#METABOLOMICS WORKBENCH michaelsa93_20171211_145435_mwtab.txt DATATRACK_ID:1281 STUDY_ID:ST000911 ANALYSIS_ID:AN001481 PROJECT_ID:PR000631
VERSION             	1
CREATED_ON             	January 4, 2018, 11:14 am
#PROJECT
PR:PROJECT_TITLE                 	Insights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue
PR:PROJECT_TITLE                 	syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid
PR:PROJECT_SUMMARY               	Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling
PR:PROJECT_SUMMARY               	illness characterized by six months or more of unexplained profound fatigue with
PR:PROJECT_SUMMARY               	post-exertional malaise, sleep abnormalities, cognitive dysfunction and
PR:PROJECT_SUMMARY               	autonomic disturbances. Focusing on the pathogenesis of central nervous system
PR:PROJECT_SUMMARY               	abnormalities in ME/CFS, we pursued metabolomics analysis of cerebrospinal fluid
PR:PROJECT_SUMMARY               	(CSF) in 32 ME/CFS cases, 40 subjects with multiple sclerosis (MS), another
PR:PROJECT_SUMMARY               	fatiguing illness, and 19 healthy subjects with no neurological disease (ND).
PR:PROJECT_SUMMARY               	MS/ND subjects were frequency matched for age and sex to ME/CFS subjects. Three
PR:PROJECT_SUMMARY               	untargeted metabolomic assays for primary metabolites, biogenic amines and
PR:PROJECT_SUMMARY               	complex lipids were performed with gas chromatography time-of-flight (GC-TOF)
PR:PROJECT_SUMMARY               	and liquid chromatography–tandem mass spectrometry (LC-MS/MS) yielding
PR:PROJECT_SUMMARY               	profiles for 525 known metabolites. Mannose was a cardinal biomarker in ME/CFS
PR:PROJECT_SUMMARY               	subjects with reduced levels in ME/CFS compared to both MS and ND subjects.
PR:PROJECT_SUMMARY               	Levels of acetylcarnitine were reduced in ME/CFS vs. MS subjects. The predictive
PR:PROJECT_SUMMARY               	power of metabolomic analysis for diagnosis of ME/CFS vs. ND was higher
PR:PROJECT_SUMMARY               	(cross-validated AUC 0.875; 95% CI: 0.726~0.949) than with cytokine analysis
PR:PROJECT_SUMMARY               	alone (cross-validated AUC 0.865; 95% CI: 0.673~0.952) and improved with
PR:PROJECT_SUMMARY               	integration of both metabolomics and cytokine analyses (cross-validated AUC
PR:PROJECT_SUMMARY               	0.916; 95% CI: 0.791~0.969). Our findings confirm the biological basis of
PR:PROJECT_SUMMARY               	ME/CFS, and may enable new methods for diagnosis and insight into cognitive and
PR:PROJECT_SUMMARY               	autonomic disturbances in this syndrome.
PR:INSTITUTE                     	Columbia University
PR:DEPARTMENT                    	Center for Infection and Immunity, Mailman School of Public Health
PR:LAST_NAME                     	Lipkin
PR:FIRST_NAME                    	Ian
PR:ADDRESS                       	722 West 168th Street, Room 1703a, New York, NY USA 10032
PR:EMAIL                         	wil2001@columbia.edu
PR:PHONE                         	212-342-9044
#STUDY
ST:STUDY_TITLE                   	Insights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue
ST:STUDY_TITLE                   	syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid (part II)
ST:STUDY_SUMMARY                 	Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling
ST:STUDY_SUMMARY                 	illness characterized by six months or more of unexplained profound fatigue with
ST:STUDY_SUMMARY                 	post-exertional malaise, sleep abnormalities, cognitive dysfunction and
ST:STUDY_SUMMARY                 	autonomic disturbances. Focusing on the pathogenesis of central nervous system
ST:STUDY_SUMMARY                 	abnormalities in ME/CFS, we pursued metabolomics analysis of cerebrospinal fluid
ST:STUDY_SUMMARY                 	(CSF) in 32 ME/CFS cases, 40 subjects with multiple sclerosis (MS), another
ST:STUDY_SUMMARY                 	fatiguing illness, and 19 healthy subjects with no neurological disease (ND).
ST:STUDY_SUMMARY                 	MS/ND subjects were frequency matched for age and sex to ME/CFS subjects. Three
ST:STUDY_SUMMARY                 	untargeted metabolomic assays for primary metabolites, biogenic amines and
ST:STUDY_SUMMARY                 	complex lipids were performed with gas chromatography time-of-flight (GC-TOF)
ST:STUDY_SUMMARY                 	and liquid chromatography–tandem mass spectrometry (LC-MS/MS) yielding
ST:STUDY_SUMMARY                 	profiles for 525 known metabolites. Mannose was a cardinal biomarker in ME/CFS
ST:STUDY_SUMMARY                 	subjects with reduced levels in ME/CFS compared to both MS and ND subjects.
