C2319",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C2319_LCPOS.mzXML","RAW_FILE_NAME":"C2319_LCNEG.mzXML","RAW_FILE_NAME":"C2319_GC.mzXML","RAW_FILE_NAME":"C2319_CEPOS.mzXML","RAW_FILE_NAME":"C2319_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1133",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1133_LCPOS.mzXML","RAW_FILE_NAME":"C1133_LCNEG.mzXML","RAW_FILE_NAME":"C1133_GC.mzXML","RAW_FILE_NAME":"C1133_CEPOS.mzXML","RAW_FILE_NAME":"C1133_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C572",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C572_LCPOS.mzXML","RAW_FILE_NAME":"C572_LCNEG.mzXML","RAW_FILE_NAME":"C572_GC.mzXML","RAW_FILE_NAME":"C572_CEPOS.mzXML","RAW_FILE_NAME":"C572_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C578",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C578_LCPOS.mzXML","RAW_FILE_NAME":"C578_LCNEG.mzXML","RAW_FILE_NAME":"C578_GC.mzXML","RAW_FILE_NAME":"C578_CEPOS.mzXML","RAW_FILE_NAME":"C578_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C615",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C615_LCPOS.mzXML","RAW_FILE_NAME":"C615_LCNEG.mzXML","RAW_FILE_NAME":"C615_GC.mzXML","RAW_FILE_NAME":"C615_CEPOS.mzXML","RAW_FILE_NAME":"C615_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C624",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C624_LCPOS.mzXML","RAW_FILE_NAME":"C624_LCNEG.mzXML","RAW_FILE_NAME":"C624_GC.mzXML","RAW_FILE_NAME":"C624_CEPOS.mzXML","RAW_FILE_NAME":"C624_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C628",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C628_LCPOS.mzXML","RAW_FILE_NAME":"C628_LCNEG.mzXML","RAW_FILE_NAME":"C628_GC.mzXML","RAW_FILE_NAME":"C628_CEPOS.mzXML","RAW_FILE_NAME":"C628_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C636",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C636_LCPOS.mzXML","RAW_FILE_NAME":"C636_LCNEG.mzXML","RAW_FILE_NAME":"C636_GC.mzXML","RAW_FILE_NAME":"C636_CEPOS.mzXML","RAW_FILE_NAME":"C636_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C668",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C668_LCPOS.mzXML","RAW_FILE_NAME":"C668_LCNEG.mzXML","RAW_FILE_NAME":"C668_GC.mzXML","RAW_FILE_NAME":"C668_CEPOS.mzXML","RAW_FILE_NAME":"C668_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C726",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C726_LCPOS.mzXML","RAW_FILE_NAME":"C726_LCNEG.mzXML","RAW_FILE_NAME":"C726_GC.mzXML","RAW_FILE_NAME":"C726_CEPOS.mzXML","RAW_FILE_NAME":"C726_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C756",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C756_LCPOS.mzXML","RAW_FILE_NAME":"C756_LCNEG.mzXML","RAW_FILE_NAME":"C756_GC.mzXML","RAW_FILE_NAME":"C756_CEPOS.mzXML","RAW_FILE_NAME":"C756_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C772",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C772_LCPOS.mzXML","RAW_FILE_NAME":"C772_LCNEG.mzXML","RAW_FILE_NAME":"C772_GC.mzXML","RAW_FILE_NAME":"C772_CEPOS.mzXML","RAW_FILE_NAME":"C772_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1171",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1171_LCPOS.mzXML","RAW_FILE_NAME":"C1171_LCNEG.mzXML","RAW_FILE_NAME":"C1171_GC.mzXML","RAW_FILE_NAME":"C1171_CEPOS.mzXML","RAW_FILE_NAME":"C1171_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C791",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C791_LCPOS.mzXML","RAW_FILE_