#METABOLOMICS WORKBENCH llinaslab_20160711_135207 DATATRACK_ID:677 STUDY_ID:ST000441 ANALYSIS_ID:AN000692 PROJECT_ID:PR000340 VERSION 1 CREATED_ON September 21, 2017, 12:02 pm #PROJECT PR:PROJECT_TITLE Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways PR:PROJECT_SUMMARY Here we interrogated the in vitro metabolic effects of 189 drugs (including 169 PR:PROJECT_SUMMARY of the drug-like compounds from the Malaria Box) using ultra-high performance PR:PROJECT_SUMMARY liquid chromatography mass-spectrometry (UHPLC-MS). The resulting metabolic PR:PROJECT_SUMMARY fingerprints provide information on the parasite biochemical pathways affected PR:PROJECT_SUMMARY by pharmacologic intervention and offer a critical blueprint for selecting and PR:PROJECT_SUMMARY advancing lead compounds as next-generation antimalarial drugs. Our results PR:PROJECT_SUMMARY reveal several major classes of metabolic disruption, which allow us to predict PR:PROJECT_SUMMARY the mode-of-action (MoA) for many of the Malaria Box compounds. PR:INSTITUTE Penn State University PR:LAST_NAME Llinas PR:FIRST_NAME Manuel PR:ADDRESS W126 Millenium Science Complex, University Park, PA 16802 PR:EMAIL manuel@psu.edu PR:PHONE (814) 867-3527 #STUDY ST:STUDY_TITLE Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways ST:STUDY_SUMMARY Here we interrogated the in vitro metabolic effects of 189 drugs (including 169 ST:STUDY_SUMMARY of the drug-like compounds from the Malaria Box) using ultra-high performance ST:STUDY_SUMMARY liquid chromatography mass-spectrometry (UHPLC-MS). The resulting metabolic ST:STUDY_SUMMARY fingerprints provide information on the parasite biochemical pathways affected ST:STUDY_SUMMARY by pharmacologic intervention and offer a critical blueprint for selecting and ST:STUDY_SUMMARY advancing lead compounds as next-generation antimalarial drugs. Our results ST:STUDY_SUMMARY reveal several major classes of metabolic disruption, which allow us to predict ST:STUDY_SUMMARY the mode-of-action (MoA) for many of the Malaria Box compounds. ST:INSTITUTE Penn State University ST:LAST_NAME Llinas ST:FIRST_NAME Manuel ST:ADDRESS W126 Millenium Science Complex, University Park, PA 16802 ST:EMAIL manuel@psu.edu ST:PHONE (814) 867-3527 #SUBJECT SU:SUBJECT_TYPE MACS purified infected RBCs SU:SUBJECT_SPECIES Plasmodium falciparum SU:TAXONOMY_ID 5833 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - Antimycin_A Drug:Antimycin_A SUBJECT_SAMPLE_FACTORS - Atovaquone Drug:Atovaquone SUBJECT_SAMPLE_FACTORS - AZ412 Drug:AZ412 SUBJECT_SAMPLE_FACTORS - Chloroquine Drug:Chloroquine SUBJECT_SAMPLE_FACTORS - DDD498 Drug:DDD498 SUBJECT_SAMPLE_FACTORS - Deoxyglucose Drug:Deoxyglucose SUBJECT_SAMPLE_FACTORS - DSM1 Drug:DSM1 SUBJECT_SAMPLE_FACTORS - DSM265 Drug:DSM265 SUBJECT_SAMPLE_FACTORS - ELQ-300 Drug:ELQ-300 SUBJECT_SAMPLE_FACTORS - KAF156_analogue Drug:KAF156_analogue SUBJECT_SAMPLE_FACTORS - KAF246 Drug:KAF246 SUBJECT_SAMPLE_FACTORS - MMV000248 Drug:MMV000248 SUBJECT_SAMPLE_FACTORS - MMV000356 Drug:MMV000356 SUBJECT_SAMPLE_FACTORS - MMV000483 Drug:MMV000483 SUBJECT_SAMPLE_FACTORS - MMV000498 Drug:MMV000498 SUBJECT_SAMPLE_FACTORS - MMV000561 Drug:MMV000561 SUBJECT_SAMPLE_FACTORS - MMV000563 Drug:MMV000563 SUBJECT_SAMPLE_FACTORS - MMV000620 Drug:MMV000620 SUBJECT_SAMPLE_FACTORS - MMV000634 Drug:MMV000634 SUBJECT_SAMPLE_FACTORS - MMV000653 Drug:MMV000653 SUBJECT_SAMPLE_FACTORS - MMV000662 Drug:MMV000662 SUBJECT_SAMPLE_FACTORS - MMV000760 Drug:MMV000760 SUBJECT_SAMPLE_FACTORS - MMV000788 Drug:MMV000788 SUBJECT_SAMPLE_FACTORS - MMV000848 Drug:MMV000848 SUBJECT_SAMPLE_FACTORS - MMV000963 Drug:MMV000963 SUBJECT_SAMPLE_FACTORS - MMV000972 Drug:MMV000972 SUBJECT_SAMPLE_FACTORS - MMV001038 Drug:MMV001038 SUBJECT_SAMPLE_FACTORS - MMV001049 Drug:MMV001049 SUBJECT_SAMPLE_FACTORS - MMV001230 Drug:MMV001230 SUBJECT_SAMPLE_FACTORS - MMV001246 Drug:MMV001246 SUBJECT_SAMPLE_FACTORS - MMV001255 Drug:MMV001255 SUBJECT_SAMPLE_FACTORS - MMV001344 Drug:MMV001344 SUBJECT_SAMPLE_FACTORS - MMV006087 Drug:MMV006087 SUBJECT_SAMPLE_FACTORS - MMV006188 Drug:MMV006188 SUBJECT_SAMPLE_FACTORS - MMV006278 Drug:MMV006278 SUBJECT_SAMPLE_FACTORS - MMV006319 Drug:MMV006319 SUBJECT_SAMPLE_FACTORS - MMV006427 Drug:MMV006427 SUBJECT_SAMPLE_FACTORS - MMV006429 Drug:MMV006429 SUBJECT_SAMPLE_FACTORS - MMV006455 Drug:MMV006455 SUBJECT_SAMPLE_FACTORS - MMV006545 Drug:MMV006545 SUBJECT_SAMPLE_FACTORS - MMV006587 Drug:MMV006587 SUBJECT_SAMPLE_FACTORS - MMV006704 Drug:MMV006704 SUBJECT_SAMPLE_FACTORS - MMV006706 Drug:MMV006706 SUBJECT_SAMPLE_FACTORS - MMV006767 Drug:MMV006767 SUBJECT_SAMPLE_FACTORS - MMV006820 Drug:MMV006820 SUBJECT_SAMPLE_FACTORS - MMV006913 Drug:MMV006913 SUBJECT_SAMPLE_FACTORS - MMV006937 Drug:MMV006937 SUBJECT_SAMPLE_FACTORS - MMV007116 Drug:MMV007116 SUBJECT_SAMPLE_FACTORS - MMV007430 Drug:MMV007430 SUBJECT_SAMPLE_FACTORS - MMV007564 Drug:MMV007564 SUBJECT_SAMPLE_FACTORS - MMV007571 Drug:MMV007571 SUBJECT_SAMPLE_FACTORS - MMV007617 Drug:MMV007617 SUBJECT_SAMPLE_FACTORS - MMV007808 Drug:MMV007808 SUBJECT_SAMPLE_FACTORS - MMV007839 Drug:MMV007839 SUBJECT_SAMPLE_FACTORS - MMV007875 Drug:MMV007875 SUBJECT_SAMPLE_FACTORS - MMV007881 Drug:MMV007881 SUBJECT_SAMPLE_FACTORS - MMV007906 Drug:MMV007906 SUBJECT_SAMPLE_FACTORS - MMV007907 Drug:MMV007907 SUBJECT_SAMPLE_FACTORS - MMV007977 Drug:MMV007977 SUBJECT_SAMPLE_FACTORS - MMV007978 Drug:MMV007978 SUBJECT_SAMPLE_FACTORS - MMV008127 Drug:MMV008127 SUBJECT_SAMPLE_FACTORS - MMV008138 Drug:MMV008138 SUBJECT_SAMPLE_FACTORS - MMV008149 Drug:MMV008149 SUBJECT_SAMPLE_FACTORS - MMV008212 Drug:MMV008212 SUBJECT_SAMPLE_FACTORS - MMV008270 Drug:MMV008270 SUBJECT_SAMPLE_FACTORS - MMV008956 Drug:MMV008956 SUBJECT_SAMPLE_FACTORS - MMV009063 Drug:MMV009063 SUBJECT_SAMPLE_FACTORS - MMV009108 Drug:MMV009108 SUBJECT_SAMPLE_FACTORS - MMV011099 Drug:MMV011099 SUBJECT_SAMPLE_FACTORS - MMV011256 Drug:MMV011256 SUBJECT_SAMPLE_FACTORS - MMV011259 Drug:MMV011259 SUBJECT_SAMPLE_FACTORS - MMV011567 Drug:MMV011567 SUBJECT_SAMPLE_FACTORS - MMV011576 Drug:MMV011576 SUBJECT_SAMPLE_FACTORS - MMV011795 Drug:MMV011795 SUBJECT_SAMPLE_FACTORS - MMV011944 Drug:MMV011944 SUBJECT_SAMPLE_FACTORS - MMV018984 Drug:MMV018984 SUBJECT_SAMPLE_FACTORS - MMV019017 Drug:MMV019017 SUBJECT_SAMPLE_FACTORS - MMV019064 Drug:MMV019064 SUBJECT_SAMPLE_FACTORS - MMV019066 Drug:MMV019066 SUBJECT_SAMPLE_FACTORS - MMV019074 Drug:MMV019074 SUBJECT_SAMPLE_FACTORS - MMV019110 Drug:MMV019110 SUBJECT_SAMPLE_FACTORS - MMV019124 Drug:MMV019124 SUBJECT_SAMPLE_FACTORS - MMV019127 Drug:MMV019127 SUBJECT_SAMPLE_FACTORS - MMV019202 Drug:MMV019202 SUBJECT_SAMPLE_FACTORS - MMV019258 Drug:MMV019258 SUBJECT_SAMPLE_FACTORS - MMV019266 Drug:MMV019266 SUBJECT_SAMPLE_FACTORS - MMV019313 Drug:MMV019313 SUBJECT_SAMPLE_FACTORS - MMV019662 Drug:MMV019662 SUBJECT_SAMPLE_FACTORS - MMV019670 Drug:MMV019670 SUBJECT_SAMPLE_FACTORS - MMV019700 Drug:MMV019700 SUBJECT_SAMPLE_FACTORS - MMV019738 Drug:MMV019738 SUBJECT_SAMPLE_FACTORS - MMV019758 Drug:MMV019758 SUBJECT_SAMPLE_FACTORS - MMV019780 Drug:MMV019780 SUBJECT_SAMPLE_FACTORS - MMV019871 Drug:MMV019871 SUBJECT_SAMPLE_FACTORS - MMV020275 Drug:MMV020275 SUBJECT_SAMPLE_FACTORS - MMV020439 Drug:MMV020439 SUBJECT_SAMPLE_FACTORS - MMV020490 Drug:MMV020490 SUBJECT_SAMPLE_FACTORS - MMV020492 Drug:MMV020492 SUBJECT_SAMPLE_FACTORS - MMV020500 Drug:MMV020500 SUBJECT_SAMPLE_FACTORS - MMV020505 Drug:MMV020505 SUBJECT_SAMPLE_FACTORS - MMV020548 Drug:MMV020548 SUBJECT_SAMPLE_FACTORS - MMV020549 Drug:MMV020549 SUBJECT_SAMPLE_FACTORS - MMV020651 Drug:MMV020651 SUBJECT_SAMPLE_FACTORS - MMV020654 Drug:MMV020654 SUBJECT_SAMPLE_FACTORS - MMV020660 Drug:MMV020660 SUBJECT_SAMPLE_FACTORS - MMV020700 Drug:MMV020700 SUBJECT_SAMPLE_FACTORS - MMV056726 Drug:MMV056726 SUBJECT_SAMPLE_FACTORS - MMV075490 Drug:MMV075490 SUBJECT_SAMPLE_FACTORS - MMV084940 Drug:MMV084940 SUBJECT_SAMPLE_FACTORS - MMV142383 Drug:MMV142383 SUBJECT_SAMPLE_FACTORS - MMV274073 Drug:MMV274073 SUBJECT_SAMPLE_FACTORS - MMV306025 Drug:MMV306025 SUBJECT_SAMPLE_FACTORS - MMV390048 Drug:MMV390048 SUBJECT_SAMPLE_FACTORS - MMV396632 Drug:MMV396632 SUBJECT_SAMPLE_FACTORS - MMV396633 Drug:MMV396633 SUBJECT_SAMPLE_FACTORS - MMV396669 Drug:MMV396669 SUBJECT_SAMPLE_FACTORS - MMV396672 Drug:MMV396672 SUBJECT_SAMPLE_FACTORS - MMV396681 Drug:MMV396681 SUBJECT_SAMPLE_FACTORS - MMV396703 Drug:MMV396703 SUBJECT_SAMPLE_FACTORS - MMV396705 Drug:MMV396705 SUBJECT_SAMPLE_FACTORS - MMV396715 Drug:MMV396715 SUBJECT_SAMPLE_FACTORS - MMV396719 Drug:MMV396719 SUBJECT_SAMPLE_FACTORS - MMV396736 Drug:MMV396736 SUBJECT_SAMPLE_FACTORS - MMV396744 Drug:MMV396744 SUBJECT_SAMPLE_FACTORS - MMV396749 Drug:MMV396749 SUBJECT_SAMPLE_FACTORS - MMV396794 Drug:MMV396794 SUBJECT_SAMPLE_FACTORS - MMV396797 Drug:MMV396797 SUBJECT_SAMPLE_FACTORS - MMV403679 Drug:MMV403679 SUBJECT_SAMPLE_FACTORS - MMV665782 Drug:MMV665782 SUBJECT_SAMPLE_FACTORS - MMV665789 Drug:MMV665789 SUBJECT_SAMPLE_FACTORS - MMV665796 Drug:MMV665796 SUBJECT_SAMPLE_FACTORS - MMV665798 Drug:MMV665798 SUBJECT_SAMPLE_FACTORS - MMV665799 Drug:MMV665799 SUBJECT_SAMPLE_FACTORS - MMV665800 Drug:MMV665800 SUBJECT_SAMPLE_FACTORS - MMV665803 Drug:MMV665803 SUBJECT_SAMPLE_FACTORS - MMV665806 Drug:MMV665806 SUBJECT_SAMPLE_FACTORS - MMV665817 Drug:MMV665817 SUBJECT_SAMPLE_FACTORS - MMV665826 Drug:MMV665826 SUBJECT_SAMPLE_FACTORS - MMV665850 Drug:MMV665850 SUBJECT_SAMPLE_FACTORS - MMV665857 Drug:MMV665857 SUBJECT_SAMPLE_FACTORS - MMV665874 Drug:MMV665874 SUBJECT_SAMPLE_FACTORS - MMV665876 Drug:MMV665876 SUBJECT_SAMPLE_FACTORS - MMV665878 Drug:MMV665878 SUBJECT_SAMPLE_FACTORS - MMV665879 Drug:MMV665879 SUBJECT_SAMPLE_FACTORS - MMV665883 Drug:MMV665883 SUBJECT_SAMPLE_FACTORS - MMV665890 Drug:MMV665890 SUBJECT_SAMPLE_FACTORS - MMV665897 Drug:MMV665897 SUBJECT_SAMPLE_FACTORS - MMV665899 Drug:MMV665899 SUBJECT_SAMPLE_FACTORS - MMV665901 Drug:MMV665901 SUBJECT_SAMPLE_FACTORS - MMV665902 Drug:MMV665902 SUBJECT_SAMPLE_FACTORS - MMV665904 Drug:MMV665904 SUBJECT_SAMPLE_FACTORS - MMV665906 Drug:MMV665906 SUBJECT_SAMPLE_FACTORS - MMV665915 Drug:MMV665915 SUBJECT_SAMPLE_FACTORS - MMV665916 Drug:MMV665916 SUBJECT_SAMPLE_FACTORS - MMV665918 Drug:MMV665918 SUBJECT_SAMPLE_FACTORS - MMV665928 Drug:MMV665928 SUBJECT_SAMPLE_FACTORS - MMV665929 Drug:MMV665929 SUBJECT_SAMPLE_FACTORS - MMV665935 Drug:MMV665935 SUBJECT_SAMPLE_FACTORS - MMV665939 Drug:MMV665939 SUBJECT_SAMPLE_FACTORS - MMV665940 Drug:MMV665940 SUBJECT_SAMPLE_FACTORS - MMV665946 Drug:MMV665946 SUBJECT_SAMPLE_FACTORS - MMV665948 Drug:MMV665948 SUBJECT_SAMPLE_FACTORS - MMV665954 Drug:MMV665954 SUBJECT_SAMPLE_FACTORS - MMV665979 Drug:MMV665979 SUBJECT_SAMPLE_FACTORS - MMV666009 Drug:MMV666009 SUBJECT_SAMPLE_FACTORS - MMV666057 Drug:MMV666057 SUBJECT_SAMPLE_FACTORS - MMV666061 Drug:MMV666061 SUBJECT_SAMPLE_FACTORS - MMV666067 Drug:MMV666067 SUBJECT_SAMPLE_FACTORS - MMV666069 Drug:MMV666069 SUBJECT_SAMPLE_FACTORS - MMV666070 Drug:MMV666070 SUBJECT_SAMPLE_FACTORS - MMV666071 Drug:MMV666071 SUBJECT_SAMPLE_FACTORS - MMV666072 Drug:MMV666072 SUBJECT_SAMPLE_FACTORS - MMV666080 Drug:MMV666080 SUBJECT_SAMPLE_FACTORS - MMV666081 Drug:MMV666081 SUBJECT_SAMPLE_FACTORS - MMV666102 Drug:MMV666102 SUBJECT_SAMPLE_FACTORS - MMV666103 Drug:MMV666103 SUBJECT_SAMPLE_FACTORS - MMV666105 Drug:MMV666105 SUBJECT_SAMPLE_FACTORS - MMV666110 Drug:MMV666110 SUBJECT_SAMPLE_FACTORS - MMV666116 Drug:MMV666116 SUBJECT_SAMPLE_FACTORS - MMV666693 Drug:MMV666693 SUBJECT_SAMPLE_FACTORS - MMV667487 Drug:MMV667487 SUBJECT_SAMPLE_FACTORS - Myxothiazol Drug:Myxothiazol SUBJECT_SAMPLE_FACTORS - NITD609 Drug:NITD609 SUBJECT_SAMPLE_FACTORS - OZ277 Drug:OZ277 SUBJECT_SAMPLE_FACTORS - OZ439 Drug:OZ439 SUBJECT_SAMPLE_FACTORS - P218 Drug:P218 SUBJECT_SAMPLE_FACTORS - Pyrimethamine Drug:Pyrimethamine SUBJECT_SAMPLE_FACTORS - SJ733 Drug:SJ733 SUBJECT_SAMPLE_FACTORS - WR Drug:WR SUBJECT_SAMPLE_FACTORS - WR99210 Drug:WR99210 #COLLECTION CO:COLLECTION_SUMMARY Cells were pelleted and the media aspirated prior to methanol extraction #TREATMENT TR:TREATMENT_SUMMARY Magnetically purified iRBCs (~20uL) were treated with >2XIC50 drug for 2.5 hours #SAMPLEPREP SP:SAMPLEPREP_SUMMARY 90% Methanol/10% water at 50:1 solvent/cell pellet followed by vortexing and SP:SAMPLEPREP_SUMMARY clarification via centrifugation SP:PROCESSING_METHOD Lysis SP:PROCESSING_STORAGE_CONDITIONS 4 C SP:EXTRACT_CLEANUP Clarification via centrifugation followed by nitrogen drying SP:EXTRACT_STORAGE -80 C SP:SAMPLE_RESUSPENSION 6X pellet volume of HPLC H2O SP:SAMPLE_SPIKING Internal Standard 13C4, 15N1-Aspartate used for sample preparation normalizer #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY See Wenyun Lu et al Anal. Chem. 2010 or SA Cobbold et al JBC 2013 for detailed CH:CHROMATOGRAPHY_SUMMARY chromatography description CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Exactive Orbitrap Plus CH:COLUMN_NAME Phenomenex Synergi Hydro RP (100 x 2mm, 2.5um) CH:INTERNAL_STANDARD 13C4, 15N1-Aspartate CH:PRECONDITIONING Water Blanks #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:FRAGMENTATION_METHOD None MS:MASS_ACCURACY <1 ppm #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS log2 fold change vs untreated MS_METABOLITE_DATA_START Samples Antimycin_A Atovaquone AZ412 Chloroquine DDD498 Deoxyglucose DSM1 DSM265 ELQ-300 KAF156_analogue KAF246 MMV000248 MMV000356 MMV000483 MMV000498 MMV000561 MMV000563 MMV000620 MMV000634 MMV000653 MMV000662 MMV000760 MMV000788 MMV000848 MMV000963 MMV000972 MMV001038 MMV001049 MMV001230 MMV001246 MMV001255 MMV001344 MMV006087 MMV006188 MMV006278 MMV006319 MMV006427 MMV006429 MMV006455 MMV006545 MMV006587 MMV006704 MMV006706 MMV006767 MMV006820 MMV006913 MMV006937 MMV007116 MMV007430 MMV007564 MMV007571 MMV007617 MMV007808 MMV007839 MMV007875 MMV007881 MMV007906 MMV007907 MMV007977 MMV007978 MMV008127 MMV008138 MMV008149 MMV008212 MMV008270 MMV008956 MMV009063 MMV009108 MMV011099 MMV011256 MMV011259 MMV011567 MMV011576 MMV011795 MMV011944 MMV018984 MMV019017 MMV019064 MMV019066 MMV019074 MMV019110 MMV019124 MMV019127 MMV019202 MMV019258 MMV019266 MMV019313 MMV019662 MMV019670 MMV019700 MMV019738 MMV019758 MMV019780 MMV019871 MMV020275 MMV020439 MMV020490 MMV020492 MMV020500 MMV020505 MMV020548 MMV020549 MMV020651 MMV020654 MMV020660 MMV020700 MMV056726 MMV075490 MMV084940 MMV142383 MMV274073 MMV306025 MMV390048 MMV396632 MMV396633 MMV396669 MMV396672 MMV396681 MMV396703 MMV396705 MMV396715 MMV396719 MMV396736 MMV396744 MMV396749 MMV396794 MMV396797 MMV403679 MMV665782 MMV665789 MMV665796 MMV665798 MMV665799 MMV665800 MMV665803 MMV665806 MMV665817 MMV665826 MMV665850 MMV665857 MMV665874 MMV665876 MMV665878 MMV665879 MMV665883 MMV665890 MMV665897 MMV665899 MMV665901 MMV665902 MMV665904 MMV665906 MMV665915 MMV665916 MMV665918 MMV665928 MMV665929 MMV665935 MMV665939 MMV665940 MMV665946 MMV665948 MMV665954 MMV665979 MMV666009 MMV666057 MMV666061 MMV666067 MMV666069 MMV666070 MMV666071 MMV666072 MMV666080 MMV666081 MMV666102 MMV666103 MMV666105 MMV666110 MMV666116 MMV666693 MMV667487 Myxothiazol NITD609 OZ277 OZ439 P218 Pyrimethamine SJ733 WR WR99210 Factors Drug:Antimycin_A Drug:Atovaquone Drug:AZ412 Drug:Chloroquine Drug:DDD498 Drug:Deoxyglucose Drug:DSM1 Drug:DSM265 Drug:ELQ-300 Drug:KAF156_analogue Drug:KAF246 Drug:MMV000248 Drug:MMV000356 Drug:MMV000483 Drug:MMV000498 Drug:MMV000561 Drug:MMV000563 Drug:MMV000620 Drug:MMV000634 Drug:MMV000653 Drug:MMV000662 Drug:MMV000760 Drug:MMV000788 Drug:MMV000848 Drug:MMV000963 Drug:MMV000972 Drug:MMV001038 Drug:MMV001049 Drug:MMV001230 Drug:MMV001246 Drug:MMV001255 Drug:MMV001344 Drug:MMV006087 Drug:MMV006188 Drug:MMV006278 Drug:MMV006319 Drug:MMV006427 Drug:MMV006429 Drug:MMV006455 Drug:MMV006545 Drug:MMV006587 Drug:MMV006704 Drug:MMV006706 Drug:MMV006767 Drug:MMV006820 Drug:MMV006913 Drug:MMV006937 Drug:MMV007116 Drug:MMV007430 Drug:MMV007564 Drug:MMV007571 Drug:MMV007617 Drug:MMV007808 Drug:MMV007839 Drug:MMV007875 Drug:MMV007881 Drug:MMV007906 Drug:MMV007907 Drug:MMV007977 Drug:MMV007978 Drug:MMV008127 Drug:MMV008138 Drug:MMV008149 Drug:MMV008212 Drug:MMV008270 Drug:MMV008956 Drug:MMV009063 Drug:MMV009108 Drug:MMV011099 Drug:MMV011256 Drug:MMV011259 Drug:MMV011567 Drug:MMV011576 Drug:MMV011795 Drug:MMV011944 Drug:MMV018984 Drug:MMV019017 Drug:MMV019064 Drug:MMV019066 Drug:MMV019074 Drug:MMV019110 Drug:MMV019124 Drug:MMV019127 Drug:MMV019202 Drug:MMV019258 Drug:MMV019266 Drug:MMV019313 Drug:MMV019662 Drug:MMV019670 Drug:MMV019700 Drug:MMV019738 Drug:MMV019758 Drug:MMV019780 Drug:MMV019871 Drug:MMV020275 Drug:MMV020439 Drug:MMV020490 Drug:MMV020492 Drug:MMV020500 Drug:MMV020505 Drug:MMV020548 Drug:MMV020549 Drug:MMV020651 Drug:MMV020654 Drug:MMV020660 Drug:MMV020700 Drug:MMV056726 Drug:MMV075490 Drug:MMV084940 Drug:MMV142383 Drug:MMV274073 Drug:MMV306025 Drug:MMV390048 Drug:MMV396632 Drug:MMV396633 Drug:MMV396669 Drug:MMV396672 Drug:MMV396681 Drug:MMV396703 Drug:MMV396705 Drug:MMV396715 Drug:MMV396719 Drug:MMV396736 Drug:MMV396744 Drug:MMV396749 Drug:MMV396794 Drug:MMV396797 Drug:MMV403679 Drug:MMV665782 Drug:MMV665789 Drug:MMV665796 Drug:MMV665798 Drug:MMV665799 Drug:MMV665800 Drug:MMV665803 Drug:MMV665806 Drug:MMV665817 Drug:MMV665826 Drug:MMV665850 Drug:MMV665857 Drug:MMV665874 Drug:MMV665876 