#METABOLOMICS WORKBENCH hormel101_20170623_131437 DATATRACK_ID:1093 STUDY_ID:ST000644 ANALYSIS_ID:AN000976 PROJECT_ID:PR000459 VERSION 1 CREATED_ON June 25, 2017, 10:21 pm #PROJECT PR:PROJECT_TITLE Role of the Serine Biosynthesis Pathway in Supporting the Warburg Effect of PR:PROJECT_TITLE Pancreatic Cancer Cells PR:PROJECT_SUMMARY Pancreatic cancer cells metabolize glucose differently than normal adult cells, PR:PROJECT_SUMMARY relying on aerobic glycolysis even in oxygen-rich environments. This phenomenon, PR:PROJECT_SUMMARY known as the Warburg effect, is the basis of PET scans for tumor imaging and PR:PROJECT_SUMMARY diagnosis, but a definitive explanation for how this benefits cancer cells has PR:PROJECT_SUMMARY remained elusive, and altered cell metabolism has not been fully exploited for PR:PROJECT_SUMMARY therapeutic benefit. The Warburg effect is accompanied by expression of the M2 PR:PROJECT_SUMMARY isoform of pyruvate kinase (PK); while many differentiated normal cells express PR:PROJECT_SUMMARY PKM1, proliferating cells, including all cancer cells, express PKM1. We have PR:PROJECT_SUMMARY generated both normal cell lines and pancreatic cancer cell lines that can be PR:PROJECT_SUMMARY genetically controlled to express either PKM1 or PKM2. While normal PR:PROJECT_SUMMARY proliferating cells stop proliferating when forced to express PKM1 rather than PR:PROJECT_SUMMARY PKM2, pancreatic cancer cells proliferate just as rapidly with forced PKM1 PR:PROJECT_SUMMARY expression. Preliminary data shows that pancreatic cancer cells upregulate the PR:PROJECT_SUMMARY serine biosynthesis pathway during forced PKM1 expression. To probe the role of PR:PROJECT_SUMMARY the serine biosynthesis pathway in supporting cancer proliferation in the PR:PROJECT_SUMMARY context of isoform-specific PK expression, we have targeted genes in the serine PR:PROJECT_SUMMARY biosynthesis pathway using the CRISPR/Cas9 system and generated pancreatic PR:PROJECT_SUMMARY cancer knockout cell lines. The proposed research will use isotope-labeled PR:PROJECT_SUMMARY precursors and genetic engineering to identify the metabolic dependencies of PR:PROJECT_SUMMARY pancreatic cancer cells. Genetically engineered pancreatic cancer cell lines PR:PROJECT_SUMMARY cultured with 13C-glucose, 13C-glutamine, or 13C-serine will be extracted and PR:PROJECT_SUMMARY sent to the Mayo Clinic Metabolomics Resource Core for isotopic enrichment PR:PROJECT_SUMMARY analysis of various amino acids, TCA cycle metabolites, fatty acids, and PR:PROJECT_SUMMARY sphingolipids. This work will provide crucial first insight for altered PR:PROJECT_SUMMARY metabolism of pancreatic cancer cells that can lead to novel metabolic targets PR:PROJECT_SUMMARY for effectively treating pancreatic cancer. PR:INSTITUTE Mayo Clinic PR:LAST_NAME Lunt PR:FIRST_NAME Sophia PR:ADDRESS Michigan State University 410B Biochemistry Building 603 Wilson Road East PR:ADDRESS Lansing, MI 48824 PR:EMAIL sophia@msu.edu PR:PHONE 517-432-4886 #STUDY ST:STUDY_TITLE Trace 13C-glucose, 13C-glutamine, and 13C-serine in genetically engineered ST:STUDY_TITLE pancreatic cell lines through ceramides (part III) ST:STUDY_SUMMARY Trace 13C-glucose, 13C-glutamine, and 13C-serine in genetically engineered ST:STUDY_SUMMARY pancreatic cell lines through ceramides ST:INSTITUTE Mayo Clinic ST:LAST_NAME Lunt ST:FIRST_NAME Sophia ST:ADDRESS Michigan State University 410B Biochemistry Building 603 Wilson Road East ST:ADDRESS Lansing, MI 48824 ST:EMAIL sophia@msu.edu ST:PHONE 517-432-4886 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - ms6138-1 experiment:PSAT A13 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-2 experiment:PSAT A13 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-3 experiment:PSAT A13 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-4 experiment:PSAT A13 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-5 experiment:PSAT A13 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-6 experiment:PSAT A13 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-7 experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-8 experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-9 experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-10 experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-11 experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-12 experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-13 experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-14 experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-15 experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-16 experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-17 experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-18 experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSAT SUBJECT_SAMPLE_FACTORS - ms6138-19 experiment:PHGDH B34 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-20 experiment:PHGDH B34 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-21 experiment:PHGDH B34 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-22 experiment:PHGDH B34 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-23 experiment:PHGDH B34 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-24 experiment:PHGDH B34 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-25 experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-26 experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-27 experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-28 experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-29 experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-30 experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-31 experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-32 experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-33 experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-34 experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-35 experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-36 experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH SUBJECT_SAMPLE_FACTORS - ms6138-37 experiment:PSPH B8 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-38 experiment:PSPH B8 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-39 experiment:PSPH B8 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-40 experiment:PSPH B8 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-41 experiment:PSPH B8 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-42 experiment:PSPH B8 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-43 experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-44 experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-45 experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-46 experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-47 experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-48 experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-49 experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-50 experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-51 experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-52 experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-53 experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSPH SUBJECT_SAMPLE_FACTORS - ms6138-54 experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSPH #COLLECTION CO:COLLECTION_SUMMARY Pancreatic ductal adenocarcinoma cell line with PHGDH, PSAT, and PSPH KO. These CO:COLLECTION_SUMMARY cells have been incubated with no label, 13C-glucose or 13C-glutamine label for CO:COLLECTION_SUMMARY 48 hours. #TREATMENT TR:TREATMENT_SUMMARY Pancreatic cancer cells exhibit altered metabolism, which is mediated in part by TR:TREATMENT_SUMMARY expressing the proliferation-supportive M2 isoform of pyruvate kinase (PK). TR:TREATMENT_SUMMARY Unlike normal embryonic cells that stop proliferating when forced to express the TR:TREATMENT_SUMMARY proliferation-incompatible M1 isoform of PK, pancreatic cancer cells can TR:TREATMENT_SUMMARY proliferate just as rapidly with either the M1 or M2 isoform. During forced PKM1 TR:TREATMENT_SUMMARY expression, pancreatic cancer cells upregulate their serine biosynthesis TR:TREATMENT_SUMMARY pathway. The three enzymes in the serine biosynthesis pathway include TR:TREATMENT_SUMMARY phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT), TR:TREATMENT_SUMMARY and phosphoserine phosphatase (PSPH). Each of the genes encoding the three TR:TREATMENT_SUMMARY enzymes in the serine biosynthesis pathway have successfully been knocked out TR:TREATMENT_SUMMARY from pancreatic cancer cells using the CRISPR/Cas9 system in our laboratory, TR:TREATMENT_SUMMARY with multiple confirmed clones for each knockout ready for metabolic TR:TREATMENT_SUMMARY characterization. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY In this proposal, we will interrogate the metabolic pathways that support SP:SAMPLEPREP_SUMMARY pancreatic cancer proliferation by performing isotope enrichment analysis on the SP:SAMPLEPREP_SUMMARY CRISPR/Cas9 knockout pancreatic cancer cell lines. Each cell line expressing SP:SAMPLEPREP_SUMMARY PKM1 or PKM2 will be seeded on 6-well plates so that they are ~70% confluent at SP:SAMPLEPREP_SUMMARY the time of labeled media addition. Unlabeled media will be aspirated, and cell SP:SAMPLEPREP_SUMMARY will be washed with PBS. Media labeled with 13C-glucose, 13C-glutamine, or SP:SAMPLEPREP_SUMMARY 13C-serine labeled media will be added, and cells will be incubated for 1 hour SP:SAMPLEPREP_SUMMARY or 24 hours. Polar metabolites and fatty acids will be extracted at the end of SP:SAMPLEPREP_SUMMARY the incubation period using methanol, water, and chloroform. The methanol/water SP:SAMPLEPREP_SUMMARY fraction containing polar metabolites will be separated from the chloroform SP:SAMPLEPREP_SUMMARY fraction containing fatty acids, and each fraction will be dried down under SP:SAMPLEPREP_SUMMARY nitrogen. Dried down samples will be sent to the Mayo Clinic Metabolomics SP:SAMPLEPREP_SUMMARY Resource Core for analysis of TCA cycle intermediates, amino metabolites, free SP:SAMPLEPREP_SUMMARY fatty acids, and sphingolipids. TCA cycle intermediates and amino metabolites SP:SAMPLEPREP_SUMMARY (polar metabolites) should become labeled faster than fatty acids and SP:SAMPLEPREP_SUMMARY sphingolipids; therefore, polar metabolites are proposed to be analyzed at 1 SP:SAMPLEPREP_SUMMARY hour and 24 hours after 13C-label addition. Fatty acids are proposed to be SP:SAMPLEPREP_SUMMARY analyzed for the 24 hr time point only, due to slow labeling. Statistical SP:SAMPLEPREP_SUMMARY analysis will be performed by the Mayo Clinic Metabolomics Resource Core. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Waters Acquity CH:COLUMN_NAME Waters Acquity BEH C8 (150 x 2mm, 1.7um) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME Agilent 6550 QTOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE POSITIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS % enrichment: MPE MS_METABOLITE_DATA_START Samples ms6138-1 ms6138-2 ms6138-3 ms6138-4 ms6138-5 ms6138-6 ms6138-7 ms6138-8 ms6138-9 ms6138-10 ms6138-11 ms6138-12 ms6138-13 ms6138-14 ms6138-15 ms6138-16 ms6138-17 ms6138-18 ms6138-19 ms6138-20 ms6138-21 ms6138-22 ms6138-23 ms6138-24 ms6138-25 ms6138-26 ms6138-27 ms6138-28 ms6138-29 ms6138-30 ms6138-31 ms6138-32 ms6138-33 ms6138-34 ms6138-35 ms6138-36 ms6138-37 ms6138-38 ms6138-39 ms6138-40 ms6138-41 ms6138-42 ms6138-43 ms6138-44 ms6138-45 ms6138-46 ms6138-47 ms6138-48 ms6138-49 ms6138-50 ms6138-51 ms6138-52 ms6138-53 ms6138-54 Factors experiment:PSAT A13 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSAT experiment:PSAT A13 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSAT experiment:PSAT A13 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSAT experiment:PHGDH B34 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH experiment:PHGDH B34 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH experiment:PHGDH B34 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PHGDH experiment:PSPH B8 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:No label | time:0 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:No label | time:0 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glucose | time:48 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glucose | time:48 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSPH experiment:PSPH B8 + Dox (PKM1) | tracer:13C-glutamine | time:48 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSPH experiment:PSPH B8 - Dox (PKM2) | tracer:13C-glutamine | time:48 hr | group ID:PSPH Sphingosine m0 99.57501781 99.39061223 99.62355868 98.94731349 99.51957926 98.51492533 62.73767649 61.1178562 62.89053445 65.59212249 64.72859793 65.18835846 73.72463618 77.59405128 78.05281582 78.69090241 80.13135967 77.31976044 99.73153782 99.77884579 99.49504314 99.95276992 98.55816972 99.09197075 68.61527136 70.10302425 68.34208934 68.7159433 68.90803349 62.99497562 80.2123959 79.83990532 77.79117059 79.80748045 78.07777198 77.55982647 99.03953032 99.60640521 97.85377969 99.89525743 98.93045483 97.75355607 72.37724371 73.60536448 73.4227977 71.81069656 70.48283123 71.50792679 82.98583841 82.30869655 81.65173533 82.28685289 81.66577165 79.9110032 Sphingosine m+1 0 0.421031161 0.316163037 0.604743914 0.185762814 0.664216469 0 0 0.097094351 0.628972765 0.324766457 0.805971658 1.18805445 0.71570061 0.580287086 0.330580137 0.587407664 1.269185093 0 0 0 0 0.798738841 0.182250223 0.716852462 0.362886927 0.402885456 0.330835314 0 0 0.441287083 0.822093803 0.654373867 0 1.759072893 1.273207537 0 0 0.108036427 0 0.628694719 1.040061505 1.019038732 0 0.767137978 0.397829884 0.616633841 0.033339527 1.20765069 0.656788112 1.462768374 1.494783396 0.606695286 1.836227975 Sphingosine M+2 0.183704834 0 0 0.447942598 0.294657922 0 0.281657341 0.598957811 0.532391038 0.692902941 0.666526969 0.585262001 10.07928102 9.894741991 9.370992407 9.596064754 8.685910789 8.854364579 0.268462176 0.221154208 0.504956857 0.047230082 0.556416369 0.725779024 0.413492872 0.56206844 0 0.43477681 0.483475108 0.907046714 8.236767221 8.445681307 9.605652319 9.341517179 9.607611209 8.530781775 0.288902462 0.393594789 0.186085907 0 0 0.035431407 0.432690463 0.623626814 0.641914909 0.23677068 0.382434169 0.610057089 5.976681671 7.918270853 7.371531193 6.884351016 7.939359959 8.253755591 Sphingosine m+3 0.165538943 0.188356606 0.060278284 0 0 0 0 0 0 0 0 0 1.716166095 1.166266221 1.492466059 0.914487676 1.072759247 0.997738922 0 0 0 0 0 0 0 0 0 0.222030636 0.324842512 0 1.206205554 1.174377972 1.085057885 0.807044217 0.912979766 0.929341187 0 0 0.419754351 0.104742568 0 0.099426609 0 0 0.103225548 0 0 0.099504745 1.376150719 0.534069438 0.953593909 1.367683214 1.40680527 1.831144185 Sphingosine m+4 0 0 0 0 0 0 0 0 0 0 0 0.965209193 7.509736999 7.597534738 6.432818811 5.868859714 6.722812669 7.131703856 0 0 0 0 0 0 0 0 0 0 0 1.057387086 6.728059667 5.564928228 6.608679521 5.008367498 6.084472995 6.614022919 0.342809993 0 0 0 0 0 1.148498602 0.468344515 0 0 0 0.336958899 4.412951983 5.658554885 4.898499475 4.474092245 4.393237992 4.578894341 Sphingosine m+5 0 0 0 0 0 0 0 1.488466751 0 0 0 0 2.34147743 0.265802402 1.295699075 2.573494953 0.093484917 1.364251727 0 0 0 0 0 0 0 0 0 0 0 0 0.006606771 1.091949713 1.123323667 2.608868456 1.444580656 2.119438168 0 0 0 0 0 0 0 0 0 0 0 0 1.541065478 0.847470731 0.937438725 1.268697033 1.212250907 0.506188594 Sphingosine m+6 0 0 0 0 0 0 1.119097897 0.735395631 0.964078272 0 1.221702125 0.861063862 3.000634321 2.765902757 2.774920742 2.025610353 2.706265046 2.674335478 0 0 0 0 0 0 0 0 0 0 0 0 2.937115255 2.58347843 2.564165978 2.346545292 2.113510504 2.534481895 0 0 0 0 0 0 0.996339078 1.031147943 0 0.748274536 0.845672182 0.939773561 1.607005372 2.076149431 1.991858934 1.798455394 1.953823687 2.197875209 Sphingosine m+7 0 0 0 0 0 0 0.172310371 0.230143199 0 0 0.237713427 0 0.440013501 0 0 0 0 0.388659905 0 0 0 0 0 0 0 0 0 0 0 0 0.231562552 0.379153036 0.348084831 0 0 0.438900046 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.884910903 Sphingosine m+8 0 0 0 0 0 0 2.551444526 2.534898911 2.676364132 2.395655188 2.566192934 1.926498738 0 0 0 0 0 0 0 0 0 0 0 0 1.371132217 0 0 1.371111957 0 1.627494334 0 0 0 0 0 0 0 0 0 0 0 0 1.842169998 1.882009792 1.918723228 1.891827117 1.939083896 1.643192621 0.529542559 0 0.492403296 0.42508481 0.822055248 0 Sphingosine m+9 0 0 0 0 0 0 0.186253986 0.277307846 0.169606407 0.225274634 0.088940376 0.262978012 0 0 0 0 0 0 0 0 0 0 0 0 0.66154371 0.864471506 0.846150725 0.387931888 0.75269101 0.401348185 0 0 0 0 0 0 0 0 0 0 0 0 0.349960637 0.010905898 0.441808153 0.156517303 0.387095487 0.399987947 0 0 0 0 0 0 Sphingosine m+10 0 0 0 0 0 0 6.306412792 6.21346266 6.424207768 5.83258646 6.529382384 5.763631631 0 0 0 0 0 0 0 0 0 0 0 0 4.114380344 4.388722413 4.761799592 4.288394518 4.249955584 5.216522504 0 0 0 0 0 0 0 0 0 0 0 0 4.54343006 4.76372327 5.023742899 4.246447188 5.053346096 4.70466396 0 0 0 0 0 0 Sphingosine m+11 0 0 0 0 0 0 0.573000388 0.74115939 0.894651183 0.785650428 0.55896494 0.533989096 0 0 0 0 0 0 0 0 0 0 0 0 1.314238458 1.173069136 1.107366424 1.005501465 1.227040066 1.345740065 0 0 0 0 0 0 0 0 0 0 0 0 0.490640153 0.380424574 0.847768582 0.237427815 0.380186298 0.199294094 0 0 0 0 0 0 Sphingosine m+12 0 0 0 0 0 0.820858198 9.229433949 9.280528365 8.979755364 8.800648634 8.951069448 8.294220694 0 0 0 0 0 0 0 0 0 0 0.086675066 0 7.037450219 7.054728863 7.40546057 6.670748116 6.95502309 7.726693182 0 0 0 0 0 0 0 0 1.226453215 0 0 0.743062014 6.514399382 6.446853601 5.215455989 7.213697336 7.229928004 7.361997907 0 0 0 0 0 0 Sphingosine m+13 0 0 0 0 0 0 0.867742585 0.888531779 0 0.456291821 0.643266386 0.903855587 0 0 0 0 0 0 0 0 0 0 0 0 1.631663689 1.4255626 1.819826119 1.61664901 1.509917541 1.742368096 0 0 0 0 0 0 0 0 0 0 0 0 0.565594094 0.510724703 0.877676595 0.683399567 0.975299788 0.777782396 0 0 0 0 0 0 Sphingosine m+14 0.075738414 0 0 0 0 0 9.942185685 9.610987689 10.20134686 9.067857896 7.860321001 8.941049109 0 0 0 0 0 0 0 0 0 0 0 0 8.094194272 8.02992644 8.981532834 8.176549719 8.834803078 9.545803598 0 0 0 0 0 0 0.328757227 0 0 0 0.19387309 0.328462395 5.784423245 6.340884508 6.902852975 7.104685497 6.596875931 6.802281223 0 0 0 0 0 0 Sphingosine m+15 0 0 0 0 0 0 0.512520291 0.152859171 0.137615741 0.647081764 0.607554562 0.085977923 0 0 0 0 0 0 0 0 0 0 0 0 0.846922435 0.787878387 0.869239981 1.0145403 1.261956251 1.174773928 0 0 0.219491346 0 0 0 0 0 0 0 0 0 0.171939756 0.477018295 0 0.635296048 0.382760933 0.31607989 0 0 0 0 0 0 Sphingosine m+16 0 0 0 0 0 0 5.392423241 5.916627078 5.961350281 4.654977039 4.871742303 4.881934036 0 0 0 0 0 0 0 0 0 0 0 0 5.039921317 5.036235165 5.356924515 5.662328062 5.266778861 6.004162908 0 0 0 0 0 0 0 0 0.205890411 0 0.24697736 0 3.697013327 3.458971606 3.60550256 4.483839762 4.58922319 4.131220994 0.363113113 0 0 0 0 0 Sphingosine m+17 0 0 0 0 0 0 0.127840456 0.212817516 0.071004158 0.219977938 0.14325876 0 0 0 0 0 0 0 0 0 0 0 0 0 0.142936643 0.211425875 0.106724441 0.102658905 0.225483412 0.255683775 0 0 0 0.080176906 0 0 0 0 0 0 0 0 0.06661876 0 0.231392886 0.153290708 0.13862896 0.135938361 0 0 0.240170763 0 0 0 Sphingosine m+18 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.098432196 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sphinganine m0 100 100 99.90112136 99.59690644 99.79318782 100 45.30304226 46.97239439 45.8111666 54.09059778 49.66130251 53.39432537 59.86562778 59.32669192 60.77841575 82.81165815 65.83762854 81.52936307 100 100 99.43715005 99.85860185 100 100 51.50556821 54.87181108 53.30470402 57.03070283 50.44114638 50.80242047 79.45257997 64.13513159 78.67389686 80.62450225 78.80049427 83.9062474 99.77652991 99.35385361 100 99.46345587 99.24535894 99.60290898 53.81482814 46.44101116 53.28923816 50.724426 46.86688271 44.98551741 66.54760271 67.56739193 67.41119712 67.8920891 64.5056787 64.31853804 Sphinganine m+1 0 0 0.098878639 0.403093558 0.206812183 0 0.047638894 0 0 0 0.084236694 1.135390118 1.773539002 1.960813638 2.095353471 2.694731669 0.970343392 3.762112252 0 0 0.56284995 0.141398154 0 0 0.957077178 0.856582192 0.106847201 0 0.596231076 1.187935452 1.86091815 0.993985676 3.089423006 2.27330931 3.484084976 1.628452719 0.22347009 0.64614639 0 0 0.754641065 0.39709102 0.364489351 0.708517664 0.450331427 0.067137028 0.723615226 0.588110795 2.174591089 2.941392444 1.891682777 2.786046049 3.81208375 3.747530964 Sphinganine M+2 0 0 0 0 0 0 0 0 0 0 0 0 23.18337081 22.91032327 22.06904957 0 19.3353834 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20.31864942 0 0 0 0 0 0 0 0.536544134 0 0 0 0 0 0 0 0 