NAME":"C791_LCNEG.mzXML","RAW_FILE_NAME":"C791_GC.mzXML","RAW_FILE_NAME":"C791_CEPOS.mzXML","RAW_FILE_NAME":"C791_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C820",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C820_LCPOS.mzXML","RAW_FILE_NAME":"C820_LCNEG.mzXML","RAW_FILE_NAME":"C820_GC.mzXML","RAW_FILE_NAME":"C820_CEPOS.mzXML","RAW_FILE_NAME":"C820_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C841",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C841_LCPOS.mzXML","RAW_FILE_NAME":"C841_LCNEG.mzXML","RAW_FILE_NAME":"C841_GC.mzXML","RAW_FILE_NAME":"C841_CEPOS.mzXML","RAW_FILE_NAME":"C841_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C877",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C877_LCPOS.mzXML","RAW_FILE_NAME":"C877_LCNEG.mzXML","RAW_FILE_NAME":"C877_GC.mzXML","RAW_FILE_NAME":"C877_CEPOS.mzXML","RAW_FILE_NAME":"C877_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C904",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C904_LCPOS.mzXML","RAW_FILE_NAME":"C904_LCNEG.mzXML","RAW_FILE_NAME":"C904_GC.mzXML","RAW_FILE_NAME":"C904_CEPOS.mzXML","RAW_FILE_NAME":"C904_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C947",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C947_LCPOS.mzXML","RAW_FILE_NAME":"C947_LCNEG.mzXML","RAW_FILE_NAME":"C947_GC.mzXML","RAW_FILE_NAME":"C947_CEPOS.mzXML","RAW_FILE_NAME":"C947_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1204",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1204_LCPOS.mzXML","RAW_FILE_NAME":"C1204_LCNEG.mzXML","RAW_FILE_NAME":"C1204_GC.mzXML","RAW_FILE_NAME":"C1204_CEPOS.mzXML","RAW_FILE_NAME":"C1204_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1222",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1222_LCPOS.mzXML","RAW_FILE_NAME":"C1222_LCNEG.mzXML","RAW_FILE_NAME":"C1222_GC.mzXML","RAW_FILE_NAME":"C1222_CEPOS.mzXML","RAW_FILE_NAME":"C1222_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1229",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1229_LCPOS.mzXML","RAW_FILE_NAME":"C1229_LCNEG.mzXML","RAW_FILE_NAME":"C1229_GC.mzXML","RAW_FILE_NAME":"C1229_CEPOS.mzXML","RAW_FILE_NAME":"C1229_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"C1238",
"Factors":{"Factor":"Idiopathic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"C1238_LCPOS.mzXML","RAW_FILE_NAME":"C1238_LCNEG.mzXML","RAW_FILE_NAME":"C1238_GC.mzXML","RAW_FILE_NAME":"C1238_CEPOS.mzXML","RAW_FILE_NAME":"C1238_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M796",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M796_LCPOS.mzXML","RAW_FILE_NAME":"M796_LCNEG.mzXML","RAW_FILE_NAME":"M796_GC.mzXML","RAW_FILE_NAME":"M796_CEPOS.mzXML","RAW_FILE_NAME":"M796_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1202",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1202_LCPOS.mzXML","RAW_FILE_NAME":"M1202_LCNEG.mzXML","RAW_FILE_NAME":"M1202_GC.mzXML","RAW_FILE_NAME":"M1202_CEPOS.mzXML","RAW_FILE_NAME":"M1202_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1223",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1223_LCPOS.mzXML","RAW_FILE_NAME":"M1223_LCNEG.mzXML","RAW_FILE_NAME":"M1223_GC.mzXML","RAW_FILE_NAME":"M1223_CEPOS.mzXML","RAW_FILE_NAME":"M1223_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1239",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1239_LCPOS.mzXML","RAW_FILE_NAME":"M1239_LCNEG.mzXML","RAW_FILE_NAME