Drug:MMV665878 Drug:MMV665879 Drug:MMV665883 Drug:MMV665890 Drug:MMV665897 Drug:MMV665899 Drug:MMV665901 Drug:MMV665902 Drug:MMV665904 Drug:MMV665906 Drug:MMV665915 Drug:MMV665916 Drug:MMV665918 Drug:MMV665928 Drug:MMV665929 Drug:MMV665935 Drug:MMV665939 Drug:MMV665940 Drug:MMV665946 Drug:MMV665948 Drug:MMV665954 Drug:MMV665979 Drug:MMV666009 Drug:MMV666057 Drug:MMV666061 Drug:MMV666067 Drug:MMV666069 Drug:MMV666070 Drug:MMV666071 Drug:MMV666072 Drug:MMV666080 Drug:MMV666081 Drug:MMV666102 Drug:MMV666103 Drug:MMV666105 Drug:MMV666110 Drug:MMV666116 Drug:MMV666693 Drug:MMV667487 Drug:Myxothiazol Drug:NITD609 Drug:OZ277 Drug:OZ439 Drug:P218 Drug:Pyrimethamine Drug:SJ733 Drug:WR Drug:WR99210 2-dehydro-D-gluconate -0.41 -0.05 1.05 0.95 0.65 0.1 -0.74 -0.3 0.7 1.28 -0.42 -0.61 -0.18 -0.18 0.59 -0.72 0.2 0.18 -0.85 0.24 0.48 0.36 -0.96 -0.46 0.32 0.2 0.28 -0.23 0.75 0.42 -0.69 -0.1 0.13 -0.64 0.11 -0.52 0.14 0.24 0.28 -0.32 0.11 -0.53 -0.09 0.31 0.09 -0.21 -0.35 0.38 0.44 0.6 -0.58 0.01 0.36 -0.71 -0.27 0.16 0.07 0.07 -0.75 0.26 -0.31 0.12 0.74 -0.02 -0.14 1.18 0.41 0.15 0.09 0.02 -0.52 0.96 -0.1 0.06 -0.14 -1.08 -0.26 0.09 -0.08 -0.03 0.03 0.85 0.17 -0.3 -0.42 -0.39 -0.26 -0.62 -0.33 -0.02 0.18 0.09 -0.49 -0.28 0.18 0.06 -1.29 0.05 -0.24 0.17 -0.33 0.18 0.1 -0.09 -0.06 -0.08 0.05 0.17 0.24 -0.66 -1.18 0.44 0.74 -0.14 0.38 0.17 0.01 0.8 -0.11 0.24 0.09 0.59 0.14 0.24 1.32 -2.02 -0.11 -0.22 -0.04 -0.28 -0.45 -0.01 0.12 0.03 0.49 0.02 -0.69 0.77 -0.13 -0.09 0.05 -0.03 0 0.61 -0.31 0.31 -0.31 -0.17 -0.37 0.08 0.5 -0.24 -0.48 0.05 0.2 -0.85 0.9 0.12 0.01 0.05 0.22 0.06 -0.01 0.79 -0.27 0.04 0.08 0.37 -0.3 -0.25 1.27 0.04 -0.7 -0.02 -0.54 -0.45 -3.63 0.62 -0.47 0.3 0.43 -0.46 0.7 0.61 0.75 0.22 -0.8 1.19 -0.22 -0.22 2-Hydroxy-2-methylbutanedioic acid 0.16 -0.04 -0.08 -0.13 0.02 0.07 -0.33 0.44 0.11 -0.07 -0.09 0.22 0.06 0.05 0.13 -0.57 0.01 -0.03 0.06 0.1 0.04 -0.04 -0.78 0.4 -0.06 -0.1 -1.86 -0.11 0.07 0.5 0.2 0.03 0.06 0.14 -0.09 -0.03 0.11 0.1 -0.54 0.04 0.15 -0.13 -0.11 0.2 -0.24 -0.13 -0.17 -0.05 0.03 -0.38 -0.58 -0.38 0.35 -0.06 0.05 0.03 0.08 0.09 0.01 0.09 -0.04 0.25 -0.07 -0.07 -0.08 -0.08 0.82 -0.05 0.1 0.11 -0.21 -0.71 0.02 0.36 -0.26 -0.13 0.71 0.49 -0.01 0.17 0.11 0.14 0.03 0.37 0.25 0.04 0.2 -0.41 0.43 0.36 -0.04 0.19 -0.07 -0.17 -0.03 0.07 -0.08 0.04 1.06 0 0.35 0.04 -0.31 0 -0.06 0.09 -0.18 0.02 -0.03 -0.08 0.17 -0.51 0.08 0.02 0.12 0.03 0.2 0.09 -0.02 0.02 -0.02 0.05 0.01 0.07 0.09 0.08 0.73 0.26 0.23 -0.05 0.22 0.07 -0.05 -0.18 0.1 0.05 0.1 0.66 0.22 0.61 0.09 -0.02 -0.18 0.15 0.04 0.43 0.11 0.08 0.5 0.25 -0.08 -0.15 -0.18 0.19 -0.52 -0.11 -0.19 0.04 -0.57 -0.25 0.85 0.43 0.32 0.03 0.13 0.14 -0.04 0.13 0.23 0.14 0.13 0.26 0.25 -0.17 -0.21 0.15 0.04 0.12 -0.05 0.12 -0.05 0.42 -0.18 -0.12 -0.07 -0.13 0.21 0.29 0.08 0.08 2-oxo-4-methylthiobutanoate -0.95 -0.04 0.23 0.86 0.01 0.74 0.34 0.31 0.25 0.14 -0.16 -0.4 -0.01 0.76 0.16 0.36 -6.77 -5.77 0.73 -0.03 0.55 -0.27 -0.47 0.73 -0.13 0.1 0.08 0.13 0.46 0.05 0 -0.68 0.66 -0.36 -0.12 -0.09 0.16 0.5 0.17 -0.07 0.61 0.34 0.25 0.41 0.08 -0.17 -0.26 -0.36 0.27 0.77 -0.26 -0.24 0.19 -0.13 -0.12 0.28 0.02 -0.35 0.18 0.15 0 0.24 -0.46 -0.34 -0.3 0.29 0.01 -0.09 0.76 -0.85 0.46 0.46 0.04 0.43 0.16 -0.35 1.03 -0.13 -0.15 0.4 0.11 -0.36 0.27 0.59 0.2 -0.1 0.27 0.46 0.33 0.37 -0.31 -0.33 0.39 0.02 0.01 -0.06 -0.3 0.07 0.4 0.07 0.3 0.09 -0.48 -0.07 0.2 -0.09 0.29 0.05 0.57 -0.47 -0.46 -0.05 0.24 -0.1 0.47 -0.53 0.84 0.27 0.24 -0.04 0.17 0.58 0.55 -0.22 -0.18 -0.33 0.35 0.38 0.41 0.23 0.01 0.3 0.76 0.69 0.23 0.21 -0.12 1.36 0.07 0.55 0.27 0.61 1.09 0.05 0.19 0.63 0.39 -0.26 0.09 0.25 -0.23 -0.52 0.3 0.63 -0.68 -0.67 -1 0.01 -0.27 0.26 0.72 -0.1 -0.18 -4.63 0.24 -0.36 0.5 0.09 -0.09 -1.27 -0.4 0.06 -1.08 -0.14 -0.47 -0.15 -0.1 0.1 -0.05 0.04 -0.08 -0.62 0.27 0.06 0.12 -0.25 -0.02 0.48 0.01 0.01 2_3-Diphosphoglyceric acid -1.13 -0.09 -0.68 -0.18 0.51 -2.82 -0.3 0.15 0.29 0.49 -0.78 -1.94 0.48 0.16 -0.21 -0.26 0.08 0.66 -0.12 -0.58 -1.11 0.87 -0.3 -0.98 -0.7 0.66 0.4 -0.35 -0.08 0.51 -0.41 0.04 -0.37 0.13 -0.27 -0.33 -0.9 -1.04 0.55 -0.16 -0.82 -0.31 -0.51 -0.2 -1.06 -0.01 -0.64 0.34 -0.03 0.11 -0.21 -3.86 -0.09 0.24 -0.31 -0.17 -0.33 -0.02 0.18 -1.54 -0.48 0.58 -0.1 -0.24 -0.23 1.01 0.9 -0.24 -0.02 0.22 -0.2 -0.48 0.19 -0.07 -0.84 -0.61 -2.52 -0.16 -0.25 -0.65 -0.14 -0.11 0 -0.49 -0.07 0.13 -0.75 -0.28 -0.26 -0.61 -0.23 0.18 -0.4 -0.24 -0.01 -0.23 0.08 0.19 -0.29 -0.32 -0.5 -0.03 -0.01 -0.25 -1.18 -0.18 -0.23 0.13 -0.09 0.03 0.37 -0.79 -0.63 0.28 -0.95 -0.01 -0.13 0.04 -0.28 -0.18 -1.51 -1.22 -0.06 0 -1.27 -0.23 0.49 -0.04 0.59 -0.19 -1.27 -0.77 -0.38 -2.84 -1.58 -0.61 -0.22 -1.31 0.89 -0.82 0.19 -0.35 -1.26 -0.03 -0.4 -2.64 -0.25 -0.09 0.11 0.08 -0.09 -1.14 -0.37 0.51 -2.49 -1.21 0.02 -0.06 -0.61 -0.25 0.63 0.06 -0.3 0.52 -0.56 -0.52 -0.28 -0.09 -0.84 -0.38 -0.13 -0.58 0.33 -0.3 -0.48 -1.19 -0.35 -0.07 -0.63 0.59 -0.05 -1 -2.14 -0.17 0.95 0.23 0.14 0 0.15 0.15 3-phospho-serine 0.18 0.01 -0.05 -0.22 0.1 -0.22 -0.2 -0.07 0.26 0.29 -1.02 -0.3 -0.82 -0.92 -0.06 -1.47 0.58 1 -0.33 0.78 -1.22 -0.13 -1.43 -0.49 -0.46 -0.13 0.04 -0.93 0.12 0.15 -0.01 -0.06 0.14 0.37 -0.1 -0.15 -0.45 -0.39 -0.35 -0.28 -0.17 -0.99 -0.2 -0.1 -0.21 -0.18 -0.06 -0.19 0.02 0.95 -1.25 -0.3 -0.18 -0.42 -0.43 0.02 -0.55 -0.18 -0.4 -0.43 -0.22 0.4 -0.15 -0.48 -1.22 0.48 0.61 -0.94 0.82 -0.04 -0.24 0.81 -0.77 -0.32 0.3 0.21 -0.69 -0.27 -0.13 -0.33 -0.31 -0.06 -0.46 -0.05 0.1 -0.73 -0.43 -1.43 -0.37 -0.18 -0.2 0.22 -1.05 -0.08 -0.62 -0.12 0.25 0.28 -0.18 -0.26 0 -0.14 -0.16 -0.38 -0.07 -0.04 -0.16 -1.23 -0.24 -0.01 0.44 -0.59 0.59 0.06 -0.98 -0.14 0.38 -0.08 0 -0.13 -0.13 -2.31 -0.14 -0.09 -0.74 0.29 0.02 -0.05 0.01 -0.64 -0.07 -0.36 -0.12 -0.54 -0.53 -1.36 -0.33 -0.15 -0.23 -1.55 0.24 0.36 -0.14 0.04 0.06 -0.11 -0.1 -0.12 -0.25 -0.29 0.08 -0.45 -0.24 0.24 -0.36 -0.16 -0.72 0.16 0.02 -0.61 0.13 -0.24 0.14 1.35 -0.26 0.14 -0.68 0.35 -0.07 0.04 0 0.08 0.29 -0.19 -0.2 -0.36 -0.17 -0.01 -0.74 0.34 -0.12 0.14 -0.02 0.48 -0.14 0.03 1.11 0.1 0.51 0.51 3-phosphoglycerate 0.16 0.08 -0.13 -0.22 0.08 -2.9 -0.41 0.19 -0.05 0.09 -0.44 0.53 0.69 0.33 -0.41 -0.18 -0.6 0.3 -0.17 -0.27 0.25 1.27 -0.51 -0.08 -0.15 1.23 0.56 -0.09 0.22 -0.31 -0.4 0.15 -0.11 0.18 -0.18 -0.41 0.15 0.34 0.48 -0.69 -0.56 0.12 -0.64 -0.24 -0.49 -0.13 -0.65 -0.18 -0.13 -0.53 -0.3 -0.32 0.07 0.91 -0.03 -0.21 -0.49 0.23 -0.42 -0.43 -0.25 0.33 -0.04 -0.33 -0.45 0.6 0.93 -0.05 -0.21 0.09 -0.89 -0.43 0.74 0.59 0.37 -0.48 -0.14 -0.42 -0.09 -0.49 0.28 -0.2 0.17 -0.55 0.62 0.41 -0.53 -0.21 -0.24 -0.44 -0.27 -0.42 -0.61 -0.4 -0.02 -0.29 0.06 0.09 0.07 0.09 -0.14 -0.11 -0.35 -0.04 -0.32 -0.17 -0.13 -0.08 -0.2 -0.45 0.23 0 -0.58 0.33 -0.1 -0.21 0.02 0.09 -0.08 -0.21 -0.51 -0.37 0.15 0.1 -0.3 -0.08 -0.33 0.19 1.04 -0.07 -0.09 -0.68 0.17 -0.77 -0.54 0.16 0 -0.31 0.19 -0.33 0.04 -0.3 -0.57 -0.16 -0.29 0.26 -0.12 0.01 0.14 0.09 -0.13 -0.06 -0.88 0.23 -1.2 0.37 0.15 -0.34 0.76 -0.39 0.27 -0.43 0.42 0.04 -0.58 0.16 -0.12 -0.25 0.23 0.1 -0.19 0.09 0.51 -0.44 -0.53 0.25 -0.19 -0.14 0.25 0.23 -0.31 0.36 -0.04 -0.01 0.13 0.19 0.07 0.15 0 0 4-aminobutyrate 0.36 0.34 -0.43 0.54 -0.46 0.26 0.01 -0.01 0.14 -0.2 -0.47 0.17 0.06 -2.26 -0.11 -0.41 0.29 -0.12 -0.08 0.47 0.26 0.56 -0.27 -0.31 0.07 -0.37 0.78 -0.52 -0.75 -0.06 0.05 -0.3 0.23 0.23 0.27 -1.09 0.79 0.44 0.46 0.18 -0.67 0.01 -0.31 0.18 0.25 0.55 0.37 0.09 0.61 -0.08 -0.07 0.59 -0.27 -0.86 0 0.55 0.19 0.43 -0.4 -0.36 -0.28 0.96 0.11 0.39 -0.29 0.73 0.28 -0.63 0.61 0.46 -0.13 1.17 0.16 -0.26 0.38 -0.46 1.12 -0.22 0.01 -0.67 -0.02 0.73 -0.04 -1.63 0.28 -0.05 -0.24 -0.3 -0.4 0.13 -0.14 0.08 -0.78 -0.14 -0.43 -0.42 0.04 -0.17 -0.24 -0.23 0.07 0.34 0.13 0.01 0.1 0.33 -0.06 -0.7 -0.02 0.25 -0.18 -0.09 0.06 -0.14 0.46 0.07 0.01 0.1 0.23 0.07 0.16 0.31 -0.32 0.58 0.97 -0.25 -0.47 -0.15 0.48 -0.92 0.41 -0.92 0.29 0.33 0.19 0.33 0.49 0.28 0.43 -1.22 0.42 0.43 0.36 -0.27 0.09 0.43 0.71 0.65 0.41 0.09 -0.38 -0.04 -0.14 0.3 0.24 0.15 -0.15 0.52 0.4 -0.35 0.01 -0.76 0.4 0.19 -0.55 0.33 -1.88 0.35 0.33 0.67 0.31 0.52 -0.4 -0.03 -0.3 0.26 0.69 -0.67 0.31 0.43 -0.02 0.21 -0.18 -0.48 0.13 -0.43 0.06 -0.31 0.89 0.89 4-phosphopantothenate -0.16 -0.24 0.15 -0.05 -0.32 -0.56 -0.54 -0.2 -0.35 0.04 -0.76 -0.47 -0.63 -1 -0.2 -0.12 -0.2 -0.43 0.27 0.03 -0.67 -0.54 -0.95 -0.54 -0.38 -0.28 0.77 -0.51 -0.46 0.09 0 -0.1 -0.47 -0.15 -0.11 0.02 -0.1 -0.62 0.37 -0.16 0.13 0.25 0.06 0.24 -0.48 -0.44 -0.39 -0.26 -0.3 0.2 -0.43 -0.54 -0.27 -0.55 0.39 -0.41 -0.48 0.12 -0.94 -0.53 -0.12 0.62 -0.26 0.41 -0.54 0.72 0.61 -0.6 -0.62 -0.39 -0.57 0.16 -0.47 -0.58 -0.02 -0.36 -1.05 -0.58 -0.02 -0.41 -0.57 -0.07 -0.53 0 -0.25 -0.54 -0.1 -0.01 -0.05 -0.31 -0.17 -0.37 0.25 -0.04 0.17 -0.91 -0.11 0.12 0.76 0.17 0.08 0.11 -0.09 -0.6 -0.23 -0.16 -0.22 0.15 -0.18 -0.58 0.44 -1 0.14 -0.28 -1.05 -0.07 -0.39 -0.09 0.2 0 -0.25 -0.5 0 -0.5 -0.35 0.08 0.56 -0.28 -0.12 -0.59 -0.58 -0.33 -0.06 -0.87 -0.36 -0.59 0.11 -0.05 0.09 -2.75 -0.32 -0.13 -0.45 -0.22 -0.31 -0.15 -0.03 0.19 0.27 -0.44 -0.3 -0.53 -0.31 0.14 -0.82 -0.33 -0.26 -0.54 -0.78 -1.11 0.76 -0.56 -0.1 0.25 0.11 0.11 -0.92 0.06 0.21 -0.02 0.35 -0.34 -0.16 -0.38 -0.25 -0.62 -0.04 0.08 -0.86 0.06 -0.16 0.42 -0.24 0.04 -0.04 0.05 0.16 -0.2 0.06 0.06 4-Pyridoxic acid -0.12 0.19 0 -0.05 0.19 -0.05 -0.16 -0.77 0 -0.61 0.12 -0.43 0.78 0.28 1.07 -0.26 0.2 0.88 0.02 1.21 -0.07 -1.59 -0.68 0 0 0 -1.72 0.48 0.41 0.24 -0.77 -0.11 -0.04 0.46 0.19 0.09 0.36 -0.08 -0.29 -0.15 -0.14 0.44 0.15 -0.36 0.44 -0.25 -0.63 0.05 0.19 1.02 0.43 0.05 0.04 -0.22 0.71 -0.3 -0.3 -0.39 0 -0.11 -0.32 0.16 -0.52 0.46 -0.62 1 1.9 -0.25 0.08 -0.02 -0.23 2.44 -0.34 0.14 -0.07 0 0.07 -0.01 -0.12 -0.6 -0.07 0.31 -0.22 0.13 -0.02 0.1 -0.48 -0.43 0.33 0.06 -0.18 -0.22 0.32 -0.25 -0.54 -0.1 0 -0.18 0.75 -0.12 -0.06 -0.03 -0.16 0 0 -0.06 -0.16 0.03 -0.11 -0.37 0 -0.16 -0.05 0 -0.12 -0.33 -0.01 0.17 -0.13 -0.12 0 -0.39 -0.02 1.33 0.02 0 0.81 -0.04 0.08 0.38 -0.15 -0.57 -0.15 -0.1 -0.09 0.45 1.6 0.41 0.15 -0.11 -0.15 -0.11 -0.03 1.2 0 0.38 0.12 0.36 0.59 -0.13 -0.65 0.07 -0.1 0.16 0.01 -0.67 1.51 -0.18 0.1 0.44 0.65 -1.04 0.24 -0.26 -0.23 -0.65 0.46 -0.32 -0.51 -0.13 0.33 0.24 0.12 0.01 -0.2 0.16 0.26 0.67 0.06 0.25 0.49 -0.23 0 -0.78 -0.17 -1.1 -0.04 -0.36 0 0 PRPP -0.21 0.71 0.02 -0.03 -2.06 -7.64 -0.35 0.48 2.85 2.44 -1.16 -1.61 -1.74 -1.26 0.2 -0.45 -0.37 -0.55 -1.17 -1.87 -0.38 2.14 1.07 -1.66 -4.21 -0.99 -0.07 -5.25 -0.09 -0.36 0.27 -0.34 0.37 -1.49 -0.24 -0.44 -0.72 -0.74 -0.92 0.1 0.48 -2.8 -1.04 1.52 -0.5 0.92 0.39 0.63 0.49 -2.97 0.26 -5.94 1.09 0.74 -2.94 0.45 -0.74 1.97 -3.61 -2.25 -1.49 0.26 0.13 0 -1.37 -0.02 -0.18 -1.36 0.31 -0.68 -0.88 -2.4 -0.26 -1.09 -1.17 -2.1 -1.16 -0.87 0.46 1.85 -0.68 0.1 -2.47 0.67 1.07 -2.21 -0.01 0.6 0.76 1.57 0.68 0.76 -0.88 -0.8 -0.56 -0.7 -1.81 0.75 -0.09 0.29 1.1 -0.4 1.65 -2.47 -4.89 0.72 0.6 -0.82 1.84 0.55 -0.1 1.51 0 -2.28 -2.51 0.14 1.28 -0.33 -0.02 0.95 -5.78 -3.19 1.78 -0.83 -0.62 -4.36 -1 1.41 -0.38 -1.68 -1.34 2.16 0.57 -2.99 -1.54 -2.88 -0.4 -0.33 1.99 -1.22 -0.59 -1.36 -2.44 0.09 0.69 -1.65 -0.76 -1.86 1.89 -0.47 -0.14 -2.15 -0.44 0.47 -0.92 -1.63 -1.06 1.68 -0.11 -1.27 2.11 -0.62 0.52 -0.97 0.4 0.25 -1.63 0.15 -0.29 -0.05 -0.24 0.8 0.21 2.41 -0.25 -0.55 -1.83 0.09 -3.68 1.24 -0.25 -1.16 0 -0.11 2.97 2.49 0.4 1.71 0.48 0.48 6-phospho-D-gluconate 0.09 0.05 -0.06 -0.08 0.16 -1.52 -0.25 0.18 0.19 0.09 -0.33 -0.07 0.13 0.26 -0.09 -0.13 -0.16 0.08 -0.02 -0.36 -0.37 0.16 -0.35 -0.16 -0.06 0.23 -0.45 -0.13 0 0.26 -0.06 0.02 -0.36 0.45 -0.17 -0.06 -0.1 -0.3 0.46 -0.8 -0.27 -0.02 -0.1 0 0.02 0.04 -0.12 0.08 0.15 -0.16 -0.06 -0.5 0.11 0.05 -0.01 0.13 -0.14 0.05 0.03 -0.48 -0.07 0.41 0.08 -0.03 -0.17 0.83 0.52 -0.08 0.11 0.2 -1.07 0.21 0.01 0.2 0.23 -0.28 -0.44 -0.18 0 -0.4 -0.17 -0.02 -0.03 0.01 0.04 -0.02 -0.34 -0.05 0.2 0 -0.13 -0.22 -0.22 -0.16 -0.14 -0.01 -0.11 0.07 0.17 -0.05 -0.37 -0.03 -0.14 -0.1 -0.38 0.11 -0.08 0.08 0.17 -0.41 0.09 0 -0.15 -0.03 -0.34 -0.15 -0.02 0.1 -0.09 -0.02 -0.36 -0.22 -0.04 0.02 -0.46 -0.08 0.12 0.05 0.17 0.03 0.46 -0.49 -0.12 -0.75 -0.44 -0.23 -0.01 -0.04 -0.1 -0.53 0.01 0.11 -0.43 -0.02 -0.17 -0.09 -0.08 0.13 0.15 -0.06 0.07 -0.22 -0.54 0.26 -0.32 -0.12 0 1.1 0.26 0.07 0.42 0.04 0.06 -0.07 -0.28 0.08 -0.04 0.33 -0.01 -0.05 0.05 0.18 0.26 0 -0.17 -0.15 -0.01 0.01 -0.06 0.49 -0.14 0.43 -0.26 0.15 0.05 0.1 0.09 -0.24 0.03 0.03 a-ketoglutarate -0.57 -0.11 0.07 -0.02 -0.29 1.14 -0.73 -0.01 0.01 0.16 0.49 -0.73 -1.14 -0.56 0.09 -0.03 -1.05 -1.56 -0.36 -0.64 0.44 -0.94 -1.17 0.03 -0.79 -0.42 -0.3 -0.9 -0.09 -0.33 -0.22 0 -1.01 -0.32 0.05 0.29 -0.41 0.29 -0.69 -0.91 0.79 -0.25 -0.09 0.59 0.2 -0.64 -0.52 -0.71 -0.5 -1.83 -0.54 -0.48 0.1 -0.18 -0.24 0.04 -0.64 0.14 -1.76 0.31 -0.06 -0.46 0.45 -0.05 -1.14 -0.25 -0.15 -0.82 -1.06 -0.51 -0.63 -0.13 -1.3 -0.39 -0.95 -0.74 1.12 -0.58 -0.07 0.12 -0.95 -0.02 -1.08 0.43 0.87 -0.87 0.18 0.31 0.24 0.21 -0.09 -0.63 0.46 -0.16 -0.55 -0.89 -1.26 0.02 0.14 -0.27 0.29 -0.13 -0.34 -0.86 -0.1 -0.3 -0.16 -0.35 -0.01 -0.94 -0.6 -1.18 0.05 -1.03 -0.48 -0.49 -0.64 -0.34 -0.21 0.06 -0.15 -0.59 0.28 -0.52 -0.3 -0.88 -0.22 0.23 -0.52 -0.11 0.14 0.35 -0.36 -0.15 0.45 -0.47 0.24 0.49 -0.08 0.32 -0.13 -0.09 -0.52 0.27 -0.7 0.1 0.22 0.28 0.1 -0.6 0.31 -0.99 -0.18 -0.33 -0.33 -0.93 -1.34 -0.53 -0.13 -0.11 0.21 -0.77 0.04 -1.55 0.33 -0.53 -0.3 -0.19 -0.03 -0.39 0.04 -0.15 -0.29 -0.06 -0.16 -0.28 0.11 -0.11 -1.12 -0.04 -0.03 -0.11 0.24 -0.24 0.21 -0.16 0.2 0.34 0.08 0.08 acetyl-CoA -0.78 -0.56 -0.18 -0.24 -0.35 -3.88 -0.32 0.76 -1.19 -0.07 -0.6 -1.02 -0.08 -1.15 4.89 -0.44 -2.37 0.72 -1.38 -0.34 0.18 0.24 -2.11 -0.37 -1.05 -0.87 -4.88 -0.13 1.35 0.43 1.02 -0.06 -1.81 0.5 -0.25 -0.15 -0.89 -0.14 0 -2.85 -1.32 -0.69 0.13 -0.23 -1.06 -2.06 0 -0.72 -1.37 -1.86 -1.3 -0.25 0.27 -0.53 -0.59 -0.45 -1.5 -0.06 -1.76 -1.48 -0.14 -0.45 4.32 -0.75 -1.58 -1.47 -0.47 -0.23 -1.13 -0.02 -0.98 -0.75 0.56 0.55 -0.07 -1 -1.27 -0.12 0 -0.16 -1.63 1.31 -0.46 -0.53 0.48 -0.47 -0.5 0.34 -1 -1.11 -0.16 -0.32 -0.86 0.23 -0.19 -1.26 -0.09 -0.47 -0.29 -0.1 0.43 -0.17 0.22 -0.5 -1.12 -1.3 0.16 -0.87 0.63 -0.9 -0.44 -0.36 -0.24 -0.08 -1.34 -0.17 -1.39 0.48 0 0.5 -1.21 -1.05 0.33 -0.09 -1.22 -0.23 0.13 0.61 -0.01 0.02 0.52 -0.06 -0.17 0.62 -0.44 -0.29 5.29 -0.48 -0.57 -1.95 -0.24 0 0 4.67 -0.45 0.06 0.43 1.11 -0.22 -0.36 4.23 0.05 -0.32 -0.48 -0.16 -1.01 -0.91 -0.86 -0.02 -1.24 -0.31 -0.71 0.37 0.62 -1.29 1.11 -0.55 -0.59 0.68 0.06 1.76 -1.81 1.55 -1.93 -0.39 -1.1 1.68 0.54 -1.65 -0.28 0.39 -1.41 0 -0.4 0.63 -0.43 0.2 -0.55 0.03 0.03 Acetyllysine -0.27 -0.04 -2.02 -0.3 -0.25 -2.99 -0.16 0 -0.19 0.11 -1.42 -2.74 -3.12 -2.92 0.54 -0.51 0 -3.26 -0.41 -3.32 -4.57 -0.27 -1.17 -2.56 -4.52 -1.4 -1.74 -1.75 -0.91 0.45 -1 -0.46 -0.67 -0.29 -0.27 0.23 -3.07 -4.88 -1.84 0.14 -1.31 -0.38 -1.37 -1.21 -0.59 -0.16 0 -0.1 0.16 -1.18 -0.11 -3.75 -0.9 -0.15 0.62 -0.63 -0.35 -0.39 -6.45 -2.5 -2.01 0.54 0.37 -0.16 0.17 -0.89 -0.97 -2.3 0.03 -0.6 -0.37 -2.78 -3.5 -2.45 -0.91 -0.83 -3.69 -1.35 0.08 -0.05 -0.79 -0.34 -1.69 -1.66 -0.62 -1.99 0.46 -1.27 1.27 -2.14 1.89 0.03 -1.3 -0.89 0.35 0.72 0.97 -0.01 -2.21 -0.11 -1.07 -2.64 0.26 -4.52 -3.37 -0.27 -1.26 0.28 -0.76 -3.73 0.18 -1.19 -1.19 -1.05 -2.55 -1.25 -0.34 -0.17 -0.27 -0.86 -3.75 -4.23 -1.47 -0.24 -3.54 -1.73 -1.56 -1.86 -2.21 -2.36 -7.09 -0.05 0.23 -4.25 -2.83 -2.88 -0.83 -3.4 -0.46 -4.39 -0.4 0.28 -3.83 0.19 -1.54 -3.09 0.29 0.07 -1.37 -1.47 0.27 -1.39 -0.18 0.36 -3.87 -2.95 -4.1 -0.65 -1.48 -1.15 0.24 -4.49 -0.33 -1.31 0.22 -0.19 -2.55 0.06 -0.15 -0.5 0.66 -0.22 -0.87 0.35 -0.26 -0.71 -0.28 0.32 -2.92 0.14 -0.05 -0.06 -3.8 0.11 -0.06 0.02 0.29 -4.35 0.3 0.3 aconitate 0.8 0.5 0.06 -0.4 0.53 -1.1 -0.84 0.5 0.66 0.08 -0.25 0.33 0.96 0.49 -0.45 -1.84 1.46 1.34 -0.06 3.34 0.59 1.3 -0.95 -0.04 0.25 0.29 0.4 -0.16 0.37 -0.1 -0.16 0.44 -0.09 0.71 -0.29 -0.35 0.48 1.23 -0.06 -0.05 -0.33 -0.12 -0.27 0.03 0.41 0.24 0.22 0.27 0.36 1.06 -1.27 0.54 -0.8 0.27 0.09 -0.03 -0.45 0.31 -0.1 0.9 -0.48 -0.99 0.13 0.05 -0.51 0.2 0.75 -0.32 -0.06 0.04 -0.17 0.83 0.56 0.62 0.87 0.21 0.1 -0.78 0.23 -0.07 0.06 0.29 -0.69 -0.25 0.08 1.02 -0.7 -1.38 0.43 0.34 0.03 1.81 -0.95 -0.2 -0.64 0.41 0.1 0.33 -0.36 -0.11 -0.07 0.04 0.23 0.11 0.55 0.56 0.16 -0.42 -1.07 1.84 0.21 -0.68 -0.15 0.24 -0.52 0.17 0.05 0.28 0.2 -0.25 0.39 -0.29 -0.48 -0.27 0.77 0.09 0.32 0.26 1.01 -0.07 2.12 -1.06 0.81 1.67 0.97 0.34 0.01 0.58 0.69 -0.06 0.26 -0.64 -0.06 -0.26 -0.23 1.68 0.11 0.41 0.92 0.67 -0.09 -0.42 -0.4 -0.09 -0.83 0.48 1.24 1.12 -0.93 0.02 -0.26 -0.37 1 1.18 -0.71 0.45 -0.3 1 0.32 0.48 -0.2 0.85 0.74 0.12 -0.07 0.49 0.06 -0.14 0.41 0.21 -0.5 0.55 1.38 0.6 0.36 0.24 0.44 2.23 -0.02 -0.02 adenosine 0.35 0.06 0 -0.76 0.39 -0.4 -0.21 -0.18 -0.19 -0.07 -0.42 0.09 0.56 -0.36 -0.57 -0.05 -1.29 -2.48 -0.25 -1.85 0.81 0.8 0.4 -1.35 -0.7 -0.06 -1.23 0.06 -0.39 0.14 0.07 0.14 0.25 -0.92 -1.5 -0.12 0.85 0.35 -1.93 0.55 -2 0.19 -0.16 -1.79 -2.06 0.48 0.35 -0.4 -0.4 -2.38 0.23 -0.26 -0.83 -0.49 0.27 -0.36 0.29 -0.25 0.67 -1.1 -0.12 0.7 -0.89 -0.27 0.8 -0.43 -0.88 -0.76 0.1 0.2 0.1 1.24 0.52 0.38 0.1 1.34 -0.47 -0.16 0.14 -0.21 0.23 -0.42 -1.09 -2.86 -0.54 0.41 -0.16 -0.52 -1.15 -1.11 -0.63 -0.57 -0.65 0.04 -0.6 0.24 1.31 0.36 -1.66 -0.33 -0.24 0.41 -0.03 -0.16 0.39 -0.25 0.3 -0.35 0.26 -0.33 0.72 0.2 -0.17 0.38 0.98 -0.02 0.04 0.06 0.1 0.06 0.13 0.32 -0.03 -1.51 -0.09 0.8 -0.58 -0.65 0.14 -1.61 0.43 -0.22 0.35 0.27 -0.09 0.03 -1.11 0.48 0.1 -0.18 0.03 -0.2 0.31 -0.48 -0.24 0.27 -0.26 -0.46 -0.26 0.1 -0.71 -0.17 0.07 0.91 -0.38 0.24 -0.96 -0.09 -0.02 -0.67 0.39 -0.06 -0.1 -3.35 -0.28 0.28 -0.92 -0.09 -0.2 0.1 -0.84 -0.05 -1.16 -0.22 -0.03 -0.04 -0.45 -0.05 0.07 -0.11 0.02 0.25 -0.1 -0.29 0.42 0.37 -0.2 1.11 -0.59 -0.59 ADP-D-glucose -0.14 0.03 -0.02 -0.17 -0.01 0.28 -0.12 0.02 0 0.03 -0.62 -0.57 0.1 -0.32 -0.84 -0.33 0.01 -0.23 -0.05 -0.25 -0.19 -0.03 -0.42 0 -0.14 0.18 0.41 -0.11 -0.21 0.26 -0.03 0.18 0.13 0.62 -0.31 -0.29 -0.12 -0.14 0.35 -0.03 0.17 -0.07 -0.31 0.07 -0.29 0.12 -0.14 0.17 0.36 -0.14 0.05 -0.24 0.1 -0.2 0 -0.15 -0.04 0.03 0.19 -0.4 -0.42 0.3 -0.37 -0.27 -0.07 0.14 0.23 -0.07 0.15 0.53 -0.21 -0.32 -0.24 0 0.12 0.32 0.36 -0.15 -0.06 -0.2 0.09 0.04 -0.04 0.15 0.36 0.07 -0.44 -0.55 0.18 0.14 -0.24 -0.09 -0.71 -0.25 -0.14 0.2 0.39 0.04 -0.09 -0.23 0.04 0.09 -0.27 -0.06 0.29 0.1 -0.1 0.01 -0.38 -0.5 0.62 -0.35 -0.17 0.23 0.04 0.19 0.15 0.25 -0.05 -0.27 0.06 -0.04 -0.36 -0.04 0.08 0.48 0 0.02 0.06 -0.4 -0.4 -0.6 0.02 -0.42 -0.62 -0.24 -0.05 -0.03 -0.08 0.13 0.02 -0.09 -0.61 -0.28 -0.24 -0.06 -0.07 0.11 0.38 -0.13 -0.12 -0.14 -0.23 0.17 -0.49 -0.53 -0.17 0 0.06 -0.51 0.52 -0.32 0.04 -0.04 -0.52 0.16 -0.69 -0.09 -0.12 -0.11 0.11 0.06 0.45 -0.04 -0.26 -0.2 -0.14 0.05 -0.09 0.35 -0.18 -0.15 -0.07 0.03 -0.1 -0.04 0.27 0.04 -0.24 -0.24 ATP -0.78 0.01 -0.13 -0.18 0.32 -4.03 -0.46 0.77 2.51 2.4 -0.79 -2.04 -0.01 0.04 0.01 -0.23 -0.42 0.6 -0.22 -0.98 -1.38 0.14 -0.71 -0.38 -0.97 -0.48 -0.82 -0.48 0 -0.32 -0.13 -0.05 -0.22 -0.21 -0.08 -0.19 -1.81 -1.34 0.33 -0.85 -0.17 -0.51 -0.24 0.01 -0.01 -0.2 -0.41 0.47 -0.3 -1.49 -0.13 -4.05 0.13 -0.08 -0.21 0.37 -0.23 0.08 -0.32 -2.34 -0.45 0.23 0.11 -0.05 -0.31 0.87 0.37 -0.25 0.23 -0.05 -0.14 0.73 -0.03 -0.11 -1.08 -0.63 -2.02 -0.37 -0.24 -0.38 0.01 -0.22 -0.25 -0.1 0.26 -0.48 -0.43 -0.12 -0.04 -0.04 -0.23 -0.16 -0.16 -0.24 -0.26 -0.14 -0.38 0.07 -0.98 -0.54 -0.32 -0.08 -0.3 -0.55 -2.9 -0.15 -0.27 -0.19 -0.16 -0.36 -0.25 -1.2 0 -0.36 -1.17 -0.41 0.07 -0.18 -0.43 -0.28 -2.79 -1.65 -0.01 -0.07 -2.6 -0.72 -0.65 0.05 0.02 -0.03 -2.39 -0.36 -1.03 -1.91 -2.2 -0.78 -0.13 -0.03 0.35 -1.69 0.15 -0.38 -2.89 0.16 -0.35 -0.54 -0.32 -0.33 1.45 -0.13 0 -1.55 -0.08 0.15 -2.51 -1.34 0.73 0.07 -1.21 0.08 0.72 -0.13 0.24 0.92 -0.24 -1.3 -0.05 -0.09 -0.27 -0.68 -0.15 0.69 -0.1 -0.29 -0.18 -0.03 -0.35 -0.17 -1.07 0.66 -0.01 -0.74 -2.32 -0.34 0.69 0.37 -0.03 -1.54 0 0 carnitine -0.94 0.1 0.57 0.64 0.04 0.97 0.05 0.43 0.57 0.2 1.21 -0.83 -0.36 0.11 0.66 -0.04 -0.2 -0.46 1.28 -0.38 0.25 -0.8 -0.47 0.84 -0.08 -0.21 -1.97 -0.24 0.12 -0.4 -0.26 -0.29 -0.16 -1.86 0.03 1.71 -0.25 -0.54 -1.52 -0.58 1.58 -0.14 1.08 0.45 0.7 -0.38 -0.2 -0.39 -0.26 -0.42 0.03 -0.6 0.46 0.41 -0.1 0.33 -0.9 0.11 -0.51 0.35 0.14 -0.15 1.05 0.18 -0.74 -0.77 0.03 -0.65 -0.66 -1.02 -0.51 0.39 -0.36 0.84 -1.08 -0.58 1.28 0.04 -0.19 -0.11 -0.36 -0.49 -0.94 1.19 1.14 -0.29 0.32 0.25 0.74 0.55 0.41 -0.63 1.93 -0.04 -0.64 -0.27 -0.59 -0.26 -0.47 0.38 0.79 -0.62 -0.21 0.01 -0.31 0.07 -0.22 -0.62 -0.09 -0.82 -0.52 -0.69 0.16 -0.38 -0.89 -0.29 -0.23 -0.78 -0.1 0.15 -0.2 -0.74 -0.04 -0.53 -0.56 -0.44 -0.97 0.47 -1.21 1.68 -0.86 0.16 -0.63 -0.94 0.79 0.07 0.43 0.45 -0.12 0.08 -0.06 0.04 -0.58 0.64 0.19 -0.04 0.8 -0.3 0.2 -0.17 0.53 -0.33 0.11 -0.41 -0.22 -1.27 -0.19 -0.05 -0.61 1.28 0.56 -0.06 -0.25 -0.83 0.45 -1.04 1.54 -0.19 0.01 -0.79 -0.6 0.11 -2.42 0.17 0.93 -0.56 -0.1 0.08 -0.65 0.05 0.39 -0.44 0.18 -0.16 0.05 0.86 -0.08 0.26 0.28 0.28 CDP -0.67 -0.57 0.18 0.11 0.52 -1.02 -0.79 -0.61 -0.7 0.02 -0.45 0.48 -0.09 -0.33 0.33 -0.36 -0.78 0.45 -0.08 0.43 -0.71 0.21 -0.27 -0.24 -0.67 -0.64 -0.14 0.15 -0.1 1.16 0.58 -0.21 0.3 -0.89 -0.18 0.09 0.81 -0.46 0.51 0.28 -0.28 1 0.09 0.03 -1.22 -0.99 -1.01 -0.7 -0.56 0.49 -1 0.58 -0.79 -1.96 -0.14 -0.8 -0.22 -0.46 -0.39 0.1 -0.48 0.68 -0.26 0.39 -0.26 1.06 0.51 0.24 -0.71 -0.69 -0.84 1.85 -0.02 -0.27 0.38 -0.67 -1.22 0.81 0.11 -0.33 -0.44 -0.25 0.1 -0.33 -1.84 -0.02 -0.07 -0.07 -0.41 -0.84 -0.01 0.59 0.57 0.87 0.46 -0.62 0.22 0.18 0.55 -0.11 -0.07 0.48 0.01 0.35 -0.2 -0.39 0.07 0.09 0.14 -0.22 0.26 -0.91 0.38 -0.43 -0.81 -0.07 -0.31 -0.3 0.16 -0.2 -0.47 0.18 0.16 0.27 0.13 0.35 0.68 0.31 0.13 -0.15 0.14 0.22 -0.43 0.33 0.29 -0.05 0.18 0.36 -0.07 0 -0.87 -0.84 0.16 0.28 0.58 0.54 0.52 -0.43 0.22 0.72 -0.03 0 0.24 0.24 0.85 0.18 0.17 -0.97 0.2 -1.3 0.56 0.75 0.7 0.29 -0.06 0.31 -0.26 0.62 0.23 -0.13 0.03 -0.64 0 -0.62 -0.14 -1.37 0.07 0.4 0.23 -0.77 0.16 -1.1 -0.21 0.11 0.03 0.61 0.17 -0.15 0.18 0.18 CDP-ethanolamine 0.03 -0.16 -0.23 0.73 0.13 -0.27 -0.61 -0.3 -0.35 0.06 -0.37 0.12 0.17 0.08 -0.07 -1.35 0.31 1.54 0.49 0.88 -0.31 -0.03 -1.3 0.06 1.02 0.68 -0.11 0.01 -0.08 0.33 -0.05 -0.11 -0.69 0.24 -0.03 0.25 0.02 -0.31 -0.18 -0.46 -0.31 -0.09 0.15 0.06 -1.02 -0.1 -0.92 -0.28 -0.26 1.36 -1.4 0.66 -0.13 0.05 0.14 -0.57 -0.19 0.11 0.77 -0.12 -0.09 -0.2 -0.7 -0.23 0.01 0.73 1.02 0.3 -0.61 0.51 -0.53 1.37 0.27 0.34 0.54 0.13 -0.45 -0.14 -0.02 -0.47 -0.7 0.09 -0.03 0.02 -0.35 0.15 -0.36 -1.36 0.02 -0.22 0.15 0.73 0.08 -0.09 0.16 0.01 0.29 0.14 -0.23 0.03 -0.17 0.7 -0.15 0.45 0.28 -0.19 -0.32 0.25 -0.31 0.6 0.52 -0.48 -0.18 0.53 -0.39 -0.06 -0.47 0.11 0.13 -0.09 0.55 -0.01 -0.43 0.07 -0.39 1 -0.03 0.04 0.11 0.53 1.02 -0.35 -0.25 -0.02 -0.24 -0.13 -0.08 0.27 0.1 0.37 -0.36 -0.09 -1.28 -0.11 0.02 0.59 -0.02 0.19 0.49 0.12 -0.2 0.55 -0.41 0.01 0.44 0.38 0.46 0.05 0.86 -0.06 0.55 -0.19 0.41 0.19 -0.33 0.34 0.11 0.27 0.12 0.03 0.02 -0.01 0.39 -0.43 0.07 -0.31 0.21 -0.06 0.64 0.38 -0.03 -0.03 -0.16 0.08 -0.09 0.23 1.31 -0.11 0.69 0.69 citrate/isocitrate -0.64 -0.21 0.5 0.23 -0.18 0.04 -0.69 0.77 0.16 0.38 0.33 -0.54 -0.24 0.1 0.6 0.06 -1.04 -0.23 -0.05 -0.64 0.06 0.01 -0.42 0.63 -0.18 -0.19 -0.77 -0.44 0.39 0.61 -0.13 -0.15 -0.57 -0.9 0.04 0.19 0.08 -0.09 -1.1 -0.74 0.67 -0.06 0.13 0.34 0.98 -0.53 -0.98 -0.72 -0.38 -1.43 -0.45 -0.53 0.23 0.38 -0.08 0.85 -0.43 0.26 -0.63 -0.1 -0.1 -0.15 0.84 0.5 -0.57 -0.7 0.25 -0.43 -1.28 -0.42 -1.31 1.57 0.02 0.49 -0.6 -0.8 1.1 -0.04 -0.23 -0.21 -0.84 -0.04 -0.25 0.66 0.49 -0.78 0.19 0.52 0.23 0.43 0.09 -0.35 0.45 -0.25 -0.34 -0.21 -0.63 -0.03 -0.99 0.06 0.7 -0.11 0.8 -0.27 -0.33 -0.13 -0.17 -0.47 0.91 -0.69 -0.65 0.92 -0.34 -0.48 -0.1 0.02 -0.68 -0.25 -0.03 0.45 -0.27 -0.18 0.29 -0.15 -0.1 -0.85 -0.74 0.63 -0.17 0.3 -0.33 0.09 -0.34 -0.89 0.18 0.26 0.68 -0.17 -0.68 -0.28 -0.16 -0.02 -1.16 0.73 -0.14 -0.48 0.22 -0.01 -0.21 0.02 -0.3 -0.33 0.13 -0.52 -0.28 -0.89 -0.24 -0.3 -0.39 0.27 0.44 -0.18 -0.58 -0.86 0.14 -0.46 0.44 -0.05 0.02 -0.63 -0.02 -0.51 0.01 -0.27 -0.06 -1.34 0.09 0.47 -0.52 -0.15 0.02 -0.4 -0.15 -0.24 0.19 -0.22 -0.26 0.95 0.01 0.01 CMP -0.25 -0.38 0.68 -0.84 1.15 -0.98 -1.86 -0.94 -0.15 -0.12 -0.26 0.15 -0.74 0.05 -0.04 -0.15 0.02 0.97 -0.01 2.25 -0.01 0.1 -0.16 -0.27 0.46 -0.13 -1.22 -0.97 0.01 -0.29 0.31 0.48 0.85 0.03 -0.43 -0.28 1.41 0.03 0.4 0.49 -0.37 0.26 -0.11 -0.02 -1 -0.33 -0.68 -0.08 0.03 -1.27 -0.69 1.7 -0.65 -0.4 -0.29 -0.86 -0.89 0 -0.48 1.09 -0.23 -0.2 -0.3 0.08 -0.92 3.53 1.44 0.36 -0.52 -0.07 -0.77 1.15 -0.15 -0.43 -0.22 -0.09 -0.24 0.53 0.28 -0.21 0.04 0.28 -1.06 -0.36 0.03 0.45 -0.09 -0.04 -0.01 -0.67 -0.27 0.2 0.33 -0.81 -0.31 -0.29 0.73 0.1 0.23 0.14 0.1 0.28 0.58 0.8 1.63 -0.11 1.16 0.1 0.5 -0.32 1.01 -0.91 1 0.09 -0.56 0.51 -0.12 0.53 -0.07 0.2 1.49 0.09 1.26 0.14 1.5 1.59 1.22 0.08 -0.05 -0.49 1.02 0.06 1.06 2.1 0.8 0.05 -0.28 0.91 0.01 0.9 -0.67 -1.16 1.32 -0.24 0.94 0.79 0.54 -0.23 0.34 0.36 -0.72 0.48 -0.94 -0.5 0.56 -0.37 -0.66 -1.18 1.54 -1 0.4 -0.15 1.02 1.51 -0.2 0.4 -0.43 0.24 0.59 0.17 0.36 -0.24 0.66 -0.68 -0.3 -0.05 0.25 0.21 -0.02 -0.31 0.08 0.04 1.33 0.71 0.37 0.38 0.01 1.24 -0.07 -0.07 CTP -0.76 -0.59 0.15 -0.81 0.89 -7.6 -3.14 -0.06 -0.37 1.09 -0.37 -0.33 0.54 0.35 0.12 0.03 1.04 2.36 0.24 1.73 -0.6 0.75 -0.2 0.05 -0.04 -0.33 -1.69 0.08 -0.26 0.01 -0.01 -0.76 -0.08 -0.41 0.22 0.01 -0.58 -0.53 0.46 -0.71 0.02 0.31 0.19 0.1 -0.69 -0.92 -1.57 -0.44 -0.08 0.91 -0.85 -0.84 -0.63 -0.28 0.16 -0.29 -0.72 0.01 -0.35 -1.92 0.03 0.5 -0.84 0.44 -0.69 1.03 1.78 -0.11 -0.65 -1.23 -0.68 2.11 0.52 0.18 -0.13 -1.11 -1.43 0.28 -0.33 -0.2 -0.05 0.42 0.04 0.19 -0.88 0.63 -0.2 0.21 -0.51 -0.53 -0.53 0.06 0.3 -0.1 -0.21 -2.06 0.1 -0.11 -1.45 -0.66 -0.21 0.18 0.04 -0.29 -1.33 -0.96 0.01 -0.24 0.15 -0.37 0.26 -0.77 -0.72 -0.04 -0.69 0.2 -0.05 -0.07 -0.5 0.12 -1.26 -0.61 0.16 -0.05 -1.73 -0.33 -0.22 0.24 0.34 0.18 -0.37 -0.36 0.05 -0.97 -0.14 -0.06 0.43 0.14 1.03 0.13 -0.94 -1.26 -1.41 0.41 0.11 -0.6 0.17 0.29 1.42 0.29 -0.36 -0.13 -0.07 0.41 -0.78 -0.44 2.63 -0.95 -0.05 -1.01 1.19 0.49 -0.27 2.63 -0.17 -0.64 0.22 0.11 -0.14 -0.53 0.05 -0.08 0.59 -1.11 -0.18 -3.08 0.39 -0.26 0.01 -0.29 0.2 -0.96 -1.5 0 0.32 0.18 -0.17 0.79 -0.11 -0.11 cyclic-AMP -0.02 -0.04 -0.05 -0.51 -0.47 -1.47 -0.91 -0.02 0.07 0.09 -0.43 -0.89 -0.73 -0.67 0.11 -0.02 -0.04 -0.86 -0.44 -0.92 -0.78 -0.75 -0.84 -0.53 -0.33 -0.85 0.85 -0.8 0.11 -0.2 -0.04 0.04 -0.41 -0.03 -0.03 0.02 -0.92 -0.8 0.15 -0.64 -0.04 -0.54 -0.05 0.03 -0.02 -0.16 -0.23 0.02 -0.1 -0.14 -0.25 -0.62 0.08 -1.05 -0.07 0.02 -0.19 0.19 -1.55 -0.47 0.02 0.22 0.11 -0.2 -0.22 0.78 0.42 0.02 -0.14 -0.11 -0.93 0.17 -0.95 -0.49 0.12 -0.25 -0.92 -0.26 -0.08 -0.38 -0.27 0.06 -0.6 0.11 -0.14 -0.69 -0.3 -0.02 0.17 0.07 0.05 -0.2 -0.13 -0.21 -0.2 -0.08 -0.35 0.07 1 -0.08 -0.2 -0.1 -0.22 -0.68 -0.89 0.18 -0.15 -0.06 -0.13 -0.81 0.02 -1.13 0.18 -0.53 -0.8 -0.08 -0.08 -0.12 -0.08 0.08 -0.95 -0.73 -0.06 0.17 -1.05 -0.3 0.54 0.07 -0.4 -0.54 -0.82 -0.19 -0.02 -1.21 -0.6 -1 0.07 -0.52 -0.02 -1.1 -0.13 -0.04 -1.13 0.18 -0.2 -0.14 -0.3 -0.02 0.22 -0.48 0.04 -0.37 -0.36 0.16 -0.97 -0.58 -0.96 -0.6 -0.1 -0.37 0.43 -0.92 0.35 -0.37 -0.15 -0.04 -0.47 -0.23 -0.22 -0.14 0.13 0.11 -0.06 -0.22 -0.11 -0.3 -0.06 0.09 -0.76 0.45 -0.04 0.33 -0.82 0.13 0.06 -0.02 0.06 -1 0 0 cytidine 0.14 0.34 -0.12 1.25 0.05 0.59 2.14 0.19 -0.22 -0.24 0.29 0.5 0.16 0.58 -0.26 -0.32 -0.12 1.44 -0.35 0.35 0.76 0.2 -0.11 0.72 0.16 -0.84 0.32 0.33 -0.13 -0.11 0.03 -0.28 0.47 -0.66 -0.18 -0.1 0.34 0.53 1.29 -0.62 -0.24 -0.34 -0.09 0.04 -0.48 -0.16 0.27 0.32 0.03 0.75 -0.25 -0.31 0.63 0 -0.08 -0.13 -0.8 0.59 0.63 0.34 -0.2 -0.25 -0.06 -0.15 -0.95 0.6 0.71 -1.24 0.77 -0.19 0.18 0.68 0.32 0.87 -1.69 0.02 0.91 -0.75 0.1 -0.49 0.16 -0.74 -0.27 0.03 0.54 0.27 -0.76 -0.19 0.35 0.26 -0.01 -0.14 -0.29 -0.34 -1.07 0 0.18 -0.06 -0.15 -0.11 0.24 -0.2 -0.36 0.42 -0.25 0.23 -0.29 -1.61 -0.15 -0.26 0.13 -0.3 -0.38 0.23 0.06 -0.19 0.64 -0.24 -0.17 -0.3 -0.05 0.13 -0.2 -1.06 0.5 0.39 -0.83 0.48 0.16 0.22 0 -0.25 -0.49 -1.34 0.85 0.17 -0.31 0.43 -0.15 0.04 -0.04 0.3 0.17 -0.22 -0.39 0.63 0.53 -0.46 0.04 0.33 -0.57 -0.5 -0.25 -0.13 -0.52 0.46 1.05 -0.16 -1.26 0.37 -0.09 0.41 0.13 -0.48 -1.26 0.06 0.52 -0.41 -0.44 -0.17 -1.01 0.09 -0.47 -0.16 -0.33 -0.05 -0.36 -0.14 0.35 0.35 0.07 0.2 -0.07 -0.07 -0.13 -0.11 0.15 -0.33 0.06 0.06 D-gluconate -0.12 0.12 -0.12 -0.07 0.04 0.43 -0.36 0.14 -0.13 -0.13 -0.19 0.2 0.03 0.35 0.12 -0.18 -1.14 -0.88 -0.21 -1.38 0.09 0.39 -0.25 -0.11 -0.46 -0.38 1.74 -0.09 0.39 0.14 0 -1 -0.19 -0.12 -0.05 0.23 0 0.1 1.2 -0.33 -0.47 -0.33 -0.08 -0.01 0.13 -0.05 0.1 0.12 -0.09 -2.47 0 0.04 0.43 -0.15 -0.07 0.27 0.71 0.1 -1.18 0.5 -0.28 0.08 0.31 0.02 0.34 1.16 1.14 -0.62 -0.3 -1.7 -0.3 0.41 0.28 0.23 0.26 -0.33 -1.22 -0.1 0.01 -0.22 -0.3 0.35 -0.05 -0.74 0.26 0.04 -0.3 -0.06 0.42 -0.17 0.27 0.22 0.05 -0.17 0.3 -0.44 -0.24 0.13 -0.08 0.28 0.03 -0.39 0.22 -0.23 -0.51 0.02 0.3 1.1 0.28 0.21 0.03 0.18 -0.22 -0.25 0.12 -0.16 -0.33 -0.01 0.53 0.22 -0.69 0.7 0.53 0.24 0.01 -0.18 -0.05 0.73 0.32 0.53 0.37 0.07 0.2 0.07 0.75 0.28 0.23 -0.22 -0.06 -0.21 0.02 0.01 -0.31 0.18 -0.22 -0.13 0.5 0.08 0.28 0.32 0.14 0.15 -0.25 0.06 -0.16 -0.26 0.03 0.35 0.33 0.47 0.31 0.02 0.34 -1.6 -0.27 -0.02 0.6 0.41 0.04 -0.19 0.05 0.24 0.08 -0.19 -0.45 0 0.57 0.1 -0.03 0.53 -0.04 0.09 -0.3 -0.01 -0.19 0.17 0.03 -0.42 -0.06 -0.06 D-sedoheptulose-1/7-phosphate -0.21 0.14 0.4 0.08 -0.02 2.38 -0.02 0.34 0.35 0.15 -1.01 -0.13 -0.34 -0.54 0 -0.11 1.81 1.93 -0.18 0.82 -1.12 -0.51 -0.17 -0.47 -0.7 0.21 0.33 -0.25 -0.26 0.96 0.07 -0.24 -0.4 -0.3 -0.25 -0.33 -0.28 -1.19 0.22 -0.22 -0.5 0.18 -0.55 0.09 -0.03 -0.42 0.11 -0.06 -0.08 1.13 0.09 -0.99 -0.04 -0.16 -0.38 0 0.36 -0.23 -0.06 -0.23 -0.76 0.41 -0.13 0.08 0.44 0.17 -0.56 -0.07 0.02 0.19 0.23 -0.57 -0.33 -0.37 -0.39 -0.57 -0.67 0.05 0.11 -0.14 -0.56 -0.17 0.27 -0.21 -1.03 -0.08 -0.14 0.16 0.06 -0.2 -0.17 0.83 -0.05 0.62 0.36 0.13 -0.12 0.09 1.18 -0.32 -0.22 0.04 -0.31 -0.37 -0.65 0.07 -0.22 0.45 0.78 0.34 0.01 0.57 0.22 -0.56 -0.55 -0.47 -0.19 -0.27 0.03 -0.33 -0.5 -0.22 -0.48 0.13 -0.45 -0.08 0.67 -0.25 -0.44 -0.43 -0.48 -0.14 -0.34 -1.21 -0.84 -0.35 -0.94 -0.65 -0.53 0.44 -0.21 0.1 -0.58 0.01 0.04 -0.91 -0.07 -0.2 -0.15 0.37 0.16 -0.02 0.27 0.18 -0.43 -0.53 0.67 0.33 -0.57 -0.35 -0.01 0.22 -0.56 2.25 -0.02 0.1 -0.31 0.65 0.21 -0.27 0.23 -0.21 -0.61 0.41 -0.16 -0.7 0.12 0.2 -0.03 0.39 -0.04 -0.26 -0.73 0.6 0.16 0.29 0.1 -0.25 0.03 0.03 dAMP -0.19 0.07 0.2 1.78 0.06 6.74 1.72 0.15 0.16 -0.07 1.95 -1.12 -0.79 -0.49 0.75 0.08 0.02 -0.37 -0.19 2.57 2.3 1.07 -0.69 0.28 0.12 -1.04 0.66 1 0.68 0.56 0.12 -0.6 1.73 -1.29 -0.26 -0.06 2.31 2.29 1.16 1.01 0.24 2.22 0.28 0.21 0.12 0.14 -0.09 -0.42 -1.44 0.41 -0.01 2.47 -0.13 -1.54 1.38 -0.32 0.11 -0.05 -0.04 2.94 0.01 0.61 -1.47 1.28 0.08 1.24 0.92 0.6 -0.08 -1.42 -0.76 2.62 0.9 -0.55 0.26 -0.12 2.39 0.73 -0.34 -0.76 0.17 -0.22 0.04 0.15 -1.83 1.21 -0.6 -0.41 0.13 -0.29 0.01 -0.09 1.13 0.67 0.74 -1.31 -0.07 0.06 1.81 0.45 0.7 0.43 -0.58 0.34 2.36 -3.15 -0.55 0.1 -0.34 -1.38 0.47 -0.6 0.13 -0.18 2.27 -0.32 -0.15 -0.22 0.7 -0.34 2.31 2.57 -0.32 0.3 2.44 0.4 0.54 0.12 0.36 0.2 1.49 -0.18 -0.58 2.55 2.79 3.18 0.3 2.45 0.28 0.22 -0.05 0.6 2.61 0.03 0.45 2.3 0.87 -0.05 0.32 -0.23 -0.36 0.29 -0.47 0.53 2.14 -0.36 -0.76 -1.78 -0.15 -0.06 1.14 -1.06 0.39 -0.25 -0.01 0.4 -0.54 0.16 -0.06 -0.36 0.39 -0.01 0.55 0.18 -0.41 -0.5 0.23 0.94 -1.25 -0.09 0.68 0.08 2.28 0 0.01 0.63 -0.35 2.12 -0.3 -0.3 dATP -0.08 0.22 1.32 -0.8 0.31 -4.13 -0.31 2.7 2.11 2.9 0.1 -2.22 0.08 -0.33 0.05 -0.06 -0.73 -0.67 0.15 -3.28 0.07 0.66 -0.48 -0.2 0.39 0.35 -1.25 -0.37 0.25 -0.23 0.79 -0.04 -0.2 0.4 0.14 0.08 -0.21 0.01 -1.01 -0.44 0.07 -0.07 0.07 0.07 0.58 0.2 0.08 0.33 0.18 -3.32 0.25 -1.98 0.41 -0.1 0.35 0.94 0.04 -0.02 0.84 -1.13 -0.04 0.17 0.45 0.29 -0.13 0.66 0.11 -0.02 0.54 0.36 0.05 1.43 0.44 -0.23 -0.51 -1.58 -1.3 0.15 -0.08 -0.34 -0.04 0.1 -0.44 0.24 0.53 0.05 -0.27 0.25 0.4 0.45 -0.16 -0.29 0.12 -0.21 -0.22 0.09 -0.08 -0.01 -0.47 -0.35 -0.21 0.19 -0.02 0.08 -0.85 0.22 -0.1 -0.16 0.06 -0.2 -0.53 -0.44 0 -0.41 -0.6 0.17 0.05 0.15 -0.39 0.12 -0.1 -0.09 0.11 -0.24 -0.97 -0.75 -0.66 0.13 0.08 -0.16 -0.98 -0.36 0 -1.78 -0.68 -0.18 0.3 -0.61 -0.27 -1.4 0.31 0.32 -1.56 0.32 0 -0.33 0.02 0.1 0.24 -0.55 0.29 -0.66 -0.13 0.15 -0.77 -0.73 -1.75 0.39 -0.38 0.72 0.21 -0.54 0.02 -1.57 -0.08 -0.36 -0.36 -0.13 -0.22 -1.09 0.06 0.43 0.56 0.21 -0.17 -0.26 -0.04 0.08 -0.59 0.77 0.15 0.16 -0.84 0.47 1.53 1.44 0.17 2.22 -0.89 -0.89 dCDP -0.47 0.12 -0.06 0.53 0 3.71 -0.15 -0.15 -0.3 0.12 0.04 0.71 -0.39 -1.44 0.47 -0.49 0.15 1.1 -0.15 2.67 0.58 1.11 0.47 -1.85 0.02 -0.46 0.96 -0.56 -0.03 2.83 0.58 -0.19 0.51 -0.37 -0.11 -0.1 2.48 0.78 0.73 0.92 -2.3 0.78 -0.16 -0.17 -2.53 -0.16 -0.78 0.05 -0.05 0.71 -0.24 1.68 -0.46 -2.14 -0.03 -1.05 0.3 -0.51 0.14 1.52 -0.51 1.04 0.16 0.07 0.5 1.56 0.94 0.25 0.13 -0.05 0.12 3.31 -0.76 -0.7 0.21 0.07 -1.19 0.83 -0.25 -0.33 -0.19 -0.12 -0.16 -0.61 -1.35 -0.89 -0.1 -0.54 -0.59 -0.99 -0.04 0.5 0.14 1.24 0.45 0.1 0.68 0.24 1.25 0.61 0 0.51 -0.11 0.53 1.62 0.15 0.21 0.39 -0.13 -0.25 0.52 -0.28 0.25 -0.05 0.34 0.27 -0.05 -0.36 0.04 -0.24 1.64 1.89 0.11 0.23 1.74 0.81 1.16 1.11 -0.34 -1.22 1.03 0.19 0.25 1.06 1.43 -0.59 0.28 1.23 -0.14 0.29 -0.37 -0.45 1.35 0.31 0.42 0.89 0.45 -0.4 0.1 0.99 0.3 0.14 0.28 0.63 1.25 -0.42 0.37 -0.51 0.27 -2.05 0.41 0.13 0.43 1.18 -0.06 0.12 -1.24 0.65 0.57 -0.12 -0.07 -0.15 0.85 0.11 -0.27 -0.61 0.09 0.56 0.21 0.3 0.14 -0.55 1.39 -0.04 0.08 0.54 0.28 1.5 0.46 0.46 dCMP -0.07 0.07 -0.08 -0.74 0.08 3.87 -1.1 -0.19 -0.2 -0.34 0.57 0.08 -1.96 -0.58 -0.03 -0.4 -0.7 -0.67 -0.4 2.49 1.06 -0.93 0.14 -0.27 0.32 -0.64 -0.63 -1.09 0.06 1.32 0.15 -0.03 0.42 -0.18 0.05 -0.73 1.4 1.17 -0.67 -0.01 -0.27 -0.69 -0.42 -0.2 -3.71 -0.5 -1.28 0.43 0.21 -3.41 -0.59 1.16 -0.46 -0.86 -0.83 -3.76 -0.16 -0.33 -0.5 2.24 -0.72 0.15 -0.79 -0.16 0.01 4.62 4.94 0.43 -0.59 0.22 -0.3 7.62 -1.76 -0.64 -0.93 -0.01 0.83 0.63 -0.49 0.14 -1.07 -0.22 -0.45 -0.54 0.07 -2.19 -0.51 0.11 -0.22 -0.43 -0.09 0.38 0.59 -0.14 0.35 -0.04 1.01 0.13 0.9 0.58 0.22 0.86 0.23 0.51 2.25 0.11 0.09 0.31 0.09 0.08 0.83 -0.21 0.1 -1.02 0.78 0.23 -0.67 -0.19 -0.61 0.06 1.66 1.45 0.45 0.44 2.1 1.3 1.35 0.99 -0.37 -0.72 1.37 0.25 0.3 0.87 1.74 -0.21 -0.42 1.19 -0.11 1.78 -0.06 -0.91 1.54 -0.07 -0.3 0.92 0.46 -1.64 0.01 0.55 -0.51 -0.29 -0.29 -0.13 -0.97 -0.39 -1.72 -0.42 -0.55 -0.65 0.39 -0.1 0.11 1.1 0.31 0.29 -0.53 0.81 0.51 0.1 -0.17 0.03 0.92 -0.29 -0.51 -0.29 -0.96 0.31 -0.49 0.25 0.16 0.04 0.94 -0.34 -0.3 0.62 0.14 2.2 0.32 0.32 dCTP -0.53 -0.21 0.21 0.22 -0.07 -2.99 -2.55 0.8 0.13 1.06 0.42 -0.07 0.1 -0.41 -2.69 0.05 -0.86 -1.16 0.15 -0.56 0.75 1.67 0.68 -0.01 0.68 0.79 -4.3 -0.78 -0.76 2.7 0 -0.03 -0.12 0.71 0.59 -0.57 0.28 0.79 -3.57 -0.37 0.17 -0.18 0.09 0.14 -0.03 -0.06 -0.66 