17.60088626 17.2263492 17.67675444 16.88176875 16.42408042 15.92782212 Sphinganine m+3 0 0 0 0 0 0 0 0 0 0 0 0 1.813347793 2.620380396 2.259082141 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.559268956 2.535753669 3.035083997 2.219965795 Sphinganine m+4 0 0 0 0 0 0 0 0 0 0 0 0 8.986288467 8.509377978 8.427889682 10.41260567 8.4340774 10.29816715 0 0 0 0 0 0 0 0 0 0 0 0 11.96993664 9.232953768 12.91409879 12.19201937 11.84800018 12.56529456 0 0 0 0 0 0 0 0 0 0 0 0 8.560437361 7.442752934 7.303909398 6.682074537 7.646622944 8.148259248 Sphinganine m+5 0 0 0 0 0 0 0 0 0 0 0 0 0.688071352 0.972223389 0.758973431 1.122078414 0.640401714 1.234463227 0 0 0 0 0 0 0 0 0 0 0 0 1.694713206 0.940003402 0.299467162 1.160637352 0.867679875 1.900005318 0 0 0 0 0 0 0 0 0 0 0 0 1.442608403 1.453192382 1.073727485 1.021053187 0.936999046 0.482231122 Sphinganine m+6 0 0 0 0 0 0 0 2.087803195 1.443485679 0 0 0 3.689754796 3.700189412 3.08568069 2.958926098 3.511411512 3.175894296 0 0 0 0 0 0 0 0 0 0 0 0 5.02185203 3.865514109 5.023114174 3.238840134 2.95265058 0 0 0 0 0 0 0 0 0 0 0 0 0 3.673874175 3.368921111 3.083459821 2.201214705 3.639451144 4.340426717 Sphinganine m+7 0 0 0 0 0 0 0 0 0.749039702 0 0 0 0 0 0.525555271 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.513762036 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sphinganine m+8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sphinganine m+9 0 0 0 0 0 0 1.195079159 2.212050769 0 0 2.874985096 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.206966212 0 0 0 0 0 0 0 0 0 Sphinganine m+10 0 0 0 0 0 0 7.756006645 0 6.715796559 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.917691432 0 0 3.624985648 4.841545385 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.544657877 0 0 8.385312148 8.859844126 0 0 0 0 0 0 Sphinganine m+11 0 0 0 0 0 0 0 0.003443955 0.006690577 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.812283459 0.559739995 0 1.071212672 0 0 0 0 0 0 0 0 0 0 0 0 1.968745495 0.835799005 0.959389581 0.561412516 0.434799803 0 0 0 0 0 0 0 Sphinganine m+12 0 0 0 0 0 0 16.02603585 16.88428647 14.8900243 16.88490211 17.01669283 15.14868129 0 0 0 0 1.270754039 0 0 0 0 0 0 0 13.06250778 13.78059154 13.58800329 11.46546038 13.60430467 13.93463013 0 0 0 0 2.047090123 0 0 0 0 0 0 0 15.39609793 14.57004595 14.67439394 15.39602755 14.19957474 15.41792412 0 0 0 0 0 0 Sphinganine m+13 0 0 0 0 0 0 0.642855429 0.795013033 0.575059881 1.65236998 0.636415611 1.636422068 0 0 0 0 0 0 0 0 0 0 0 0 2.884935579 3.292151831 2.581871023 2.756432299 2.676804443 3.81123807 0 0 0 0.510691587 0 0 0 0 0 0 0 0 0.140232579 0.968565516 0.618513642 0.841565198 0.67462443 0.621491294 0 0 0 0 0 0 Sphinganine m+14 0 0 0 0 0 0 17.67953216 18.26409682 18.20382823 16.01025493 18.74948035 17.24439508 0 0 0 0 0 0 0 0 0 0 0 0 13.60043664 15.81278816 16.16502008 14.08419212 15.59787602 16.25964062 0 0 0 0 0 0 0 0 0 0 0 0 17.76199078 17.08187341 17.96495117 18.75430592 17.20477839 17.82826382 0 0 0 0 0 0 Sphinganine m+15 0 0 0 0 0 0 0.495639259 0.757377146 0.55295063 0.781401557 0.705415958 0.791987417 0 0 0 0 0 0 0 0 0 0 0 0 1.987330267 1.842186841 2.163167702 1.775433729 1.689356905 2.107454731 0 0 0 0 0 0 0 0 0 0 0 0 1.160785996 1.515635853 0.071467561 0.680684005 0.971489156 0.314411605 0 0 0 0 0 0.815225992 Sphinganine m+16 0 0 0 0 0 0 10.43407163 11.50738976 11.05195783 10.40714961 9.628821313 10.64879865 0 0 0 0 0 0 0 0 0 0 0 0 8.473376937 8.989834839 9.610673389 8.703053001 10.11473355 10.38958601 0 0 0 0 0 0 0 0 0 0 0 0 9.392829719 8.759459417 9.764748302 12.21837863 10.05241512 11.0424217 0 0 0 0 0 0 Sphinganine m+17 0 0 0 0 0 0 0.420098706 0.516144467 0 0.173324029 0.642649636 0 0 0 0 0 0 0 0 0 0 0 0 0 0.611075974 0.554053522 0.454077245 0 0.438001571 0.435881855 0 0 0 0 0 0 0 0 0 0 0 0 0 0.574434147 0 0.262216853 0.486508276 0.342015141 0 0 0 0 0 0 Sphinganine m+18 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.21335259 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.493846296 0 0 0 0 0 0 0 0 C8-Ceramide m0 ND ND ND ND ND ND 5.488445235 5.118585133 5.70983033 6.517692336 7.1832579 8.357053441 60.84589658 54.09127445 100 100 100 100 ND ND ND ND ND ND 8.790131072 9.226009953 9.107983701 11.69800797 9.000088013 9.045149066 100 100 100 100 67.40968541 100 ND ND ND ND ND ND 11.97620014 11.60390963 13.05661382 10.01637318 10.34348063 10.76968589 ND ND ND ND ND ND C8-Ceramide m+1 ND ND ND ND ND ND 8.53610652 8.182517348 8.524271694 10.0835786 9.607754553 10.2276582 39.15410342 30.47286875 0 0 0 0 ND ND ND ND ND ND 13.11181415 13.61233339 12.72311199 12.72419108 14.19557987 13.83910181 0 0 0 0 32.59031459 0 ND ND ND ND ND ND 16.15628605 17.38120754 18.68450256 13.29949162 13.89111118 13.51192227 ND ND ND ND ND ND C8-Ceramide M+2 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+3 ND ND ND ND ND ND 0.353563589 0.45909364 0 0 0 0 0 15.4358568 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0.595301502 0 0 ND ND ND ND ND ND C8-Ceramide m+4 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+5 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+6 ND ND ND ND ND ND 0.786231931 0.591742415 0.763264381 0 0.977666411 0.975371016 0 0 0 0 0 0 ND ND ND ND ND ND 0.824472569 0 1.009028908 0 1.048556739 1.058495826 0 0 0 0 0 0 ND ND ND ND ND ND 1.258488478 1.304207874 1.375569818 0.795036062 1.265360162 1.211787889 ND ND ND ND ND ND C8-Ceramide m+7 ND ND ND ND ND ND 3.54306249 3.258193126 3.181804975 3.11254345 3.426456194 2.79028572 0 0 0 0 0 0 ND ND ND ND ND ND 3.632932999 3.467079068 2.593208152 1.981773522 2.470986007 2.991647811 0 0 0 0 0 0 ND ND ND ND ND ND 4.444473035 3.446138749 4.304308017 2.954203469 3.472637122 2.574625166 ND ND ND ND ND ND C8-Ceramide m+8 ND ND ND ND ND ND 0.837791501 0.842915192 0.918400197 0.759848862 0.910794038 0.717991448 0 0 0 0 0 0 ND ND ND ND ND ND 1.496891425 1.368058897 1.323581697 1.584640382 1.056967958 1.203820434 0 0 0 0 0 0 ND ND ND ND ND ND 0.913184182 1.086843395 0.92938878 1.434626164 0.944260499 0.778918539 ND ND ND ND ND ND C8-Ceramide m+9 ND ND ND ND ND ND 8.022479302 8.382886394 7.583617985 8.329615285 9.111118081 8.184894921 0 0 0 0 0 0 ND ND ND ND ND ND 7.04880298 6.737770015 6.537821025 5.815507626 5.578720658 6.726893324 0 0 0 0 0 0 ND ND ND ND ND ND 8.056353084 8.910345086 8.824994381 7.077878839 5.774335358 7.85159005 ND ND ND ND ND ND C8-Ceramide m+10 ND ND ND ND ND ND 1.627228899 1.33093809 1.670777575 1.395055052 1.317435135 2.149984081 0 0 0 0 0 0 ND ND ND ND ND ND 3.16649414 2.499175747 2.679712208 2.543917412 2.589587335 2.135331209 0 0 0 0 0 0 ND ND ND ND ND ND 1.749867742 1.347581549 1.855599917 2.655291926 3.086122313 2.750255923 ND ND ND ND ND ND C8-Ceramide m+11 ND ND ND ND ND ND 15.88203579 15.94176664 15.32518772 15.01133189 16.55426689 13.40651557 0 0 0 0 0 0 ND ND ND ND ND ND 12.45070353 12.45171794 11.82304914 10.1701822 11.21633294 12.27745001 0 0 0 0 0 0 ND ND ND ND ND ND 13.21197988 12.85048017 14.48040676 12.80647972 13.31100863 12.82833853 ND ND ND ND ND ND C8-Ceramide m+12 ND ND ND ND ND ND 1.3286773 0.825788657 1.099042393 1.588115903 0.430081688 1.67230469 0 0 0 0 0 0 ND ND ND ND ND ND 3.233673173 3.208402191 3.456385374 3.64731212 3.502941518 3.135096751 0 0 0 0 0 0 ND ND ND ND ND ND 1.10053412 1.871325762 0.587801162 1.577509843 1.894044898 1.768956387 ND ND ND ND ND ND C8-Ceramide m+13 ND ND ND ND ND ND 23.19014418 23.92398708 23.48475595 21.33877803 22.48224167 20.61774371 0 0 0 0 0 0 ND ND ND ND ND ND 18.49494532 19.01227745 18.35034262 18.13062569 17.88456692 18.00147769 0 0 0 0 0 0 ND ND ND ND ND ND 18.39037023 17.64498269 19.66692572 18.35218018 18.50197082 18.91539287 ND ND ND ND ND ND C8-Ceramide m+14 ND ND ND ND ND ND 0.622061035 0.269499502 0 0.884897946 0.511677865 1.234489852 0 0 0 0 0 0 ND ND ND ND ND ND 3.542956778 2.978126741 3.124086957 4.240049798 3.647275207 3.066641932 0 0 0 0 0 0 ND ND ND ND ND ND 0.27414911 1.044942283 0.770178135 1.787346714 1.895320997 1.379532302 ND ND ND ND ND ND C8-Ceramide m+15 ND ND ND ND ND ND 20.46050169 21.37730102 22.40048755 20.92177377 18.67105861 19.51400578 0 0 0 0 0 0 ND ND ND ND ND ND 16.60502827 17.05088433 18.17206446 17.99971866 18.4818852 18.02903101 0 0 0 0 0 0 ND ND ND ND ND ND 15.69965357 15.18692324 15.46371093 17.34630318 17.46221139 17.17298818 ND ND ND ND ND ND C8-Ceramide m+16 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+17 ND ND ND ND ND ND 9.321670542 9.494785765 9.338559257 10.05676888 8.816190968 10.15170157 0 0 0 0 0 0 ND ND ND ND ND ND 7.601153588 8.388164284 9.099623775 9.464073534 9.326511633 8.489863124 0 0 0 0 0 0 ND ND ND ND ND ND 6.768460373 6.321112031 0 9.301977607 8.158135995 8.486006023 ND ND ND ND ND ND C8-Ceramide m+18 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+19 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+20 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+21 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+22 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+23 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+24 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+25 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C8-Ceramide m+26 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 0 0 0 0 0 0 ND ND ND ND ND ND 0 0 0 0 0 0 ND ND ND ND ND ND C14 Ceramide m0 90.01613455 89.96344066 92.28225709 94.11383326 93.83524878 91.18687219 53.23899167 73.97488208 43.56681161 72.79065883 53.70689375 49.76221546 53.34015285 57.13364256 54.61366917 54.03580179 62.54552295 58.89608854 87.3455792 91.84833919 96.56824331 89.581632 97.8753386 98.10434363 66.29370118 64.54661537 45.71810168 58.59688297 81.69229118 96.77965032 57.128248 55.92166574 0 0 0 60.25235429 96.62385693 88.65592863 90.50877142 88.99007346 85.92992481 84.77090037 92.09052879 40.98512334 95.9380924 54.47272768 53.58063367 100 65.13488601 63.0257565 56.84912005 58.86238893 51.56253665 44.90086086 C14 Ceramide m+1 3.408003269 1.826038975 2.174810006 0.476422295 1.012945822 3.74892989 0 1.056415856 2.162391272 11.42669916 3.417132736 0 6.235080138 0 8.376062662 7.883509069 0 0.115836629 7.413278367 2.76057702 1.078617844 7.61846707 2.124661403 1.895656371 3.629014282 6.793255091 8.234251661 2.543932768 6.1382262 3.220349678 1.326032762 2.921909579 0 0 0 1.428588335 3.37614307 7.356708998 8.908747497 8.417413691 