":"M1239_GC.mzXML","RAW_FILE_NAME":"M1239_CEPOS.mzXML","RAW_FILE_NAME":"M1239_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1272",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1272_LCPOS.mzXML","RAW_FILE_NAME":"M1272_LCNEG.mzXML","RAW_FILE_NAME":"M1272_GC.mzXML","RAW_FILE_NAME":"M1272_CEPOS.mzXML","RAW_FILE_NAME":"M1272_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1294",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1294_LCPOS.mzXML","RAW_FILE_NAME":"M1294_LCNEG.mzXML","RAW_FILE_NAME":"M1294_GC.mzXML","RAW_FILE_NAME":"M1294_CEPOS.mzXML","RAW_FILE_NAME":"M1294_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1309",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1309_LCPOS.mzXML","RAW_FILE_NAME":"M1309_LCNEG.mzXML","RAW_FILE_NAME":"M1309_GC.mzXML","RAW_FILE_NAME":"M1309_CEPOS.mzXML","RAW_FILE_NAME":"M1309_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1322",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1322_LCPOS.mzXML","RAW_FILE_NAME":"M1322_LCNEG.mzXML","RAW_FILE_NAME":"M1322_GC.mzXML","RAW_FILE_NAME":"M1322_CEPOS.mzXML","RAW_FILE_NAME":"M1322_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1344",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1344_LCPOS.mzXML","RAW_FILE_NAME":"M1344_LCNEG.mzXML","RAW_FILE_NAME":"M1344_GC.mzXML","RAW_FILE_NAME":"M1344_CEPOS.mzXML","RAW_FILE_NAME":"M1344_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1361",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1361_LCPOS.mzXML","RAW_FILE_NAME":"M1361_LCNEG.mzXML","RAW_FILE_NAME":"M1361_GC.mzXML","RAW_FILE_NAME":"M1361_CEPOS.mzXML","RAW_FILE_NAME":"M1361_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1380",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1380_LCPOS.mzXML","RAW_FILE_NAME":"M1380_LCNEG.mzXML","RAW_FILE_NAME":"M1380_GC.mzXML","RAW_FILE_NAME":"M1380_CEPOS.mzXML","RAW_FILE_NAME":"M1380_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1044",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1044_LCPOS.mzXML","RAW_FILE_NAME":"M1044_LCNEG.mzXML","RAW_FILE_NAME":"M1044_GC.mzXML","RAW_FILE_NAME":"M1044_CEPOS.mzXML","RAW_FILE_NAME":"M1044_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1518",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1518_LCPOS.mzXML","RAW_FILE_NAME":"M1518_LCNEG.mzXML","RAW_FILE_NAME":"M1518_GC.mzXML","RAW_FILE_NAME":"M1518_CEPOS.mzXML","RAW_FILE_NAME":"M1518_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1558",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1558_LCPOS.mzXML","RAW_FILE_NAME":"M1558_LCNEG.mzXML","RAW_FILE_NAME":"M1558_GC.mzXML","RAW_FILE_NAME":"M1558_CEPOS.mzXML","RAW_FILE_NAME":"M1558_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1605",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1605_LCPOS.mzXML","RAW_FILE_NAME":"M1605_LCNEG.mzXML","RAW_FILE_NAME":"M1605_GC.mzXML","RAW_FILE_NAME":"M1605_CEPOS.mzXML","RAW_FILE_NAME":"M1605_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1680",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1680_LCPOS.mzXML","RAW_FILE_NAME":"M1680_LCNEG.mzXML","RAW_FILE_NAME":"M1680_GC.mzXML","RAW_FILE_NAME":"M1680_CEPOS.mzXML","RAW_FILE_NAME":"M1680_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1682",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1682_LCPOS.mzXML","RAW_FILE_NAME":"M1682_LCNEG.mzXML","RAW_FILE_NAME":"M1682_GC.mzXML","RAW_FILE_NAME":"M1682_CEPOS.mzXML","RAW_FILE_NAME":"M1682_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1689",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1689_LCPOS.mzXML","RAW_FILE_NAME":"M1689_LCNEG.mzXML","RAW_FILE_NAME":"M1689_GC.mzXML","RAW_FILE_NAME":"M1689_CEPOS.mzXML","RAW_FILE_NAME":"M1689_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1787",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1787_LCPOS.mzXML","RAW_FILE_NAME":"M1787_LCNEG.mzXML","RAW_FILE_NAME":"M1787_GC.mzXML","RAW_FILE_NAME":"M1787_CEPOS.mzXML","RAW_FILE_NAME":"M1787_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1794",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1794_LCPOS.mzXML","RAW_FILE_NAME":"M1794_LCNEG.mzXML","RAW_FILE_NAME":"M1794_GC.mzXML","RAW_FILE_NAME":"M1794_CEPOS.mzXML","RAW_FILE_NAME":"M1794_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1843",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1843_LCPOS.mzXML","RAW_FILE_NAME":"M1843_LCNEG.mzXML","RAW_FILE_NAME":"M1843_GC.mzXML","RAW_FILE_NAME":"M1843_CEPOS.mzXML","RAW_FILE_NAME":"M1843_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1860",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1860_LCPOS.mzXML","RAW_FILE_NAME":"M1860_LCNEG.mzXML","RAW_FILE_NAME":"M1860_GC.mzXML","RAW_FILE_NAME":"M1860_CEPOS.mzXML","RAW_FILE_NAME":"M1860_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1078",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1078_LCPOS.mzXML","RAW_FILE_NAME":"M1078_LCNEG.mzXML","RAW_FILE_NAME":"M1078_GC.mzXML","RAW_FILE_NAME":"M1078_CEPOS.mzXML","RAW_FILE_NAME":"M1078_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1884",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1884_LCPOS.mzXML","RAW_FILE_NAME":"M1884_LCNEG.mzXML","RAW_FILE_NAME":"M1884_GC.mzXML","RAW_FILE_NAME":"M1884_CEPOS.mzXML","RAW_FILE_NAME":"M1884_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1986",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1986_LCPOS.mzXML","RAW_FILE_NAME":"M1986_LCNEG.mzXML","RAW_FILE_NAME":"M1986_GC.mzXML","RAW_FILE_NAME":"M1986_CEPOS.mzXML","RAW_FILE_NAME":"M1986_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M199",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M199_LCPOS.mzXML","RAW_FILE_NAME":"M199_LCNEG.mzXML","RAW_FILE_NAME":"M199_GC.mzXML","RAW_FILE_NAME":"M199_CEPOS.mzXML","RAW_FILE_NAME":"M199_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2050",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2050_LCPOS.mzXML","RAW_FILE_NAME":"M2050_LCNEG.mzXML","RAW_FILE_NAME":"M2050_GC.mzXML","RAW_FILE_NAME":"M2050_CEPOS.mzXML","RAW_FILE_NAME":"M2050_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2058",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2058_LCPOS.mzXML","RAW_FILE_NAME":"M2058_LCNEG.mzXML","RAW_FILE_NAME":"M2058_GC.mzXML","RAW_FILE_NAME":"M2058_CEPOS.mzXML","RAW_FILE_NAME":"M2058_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2105",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2105_LCPOS.mzXML","RAW_FILE_NAME":"M2105_LCNEG.mzXML","RAW_FILE_NAME":"M2105_GC.mzXML","RAW_FILE_NAME":"M2105_CEPOS.mzXML","RAW_FILE_NAME":"M2105_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2126",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2126_LCPOS.mzXML","RAW_FILE_NAME":"M2126_LCNEG.mzXML","RAW_FILE_NAME":"M2126_GC.mzXML","RAW_FILE_NAME":"M2126_CEPOS.mzXML","RAW_FILE_NAME":"M2126_