ST:STUDY_SUMMARY                 	Levels of acetylcarnitine were reduced in ME/CFS vs. MS subjects. The predictive
ST:STUDY_SUMMARY                 	power of metabolomic analysis for diagnosis of ME/CFS vs. ND was higher
ST:STUDY_SUMMARY                 	(cross-validated AUC 0.875; 95% CI: 0.726~0.949) than with cytokine analysis
ST:STUDY_SUMMARY                 	alone (cross-validated AUC 0.865; 95% CI: 0.673~0.952) and improved with
ST:STUDY_SUMMARY                 	integration of both metabolomics and cytokine analyses (cross-validated AUC
ST:STUDY_SUMMARY                 	0.916; 95% CI: 0.791~0.969). Our findings confirm the biological basis of
ST:STUDY_SUMMARY                 	ME/CFS, and may enable new methods for diagnosis and insight into cognitive and
ST:STUDY_SUMMARY                 	autonomic disturbances in this syndrome.
ST:INSTITUTE                     	University of California, Davis
ST:DEPARTMENT                    	Genome and Biomedical Sciences Facility
ST:LABORATORY                    	WCMC Metabolomics Core
ST:LAST_NAME                     	Fiehn
ST:FIRST_NAME                    	Oliver
ST:ADDRESS                       	1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis,
ST:ADDRESS                       	CA 95616
ST:EMAIL                         	ofiehn@ucdavis.edu
ST:PHONE                         	(530) 754-8258
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	DPCSF0106	Lipkin024_posCSH_DPCSF0106_108.d	Diagnosis:ND | Sex:FEMALE	Age=49
SUBJECT_SAMPLE_FACTORS           	DPCSF0146	Lipkin056_posCSH_DPCSF0146_105.d	Diagnosis:ND | Sex:FEMALE	Age=58
SUBJECT_SAMPLE_FACTORS           	DPCSF0426	Lipkin001_posCSH_DPCSF0426_003.d	Diagnosis:MECFS | Sex:MALE	Age=23
SUBJECT_SAMPLE_FACTORS           	DPCSF0614	Lipkin089_posCSH_DPCSF0614_035_2.d	Diagnosis:MS | Sex:FEMALE	Age=51
SUBJECT_SAMPLE_FACTORS           	DPCSF0747	Lipkin042_posCSH_DPCSF0747_027.d	Diagnosis:MS | Sex:FEMALE	Age=42
SUBJECT_SAMPLE_FACTORS           	DPCSF0828	Lipkin034_posCSH_DPCSF0828_031.d	Diagnosis:ND | Sex:FEMALE	Age=36
SUBJECT_SAMPLE_FACTORS           	DPCSF0868	Lipkin104_posCSH_DPCSF0868_089_3.d	Diagnosis:MS | Sex:FEMALE	Age=50
SUBJECT_SAMPLE_FACTORS           	DPCSF0909	Lipkin102_posCSH_DPCSF0909_078.d	Diagnosis:MS | Sex:MALE	Age=54
SUBJECT_SAMPLE_FACTORS           	DPCSF1041	Lipkin027_posCSH_DPCSF1041_058.d	Diagnosis:MS | Sex:FEMALE	Age=47
SUBJECT_SAMPLE_FACTORS           	DPCSF1174	Lipkin118_posCSH_DPCSF1174_023.d	Diagnosis:MS | Sex:MALE	Age=34
SUBJECT_SAMPLE_FACTORS           	DPCSF1215	Lipkin055_posCSH_DPCSF1215_019.d	Diagnosis:ND | Sex:MALE	Age=60
SUBJECT_SAMPLE_FACTORS           	DPCSF1281	Lipkin084_posCSH_DPCSF1281_053.d	Diagnosis:ND | Sex:FEMALE	Age=57
SUBJECT_SAMPLE_FACTORS           	DPCSF1495	Lipkin074_posCSH_DPCSF1495_036.d	Diagnosis:MECFS | Sex:MALE	Age=53
SUBJECT_SAMPLE_FACTORS           	DPCSF1576	Lipkin071_posCSH_DPCSF1576_044.d	Diagnosis:MECFS | Sex:MALE	Age=62