4.481687759 11.03205831 7.909471213 2.096676253 4.061907599 3.538495104 5.098105162 0 4.616852127 6.362149005 10.20411545 9.262629093 12.48093952 9.659141316 C14 Ceramide M+2 2.556575466 4.82546655 5.542932901 5.409744443 3.248899508 1.0726324 0 0 0 15.78264201 0 13.77433084 14.03086031 24.97947179 21.63929005 23.0646366 16.65690007 20.49257917 5.241142432 3.328595971 2.353138843 2.799900934 0 0 0 12.33211444 10.53018302 0 12.16948262 0 21.04478053 13.14666511 0 0 4.501575433 17.74214504 0 3.987362373 0.582481082 0 1.185722963 0 0 0 0 0 0 0 16.23200379 15.17605084 15.95801679 15.1346667 14.70693095 26.58315666 C14 Ceramide m+3 0 0 0 0 0 0 0 0 0 0 0 0 6.986747656 2.09651276 2.448041335 0.326985653 5.246195179 6.56586266 0 0 0 0 0 0 0 0 0 0 0 0 2.943489037 7.696517395 0 0 0 7.954005928 0 0 0 2.592512847 0 0 0 0 0 4.005070586 0 0 3.51238326 5.377595248 2.269174811 4.645415269 0 3.405590212 C14 Ceramide m+4 0 0 0 0 1.902905886 0 7.4905824 0 0 0 0 0 10.65708955 11.99800978 10.78970962 11.63063672 11.58117643 8.693580167 0 0 0 0 0 0 0 0 0 0 0 0 11.54605391 8.508130306 0 0 0 10.80940105 0 0 0 0 0 0 0 0 0 0 0 0 7.482002832 8.03895521 6.872674993 10.298363 9.186688242 7.392782776 C14 Ceramide m+5 0 0 0 0 0 0 10.68530991 0 0 0 0 0 2.695126468 3.792363113 2.133227162 3.058430165 3.970205374 5.236052832 0 0 0 0 0 0 0 0 0 0 0 0 3.2515147 3.533073071 0 0 0 1.81350536 0 0 0 0 0 0 0 4.279248958 0 0 4.927860062 0 3.021871981 2.019493192 3.439870075 1.796537005 2.936759846 3.630396545 C14 Ceramide m+6 0 0 0 0 0 0 8.962047285 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.24595926 0 0 0 0 0 0 0 0 C14 Ceramide m+7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.429308441 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+10 0 0 0 0 0 0 0 0 54.27079712 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31.89756652 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.392919701 0 22.72116908 15.88396786 0 0 0 0 0 0 0 C14 Ceramide m+12 0 0 0 0 0 0 0 0 0 0 42.87597351 36.46345371 0 0 0 0 0 0 0 0 0 0 0 0 30.07728453 0 35.51746364 22.34694181 0 0 0 0 38.13822092 46.80214706 45.69486324 0 0 0 0 0 0 0 0 12.25042645 0 3.016578294 20.50943324 0 0 0 0 0 0 0 C14 Ceramide m+13 0 0 0 0 0 0 19.62306873 24.96870206 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.459567661 0 0 0 0 0 0 0 0 0 0 5.66873034 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.12102538 0 0 0 0 8.244550096 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8.391217065 0 0 0 0 16.25214665 20.24128544 22.33883112 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.376418751 4.980055847 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+18 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.683476401 11.49453142 12.89129906 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.122533548 0 2.503741519 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.093205566 6.306415526 5.572215243 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+21 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.537448011 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+25 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+26 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.40702783 0 0 0 C14 Ceramide m+27 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7.072019947 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16.3280151 0 0 0 0 2.759881068 8.272038791 5.092432402 0 6.497474385 0 0 0 0 0 8.402664466 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+29 4.019286719 3.38505382 0 0 0 3.991565517 0 0 0 0 0 0 6.054943017 0 0 0 0 0 0 2.062487823 0 0 0 0 0 0 0 0 0 0 0 0 0 3.103544757 0 0 0 0 0 0 0 4.19704132 0 0 0 0 0 0 0 0 0 0 9.126144788 4.428071634 C14 Ceramide m+30 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+31 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C14 Ceramide m+32 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C16 Ceramide m0 99.33354206 3.121686976 99.78267813 99.81707817 99.59925755 100 38.86219483 45.5669585 41.61082163 41.95971114 37.68168748 41.60024989 60.73515036 61.65160278 62.75058185 66.0208541 65.66933139 65.1873654 99.93417096 99.57108875 100 1.664997085 99.75013017 99.30282016 45.27469173 1.253350242 45.84190691 43.64186023 44.68323561 41.00552485 4.139779083 3.038666876 4.010891454 62.65578237 61.52575378 61.29937882 99.37647344 98.75509173 98.21350787 98.94036102 99.95474226 98.73328949 42.99484361 41.9667167 42.59018761 43.81285638 41.81548832 42.79998864 66.78021255 66.51500952 67.99365258 68.28392408 65.86845448 64.25308487 C16 Ceramide m+1 0 0 0 0 0 0 0 0.06186082 0 0 0 0 1.052789927 1.5478364 1.204575762 1.618286571 2.12529372 2.007254061 0 0 0 0 0 0 0 0.451672786 0 0.107766618 0 0 1.845898467 0 0 0.236585446 2.005613042 0.795509472 0 0 0 0 0 0 0 0 0 0 0 0 0.729434338 1.231915178 0.483840074 1.296123953 0.652749085 2.0173768 C16 Ceramide M+2 0 59.58529839 0 0 0 0 0.819430658 0.88616085 0.374082308 0.615179203 1.482272289 0.515265689 12.65980815 13.0009488 12.70392505 11.25234948 10.54883356 11.54400837 0 0 0 83.5682525 0 0 0 4.088818985 0.379837914 0.501219311 0.389708803 0.89659906 13.52326957 18.50436358 15.83820442 12.5311064 11.54540207 12.12645087 0 0 0 0 0 0 0.262896943 0.593604198 0.002610579 0.402845522 0.42675945 0.340780382 11.29728982 10.53672749 10.46588334 9.997924626 10.95475456 10.96774161 C16 Ceramide m+3 0.096049032 0.512083825 0.011797043 0 0 0 0 0.440710896 0 0.475296837 0.408657208 1.049619637 2.89064344 2.298979746 2.468097918 1.567215743 1.185178754 1.314752241 0.065829043 0 0 2.398693412 0 0 0.459588542 0.604830022 0.110689143 0.138616177 0.453934491 0 3.47251149 3.994147014 3.045441421 1.840431022 1.799486402 2.651238513 0 0 0 0 0.045257741 0 0.214671008 0.189751839 0.251615335 0.2028839 0.245369744 0.300368704 1.946009259 1.812847669 2.24542157 1.942754319 1.877590694 1.819383005 C16 Ceramide m+4 0 0 0.038054534 0 0 0 0 0 0 0 0 0 9.459096276 9.528798329 8.799811931 8.700615905 9.112116948 8.878174914 0 0 0 0 0 0 0 0 0 0 0 0 18.62501132 18.89566204 17.13026721 9.142921726 9.54918571 9.462143994 0 0 0 0 0 0 0 0.484083386 0 0 0.495638096 0 7.750344275 8.520515056 7.904733735 7.339054685 7.660017333 8.275685533 C16 Ceramide m+5 0 0 0 0 0 0 0 0 0 0 0 0 1.123389928 1.842441136 1.020327453 0.650183528 1.305986918 1.315020508 0 0 0 0 0 0 0 0 0 0 0 0 4.814187287 2.424774514 5.229762097 1.728123713 1.469934211 1.878966638 0 0 0 0 0 0 0 0 0 0 0 0 1.627221242 1.283741672 1.148995943 1.430335185 1.751737705 1.450868255 C16 Ceramide m+6 0 0 0 0 0 0 0 0 0 0 0 0 5.218745933 4.877233862 5.066211066 5.320603983 5.403220229 4.520046781 0 0 0 0 0 0 0 0 0 0 0 0 15.14237749 18.21826009 15.48624703 5.126626174 5.397807499 5.386475209 0 0 0 0 0 0 0 0 0 0 0 0 4.502214943 4.543390866 4.654017115 3.836424828 3.959066351 4.895288589 C16 Ceramide m+7 0 0 0 0 0 0 0 0 0 0 0 0 0.999163698 0.584712384 0.547991029 0.636309621 0.187456908 1.115748449 0 0 0 0 0 0 0 0 0 0 0 0 3.618616138 3.114257723 3.110114803 1.096171746 0.476582042 1.008872696 0 0 0 0 0 0 0 0 0 0 0 0 0.82990634 0.617235541 0.554036952 0.948088079 0.935726693 0.724163735 C16 Ceramide m+8 0 0 0 0 0 0 0 0 0 0 0 0 3.455447185 2.765186223 2.568072767 2.584260304 3.1820606 2.275599339 0 0 0 0 0 0 0 2.037118775 0 0 0 0 9.603044828 9.959198697 10.29091283 2.954184331 2.647057219 2.72331765 0 0 0 0 0 0 2.774605392 2.015600731 2.507710476 0 0 0 1.444859598 2.261233454 1.913335718 2.068473523 2.224813727 2.247288592 C16 Ceramide m+9 0 0 0 0 0 0 0 0 0 0 0 0 0.16290457 0.4613648 0.944806188 0.641074554 0.26289121 0.333678451 0 0 0 0 0 0 0 0 0 0 0 0 2.971617121 3.341925171 3.87279499 0.596197245 0.696612408 0.240009571 0 0 0 0 0 0 0 0.525471954 0 0 0 0 0.602982188 0.426526562 0.314922807 0.215224586 0.588777953 0.376140754 C16 Ceramide m+10 0 0 0 0 0 0 0 0 0 0 0 0 1.708015995 0.975989985 1.086802785 1.008246208 1.017629768 1.508351476 0 0 0 0 0 0 0 0 0 0 0 0 7.181135166 7.458010598 6.482431991 1.358188983 0.732714501 1.58068756 0 0 0 0 0 0 3.876059925 3.738951249 4.173604298 0 0 0 1.121668505 1.044405021 1.026205034 0.787200061 0.761432209 1.293002549 C16 Ceramide m+11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.29518779 0 0 0 0 1.805504723 2.630083699 1.379726595 0 0 0 0 0 0 0 0 0 1.134077584 0.577401797 0.801510111 0 1.91143199 0 0 0 0 0 0 0 C16 Ceramide m+12 0 0 0 0 0 0 0 0 0 8.070474203 8.134711549 8.538339375 0 0 0 0 0 0 0 0 0 0 0 0 6.980579171 1.596769499 6.838464914 7.595631584 6.976563861 7.904535718 2.795910313 0 2.476447811 0 0 0 0 0 0 0 0 0 4.900840543 5.050632026 5.699878641 5.936842492 5.370503028 6.218040469 0 0 0 0 0 0 C16 Ceramide m+13 0 0 0 0 0 0 0 0 0 0.863917711 0 0.527543094 0 0 0 0 0 0 0 0 0 0 0 0 1.778713744 2.136313496 1.564193948 1.650760131 1.909473132 0.967252915 0 0 0 0 0 0 0 0 0 0 0 0 0.613520034 0.469403572 0.099347285 0.929897948 0.405281324 0.616703118 0 0 0 0 0 0 C16 Ceramide m+14 0 0 0 0 0 0 10.88012365 0 11.19531341 7.067794625 7.475564139 6.753683442 0 0 0 0 0 0 0 0 0 0 0 0 7.335803963 3.215069126 7.84679886 8.240228735 7.11397714 8.976689718 0 0 0 0 0 0 0 0 0 0 0 0 5.401452292 5.65741631 6.191752433 6.180418267 5.625169999 6.711226297 0 0 0 0 0 0 C16 Ceramide m+15 0 0 0 0 0 0 0 2.694568987 0.325579438 0.262004522 0 0.532248697 0 0 0 0 0 0 0 0 0 0 0 0 1.179025123 1.283506334 0.598846078 1.037347955 1.490497201 0.218424793 0 0 0 0 0 0 0 0 0 0 0 0 0.460441659 0.335276292 0.477110565 0.411932645 0 0 0 0 0 0 0 0 C16 Ceramide m+16 0 0 0.167470292 0.182921833 0 0 5.020527006 5.809564088 5.162246075 3.913693497 3.693532192 3.807422699 0 0 0 0 0 0 0 0 0 0 0 0 4.110212937 5.577721423 5.266210408 5.214519659 4.259580762 5.131667836 0 0 0 0 0 0 0 0 0 0.082408902 0 0 3.063811223 3.313632201 3.116908626 3.425291114 3.953858226 3.749136191 0 0 0 0 0 0 C16 Ceramide m+17 0 0 0 0 0 0 0.20678351 0 0.169797347 0.14532319 0 0.064912998 0 0 0 0 0 0 0 0 0 0 0 0 0 0.575848793 0 0 0.509898546 0.070102116 0 0 0 0 0 0 0 0 0 0 0 0 0 0.15159829 0.081462527 0.04667188 0 0.010836059 0 0 0 0 0 0 C16 Ceramide m+18 0 0 0 0 0 0 0.952042669 1.452038396 0.630094832 0.988854332 1.318208343 1.166709722 0 0 0 0 0 0 0 0 0 0 0 0 0.506297083 4.492044152 0.678434555 0 0 0.736302558 0 0 0 0 0 0 0 0 0 0 0 0 1.020905864 0.725808879 1.038340036 0.583044913 0.728898978 0.842811878 0 0 0 0 0 0 C16 Ceramide m+19 0 0 0 0 0 0 0.206604074 0 0.371390134 0.163848023 0.288659499 0 0 0 