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2178",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2178_LCPOS.mzXML","RAW_FILE_NAME":"M2178_LCNEG.mzXML","RAW_FILE_NAME":"M2178_GC.mzXML","RAW_FILE_NAME":"M2178_CEPOS.mzXML","RAW_FILE_NAME":"M2178_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2195",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2195_LCPOS.mzXML","RAW_FILE_NAME":"M2195_LCNEG.mzXML","RAW_FILE_NAME":"M2195_GC.mzXML","RAW_FILE_NAME":"M2195_CEPOS.mzXML","RAW_FILE_NAME":"M2195_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2220",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2220_LCPOS.mzXML","RAW_FILE_NAME":"M2220_LCNEG.mzXML","RAW_FILE_NAME":"M2220_GC.mzXML","RAW_FILE_NAME":"M2220_CEPOS.mzXML","RAW_FILE_NAME":"M2220_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1104",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1104_LCPOS.mzXML","RAW_FILE_NAME":"M1104_LCNEG.mzXML","RAW_FILE_NAME":"M1104_GC.mzXML","RAW_FILE_NAME":"M1104_CEPOS.mzXML","RAW_FILE_NAME":"M1104_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2253",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2253_LCPOS.mzXML","RAW_FILE_NAME":"M2253_LCNEG.mzXML","RAW_FILE_NAME":"M2253_GC.mzXML","RAW_FILE_NAME":"M2253_CEPOS.mzXML","RAW_FILE_NAME":"M2253_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M2258",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M2258_LCPOS.mzXML","RAW_FILE_NAME":"M2258_LCNEG.mzXML","RAW_FILE_NAME":"M2258_GC.mzXML","RAW_FILE_NAME":"M2258_CEPOS.mzXML","RAW_FILE_NAME":"M2258_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M37",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M37_LCPOS.mzXML","RAW_FILE_NAME":"M37_LCNEG.mzXML","RAW_FILE_NAME":"M37_GC.mzXML","RAW_FILE_NAME":"M37_CEPOS.mzXML","RAW_FILE_NAME":"M37_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M393",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M393_LCPOS.mzXML","RAW_FILE_NAME":"M393_LCNEG.mzXML","RAW_FILE_NAME":"M393_GC.mzXML","RAW_FILE_NAME":"M393_CEPOS.mzXML","RAW_FILE_NAME":"M393_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M489",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M489_LCPOS.mzXML","RAW_FILE_NAME":"M489_LCNEG.mzXML","RAW_FILE_NAME":"M489_GC.mzXML","RAW_FILE_NAME":"M489_CEPOS.mzXML","RAW_FILE_NAME":"M489_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M516",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M516_LCPOS.mzXML","RAW_FILE_NAME":"M516_LCNEG.mzXML","RAW_FILE_NAME":"M516_GC.mzXML","RAW_FILE_NAME":"M516_CEPOS.mzXML","RAW_FILE_NAME":"M516_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M538",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M538_LCPOS.mzXML","RAW_FILE_NAME":"M538_LCNEG.mzXML","RAW_FILE_NAME":"M538_GC.mzXML","RAW_FILE_NAME":"M538_CEPOS.mzXML","RAW_FILE_NAME":"M538_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M539",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M539_LCPOS.mzXML","RAW_FILE_NAME":"M539_LCNEG.mzXML","RAW_FILE_NAME":"M539_GC.mzXML","RAW_FILE_NAME":"M539_CEPOS.mzXML","RAW_FILE_NAME":"M539_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M637",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M637_LCPOS.mzXML","RAW_FILE_NAME":"M637_LCNEG.mzXML","RAW_FILE_NAME":"M637_GC.mzXML","RAW_FILE_NAME":"M637_CEPOS.mzXML","RAW_FILE_NAME":"M637_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M759",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