SUBJECT_SAMPLE_FACTORS           	DPCSF1815	Lipkin014_posCSH_DPCSF1815_122.d	Diagnosis:MS | Sex:FEMALE	Age=51
SUBJECT_SAMPLE_FACTORS           	DPCSF1870	Lipkin109_posCSH_DPCSF1870_082.d	Diagnosis:MECFS | Sex:FEMALE	Age=60
SUBJECT_SAMPLE_FACTORS           	DPCSF1896	Lipkin046_posCSH_DPCSF1896_029.d	Diagnosis:MS | Sex:FEMALE	Age=43
SUBJECT_SAMPLE_FACTORS           	DPCSF2029	Lipkin020_posCSH_DPCSF2029_041.d	Diagnosis:MS | Sex:MALE	Age=54
SUBJECT_SAMPLE_FACTORS           	DPCSF2110	Lipkin092_posCSH_DPCSF2110_119.d	Diagnosis:ND | Sex:MALE	Age=47
SUBJECT_SAMPLE_FACTORS           	DPCSF2216	Lipkin003_posCSH_DPCSF2216_007.d	Diagnosis:MECFS | Sex:FEMALE	Age=61
SUBJECT_SAMPLE_FACTORS           	DPCSF2603	Lipkin066_posCSH_DPCSF2603_048.d	Diagnosis:MECFS | Sex:MALE	Age=18
SUBJECT_SAMPLE_FACTORS           	DPCSF2710	Lipkin108_posCSH_DPCSF2710_064.d	Diagnosis:ND | Sex:FEMALE	Age=51
SUBJECT_SAMPLE_FACTORS           	DPCSF2750	Lipkin038_posCSH_DPCSF2750_120.d	Diagnosis:ND | Sex:MALE	Age=46
SUBJECT_SAMPLE_FACTORS           	DPCSF2924	Lipkin059_posCSH_DPCSF2924_118.d	Diagnosis:ND | Sex:MALE	Age=60
SUBJECT_SAMPLE_FACTORS           	DPCSF2938	Lipkin110_posCSH_DPCSF2938_066.d	Diagnosis:MECFS | Sex:MALE	Age=53
SUBJECT_SAMPLE_FACTORS           	DPCSF3137	Lipkin063_posCSH_DPCSF3137_060.d	Diagnosis:MS | Sex:FEMALE	Age=46
SUBJECT_SAMPLE_FACTORS           	DPCSF3152	Lipkin120_posCSH_DPCSF3152_084.d	Diagnosis:MECFS | Sex:FEMALE	Age=41
SUBJECT_SAMPLE_FACTORS           	DPCSF3285	Lipkin037_posCSH_DPCSF3285_072.d	Diagnosis:MECFS | Sex:MALE	Age=58
SUBJECT_SAMPLE_FACTORS           	DPCSF3310	Lipkin039_posCSH_DPCSF3310_047.d	Diagnosis:ND | Sex:FEMALE	Age=34
SUBJECT_SAMPLE_FACTORS           	DPCSF3605	Lipkin051_posCSH_DPCSF3605_116.d	Diagnosis:ND | Sex:MALE	Age=57
SUBJECT_SAMPLE_FACTORS           	DPCSF3671	Lipkin019_posCSH_DPCSF3671_034.d	Diagnosis:MECFS | Sex:FEMALE	Age=58
SUBJECT_SAMPLE_FACTORS           	DPCSF3686	Lipkin087_posCSH_DPCSF3686_093.d	Diagnosis:MS | Sex:FEMALE	Age=29
SUBJECT_SAMPLE_FACTORS           	DPCSF3712	Lipkin069_posCSH_DPCSF3712_009.d	Diagnosis:MECFS | Sex:FEMALE	Age=56
SUBJECT_SAMPLE_FACTORS           	DPCSF3752	Lipkin016_posCSH_DPCSF3752_069.d	Diagnosis:MECFS | Sex:FEMALE	Age=48
SUBJECT_SAMPLE_FACTORS           	DPCSF4165	Lipkin119_posCSH_DPCSF4165_101.d	Diagnosis:MS | Sex:FEMALE	Age=35
SUBJECT_SAMPLE_FACTORS           	DPCSF4353	Lipkin097_posCSH_DPCSF4353_065.d	Diagnosis:MECFS | Sex:FEMALE	Age=44
SUBJECT_SAMPLE_FACTORS           	DPCSF4592	Lipkin007_posCSH_DPCSF4592_121.d	Diagnosis:MS | Sex:FEMALE	Age=47
SUBJECT_SAMPLE_FACTORS           	DPCSF4633	Lipkin049_posCSH_DPCSF4633_104.d	Diagnosis:MS | Sex:FEMALE	Age=48
SUBJECT_SAMPLE_FACTORS           	DPCSF4927	Lipkin031_posCSH_DPCSF4927_074.d	Diagnosis:MS | Sex:MALE	Age=53
SUBJECT_SAMPLE_FACTORS           	DPCSF5274	Lipkin052_posCSH_DPCSF5274_054.d	Diagnosis:MS | Sex:FEMALE	Age=35