0.14 0.77 -3.62 -0.04 -0.33 0.05 -0.58 0.55 0.44 0.01 0.01 0 0.53 0.06 0.46 0.19 0.32 0.05 -0.1 -0.48 -0.09 -0.07 0.49 0.05 1.14 -0.1 0.06 0.04 -0.63 -0.45 0 -0.24 -0.32 0.08 0.17 -0.06 0.34 -0.4 -1.02 -0.14 0.15 0.33 0.24 0.5 -0.09 0.14 0.36 -0.21 0.11 -0.08 -0.03 -0.94 0.7 -0.3 -0.22 -0.09 -0.9 0.3 0.17 -0.16 -0.1 -0.13 -0.52 0.66 -0.06 -0.73 -0.74 0.24 0.2 0.08 -0.3 -0.25 0.15 1.22 0.93 0.02 -0.09 1.54 -0.41 -0.53 1.47 -0.15 -0.9 0.32 -0.5 0.03 -0.08 1.27 -0.63 -0.75 0.33 0.15 -0.89 -0.13 -0.27 -0.26 -1.38 -0.31 -0.5 -0.57 1.07 1.74 0.54 -0.88 -0.26 0.02 0.41 -0.46 -0.77 -2.59 -0.44 -0.13 -0.34 0.6 0.01 -0.1 -1.27 0.04 -0.02 -0.39 0.03 0.09 -0.28 -0.02 -0.5 2.24 -0.3 -2.5 -2.14 -0.11 -0.18 -0.21 -0.33 -0.54 -0.51 -0.15 -0.04 0.92 -0.23 -0.26 2.24 0.42 0.42 deoxyinosine -0.53 0.2 0.37 0.3 -0.25 5.39 -1.04 -0.18 0 -0.94 2.88 -2.08 -3.98 -3.14 0.3 0.09 0.41 -0.15 -1.44 1.51 1.85 -3.88 0 0.08 -4.59 -2.24 0.44 -2.46 0.26 -1.37 -0.06 0.13 -1.89 -2.9 -0.46 0.55 1.28 1.62 -0.35 -1.78 0.66 -0.79 -1.51 0.27 1.07 -4.3 0.47 -0.51 -0.15 0.16 -0.54 1.02 0.66 -0.48 -0.82 0.59 -0.07 -0.1 -4.08 3.64 1.26 -0.31 0.86 0.03 -0.48 -0.56 1.1 -0.24 -1.99 -1.9 -0.05 2.8 -1.38 -0.57 -1.36 -1.27 1.65 0 -0.17 0 -2.96 -0.55 -1.06 0.4 1.6 -1.45 0 1.98 -0.65 0.94 1.19 -1.43 -1.44 0 -0.27 -0.94 -1.17 -0.15 -0.47 -1.98 0.76 -0.62 -0.36 -1.58 2.23 0.74 -0.4 -0.54 1.41 -2.33 -1.63 0 0 -2.75 0.3 0 -2.04 -0.94 0.21 0.11 1.9 1.49 1.38 -0.19 2.3 0 -0.74 -1.23 -0.72 -0.83 0.9 0 -2.02 0.84 4.19 -0.74 0.31 1.75 -0.17 0 0.03 0.88 1.34 0.29 0 1.36 0.1 0.04 0.07 0 0.38 -1.8 0.19 -0.54 1.37 -1.36 -0.36 0.13 -0.71 0.51 0.2 0 -0.3 -0.73 0 -0.68 -0.99 0.01 -0.21 -0.77 -0.45 0.22 -4.51 0 0.09 -0.15 0.33 -0.11 -2.38 0.3 0.06 -0.16 1.42 -0.31 5.31 2.38 0 1.51 0 0 deoxyribose-phosphate -0.01 -0.12 0.04 0.02 0.11 1.18 0.18 -0.03 -0.05 0.47 -0.92 0.71 -0.17 1.07 0.09 -0.18 -0.15 1.16 0.28 -0.97 0 0.01 -0.61 0.64 -0.09 2.77 0.33 -0.2 0.24 0.22 -0.13 -0.19 -0.17 -0.99 0.22 -0.04 -1.85 0 0.43 -0.3 -0.14 0.64 0.19 -0.24 0.06 -0.42 -0.62 0.11 0.03 0.09 -0.4 -0.44 -0.63 0.57 0.48 0.64 0.16 0.64 2.57 -0.22 -0.07 0.13 -0.45 -0.06 0.69 0.29 0.84 0.75 -0.27 -0.85 -0.72 -0.65 0.28 0.55 -0.63 0.13 -0.9 -0.1 0.1 -0.14 -0.09 0.25 1.28 -0.06 -0.42 -0.4 -0.26 -0.06 -0.55 -0.82 0.73 0.29 0.38 0.07 0.81 -0.53 2.12 0 0.8 0.71 -0.26 -0.13 0.12 1.22 -0.47 0.32 0.37 0.95 0.05 0.05 1.78 -0.32 0.63 1.73 0.39 0.14 0.26 0.12 -0.15 0.15 -0.48 0.08 0.6 0.8 -1.31 2.19 2.01 -0.21 0 0.76 0.91 -0.34 0.13 -1.71 0.49 0.47 0.18 -0.06 -0.14 -1.42 0 -0.57 -1.47 0.16 0.38 -0.1 0.16 0.36 -0.2 0.35 0.02 0.77 -1.05 -0.21 -1.15 0.54 0.69 0.43 0.36 0.46 0.19 0.36 0.04 0.94 -0.37 0.22 0.77 0.66 0.02 0.02 -0.16 0.01 -0.2 -0.51 -0.01 -0.52 0.04 0.1 1.31 0.03 -0.11 0.17 0.14 0.42 0.23 0.75 0.44 -0.52 -0.57 -0.57 dGMP/AMP -0.38 -0.09 0.16 0.12 -0.24 2.25 0.03 -0.13 -0.09 -0.11 -0.64 -0.46 -0.44 -0.2 0.15 -0.18 -0.46 -0.42 -0.37 -1.13 -0.62 -0.18 -0.38 -0.32 -0.74 -1.22 0.47 -0.21 -0.13 0.55 0 -0.26 1.37 -0.31 -0.35 -0.16 -0.99 -0.66 0.47 0.48 0.11 0.05 -0.21 0.1 -0.33 -0.14 -0.21 -0.37 -0.25 -0.24 -0.18 -0.52 0.14 -1.78 -0.3 -0.18 0.35 -0.25 -0.77 -0.36 -0.28 0.61 -0.11 -0.15 0.39 0.55 0.38 0.45 -0.03 0.01 -0.55 -0.91 -0.01 -0.21 0.4 -0.42 -0.28 0.11 0.09 -1.22 0.02 -0.23 0.15 -0.09 -0.34 -0.47 -0.88 -0.3 0.17 -0.12 0.06 -0.09 0.44 0.45 0.56 -0.28 -0.08 0.1 1.37 -0.06 0.3 0.3 -0.18 0.05 -0.98 -0.3 -0.59 0.14 -0.32 -0.57 -0.04 -1.4 0.03 -0.41 -0.14 -0.39 -0.09 -0.15 0.41 -0.3 -1.02 -0.39 -0.38 0.43 -0.74 0.01 0.14 0.05 0.18 -0.04 -1.66 -0.47 0.02 -0.8 -0.68 -0.01 -0.2 -0.99 0.05 -1.08 0.07 0.04 -1.27 -0.1 0.28 -0.83 0.05 -0.32 0.29 0.09 -0.08 0.47 -0.53 0.36 -0.82 -0.46 -0.19 -0.36 -0.13 -0.41 0.88 -0.32 0.82 -0.12 -0.23 0.2 -0.24 0.15 -0.12 -0.46 0.13 -0.3 0 -0.2 -0.32 -0.82 -0.09 0.09 -0.05 -0.22 -0.19 -0.16 -1.05 -0.14 -0.02 0.01 -0.07 -1.07 0 0 dihydroorotate 4.11 4.22 -0.26 -0.08 -0.4 -1.32 2.67 4.54 4.5 -0.11 -1.99 -0.4 -1.25 -1.09 0.62 -0.16 4.28 -1.16 0.42 -0.85 -3.59 2.77 2.71 -1.64 2.1 -0.97 2.22 -1.03 1.95 0.85 -0.15 1.01 0.15 5.42 0.1 0.14 -2.58 -3.67 -1.04 2.83 2.62 -0.95 -0.3 0.12 4.71 4.01 2.76 3.79 5.24 0.45 3.67 -1.38 5.13 -1.42 3.54 4.43 4.7 0.65 2.72 -0.12 -0.06 0.21 4.4 -0.07 4.41 1.19 -0.33 1.55 4.16 5.4 4.07 -1.31 -1.29 1.79 0.59 4.59 -1.9 0.79 0.24 1.03 1.07 1.63 -0.55 1.55 5.2 -0.05 0.48 -0.25 5.09 4.85 1.1 0.45 0.04 0.62 0.27 4.91 -0.53 0.28 0.16 0.07 0.11 2.26 0.71 0.01 -1.39 4.26 -0.07 -0.02 -0.37 3.15 0.2 -0.34 -0.46 -0.65 -1.15 0.64 1.31 2.79 1.74 0.12 -1.38 -1.34 -0.79 0.52 -2.58 -0.57 0.95 0.04 -0.94 -0.7 -1.18 -0.15 -0.34 -1.54 -2.07 -1.6 -0.04 -2.09 1.2 0.11 5.4 2.97 -1.93 -0.28 -0.06 -2.18 -1.46 0.2 0.25 -0.61 4.26 -1.02 -0.47 0.19 -2.24 -0.51 -0.96 5.37 0.95 4.48 1.31 0.46 0.8 -0.27 0.02 0.07 -1.16 1.1 0.44 2.93 0.02 4.33 1.63 4.14 0.49 3.86 0.11 0.18 -0.43 3.89 -0.42 4.53 -1.89 0 0.05 -0.22 1.36 -2.37 0.21 0.21 DLH -0.29 -0.13 -3.14 -0.47 -0.43 0 -0.37 -0.22 -0.08 0 -1.76 -2.67 -3.19 -3.98 0.37 -0.25 -0.41 -2.84 -0.5 -2.57 -6.29 -0.89 -1.15 -1.49 -5.69 -2.18 -3.04 -2.84 -0.54 -0.16 -1.19 0.32 -1.61 0.25 0.12 0.31 -5.06 -5.91 -3.33 -5.01 -1.17 -1.04 -1.49 -1.57 -0.41 -0.38 -0.33 0.3 -0.1 -1.16 -0.33 -3.41 -1.02 -0.62 0 -0.44 -1.05 -0.14 -3.8 -2.53 -2.23 -0.15 0.44 0.07 -0.31 -3.71 -0.87 -2.62 0.45 -0.32 -0.43 -3.74 -4.09 -2.19 -3.53 -1.04 -2.49 -2.02 -0.21 -0.71 -1.23 -0.79 -2.44 -1.1 -0.05 -2.35 0.24 -1.85 1.84 -1.75 0.97 -0.75 -2.39 -1.44 -0.05 0.53 0.44 0.1 -2.14 0.24 -1.53 -1.43 -0.64 -4.42 -2.79 -0.34 0.33 0.1 0 -2.4 0.92 -0.78 -1.37 -1.22 -3.22 -2.92 0.25 0.09 -2.83 -0.36 -2.79 -4.12 0.07 -0.54 -3.55 -1.37 -2.49 -1.52 -2.13 -2.86 -3.19 -0.8 -0.2 -4.41 -2.57 -2.85 -0.16 -5.24 -1.54 -5.78 -0.19 -0.5 -4.82 -0.1 -1.93 -3.87 -0.07 0.15 -3.72 -1.89 -0.16 -2.86 0.07 -0.39 -4.49 -3.74 -4.06 0.2 0.16 -1.84 0.28 -5.49 0.57 -1.27 -0.36 -0.74 -3.07 -0.5 0.55 -0.28 0.31 -0.13 0.13 -0.37 -0.21 0.1 -0.21 0.18 -3.95 -0.06 0.11 0.01 -3.75 -0.05 -0.19 -0.12 0.18 -4.17 -0.22 -0.22 dTDP -0.94 -0.79 -0.16 0.2 -0.04 3.72 -1.61 -1.09 -1.17 -0.09 1.48 -0.38 -0.48 -0.94 0.17 -0.48 -2.07 0.1 -0.52 3.01 1.44 -0.04 -0.64 -0.13 -0.3 -0.71 0.5 -0.28 -0.16 1 0.31 -0.35 0.2 -1.07 -0.3 -0.04 3.38 1.63 0.71 0.08 -0.16 0.39 -0.13 0.03 -1.52 -1.42 -1.59 -1.17 -0.89 0.17 -1.59 2.64 -1.01 -1.87 -0.29 -1.28 -0.55 -0.42 -0.05 2.42 -0.78 0.72 -0.36 0.09 -0.49 1.15 0.71 0.31 -1.02 -0.97 -1.15 4.38 -0.15 -0.62 0.01 -1 1.46 0.65 0.16 -0.46 -0.29 -0.4 -0.21 -0.22 -1.88 -0.1 -0.16 0.03 -0.69 -1.22 -0.24 0.41 0.27 0.8 0.4 -1.17 -0.02 0.25 0.71 -0.31 0.1 0.34 -0.34 0.2 2.74 -0.86 -0.21 0.05 -0.06 -0.45 0.06 -0.27 0.07 -0.36 1.17 -0.27 -0.23 -0.32 0.13 -0.31 2.59 2.41 0.06 0.33 2.62 0.23 0.65 0.19 -0.05 -0.3 2.29 0.3 -0.18 2.57 2.64 0.76 0.09 2.74 -0.22 0.2 -1.34 -1.53 2.82 0.12 0.3 2.23 0.38 -0.48 0 0.13 -0.17 -0.3 0.08 0.28 2.46 -0.48 -0.59 -1.52 0.02 -1.54 0.39 -0.21 0.45 0.28 -0.09 0.03 -0.72 0.24 0.15 -0.45 -0.08 -1.29 0.33 -1.08 -0.38 -1.77 -0.06 0.24 -0.66 -0.74 -0.67 -1.14 2.19 -0.03 -0.09 -1.75 0.39 2.22 0.16 0.16 dTMP -0.81 -0.61 0.47 0.78 -0.08 6.84 -2.79 -1.16 -1.06 -0.05 3.18 -0.24 -0.56 -0.71 0.39 -0.53 -1.66 -0.68 -0.37 4.45 3.19 -1.24 -0.44 0.17 0.57 -0.7 1.03 -0.61 -0.27 1.15 0.83 -0.33 1.8 -1.13 -0.28 -0.16 4.55 3.34 1.29 0.77 -0.22 0.6 0.01 0.02 -2.29 -1.12 -1.18 -0.85 -0.71 -0.1 -1.27 4.14 -1.19 -1.85 -0.44 -1.42 -0.34 -0.53 0.52 5.6 -0.67 0.48 -0.38 -0.01 -0.09 1.44 0.67 0.52 -0.93 -1 -1.72 5.59 -0.64 -0.66 -0.02 -0.76 3.66 1.27 0.12 -0.45 -0.48 -0.15 -0.26 -0.41 -1.69 -0.77 0.06 0.21 -0.65 -1.12 -0.03 0.57 0.9 0.82 0.53 -0.8 0.19 0.37 2.19 -0.33 0.01 0.43 -0.07 0.8 4.23 -0.68 -0.12 0.11 0.18 -0.37 0.01 0.37 0.6 -0.26 3.06 0.04 -0.11 -0.48 0.28 -0.2 4.01 4.02 0.17 0.44 4.49 0.73 1.06 -0.12 -0.26 -0.34 4.04 0.27 -0.4 3.8 4.83 0.82 0.04 4.46 -0.23 2.87 -1.09 -1.62 4.25 0.21 0.57 3.81 0.84 -0.89 0.1 0.12 0.12 0.16 0.09 0.19 3.73 -0.4 -0.76 -1.2 -0.07 -1.4 0.33 -0.16 1.29 -0.15 0.11 0.2 -0.59 0.59 0.03 -0.26 -0.1 -0.97 0.19 -0.89 -0.26 -1.45 -0.04 0.36 -0.49 -0.43 -0.47 -0.62 4.02 0.01 -0.04 -1.45 0.05 4.06 -0.05 -0.05 dTTP -0.97 -0.97 -0.44 -0.77 -0.46 -2.57 -3.44 -0.41 -0.13 0.98 0.85 -1.44 -0.2 -0.61 0.01 -0.16 -1.68 -0.7 -0.3 0.9 1.44 0.36 -0.83 -0.32 -0.09 -0.02 -1.24 -0.65 0.07 0.61 -0.19 -0.13 -0.43 -0.83 0.13 -0.26 1.85 1.45 -0.44 -1.08 -0.08 -0.23 -0.19 0 -1.32 -1.4 -2.06 -0.7 -1.15 -2.79 -1.43 0.67 -1 -0.19 -0.13 -0.98 -1.06 0.05 0.52 0.15 -0.33 0.29 -0.72 0.06 -0.89 1.16 1.9 -0.2 -1.16 -0.87 -1.16 4.19 0.03 -0.43 -1.29 -1.56 -0.24 -0.24 -0.21 -0.53 -0.14 -0.1 -0.4 -0.04 -1.34 -0.13 -0.43 0 -1 -1.09 -0.35 -0.26 -0.2 0.32 -0.31 -1.31 -0.27 0.08 -0.3 -0.53 -0.43 0.09 -0.34 -0.6 1.6 -1.12 -0.26 -0.19 -0.13 -0.57 -0.03 -0.29 0 -0.32 0.13 -0.11 -0.03 -0.11 -0.45 -0.1 1.59 1.25 0.07 -0.08 0.52 -0.77 0.13 0.09 -0.04 -0.46 1.28 -0.53 -0.35 0.13 0.63 -0.17 0.08 -0.02 -0.42 -1.09 -1.25 -1.56 1.03 0.25 -0.18 -1.51 0.02 -0.12 -0.4 -0.55 -0.43 -0.84 -0.17 0.1 0.57 -1.63 -1.33 -1.65 -0.02 -1.23 -0.59 -0.62 -0.51 -0.48 -0.28 -1.2 -0.54 -0.3 -0.42 -0.8 -0.05 -2.06 0.58 -1.77 -0.25 0 -0.3 0.01 -0.12 -0.19 -0.86 -1.13 0.78 -0.07 -0.38 -1.83 -0.18 1.74 -0.28 -0.28 dUMP -0.62 -0.76 2.61 0 0.09 4.59 0 -1.08 0.87 -0.09 -0.88 -1.83 -3.38 0.44 -0.3 -0.35 -3.76 -4.35 -0.38 -2.07 -5.08 -4.46 -3.36 0 -0.38 -0.13 -0.5 -3.97 0.12 -0.74 6.14 0.19 0.07 -2.06 -0.92 -2.47 -2.51 -3.29 -0.94 -0.45 0 -3.68 4.59 0 -1.82 -1.47 1.26 -2.69 -2.29 -4.99 1.98 -0.31 0 -0.86 -5.44 0 -1.65 -0.28 0 1.84 0.07 -0.62 -0.31 -0.93 6.04 0.14 0.21 2.34 -3.12 -0.83 1.04 -3.01 -0.46 0 -0.74 -0.23 0 1.9 -0.7 1.07 -0.66 2.73 -1.72 0 -0.24 -0.19 4.58 0.04 0 0 0.5 2.49 0.37 -0.35 0.83 3.89 5.07 0.06 -1.07 1.01 0.02 1.94 2.93 -0.35 0.56 -0.33 0.94 -0.4 2.18 2.07 1.56 2.24 0.57 0 -2.49 1.12 0.88 -0.22 -7.36 2.42 1.19 -1.5 0.84 0.78 -0.35 -0.11 -1.1 0 -0.62 -0.97 0.41 1.39 -0.08 -0.57 0.35 -0.87 -0.13 0.24 0.52 -2.36 -0.01 -6.37 0.88 -0.14 7.72 0.74 -1.42 -1.79 0.52 1.74 -1.04 4.82 1.03 0.12 -1.05 -0.03 -4.92 -2.7 1.3 -0.43 0.24 -1.87 1.4 -0.65 -0.27 -0.05 -0.72 3.28 0.01 0.66 -0.58 0.37 -1.83 -2.22 -0.94 0.88 -1.74 -0.24 -1.33 -1.47 9.44 -1.66 1.04 -0.64 0 13.67 5.69 -0.11 9.73 9.73 dUTP 0.03 0.27 0.99 1.03 -0.07 -4.15 0.45 -0.07 0.48 0.68 0.36 -0.15 0 0.95 0.74 -0.23 -0.58 -1.08 0.71 -2.61 0 0.23 -0.66 -0.47 -0.21 0.27 2.46 -0.75 0.14 -0.23 -0.12 -0.38 1.82 -0.29 -0.41 0.49 -0.91 0 1.95 -0.13 0.11 -0.53 -0.66 -0.07 -0.01 0.1 -0.16 0.11 -0.56 -1.26 -0.07 -1.67 0.09 0.67 -0.34 0.23 -0.37 0.11 -0.1 -0.5 -0.09 0.52 0.59 -0.38 -0.34 2.65 -0.05 -0.39 -0.14 -2.04 -0.77 0.36 0.08 0.09 1.07 -0.29 -1.32 -0.32 -0.15 -0.18 -0.08 -0.2 -0.18 -0.05 0.01 -0.42 -0.23 -0.1 0.02 0.02 0.61 -0.8 0.86 -0.43 -0.24 -0.29 -0.12 0 1.38 -0.39 -0.2 -0.73 -0.22 -0.22 -1.05 -0.42 -0.38 -0.24 0.27 -0.4 0.19 -0.24 0.05 -0.11 -1.01 0.04 -0.06 -1.72 0.05 -0.29 -0.92 -1.07 -0.24 -0.01 -1.76 -0.37 0.9 -0.29 0.82 -0.04 -2.04 -0.53 -0.56 -3.02 -0.13 -1.08 0.05 -0.84 -0.02 -1.59 1.3 -0.1 -1.28 0.44 -0.11 -1.15 -0.23 0.21 0.58 -0.7 0.29 0.11 0.21 0.34 -0.76 -0.31 0.34 0.18 0.5 0.92 0.58 -0.15 -0.38 -0.74 -0.26 0.33 0.89 0.42 -0.13 -0.14 0.22 -0.06 -1.6 0 -0.35 -0.35 0.26 -0.03 -1.24 0.35 0.15 0.24 -1.15 0.25 0.22 0.09 0.26 -0.87 0.13 0.13 FAD 0.08 0.09 -0.23 -0.17 0.15 -0.72 -0.16 0.31 0.1 -0.25 -0.67 0.06 -0.14 -0.12 0.1 0.03 -0.05 0.04 0.33 -1.38 -1.51 -0.49 0.14 0.2 -0.53 -0.24 0.93 -0.26 0.07 -0.06 0.03 0.01 -0.09 0.14 -0.08 0.01 -1.06 -1.62 0.77 -0.12 0.16 -0.08 -0.72 0.1 0.05 0.15 0.13 0.26 0.06 -0.5 0.08 -0.69 0.18 -0.49 -0.09 -0.01 -0.08 0.18 -0.45 -0.79 -0.37 0.25 0.13 -0.09 -0.03 0.68 0.57 -0.15 0.08 0.08 -0.12 -0.69 -0.43 0.35 0.28 -0.31 -0.57 0.19 0.05 0.33 -0.04 0.08 0.07 0.18 0.07 -0.32 0.35 0.04 0.43 0.32 0.1 -0.01 -0.16 -0.18 -0.11 0.21 -0.08 0.04 -0.25 -0.01 -0.17 -0.01 -0.04 -0.26 -1.2 0.16 0 0 0.04 -0.27 0.02 -0.46 -0.38 -0.12 -0.45 0.31 0.02 -0.05 -0.02 0.09 -1.2 -0.98 0.02 -0.1 -1.32 -0.32 0.03 -0.25 -0.01 0.05 -1.19 -0.09 -0.13 -1.43 -1.02 -0.59 -0.02 -0.85 -0.1 0.09 -0.02 0.14 -1.33 0.04 -0.04 -0.53 -0.01 0.05 0.29 0.19 0.08 0.27 -0.24 0.07 -1.18 -0.07 0.12 0.17 0.19 -0.07 0.91 0.45 0.19 -0.57 0 -0.01 0 -0.03 0.06 -0.13 0.09 0.15 -0.09 0.16 -0.12 -0.14 -0.02 0.08 0.44 0.69 -0.01 0.18 -1.3 0.03 -0.21 0.17 0.05 -1.48 0.03 0.03 FMN -0.02 -0.03 -0.09 -0.09 0 -0.82 -1 -0.23 -0.21 -0.07 0.79 0.06 -0.4 0.47 0.07 0.07 -0.65 -0.21 0.49 -0.38 0.05 0.19 -0.26 0.74 -0.4 -1.05 0.78 -0.63 0.03 0.16 0.09 0.18 0.01 0.01 0.07 0.42 0.13 -0.08 0.84 -0.02 0.52 -0.61 0.74 0.37 -0.45 -0.42 -0.57 -0.09 -0.15 -1.07 -0.45 0.45 0.09 -0.67 -0.46 -0.14 -0.34 0.17 -0.84 0.21 0.08 0.51 0.07 -0.04 -0.5 0.64 0.59 -0.18 -0.06 -0.11 -0.39 0.27 -0.71 0.65 0.27 -0.75 0.33 0.2 -0.17 0.42 0.08 0.18 0.13 0.3 -0.01 -0.2 0.59 0.22 0.12 0.41 0.07 -0.27 0.4 0.08 -0.16 -0.35 -0.52 0.2 0.01 0.28 -0.06 0.15 -0.12 -0.16 0.16 0.05 0.08 -0.3 0.01 -0.68 -1.19 -1.11 -0.36 -0.74 -0.22 0.22 0.06 0.18 -0.36 0.34 -0.29 -0.46 0.07 -0.23 0.34 -0.73 0.23 0.26 0.05 0.42 0 0.12 -0.04 -0.39 0.37 -0.55 0.12 0.37 -0.13 0.33 -0.44 -0.35 -0.35 0.06 0.11 0.43 0.44 0.46 0.35 0.21 0.02 0.35 -0.22 0.19 -0.14 -0.17 0.11 -0.33 0.08 0.21 0.73 0.1 0.15 -1.64 -0.05 0.04 0.88 0 -0.07 -0.22 0.25 -0.23 0.35 -0.15 -0.07 -0.55 0.42 0.11 0.46 0.31 -0.05 0.04 -0.24 0.09 -0.09 -0.21 -0.48 -0.23 -0.26 -0.26 fructose-1,6-bisphosphate 0.43 0.21 0.01 -0.07 -0.33 -4.63 -0.41 -0.17 0.01 0.06 -0.35 -0.31 -0.05 0.25 -0.33 -0.1 -0.1 -0.06 -0.1 -0.48 -0.37 -0.04 -0.87 -0.95 0.76 0.46 1.24 -0.17 -0.01 -0.63 -0.35 0.07 0.71 0.25 -0.25 -0.29 -0.3 -0.34 0.57 -0.74 -0.63 -0.2 -0.23 -0.18 -0.49 0.43 -0.25 0.09 0.14 -0.01 0.07 -1.42 -0.01 0.73 0.07 -0.38 0.05 0.2 0.13 -0.88 0.06 0.93 -0.3 -0.47 0 -0.11 0.55 0.11 -0.33 -0.01 -0.69 -1.29 -0.27 -0.1 0.23 1.04 -1.46 -0.59 -0.03 -0.46 -0.06 0.08 0.18 -0.22 0.52 -0.38 -0.36 -0.55 -0.13 -0.17 -0.12 -0.75 -0.34 -0.83 0.14 -0.12 0.59 -0.08 -0.55 -0.18 -0.36 -0.14 -0.53 0.15 0.12 -0.08 -0.73 0.22 -0.82 -0.75 0.7 -1.02 -0.38 -0.36 -0.11 -0.48 -0.08 0.01 0.08 -0.41 -0.21 -0.15 -0.62 0.19 -0.24 0.77 -0.4 -0.18 0.21 -0.09 -1.33 -1.17 -0.05 -1.7 -0.74 -0.75 -0.13 -0.98 0.51 -1.19 0.08 -0.29 -1.34 -0.19 0.24 -0.63 -0.29 0.18 0.7 -0.65 -0.28 -0.14 -0.61 0.84 -2.29 0.33 -0.39 -0.22 0.17 -0.05 0.74 -0.59 0.49 0.19 -0.69 0.22 -0.16 -0.51 -0.39 0.33 -0.24 0.61 0.24 -0.31 -0.36 -0.12 -0.26 -0.35 0.12 0.31 -0.34 0.27 -0.92 -0.02 0.05 -0.05 0.28 -0.65 0 0 fructose-6-phosphate 0.15 0.28 0 -0.15 0 -2.28 -0.12 0 0 0 -0.59 0.27 -0.05 0.18 -0.96 0.88 -0.02 0.18 -0.23 -0.23 0 -0.43 0.47 -1.75 1.74 1.79 0 -0.37 -0.42 0.1 0.42 0.23 0.17 0.87 -0.37 -0.09 -0.52 0 0 -0.34 -2.07 -0.7 -0.12 -0.46 -1.95 -0.14 0.02 -0.17 0.74 0.06 0.8 -1.01 -0.27 0.74 -0.14 -0.63 -1.17 -0.21 1.06 -0.28 -0.16 1.04 -0.88 -0.44 -2.26 0 0 -1.41 0.22 0.46 -0.67 0 -0.07 -0.72 -0.07 0.57 -2.42 -0.45 -0.27 -0.35 0.54 -0.01 -0.8 -1.98 -0.18 -0.05 -0.8 0.59 -0.08 -1.23 -0.29 1.81 -0.63 -0.26 -1.14 0.15 1.71 0 -0.22 -0.37 -0.37 0.02 -0.18 1.66 1.4 -0.01 0.24 -2.34 -0.3 1.52 1.44 -0.14 0 1.69 -1.75 0.07 0.16 0.72 -0.34 -0.11 1.09 -3.16 0.01 -0.44 -0.21 1.79 -0.5 -0.85 0 -0.36 0.9 -0.39 0.05 -1.66 -0.48 -0.39 -0.36 -1.3 -0.07 -0.91 0 0.43 0.07 -0.56 1.08 -1.23 -0.64 0.42 -0.44 1.06 -0.37 -0.38 -0.75 0.84 -1.19 0.6 0.08 1.14 -0.13 0.14 -0.03 0.3 0.11 0.16 -0.57 0.33 -0.26 1.63 0.19 0.61 0.07 0.18 0.97 -0.73 -0.03 -0.01 -0.5 0.23 0.2 0.41 -0.77 0.27 0 0 0 0 0.29 0 0.04 0.04 fumarate -0.11 0.44 -0.25 -0.13 -0.27 -0.54 -1.4 -0.04 0.1 0.12 0 -0.9 -0.58 -0.45 -0.13 2.68 -0.57 -1.05 -0.39 0.01 -0.14 0.52 2.59 -0.5 -0.41 -0.16 -0.4 -0.63 0.46 0.07 -0.46 0.29 -0.33 0.49 -0.31 -0.12 -0.38 -0.16 -1.19 -1.44 0.55 -0.86 -0.32 -0.13 0.25 0 0.76 0.47 0.2 -1.23 2.54 -0.22 -0.51 -0.21 -0.36 0.27 0.04 -0.27 -0.84 0.53 -0.3 0.18 0.7 -0.31 0.07 -0.27 -0.34 -0.46 -1.09 -0.23 -0.91 0.56 -0.36 0.15 -1 -0.22 0.05 -0.55 1.36 -0.26 -0.36 -0.45 -0.74 0.13 0.4 -0.21 -0.02 2.58 0.23 -0.42 -0.32 -0.84 0.17 -0.65 -0.49 0.69 -0.51 0.09 -0.17 -0.29 -0.16 0.06 -0.12 -0.33 0.1 -0.07 0.19 -0.67 0.22 -1.37 -0.09 4.68 -0.89 -0.37 -0.67 -0.83 -0.21 0.21 0.9 0.11 -0.19 -0.5 0.49 -0.05 0.19 -0.53 -0.59 0.22 -0.5 -0.16 0.13 0.12 -0.47 -0.41 0.39 -0.37 -0.2 0.12 0.03 -0.3 -0.39 0.25 0.37 -0.24 -0.61 0.2 0.15 0.14 0.08 -0.52 0.66 -1.44 -0.34 -0.07 -0.38 -1.11 -0.85 -0.11 -0.44 -0.16 0.27 -0.52 -0.11 -0.98 -0.49 -0.45 -0.37 -0.54 -0.05 -0.07 -0.11 0.02 1.08 -0.18 -0.27 -0.53 0.12 0.07 -1.47 0.7 -0.03 0.15 -0.36 -0.16 -0.06 0.06 0.34 0.06 0.11 0.11 G3P/DHAP -0.13 0.17 -0.27 -0.51 0.39 -2.91 -0.67 -0.34 -0.02 0.18 0.51 -0.63 0.13 0.15 1.41 -0.89 0.13 0.15 0.88 0.3 -0.12 0.15 -1.07 -1.39 0.68 1.37 1.14 -0.25 0.3 -0.59 -0.62 0.9 -1.05 1.64 -0.31 1.23 -0.06 -0.26 0.79 -1.88 -1.22 -0.02 0.47 -0.15 0.17 -0.21 -0.65 -0.15 -0.11 0.23 -0.4 -0.28 0.38 1.4 -0.26 0.14 0.22 0.29 -0.52 -0.15 0.44 0.07 1.32 -1.04 0.25 0.98 1.07 0.98 -0.82 0.88 -0.76 -0.2 0.41 -0.11 -1.4 0.81 -1.48 -0.6 -0.19 -0.89 -0.65 1.54 0.4 -1.34 1.1 -0.39 -0.83 -0.54 -0.24 -0.3 0.29 -0.32 0.99 -1.44 0.5 -0.27 0.15 0.2 -0.43 0.08 -0.22 -0.2 -0.51 1.33 0.52 -1 -1.3 1 -1.29 -0.25 0.89 -1.14 -0.25 0.64 0.63 -0.25 -0.47 0.02 -0.06 -0.51 0.74 0.23 -0.97 0.96 -0.1 1.05 0.2 -0.33 -0.17 2.11 0.13 -1.22 -1.78 -2.14 -0.74 -0.62 1.06 -0.27 0.93 -1.09 -0.18 -0.54 -0.86 1.44 -0.46 0.48 -0.49 1.65 0.59 -0.38 1.81 -0.3 -0.9 0.37 -1.7 0.93 0.34 0 -1.13 0.93 0.65 -0.58 0.71 0.11 -0.34 -0.73 