M759_LCPOS.mzXML","RAW_FILE_NAME":"M759_LCNEG.mzXML","RAW_FILE_NAME":"M759_GC.mzXML","RAW_FILE_NAME":"M759_CEPOS.mzXML","RAW_FILE_NAME":"M759_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1116",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1116_LCPOS.mzXML","RAW_FILE_NAME":"M1116_LCNEG.mzXML","RAW_FILE_NAME":"M1116_GC.mzXML","RAW_FILE_NAME":"M1116_CEPOS.mzXML","RAW_FILE_NAME":"M1116_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M803",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M803_LCPOS.mzXML","RAW_FILE_NAME":"M803_LCNEG.mzXML","RAW_FILE_NAME":"M803_GC.mzXML","RAW_FILE_NAME":"M803_CEPOS.mzXML","RAW_FILE_NAME":"M803_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M881",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M881_LCPOS.mzXML","RAW_FILE_NAME":"M881_LCNEG.mzXML","RAW_FILE_NAME":"M881_GC.mzXML","RAW_FILE_NAME":"M881_CEPOS.mzXML","RAW_FILE_NAME":"M881_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M908",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M908_LCPOS.mzXML","RAW_FILE_NAME":"M908_LCNEG.mzXML","RAW_FILE_NAME":"M908_GC.mzXML","RAW_FILE_NAME":"M908_CEPOS.mzXML","RAW_FILE_NAME":"M908_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M913",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M913_LCPOS.mzXML","RAW_FILE_NAME":"M913_LCNEG.mzXML","RAW_FILE_NAME":"M913_GC.mzXML","RAW_FILE_NAME":"M913_CEPOS.mzXML","RAW_FILE_NAME":"M913_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M962",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M962_LCPOS.mzXML","RAW_FILE_NAME":"M962_LCNEG.mzXML","RAW_FILE_NAME":"M962_GC.mzXML","RAW_FILE_NAME":"M962_CEPOS.mzXML","RAW_FILE_NAME":"M962_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M996",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M996_LCPOS.mzXML","RAW_FILE_NAME":"M996_LCNEG.mzXML","RAW_FILE_NAME":"M996_GC.mzXML","RAW_FILE_NAME":"M996_CEPOS.mzXML","RAW_FILE_NAME":"M996_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1120",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1120_LCPOS.mzXML","RAW_FILE_NAME":"M1120_LCNEG.mzXML","RAW_FILE_NAME":"M1120_GC.mzXML","RAW_FILE_NAME":"M1120_CEPOS.mzXML","RAW_FILE_NAME":"M1120_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1145",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1145_LCPOS.mzXML","RAW_FILE_NAME":"M1145_LCNEG.mzXML","RAW_FILE_NAME":"M1145_GC.mzXML","RAW_FILE_NAME":"M1145_CEPOS.mzXML","RAW_FILE_NAME":"M1145_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1147",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1147_LCPOS.mzXML","RAW_FILE_NAME":"M1147_LCNEG.mzXML","RAW_FILE_NAME":"M1147_GC.mzXML","RAW_FILE_NAME":"M1147_CEPOS.mzXML","RAW_FILE_NAME":"M1147_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"M1176",
"Factors":{"Factor":"Monogenic obesity"},
"Additional sample data":{"RAW_FILE_NAME":"M1176_LCPOS.mzXML","RAW_FILE_NAME":"M1176_LCNEG.mzXML","RAW_FILE_NAME":"M1176_GC.mzXML","RAW_FILE_NAME":"M1176_CEPOS.mzXML","RAW_FILE_NAME":"M1176_CENEG.mzXML"}
},
{
"Subject ID":"-",
"Sample ID":"QC",
"Factors":{"Factor":"Quality control"},
"Additional sample data":{"RAW_FILE_NAME":"QC_LCPOS.mzXML","RAW_FILE_NAME":"QC_LCNEG.mzXML","RAW_FILE_NAME":"QC_GC.mzXML","RAW_FILE_NAME":"QC_CEPOS.mzXML","RAW_FILE_NAME":"QC_CENEG.mzXML"}
}
],
"COLLECTION":{"COLLECTION_SUMMARY":"A 12‐hour fasting serum sample (drawn, immediately processed, aliquoted and stored at −80°C until assayed) was used.","SAMPLE_TYPE":"Blood (serum)","STORAGE_CONDITIONS":"-80℃"},