SUBJECT_SAMPLE_FACTORS           	DPCSF5395	Lipkin033_posCSH_DPCSF5395_077.d	Diagnosis:MS | Sex:MALE	Age=41
SUBJECT_SAMPLE_FACTORS           	DPCSF5421	Lipkin064_posCSH_DPCSF5421_088.d	Diagnosis:MECFS | Sex:FEMALE	Age=42
SUBJECT_SAMPLE_FACTORS           	DPCSF5447	Lipkin035_posCSH_DPCSF5447_011_2.d	Diagnosis:MS | Sex:MALE	Age=44
SUBJECT_SAMPLE_FACTORS           	DPCSF5502	Lipkin076_posCSH_DPCSF5502_070_2.d	Diagnosis:MECFS | Sex:FEMALE	Age=46
SUBJECT_SAMPLE_FACTORS           	DPCSF5981	Lipkin078_posCSH_DPCSF5981_073.d	Diagnosis:MECFS | Sex:FEMALE	Age=63
SUBJECT_SAMPLE_FACTORS           	DPCSF6088	Lipkin057_posCSH_DPCSF6088_055.d	Diagnosis:MS | Sex:FEMALE	Age=36
SUBJECT_SAMPLE_FACTORS           	DPCSF6128	Lipkin036_posCSH_DPCSF6128_115.d	Diagnosis:ND | Sex:FEMALE	Age=60
SUBJECT_SAMPLE_FACTORS           	DPCSF6143	Lipkin044_posCSH_DPCSF6143_067.d	Diagnosis:MECFS | Sex:FEMALE	Age=60
SUBJECT_SAMPLE_FACTORS           	DPCSF6448	Lipkin100_posCSH_DPCSF6448_016_2.d	Diagnosis:MECFS | Sex:FEMALE	Age=51
SUBJECT_SAMPLE_FACTORS           	DPCSF6529	Lipkin004_posCSH_DPCSF6529_083.d	Diagnosis:MECFS | Sex:FEMALE	Age=55
SUBJECT_SAMPLE_FACTORS           	DPCSF6555	Lipkin113_posCSH_DPCSF6555_107.d	Diagnosis:ND | Sex:FEMALE	Age=59
SUBJECT_SAMPLE_FACTORS           	DPCSF6688	Lipkin099_posCSH_DPCSF6688_062.d	Diagnosis:MS | Sex:FEMALE	Age=46
SUBJECT_SAMPLE_FACTORS           	DPCSF6728	Lipkin067_posCSH_DPCSF6728_056.d	Diagnosis:MS | Sex:MALE	Age=37
SUBJECT_SAMPLE_FACTORS           	DPCSF6765	Lipkin041_posCSH_DPCSF6765_032.d	Diagnosis:MECFS | Sex:MALE	Age=30
SUBJECT_SAMPLE_FACTORS           	DPCSF6769	Lipkin116_posCSH_DPCSF6769_051.d	Diagnosis:ND | Sex:FEMALE	Age=45
SUBJECT_SAMPLE_FACTORS           	DPCSF6890	Lipkin011_posCSH_DPCSF6890_090.d	Diagnosis:MS | Sex:FEMALE	Age=50
SUBJECT_SAMPLE_FACTORS           	DPCSF6902	Lipkin106_posCSH_DPCSF6902_103.d	Diagnosis:MS | Sex:FEMALE	Age=38
SUBJECT_SAMPLE_FACTORS           	DPCSF7023	Lipkin045_posCSH_DPCSF7023_091.d	Diagnosis:MS | Sex:MALE	Age=53
SUBJECT_SAMPLE_FACTORS           	DPCSF7115	Lipkin098_posCSH_DPCSF7115_106.d	Diagnosis:ND | Sex:FEMALE	Age=44
SUBJECT_SAMPLE_FACTORS           	DPCSF7263	Lipkin093_posCSH_DPCSF7263_094.d	Diagnosis:MECFS | Sex:FEMALE	Age=54
SUBJECT_SAMPLE_FACTORS           	DPCSF7318	Lipkin029_posCSH_DPCSF7318_087.d	Diagnosis:MS | Sex:FEMALE	Age=42
SUBJECT_SAMPLE_FACTORS           	DPCSF7329	Lipkin086_posCSH_DPCSF7329_006.d	Diagnosis:MS | Sex:MALE	Age=39
SUBJECT_SAMPLE_FACTORS           	DPCSF7410	Lipkin090_posCSH_DPCSF7410_043.d	Diagnosis:MS | Sex:FEMALE	Age=55
SUBJECT_SAMPLE_FACTORS           	DPCSF7476	Lipkin077_posCSH_DPCSF7476_001.d	Diagnosis:MECFS | Sex:MALE	Age=51
SUBJECT_SAMPLE_FACTORS           	DPCSF7598	Lipkin048_posCSH_DPCSF7598_086.d	Diagnosis:MECFS | Sex:FEMALE	Age=39
SUBJECT_SAMPLE_FACTORS           	DPCSF7638	Lipkin081_posCSH_DPCSF7638_068.d	Diagnosis:MECFS | Sex:FEMALE	Age=52
SUBJECT_SAMPLE_FACTORS           	DPCSF7664	Lipkin050_posCSH_DPCSF7664_076.d	Diagnosis:MS | Sex:MALE	Age=43