0.69 -0.52 -0.56 0.39 1.39 0.76 1.58 -0.49 -0.29 0.12 1.28 -0.69 0.27 0.17 -0.27 -0.17 0.07 0.04 0.47 0.04 0.31 0.24 -0.2 -0.2 GDP -0.26 0.18 -0.33 0.24 -0.16 -1.34 0.48 0.41 0.37 0.29 -1.25 -0.33 -0.32 -0.56 -0.05 -0.48 -0.29 -0.75 -0.5 -2.44 -1.99 -0.11 -0.54 -0.84 -1.39 -1.18 0.14 -0.5 -0.06 0.85 0.31 -0.15 0.04 -0.02 -0.29 -0.04 -1.21 -1.57 0.11 0.11 -0.28 0.27 -0.27 -0.1 -0.29 -0.22 0.06 0.45 0.45 -0.27 -0.13 -1.46 0.01 -2.02 -0.24 0.14 0.27 -0.29 -0.57 -1.86 -0.96 0.67 0.27 0.19 0.18 0.76 0.41 0.13 0.18 0.12 0.1 0.01 -0.23 -0.57 -0.42 -0.33 -1.99 0.26 -0.09 -0.49 -0.34 -0.39 -0.29 -0.25 -0.7 -0.59 -0.36 -0.1 0.27 0.1 -0.11 0.45 0 0.71 0.24 -0.03 -0.04 0.24 0.27 -0.78 -0.07 0.17 -0.07 -0.17 -1.86 0.16 0.06 -0.01 0.06 -0.21 -0.05 -1.17 -0.04 -0.57 -1.38 -0.2 -0.2 0.01 -0.12 -0.33 -1.94 -1.09 -0.03 0.23 -1.53 -0.18 0.49 -0.14 -0.31 -0.3 -1.67 0.03 -0.34 -1.57 -1.85 -0.79 -0.05 -1.26 -0.19 -1.63 0.29 0.07 -1.9 0.19 0.09 -0.97 -0.72 -0.52 0.28 0.1 0.25 -0.67 0.43 0.18 -1.82 -0.55 -1.21 0.29 -0.58 -0.35 0.34 0.27 0.58 -0.71 -0.2 -0.12 -0.38 0.3 0.04 -0.04 -0.2 0.19 -0.23 0.41 -0.1 -0.55 -0.21 0.16 -0.46 1.45 0.01 -0.36 -2.17 -0.11 -0.1 -0.15 0.01 -1.99 0.23 0.23 glucose-1/6-phosphate 0.18 0.23 -0.23 -0.73 -0.26 -1.41 -0.5 0.14 0.32 0.13 -0.64 -0.01 -0.09 0.29 -0.46 0.06 0.6 0.47 0 -0.12 -1.43 0.05 -0.22 -0.29 -0.39 -0.57 3.52 -0.31 -0.19 0.36 -0.07 -0.12 -0.36 0.32 -0.53 0.21 -0.55 -1.37 2.35 -0.68 -0.07 -0.13 0.1 0.26 0.05 0.51 -0.09 0.07 -0.04 0.92 -0.09 -1.01 -0.05 -0.51 -0.08 0.13 -0.47 -0.07 -0.16 -0.9 0.32 0.66 -0.14 -0.07 -0.37 2.35 1.04 -0.25 0.21 -0.26 -0.84 -0.44 -0.18 -0.02 0.24 -0.35 -1.08 -0.31 0.56 -0.52 -0.26 0.22 -0.19 0.16 0.22 0.05 -0.41 -0.2 0.4 0.01 -0.03 -0.28 0.03 -0.13 -0.27 -0.23 -0.03 -0.04 -0.01 -0.16 -0.1 -0.47 -0.11 -0.41 -0.79 0.02 -0.37 -0.18 -0.1 -0.54 0.07 -0.38 -0.1 -0.2 -1.4 -0.02 0.02 0.08 0.32 -0.04 -0.79 -1.22 -0.3 -0.03 -0.7 0 0.35 0.41 0.21 0.27 -1.25 -0.77 -0.02 -1.32 -0.9 -0.64 -0.04 -0.75 -0.19 -1.91 0.22 -0.21 -0.92 -0.49 -0.24 -0.75 0.19 0.27 -0.23 -0.01 -0.11 -0.07 -0.62 -0.15 -1.22 -0.07 -0.72 0.04 0.04 0.26 0.15 -0.31 -0.06 0.9 -0.29 0.01 0.11 -0.21 -0.17 -0.06 0.17 0.08 0.2 -0.33 0.03 -0.26 0.23 -0.14 0.15 0.52 -0.75 0.2 -0.7 0.38 -0.34 -0.29 0.2 -1.03 -0.02 -0.02 glutathione disulfide 0.25 0.07 -0.21 -0.36 0.08 -0.59 -0.41 0.01 -0.04 0.11 -0.51 0.08 -0.1 -0.49 0.08 -0.17 0.1 -0.3 -0.37 -0.25 -0.5 -0.01 -0.36 -0.39 -0.41 0.13 0.72 -0.24 0.01 0.12 -0.28 0.01 -0.57 -0.09 -0.2 -0.51 -0.19 -0.45 0.49 -0.23 -0.54 -0.46 -0.8 -0.15 -0.5 0.08 0.03 0.02 -0.08 -0.01 -0.19 -0.03 -0.03 -0.55 -0.2 -0.29 -0.14 -0.03 0.67 -0.39 -0.22 0.44 0.25 -0.55 -0.05 0.54 0.46 -0.3 -0.24 0.19 -0.27 0.26 -0.27 -0.31 0.17 0.26 -0.68 -0.5 0.08 -0.54 -0.52 -0.3 -0.26 -0.39 -0.07 0.18 -0.68 -0.42 -0.04 -0.24 -0.28 -0.18 -0.69 -0.25 -0.16 -0.02 0.36 0.13 -0.14 -0.2 -0.48 -0.28 -0.24 0.01 -0.07 -0.02 -0.11 0.05 -0.24 -0.7 0.23 -0.43 -0.1 0.48 -0.35 -0.32 -0.43 -0.06 -0.05 -0.09 0.21 -0.31 -0.05 -0.03 -0.46 0.82 0.05 -0.2 -0.15 -0.46 -0.12 -0.51 -0.15 -0.53 -0.52 -0.26 -0.03 -0.34 -0.21 -1.11 -0.04 0.14 -0.24 0.13 -0.23 -0.09 -0.07 -0.06 -0.17 -0.15 0.21 -0.23 -0.42 0.3 -0.6 -0.23 -0.25 0.01 0.05 -0.52 0.27 -0.44 0.05 0 -0.19 0.09 -0.65 -0.46 -0.2 -0.09 -0.25 0.1 -0.07 -0.08 -0.31 -0.18 -0.24 -0.17 0.02 0.64 -0.02 0.28 -0.34 0.14 0 0.03 0.33 -0.19 0.14 0.14 glycerate -0.07 0.11 0.37 -0.47 0.17 -0.34 -0.56 0.14 0.43 0.47 0.43 -0.09 -0.28 0.42 0.17 -1.12 -1.32 -1.54 -0.17 -1.92 -0.48 -0.4 -1.57 0.07 0.31 2.56 0.84 -0.28 -0.09 -0.41 0.01 -0.29 -1.24 -0.6 -0.5 0.26 -0.81 -0.83 0.51 -0.54 0.17 -0.2 0.08 0.18 0.28 -0.09 0.7 -0.1 -0.46 -2.31 -1.23 -1.43 0.15 3.45 -0.03 0.29 -0.01 0.16 -0.57 -0.57 -0.13 0.33 -0.02 0.03 -0.25 0.68 0.43 -0.19 -1.25 -0.67 -1.01 -0.21 -0.14 0.4 -0.36 -0.2 -0.56 -0.06 -0.2 0.06 -1.22 -0.23 -0.14 0.28 0.75 -0.42 0.21 -0.68 0.13 0.29 0.7 -0.32 1.58 -0.24 0.03 -0.43 -1.13 0.24 -0.66 -0.35 0.29 -0.06 0.06 0.15 -0.87 0.15 -0.14 -0.12 0.3 -0.6 -0.31 -0.26 0.56 -0.03 -0.69 -0.21 -1.22 -0.02 0.28 0.17 -0.73 -1.02 0.32 0.12 -0.77 -1.19 -0.71 0.36 -0.29 0.39 -0.71 0.09 -0.44 -0.96 -0.1 -0.22 0.48 -0.06 0.09 0.29 0.08 0.14 0.37 -0.4 0.06 -0.4 -0.26 -0.47 -1.12 -0.49 0 -0.19 -0.5 0.29 -1.21 -0.48 -1.03 -0.15 -0.36 0.59 0.79 -0.06 -0.06 -2.75 0.22 -0.33 0.88 -0.42 -0.03 -0.34 -0.49 0.25 -0.07 0.14 -0.12 -0.11 -0.28 -0.26 -0.31 -0.06 -0.15 0.13 -0.62 0.12 0.52 0.24 -0.18 -0.06 -0.16 -0.16 GMP -0.05 0.25 0 -0.51 0.09 -3.3 0.16 0.44 0.37 -0.08 -1.55 -0.74 -1.03 -0.47 -0.14 -0.3 -0.5 -0.83 -0.88 -2.83 -1.85 -0.98 -0.95 -0.85 -0.66 -1.28 0.56 -0.6 -0.4 -0.26 0.04 0.42 0.05 0.28 -0.36 -0.34 -2.56 -1.88 -0.14 -0.33 -0.3 -0.27 -0.48 -0.18 -0.23 -0.03 -0.07 -0.15 0.13 -1.55 -0.03 -2.33 0.31 -0.73 -0.33 0.07 -0.85 0.08 -1.6 -2.45 -0.57 -0.65 0.04 -0.37 -1 -0.5 0.12 0 0.03 0.26 0.2 -3.05 -0.66 -0.58 -0.11 0.22 -0.88 -0.38 0.11 -0.57 0.08 -0.04 -1.77 -0.37 1.68 -0.42 -0.75 -0.06 0.45 0.29 -0.28 0.29 -0.09 0.01 -0.79 -0.01 0.04 0.34 1.14 -0.88 0.04 -0.02 0.32 -0.16 -1.64 0.48 0.99 -0.49 0.48 0.62 -0.14 -1.49 0.41 -0.84 -1.96 -0.16 -0.12 0.25 -0.53 -0.21 -1.69 -2.09 1.28 0.08 -1.79 0.37 0.67 -0.26 -0.28 -0.52 -1.91 -0.37 0.19 -2.28 -2.6 -0.92 -0.23 -2.95 -0.03 -2.27 0.47 -0.38 -2.54 -0.12 0.24 -2.37 -0.1 -0.57 0.3 -0.49 -0.06 -0.5 -0.66 -0.76 -2.87 -0.87 -0.92 0.71 1.09 -0.55 -0.02 -0.81 1.03 -0.38 -0.51 -0.16 -0.92 0.25 0.28 0.17 -0.11 0.68 0.16 -0.19 -0.35 1.06 -0.19 -0.21 -0.75 2.32 -0.25 0.67 -2.1 -0.16 -0.03 -0.02 0.17 -1.98 0.07 0.07 GTP -1.45 0.11 -0.66 -0.03 -0.57 -7.55 -1.06 4.27 7.27 8.14 -1.45 -3.15 0.35 -0.22 1.24 -0.07 -1.05 -0.07 -0.32 -1.75 -2.07 0.65 -0.68 -0.42 -0.58 -0.42 -2.88 -0.69 1.19 -0.27 0.11 0.25 -0.07 1.62 0.7 -0.17 -2.22 -1.83 -0.3 -0.8 0 -0.25 -0.22 0.1 0.46 -0.14 -0.69 0.02 0.94 -2.07 0.13 -3.7 0.21 -0.64 -0.43 0.52 -0.05 0.14 -0.65 -4.63 -0.28 0.1 0.7 0.34 -0.15 -0.01 -0.22 -0.22 0.38 0.23 -0.05 0.34 0.34 -0.16 -1.42 -0.21 -2.07 -0.26 -0.33 -0.24 0.06 0.84 -0.32 0.13 0.21 -0.48 -0.37 0.11 0.25 0.31 -0.74 -0.23 -0.48 0.43 -0.25 0.61 -0.13 0.03 -1.06 -0.23 -0.26 1.55 -0.13 -0.89 -3.83 -0.28 -0.12 -0.21 -0.09 -0.24 0.08 -1.2 0 -0.15 -1.25 -0.13 0.11 0.26 -0.34 -0.08 -3.74 -1.67 -0.01 -0.15 -1.76 -0.6 -2.79 -0.02 0.02 -0.27 -2.04 -0.49 -0.92 -2.84 -3.59 -1.14 0.48 0.15 0.31 -1.88 0.23 -0.34 -3.06 0.94 0.01 -0.21 0.14 -0.05 2.2 -0.35 0.76 -1.31 0.02 0.1 -1.68 -1.42 -0.79 0.42 -1.81 -0.06 -0.2 -0.28 0.81 -0.32 -0.33 -1.09 -0.24 0.16 -0.48 -1.06 0.61 1.03 2.54 -0.18 -0.13 0.22 1.16 0.56 -1.46 0.18 1.14 -1.25 0 -0.33 3.38 3.29 -0.68 5.08 -0.36 -0.36 guanine 0.25 0.3 0.3 0.17 -0.15 1.32 -0.09 0.47 0.39 0.02 0.25 -0.44 -0.7 -0.38 0.67 -0.02 0.26 -0.42 0.77 0.06 0.73 -0.42 -0.24 -0.04 -0.16 -0.52 -0.11 -0.48 0.45 0.28 0.08 -0.28 -0.27 -0.1 -0.21 0.42 0.13 0.51 0.1 0.3 0.79 0.23 0.1 0.41 0.6 0.24 0.31 -0.05 0.19 -0.24 0.1 -0.38 0.55 -0.75 0.26 0.48 0.19 0.37 -0.8 0.43 0.17 -0.08 0.53 0.52 0.07 0.57 0.45 0 -0.55 0.07 -0.41 1.13 -0.85 0.07 0.28 -0.06 0.45 0.3 0 -0.12 -1.03 0.39 -0.21 0.58 0.46 -0.81 -0.29 0.24 0.85 0.75 0.57 0.43 0.75 0.22 0.04 0.19 -0.28 0.05 0.26 -0.08 0.49 0.77 0.39 -0.09 0.18 0.52 -0.31 -0.11 -0.25 -0.23 0.06 -0.91 0.42 -0.53 0.28 0.22 -0.75 0.04 0.6 0.34 0.07 0.3 0.01 -0.14 0.28 -0.19 -0.12 0.51 -0.18 0.07 -0.27 -0.48 -0.15 -0.37 0.47 -0.27 0.36 0.49 0.2 -0.69 0.25 0.44 -0.1 0.41 0.54 0.12 0.52 -0.14 0.47 0.11 0.24 -0.11 -0.37 -0.16 -0.16 -0.36 -0.33 0.56 -0.39 0.14 1.22 -0.33 0 -0.19 -0.06 -0.17 -0.11 0.35 -0.13 -0.15 0.32 0.72 -0.43 0.01 -0.38 -0.13 0.16 0.27 -0.29 0.66 0.32 0.27 0.09 -0.17 0.14 0.01 0.33 0.27 0.39 0.39 guanosine 0.37 0.61 -0.75 0.13 0 -1.79 0.26 0 -0.03 -1.07 0.95 -0.65 -1.29 0.01 0.57 0.14 -0.59 -8.77 1.47 -2.12 1.46 -0.93 -0.05 -0.47 -1.25 -0.36 -0.42 -1.15 0.25 0.04 -0.23 -0.14 -1.74 0.61 -0.14 0.87 0.04 1.21 -0.94 -0.03 0.5 -0.23 0.22 0.28 0.73 0.41 0.24 -0.14 0.28 -1.1 0.13 0.03 0.65 -0.47 -0.08 0.58 0.48 0.06 -1.02 0.38 0.28 -0.44 0.64 0.22 0.11 -1.29 0.39 0.26 -1.52 0.37 -0.41 0.96 -0.83 -0.23 0.46 -0.25 -0.1 -0.15 -0.12 -0.44 -2.16 0.52 -0.41 0.25 0.79 -0.88 -0.58 0.32 0.44 0.72 0.48 0.39 1.26 0.11 0.19 0.24 -1.21 0.11 -0.15 -0.41 0.14 1.4 0.52 -0.37 0.34 0.74 -0.21 0.19 0.07 -0.22 -0.38 -0.1 -0.57 -1.33 0.05 0.33 -1.99 0.16 0.57 0.36 0.1 0.83 0.25 0.15 0.08 -0.84 -0.22 0.58 0.18 -0.28 -0.03 -0.82 -0.39 -0.04 0.41 -0.69 0.31 0.7 0.35 -1.11 0.78 0.65 -0.29 0.3 1.78 0.47 0.09 -0.13 0.33 -0.25 0.33 -0.17 -0.44 -0.33 0.12 -0.59 0.44 0.92 -0.1 1.5 1.16 -0.58 0.09 -12.12 -0.19 -0.36 0.14 0.33 -0.25 -0.17 0.25 0.87 -0.31 0.23 -0.52 -0.22 -0.03 -0.1 -0.24 0.82 0.13 0.32 -0.85 -1.56 -0.83 -0.91 0.64 -1.83 0.4 0.4 hypoxanthine -0.47 0.08 0.37 0.23 0.31 0.35 -0.4 0.16 0.29 0.19 0.64 -0.4 -0.27 0.21 0.43 -0.03 -0.12 -0.12 -0.03 -0.07 0.37 -0.23 -0.25 0.76 -0.02 -0.13 0.25 -0.07 0.33 -0.21 0.03 -0.14 0.37 -0.8 0.05 0.49 -0.07 0.1 0.19 -0.22 0.86 0.07 0.34 0.42 0.76 0.09 -0.05 -0.21 -0.23 -0.4 0.05 -0.31 0.37 0.31 0.06 0.49 -0.32 0.4 -0.36 0.51 0.04 -0.13 0.66 0.36 -0.38 0.4 0.27 -0.4 0 -0.7 -0.34 0.84 -0.2 0.65 -0.82 -0.57 1.04 0.13 -0.07 0.1 -0.01 0.24 -0.19 0.85 1.05 -0.31 0.25 0.4 0.5 0.61 0.38 -0.31 0.76 0.02 -0.38 -0.18 -0.43 -0.08 -0.23 0.29 0.91 -0.2 0.08 -0.11 -0.22 0.15 -0.13 -0.5 0.32 -0.5 -0.42 -0.36 0.3 -0.34 -0.13 -0.17 0.27 -0.25 -0.04 0.3 -0.17 -0.37 0.25 -0.29 0.23 -0.56 -0.68 0.56 -0.51 0.6 -0.43 0.29 -0.4 -0.47 0.7 0.18 0.35 0.71 -0.12 0.17 -0.11 -0.01 -0.39 0.48 0.17 0.21 0.55 0.07 0.31 0.15 0.26 -0.19 0.15 -0.29 -0.05 -0.72 -0.16 -0.03 -0.47 0.7 0.64 0.12 -0.33 -0.55 0.31 -0.46 0.76 -0.06 0.06 -0.44 0.2 0.06 -0.67 0.17 0.09 -0.39 0.39 0.21 -0.26 0.09 0.23 -0.21 0.28 0.14 0.14 -0.09 -0.15 0.31 0.07 0.07 IMP 0.39 0.44 0.12 -0.2 -0.09 -1.23 -0.36 -0.01 0.28 0.02 0.02 -0.53 -0.34 -0.26 0.16 0 0.31 -0.43 -0.31 0.24 -0.05 -0.47 0 -0.21 -0.62 -0.37 0.78 -0.37 0.08 0.36 -0.1 -0.07 -0.05 0.61 -0.18 -0.14 0.75 -0.08 0.82 -0.27 0.11 -0.07 -0.22 0.14 -0.17 -0.05 0.14 -0.21 0.58 0.25 0.93 0.4 0.09 -0.61 -0.27 0.11 0.08 -0.2 -0.38 0.02 -0.19 0.37 0.22 -0.03 -0.04 0.49 0.44 -0.36 -0.05 0.15 -0.25 0.24 -0.23 -0.23 0.12 -0.49 0.02 0.24 0.22 -0.13 -0.34 0.47 -0.3 0.12 0.34 -0.26 -0.09 0 0.16 0.61 0.12 -0.03 -0.29 0.15 0.13 -0.28 -0.46 -0.03 0.82 -0.1 0.04 0.19 -0.2 -0.27 0.1 0.49 -0.52 -0.06 -0.2 0.39 -0.09 0.26 0 -0.43 -0.26 0.07 -0.18 0.21 0.36 -0.04 0.02 0.42 -0.51 0.21 0.29 -0.51 0.7 -0.3 -0.3 -0.22 -0.01 -0.3 -0.27 -0.16 -0.02 -0.32 -0.08 1.06 0.05 -0.57 -0.22 0.35 -0.52 0.2 -0.19 0.81 -0.07 0.42 0.46 -0.32 0.31 -0.02 -0.33 0.38 -0.05 -0.56 -0.5 1.44 -0.36 -0.26 0.76 0.04 0.16 0.2 0.21 0.3 -0.27 -0.01 -0.16 0.12 -0.03 1.03 -0.12 0.98 -0.25 -0.15 0.41 0.12 -0.07 0.16 -0.13 0.6 0.28 0.11 -0.03 -0.06 0.03 0.27 0 0 indole -0.35 0.05 -0.02 0.02 0.15 0.1 -0.86 0.3 0.05 0.02 0.34 -0.61 -0.31 -0.13 0.15 0.07 -0.22 -0.47 0.24 -0.44 0.37 -0.25 -0.23 0.16 -0.06 -0.12 -0.24 -0.24 -0.06 -0.1 -0.09 -0.02 0.02 -0.45 -0.05 0.31 -0.31 0.18 -0.26 -0.06 0.37 -0.11 0.17 0.19 0.55 0.09 -0.13 -0.3 -0.03 -0.86 0.08 -0.47 0.17 0.08 0.04 0.29 -0.11 0.32 -0.38 0.11 -0.02 -0.06 0.25 0.24 0.07 -0.01 -0.02 -0.22 0.03 -0.31 -0.18 0.14 -0.33 0.17 -0.69 -0.46 0.25 -0.06 -0.1 0.07 -0.1 -0.02 -0.2 0.29 0.58 -0.45 0.26 0.22 0.19 0.24 0.31 0.05 0.38 -0.3 -0.29 -0.12 -0.39 0.15 -0.03 -0.08 0.39 -0.3 -0.06 -0.08 -0.14 0.03 -0.05 -0.18 0.21 -0.33 -0.3 -0.61 0.05 -0.27 -0.24 -0.28 0.17 -0.21 -0.04 0.21 -0.17 -0.5 0.2 -0.32 -0.3 -0.53 -0.01 0.17 -0.41 0.28 -0.47 0.17 -0.42 -0.63 0.2 -0.01 -0.87 0.35 0.04 -0.05 -0.02 0.04 -0.33 -0.4 0.11 -0.03 -0.03 -0.14 0.05 0.04 0.11 -0.34 0.26 -0.19 -0.24 -0.73 -0.25 0.08 -0.38 0.2 0.43 0.05 -0.05 -0.72 0.27 -0.5 0.3 0.04 -0.14 -0.44 -0.03 0.17 -0.51 0.02 0.15 -0.3 0 -0.21 -0.41 0.04 0.12 -0.18 -0.14 -0.1 -0.03 0.03 -0.02 0.2 0.05 0.05 inosine 0.05 0.15 -0.01 0.09 0.07 0 -0.18 0.12 -0.07 -0.27 0.54 -0.08 -0.52 0.08 0.01 0.05 -0.27 -0.99 -0.56 -0.59 0.56 -0.29 -0.14 0.25 -0.45 0.43 0.41 -0.32 0.23 -0.01 0 -0.27 -0.54 -0.49 -0.38 0.09 0.06 0.26 0.37 -0.65 0.29 -0.29 -0.3 0 -0.02 -0.16 -0.08 -0.24 -0.35 -0.74 -0.18 0.1 0.28 0.64 -0.36 0.12 -0.35 0.34 0.03 0.28 0 -0.04 0.34 -0.2 -0.71 -0.34 0.3 -0.47 -0.4 -0.44 -0.65 -0.47 -0.24 0.34 -0.42 -0.45 0.38 -0.51 -0.05 -0.3 -0.6 0.26 -0.55 0.11 0.82 -0.37 -0.19 0.18 -0.13 0.32 -0.15 -0.25 0.52 0.02 -0.46 -0.47 -0.98 -0.04 0.04 0.11 0.52 -0.61 -0.24 -0.33 -0.05 0.09 -0.13 -0.66 0.32 0.03 -0.27 0.09 0.09 -0.61 -0.58 -0.24 -0.39 -0.25 0.01 0.07 0.1 -0.41 0.21 -0.39 0.27 -0.53 -0.25 0.48 -0.24 0.13 0.55 -0.11 -0.39 0.04 0.39 -0.05 0 0.62 -0.04 -0.11 -0.03 0.26 -0.04 0.11 -1.14 0.44 0.53 0.16 -0.42 0.08 0.03 -0.16 -0.11 -0.04 0.17 -0.32 -0.05 0.44 -0.1 0.41 0.27 -0.23 -0.25 -0.8 0.24 -0.12 0.33 0.09 0.04 -0.16 0.14 0.15 -0.54 0.14 -0.29 -0.34 0.51 0.01 -0.21 0.46 0.09 0.04 0.18 -0.26 -0.19 -0.17 0 -0.06 0 0 lactate -0.01 0.02 0.25 0.26 -0.18 -3.61 -0.81 -0.06 -0.05 0 -0.36 -0.08 -0.51 -0.34 0.07 -0.09 -0.53 -0.91 -0.26 -1.8 -0.6 -0.41 -0.39 -0.01 -1 -0.56 1.53 -0.37 0.05 -0.26 -0.05 -0.04 -0.89 -0.16 0.05 0 -1.01 -0.78 1.34 -0.24 0.44 -0.45 -0.15 0.23 0.09 -0.02 -0.35 -0.56 -0.18 -1.06 -0.14 -1.16 0.22 0.31 -0.32 -0.01 -0.43 0.53 -0.83 -1.15 -0.05 -0.5 -0.1 -0.2 -0.58 1.98 0.8 -0.55 -0.88 -0.65 -0.39 -0.7 -0.46 0.18 -0.18 -0.08 -0.67 -0.34 -0.37 -0.11 -1.01 -0.27 -0.49 0.35 0.42 -0.7 -0.05 0.12 0.14 0.22 0.18 -0.22 -0.08 0.02 -0.28 -0.49 -0.49 0.06 -0.39 -0.53 0.32 -0.12 -0.05 -0.17 -1.46 -0.15 -0.13 -0.46 0.1 -0.42 -0.19 -0.33 0.11 -0.51 -0.93 -0.3 -0.68 -0.1 -0.38 0.09 -1.77 -1.47 0.11 -0.18 -2.36 -0.4 -0.6 0.43 -0.34 -0.09 -0.88 0 -0.19 -1.18 -1.29 -0.55 -0.42 -0.78 -0.13 -0.45 -0.04 -0.12 -1.4 0.09 -0.18 -0.59 -0.16 -0.1 0.05 -0.06 0.03 -0.27 -0.19 -0.21 -1.12 -0.17 -0.35 0 -0.36 -0.27 0.38 -0.2 -0.04 -1.25 0.06 -0.21 -0.23 -0.06 -0.08 -0.11 -0.39 -0.01 -0.35 -0.01 -0.13 -0.36 -0.25 -0.17 -0.25 0.21 -0.07 -0.07 -0.69 0.16 -0.44 -0.02 0.82 -0.79 0.42 0.42 LD -0.16 -0.06 -0.38 -0.02 -0.19 -0.62 -0.28 0.08 0.11 0.11 -0.47 -0.26 -3.83 -1.02 0.53 0.12 -0.17 -0.33 1.08 -0.49 -1.42 -3.11 -0.91 -1.53 -0.03 -0.28 -0.38 -3.04 0.1 -0.07 0.08 0.03 0.28 0.3 -0.02 0.62 -4.25 -1.66 -0.48 1.41 0.41 -0.37 -0.11 -0.13 -0.54 0.6 1.14 0.08 0.31 -0.42 -0.03 -0.46 -1.21 -0.97 0.27 -0.9 -0.99 -0.48 -0.45 -0.18 0.22 0.89 0.01 0.38 0.09 -0.31 0.13 -2.28 0.53 -0.02 -0.17 0.36 -4.27 -2.7 0.46 -0.5 -2.38 -1.41 0.77 0.27 -0.02 0.71 -1.87 -0.57 -1.21 -3 0.16 -0.51 2.07 -2.16 0.16 -0.24 0.72 -0.05 0.26 1.15 -0.4 0.04 0.65 0.3 -0.02 -0.09 -0.07 -0.32 -0.34 0.27 -0.57 0.3 -0.49 -1.08 -0.38 0.06 -0.43 -0.38 -2.11 0.26 0.49 0.08 1.09 -0.29 -0.24 -3.21 -0.57 -0.63 -0.36 -0.52 0.1 -2.59 -1 -0.2 -1.14 -0.67 -0.29 -1.01 -0.11 -2.91 0.21 -3.82 0.13 -2.51 -0.29 0.24 0.41 0.17 0.13 -3.66 0.06 0.3 -1.07 -0.54 0.13 -0.15 -0.01 0.76 -0.81 -0.67 -0.17 -0.03 -0.69 -0.84 0.86 -4.26 0.12 -0.41 -0.36 0.08 -0.64 0.15 0.19 0.03 0.33 -0.28 -0.01 -0.07 -0.02 -0.92 0.35 0.26 -0.73 -0.49 0.05 0.29 -0.83 0.06 0.1 0.11 -0.08 -1.04 0.02 0.02 malate -0.02 0.43 -0.25 -0.18 -0.25 0 -1.55 -0.04 0.05 -0.01 -0.03 -0.91 -0.58 -0.52 -0.1 1.58 -0.45 -1 -0.41 0.46 -0.17 0.46 1.54 -0.41 -0.42 -0.22 1.77 -0.6 0.4 0.08 -0.51 0.29 -0.27 0.44 -0.32 -0.16 -0.21 -0.17 1.26 -0.4 0.44 -0.88 -0.4 -0.08 0.19 0.13 -0.54 0.47 0.17 -1.32 1.66 -0.27 -0.38 -0.08 -0.36 0.19 -0.22 -0.35 -0.88 0.52 -0.42 0.36 0.59 -0.35 -0.12 0.63 0.7 -0.49 -1.15 -0.24 -0.91 1.32 -0.43 0.04 -1.09 -0.26 0.08 -0.57 0.09 -0.29 -0.4 -0.49 -0.66 0.01 -0.37 -0.18 -0.07 1.57 0.31 -0.35 -0.3 -0.78 0.12 -0.57 -0.41 0.7 -0.55 0.06 0.08 -0.23 0.11 0.12 -0.14 -0.36 0.08 -0.09 0.09 -0.6 0.01 -1.3 -0.11 0.16 -0.79 -0.42 -0.64 -0.81 -0.33 0.17 -0.31 0.27 -0.23 -0.45 0.48 -0.04 0.16 -0.58 -0.56 0.21 -0.51 -0.22 0.09 0.03 -0.43 -0.38 0.38 -0.39 -0.17 -0.03 -0.05 -0.41 -0.38 -1.18 -0.56 -0.23 -0.66 0.1 0.12 0.14 -0.03 -0.45 0.52 -1.02 -0.29 0.03 -0.55 -1.16 -1.37 -0.26 -0.6 -0.13 0.22 -0.57 -0.1 -0.64 -0.48 -0.37 -0.43 -0.53 -0.07 -0.03 -0.1 -0.05 1.05 -0.19 -0.29 -0.62 0.14 0.11 -1.39 0.7 -0.03 0.24 -0.3 -0.14 -0.14 0.02 0.56 0.16 0.06 0.06 myo-inositol 0.25 0.21 0.47 0.47 0.06 -7.46 -1.33 -0.37 0.13 0.3 -1.03 0.14 -0.41 -0.63 -0.59 -0.31 -0.78 -1.42 -0.26 -3.18 -0.99 -0.33 -0.53 -1.17 -1.37 -0.33 3.15 -0.44 -0.34 -0.26 -0.1 -0.04 -1.32 0.72 0.07 -0.42 -1.3 -1.11 3.35 -0.11 -0.62 -0.59 -0.53 -0.12 -0.89 0.08 0.03 -0.59 0.07 -1.6 -0.27 -1.6 -0.09 0.23 -0.28 -0.47 0.11 0 -0.43 -1.83 -0.18 0.66 -0.98 -0.53 0.05 3.05 0.94 -0.16 -1.14 -1.11 -0.25 -1.67 -0.36 -0.54 0.11 0.76 -2.83 -0.38 -0.05 -0.16 -1.36 -0.41 -0.2 -0.59 -0.22 -0.62 -0.3 -0.21 -0.27 -0.61 0.38 -0.17 -0.75 0.08 0.17 -0.82 0.02 0.04 -0.63 -0.83 -0.02 -0.19 -0.08 -0.18 -2.31 -0.2 -0.25 0.13 -0.03 -0.04 0.42 -0.35 0.46 -0.13 -0.77 -0.45 -1.04 0.18 0 -0.02 -2.18 -1.5 0.01 -0.02 -3.69 0.42 -0.8 0.03 -0.46 -0.57 -0.9 -0.23 0.01 -1.07 -2.22 -0.89 -0.57 -1.43 0.12 -0.74 -0.09 0.27 -0.38 -0.57 -0.11 -0.72 -0.46 -0.15 0.17 -0.32 -0.29 -0.34 -0.67 0.9 -1.91 0.24 -0.66 -0.1 -0.56 -0.94 0.38 -0.41 0.2 -1.79 -0.21 0.07 -1.04 0.06 -0.54 0.17 -0.47 0 0.49 -0.11 -0.25 -0.31 -0.64 -0.49 -0.19 0.35 -0.36 -0.02 -0.84 0.77 0.82 0.46 2.11 -0.87 0.64 0.64 N-acetyl-glucosamine-1/6-phosphate 1.24 0.85 -0.93 -0.47 -0.3 -0.73 0.23 0.51 -0.08 -0.38 -0.06 0.48 0.82 1.3 -0.49 -0.41 1.91 1.53 -0.12 0.63 -1.05 1.55 -0.48 -2.23 1.6 0.52 1.51 -0.15 0.1 0.69 -0.82 0.55 -0.12 1.28 -0.89 0.04 0.4 -0.74 1.18 -0.24 -2.38 -0.26 0.11 -0.31 -1.25 0.46 0.36 0.58 0.84 1.58 0.18 0.51 0.22 0.46 0.32 -0.66 0.05 -0.21 0.96 -0.83 -0.29 0.1 -0.48 -0.33 -0.36 1.77 1 -0.21 0.41 0.99 0.12 0.24 0.77 -1.89 -0.44 2.74 -1.52 -0.44 -0.07 -0.4 0.21 -0.07 -0.7 -0.84 0.92 0.57 -0.99 -1.14 0.68 -1.25 -0.37 -0.18 -0.73 0.02 0.05 0.55 1.73 0.36 0.33 0.02 0.89 -0.04 0.16 -0.99 1.92 0.44 0.27 -0.62 -0.82 -0.32 1.85 -0.57 -0.92 2.56 -0.54 0.24 0.22 0.34 -0.01 -0.57 0.89 -0.51 -0.86 0.35 -0.29 2.57 0.69 -0.16 0.31 0.39 -0.13 -1.18 0.58 1.36 -1.01 0.48 -0.21 0.4 0.12 -0.48 0.74 0.24 0.25 -1.01 0.33 1.45 -0.44 0.05 0.15 0.22 -0.11 -0.37 -0.4 0.02 -1.5 1.06 -0.75 0.99 -1.99 0.41 -0.81 -0.17 0.73 2.34 -1.05 0.92 -0.31 0.47 0.39 1.23 0.01 0.9 0.78 -0.3 0.09 0.35 -0.55 -0.12 -0.04 0.81 -0.33 1.1 -0.48 -0.26 -0.74 -0.63 1.33 0.47 -1.52 -1.52 N-acetyl-glutamate 0.15 0.16 -0.05 -0.11 0.05 -0.58 -0.23 0.25 0.11 0.1 -0.2 0.51 0.06 0.3 0.02 -1.24 -0.07 0.24 0.05 -0.01 -0.2 0.09 -1.31 0.39 -0.04 -0.6 1.36 0.02 0.27 0.05 -0.06 0.04 -0.19 0.26 -0.07 -0.13 0 0 0.91 -0.37 0.05 -0.4 -0.07 0.07 0 -0.04 -0.08 0.18 0.17 -0.39 -1.22 0.25 0.11 -0.83 -0.09 0.13 0.03 0.08 -0.29 0.33 -0.26 0.14 0.06 -0.13 -0.11 2.39 0.17 0.13 0.01 -0.18 -0.21 -1.85 0.13 0.44 0.24 -0.13 0.4 0.39 0 -0.16 -0.13 0.57 0.29 0.18 0.32 0.16 -0.26 -1.02 0.3 0.29 0.3 0.83 -0.04 -0.2 0.11 0.05 0.05 0.16 0.82 0.07 0.01 0.19 -0.02 0.13 -0.24 0.12 0.06 0.06 0.13 0.78 0.15 0.24 -0.1 -0.01 0.33 -0.04 -0.01 0.13 0.11 0.2 -0.31 0.19 0.23 0.27 0.61 0.19 0.75 0.2 0.6 0.17 0.86 -0.02 0.07 -0.3 0.47 0.19 0.15 0.4 0.01 -1.25 0.2 0.07 -0.22 0.11 0.27 0.31 0.03 0.12 0.22 0.19 0.03 0.2 -0.27 -0.09 -0.21 0.12 0.18 0.51 0.17 0.01 0.56 0.37 0.32 -0.1 -0.17 0.16 0.22 0.57 -0.03 0.03 0.48 0.27 0.18 0.09 -0.26 -0.08 0.25 0.04 0.53 0.75 -0.08 0.71 -0.29 -0.06 0.02 0 0.17 -0.12 0.09 0.09 N-acetyl-glutamine -0.79 -0.2 -0.17 0 -0.36 -0.94 -0.95 -0.17 -0.5 -0.11 -0.24 -0.23 -0.01 -0.33 -0.34 1.1 -1.22 -0.71 -0.84 -0.69 -1.45 0.04 0.79 0.7 -0.19 0.16 -1.08 -0.18 0 0.35 0.48 0.02 -0.13 -0.63 -0.2 0.3 -0.08 -1.15 -0.41 -0.48 0.61 0.25 0.64 0.36 0.11 -0.63 -0.28 -0.39 -0.09 -0.71 0.63 -0.33 0.07 0.63 0 0.28 -0.25 0.54 -0.31 -0.71 0.18 0.21 -1.51 0.24 -0.51 -0.17 0.17 -0.12 -0.04 -0.2 0.14 -0.11 0.18 0.54 0.52 -0.22 0.67 0.18 0.15 0.19 -0.37 -0.36 0.26 0.65 0.02 -0.14 0.14 1.2 -0.02 0.28 0.06 0.48 -0.26 0.18 0.33 -0.12 -0.17 0.27 0.43 -0.29 0.31 0.11 -0.84 0.17 -0.93 -0.12 0.84 -0.31 0.79 0.12 -0.18 0.89 -0.14 -0.27 0.28 -0.73 -0.17 0.14 -0.18 -0.59 -0.85 -0.39 0.45 1.62 -0.38 -0.26 0.07 0.39 -0.03 -0.18 0.4 0.57 1.18 0.35 -0.28 0.27 -2.34 0.33 -0.14 0.68 0.12 -0.1 -0.59 -0.38 0.54 -0.7 0.18 -0.51 0.57 0.9 -1.13 0.02 -0.2 0.6 -0.37 -0.67 -0.27 0.37 1.26 -0.32 0.2 0.44 -0.5 -1.14 0.24 -0.48 -0.17 0.7 0.04 -0.4 -0.33 0.09 -0.62 -0.14 -0.21 -1.13 -0.47 -0.06 -0.13 0.16 -0.04 -0.05 -0.47 -0.13 -0.41 -0.06 0.08 -0.73 -0.31 -0.31 N-Acetyl-L-alanine 0.12 0.06 -0.31 1.22 -0.59 -0.84 -0.16 -0.27 -0.41 -0.37 -0.27 -0.71 -0.62 -0.75 -0.01 -0.09 -0.12 -0.64 -0.54 -0.24 -0.75 -0.01 -0.42 -0.42 -1 -0.39 0.21 -0.75 1.31 0.09 -0.17 0.54 0.1 0.64 -0.64 0.2 -0.97 -0.97 -0.77 0.35 0.36 -1.26 0.01 0.37 0.24 0.42 0.43 0.11 0.39 0.29 0.24 -0.36 0.33 -0.62 -0.64 0.59 -0.32 -0.04 -1.08 -0.29 0.01 0.31 0.14 -0.66 -0.19 -0.07 0 0.6 -0.41 0.04 -0.31 0.05 0.19 -0.19 0.28 -0.18 -0.18 1 0.24 -0.24 0.2 0.5 -0.63 0.64 0.43 0.76 0.02 0.02 0.41 0.3 0.08 0.47 0.07 -0.08 -0.09 0.73 -0.02 0.17 0.14 -0.38 0.29 -0.09 0.52 -0.34 -0.56 0.17 0.23 -0.1 0.23 -0.36 -0.16 0.11 -0.73 -0.37 -0.75 -0.6 -0.21 0.41 0.5 0.55 -0.48 -1.11 0.4 0.69 -0.86 -0.57 -0.22 0.84 -0.26 -0.42 -0.02 0.57 0.67 0.03 -0.43 -0.6 0.33 -0.82 0.24 -1.7 -0.11 0.53 -0.49 0.25 0.87 -0.27 0.11 0.4 0.66 -0.59 0.3 0.6 -0.45 0.32 -1.37 -0.5 -0.43 0.41 0.91 -0.16 0.59 -0.72 1.08 -0.34 -0.23 0.2 -0.51 0.15 -0.16 0.24 0.32 0.47 0.59 0.01 -0.31 0.49 0.3 -0.02 -0.35 0.41 -0.31 -0.01 -1.11 -0.52 -0.23 -0.24 0.15 -0.91 0.02 0.02 N-acetyl-L-ornithine 0.13 -0.05 -2.05 -0.2 -0.5 -3.73 -0.59 -0.23 -0.24 -0.03 -1.18 -2.25 -2.77 -2.62 1.09 -0.18 -0.06 -2.22 0.32 -2.18 -3.38 0.17 -1.69 -1.29 -3.72 -1.33 -0.83 -1.24 -0.89 0.41 -1.06 -0.46 -0.32 0.18 -0.34 0.24 -2.08 -3.54 -1.41 -0.96 -1.45 -0.18 -1.38 -1.2 -0.7 0.15 -0.17 0.1 0.07 -1.08 -0.14 -3.09 -0.73 -0.36 1.29 -0.76 -0.67 -0.27 -3.88 -2.37 -1.17 0.55 0.24 0.37 -0.09 -0.59 -0.42 -2.33 0.15 -0.51 -0.35 -1.05 -3.24 -1.62 -0.86 -0.81 -1.79 -1.76 -0.05 -0.62 -0.31 -0.45 -1.7 -1.4 -0.62 -1.98 -0.21 -1.18 2.05 -1.91 1.88 -0.09 -1.58 -0.12 0.36 1.17 1.49 -0.05 -0.82 -0.01 -0.7 -2.13 -0.08 -3.34 -2.19 -0.48 -0.85 0.2 -0.7 -2.75 0.96 -0.95 -1.14 -0.41 -1.78 -1.4 0.04 0.03 -0.22 -0.68 -2.27 -3.01 -1.07 -0.32 -2.68 -0.59 -1.05 -1.6 -2.35 -1.98 -2.88 -0.73 -0.32 -3.46 -2.17 -1.91 -0.42 -2.77 -0.11 -2.8 -0.25 0.03 -2.28 -0.01 -1.54 -2.27 -0.05 0.13 -1.07 -1.29 0 -1.89 -0.31 0.39 -3.4 -2.14 -2.69 -0.46 -1.54 -1.6 0.25 -3.6 0.09 -0.63 -0.38 -0.14 -2.15 0.3 -0.27 -0.19 1.44 -0.17 -0.36 -0.06 -0.33 -0.54 -0.31 0.95 -3.11 0.24 0.03 0.32 -2.87 -0.05 -0.14 -0.06 0.16 -3.11 0.2 0.2 N-carbamoyl-L-aspartate 3.73 3.75 -0.6 0.01 -0.86 -2.19 2.41 4.34 4.27 -0.18 -2.36 -0.86 -1.37 -1.52 0.58 -0.13 4.7 -0.65 -0.04 -0.44 -2.47 3.48 1.85 -1.92 2.25 -1.29 2.27 -1.24 1.62 0.82 0.2 0.75 0.24 4.48 0.04 0.03 -3.4 -2.58 -1.36 2.31 2.77 -0.91 -0.2 -0.39 5.73 3.12 1.99 2.97 4.52 0.5 3.2 -1.64 4.71 -1.8 4.42 5.68 4.17 0.45 2.65 -0.32 -0.23 0.14 3.35 0.31 3.95 0.57 -0.32 1.74 3.87 4.68 3.64 -1.55 -1.16 1.69 0.31 4.33 -1.95 0.87 0.05 1.47 0.87 1.89 -0.82 1.81 3.8 0.61 0.67 -0.14 4.64 4.58 0.95 0.51 -0.03 0.09 0.31 4.61 -0.34 0.15 0.61 -0.36 0.02 2.42 0.32 0.17 -1.59 3.49 0.21 -0.26 -0.26 2.83 0.14 -0.55 -0.26 -0.84 -1.83 0.33 1.5 2.29 1.15 0.1 -1.47 -2.07 -0.44 0.68 -2.23 -1.08 1.25 -0.23 -1.04 -1.14 -1.34 0.32 -0.43 -2.11 -2.29 -2.29 -0.77 -2.6 0.83 -1.59 4.03 2.07 -2.03 -0.26 0.37 -3.03 -1.27 0.03 0.41 -0.79 3.34 -1.16 0.05 -0.21 -2.19 -1.02 -1.45 4.18 0.54 3.79 0.72 0.6 0.46 0.27 0.17 0.02 -1.43 1.02 0.17 2.9 -0.04 3.89 0.99 3.66 0.53 3.64 0.68 -0.17 -1.24 3.17 -0.37 4.18 -2.79 -0.21 -0.34 -0.52 0.31 -2.7 0.03 0.03 NAD+ 0.03 0.07 0.01 0.27 0.07 0.08 -0.2 0.06 0.05 0.13 -0.31 -0.19 -0.11 -0.06 -0.31 -0.16 0.03 -0.28 0.12 -0.45 -0.4 0.04 -0.41 -0.11 -0.17 -0.05 0.64 -0.37 -0.92 0.05 0.04 -0.02 -0.1 0.06 -0.08 0 0.78 -0.49 0.65 -0.2 0.03 -0.29 -0.08 0 0.1 0.05 1.32 0.12 -0.01 0 -0.08 -0.1 0.08 -0.17 -0.2 0.16 -0.04 0.05 0.01 -0.3 -0.13 0.1 -0.33 -0.07 -0.06 0.04 -0.16 -0.01 0 0.01 -0.2 -0.64 0 0.05 0.01 -0.16 -0.14 -0.12 0.86 -0.13 -0.04 0.07 -0.06 0.08 0.17 -0.14 -0.17 -0.02 0.1 0.07 -0.12 0.01 -0.13 -0.13 -0.02 -0.02 0 0.05 0.82 -0.18 0 -0.15 0.03 -0.12 -0.37 0.02 -0.13 0.02 0.04 -0.28 0.16 -0.44 0.04 -0.12 -0.16 -0.01 -0.08 0.01 0.69 0.09 -0.37 -0.21 -0.01 0.11 -0.48 -0.03 0.96 -0.01 0.01 -0.03 -0.28 -0.04 -0.06 -0.21 -0.3 -0.44 -0.97 0.04 -0.03 -0.16 -0.1 -0.36 0.99 -1.01 0.02 0.05 0 0.07 0.29 0 -1.25 0.03 -0.26 0.09 -0.21 -0.2 -0.03 -0.03 0.07 0.04 0.6 -0.03 0 -0.1 -0.2 0.06 -0.13 -0.08 -0.06 -0.03 0.05 0.15 0.03 0.09 -0.15 -0.1 -0.03 0.04 0.07 0.39 0.19 0.37 -0.35 0.07 0.01 0.06 0.01 -0.4 0.17 0.17 NADH 1.27 1.02 -0.07 0.58 0 5.17 0.08 0.2 1.29 0.16 -1.35 0.12 0.62 -0.89 -0.73 0.41 -0.2 1.23 -1.59 0.63 2.5 3.23 3.81 -0.58 3.63 0.34 0.85 -2.19 -0.32 0.01 0.58 -0.62 0.73 0.16 -0.49 -0.71 -0.44 1.83 -0.29 2.86 0.96 -0.42 -0.16 1.08 -2.43 1.47 0.84 -0.18 0.22 1.11 -0.54 1.34 0.55 -0.49 -0.31 -1.91 -0.07 1.41 -1.78 0.05 -1.34 0.44 -0.6 2.77 0.48 0.98 -0.51 -0.3 0.76 1.67 -0.44 -2.82 -1.63 0.5 2.5 -0.58 0.85 -0.38 -0.33 3.49 0.41 1.04 0.33 0.18 -0.04 -1.05 2.83 1.82 1.14 1 0.45 0.44 -3.6 0.46 0.65 1.76 -0.48 1.83 0.67 -0.45 -0.47 1.24 2.33 -0.5 0.36 0.08 0.18 1.01 0.84 -0.08 4.96 -2.93 0.09 0.09 -1.42 1.77 1.14 -0.03 -0.26 1.83 0 -0.71 -0.12 -0.17 0.58 -0.93 0.54 0.74 1.1 -2.23 0.06 1.46 0.61 0.91 0.12 -0.47 -0.61 0.58 0.79 1.5 -0.01 -0.51 0.17 -0.67 0.54 0.65 -0.2 0.29 -1.16 0.38 -0.66 0.55 -0.04 -0.46 -0.19 0.24 -0.58 0.06 1.6 -2.2 0.86 3.3 0.02 1.21 -0.59 1.31 -3.47 1.69 -0.56 0.93 0.92 -0.49 0.35 -0.02 0.01 -0.51 -1.74 -0.04 1.32 0.65 -0.23 1.32 0 0.02 0.77 0 4.9 0.71 3.14 3.14 NADP+ -0.16 0.02 -0.05 -0.14 0.03 0.08 -0.19 0.03 -0.01 -0.02 -0.05 -0.04 0.12 0.1 -0.01 -0.1 0.54 0.46 -0.14 0.37 -0.02 0.1 -0.45 0.24 -0.3 -0.17 1.02 0 0.03 0.13 -0.06 0.21 0.1 0.48 -0.22 -0.04 0.31 0 1.1 -0.53 -0.47 -0.04 -0.11 -0.27 -0.03 -0.23 -0.26 0.21 0.21 0.98 -0.33 -0.22 -0.02 -0.27 0.01 0 -0.19 -0.08 -0.18 -0.37 -0.24 0.27 0.07 -0.04 -0.23 0.56 0.31 -0.16 0.14 0.57 -0.29 -0.43 0.05 0.26 -0.22 -0.32 0.22 -0.08 -0.01 -0.35 0.16 -0.03 0.06 0.04 0.12 -0.1 -0.27 -0.22 0.07 0.02 -0.37 -0.22 -0.07 -0.23 -0.13 0.18 0 0 -0.07 -0.2 -0.08 0.12 -0.31 0.03 -0.21 -0.06 -0.17 -0.03 -0.07 -0.46 -0.11 -0.32 0.06 0.08 0.02 -0.24 0.11 0.23 -0.11 -0.14 -0.25 -0.18 -0.06 -0.03 -0.09 0.06 0.1 0.03 0.07 0.15 -0.24 -0.43 -0.17 -0.42 -0.63 0.06 0.06 0.35 -0.18 0.03 -0.12 -0.23 -0.29 0.07 -0.14 0.24 -0.17 0.12 0.13 0.11 0.01 -0.18 -0.15 0.19 -0.43 -0.17 0.38 -0.22 -0.29 -0.13 0.5 -0.09 -0.07 1.06 -0.14 -0.03 0.17 -0.33 -0.01 -0.2 -0.01 -0.04 0.59 -0.19 -0.16 -0.31 -0.15 0.03 0.01 0.17 -0.03 -0.14 0.06 0.21 -0.03 0.04 0.03 0.09 0.03 0.03 NADPH 0.89 0.23 0.23 0.37 -0.25 1.58 -0.39 1.25 3.74 0.75 0.51 0.76 0.26 -3.42 0.42 0.32 -3.35 1.11 -0.82 0.03 2.41 2.43 2.92 -0.45 1.75 2.06 1.13 -1.15 0.07 -0.62 0.6 0.12 1.33 1.09 -0.15 -0.14 -0.46 1.98 1.24 1.9 2.08 -0.26 0.22 1.73 -2.19 0.57 -0.43 -0.5 0.3 0.04 -0.16 -2.68 0.08 -0.4 -0.67 -0.76 0.68 1.5 -5.45 0.47 -1.39 0.49 0.44 2.23 0.83 0.67 0.37 1.18 1.18 1.18 -0.34 -0.48 -0.47 0.45 -0.13 -3.35 0.41 0.75 -0.39 1.6 1.06 1.02 1.09 0.59 -0.49 -0.77 1.08 2.69 0.88 0.28 1.48 0.59 -1.39 0.61 0.78 0.62 -0.71 1.08 0.83 0.91 -0.76 1.75 1.6 -0.2 -1.02 0.52 0.49 1.09 -0.14 -0.02 3.65 -3.92 -0.59 -0.91 0.11 1.36 1.59 0.33 -0.09 1.09 -3.34 1.85 -0.43 0.46 0.33 -0.53 0.36 0.83 0.26 0.34 -0.64 1.94 -1.05 -3.32 0.64 -0.33 0.71 0.66 1.76 0.9 0.18 -0.76 -0.66 0.28 0.43 0.86 0.83 0.53 -0.12 0.85 0.9 -0.73 0.12 -0.72 -1.71 0.28 -2.59 -0.47 -1.25 -1.74 1.03 3.74 0.25 1.24 -0.03 1 -1.93 1.45 -0.33 0.91 1.22 -0.68 1.56 0.95 1.45 -1.99 -1.17 0.93 0.54 0.28 -0.03 0.86 -0.12 -0.05 1.13 0.45 1.81 4.21 0.5 0.5 nicotinate -0.28 0.07 0.05 0.09 0.08 1.1 -0.74 0.11 -0.17 0.1 1.18 0.05 0.13 0.49 0.13 1.08 -0.48 -0.28 0.03 0.4 1.19 0.19 0.6 1.2 0.17 -0.2 -0.42 0.18 -0.17 -0.09 -0.1 -0.23 -1.05 -0.56 -0.03 -0.1 0.58 0.94 0.1 -0.56 0.88 -0.18 -0.42 0.43 0.53 -0.22 -0.23 -0.66 -0.42 -0.82 0.78 0.18 0.37 0.11 0.19 0.43 -0.08 0.34 -0.3 0.93 0.1 -0.13 0.43 0.19 -0.23 0.34 0.31 -0.23 -1.37 -0.29 -0.91 1.09 0.22 0.94 -0.25 -0.29 1.91 -0.09 -0.04 -0.2 -1.28 0.07 0.58 0.92 0.96 -0.14 -0.06 1.49 0.51 0.46 0.27 -0.41 0.52 0.16 -0.11 -0.27 -0.23 0.03 0.78 0.02 0.67 0.02 -0.07 0.26 0.59 0.05 -0.32 -0.03 0.21 -0.73 0.02 -0.25 0.16 -0.12 1 -0.18 -1.01 -0.23 0.15 0.43 0.59 0.98 0.31 -0.23 0.52 0.15 0.06 0.69 -0.04 0.67 0.36 0.01 -0.41 0.3 1.08 1.01 0.24 1.36 0.01 0.23 -0.02 0.11 0.29 0.21 0.3 1.06 0.56 -0.01 0.46 0.2 -0.09 0.03 -0.46 -0.17 0.56 -0.37 0.23 0.03 -0.47 0.22 0.81 -0.02 0.1 -1.01 0.13 -0.49 0.63 0.14 -0.15 -0.41 0.05 0.17 -0.64 -0.14 -0.52 -0.56 0.01 -0.09 0.18 0.32 -0.13 0.13 0.53 -0.26 0.17 0.09 0.2 0.94 0.23 0.23 Octoluse 8/1-phosphate 0.34 0.12 -0.21 -0.12 -0.35 0.24 -0.46 0.31 -0.47 0 -0.95 0.1 0.04 -0.27 1.29 0.09 0.11 0.48 0.03 0.3 -0.85 0.12 -0.09 -0.02 -0.2 0 0.45 -0.28 0.95 0.13 -0.09 -0.06 -0.33 0.52 -0.23 -0.62 -0.34 -0.74 -0.06 0.23 0.12 -0.16 -0.64 0.06 -0.49 0.11 -0.07 0.22 0.32 0.24 0.23 -0.14 0.09 -0.02 -0.07 -0.39 -0.12 0.21 -0.49 -0.21 0.1 0.34 0.95 -0.37 -0.13 0.88 0.44 -0.16 -0.15 -0.2 -0.61 0.35 0.05 0.16 0.92 -0.78 -0.21 -0.4 -0.43 -0.49 -0.37 0.22 -0.07 0.21 -0.74 -0.13 -0.58 -0.1 0.18 0.08 -0.07 0.71 -1.16 -0.36 -0.15 -0.27 -0.18 0.16 -0.05 -0.19 -0.44 -0.21 0.22 -0.44 -0.31 -0.01 0.3 -0.04 -0.11 0.46 -0.01 0.63 -0.22 -0.66 -0.41 0.62 -0.38 0.41 -0.13 -0.38 -0.6 -0.58 -0.02 0.04 -0.23 0.23 0.09 0.22 0.08 -0.73 0.77 -0.69 0.3 -0.17 -0.1 -0.46 -0.18 -0.08 0.19 -0.61 -0.06 -0.11 -1 0.8 -0.51 0.19 0.19 0.14 0.01 -0.07 0.43 0.66 -1.04 0.16 -0.53 0.23 -0.09 0.83 0.01 -0.85 0.38 -0.15 0.51 0.71 -0.63 0.49 -1.12 1.51 -0.05 0.34 0.19 0.33 0.36 -0.14 -0.37 0.07 0.04 1.2 0.72 0.39 0.64 0.29 -0.88 0.2 -0.59 -0.41 -0.11 -0.33 0 0 Octoluse Bisphosphate 0.08 0.01 0.56 -0.15 0.05 -6.3 -0.43 -0.08 -0.05 0.07 -1.21 -0.4 0.31 0.04 -0.13 -0.28 -0.46 -0.12 -0.16 -1.74 -2.19 -0.19 -1.18 -1.42 -0.38 1.36 0.4 -0.25 -0.39 -0.03 -0.39 0.02 0.74 0.02 -0.24 -0.37 -2.06 -2.07 0.12 -0.21 -0.71 -0.36 -0.51 -0.43 -0.25 -0.12 -0.3 0.16 -0.09 -0.38 -0.26 -2.19 -0.41 0.73 -0.11 -0.07 -0.23 -0.09 0.14 -2.06 -0.72 0.76 -0.24 -0.26 -0.04 0.09 0.24 -0.44 0.09 0.02 -0.41 -1.35 -0.2 -0.39 -0.37 -0.14 -5.42 -0.78 -0.22 -0.86 -0.09 -0.32 -0.1 -0.75 -0.04 0.3 -1.08 -0.63 -0.29 -0.75 -0.37 -0.48 -0.46 -0.51 -0.51 -0.11 0.1 0.07 -0.45 -0.56 -0.51 -0.38 -0.47 -0.25 -2.86 -0.09 -0.09 0.22 0.27 -0.79 0.16 0.44 -0.65 0.19 -1.59 -0.37 -0.09 -0.15 -0.56 -0.42 -2.27 -1.77 -0.24 -0.02 -1.81 -0.21 -0.36 -0.57 -0.17 -0.32 -2.08 -0.97 -0.03 -2.34 -1.72 -1.16 -0.55 -2.14 -0.24 -2.66 0.03 -0.2 -2.49 -0.18 -0.18 -1.83 -0.42 -0.11 0.09 -0.39 -0.14 -0.09 -0.34 0.54 -3.3 -0.34 -0.45 0.02 -0.34 0.07 0.08 -0.51 -0.05 0.1 -0.86 0.18 -0.14 -0.17 -0.45 -0.18 -0.29 -0.09 -0.04 -0.2 -0.36 -0.31 -0.53 -0.3 0.22 0.21 -0.2 0.12 -2.51 0.06 -0.03 0.17 0.17 -2.31 0.08 0.08 ornithine 0.28 0.11 -0.19 -0.28 0.26 -0.03 -0.01 0.13 -0.04 -0.05 0.13 0.18 0.09 -0.02 -0.14 -0.49 0.69 0.8 -0.14 0.36 0.01 0.23 -0.03 -0.04 0.14 0.09 -0.21 -0.29 -0.79 0.3 0.15 -0.12 0.32 -0.28 0.04 0.03 0.03 -0.11 -0.22 -0.09 0.09 -0.27 -0.05 -0.07 -0.66 0.27 -0.09 -0.07 -0.2 0.76 0.08 -0.24 -0.02 0.47 0.07 -0.31 0.11 0.41 0.11 -0.23 -0.15 0.07 -0.01 -0.04 0.04 -0.06 0.38 -0.19 0.03 0.1 -0.11 0.16 0.12 -0.03 -0.64 0.31 0.08 0.01 0.29 -0.33 0.05 0.08 -0.08 0.17 0.46 -0.43 -0.11 -0.13 -0.11 0.07 0.04 0.02 0.22 0.05 -0.09 -0.03 0.05 -0.16 -0.5 -0.02 -0.32 0.05 0.34 0.15 0.14 0.05 -0.22 0.04 0.2 0 0.18 -0.47 -0.07 0.25 -0.02 -0.02 0.15 0.09 0.23 0.13 0.18 0.07 -0.05 0.18 0.24 0.49 -0.49 0.14 -0.38 0.11 0.16 0.3 -0.29 -0.25 -0.1 -0.39 -0.65 0.32 -0.11 0.2 0.05 0.02 0.19 -0.47 0.16 0.12 0.17 0.02 -1 0.29 0.42 -0.64 -0.31 0.14 -0.28 0.09 -0.02 0.6 -0.38 0.09 0.37 -0.12 -0.27 0.66 -0.02 -0.03 0.07 0.54 0.01 0.15 -0.23 0.09 0.1 0.08 -0.08 -0.27 -0.04 -0.13 -0.28 0.18 0.2 0.15 0 -0.05 -0.36 -0.01 -0.06 -0.01 0.05 0.05 orotate 0.14 -0.09 -0.05 0.11 -0.73 1.16 -2.84 -0.5 -0.37 -0.17 0.15 -0.88 -1.33 -0.7 0.72 0.33 0.78 -1.7 -0.31 -0.35 -0.06 1.43 0.15 0.03 -0.12 -1.24 -0.02 -1.47 0.82 -0.05 -0.17 0.36 -0.41 0.18 -0.08 0.5 0.43 -0.18 -1.33 2.26 1.7 -0.88 -0.12 -0.02 0.43 -0.05 -1.87 -1.51 -0.12 -0.76 0.28 -0.04 0.98 -2.22 2.73 2.26 1.08 0.38 -0.36 0.75 0.51 0.12 1.33 -0.15 1.62 -0.33 -0.52 0.45 -1.97 -0.23 -1.59 1.61 -1.27 0.01 -0.23 -1.09 1.97 0.33 -0.2 0.06 -0.73 0.82 -0.96 1.93 -0.13 0.45 0.12 0.24 2.55 -0.08 0.87 -0.1 0.43 0.07 -0.36 0.07 -0.95 0.04 0.09 -0.28 0.24 1.19 0.32 -0.6 1.34 -0.39 -0.93 -0.46 -0.59 0.52 0.03 -1.95 -0.12 -0.82 0.11 0.57 -0.24 1.54 -0.22 0.14 1.2 0.87 -0.6 -0.5 -0.72 -0.6 -0.14 -0.08 -0.91 -0.39 0.72 -0.5 -0.98 -0.2 0.4 0.05 -0.1 0.71 -0.13 -1.2 0.22 -1.92 0.21 -0.01 -0.48 0.45 -0.37 -0.2 0.34 -0.67 1.54 -1.11 -0.42 0.16 0.71 -1.06 -1.13 -1.14 -0.73 -0.38 0.45 -0.31 0.52 -0.91 -0.2 -0.58 -0.83 0.35 -0.21 1.21 -0.23 -0.31 -0.35 -1.04 0.05 -0.88 0.31 0.01 -0.79 -0.92 0.04 -0.61 0.6 -0.23 -0.05 -0.51 0.09 0.43 0.09 0.09 p-hydroxybenzoate 0.27 -0.07 0.26 -2.57 0.01 -0.03 -1.66 -0.02 -0.19 -0.05 0.11 0.26 -0.24 0.91 0 -0.06 -0.88 -0.48 0.66 -0.49 0.5 -0.74 -0.83 0.48 -0.16 -0.11 0.17 -0.22 0 -0.49 0.09 -0.02 -0.52 -0.26 0.08 0.86 0 0.05 0.44 -1.24 0.52 0.08 -0.1 0.26 0.61 -1.5 -0.09 -0.16 0.07 -0.52 -0.2 -0.87 0.01 0.15 -0.08 0.33 -0.37 0.33 -0.29 -0.03 -0.01 0.08 0.54 0.09 -0.57 0.46 0.31 -0.46 -0.77 -0.14 -0.45 0 -0.9 0.47 -0.37 -0.21 0.7 0.05 0.35 0.31 -0.81 -0.31 -0.26 0.63 0.42 -0.22 0.17 0.46 0.26 0.35 0.35 -0.44 0.02 0 -0.35 -2.14 -0.39 0.47 1.1 0.09 0.28 -0.15 0.02 -0.09 -0.12 0.16 -0.25 -0.55 0.03 -0.63 -0.67 -0.58 -0.13 -0.22 -0.31 -0.26 -0.5 -0.07 -0.16 -0.47 0.07 -0.33 0.19 -0.32 -0.01 -0.06 -0.47 0.33 0.04 -0.05 0.5 0.23 -0.64 -0.52 0.28 -0.08 0.04 0.7 0.63 0.45 -0.33 0.18 -0.66 0.67 0.4 0.42 0.07 0.11 0.39 0.56 0.04 -0.87 0.08 0.28 -0.61 -0.07 0.13 0.39 -0.15 0.36 0.94 0.13 -0.11 -1 0.4 -0.18 -0.73 0.49 0.24 -0.18 -0.18 0.35 -0.06 0.05 -0.38 0.39 -0.81 0 -0.47 -0.14 0 0.71 -0.22 0 0.24 0 -0.06 -0.16 0.13 0.13 PD 0.39 0.15 -1.05 -0.44 -0.19 -2.26 -0.21 -0.03 0.11 0.11 -0.79 -2.89 -1.84 -2.09 -0.62 0.02 0.28 -2.63 0 -1.09 -2.99 -0.8 -0.56 -1.19 -2.55 0.63 -0.21 -1.27 -0.85 1.09 -0.92 0.17 -0.52 0.67 -0.19 0.04 -1.18 -2.85 -1.74 -1.16 -0.02 -0.47 -0.93 -0.4 -0.31 0.25 0.37 0.33 0.4 -0.85 0.19 -1.74 -0.52 0.58 0.18 -0.37 -0.14 -0.71 -1.87 -1.46 -1 0.25 -0.47 0.27 0.36 -0.49 -0.88 -1.24 0.12 0.25 -0.31 -0.45 -1.84 -1.62 -0.78 -0.33 -1.13 -2.35 0.1 -1.44 -0.65 -0.88 -0.94 -0.43 -0.04 -1.72 -0.55 -1.17 0.79 -0.84 -0.27 -0.81 -0.26 -0.93 -0.1 0.82 0.07 0.13 -1.6 -1.04 -1.15 -0.71 -0.65 -2.53 -0.26 0.08 -0.13 0.21 -0.51 -2.24 1.03 0.97 -0.91 -0.34 -0.9 -2.53 -0.21 0.1 -0.51 -0.25 -0.34 -1.14 -0.34 -0.26 -1.82 -0.34 -0.96 0.08 -2.3 -1.04 -0.99 -0.82 -0.58 -2.25 -1.59 -1.16 -1.06 -1.92 -0.62 -2.68 -0.01 0.39 -1.32 -0.45 -1 -1.3 -0.45 0.06 -0.74 -1.26 -0.04 -2.71 -0.32 0.13 -2.59 -3.23 -4.15 -0.02 -1.03 -0.98 -0.44 -4.47 -0.01 -0.58 -0.2 -0.02 -1.36 -1.15 -0.69 -0.03 -0.73 0.14 1 0.12 -0.01 -0.21 -0.35 -0.26 -3.94 0.59 -0.24 0.39 -1.1 0.26 -0.12 0.03 0.18 -1.26 0 0 PE 0.08 0.09 -2.27 -0.41 -0.36 -2.43 -0.44 -0.38 -0.31 0.04 -1.06 -2.09 -1.02 -1.31 0.78 0.03 0.01 -2.1 0.39 -1.8 -3.84 -0.9 -1.28 0.32 -2.93 -1.4 3.02 -0.24 -0.55 1 -0.98 0.19 0.37 0.82 -0.35 0.55 -2.8 -3.81 2.16 -0.21 0.95 0.36 -0.67 -0.08 -0.66 0.3 0.04 0.32 0.44 -1.23 0.02 -3.16 -1.14 0.87 0.79 -0.84 -0.78 -0.7 -1.94 -1.46 -1.24 0.35 -0.02 0.92 0.15 2.59 -0.92 -1.94 0.18 -0.6 -0.25 -1.41 -2.73 0 -1 -0.78 0.09 -1.74 -0.02 -0.4 -0.67 -0.31 0.38 -0.64 -0.37 -2.07 -0.12 -1.45 2.03 -1.64 1.21 -0.16 0.23 -0.36 0.81 1.06 1 0.06 -0.72 0.43 -0.9 -0.68 -0.31 -1.99 -1.01 -0.19 -0.1 0.36 -0.28 -2.54 1.83 0.2 -1.63 0.78 0.39 -1.44 -0.17 0.31 -0.21 -0.26 -0.88 -1.35 -0.36 -0.18 -1.15 1.07 -1.09 -1.72 -2.29 -0.06 -1.68 -0.92 -0.69 -3.84 -1.62 -0.35 0.19 -3.22 -0.51 -1.42 -0.19 0.15 -2.13 -0.12 -1.11 -2.68 -0.22 0.43 -0.92 0.39 0.1 -3.23 -0.13 0.18 -3.88 -3.38 -3.11 -0.19 -1.2 -1.76 0.56 -3.9 0.33 -0.8 -0.33 -0.53 -0.32 0.12 -0.29 -0.28 1.06 0.14 0.42 -0.03 -0.09 -0.24 -0.12 0.88 -3.9 0.37 -0.04 0.24 -1.92 0.18 -0.16 -0.02 -0.02 -2.22 0.08 0.08 PEE -0.19 -0.15 -1.95 -0.3 -0.61 0.21 -0.51 -0.48 -0.43 -0.11 -1.17 -1.21 -1.93 -2.57 1.48 0.14 0.04 -1.41 1.28 -1.68 -3.51 -1.96 -1.13 0.11 -4.9 -2.11 -5.81 -0.92 0.08 0.27 -1.22 0.16 0.82 0.42 0.09 0.68 -3.67 -3.54 -6.26 -0.31 1.12 -0.69 -1.28 -0.46 -0.47 0.15 -0.28 0.16 0.39 -1.17 -0.13 -3.47 -1.33 -0.16 0.68 -0.78 -1 -0.42 -3.46 -1.53 -1.5 0.56 0.78 0.5 0.01 -0.81 -0.72 -2.28 0.29 -0.47 -0.46 -2.66 -4.03 -0.81 -1.22 -1.16 0.29 -1.37 0 -0.41 -0.29 -0.35 0.15 -0.55 -0.45 -2.5 0.51 -1.66 1.76 -2.17 1.4 2.06 0.38 -0.46 0.44 1.01 0.76 0.04 -0.29 1.32 -0.77 -0.99 -0.19 -3.51 -1.55 -0.6 0.03 0.37 -0.05 0.09 1.43 -0.77 -2.25 0.32 -0.01 -2.1 0.38 0.15 -0.13 -0.28 -1.53 -1.63 -0.29 -0.33 -1.59 0.36 -1.34 -2.08 -2.1 -0.59 5.21 -0.73 -0.79 -4.65 -2.23 -0.58 1.09 -3.64 -0.72 0.23 -0.41 -0.28 -2.78 0.64 -1.41 -3.41 0 0.44 -0.72 0 0.77 -2.97 -0.02 0.3 -4.58 -2.96 -2.56 2.36 -0.74 -2.31 1.12 -3.99 0.26 -0.19 -0.2 -0.52 -0.92 0.34 0.18 -0.44 0.96 -0.21 -0.05 -0.18 -0.03 -0.37 -0.12 1.94 -4.24 -0.05 0.29 0.07 -2.4 -0.04 -0.34 -0.25 -0.12 -2.73 0.04 0.04 PEEK -0.16 -0.23 -2.12 -0.08 -0.39 0 -0.48 -0.14 -0.47 -0.09 -2.56 -1.25 -3.9 -5.5 0.28 0.11 0.83 -0.87 3.86 -0.82 -5.91 -1.68 0.23 -1.34 -2.11 -2.63 -3.25 -2.79 -0.7 0.12 -1.31 0.05 0.84 0.47 -0.28 0.55 -5.09 -4.34 -3.54 -0.5 0.73 -0.28 -3.28 -0.58 -0.57 0.3 -0.34 0.07 0.4 -0.74 -0.22 -2.47 -1.23 -0.96 1.22 -0.81 -1.14 0.41 -6.84 -2.99 -1.78 0.56 -0.12 0.79 -0.1 -1.05 -0.97 -3.04 0.86 -0.48 -0.57 -3.15 -6.76 -2.9 -0.99 -1.45 -0.42 -1.59 -0.08 1.34 0.02 -0.48 -1.42 -0.74 -0.35 -2.73 2.07 -2.08 1.41 -3.01 1.18 0.01 1.99 -0.64 0.1 0.78 1.42 -0.01 -1.23 2.54 -0.9 -0.84 -0.17 0 -4.14 -1.08 -0.04 0.28 -0.21 -2.99 2.07 -0.85 -2.55 -1.28 -1.53 0.28 0.8 0.4 -0.35 -0.42 -4.88 -3.78 -0.48 -0.49 -2.64 -1.69 -1.75 -1.32 -3.28 -4.59 -1.57 -0.74 -1.17 -3.22 -4.39 -2.13 -0.12 -2.84 -0.76 -0.89 -0.5 -0.21 -3.9 -0.15 -2.66 -2.57 -0.37 0.58 -0.54 0.3 -0.35 -2.91 -0.09 0.33 -3.01 -2.77 -2.56 -0.49 -0.1 -4.72 0.7 -3.95 0.13 1.28 -0.15 -0.5 -4.01 0.36 1.12 -0.19 0.91 -0.22 0.44 -0.23 0.04 -0.43 -0.1 0.63 -2.34 -0.13 0.22 0.04 -3.43 -0.06 -0.3 -0.11 0 -3.24 0 0 phenylpyruvate -0.4 0.08 1.72 0.49 0.19 0.26 0.27 0.61 2.11 0.72 -0.21 -0.84 -0.08 0.42 -0.79 0.31 -0.57 0.16 0.86 -0.21 0.26 -0.17 -0.05 0.9 -0.04 -0.1 0.16 0.01 0.01 -0.08 -0.06 -0.37 -0.04 -0.86 -0.34 0.11 -0.49 0.22 0.11 0.04 1.14 0.26 0.12 0.74 -0.12 0.03 -0.35 -0.31 -0.03 -0.27 -0.11 -0.35 0.73 0.14 0.14 0.35 1.46 0 0.04 -0.3 -0.14 0.01 -0.7 0.34 1.7 0.66 0.23 1.29 -0.2 -0.1 -0.75 0.04 0 0.85 1.28 -0.37 1.21 0.15 -0.46 0.59 -0.57 -0.68 1.17 1.11 0.45 0.06 0.51 0.38 0.67 0.82 -0.09 -0.39 0.11 -0.18 1.07 -0.05 -0.49 0.35 -0.52 -0.16 0.13 0.35 -0.37 -0.23 -0.32 -0.05 0.32 0.08 0.77 -0.67 -0.23 -0.46 2.12 -0.23 0.26 -0.36 0.12 0.03 -0.26 0.08 -0.07 0.8 0.57 1.33 -0.33 -0.53 -0.02 0.88 0.03 -0.08 0.02 0.47 1.22 0.38 0.09 0.23 -2.27 0.9 -0.04 0.6 0.25 -0.06 -0.47 -1.09 0.03 0.12 0.03 -0.38 -0.12 0.03 -0.98 -0.28 -0.19 -0.77 -0.39 -0.57 -0.35 0 0.84 0.12 0.65 -0.05 0.04 -0.4 0.47 0.1 0.1 0 -0.67 -0.52 -0.58 0.1 -1.34 0.18 -0.27 -0.48 -0.62 -0.33 -0.17 0.23 -0.1 -0.17 -0.06 1.13 1.37 0.89 0.53 1.21 0.48 0.48 phosphoenolpyruvate 0.06 0.07 -0.09 -0.17 0.08 -2.24 -0.32 0.1 -0.15 -0.05 -0.19 0.41 0.64 0.4 -0.45 -0.09 -0.11 0.19 -0.32 -0.52 0.52 1.16 -0.46 0.33 -0.17 1.42 0.02 -0.04 0.26 -0.31 -0.36 0.11 -0.33 -0.12 -0.14 -0.32 0.21 0.45 0.01 -0.73 -0.2 0 -0.56 -0.19 -0.03 -0.17 -0.5 -0.1 -0.24 -0.25 -0.37 -0.04 0.21 1.1 0.17 0.05 -0.66 0.06 -0.55 -0.07 -0.16 0.04 -0.15 -0.11 -0.83 0.19 0.77 -0.23 -0.51 0.05 -0.75 -0.21 0.76 0.91 0.19 -0.68 0.76 -0.3 -0.12 -0.47 0.03 -0.15 0.13 -0.16 0.91 0.41 -0.47 0.09 -0.09 -0.2 -0.24 -0.47 -0.4 -0.3 -0.23 -0.39 -0.15 0.09 0.07 0.07 0.1 -0.09 -0.34 -0.09 -0.01 -0.14 -0.14 -0.32 -0.02 -0.51 0.07 -0.29 -0.42 0.17 0.02 -0.28 -0.3 0.06 -0.04 -0.06 -0.21 -0.41 0.26 0.09 -0.01 -0.29 -0.17 0.33 0.89 0.07 -0.38 -0.55 0.05 -0.3 -0.21 0.44 -0.09 0.17 0.33 -0.02 0.07 -0.29 -0.24 -0.25 -0.22 0.63 0.04 0.01 0.23 -0.23 -0.22 -0.13 -0.55 0.02 -0.99 0.38 0.14 -0.45 0.68 -0.15 0.3 -0.27 0.46 0.16 -0.34 0.08 0.11 -0.52 0.18 0.02 -0.14 0.15 0.41 -0.34 -0.49 0.49 -0.12 -0.17 0.28 0.15 -0.22 0.62 0.13 -0.2 -0.11 -0.03 -0.01 0.2 0 0 PVNF -0.59 -0.49 -3.68 -0.39 -0.8 0 -1.06 -0.71 -0.59 0.01 -2.22 -4.74 -4.51 -3.74 -0.35 -0.17 -0.77 -3.88 0.3 -4.09 -6.64 -1.62 -3.34 -3.13 -8.67 -2.16 -1.55 -3.31 -1.82 -0.26 -1.19 0.15 -2.1 -0.94 -0.22 0.44 -5.24 -6.51 -1.5 -3.76 -1.95 0.76 -1.79 -1.49 -0.75 -0.85 -1.61 0.26 -0.95 -1.9 -0.46 -5.25 -2.5 -0.33 0.72 -0.94 -2.69 0.23 -8.03 -3.97 -3.22 -0.06 -0.24 0.71 -1.96 -0.87 -0.61 -3.45 0.23 -1.47 -0.5 -4.15 -5.2 -3.7 -2.35 -1.36 -4.68 -2.58 -0.19 -0.85 -0.85 -1.34 -3.57 -2.03 -2.05 -3.16 0.23 -4.13 0.34 -3.71 0.29 -1.34 -2.69 -1.36 -0.46 0.29 -0.15 0.1 -1.61 0.09 -1.33 -1.51 -3.02 -5.86 -4.09 -1.57 0.16 0.01 -0.62 -2.78 1.29 -0.96 -1.6 -2.39 -3.81 -4.98 0.48 -0.38 -2.31 -2.68 -4.11 -5.48 0.09 -0.57 -5.39 -3.12 -1.44 -1.45 -2.2 -3.71 -4.93 -0.7 -0.77 -5.45 -4.76 -3.77 -1.45 -5.46 -1.11 -8 -0.28 -2.04 -5.14 -0.48 -2.13 -4.19 -0.52 -0.19 -3.37 -3.25 -0.16 -3.62 0.02 -0.31 -5.62 -3.93 -5.26 0.06 -0.51 -2.42 -0.48 -6.7 0.13 -2.85 -0.26 -0.95 -3.53 -1.79 -0.13 -0.36 -0.04 -0.94 -0.32 -0.32 -0.17 -0.58 -0.79 -0.2 -5.89 -0.12 -0.19 -0.14 -5.21 -0.31 -0.28 -0.17 0.1 -5.58 0.21 0.21 Pyroglutamic acid -0.33 0.04 -0.01 0.12 0.02 -0.29 -0.27 0.06 0.02 0.16 0.2 -0.28 -0.17 0.44 0.18 -0.08 -0.03 -0.05 0.08 -0.05 0.34 -0.17 -0.4 0.31 -0.06 -0.03 -0.86 -0.01 0.26 -0.64 -0.12 -0.1 -0.28 -0.78 -0.08 0.13 -0.11 0.23 -0.55 -0.35 0.36 -0.05 0.14 0.02 0.02 -0.22 -0.33 0.51 -0.32 -0.22 -0.07 0.01 -0.17 0.13 0.15 0.05 -0.34 0.21 0.02 0.02 -0.26 -0.16 0.27 0.08 -0.48 0.43 0.16 -0.21 -0.48 -0.4 -0.07 0.82 0.06 0.18 -0.42 -0.01 0.5 0.16 -0.19 -0.02 -0.46 0.01 -0.14 0.23 1 -0.04 0.01 0.18 -0.2 0.06 0.01 -0.03 0.43 0.07 -0.22 -0.11 0.05 0.38 0.11 -0.02 0.88 -0.15 0.06 0.06 -0.01 -0.05 -0.08 -0.41 0.21 -0.12 -0.01 -0.39 0.03 0.02 -0.12 -0.12 -0.27 -0.28 -0.08 0.07 -0.12 -0.29 0.18 -0.02 0.01 0 -0.28 0.09 -0.16 0.34 0.1 0.12 -0.24 -0.28 0.12 0.16 0.02 0.5 -0.05 0.02 0.08 -0.02 -0.44 0.23 0.01 0.33 0.17 -0.15 0.18 0.1 0.02 -0.01 0.26 -0.16 0.02 -0.44 0.14 -0.02 -0.12 0.33 0.51 0.07 0.03 -0.1 0.1 -0.32 0.51 0.06 -0.04 -0.38 -0.08 0.1 -0.77 -0.08 0.03 -0.33 0.08 -0.02 -0.04 -0.1 0.06 -0.16 -0.15 -0.21 0.1 -0.03 0.1 0.04 0.03 0.03 Pyrophosphate -0.53 0.75 -0.66 -0.27 -1.21 -5.65 -0.52 0.12 0.87 2.37 0.1 -1.67 0.58 -4.02 -0.02 1.78 -0.43 1.54 -2.22 -0.99 -1.58 1.23 1.22 -1.39 -1.38 -0.66 -0.65 -0.63 -0.03 0.45 -0.56 0.07 -0.25 0.1 -0.24 3.18 -1.05 -1.06 -0.63 -1.23 -0.16 -0.54 2.23 0.42 -1.49 -0.52 -0.67 0.42 -0.04 -0.17 0.96 -2.81 0.25 0.11 -0.38 -0.09 -0.26 0.13 -3.46 -1.68 -0.77 0.41 -0.41 -0.2 -0.2 -0.16 -0.07 -0.17 0.12 0.25 -0.48 -0.91 0.42 -0.83 -0.51 0.15 -2.59 -0.45 -0.22 0.59 -0.02 -0.12 -0.04 -1.19 -0.13 0.14 -0.3 1.57 -1.16 0.34 -0.21 0.92 1.45 -0.18 -0.04 -0.2 -0.54 0.14 -0.48 -0.36 -0.56 0.04 -0.13 -0.71 -1.61 -0.08 1.35 0.19 0.86 0.35 -0.78 0.77 0 -0.12 -0.89 -0.06 -0.05 0.02 -0.11 -0.06 -3.39 -1.27 0.12 0.05 -1.34 -0.86 0.39 0.12 0.54 0.31 -0.86 0.29 -0.64 -2.13 -1.68 -1.15 -0.49 -1.39 1.31 -0.72 0.08 -0.4 -1.34 0.12 0.06 -0.3 -0.26 -0.2 -0.32 0.68 0.02 -2.27 2.01 0.26 -3.78 -1.57 -0.06 1.58 -1.21 1.36 0.78 0.11 0.12 1.3 1.18 -0.83 -1.96 0.79 -0.57 -0.93 -0.21 0.16 0.24 2.16 -0.82 -1.74 -0.44 -0.55 -2.56 0.33 -0.08 -1.06 0 0.12 1.62 1.06 -0.84 -2.24 -0.05 -0.05 pyruvate -0.71 -0.22 0.24 0.12 -0.51 -1.72 -0.5 -0.06 -0.26 0.13 -0.16 -0.43 -0.39 0.1 0.76 -0.65 -0.99 -0.21 -0.25 -2.44 -1.67 -0.61 -1.15 0 -1.08 1.25 0.27 -0.17 -0.03 -0.2 0.15 0.1 -1.42 0.5 -0.06 0.66 -1.66 -2.01 0.47 -1.21 0.44 -0.24 0.91 0.16 0.23 -0.9 -0.24 -0.6 -0.68 -0.5 -0.26 -1.98 0.06 2.02 -0.13 0.09 -0.55 0.26 -0.94 -1.22 -0.07 -0.32 0.45 -0.18 -0.63 0.48 0.74 -0.4 -1.91 -0.61 -0.87 -1.3 -0.29 0.24 -0.76 -0.67 -1 0.18 -0.02 0.22 -1.49 1.96 -0.22 0.32 0.86 -0.96 0.45 0.46 -0.31 -0.04 0.41 -0.3 0.84 0.22 -0.1 -0.29 -0.55 -0.03 -0.19 -0.23 0.86 -0.18 0.12 -0.39 -1.53 -0.3 -0.56 -0.19 0.35 -0.3 -0.46 -0.45 0.17 -0.46 -1.11 -0.48 -1.16 -0.22 -0.18 0.04 -1.73 -1.94 -0.45 -0.71 -2.39 -0.58 -0.55 0.53 -0.22 0.93 -1.32 0.09 -0.1 -2.01 -1.07 -0.49 0.66 -0.73 0.25 -0.17 0.22 0.13 -1.85 0.67 0.42 -1.18 -0.3 1.43 0.27 -0.14 0.53 0.02 -0.34 -0.21 -1.33 -0.11 0 0 -0.24 0.43 0.58 -0.14 -0.22 -0.68 0.34 -0.21 0.79 0.14 -0.09 -0.28 1.61 -0.14 0.49 -0.07 0.1 -0.22 1.23 -0.22 -0.16 -0.01 -0.26 -0.63 -1.34 -0.21 0.14 -0.06 0.39 -1.56 0.18 0.18 ribose-phosphate 0.49 0.16 -0.07 -0.06 -0.06 -1.91 -1.24 0.24 0.13 0.12 0 -0.02 -0.08 -0.32 0.28 -1.25 0.44 0.51 0.38 0.22 -0.97 -0.26 -1.32 -0.36 0.04 0.75 0.49 -0.21 -0.01 -0.46 -0.21 0.32 -0.42 1.33 0.02 0.99 -0.62 -0.61 -0.05 -0.72 -0.38 -0.45 0.24 -0.31 -1.08 0.24 0.15 0.24 0.16 0.4 -1.01 0.03 0.14 0.62 -0.11 -1.01 -1.29 -0.06 -0.03 -0.18 0.17 0.34 0.64 -0.8 -1.38 0.15 0.35 -0.99 0.18 -0.12 -0.44 -0.6 0.33 -0.15 1.32 0.07 -0.95 -1.07 -0.15 -0.86 -0.08 0.43 -1.02 -0.25 0.23 0.36 -1.04 -1.57 -0.32 -0.15 0.19 -0.3 0.59 -0.97 -1.02 -0.13 0.27 -0.36 -0.67 0.15 -0.12 -0.14 -0.19 0.22 -0.82 0.07 0.69 -0.67 0.72 -0.3 0.04 1.01 -0.16 -0.29 -1.76 -0.09 0.03 0.2 -0.33 -0.36 -0.39 -1.65 -0.19 -0.48 -0.72 -0.16 -0.38 -0.43 -0.42 1.53 -0.35 -1.05 0.91 0.47 -0.1 -0.05 0.53 -1.45 0.09 -1.35 0.26 -0.01 -0.61 0.17 0.04 -0.4 -0.05 0.4 0.07 -0.13 0.86 -0.01 -0.37 -0.41 -0.25 0.26 0.53 0 0.69 1 -0.8 -0.66 0.49 0.58 -0.84 0.29 0.86 -0.58 0.61 0.51 0.62 0.21 1.37 -0.42 0.93 0.57 0.43 -0.06 0.44 0.36 -0.3 -0.17 -0.52 0.02 0.19 0.11 0.72 -0.19 -0.01 -0.01 S-adenosyl-L-homoCysteine 0.02 0.15 -0.24 -0.06 -0.24 -2.6 -0.19 -0.44 -0.13 -0.08 -0.21 -0.01 -0.28 -0.29 0.2 0.69 0.23 0.4 -0.22 0.25 -0.12 0.09 0.68 -0.1 -0.42 -0.63 0.99 0.38 0.17 0.13 0.06 -0.03 -0.24 0.24 -0.3 0.07 -0.01 -0.04 0.28 -0.13 -0.04 0.05 0.05 0.03 -3.53 -0.07 0.05 0.9 0.09 0.16 0.73 0.2 0.1 -0.39 -0.37 -1.83 -0.07 0.16 0.51 -0.08 -0.3 0.2 0.35 -0.6 0.02 0.66 0.54 -0.01 0.09 -0.38 -0.01 0.93 -0.24 0.05 0.01 1.34 -0.44 -0.56 0.03 -0.64 -0.11 0.08 -0.12 0.11 0.06 0.27 -0.69 0.32 0.12 0.05 0.06 -0.01 -0.28 -0.21 0.01 -0.16 1.21 0.17 -0.16 -0.13 -0.08 -0.34 -0.02 0.06 0.75 0.04 -0.13 0.05 -0.35 -0.37 0.63 -0.25 0.1 1.55 -0.39 -0.16 0.01 0.14 -0.04 -0.12 0.15 -0.19 -0.33 0.04 -0.25 0.62 0.25 0.13 0.23 -0.05 -0.1 -0.58 -0.01 -0.25 0.1 -1.2 0.19 0.03 -0.09 -1.31 0.06 0.06 -0.33 0.25 -1.19 0.23 -0.03 0.06 0.08 -0.02 0.07 0.02 -0.66 0.09 -0.18 -0.07 0.29 -0.03 0.21 -0.17 0.2 -0.22 0.14 2.16 -0.63 0.1 -0.3 -0.11 -0.11 0.05 -0.08 0.08 0.23 0.02 -0.2 -0.16 0.06 0.09 0.02 0.27 -0.04 0.07 0.38 0.4 -0.44 0.12 0.08 0.35 0 0 S-methyl-5--thioadenosine 0.29 0.1 0.21 -0.08 0.34 -3.42 -0.43 0.19 0.04 0.19 0.28 0.79 0.57 -0.15 0.51 -0.97 0.14 0.99 -0.41 0.61 0.14 0.87 -0.93 0.88 0.13 -0.13 0.49 1.54 0.74 -0.01 0.29 0.01 0.19 -5.43 -0.26 0.42 0.35 0.03 1.52 -0.11 0.09 1.28 0.8 0.01 0.4 0.03 -0.85 0.32 -3.6 1.64 -1.11 1.54 -0.27 -0.75 0.83 -0.04 0.26 0.03 0.47 0.36 0.07 0.37 0.4 0.68 0.29 1.13 0.49 0.79 0 -3.43 -0.19 1.76 0.87 0.59 0.94 0.76 0.09 0.49 -0.3 -0.43 0.3 -1.49 1.23 0.08 -0.16 1.38 -0.41 -0.91 -0.19 -0.24 0.01 0.92 -0.37 0.09 0.44 -2 0.86 -0.29 1.35 0.39 -0.25 -0.3 0.02 0.57 0.13 -1.69 -0.03 0.6 -0.07 -0.02 0.71 -0.5 0.15 0.94 0.87 0.27 0.24 -0.4 -0.33 -0.21 -0.09 1.13 -0.33 0.64 -0.13 1.03 0.43 -0.12 0.32 0.01 0.87 -0.48 0.17 0.57 0.69 0.87 0.49 0.5 -0.26 -0.46 -0.12 0.08 -0.01 0.3 0.4 1.21 0.58 -0.78 0.33 0.6 -0.06 1.53 -0.09 0.56 0.11 0.63 0.67 0.22 -0.24 0.06 0.66 0.82 0.45 1.59 -0.01 0.07 0.08 0.27 -0.1 -0.18 -1.11 0.13 -1.25 0.02 -0.04 -0.59 -0.45 0.54 1.83 0.22 0.43 0.67 0.14 0.34 0.24 0 0.06 0.32 0.14 0.14 sarcosine/alanine 0.23 -0.09 -0.52 -0.03 0.28 -3.77 -0.52 -0.98 -0.25 -0.06 -0.76 -0.97 -0.96 -1.43 -0.51 -0.3 0.12 -1.42 0.8 -2.62 -1.68 -0.75 -0.98 -2.39 -4.6 1.02 -0.43 -1.61 -0.33 0.16 -0.47 0.02 -0.81 -0.45 -0.28 -0.3 -1.71 -1.58 -0.73 -0.02 -0.5 -1.14 -0.56 -0.17 -1.65 0.14 0.16 -0.04 -0.38 -0.88 0.4 -2.17 -0.24 0.44 -0.2 -0.85 -0.03 0.35 -1.34 -1.27 -0.6 0.05 -0.4 -0.77 0.74 -0.38 -0.09 -0.42 -0.44 0.28 -0.28 -1.21 -1.38 -1.63 -0.22 0.45 -2.96 -1.33 0.01 -0.67 -0.64 -0.43 -1.11 -0.76 0.2 -0.35 -0.35 -0.55 -0.32 -0.97 -0.59 -0.5 -0.38 -0.27 -0.08 1.09 0 0.35 -0.55 -0.52 0.06 -0.25 1.34 -1.75 -1.41 -0.2 -0.12 0.34 0.46 -1.27 0.72 0.31 -0.48 -1.28 -1.22 -0.53 -0.52 -0.17 -0.17 0.24 -1.94 -1.14 -0.39 0.15 -1.66 -0.84 -0.55 -0.47 -0.87 -1.33 -1.16 -0.57 -0.42 -2.23 -2.06 -2.02 -0.72 -1.52 -0.17 -3.02 0.14 0.3 -1.67 -0.37 -0.46 -1.14 -0.35 -0.06 -0.38 -0.79 -0.13 -1.04 -0.51 0.29 -2.16 -1.11 -2.28 0.12 -0.51 -0.42 0.2 -1.67 0.08 -0.21 -0.15 -0.32 -1.57 -0.63 -0.76 -0.24 -0.3 0.04 -0.78 -0.18 -0.03 -0.2 -0.49 -0.4 -1.44 0.43 -0.19 0.04 -0.99 0.24 0.2 0.26 0.48 -2.76 0.25 0.25 SD 0.25 -0.03 -2.29 -0.14 -0.62 -3.62 -0.87 -0.22 -0.34 -0.11 -1.22 -1.17 -1.91 -2.77 0.14 -0.23 0.06 -2.31 -1.64 -1.49 -2.16 -2.21 -1.04 -0.54 -2.81 -0.95 -1.15 -1.43 -0.74 1 -0.73 -0.24 0.33 -0.3 -0.08 0.54 -1.63 -2.26 -2.26 -0.01 -0.07 -0.27 -0.88 -0.41 -0.23 0.28 -0.38 0.15 0.19 -1.43 -0.48 -1.51 -1.78 0.3 -0.36 -0.37 -1.87 -0.53 -2.44 -1.13 -0.86 0.63 0.1 0.81 -0.77 -2.7 -0.79 -3.36 0.4 -0.72 -0.26 -1.06 -2.47 -1.58 0.1 -0.53 -1.65 -1.51 0.01 -0.91 -0.48 0.36 -2.25 -0.96 -0.01 -2.07 -0.69 -1.28 0.02 -1.74 0.38 -0.06 -1.59 -0.82 -0.88 0.42 -0.55 0.06 -1.06 0.26 -0.72 -1.16 -0.33 -2.42 -1.32 -0.16 -0.24 -0.84 -0.42 -2.11 1.14 0.24 -1.71 -0.41 -1.94 -0.92 -0.08 -0.75 -0.11 -0.46 -1.16 -3.09 -0.66 -0.82 -1.24 0.01 -1.37 -2.5 -1.61 -1.07 -1.39 -1.19 -0.43 -1.76 -1.46 -1.73 -0.38 -1.61 -0.36 -2.26 -0.22 -0.26 -1.71 -0.05 -0.94 -1.55 0.66 0.81 -1.1 -0.24 -0.02 -1.73 -0.09 0.22 -1.93 -1.7 -3.9 -0.25 0.22 -1.37 0.34 -2.86 0.35 -1.51 -1.07 0.05 -2.03 0.15 0.17 0.22 0.83 0.42 -0.61 -0.4 -0.08 -0.03 0.93 0.02 -1.88 0.39 0.06 0.49 -2.3 -0.08 -0.22 -0.21 0.04 -2.74 -0.07 -0.07 Sedoheptoluse bisphosphate 0.15 0.08 0.54 0 -0.03 -3.05 -0.22 0.11 0.11 0.01 -0.55 -0.27 0.07 0.24 0.27 -0.21 -0.09 0.09 0.19 -0.88 -1.1 -0.08 -0.7 -0.79 -0.13 0.47 0.67 -0.28 -0.16 -0.1 -0.19 -0.06 1.5 0.14 -0.14 -0.26 -0.79 -0.97 0.23 -0.19 -0.24 -0.16 -0.27 -0.25 -0.21 0.02 0.01 0.05 0.18 -0.11 -0.15 -1.84 -0.01 0.58 0.07 -0.01 -0.24 -0.11 0.03 -1.12 -0.23 0.74 -0.4 -0.21 -0.17 0.37 0.45 -0.26 -0.2 0.09 -0.42 -0.29 -0.08 -0.19 -0.27 0.01 -1.73 -0.32 -0.08 -0.15 -0.18 -0.08 -0.13 -0.42 -0.03 -0.06 -0.28 -0.34 -0.15 -0.26 -0.16 -0.26 -0.13 -0.32 -0.06 0.08 0.07 0.06 -0.02 -0.06 -0.28 0.04 -0.34 -0.07 -0.78 0.01 -0.36 -0.02 0.12 -0.6 0.28 -0.17 -0.4 0.07 -0.97 0.03 -0.21 -0.18 0.11 -0.38 -0.96 -0.89 -0.36 0.06 -0.68 -0.23 -0.24 -0.57 0.16 -0.15 -1.56 -0.59 -0.27 -2.68 -0.86 -0.83 -0.29 -0.97 0.05 -1.54 0.07 0.17 -0.93 -0.18 -0.08 -1.14 -0.42 -0.02 0.58 -0.38 -0.06 -0.02 -0.29 0.57 -2.8 -0.14 -0.18 -0.02 -0.84 0.07 0.63 -0.14 -0.08 0.61 -0.3 0.41 -0.08 0 -0.3 -0.06 -0.18 0.12 -0.09 0.07 -0.35 -0.41 -0.28 -0.19 -0.08 0.38 -0.28 0.14 -1.14 0.05 0 0.05 0.2 -0.93 0.08 0.08 sn-glycerol-3-phosphate 0.72 0.44 -0.12 -0.42 0.15 -0.82 -1.08 0.27 0.14 -0.03 -0.04 0.29 0.49 0.46 -0.31 0.77 0.77 0.64 -0.22 1.54 0.82 0.87 0.92 -0.31 0.09 0.16 0.02 -0.03 0.37 -0.08 -0.36 0.3 -0.24 0.69 -0.66 -0.32 0.33 1.27 -0.36 -0.38 -0.1 0.02 -0.22 -0.25 0.17 0.29 -0.14 0.11 0.34 0.51 0.91 0.52 0.02 0.28 0.12 0.01 -0.39 0.24 -0.09 0.76 -0.03 -0.31 0.18 -0.23 -0.59 0.33 0.53 -0.37 -0.31 0 -0.23 0.66 0.27 0.27 0.81 0.1 0.02 -0.7 -0.15 -0.06 -0.03 0.17 -0.48 -0.23 0.02 0.57 -0.42 0.8 0.24 0.18 -0.29 1.38 -0.94 -0.23 -0.42 0.3 0.05 0.41 -0.42 -0.14 -0.08 -0.28 -0.04 -0.03 0.35 0.43 0.2 -0.51 -0.24 0.88 0.2 -0.46 -0.41 0.14 -0.59 -0.02 -0.07 0.25 -0.22 -0.08 0.18 -0.4 0.14 -0.14 0.63 0.03 -0.13 0 1.01 -0.17 2.05 -0.59 1.23 1.06 0.87 0.39 0.04 0.53 0.63 -0.08 0.27 -0.4 0.03 -0.2 -0.35 1.63 0.19 0.04 0.87 0.65 0.11 -0.32 -0.28 -0.16 -0.66 0.43 0.56 0.56 -0.78 0.03 -0.26 -0.36 0.89 0.73 -0.64 0.35 -0.42 0.56 0.15 0.42 -0.05 0.88 0.76 0.17 -0.23 0.47 0.03 -0.13 0.26 0.62 -0.48 0.5 0.69 0.16 0.13 0.24 0.15 1.33 -0.02 -0.02 