0 0 0 0 0 0 0 0 0 0 0.406572803 0 0 0.291332242 0.434781073 0.286292773 0 0 0 0 0 0 0 0 0 0 0 0 0.004090018 0.076655679 0 0.062003174 0.188455883 0.162740617 0 0 0 0 0 0 C16 Ceramide m+20 0 0 0 0 0 0 2.206206394 2.658854946 1.657984458 1.950099862 1.684778565 2.005915068 0 0 0 0 0 0 0 0 0 0 0 0 0.949727764 2.05639193 0.961743839 0.842570747 0.89502563 0.991360922 0 0 0 0 0 0 0 0.052345818 0 0 0 0 1.504534328 1.67883106 1.714558083 1.538998653 1.593158012 1.434721425 0 0 0 0 0 0 C16 Ceramide m+21 0 0 0 0 0 0 1.872427844 1.667856799 1.653319138 0.888030802 1.267364854 1.215531969 0 0 0 0 0 0 0 0 0 0 0 0 0.755948992 0 0.974658397 0.856712872 0.814188663 0.559154913 0 0 0 0 0 0 0 0 0 0 0 0 1.454585527 1.189314492 1.296698652 1.328751062 1.471013784 1.207586889 0 0 0 0 0 0 C16 Ceramide m+22 0 0 0 0 0 0 4.877650007 4.24865962 4.190643857 0 4.614251463 0 0 0 0 0 0 0 0 0 0 0 0 0 2.911394039 2.88109128 0 1.829926838 1.967916825 0 0 0 0 0 0 0 0 0 0 0 0 0 2.801968772 3.828952734 3.680677114 2.918344407 3.774800851 2.898176172 0 0 0 0 0 0 C16 Ceramide m+23 0 0 0 0 0 0 2.620001112 2.152434182 2.692597446 3.630350694 2.523816143 2.91933914 0 0 0 0 0 0 0 0 0 0 0 0 1.885257339 2.109283929 2.23868053 1.953384705 1.413664135 2.439864826 0 0 0 0 0 0 0 0 0 0 0 0 3.002938897 2.363457091 2.711380748 2.830857175 2.801116994 2.470279204 0 0 0 0 0 0 C16 Ceramide m+24 0 0 0 0 0 0 5.238178162 5.142025392 4.918242218 4.645848899 4.658178753 5.291916693 0 0 0 0 0 0 0 0 0 0 0 0 3.687329002 3.343886613 3.253833095 2.979976992 3.814918128 3.588751324 0 0 0 0 0 0 0 0 0 0.152765661 0 0 4.135289852 3.959598002 4.104021052 4.365694295 4.669929386 4.117315227 0 0 0 0 0 0 C16 Ceramide m+25 0 0 0 0 0 0 4.112150444 3.758435913 3.366385764 3.028481226 3.517472265 3.362402021 0 0 0 0 0 0 0 0 0 0 0 0 2.704100711 3.900524085 2.745445136 2.294861611 2.362487963 2.660037246 0 0 0 0 0 0 0 0 0 0 0 0 2.460935472 2.698601316 2.778704067 2.848282332 3.056079963 3.199241629 0 0 0 0 0 0 C16 Ceramide m+26 0.131127437 7.39368296 0 0 0.400742446 0 6.147721678 6.799932468 4.861138025 4.778865922 6.112254753 5.108286238 0 0.464905554 0.838796209 0 0 0 0 0 0 0 0 0.697179842 4.186393183 8.115443687 4.738817304 4.235992458 4.449729719 5.922650996 2.89451646 2.122815279 2.06884899 0 1.467999223 0 0 0 0 0 0 0 4.911140856 5.051101246 5.141399295 5.379501649 5.659059405 5.643029507 0 0 0 0 0.580577916 0 C16 Ceramide m+27 0.439281468 1.141283533 0 0 0 0 3.017124351 3.566627686 3.970481113 3.524350704 2.800637068 3.80043856 0 0 0 0 0 0 0 0.428911252 0 0.813904696 0 0 2.729269898 5.360584423 3.267940075 3.105064732 2.960726168 3.020602792 0 0.593699199 1.658690689 0.194672977 0 0 0 0.168249734 0 0 0 0.176722201 2.49078568 2.521082232 2.36298076 3.08566632 3.14596385 3.047748156 0 0 0 0 0 0 C16 Ceramide m+28 0 18.2805818 0 0 0 0 5.64021424 5.199798486 5.391294409 5.486087687 5.416957133 4.909860901 0 0 0 0 0 0 0 0 0 10.09902636 0 0 5.870292165 9.481368169 5.490365659 5.472007202 5.259812438 6.024917052 5.327958655 4.441774155 4.900185726 0 0 0 0.623526563 0.701355559 1.188258826 0.704310882 0 0.965637702 4.487705807 4.991616886 4.085307607 5.049552176 5.200712923 6.108860035 0.965878834 1.001289464 0.968971527 1.384816549 1.270042464 1.187957903 C16 Ceramide m+29 0 9.965382515 0 0 0 0 2.131820809 3.115863545 2.163830239 3.05360297 3.365053535 1.852383467 0 0 0 0 0 0 0 0 0 0 0 0 2.211660001 7.453895633 1.709625262 1.918686559 2.107080136 2.648983439 2.045016915 0 1.769986381 0 0 0 0 0.322957163 0.363079936 0 0 0 1.93574297 1.89468465 1.807440463 2.393528028 2.163740953 2.330528342 0.401978113 0.20516251 0.325983604 0.469655525 0.506018849 0.492017805 C16 Ceramide m+30 0 0 0 0 0 0 3.491251706 3.665539722 3.079226084 3.049026414 2.873240642 3.219079167 0.534844541 0 0 0 0 0 0 0 0 1.455125946 0.249869831 0 2.788269264 9.661354008 3.404274989 3.74939355 3.64900942 3.936049313 0.193644977 1.262361366 1.249045567 0.539007868 0.685851894 0.713066878 0 0 0.166421155 0.120153536 0 0.124350609 2.806415557 2.688947687 2.202486666 3.846936497 3.537607102 3.526949376 0 0 0 0 0.302045405 0 C16 Ceramide m+31 0 0 0 0 0 0 0.844887086 1.112108703 0.947982344 0.80636963 0.682702131 0.564821975 0 0 0 0 0 0 0 0 0 0 0 0 0.594999276 4.249856302 1.143082978 0.911414223 1.114676413 1.217075193 0 0 0 0 0 0.133882126 0 0 0.068732211 0 0 0 0.496734737 0.582760057 0.440890208 1.13838843 1.00433653 0.873886291 0 0 0 0 0 0 C16 Ceramide m+32 0 0 0 0 0 0 0.852659767 0 1.267549732 0.632787911 0 1.194029558 0 0 0 0 0 0 0 0 0 0 0 0 0.693873271 6.343499874 0.946150011 1.430724869 0.969113748 0.797159647 0 0 0 0 0 0 0 0 0 0 0 0 0.789005447 0.679047448 0.641416764 1.280810741 0.755625205 1.38904539 0 0 0 0 0 0 C16 Ceramide m+33 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.942963596 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C16 Ceramide m+34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.491605047 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.106194578 0 C18_1 ceramide m0 94.62261394 97.06317525 5.518033202 15.01056317 1.07839627 5.753520278 8.143445343 9.734771697 10.30808851 9.143319518 9.668989961 9.846354432 25.23680945 25.96292654 25.53263915 28.00480384 28.15417998 29.68825148 88.36036013 83.82953632 92.3902511 92.37934171 93.09937092 90.38828371 12.49323436 11.35500585 11.79859552 11.98566208 9.377904641 11.29169677 32.03279779 35.41882591 30.21703973 32.63694044 0 0 16.03027446 16.16221686 18.15073033 21.97993439 96.74373253 94.32856786 99.12696948 94.69622067 14.06636083 9.870764323 11.05429287 9.634358692 3.131578921 100 100 100 100 95.11030438 C18_1 ceramide m+1 0 0 0 0 0 0 2.908417668 3.488176447 3.3256761 2.923448241 3.487358144 2.841626329 20.48866719 19.36159983 19.64255822 19.78150856 20.74047894 15.84970574 0 0 0 0 0 0 4.151106134 5.536954573 4.985418361 5.542806531 7.140339941 4.5371751 26.87628048 15.63859695 24.86759688 0 0 0 0 0 0 0 0 0 0.873030517 0 2.875221839 2.872984981 2.746852039 3.109849519 6.294403014 0 0 0 0 0 C18_1 ceramide M+2 2.369592673 2.936824751 93.60387178 0 95.97400035 89.33990552 10.1409354 9.796057555 9.55926982 12.51263948 11.76095364 11.70259331 0 0 0 0 0 0 8.936018042 8.783530267 0 7.620658291 6.900629084 0 13.27967388 15.79844222 14.24962542 16.48661528 13.3177543 13.89683938 14.47353786 10.99244332 6.179547592 20.62014467 51.99401711 42.83630891 80.69203695 81.09447923 74.44829946 72.13680285 0 0 0 0 11.69482659 8.924157334 9.301899604 9.016910829 66.83622911 0 0 0 0 0 C18_1 ceramide m+3 1.709792775 0 0.878095021 84.98943683 2.026098665 1.540669602 0.974215064 2.000658797 0.643059094 0.752309173 1.782949116 1.539943275 29.6483503 32.16285066 29.80175763 31.93457595 32.71193235 32.84946298 2.703621824 0 5.400581859 0 0 5.519264703 0.300211347 0.856711883 1.264443652 0.456074135 1.705966161 0.753169486 10.58792637 16.5993414 22.33512025 20.47035275 37.56197167 27.4926368 1.834397032 2.367562582 7.352315079 2.614805874 0 0 0 0 1.31437836 1.223431453 1.319939445 1.153912091 10.4873923 0 0 0 0 0 C18_1 ceramide m+4 0 0 0 0 0.044233124 1.258211999 3.670929012 5.713911895 6.615897333 3.780176069 3.164598724 3.510132783 2.425270365 2.57048878 3.427641297 4.16140642 4.534345111 3.731839964 0 0 0 0 0 0 4.82580739 6.362405503 5.78042429 6.895447357 4.408328949 5.842614315 5.775635146 3.683683576 0.798217433 6.81745761 10.44401123 13.14538052 0 0 0 0 0 0 0 0 8.446175218 6.52365594 7.653118547 6.439894834 0.36372491 0 0 0 0 0 C18_1 ceramide m+5 0 0 0 0 0.877271593 0 0.227080283 0 0.206163889 0.489623578 1.117309242 0.949397054 12.60832865 12.65881277 9.260440944 10.38296812 9.463908624 11.9248864 0 0 0 0 0 0 0.176113256 0 0 0 0.256851803 0 6.203755479 10.51749055 10.47807995 11.8091283 0 16.52567377 0 0.375741329 0.048655131 0.770078911 0 0 0 0 0.752765584 0.307598346 0.320480103 0.216504451 7.454028364 0 0 0 0 0 C18_1 ceramide m+6 0 0 0 0 0 0 1.918378338 2.345114743 2.399873907 2.61946948 2.390187487 2.017206329 3.825554585 1.987184095 2.651601394 2.781553434 0 1.439528782 0 0 0 0 0 0 1.429486124 1.63773196 1.832994668 1.385702753 1.643083466 1.109167811 0 0 0 0 0 0 0 0 0 0 0 0 0 5.303779333 0 2.94328339 2.445696427 2.877499029 0 0 0 0 0 0 C18_1 ceramide m+7 0 0 0 0 0 0 1.597850244 2.037098338 1.506448584 1.608984048 2.202027828 1.807951416 5.767019459 5.296137325 6.037239457 2.953183671 4.395155 4.51632465 0 0 0 0 0 0 1.282303503 1.460824708 1.504714282 1.064519072 0.874270093 1.760306325 0 4.960428092 0 0 0 0 0 0 0 0 0 0 0 0 2.435575939 0.736323538 2.197833842 1.748619531 3.641099212 0 0 0 0 0 C18_1 ceramide m+8 0 0 0 0 0 0 0 0 0 2.585076851 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.86542351 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.791544164 0 0 0 0 0 C18_1 ceramide m+9 0 0 0 0 0 0 4.777820618 4.899327762 4.419434262 3.907413431 4.342699075 5.665945191 0 0 3.646121907 0 0 0 0 0 0 0 0 0 2.701504052 4.266144049 3.59627895 3.094222042 0 3.366231494 4.050066879 0 5.124398165 7.645976232 0 0 0 0 0 0 0 0 0 0 4.054659102 4.32120121 4.466703713 2.806736011 0 0 0 0 0 4.889695624 C18_1 ceramide m+10 0 0 0 0 0 0 4.527111058 1.064188338 2.863428035 4.478869538 7.671973818 5.060166065 0 0 0 0 0 0 0 0 0 0 0 0 5.229022652 3.353204592 1.159738449 4.450410926 7.55466132 4.781107392 0 2.189190209 0 0 0 0 0 0 0 0 0 0 0 0 0 3.310295735 2.976104711 3.881362373 0 0 0 0 0 0 C18_1 ceramide m+11 0 0 0 0 0 0 4.277959809 7.639924531 7.546730782 4.164682217 5.361038134 3.707793682 0 0 0 0 0 0 0 0 0 0 0 0 5.005771043 4.946123051 5.273221974 3.523215901 3.404603503 4.75688777 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.667992033 3.547842324 3.980093633 3.3584118 0 0 0 0 0 0 C18_1 ceramide m+12 0 0 0 0 0 0 8.057080071 5.47083229 5.829566392 8.463879236 8.176798479 8.332439103 0 0 0 0 0 0 0 0 0 0 0 0 5.167860787 6.414312537 8.53347843 7.416043865 8.124015176 7.527942373 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9.61662229 8.338318056 9.097148611 7.994315009 0 0 0 0 0 0 C18_1 ceramide m+13 0 0 0 0 0 0 5.515511374 5.272033998 4.993204753 4.535063339 3.634476273 4.58370594 0 0 0 0 0 0 0 0 0 0 0 0 6.196248742 0 3.980965375 4.450605135 3.966349639 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.352110788 2.758463358 2.200810634 1.498417432 0 0 0 0 0 0 C18_1 ceramide m+14 0 0 0 0 0 0 12.70766287 10.12127283 10.66345224 11.09065731 11.86752454 11.16396455 0 0 0 0 0 0 0 0 