SUBJECT_SAMPLE_FACTORS           	DPCSF7756	Lipkin005_posCSH_DPCSF7756_002.d	Diagnosis:ND | Sex:FEMALE	Age=54
SUBJECT_SAMPLE_FACTORS           	DPCSF7797	Lipkin114_posCSH_DPCSF7797_045.d	Diagnosis:ND | Sex:FEMALE	Age=37
SUBJECT_SAMPLE_FACTORS           	DPCSF7863	Lipkin072_posCSH_DPCSF7863_071.d	Diagnosis:MECFS | Sex:MALE	Age=57
SUBJECT_SAMPLE_FACTORS           	DPCSF7877	Lipkin030_posCSH_DPCSF7877_079.d	Diagnosis:MS | Sex:FEMALE	Age=44
SUBJECT_SAMPLE_FACTORS           	DPCSF7944	Lipkin105_posCSH_DPCSF7944_046.d	Diagnosis:MECFS | Sex:FEMALE	Age=54
SUBJECT_SAMPLE_FACTORS           	DPCSF7970	Lipkin053_posCSH_DPCSF7970_102.d	Diagnosis:MS | Sex:FEMALE	Age=29
SUBJECT_SAMPLE_FACTORS           	DPCSF8065	Lipkin028_posCSH_DPCSF8065_085.d	Diagnosis:MECFS | Sex:FEMALE	Age=52
SUBJECT_SAMPLE_FACTORS           	DPCSF8183	Lipkin094_posCSH_DPCSF8183_080.d	Diagnosis:MS | Sex:FEMALE	Age=41
SUBJECT_SAMPLE_FACTORS           	DPCSF8371	Lipkin080_posCSH_DPCSF8371_014.d	Diagnosis:MECFS | Sex:FEMALE	Age=68
SUBJECT_SAMPLE_FACTORS           	DPCSF8397	Lipkin117_posCSH_DPCSF8397_025.d	Diagnosis:MS | Sex:FEMALE	Age=44
SUBJECT_SAMPLE_FACTORS           	DPCSF8478	Lipkin032_posCSH_DPCSF8478_008.d	Diagnosis:MS | Sex:FEMALE	Age=43
SUBJECT_SAMPLE_FACTORS           	DPCSF8692	Lipkin091_posCSH_DPCSF8692_015_2.d	Diagnosis:MS | Sex:FEMALE	Age=44
SUBJECT_SAMPLE_FACTORS           	DPCSF8732	Lipkin065_posCSH_DPCSF8732_075.d	Diagnosis:MS | Sex:MALE	Age=51
SUBJECT_SAMPLE_FACTORS           	DPCSF8824	Lipkin068_posCSH_DPCSF8824_081.d	Diagnosis:MS | Sex:FEMALE	Age=53
SUBJECT_SAMPLE_FACTORS           	DPCSF8865	Lipkin043_posCSH_DPCSF8865_117.d	Diagnosis:ND | Sex:MALE	Age=55
SUBJECT_SAMPLE_FACTORS           	DPCSF9012	Lipkin107_posCSH_DPCSF9012_005_3.d	Diagnosis:MECFS | Sex:MALE	Age=45
SUBJECT_SAMPLE_FACTORS           	DPCSF9145	Lipkin010_posCSH_DPCSF9145_018.d	Diagnosis:MECFS | Sex:FEMALE	Age=40
SUBJECT_SAMPLE_FACTORS           	DPCSF9226	Lipkin096_posCSH_DPCSF9226_039.d	Diagnosis:MECFS | Sex:FEMALE	Age=57
SUBJECT_SAMPLE_FACTORS           	DPCSF9292	Lipkin101_posCSH_DPCSF9292_037.d	Diagnosis:MS | Sex:FEMALE	Age=36
SUBJECT_SAMPLE_FACTORS           	DPCSF9332	Lipkin009_posCSH_DPCSF9332_017.d	Diagnosis:ND | Sex:FEMALE	Age=51
SUBJECT_SAMPLE_FACTORS           	DPCSF9506	Lipkin023_posCSH_DPCSF9506_013.d	Diagnosis:MS | Sex:FEMALE	Age=46
SUBJECT_SAMPLE_FACTORS           	DPCSF9627	Lipkin075_posCSH_DPCSF9627_092.d	Diagnosis:MS | Sex:FEMALE	Age=38
SUBJECT_SAMPLE_FACTORS           	DPCSF9719	Lipkin018_posCSH_DPCSF9719_033.d	Diagnosis:MS | Sex:MALE	Age=54
SUBJECT_SAMPLE_FACTORS           	DPCSF9826	Lipkin103_posCSH_DPCSF9826_2_BU.d	Diagnosis:MECFS | Sex:MALE	Age=47
#COLLECTION
CO:COLLECTION_SUMMARY            	CSF samples obtained from lumbar punctures were retrieved from bio-repositories
CO:COLLECTION_SUMMARY            	at Sierra Internal Medicine (SIM) and Wisconsin Viral Research Group (WVRG).