succinate/methylmalonic acid -0.27 -0.22 -0.27 -0.23 -0.27 0.47 -0.32 -0.05 -0.27 -0.04 0.32 -0.54 -0.9 -0.01 -0.02 -0.14 -0.82 0.27 -0.32 0.79 0.3 -0.53 -1.23 -0.21 -0.94 -0.23 -0.4 -0.18 0.6 0.01 -0.38 0.29 -0.21 -0.51 -0.75 -0.22 0.04 0.26 -0.75 -0.5 0.15 -1.02 -0.28 -0.13 0.1 0.01 -0.21 0.08 -0.53 -1.22 -0.29 0.46 0.15 -0.36 -0.51 0.09 -0.21 0.04 -1.66 0.3 -0.4 0.03 0.01 -0.42 -0.27 -0.27 -0.07 0.34 -0.52 0.03 -0.35 -0.14 -0.44 0.15 -0.52 -0.38 0.44 -0.18 0.21 -0.25 -0.43 -1.65 -0.59 -0.58 0.1 -1.08 0.1 0.24 0.19 0.13 -0.51 -0.3 0.34 -0.19 -0.37 0.56 -0.78 0 0.45 -0.02 -0.07 -0.13 0.19 -0.47 0.24 0.19 0.38 -2.08 0.72 -0.79 -0.48 0.8 -0.4 -0.33 -0.13 -0.66 -0.43 0.38 -0.02 0.57 -0.06 -0.29 0.78 0.37 -0.18 -0.5 0 0.26 0.03 0.39 0.57 0.25 0.04 0.45 0.87 0.48 0.3 0.16 -0.28 -0.58 -1.09 0.15 0.36 -0.51 -1.28 0.26 -0.13 -0.42 -0.08 -0.18 0.03 -0.14 -0.27 -0.16 0.22 -0.39 -0.72 -1.49 0.1 0.09 0.46 -0.49 0.12 -0.01 -1.22 -0.07 -0.08 0.07 0.2 -0.74 0.1 -0.42 0.18 0.07 -0.38 0.25 0.14 0.14 -1.09 0.36 -0.02 0.23 -0.05 -0.36 -0.11 -0.03 0.08 0.3 0.07 0.07 thymidine -0.17 -0.31 0 0.18 0 0 0 0 0 0 1.25 -0.8 -1.38 -1.59 -0.58 0.01 0 -5.82 -0.5 -0.84 1.42 -4.24 -3.53 0.34 -0.88 -0.36 -1.83 -0.71 -0.71 -0.57 0.05 0.15 -0.29 -0.53 0 0.26 2.52 1.36 -0.54 -1.05 1.24 -0.47 0.19 -2.52 -1.89 -1.14 0 -0.52 -0.48 0 -1.1 0.3 -0.74 -0.94 -0.46 -1.36 0.27 0.19 -0.01 1.15 0.19 3.25 -1.56 -0.24 1.75 -1.19 0.85 -2.39 0.12 1.5 -1.42 2.7 -1.09 -0.61 -0.78 -0.09 -1.77 -0.12 0 -0.08 -0.3 -0.53 1.66 -1.65 -1.18 -0.57 0.1 0.08 4.18 -1.68 0.05 -0.54 -0.37 1.57 2.93 -1 0.34 0.12 0.92 -2.08 -0.1 2.11 -0.32 0.37 2.19 -1.21 -0.03 2.5 0.09 -1.07 0.68 -2.35 0 0.16 2.57 -0.92 -2.23 -0.3 0 0.1 1.83 -1.28 0.21 0.71 2.07 0.07 1.29 -2.07 -0.56 0 0.78 0.07 -0.5 0.51 -1.58 -0.3 -0.71 1.09 -0.26 -0.58 -0.81 0 0 -1.33 1.28 1.06 -0.31 -0.82 -0.56 -1.94 -0.73 -0.71 -0.02 3.89 -0.39 -0.2 0 -1.23 -1.81 -0.92 -0.16 -0.8 0.06 3.55 0.2 0.23 -0.52 -0.93 -0.64 -0.16 -0.5 -1.24 -3.8 -0.86 -0.01 -1.38 -0.88 -0.28 -1.49 -0.42 -0.71 -0.65 0 0 0 0 0 0 1.03 1.03 thymine -0.82 0.25 0 0.38 0 0.27 -0.34 0 0 0 0.05 -0.38 -0.81 0.16 -0.18 0.03 -0.23 -0.04 0.06 -0.54 0.12 -2.12 -2.14 -1.03 -0.09 -0.18 3.39 -0.04 -0.31 -0.42 0.08 0.08 -0.12 -0.13 -0.48 0.29 -0.85 0.09 3.42 -2.68 -0.88 -0.01 0.15 -0.31 0.86 -2.04 -0.04 1.76 0.1 -1.46 -0.22 -0.56 -0.38 0.33 0.04 0.46 -0.49 -0.34 -0.2 -0.56 -2.16 -0.22 -0.39 0.37 -0.56 3.15 1.53 -0.22 -0.07 0.21 -0.24 4.43 -0.13 -0.47 -1.12 -0.49 -1.7 0 -0.06 0.02 -0.01 0.11 -0.11 -1.59 0.19 -0.25 0.93 0.65 0.3 -1.34 -0.29 -0.59 -0.01 0.37 -0.05 0.11 -0.4 -0.11 0.19 -0.23 0.29 -0.47 -0.01 -0.09 -0.25 -0.04 -0.03 -0.67 0.31 -0.46 -0.76 -1.15 0 -0.42 -0.2 -0.2 -0.07 -0.03 -0.08 0.34 -0.2 -0.51 0.43 0.1 -0.05 -0.84 0.88 -0.82 -0.13 0.35 0.18 0.88 -0.7 -0.84 -1.91 -0.32 -0.53 0.47 0.11 -0.02 -0.08 -0.24 0.31 -0.5 0 0.4 0.33 0.05 -0.11 -0.41 -0.03 -0.16 0.2 -0.28 -0.15 -0.87 0.29 -0.08 -0.5 0.03 0.35 0.03 0.01 -0.75 0.44 -0.55 0.03 -0.42 0.03 -0.67 0.16 0.17 -0.01 0.22 0.12 0.15 0.22 -0.06 -0.39 0.48 -0.26 -0.57 0 0 0 0 0.58 0 -0.28 -0.28 UDP -1.02 -0.9 -0.07 0.07 0.15 -1.54 -2.04 -1.36 -1.4 0.31 -0.88 -0.05 -0.54 -0.79 0.16 -0.4 -1.39 -0.62 -0.46 -0.51 -1.28 -0.3 -0.69 -0.52 -0.98 -0.71 0.7 -0.3 -0.41 1.27 0.39 -0.21 -0.01 -0.77 -0.23 -0.03 0.31 -1.22 0.85 0.15 -0.22 0.49 -0.19 0.04 -1.86 -1.39 -1.45 -1.17 -0.68 0.1 -1.69 -0.27 -1.11 -2.08 -0.37 -1.46 -0.49 -0.44 -0.52 -0.71 -0.68 0.72 -0.7 0.04 -0.35 1.21 0.49 0.2 -1.36 -1 -1.4 1.17 -0.49 -0.57 -0.33 -1.03 -1.45 0.57 0.07 -0.38 -0.53 -0.34 -0.11 -0.24 -2.47 -0.36 -0.08 -0.12 -0.62 -1.32 -0.12 0.47 0.16 0.88 0.39 -1.2 0.08 0.2 0.88 -0.57 -0.13 0.66 -0.14 0.08 -0.45 -1.21 -0.1 0.16 -0.02 -0.54 0.15 -0.98 0.23 -0.54 -1.05 -0.24 -0.33 0.05 0.1 -0.29 -0.48 -0.28 -0.07 0.27 -0.24 0.23 0.77 0.17 -0.27 -0.47 -0.35 0.23 -0.3 -0.31 -0.69 -0.53 -0.1 0.06 -0.22 -0.87 -1.83 -1.8 -0.14 0.12 0.32 -0.11 -0.62 -0.36 0.17 0.22 -0.21 -0.66 0.12 0.18 -0.42 -0.39 -0.33 -1.77 -0.65 -1.89 0.46 0.36 0.49 -0.17 -0.01 0.02 -0.57 0.28 0.12 -0.37 0.07 -1.42 0.33 -1.03 -0.16 -2.15 -0.66 0.28 -0.23 -0.87 0.02 -1.52 -0.58 0.11 0.21 0.4 0.27 -0.73 0.22 0.22 UDP-D-glucose -0.03 -0.03 0.09 -0.07 0.13 0.06 -0.3 0 -0.11 -0.04 -0.18 -0.06 0.03 -0.02 0.05 -0.13 0.17 0.27 0 0.21 -0.06 0.02 -0.28 0.07 0.08 -0.05 0.15 -0.08 0.02 0.16 0.03 0.02 -0.03 0.18 -0.16 0.02 0.21 -0.08 0.16 -0.33 -0.03 -0.1 -0.06 0.02 -0.06 -0.09 -0.04 0.04 0.04 0.32 -0.18 0.17 0.06 -0.2 0 0 -0.07 -0.01 0.05 0 -0.11 0.23 0.08 0 -0.09 0.14 0.29 -0.02 0.07 0.01 -0.3 0.28 0 0.21 -0.02 -0.24 0.04 -0.03 0.06 -0.25 -0.01 0.14 0.04 0.1 0.07 0.01 -0.26 -0.03 0.12 -0.02 -0.07 -0.04 -0.09 -0.13 -0.03 -0.07 -0.04 0.05 -0.03 -0.01 -0.04 -0.08 -0.09 0.02 -0.17 0.07 -0.14 0.04 -0.05 -0.35 0.15 -0.56 -0.06 -0.04 -0.01 -0.01 0.05 0.05 0.04 0.05 -0.19 0.02 -0.03 0.08 -0.13 0.03 0.15 0.17 0.14 0.09 -0.07 -0.24 -0.05 -0.28 -0.02 -0.05 0.05 0.3 -0.08 0.03 -0.21 -0.02 -0.03 0.06 -0.03 0.25 0.09 0.1 0.18 0.1 0.05 0.14 -0.27 0.17 -0.09 -0.11 0.14 -0.14 0.08 -0.07 0.5 0.12 0.01 0.29 -0.18 0.06 -0.05 0.02 -0.07 -0.1 0.14 0.08 0.2 -0.08 -0.19 -0.29 0.05 0.05 0.24 0.36 -0.06 0.11 -0.16 0.09 -0.07 0.03 0.14 -0.16 0.05 0.05 UDP-D-glucuronate -0.17 -0.13 -0.07 0.05 0.24 -0.16 -0.22 0.01 -0.03 0.61 -0.18 -0.29 0.01 -0.02 -0.13 -0.02 -0.13 -0.11 -0.14 -0.09 -0.01 0.09 -0.51 -0.11 -0.11 0.01 0.11 -0.24 -0.03 0.09 0.17 0.02 -0.04 -0.05 -0.16 -0.02 -0.11 0 -0.08 -0.7 0.03 -0.24 -0.06 0.03 0.12 -0.27 -0.61 0.18 -0.09 -0.05 -0.24 -0.12 -0.14 -0.2 -0.1 0.21 -0.35 0.11 0.02 -0.33 -0.13 0.25 -0.07 0 -0.32 0.22 0.26 -0.06 -0.02 -0.02 -0.27 0.32 0 0.15 -0.3 -0.23 -0.43 -0.03 -0.14 -0.34 0.14 0.09 -0.06 0.3 -0.18 -0.1 -0.3 0.05 -0.07 -0.13 -0.12 -0.1 -0.13 -0.2 -0.2 -0.12 -0.05 -0.03 -0.33 -0.17 -0.24 -0.11 -0.24 -0.16 -0.08 -0.02 -0.13 -0.21 -0.07 -0.42 0.08 -0.7 -0.26 -0.06 -0.4 -0.08 0.16 -0.05 -0.19 0.02 -0.16 -0.3 -0.03 -0.13 -0.38 -0.13 0.12 0.24 0.11 0.03 -0.23 -0.41 -0.26 -0.52 -0.24 -0.15 -0.14 0.38 0.02 -0.17 -0.11 -0.48 -0.61 0.02 -0.01 0.35 0.1 0 0.28 -0.15 -0.12 -0.07 -0.19 0.19 -0.21 -0.32 0.02 -0.15 -0.07 -0.06 0.5 0.11 0.18 -0.19 -0.21 -0.06 -0.02 -0.22 -0.16 -0.24 -0.01 0.05 0.12 -0.31 -0.2 -0.35 -0.12 -0.08 -0.11 0.4 -0.07 -0.13 -0.84 -0.14 0.61 0.41 0.03 -0.24 0.01 0.01 UDP-N-acetyl-glucosamine -0.15 -0.18 0.04 -0.09 0.34 -0.11 -0.47 -0.16 -0.26 0.06 -0.22 -0.16 -0.11 -0.13 0 -0.14 0.08 0.53 0.01 0.61 0.09 -0.14 -0.42 -0.21 -0.14 0.01 0.4 -0.1 -0.03 0.21 0.08 -0.01 -0.13 0.09 -0.23 -0.1 0.36 0.07 0.35 -0.46 -0.2 0.04 -0.07 -0.01 -0.28 -0.33 -0.3 -0.1 -0.08 0.58 -0.42 0.29 -0.14 -0.29 -0.06 -0.31 -0.05 0 0.01 -0.01 -0.07 0.26 -0.07 0 -0.06 0.53 0.38 0.06 -0.11 -0.16 -0.51 0.44 -0.09 -0.1 0.06 -0.35 -0.24 0.09 0.07 -0.26 -0.1 0.1 0.05 -0.02 -0.27 0.17 -0.24 -0.09 -0.03 -0.24 -0.12 0.04 -0.09 -0.1 0.08 -0.3 -0.02 0.09 0.05 -0.07 -0.05 -0.1 -0.13 -0.06 0.03 -0.11 -0.14 0.16 -0.06 -0.37 0.18 -0.47 0.1 -0.05 0 0.02 -0.05 0.01 0.02 0.03 -0.01 0.22 -0.04 0.12 -0.03 -0.04 0.36 0.04 0.15 -0.09 0.09 -0.24 -0.01 -0.17 0.04 -0.15 0.01 0.46 -0.07 -0.16 -0.45 -0.28 0.08 0.02 0.03 0.39 0.12 0.04 0.2 -0.01 -0.08 0.16 -0.32 0.21 0.08 -0.18 0.05 -0.46 0.11 -0.31 0.63 -0.04 0.07 0.65 -0.2 0.04 -0.22 0.07 -0.06 -0.2 0.15 -0.14 0.11 -0.38 -0.28 -0.55 -0.03 0.05 0.16 0.32 -0.08 -0.08 0.08 0.16 0.07 0.14 0.15 0.19 0.06 0.06 UMP -0.56 -0.79 0.18 -0.45 0.3 -1.26 -2.06 -1.09 -1.04 -0.19 -0.37 -0.49 -0.86 -0.11 -0.12 -0.19 -1.42 -1.52 -0.6 0.06 -0.62 -0.7 -0.66 -0.21 -0.12 -0.62 -0.21 -0.38 -0.32 -0.22 0.06 0.28 -0.17 -0.5 -0.32 -0.4 0.33 -0.63 -0.52 0.12 -0.2 0.21 -0.31 0 -1.47 -0.9 -1.3 -0.77 -0.7 -0.66 -1.32 -0.16 -0.9 -0.88 -0.19 -1.32 -1.64 -0.75 -1.1 -0.17 -0.34 -0.14 -0.33 -0.17 -1.52 0.03 0.46 -0.13 -1.67 -0.79 -1.28 0.2 -0.65 -0.51 -0.01 -0.62 -0.11 0.14 0.45 -0.42 -0.14 -0.02 -1.5 -0.37 -0.64 -0.05 -0.38 0.01 -0.57 -1.05 -0.26 0.39 0.15 -0.6 -0.62 -1.11 0.22 0.22 0.53 -0.56 -0.05 0.21 0.35 0.16 -0.05 -0.61 0.82 -0.5 0.47 0.43 0.1 -1.06 0.53 -0.59 -1.42 -0.05 -1.31 0.29 -0.19 0.01 -0.1 -1.2 1.09 -0.01 -0.28 0.47 0.76 0.11 -0.29 -0.59 0.07 0.02 0.11 -0.05 -0.5 -0.37 -0.13 -0.57 0.02 -0.61 -1.1 -3.16 0.12 -0.19 0.32 -0.48 0.23 -0.45 0.3 -0.91 -0.43 -0.35 -0.73 -0.63 -0.67 -0.79 -0.3 -1.11 1.15 -1.03 0.16 -0.63 1 -0.11 -0.27 0.04 -0.44 0.34 0.26 -0.04 0.17 -0.76 0.41 -1.44 -0.39 -0.98 0.03 -0.05 -0.88 -0.73 -0.19 -0.44 -0.39 -0.15 -0.09 0.18 0.11 -0.48 0 0 uridine -0.7 -0.25 0.28 0.2 0.44 3.3 -2.11 -0.34 -0.17 -0.03 1.26 -0.96 -0.54 -0.35 1.48 -0.01 -0.45 -0.56 0.47 -0.79 1.71 -0.2 -0.55 -0.14 0.02 -0.14 0.35 -0.22 0.4 0.09 0.01 -0.44 -1 -1.72 -0.02 0.3 -0.5 1.46 0.23 -0.64 0.6 -0.22 0.46 0.72 0.22 -0.48 -0.81 -1.18 -1.06 -0.58 -0.38 -1.08 -0.08 -0.24 -0.15 0.47 -0.29 0.4 -2.35 1.78 0.09 -0.07 0.7 0.21 0 0.52 0.59 -0.17 -1.38 -0.9 -1.62 0.08 0.05 -0.31 -0.55 -0.47 -0.58 1.05 0.05 0.38 -1.13 0.6 -0.47 1.2 0.32 0.41 0.69 0.38 -0.04 0.34 0.09 1.23 0.99 0.09 -0.03 0.21 -0.15 0.14 -0.28 -0.39 0.78 0.15 0.03 -0.03 -0.56 -0.84 -0.12 -0.19 0.1 -0.33 -0.43 -0.65 0.3 -0.52 -0.68 -0.15 -0.88 -0.5 -0.05 0.41 -0.78 -1.03 0.19 0.53 0.77 -0.47 -0.38 0.33 -0.23 0.27 -1.47 0.39 -0.49 -1.33 1.73 -0.17 0.38 0.05 -0.19 -1.59 -0.86 -0.61 0.52 0.67 2.91 -0.39 0.6 -0.26 0.4 -0.12 0.13 -0.44 -0.21 -0.17 -0.02 -1.17 -0.29 -0.11 0.19 -0.33 0.94 -0.35 0.18 -0.78 0.51 -0.58 0.25 0.73 0.05 -0.47 0.03 -0.12 -1.2 0.01 -0.28 -0.85 0.03 0.09 -0.93 -0.18 0.23 -0.62 -0.13 -0.06 0.03 -0.09 0.39 -0.19 0.18 0.18 UTP -1.2 -1.14 0 0.58 0 -6.79 -4.39 0 0 0 -0.95 -1.14 0 -0.19 0.14 -0.01 -3.97 -0.53 -0.22 -1.47 -1.31 0.17 -0.66 -0.32 -0.48 -0.01 -0.54 -0.52 0.12 0.21 -0.15 -0.31 -0.42 -1.42 0.05 -0.15 -0.84 -1.3 -1.89 -0.8 -0.04 -0.24 -0.15 0.14 -1.49 -1.05 -2.16 -0.93 -1.44 -1.9 -1.26 -1.94 -0.92 -0.53 -0.03 -0.97 -0.86 0.02 -0.36 -1.5 -0.07 0.46 -0.49 0.05 -0.64 0.58 0.41 -0.13 -1.64 -1.31 -1.13 0.77 -0.05 -0.17 -0.54 -1.47 -1.85 -0.04 -0.21 -0.31 -0.19 0.32 -0.15 0.24 -1.94 0.04 -0.19 0.1 -0.68 -1.03 -0.3 -0.1 -0.32 -0.21 -0.22 -1.42 -0.17 0.02 -0.95 -0.32 -0.48 0.18 -0.14 -0.6 -1.65 -2 -0.19 -0.11 -0.06 -0.61 0.17 -0.92 0 -0.24 -0.99 -0.13 -0.14 0.41 -0.37 0 -1.54 -1 -0.06 -0.07 -1.21 -0.42 0.02 0.21 0.01 -0.4 -0.86 -0.42 -0.19 -1.52 -1.52 -0.74 0.2 -0.21 0.26 -0.97 -1.7 -2.14 -1.55 0.3 -0.09 -1.52 0.36 0.43 0.51 -0.22 -0.48 -0.49 -0.06 0.3 -1.13 -1.06 -1.66 -1.67 -0.46 -1.79 0.47 -0.13 -0.34 -0.18 -0.08 -0.37 -0.3 -0.19 -0.3 -0.38 0.42 -0.6 0.63 -1.58 -0.17 -2.41 0.32 0.01 -0.68 -0.63 0.12 -1.46 0 0 0 0 -0.31 0 -0.42 -0.42 VD 0.59 0.11 -1.44 0.07 -1.24 -2.18 -0.44 1.59 -0.58 -0.08 -1.2 -1.05 -2.24 -2.22 0.67 0.11 0.34 -1.27 2.03 -0.87 -3.61 -1.11 -0.96 0.53 -2.44 -1.02 -1.16 -0.31 -0.91 1.24 -0.99 0.16 0.89 1.46 -0.6 0.92 -3.82 -3.34 -2.83 0.7 1.34 0.77 -1.09 0.15 -1.02 0.69 -0.11 0.14 1.06 -0.83 -0.04 -1.84 -0.88 0.91 1.2 -1.13 -0.57 -0.43 -2.5 0.71 -0.9 0.43 0.11 1.38 0.36 1.38 0.88 -1.84 0.3 -0.25 -0.22 0 -3.03 -0.57 0 -0.02 0.86 -1.43 -0.12 -0.13 -0.33 0.71 0.72 -0.48 -0.13 -2.46 -0.01 -1.57 1.89 -1.79 0.42 -0.27 0.91 0.06 0.84 1.03 1.88 0 -0.64 -1.05 -0.43 -0.21 -0.13 -2.99 -0.98 0.78 -0.65 0.37 -0.7 -2.79 2.83 0.31 -1.83 1.09 1 -0.38 0.1 0.87 0.4 -0.49 -1.25 -1.57 -0.87 -0.23 -0.36 2.34 -0.92 -1.5 -2.12 0.15 -1.89 -0.94 -0.59 -2.43 0.43 -0.15 -0.05 -2.04 0.06 -1.53 -0.08 0.4 -1.73 0.01 -1.86 -1.62 -0.68 0.52 0 0.36 0.06 -1.79 -0.38 -0.22 -2.4 -2.08 -2.53 -0.58 -0.67 -2.02 0.91 -3.63 0.29 -0.05 -0.41 0.22 -0.5 -0.02 -0.21 0.08 0.74 0.25 0.93 -0.1 -0.01 -0.16 -0.5 1.11 -2.23 0.45 0.01 0.62 -1.33 -0.08 0.21 -0.21 0.01 -2.73 0.06 0.06 xanthine -0.45 0.19 0.24 0.57 0.04 5.62 0.24 0.07 0.09 -0.32 0.75 -0.58 -0.65 0.27 0.54 0.22 0.11 -0.19 -0.16 0.18 1.42 0.63 0.37 -2.17 0.03 -0.23 0.52 -0.49 0.46 0.38 -0.14 -0.03 0.05 -1.6 -0.2 0.26 0.41 1.07 2.3 -0.28 -2.07 -0.68 0.54 -0.58 2.38 -0.03 -0.18 -0.14 -0.37 -0.51 0.15 -1.06 -1.5 -0.08 2.41 0.5 0.33 0.47 -0.48 0.92 0.2 0.24 0.8 0.58 0.16 1.24 0.95 0.83 -0.32 -0.63 -0.36 1.48 2.64 -2.5 -0.71 -0.55 -1.25 0.71 -0.02 -0.06 -0.22 -0.2 0.23 -2.11 0.83 2.15 0.74 0.93 -2.26 -1.93 0.56 0.72 0.59 -0.52 0.11 -0.15 -0.26 3.12 -0.79 0.36 0.87 0.06 0.23 -0.22 -0.1 0.64 -0.43 -0.41 -0.41 -0.59 -0.29 -0.82 0.39 -0.32 1.08 0.36 0.2 -0.05 -0.07 0.14 -0.08 0.53 -0.28 0.08 0.19 -0.64 -0.94 -2.04 0.64 0.16 -1.29 -0.34 -0.59 -1.12 0.9 0.34 0.25 0.9 0 -0.68 1.4 0.75 -0.17 0.43 0.17 -0.02 -0.27 -0.75 0.26 0.36 0.09 -0.39 0.1 1.79 -0.83 -0.7 -0.4 -0.17 -0.9 0.8 0.79 -0.93 -0.11 -0.78 -0.44 -0.03 0.77 1.56 -0.1 -0.01 -0.32 0.12 -1.61 -0.77 -0.47 -0.63 -0.38 0.08 -1.06 0.17 0.25 -0.09 0.3 0.07 -0.01 0.11 0.13 0.68 -0.09 -0.09 xanthosine -0.48 0.34 -1.05 4.51 0.34 -0.5 -0.66 -0.01 -0.41 -0.66 -0.32 -1.03 -0.56 -0.13 -1.26 0.87 -0.4 -0.12 -1.82 -0.58 -1.38 -0.11 -0.17 -0.31 -0.01 -0.41 -1.78 -0.84 1.36 -0.23 -0.16 0.16 -1.36 -0.26 -0.1 -0.08 -1.49 -1.35 -2.14 -1.96 -0.36 -0.13 -0.16 -0.24 -0.76 -0.38 -0.18 0.04 0.09 -0.78 0.94 -0.59 0.29 -0.17 -0.33 -0.47 -0.54 -0.24 -0.49 -0.49 -0.74 -0.19 0.4 -0.58 -0.73 -1.53 -0.09 -0.11 -0.97 0 -0.69 0.97 -0.32 0.2 -1.35 -0.11 -0.29 -0.38 -0.09 -0.72 -0.91 0.2 -1.2 0.55 1.14 -0.68 -0.58 0.73 0.34 0.35 -0.45 -0.9 -1.19 -0.48 -0.61 -0.05 -0.4 0.36 -0.9 -0.21 0.03 -0.88 -0.17 -0.42 -0.33 -0.06 0.45 -0.51 0.34 -0.22 -0.87 0.73 -0.94 -0.4 -0.91 -1.52 -0.82 0.12 -0.49 0.31 -0.4 -1.19 0.5 0.39 -0.81 -0.92 -0.66 0.87 -0.01 -0.23 -0.45 0.44 -0.01 -0.56 -0.34 -0.63 -0.09 0.66 -0.2 -1.89 -0.04 0.33 -1.77 0.63 -0.6 -0.26 0.35 0.2 -0.24 -1.53 0.74 -0.15 -0.32 -0.47 -1.09 -1.24 -0.34 0.62 0.56 0.39 -0.02 -0.36 0.6 -0.85 -0.33 -0.49 0.02 -0.98 -0.22 -0.37 -0.2 0.15 0.02 -0.02 -0.35 -0.06 0.45 -0.3 -0.85 0.52 0.04 -0.08 -0.61 -0.75 -0.3 -0.29 0.17 -0.78 0.15 0.15 xanthosine-5-phosphate -1.18 -0.68 0.61 0.14 -1.02 5.92 -1.33 -0.99 -0.8 -0.05 -1.34 -1.47 -1.17 -1.87 -0.39 -0.47 -1.63 -0.91 -1.36 -0.18 0.87 0.04 -0.95 -1.34 -0.55 -1.36 -1.45 -0.91 -0.91 0 -0.23 -0.32 -0.1 -1.35 -0.34 -0.85 0.95 0.84 -1.41 -0.88 -0.68 -1.08 -1.12 -0.21 -1.16 -1.44 -0.85 -0.39 -1.03 -0.97 -0.82 -0.53 -0.78 -1.49 -1.28 -0.62 -0.14 0.29 -1.82 1.4 -1.05 0.76 -1.17 -0.47 -0.53 -0.98 0 0.01 -0.55 -1 -1.57 0 -1.32 -1.49 -0.86 -1.32 1.74 -0.16 -0.03 0.1 0.03 -0.67 -0.33 -0.52 -0.46 -1.74 0.26 -0.31 -1.28 -0.84 -0.54 -0.65 -0.12 -0.43 0.07 -0.74 -0.97 0.15 1.5 -0.46 -0.16 -0.27 -1.03 -1.08 -0.66 -0.87 -0.89 0.01 -1.01 -0.85 -0.67 -2.09 -0.37 -0.64 1.97 -0.88 0.47 -0.62 -0.43 -1.02 -0.89 0.14 -0.51 0.37 0.71 -1.12 -0.19 -0.12 -0.47 -1.03 -2.04 0.23 -0.21 -0.96 1 -0.74 -0.75 0.28 -0.82 1.5 -0.99 -1.83 0.04 -0.13 -0.8 -0.58 -0.82 -0.65 -0.41 -0.89 -0.59 -0.27 0.04 0.61 -1.04 -1.75 -1.58 -1.43 -1.06 -1.71 -0.27 -0.2 -0.94 -0.69 0.11 -0.18 -1.29 0.13 -0.63 -0.91 -0.71 -1.22 -0.99 -0.39 -0.56 -1.53 -0.74 -0.41 -1.9 -0.44 -0.27 -1.12 -0.04 -0.06 -0.06 -0.5 -0.02 -0.14 -0.12 -0.12 ADP -1.47 0.07 -0.24 0.1 -0.3 -1.26 0.13 0.19 0.1 -0.07 -0.77 -1.74 -0.02 -0.31 0 0.83 -0.71 0 -0.52 -2.01 -1.41 0.15 0.29 -0.52 -1.22 -0.93 0.21 0.12 -0.15 0.67 -0.08 -0.16 0 -0.39 -0.26 -0.1 -1.2 -1.28 0.27 -0.86 -0.15 -0.45 -0.22 0.09 -0.02 0.25 -0.04 0.13 -0.16 -1.11 1.08 -1.6 0.16 -1.41 0.14 0.21 0.08 0 -0.56 -1.25 -2.57 0.52 0.05 0.24 -0.02 0.68 0.53 0.05 0 -0.03 0 -0.46 0.19 -0.09 -0.11 -0.41 -1.98 -0.28 -0.01 -0.43 0 -0.4 -0.09 -0.1 -0.24 -0.12 -0.41 1.07 0.16 -0.09 -0.17 0.25 -0.06 0.58 0.23 -0.06 -0.17 0.15 0.31 -0.48 0 0.12 0.29 -0.11 -1.75 0.04 -1.56 -0.02 -1.49 -0.15 -0.21 -2.85 -0.2 -0.55 -1.08 0.1 0 -0.32 0.01 -1.41 -1.83 -1.21 0.13 0.19 -1.31 -0.25 0.27 0.27 0.04 -0.15 -1.93 -0.45 -0.16 -1.66 -1.27 -0.25 -0.08 -1.55 -0.18 -1.79 0.06 -0.02 -1.8 0.08 -0.04 -1.36 -0.1 -0.45 0.11 0.19 0.06 -0.26 0 0.19 -1.78 -1.22 -1.1 0.01 0 -0.24 0.36 -0.11 0.39 -0.51 -0.3 -0.66 -0.24 0.09 -0.12 -0.24 -0.19 -0.02 -0.22 -0.23 -0.26 -0.38 -0.22 0.06 -0.1 0.24 -0.03 -0.65 -1.99 -0.15 -0.16 -0.02 0.24 -2.04 0.25 0.25 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name 2-dehydro-D-gluconate 2-Hydroxy-2-methylbutanedioic acid 2-oxo-4-methylthiobutanoate 2_3-Diphosphoglyceric acid 3-phospho-serine 3-phosphoglycerate 4-aminobutyrate 4-phosphopantothenate 4-Pyridoxic acid PRPP 6-phospho-D-gluconate a-ketoglutarate acetyl-CoA Acetyllysine aconitate adenosine ADP-D-glucose ATP carnitine CDP CDP-ethanolamine citrate/isocitrate CMP CTP cyclic-AMP cytidine D-gluconate D-sedoheptulose-1/7-phosphate dAMP dATP dCDP dCMP dCTP deoxyinosine deoxyribose-phosphate dGMP/AMP dihydroorotate DLH dTDP dTMP dTTP dUMP dUTP FAD FMN fructose-1,6-bisphosphate fructose-6-phosphate fumarate G3P/DHAP GDP glucose-1/6-phosphate glutathione disulfide glycerate GMP GTP guanine guanosine hypoxanthine IMP indole inosine lactate LD malate myo-inositol N-acetyl-glucosamine-1/6-phosphate N-acetyl-glutamate N-acetyl-glutamine N-Acetyl-L-alanine N-acetyl-L-ornithine N-carbamoyl-L-aspartate NAD+ NADH NADP+ NADPH nicotinate Octoluse 8/1-phosphate Octoluse Bisphosphate ornithine orotate p-hydroxybenzoate PD PE PEE PEEK phenylpyruvate phosphoenolpyruvate PVNF Pyroglutamic acid Pyrophosphate pyruvate ribose-phosphate S-adenosyl-L-homoCysteine S-methyl-5--thioadenosine sarcosine/alanine SD Sedoheptoluse bisphosphate sn-glycerol-3-phosphate succinate/methylmalonic acid thymidine thymine UDP UDP-D-glucose UDP-D-glucuronate UDP-N-acetyl-glucosamine UMP uridine UTP VD xanthine xanthosine xanthosine-5-phosphate ADP METABOLITES_END #END