0 0 0 0 9.365376965 10.70048752 10.68041418 6.898518855 12.86476935 12.45656675 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11.55011479 10.44459858 11.02413492 11.70379078 0 0 0 0 0 0 C18_1 ceramide m+15 0 0 0 0 0 0 3.728368475 3.981159876 3.732999551 3.404352181 2.784486848 3.95930124 0 0 0 0 0 0 0 0 0 0 0 0 4.451533475 5.01453242 3.921428286 6.869520388 3.225474559 4.261650559 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.199426145 3.579933626 3.296791607 2.668293012 0 0 0 0 0 0 C18_1 ceramide m+16 0 0 0 0 0 0 13.28648264 12.90282447 11.88912445 11.70611446 10.3828275 11.22512261 0 0 0 0 0 0 0 0 0 0 0 0 10.36782428 9.378142927 9.686745342 8.306751405 9.274408989 10.21725031 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12.10373938 12.67249666 12.35256539 12.78855861 0 0 0 0 0 0 C18_1 ceramide m+17 0 0 0 0 0 0 1.585874682 1.099925259 1.924314782 0.63438328 0.724772592 1.12816836 0 0 0 0 0 0 0 0 0 0 0 0 2.576295647 2.073050656 2.693558938 1.992380384 1.820774098 2.35617625 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.892569017 1.362783357 1.552952662 1.221496965 0 0 0 0 0 0 C18_1 ceramide m+18 0 0 0 0 0 0 9.084519854 9.380696371 8.526702678 7.607434863 6.471561718 7.472713968 0 0 0 0 0 0 0 0 0 0 0 0 6.690902448 7.501504924 6.590732924 6.573736322 7.264281522 7.550222197 0 0 0 0 0 0 1.443291553 0 0 1.211703447 0 0 0 0 9.884164884 9.732974548 10.67110219 10.95693775 0 0 0 0 0 0 C18_1 ceramide m+19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.755422138 0 0.403673438 0.595609183 0 0.416125118 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.093297214 0.505384115 1.341479051 0.72165831 0 0 0 0 0 0 C18_1 ceramide m+20 0 0 0 0 0 0 2.870357191 3.052024804 3.04656484 3.592103708 3.007466875 3.485474365 0 0 0 0 0 0 0 0 0 0 0 0 1.688878267 3.344420622 2.063547522 2.012158382 3.776162488 3.1188706 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.023509133 0 6.202472973 0 0 0 0 0 0 C18_1 ceramide m+21 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+25 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+26 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+27 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+28 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+29 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.286674534 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+30 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.634188277 2.209167037 0 0 4.092451584 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.256267467 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+31 0 0 0 0 0 2.107692602 0 0 0 0 0 0 0 0 0 0 0 0 0 3.752745133 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+32 1.298000611 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+33 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.671432143 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+35 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18_1 ceramide m+36 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m0 95.52632919 95.96690272 95.72572301 95.13330289 96.66771767 94.2324081 12.4369578 12.87878842 12.66113815 15.78135634 16.3199676 16.13921655 25.24710791 25.72444934 28.80528485 28.47171453 25.4901816 30.25177936 98.11616082 89.7141346 97.01140452 88.18396884 94.22007724 93.70163943 20.3999855 20.69583044 18.86323016 19.70420223 17.68269734 18.3930787 30.08720675 33.96563972 28.60587324 41.99280221 34.75682298 37.54593336 97.95079843 99.25853728 92.74082591 96.840116 94.19995986 90.43519149 8.779770052 8.7599279 8.41464851 6.598039395 7.041666547 7.601410149 32.18299585 35.45585473 30.76201387 32.57146643 32.76034301 30.69142587 C18 ceramide m+1 2.771776336 4.033097278 2.906589754 0.335862157 0.28369556 4.338437979 0.351781626 0.373163592 0.294225007 1.072073738 1.02764873 0.657489788 26.62581108 27.16030296 27.45919732 26.99045172 30.16634405 25.93717446 0 0.917741552 0 5.864560347 0 0 0.155524212 0 1.733749723 0 0.972832241 0.319313952 24.13087609 20.91009968 26.24843771 17.23402137 29.02966811 37.71315012 0.700205282 0 6.876899268 2.388214256 3.554272064 6.507093818 3.055315974 2.416958948 2.551292833 2.350868468 2.628255523 2.725712072 27.36354751 23.38949558 28.68957557 25.0902756 26.12013287 25.47049436 C18 ceramide M+2 1.701894477 0 0 1.321460585 0 0 3.967213056 4.421264092 4.156318132 3.87581776 4.510571961 4.082970278 7.031068779 7.346209331 7.486255966 5.053009649 3.154589673 5.022334633 0 0.693292291 0 0 0 2.308185359 5.579109089 6.558181395 5.660649271 4.362750286 5.238612344 5.951896651 5.516197874 15.03431445 6.922806149 11.71690293 20.52868527 9.054918829 0.80765534 0 0 0 0.589719645 0 4.414975488 4.432727326 4.713761561 0 3.566037426 0 4.809925694 8.012226961 6.181371322 8.174770788 5.538506671 6.930875758 C18 ceramide m+3 0 0 0 1.430699696 1.139045077 0 0.274125476 0.200709929 0.394455079 0.39205434 0.937204268 0.951114435 20.53579909 19.09154012 17.6048261 20.13632138 21.1410186 18.85048923 1.883839177 2.123619475 0 0 0 0.862595998 0 0 0 0 0.027573579 0 19.53598973 21.43165783 19.24826517 13.77436 15.68482364 13.15494201 0.541340949 0.741462723 0.382274822 0.771669742 0 0 1.118714909 1.144030057 0.78205485 2.461633071 1.030896584 0 18.48710002 17.48011356 17.23888641 17.77950399 18.21936552 19.77477464 C18 ceramide m+4 0 0 0 0 0 0 2.015525248 1.767990954 1.551335851 2.276958653 1.719506317 2.122460482 2.320329276 4.055814365 3.42148231 3.077751046 1.685387514 4.158075982 0 0 0 0 0 0 1.804502688 0.829183722 1.637085249 1.450428495 1.563239351 1.391928161 2.318081049 0 2.983422676 0 0 0 0 0 0 0 0 0 0 4.101311172 4.36043733 4.025457665 3.781504846 0 3.143131672 1.788659693 3.74706707 3.938374827 3.374029803 1.710694012 C18 ceramide m+5 0 0 0 0 0 0 1.854953565 1.666527604 1.883978368 2.278070328 3.291555362 2.376980832 11.50499614 10.5635505 9.877518128 9.984409608 11.81413668 9.63704141 0 0 0 2.459394893 0 0 1.329378672 1.848668494 1.711141657 1.341828891 0.911151289 1.129108904 11.29644372 8.658288316 10.11416378 0 0 0 0 0 0 0 0 0 2.35454653 1.032214147 0.579042873 0.444957906 0.579986589 1.864566673 8.571899981 8.633987113 8.198872273 7.447602183 8.362988171 10.0527019 C18 ceramide m+6 0 0 0 0 0 0 0 3.085671858 2.710787447 0 0 0 1.042244405 0.795149913 0.856509353 2.116683403 1.222562162 1.987485831 0 0 0 0 0 0 0 0 0 0 0 1.235846798 1.368424823 0 0.905006304 6.249086626 0 0 0 0 0 0 0 0 2.420471315 2.252849174 2.911587194 2.170683983 2.221308216 2.254088815 2.363194754 1.681953656 1.886516742 1.869958593 2.483898141 2.274262569 C18 ceramide m+7 0 0 0 0 0 0 5.073535098 3.214842525 3.491187901 5.372398223 5.923418464 6.068198191 5.692643319 5.262983456 4.488925979 4.169658666 5.325779721 4.155619093 0 0 0 0 0 0 4.763406662 0 0 3.846594018 4.021895438 4.070797653 5.746779962 0 4.972024962 5.565344609 0 0 0 0 0 0 0 0 2.256998992 1.768458841 2.82213764 2.749117163 1.670029632 1.759419294 3.078204526 3.557708707 3.295696745 3.12804759 3.140735816 3.094770893 C18 ceramide m+8 0 0 0 0 0 0 6.930769039 6.189114021 5.354360839 7.631071155 8.294879049 7.538987732 0 0 0 0 0 0 0 0 0 0 0 0 4.382295293 8.311552784 7.828862471 4.987790745 5.439644432 5.402589189 0 0 0 0 0 0 0 0 0 0 0 0 4.172335488 5.73220128 4.723195508 3.087095491 4.151707662 3.993404215 0 0 0 0 0 0 C18 ceramide m+9 0 0 0 0 0 0 4.836123791 5.384381541 6.470578362 6.088794781 5.77928941 6.570471542 0 0 0 0 0 0 0 0 0 0 0 0 6.15340382 5.279062143 5.103844851 5.221283497 5.020427029 4.858715943 0 0 0 0 0 0 0 0 0 0 0 0 5.375079784 3.703613294 3.674107145 4.39892455 5.026305732 3.680165418 0 0 0 0 0 0 C18 ceramide m+10 0 0 0 0 0 0 9.104576861 7.316467227 6.994225918 8.860716405 10.3379699 8.476828849 0 0 0 0 0 0 0 0 0 0 0 0 8.90480987 9.809662474 9.208419811 8.525916206 9.400990629 9.616766262 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+11 0 0 0 0 0 0 6.373553773 6.992120402 6.612494484 5.061655911 4.186967418 5.491555909 0 0 0 0 0 0 0 0 0 0 0 0 6.697791096 6.306643498 5.853917862 7.257693775 6.319314062 6.715144102 0 0 0 0 0 0 0 0 0 0 0 0 7.683397658 8.949974481 7.511615541 8.406757883 7.801030595 8.017808835 0 0 0 0 0 0 C18 ceramide m+12 0 0 0 0 0 0 13.50118184 13.63501182 14.03004722 12.35216383 13.61703856 12.6134631 0 0 0 0 0 0 0 0 0 0 0 0 12.2297635 12.82984264 13.60703202 11.52052437 13.44124992 12.90231076 0 0 0 0 0 0 0 0 0 0 0 0 12.61306692 11.32616173 12.22338256 12.91650959 12.43148797 13.08955261 0 0 0 0 0 0 C18 ceramide m+13 0 0 0 0 0 0 4.171700269 3.628243674 4.445631483 3.892147993 3.027689285 4.41067593 0 0 0 0 0 0 0 0 0 0 0 0 4.683408939 5.600705535 4.900925194 6.440641928 4.667743843 5.208039958 0 0 0 0 0 0 0 0 0 0 0 0 4.336596648 4.710974434 4.534907171 3.274846925 5.048714331 5.580349641 0 0 0 0 0 0 C18 ceramide m+14 0 0 0 0 0 0 14.39560245 14.29886157 13.41750443 12.55127541 11.99018336 12.48137709 0 0 0 0 0 0 0 0 0 0 0 0 12.91279987 10.54231379 10.83473644 9.717113434 12.26492129 10.89842572 0 0 0 0 0 0 0 0 0 0 0 0 14.94335569 14.27676963 14.20869296 16.46309199 14.74248313 16.11608526 0 0 0 0 0 0 C18 ceramide m+15 0 0 0 0 0 0 1.598812388 1.466046112 2.482791291 0.922987508 1.759008319 1.120134941 0 0 0 0 0 0 0 0 0 0 0 0 1.51751487 2.307530855 3.11543314 3.328441944 3.460105736 3.482810833 0 0 0 0 0 0 0 0 0 0 0 0 2.92082175 2.138153854 2.86500095 4.330705681 3.34822788 4.100366881 0 0 0 0 0 0 C18 ceramide m+16 0 0 0 0 0 0 9.678480683 9.708158952 9.704827603 7.947330453 7.101456076 8.073136906 0 0 0 0 0 0 0 0 0 0 0 0 7.47397817 8.941199802 9.565855824 8.942864249 8.565561762 7.599408602 0 0 0 0 0 0 0 0 0 0 0 0 12.87172893 11.96335985 10.90880319 15.02958529 12.36620536 14.27600106 0 0 0 0 0 0 C18 ceramide m+17 0 0 0 0 0 0 0 0.581472549 0 0 0.17564592 0.824937447 0 0 0 0 0 0 0 3.529501399 0 0 0 0 1.012327743 0.139622432 0.375116331 0.083337865 1.002039717 0.82381781 0 0 0 0 0 0 0 0 0 0 0 0 1.923190825 1.894491335 1.365273767 0.890069364 2.664291918 2.917684739 0 0 0 0 0 0 C18 ceramide m+18 0 0 0 0 0 0 3.435107038 3.191163159 3.344112439 3.643127178 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.26858807 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.738925204 5.299450809 6.897995176 7.055108245 5.146898432 6.163378715 0 0 0 0 0 0 C18 ceramide m+19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.121178621 0.657157942 0.146420684 0 0.444470297 0 0 0 0 0 0 0 C18 ceramide