CO:COLLECTION_SUMMARY            	These biobank specimens were collected over time and maintained at -80°C.
CO:SAMPLE_TYPE                   	CSF
#TREATMENT
TR:TREATMENT_SUMMARY             	3 groups: 32 ME/CFS cases (11 men, 21 women) 59 comparator/control subjects (18
TR:TREATMENT_SUMMARY             	men, 41 women), including: 40 subjects with multiple sclerosis (MS) 19 subjects
TR:TREATMENT_SUMMARY             	with non-infectious/non-inflammatory conditions (ND)
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	1) Thaw each 100 μL CSF aliquot at room temperature (see Aliquoting TEDDY
SP:SAMPLEPREP_SUMMARY            	samples SOP). Once thawed (~10min) place CSF plasma samples on ice. 2) Add 225
SP:SAMPLEPREP_SUMMARY            	μL cold “MeOH with QC mix” (see SOP “QC mix for LC-MS lipid analysis”).
SP:SAMPLEPREP_SUMMARY            	Keep MeOH on ice during extraction 3) Vortex each sample for 10s, keeping the
SP:SAMPLEPREP_SUMMARY            	rest on ice during all the extraction. 4) Add 750 μL of cold MTBE with 22:1 CE,
SP:SAMPLEPREP_SUMMARY            	keep MTBE on ice during extraction 5) Vortex for 10s 6) Shake for 6min at 4°C
SP:SAMPLEPREP_SUMMARY            	in the orbital mixer. 7) Add 188 μL room temperature LC/MS grade water. 8)
SP:SAMPLEPREP_SUMMARY            	Vortex for 20 s 9) Centrifuge for 2 min @ 14,000 rcf (12300 rpm) 10) Remove
SP:SAMPLEPREP_SUMMARY            	supernatant (upper phase), splitting into two aliquots of 300 μL, keeping one
SP:SAMPLEPREP_SUMMARY            	at –20°C for backup 11) Dry samples to complete dryness in the speed vacuum
SP:SAMPLEPREP_SUMMARY            	concentration system
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Agilent 6530
CH:COLUMN_NAME                   	Waters Acquity CSH C18 (100 x 2.1mm, 1.7um)
CH:COLUMN_NAME                   	1.7um Pre-Column
CH:FLOW_GRADIENT                 	15% B to 99% B
CH:FLOW_RATE                     	0.6 mL/min
CH:COLUMN_TEMPERATURE            	65 C
CH:METHODS_FILENAME              	Data Dictionary Fiehn laboratory_CSH QTOF lipidomics_05-29-2014.pdf
CH:SOLVENT_A                     	60:40 Acetonitrile:Water +10mM Ammonium Formate +10mM Formic Acid
CH:SOLVENT_B                     	9:1 Isopropanol:Acetonitrile +10mM Ammonium Formate +10mM Formic Acid
CH:COLUMN_PRESSURE               	450-850 bar
CH:INJECTION_TEMPERATURE         	4 C
CH:INTERNAL_STANDARD             	See data dictionary
CH:RETENTION_TIME                	See data dictionary
CH:SAMPLE_INJECTION              	1.67 uL
CH:ANALYTICAL_TIME               	13 min
CH:CAPILLARY_VOLTAGE             	3500 eV
CH:OVEN_TEMPERATURE              	50°C for 1 min, then ramped at 20°C/min to 330°C, held constant for 5 min
CH:TIME_PROGRAM                  	15 min
CH:WASHING_BUFFER                	Ethyl Acetate
CH:WEAK_WASH_SOLVENT_NAME        	Isopropanol
CH:STRONG_WASH_SOLVENT_NAME      	Isopropanol
CH:TARGET_SAMPLE_TEMPERATURE     	Autosampler temp 4 C
CH:SAMPLE_LOOP_SIZE              	30 m length x 0.25 mm internal diameter
CH:RANDOMIZATION_ORDER           	Excel generated
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:MS_COMMENTS                   	-