"TREATMENT":{"TREATMENT_SUMMARY":"N/A"},

"SAMPLEPREP":{"SAMPLEPREP_SUMMARY":"For LC-MS analysis, 40 µL of serum was mixed with 800 µL of a cold mixture (-20ºC) of methanol:MTBE:Chloroform (1.33:1:1, v/v/v) with Sphinganine (D17:0) and palmitic acid-d31 as internal standards. Samples were vortexed for 30 s and shaken for 20 min at maximum speed at room temperature. Next, samples were centrifuged (13,200 rpm, room temperature, 5 min). After centrifugation, supernatant was directly injected into the system. For GC-MS analysis, protein precipitation was achieved by mixing 1 volume of serum with 3 volumes of cold (-20ºC) acetonitrile with 25 ppm of palmitic acid-d31 as internal standard, followed by methoximation with O-methoxyamine hydrochloride (15 mg/mL) in pyridine, and sylation with BSTFA: TMCS (99:1). Finally, 20 ppm of tricosane in heptane was added as second internal standard. For CE-MS analysis, 100 µL of serum was mixed with 100 µL of 0.2 M formic acid containing 5% acetonitrile and 0.4 mM methionine sulfone, 2 mM paracetamol and 0.5 mM 4-Morpholineethanesulfonic acid, 2-(N-Morpholino) ethanesulfonic acid (MES) as internal standards. The sample was transferred to an ultracentrifugation device (Millipore Ireland Ltd., Carrigtohill, Ireland) with a 30 kDa protein cutoff for deproteinization through centrifugation (2000 × g, 4 °C, 90 min)."},

"CHROMATOGRAPHY":{"CHROMATOGRAPHY_SUMMARY":"CE-MS NEG","CHROMATOGRAPHY_TYPE":"CE","INSTRUMENT_NAME":"Agilent 7100 CE","COLUMN_NAME":"Agilent Technologies fused polyvinyl alcohol capillary PVA (total length, 97.6 cm; internal diameter, 50 µm)","SOLVENT_A":"BGE (0.1 M formic acid solution)","SOLVENT_B":"N/A","FLOW_GRADIENT":"None","FLOW_RATE":"None","COLUMN_TEMPERATURE":"20 ºC","INTERNAL_STANDARD":"methionine sulfone, paracetamol and 4-morpholineethanesulfonic acid, 2-(N-morpholino)ethanesulfonic acid (MES)","INTERNAL_STANDARD_MT":"methionine sulfone","ANALYTICAL_TIME":"55 min","CAPILLARY_VOLTAGE":"-30 KV","SHEATH_LIQUID":"Methanol: water (1:1, v/v) and two reference masses (20 μL of purine: 121.0509 and 20 μL of HP-0922: 922.0098) at a flow rate of 0.6 mL/min (1:100 of split ratio)"},

"ANALYSIS":{"ANALYSIS_TYPE":"MS"},

"MS":{"INSTRUMENT_NAME":"Agilent 6224 TOF","INSTRUMENT_TYPE":"TOF","MS_TYPE":"EI","ION_MODE":"NEGATIVE","MS_COMMENTS":". Mass spectrometry was operated in negative polarity, with a mass range 60–1000 m/z at a rate of 1.0 spectrum /s. Other parameters for the MS were: fragmentor at 125 V, skimmer at 65 V, OctopoleRFPeak at 750 V, drying gas temperature at 275 °C, flow at 10 L/min, nebulizer at 0 psig and capillary voltage at 2000 V. The sheath liquid used consisted of methanol: water (1:1, v/v) and two reference masses (20 μL of purine: 121.0509 and 20 μL of HP-0922: 922.0098) at a flow rate of 0.6 mL/min (1:100 of split ratio). The MS data in negative ionization were acquired using the Agilent MassHunter Workstation Software LC/MS Data Acquisition for 6200 series TOF/6500 series Q-TOF B 6.01.6172 SP1 (Agilent Technologies), and the raw data were inspected with the MassHunter Qualitative software (version B.08.00, Agilent Technologies) before data processing.","MS_RESULTS_FILE":"ST002993_AN004917_Results.txt UNITS:Corrected areas Has m/z:Neutral masses Has RT:Yes RT units:Minutes"}

}