m+20 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.899529227 3.439213795 3.805642558 3.346547334 4.308491334 5.860005613 0 0 0 0 0 0 C18 ceramide m+21 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+25 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.021710686 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+26 0 0 0 1.77867467 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.656048428 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+27 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+28 0 0 0 0 1.909541696 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.492075919 0 0 0 0 0 0 0 0 0 0 0 3.467482266 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+29 0 0 1.367687232 0 0 1.429153923 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+30 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+31 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+32 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+33 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.127579217 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.531055674 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+35 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.988595475 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C18 ceramide m+36 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.779922758 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.057714693 0 0 0 0 0 0 0 0 0 0 0 0 C20 ceramide m0 81.54563267 83.84658598 81.77347576 78.51193825 83.45716252 82.89235735 12.84366621 12.57521875 12.53941261 15.45408701 16.25661914 14.78919441 20.73951736 26.16333074 25.23280059 25.66256177 20.70784108 21.82708711 82.908163 67.5649671 72.29792701 ND 72.35416598 69.86022287 22.02530529 20.50311884 20.88266407 20.36960882 20.15323327 18.56407988 24.34784008 18.73020307 24.65826214 26.17985731 28.03574015 29.49467345 75.57976117 81.00596899 80.42248666 80.6517702 80.181266 78.61786201 23.29325806 24.28833467 23.9340271 19.30880311 20.62297671 18.95976384 33.26907523 29.94930816 32.15301986 33.81983294 30.91626696 27.14255171 C20 ceramide m+1 0 0 0 0 0 0 1.604647054 1.945491491 1.947915045 1.532850571 1.712599507 1.775294859 23.27708318 23.12382986 22.57667921 21.11226464 22.86982614 24.87769869 0 0 0 ND 0 0 3.030975938 2.675231341 2.886003497 3.448360408 2.179035827 2.783233467 19.70980798 26.00408763 29.14092635 26.95647207 31.2742281 29.76226722 0 0 0 0 0 0 1.890836356 1.766813911 1.829061173 2.215633169 1.857102739 2.526878984 20.66595978 25.31839826 21.94446899 21.11510653 22.16240162 21.78854012 C20 ceramide M+2 0 0 0 0 0 0 8.612782878 8.777147486 8.614804858 8.768338247 8.976008032 8.751082967 6.627215689 0 0 0 9.985090221 13.1397921 0 0 0 ND 0 0 12.36360105 12.23709499 12.46850487 12.50665109 12.17892847 11.33174877 9.885049229 14.02883158 12.63772184 11.57800291 14.99054244 11.03786314 0 0 0 0 0 0 11.5722502 11.92850435 11.82310906 10.61073272 10.05030002 10.04473332 0 0 0 0 0 0 C20 ceramide m+3 0 0 0 0 0 0 0 0 0 0 0 0 22.03939783 26.3027418 27.44849091 29.40164499 19.33469028 17.98566454 0 0 0 ND 0 0 0 0 0 0 0 0 19.35307725 20.79310224 19.28407374 19.6721627 21.61010324 21.57280657 0 0 0 0 0 0 0 0 0 0 0 0 25.52148732 25.57360556 26.38140179 26.76325865 25.33554393 29.86223785 C20 ceramide m+4 15.42287253 16.15341402 16.70580175 20.6530096 16.54283748 17.10764265 3.859660189 4.01224702 3.938221317 3.981397104 4.316432432 4.058657659 1.097764002 2.298155645 0 0.724592169 2.729106838 3.239062082 0 28.19152933 19.945643 ND 27.64583402 27.48533734 4.874404334 4.435814762 4.720425422 4.95539305 4.225167459 4.362494569 3.463936469 9.589239965 1.360757044 5.952593376 4.089386075 0.100601608 21.71304266 15.90056027 9.505626052 15.31978273 18.57451178 18.28784859 4.195899411 4.460671705 4.465952642 4.379724947 3.60523303 3.82379231 0 0 0 0 0 4.91145525 C20 ceramide m+5 0.121834563 0 1.520722492 0.835052153 0 0 0.436262999 0.271756275 0.246465393 0.609018725 0.959405998 0.650606793 14.18334009 14.78476042 15.46187569 14.12644737 15.30114227 12.08897367 17.091837 4.243503563 3.527602469 ND 0 2.654439787 0.579341828 0 0 0 0 0.035010852 14.41859656 10.85453551 0 0 0 8.031788011 2.707196165 3.093470746 6.733191829 4.028447071 1.244222219 3.0942894 0.576464202 0.780644914 0.914891785 0.634159441 1.120759848 0.639838987 13.2092291 13.02586985 14.45782965 12.30575079 15.428894 10.27457168 C20 ceramide m+6 0 0 0 0 0 0 1.969205121 1.949129166 1.951685862 0 0 0 3.910355821 0 3.625907144 0 0 0 0 0 0 ND 0 0 0 0 0 0 0 0 0.303546825 0 5.991371706 0 0 0 0 0 0.371125169 0 0 0 2.481947629 2.646143001 2.219642142 2.009950867 2.146178858 2.332506057 1.370916729 1.649095723 1.463665243 3.145035471 2.145230253 2.459171324 C20 ceramide m+7 0 0 0 0 0 0 1.803811571 1.283605114 1.49963912 3.129764498 3.485702032 3.33808941 8.125326035 7.327181533 5.654246459 8.972489059 9.072303167 6.841721804 0 0 0 ND 0 0 0 2.596956113 0 0 0 0 8.51814561 0 6.926887193 9.660911642 0 0 0 0 0 0 0 0 2.746251571 2.757162124 3.138295054 2.373840695 2.552019648 2.030007655 5.963331835 4.483722445 3.59961447 2.851015612 4.011663241 3.561472065 C20 ceramide m+8 0 0 0 0 0 0 3.605999355 3.871054731 3.279219208 4.065811713 4.754218968 3.99748552 0 0 0 0 0 0 0 0 0 ND 0 0 0 2.492971121 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C20 ceramide m+9 0 0 0 0 0 0 3.472228626 3.052619783 3.600076933 3.09507132 4.509505286 3.344368851 0 0 0 0 0 0 0 0 0 ND 0 0 0 3.119957293 0 4.273476089 4.341697638 5.124470067 0 0 0 0 0 0 0 0 0 0 0 0 4.985721794 0 0 0 5.542446849 5.717991903 0 0 0 0 0 0 C20 ceramide m+10 0 0 0 0 0 0 5.609583548 6.277063992 4.554758325 7.288558103 7.628881012 7.108918702 0 0 0 0 0 0 0 0 0 ND 0 0 7.846131862 5.348555669 7.458186945 5.157404429 4.990917084 4.965183221 0 0 0 0 0 0 0 0 0 0 0 0 5.960694602 8.427652747 9.031004949 8.213079852 6.110981103 5.55582516 0 0 0 0 0 0 C20 ceramide m+11 0 0 0 0 0 0 4.608836074 3.979276209 4.803813378 5.222904803 5.625034929 5.048869937 0 0 0 0 0 0 0 0 0 ND 0 0 5.32803647 4.77633823 5.135917943 0 4.902825638 5.42070523 0 0 0 0 0 0 0 0 0 0 0 0 4.958551967 4.979508862 4.522641085 4.445193996 5.267773987 5.527634576 0 0 0 0 0 0 C20 ceramide m+12 0 0 0 0 0 0 9.050646744 8.604676714 9.00008568 8.547942901 9.077597549 9.672812148 0 0 0 0 0 0 0 0 0 ND 0 0 9.032577291 8.088130784 10.12509 11.13935719 8.220273165 8.618782798 0 0 0 0 0 0 0 0 0 0 0 0 8.637835112 9.136830819 9.243503575 9.859703121 9.107787433 8.980124721 0 0 0 0 0 0 C20 ceramide m+13 0 0 0 0 0 0 4.613674273 4.620948587 4.705799808 4.762015274 3.834579219 4.304141307 0 0 0 0 0 0 0 0 0 ND 0 0 5.982125422 5.002395595 5.945825521 5.433531793 5.451814381 5.628818066 0 0 0 0 0 0 0 0 0 0 0 0 4.126967288 4.218279368 4.249020778 3.441534981 4.799865767 5.574864475 0 0 0 0 0 0 C20 ceramide m+14 0 0 0 0 0 0 11.78277098 11.52776191 11.69965322 11.44639507 11.25723451 11.08324405 0 0 0 0 0 0 0 0 0 ND 0 0 8.539046808 10.24433846 8.846753971 8.003219322 9.113043842 10.81411945 0 0 0 0 0 0 0 0 0 0 0 0 10.42307238 11.04698406 10.20244075 12.42291926 11.25671615 9.331024473 0 0 0 0 0 0 C20 ceramide m+15 0 0 0 0 0 0 3.26279651 3.440652198 3.414725733 2.671624624 1.964613818 2.623916945 0 0 0 0 0 0 0 0 0 ND 0 0 3.310124851 3.106616559 4.219823273 4.096271642 4.130438443 3.300149897 0 0 0 0 0 0 0 0 0 0 0 0 1.618577635 1.189776264 3.153790906 2.279579284 1.975087836 2.721893423 0 0 0 0 0 0 C20 ceramide m+16 0 0 0 0 0 0 11.6228003 11.41616209 12.03336152 10.34330094 9.633653168 9.934061682 0 0 0 0 0 0 0 0 0 ND 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0 1.39031275 0 1.29820572 1.560377704 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.873166733 0.862248269 1.092500886 1.374639045 1.366536139 1.634801049 0 0 0 0 0 0 C24_1 Ceramide m+36 0 0.130524392 0 0.12951006 0 0 0.685084545 1.624149805 6.469047204 2.926456096 2.825933476 3.604804438 0 0 0 0 0 0 0 0 0 0 0 0 2.472077953 0 1.882732542 2.746015295 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.294993551 1.006290288 1.486592724 2.201392609 1.461170754 2.860217239 0 0 0 0 0 0 C24_1 Ceramide m+37 0 0 0 0 0 0 0 0 0 0 0.057599504 0 0 0 0 0 0 0 0 0 0 0 0 0 0.892306537 0 0.735019724 1.073673517 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.179709486 0.546473169 0.250008747 0.991228038 1.10479766 0.824247999 0 0 0 0 0 0 C24_1 Ceramide m+38 0 0 0 0 0 0 0 2.970475158 0 0 0.430040693 0 0 0 0 0 0 0 0 0 0 0 0 0 1.592536752 0 1.104756818 1.370427901 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.098519791 1.466820173 1.245444094 0.35159818 0 0 0 0 0 0 C24_1 Ceramide m+39 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25151263 0 2.889081084 0 0 0 0 0 0 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58.02997877 35.84041126 34.84723948 C24 Ceramide m+1 0 1.583725058 1.186142744 2.977615745 0 0 0 1.024573085 2.777263144 0 1.613615544 1.07790584 0.053535461 0 1.231732092 5.196856918 2.004430299 2.243965757 0 1.455554792 0 0 1.341287342 1.309021409 1.199959408 2.559128047 3.984337883 2.38186045 2.346875671 1.257802543 1.31231275 0.046546479 4.963289058 1.683192792 2.534145908 0 0 0 0 0 0 0 0 0.595979138 0.135766577 0.684299342 0.498317587 0 1.202753741 1.343056796 1.453576472 1.04458111 2.092354687 1.545202722 C24 Ceramide M+2 0 0 0 0 0 0 17.82558076 21.21353185 5.735431611 0 9.837391609 11.14449281 12.78632774 12.38551299 12.4947463 19.796518 23.12177766 22.59825675 0 0 0 0 0 0 5.938470192 7.258110829 7.022008074 4.85887221 13.3983814 14.88790111 22.53605571 17.25639493 22.02037804 24.77231497 26.66762074 17.63482705 0 0 0 0 0 0 0 3.328532608 3.894917958 3.04413232 5.089326065 6.0647509 24.32102716 25.39033864 25.60778223 15.45029052 24.97729196 25.30985067 C24 Ceramide m+3 0 0 0 0 0 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Ceramide m+22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.301394991 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.606369714 5.003608795 4.585796687 5.450309572 5.075408353 5.553804893 0 0 0 0 0 0 C24 Ceramide m+23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.216673781 1.02054022 0 1.194240592 1.597785741 0.811771996 0 0 0 0 0 0 C24 Ceramide m+24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.224754709 0 0 2.217698707 0 0 0 0 0 0 C24 Ceramide m+25 0 0 0 0 0 0 0 0 0 1.582554825 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.322353599 1.276381073 