MS:INSTRUMENT_NAME               	Agilent 6530 QTOF
MS:INSTRUMENT_TYPE               	QTOF
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:CAPILLARY_VOLTAGE             	3500 eV
MS:COLLISION_ENERGY              	25 eV
MS:COLLISION_GAS                 	Nitrogen
MS:DRY_GAS_FLOW                  	8L/min
MS:DRY_GAS_TEMP                  	325 C
MS:FRAGMENT_VOLTAGE              	120 eV
MS:FRAGMENTATION_METHOD          	Auto MS/MS
MS:ION_SOURCE_TEMPERATURE        	325 C
MS:ION_SPRAY_VOLTAGE             	1000
MS:IONIZATION                    	Pos
MS:IONIZATION_ENERGY             	70eV
MS:MASS_ACCURACY                 	Accurate
MS:REAGENT_GAS                   	Nitrogen
MS:SOURCE_TEMPERATURE            	325 C
MS:DATAFORMAT                    	.d
MS:DESOLVATION_GAS_FLOW          	11 L/min
MS:DESOLVATION_TEMPERATURE       	350 C
MS:NEBULIZER                     	35 psig
MS:OCTPOLE_VOLTAGE               	750 eV
MS:RESOLUTION_SETTING            	Extended Dyamic Range
MS:SCAN_RANGE_MOVERZ             	60-1700 Da
MS:SCANNING_CYCLE                	2 Hz
MS:SCANNING_RANGE                	60-1700 Da
MS:SKIMMER_VOLTAGE               	65
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS         	Counts
MS_METABOLITE_DATA_START
Samples	Lipkin077_posCSH_DPCSF7476_001.d	Lipkin005_posCSH_DPCSF7756_002.d	Lipkin103_posCSH_DPCSF9826_2_BU.d	Lipkin001_posCSH_DPCSF0426_003.d	Lipkin107_posCSH_DPCSF9012_005_3.d	Lipkin086_posCSH_DPCSF7329_006.d	Lipkin003_posCSH_DPCSF2216_007.d	Lipkin032_posCSH_DPCSF8478_008.d	Lipkin069_posCSH_DPCSF3712_009.d	Lipkin035_posCSH_DPCSF5447_011_2.d	Lipkin023_posCSH_DPCSF9506_013.d	Lipkin080_posCSH_DPCSF8371_014.d	Lipkin091_posCSH_DPCSF8692_015_2.d	Lipkin100_posCSH_DPCSF6448_016_2.d	Lipkin009_posCSH_DPCSF9332_017.d	Lipkin010_posCSH_DPCSF9145_018.d	Lipkin055_posCSH_DPCSF1215_019.d	Lipkin118_posCSH_DPCSF1174_023.d	Lipkin117_posCSH_DPCSF8397_025.d	Lipkin042_posCSH_DPCSF0747_027.d	Lipkin046_posCSH_DPCSF1896_029.d	Lipkin034_posCSH_DPCSF0828_031.d	Lipkin041_posCSH_DPCSF6765_032.d	Lipkin018_posCSH_DPCSF9719_033.d	Lipkin019_posCSH_DPCSF3671_034.d	Lipkin089_posCSH_DPCSF0614_035_2.d	Lipkin074_posCSH_DPCSF1495_036.d	Lipkin101_posCSH_DPCSF9292_037.d	Lipkin096_posCSH_DPCSF9226_039.d	Lipkin020_posCSH_DPCSF2029_041.d	Lipkin090_posCSH_DPCSF7410_043.d	Lipkin071_posCSH_DPCSF1576_044.d	Lipkin114_posCSH_DPCSF7797_045.d	Lipkin105_posCSH_DPCSF7944_046.d	Lipkin039_posCSH_DPCSF3310_047.d	Lipkin066_posCSH_DPCSF2603_048.d	Lipkin116_posCSH_DPCSF6769_051.d	Lipkin084_posCSH_DPCSF1281_053.d	Lipkin052_posCSH_DPCSF5274_054.d	Lipkin057_posCSH_DPCSF6088_055.d	Lipkin067_posCSH_DPCSF6728_056.d	Lipkin027_posCSH_DPCSF1041_058.d	Lipkin063_posCSH_DPCSF3137_060.d	Lipkin099_posCSH_DPCSF6688_062.d	Lipkin108_posCSH_DPCSF2710_064.d	Lipkin097_posCSH_DPCSF4353_065.d	Lipkin110_posCSH_DPCSF2938_066.d	Lipkin044_posCSH_DPCSF6143_067.d	Lipkin081_posCSH_DPCSF7638_068.d	Lipkin016_posCSH_DPCSF3752_069.d	Lipkin076_posCSH_DPCSF5502_070_2.d	Lipkin072_posCSH_DPCSF7863_071.d	Lipkin037_posCSH_DPCSF3285_072.d	Lipkin078_posCSH_DPCSF5981_073.d	Lipkin031_posCSH_DPCSF4927_074.d	Lipkin065_posCSH_DPCSF8732_075.d	Lipkin050_posCSH_DPCSF7664_076.d	