0.903808425 0 0.849010458 0.909789785 0 0 0 0 0 0 C24 Ceramide m+26 0 0 0 0 0 0 0 0 0 1.461472836 2.028444185 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.437593026 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.389362667 1.579948427 1.788727763 0 0.954797446 0 0 0 0 0 0 0 C24 Ceramide m+27 0 0 0 0 0 0 0 0 0 1.354685465 1.448874453 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.127842697 1.758562694 1.477263262 0 1.200786104 0 0 0 0 0 0 0 C24 Ceramide m+28 0 0 0 0 0 0 0 0 0 2.591744554 3.476903145 2.232320519 0 0 0 0 0 0 0 0.071725115 0 0 0 0 0 0 0 1.791599178 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.031349461 3.260188634 0 0 3.295024145 2.245383829 0 0 0 0 0 0 C24 Ceramide m+29 0 0 0 0 0 0 0 0 0 0 2.492337835 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1.629060558 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.740209555 0 3.06901128 2.825879674 2.216706682 2.94040345 0 0 0 0 0 0 C24 Ceramide m+30 0 0.10256038 0 0 0 0 0 0 3.038823451 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.448943312 0 0 0 0 0 0 0 0 0 C24 Ceramide m+31 0 0 0 0 0 0 0 0 1.842408253 0 0 3.316440008 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.226573287 4.174265365 3.195716565 4.126649889 4.718433436 5.182976253 0 0 0 0 0 0 C24 Ceramide m+32 0 0 0 0 0 0.136129968 0 0 3.081923871 0 0 4.561806349 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.696077598 5.497214356 5.427409431 5.701025989 6.456193594 6.81019131 0 0 0 0 0 0 C24 Ceramide m+33 0 0 0.057524423 0 0 0 0 0 1.639746134 0 0 3.162259872 0 0 0 0 0 0 0 0 0 0 0 0 4.675340829 5.07887904 4.941530108 4.045776451 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.749159701 3.422876009 3.241752528 3.716317953 3.422618896 4.574432008 0 0 0 0 0 0 C24 Ceramide m+34 0 0 0.093423896 0 0 0 0 0 3.131513656 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.490167951 0 6.705915716 5.61003938 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.36435498 5.635871398 5.262716685 6.077401729 5.59552593 7.187681105 0 0 0 0 0 0 C24 Ceramide m+35 0 0 0 0 0 0 0 0 1.854552793 0 0 2.772158071 0 0.269739269 0 0 0 0 0 0 0 0 0 0 2.722662373 4.115181924 3.320900233 3.145706978 0 5.205712358 0 0 0 0 0 0 0 0 0 0 0 0 2.80920139 2.481790915 2.685670596 3.382415587 2.910659931 4.000210509 0 0 0 0 0 0 C24 Ceramide m+36 0.09810401 0 0 0 0 0 0 0 2.485798105 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.14539646 4.978024337 4.544918377 4.868430404 0 6.530848839 0 0 0 0 0 0 0 0 0 0 0 0 4.309582985 4.133988295 3.865543424 5.197747509 4.513959837 5.247059937 0 0 0 0 0 0 C24 Ceramide m+37 0 0 0 0 0 0 0 0 0.580868147 0 2.675507638 1.551189997 0 0 0 0 0 0 0 0 0 0 0 0 2.022691232 2.841102831 2.690016885 1.948965059 0 3.044474174 0 0 0 0 0 0 0 0 0 0 0 0 1.789325428 1.632730395 1.49753085 2.053045584 2.488856914 2.650297524 0 0 0 0 0 0 C24 Ceramide m+38 0 0 0 0 0 0 0 0 1.195219413 0 2.166764641 1.427497695 0 0 0 0 0 0 0 0 0 0 0 0 3.081276375 0 2.939290601 0 4.034136937 0 0 0 0 0 0 0 0 0 0 0 0 0 2.467598112 1.999612823 1.980754083 3.177338386 0 0 0 0 0 0.250740164 0 0 C24 Ceramide m+39 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.431739236 0 0.953346562 0 0 0 0 0 0 0 0 C24 Ceramide m+40 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.384778355 0 0 0 0 0 0 0 0 0 0 0 0 0 C24 Ceramide m+41 0 0.207421225 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.143229127 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 C24 Ceramide m+42 0.097485247 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.273485011 0 0 0 0 0 0 0 0 0 0 0 0 0 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Sphingosine m0 Sphingosine m+1 Sphingosine M+2 Sphingosine m+3 Sphingosine m+4 Sphingosine m+5 Sphingosine m+6 Sphingosine m+7 Sphingosine m+8 Sphingosine m+9 Sphingosine m+10 Sphingosine m+11 Sphingosine m+12 Sphingosine m+13 Sphingosine m+14 Sphingosine m+15 Sphingosine m+16 Sphingosine m+17 Sphingosine m+18 Sphinganine m0 Sphinganine m+1 Sphinganine M+2 Sphinganine m+3 Sphinganine m+4 Sphinganine m+5 Sphinganine m+6 Sphinganine m+7 Sphinganine m+8 Sphinganine m+9 Sphinganine m+10 Sphinganine m+11 Sphinganine m+12 Sphinganine m+13 Sphinganine m+14 Sphinganine m+15 Sphinganine m+16 Sphinganine m+17 Sphinganine m+18 C8-Ceramide m0 C8-Ceramide m+1 C8-Ceramide M+2 C8-Ceramide m+3 C8-Ceramide m+4 C8-Ceramide m+5 C8-Ceramide m+6 C8-Ceramide m+7 C8-Ceramide m+8 C8-Ceramide m+9 C8-Ceramide m+10 C8-Ceramide m+11 C8-Ceramide m+12 C8-Ceramide m+13 C8-Ceramide m+14 C8-Ceramide m+15 C8-Ceramide m+16 C8-Ceramide m+17 C8-Ceramide m+18 C8-Ceramide m+19 C8-Ceramide m+20 C8-Ceramide m+21 C8-Ceramide m+22 C8-Ceramide m+23 C8-Ceramide m+24 C8-Ceramide m+25 C8-Ceramide m+26 C14 Ceramide m0 C14 Ceramide m+1 C14 Ceramide M+2 C14 Ceramide m+3 C14 Ceramide m+4 C14 Ceramide m+5 C14 Ceramide m+6 C14 Ceramide m+7 C14 Ceramide m+8 C14 Ceramide m+9 C14 Ceramide m+10 C14 Ceramide m+11 C14 Ceramide m+12 C14 Ceramide m+13 C14 Ceramide m+14 C14 Ceramide m+15 C14 Ceramide m+16 C14 Ceramide m+17 C14 Ceramide m+18 C14 Ceramide m+19 C14 Ceramide m+20 C14 Ceramide m+21 C14 Ceramide m+22 C14 Ceramide m+23 C14 Ceramide m+24 C14 Ceramide m+25 C14 Ceramide m+26 C14 Ceramide m+27 C14 Ceramide m+28 C14 Ceramide m+29 C14 Ceramide m+30 C14 Ceramide m+31 C14 Ceramide m+32 C16 Ceramide m0 C16 Ceramide m+1 C16 Ceramide M+2 C16 Ceramide m+3 C16 Ceramide m+4 C16 Ceramide m+5 C16 Ceramide m+6 C16 Ceramide m+7 C16 Ceramide m+8 C16 Ceramide m+9 C16 Ceramide m+10 C16 Ceramide m+11 C16 Ceramide m+12 C16 Ceramide m+13 C16 Ceramide m+14 C16 Ceramide m+15 C16 Ceramide m+16 C16 Ceramide m+17 C16 Ceramide m+18 C16 Ceramide m+19 C16 Ceramide m+20 C16 Ceramide m+21 C16 Ceramide m+22 C16 Ceramide m+23 C16 Ceramide m+24 C16 Ceramide m+25 C16 Ceramide m+26 C16 Ceramide m+27 C16 Ceramide m+28 C16 Ceramide m+29 C16 Ceramide m+30 C16 Ceramide m+31 C16 Ceramide m+32 C16 Ceramide m+33 C16 Ceramide m+34 C18_1 ceramide m0 C18_1 ceramide m+1 C18_1 ceramide M+2 C18_1 ceramide m+3 C18_1 ceramide m+4 C18_1 ceramide m+5 C18_1 ceramide m+6 C18_1 ceramide m+7 C18_1 ceramide m+8 C18_1 ceramide m+9 C18_1 ceramide m+10 C18_1 ceramide m+11 C18_1 ceramide m+12 C18_1 ceramide m+13 C18_1 ceramide m+14 C18_1 ceramide m+15 C18_1 ceramide m+16 C18_1 ceramide m+17 C18_1 ceramide m+18 C18_1 ceramide m+19 C18_1 ceramide m+20 C18_1 ceramide m+21 C18_1 ceramide m+22 C18_1 ceramide m+23 C18_1 ceramide m+24 C18_1 ceramide m+25 C18_1 ceramide m+26 C18_1 ceramide m+27 C18_1 ceramide m+28 C18_1 ceramide m+29 C18_1 ceramide m+30 C18_1 ceramide m+31 C18_1 ceramide m+32 C18_1 ceramide m+33 C18_1 ceramide m+34 C18_1 ceramide m+35 C18_1 ceramide m+36 C18 ceramide m0 C18 ceramide m+1 C18 ceramide M+2 C18 ceramide m+3 C18 ceramide m+4 C18 ceramide m+5 C18 ceramide m+6 C18 ceramide m+7 C18 ceramide m+8 C18 ceramide m+9 C18 ceramide m+10 C18 ceramide m+11 C18 ceramide m+12 C18 ceramide m+13 C18 ceramide m+14 C18 ceramide m+15 C18 ceramide m+16 C18 ceramide m+17 C18 ceramide m+18 C18 ceramide m+19 C18 ceramide m+20 C18 ceramide m+21 C18 ceramide m+22 C18 ceramide m+23 C18 ceramide m+24 C18 ceramide m+25 C18 ceramide m+26 C18 ceramide m+27 C18 ceramide m+28 C18 ceramide m+29 C18 ceramide m+30 C18 ceramide m+31 C18 ceramide m+32 C18 ceramide m+33 C18 ceramide m+34 C18 ceramide m+35 C18 ceramide m+36 C20 ceramide m0 C20 ceramide m+1 C20 ceramide M+2 C20 ceramide m+3 C20 ceramide m+4 C20 ceramide m+5 C20 ceramide m+6 C20 ceramide m+7 C20 ceramide m+8 C20 ceramide m+9 C20 ceramide m+10 C20 ceramide m+11 C20 ceramide m+12 C20 ceramide m+13 C20 ceramide m+14 C20 ceramide m+15 C20 ceramide m+16 C20 ceramide m+17 C20 ceramide m+18 C20 ceramide m+19 C20 ceramide m+20 C20 ceramide m+21 C20 ceramide m+22 C20 ceramide m+23 C20 ceramide m+24 C20 ceramide m+25 C20 ceramide m+26 C20 ceramide m+27 C20 ceramide m+28 C20 ceramide m+29 C20 ceramide m+30 C20 ceramide m+31 C20 ceramide m+32 C20 ceramide m+33 C20 ceramide m+34 C20 ceramide m+35 C20 ceramide m+36 C20 ceramide m+37 C20 ceramide m+38 C22 Ceramide m0 C22 Ceramide m+1 C22 Ceramide M+2 C22 Ceramide m+3 C22 Ceramide m+4 C22 Ceramide m+5 C22 Ceramide m+6 C22 Ceramide m+7 C22 Ceramide m+8 C22 Ceramide m+9 C22 Ceramide m+10 C22 Ceramide m+11 C22 Ceramide m+12 C22 Ceramide m+13 C22 Ceramide m+14 C22 Ceramide m+15 C22 Ceramide m+16 C22 Ceramide m+17 C22 Ceramide m+18 C22 Ceramide m+19 C22 Ceramide m+20 C22 Ceramide m+21 C22 Ceramide m+22 C22 Ceramide m+23 C22 Ceramide m+24 C22 Ceramide m+25 C22 Ceramide m+26 C22 Ceramide m+27 C22 Ceramide m+28 C22 Ceramide m+29 C22 Ceramide m+30 C22 Ceramide m+31 C22 Ceramide m+32 C22 Ceramide m+33 C22 Ceramide m+34 C22 Ceramide m+35 C22 Ceramide m+36 C22 Ceramide m+37 C22 Ceramide m+38 C22 Ceramide m+39 C22 Ceramide m+40 C24_1 Ceramide m0 C24_1 Ceramide m+1 C24_1 Ceramide M+2 C24_1 Ceramide m+3 C24_1 Ceramide m+4 C24_1 Ceramide m+5 C24_1 Ceramide m+6 C24_1 Ceramide m+7 C24_1 Ceramide m+8 C24_1 Ceramide m+9 C24_1 Ceramide m+10 C24_1 Ceramide m+11 C24_1 Ceramide m+12 C24_1 Ceramide m+13 C24_1 Ceramide m+14 C24_1 Ceramide m+15 C24_1 Ceramide m+16 C24_1 Ceramide m+17 C24_1 Ceramide m+18 C24_1 Ceramide m+19 C24_1 Ceramide m+20 C24_1 Ceramide m+21 C24_1 Ceramide m+22 C24_1 Ceramide m+23 C24_1 Ceramide m+24 C24_1 Ceramide m+25 C24_1 Ceramide m+26 C24_1 Ceramide m+27 C24_1 Ceramide m+28 C24_1 Ceramide m+29 C24_1 Ceramide m+30 C24_1 Ceramide m+31 C24_1 Ceramide m+32 C24_1 Ceramide m+33 C24_1 Ceramide m+34 C24_1 Ceramide m+35 C24_1 Ceramide m+36 C24_1 Ceramide m+37 C24_1 Ceramide m+38 C24_1 Ceramide m+39 C24_1 Ceramide m+40 C24_1 Ceramide m+41 C24_1 Ceramide m+42 C24 Ceramide m0 C24 Ceramide m+1 C24 Ceramide M+2 C24 Ceramide m+3 C24 Ceramide m+4 C24 Ceramide m+5 C24 Ceramide m+6 C24 Ceramide m+7 C24 Ceramide m+8 C24 Ceramide m+9 C24 Ceramide m+10 C24 Ceramide m+11 C24 Ceramide m+12 C24 Ceramide m+13 C24 Ceramide m+14 C24 Ceramide m+15 C24 Ceramide m+16 C24 Ceramide m+17 C24 Ceramide m+18 C24 Ceramide m+19 C24 Ceramide m+20 C24 Ceramide m+21 C24 Ceramide m+22 C24 Ceramide m+23 C24 Ceramide m+24 C24 Ceramide m+25 C24 Ceramide m+26 C24 Ceramide m+27 C24 Ceramide m+28 C24 Ceramide m+29 C24 Ceramide m+30 C24 Ceramide m+31 C24 Ceramide m+32 C24 Ceramide m+33 C24 Ceramide m+34 C24 Ceramide m+35 C24 Ceramide m+36 C24 Ceramide m+37 C24 Ceramide m+38 C24 Ceramide m+39 C24 Ceramide m+40 C24 Ceramide m+41 C24 Ceramide m+42 METABOLITES_END #END