Lipkin033_posCSH_DPCSF5395_077.d	Lipkin102_posCSH_DPCSF0909_078.d	Lipkin030_posCSH_DPCSF7877_079.d	Lipkin094_posCSH_DPCSF8183_080.d	Lipkin068_posCSH_DPCSF8824_081.d	Lipkin109_posCSH_DPCSF1870_082.d	Lipkin004_posCSH_DPCSF6529_083.d	Lipkin120_posCSH_DPCSF3152_084.d	Lipkin028_posCSH_DPCSF8065_085.d	Lipkin048_posCSH_DPCSF7598_086.d	Lipkin029_posCSH_DPCSF7318_087.d	Lipkin064_posCSH_DPCSF5421_088.d	Lipkin104_posCSH_DPCSF0868_089_3.d	Lipkin011_posCSH_DPCSF6890_090.d	Lipkin045_posCSH_DPCSF7023_091.d	Lipkin075_posCSH_DPCSF9627_092.d	Lipkin087_posCSH_DPCSF3686_093.d	Lipkin093_posCSH_DPCSF7263_094.d	Lipkin119_posCSH_DPCSF4165_101.d	Lipkin053_posCSH_DPCSF7970_102.d	Lipkin106_posCSH_DPCSF6902_103.d	Lipkin049_posCSH_DPCSF4633_104.d	Lipkin056_posCSH_DPCSF0146_105.d	Lipkin098_posCSH_DPCSF7115_106.d	Lipkin113_posCSH_DPCSF6555_107.d	Lipkin024_posCSH_DPCSF0106_108.d	Lipkin036_posCSH_DPCSF6128_115.d	Lipkin051_posCSH_DPCSF3605_116.d	Lipkin043_posCSH_DPCSF8865_117.d	Lipkin059_posCSH_DPCSF2924_118.d	Lipkin092_posCSH_DPCSF2110_119.d	Lipkin038_posCSH_DPCSF2750_120.d	Lipkin007_posCSH_DPCSF4592_121.d	Lipkin014_posCSH_DPCSF1815_122.d
Factors	Diagnosis:MECFS | Sex:MALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MS | Sex:MALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:ND | Sex:MALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MS | Sex:MALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MECFS | Sex:MALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MECFS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:ND | Sex:FEMALE	Diagnosis:ND | Sex:MALE	Diagnosis:ND | Sex:MALE	Diagnosis:ND | Sex:MALE	Diagnosis:ND | Sex:MALE	Diagnosis:ND | Sex:MALE	Diagnosis:MS | Sex:FEMALE	Diagnosis:MS | Sex:FEMALE
1_CE (22:1) iSTD	1167787	1302515	1176994	1330592	1211116	1226055	1300082	1178246	1269587	1259698	1342364	1241328	1170532	1177251	1317946	1289487	1204699	1256146	1243369	1297324	1275657	1284356	1322272	1338074	1313716	1129999	1259284	1234224	1248691	797813	854597	890567	881256	867875	876565	877311	864018	854601	877542	880336	867528	888990	887351	868811	869646	883536	860877	1183179	1094178	1184105	1104006	1094358	1192998	1104657	1162585	1151395	1174387	1175508	1054630	1240852	1239500	1296297	1214804	1324851	1160142	1322838	1302739	1151288	1156739	1179890	1325718	1198924	1251292	1207416	1116333	1265006	1331790	1228630	1321448	1304021	1208408	1227467	1362294	1322432	1266889	1351648	1382318	1275122	1369715	1377094	1350958
1_Ceramide C17 iSTD	299381	285164	294910	294350	290543	296352	282689	235228	289989	284817	287020	277652	270459	272950	274970	269245	271508	273802	278429	278269	269945	272259	285933	287119	281950	285378	293601	278637	279691	256889	291079	315686	294467	313132	281031	293384	284828	304950	296025	294756	290421	297836	300679	282007	290226	299872	276668	318857	318315	309368	320129	302858	304107	309417	292449	293546	298998	298052	274443	317912	282233	302767	272413	293016	254878	295026	288602	222891	296612	278928	281404	266448	288688	266805	262294	284589	296161	278672	292955	297330	283876	275749	291423	294216	281674	287017	310319	297950	301028	302385	302488
1_Cholesterol d7 iSTD	42424	34830	38120	37247	39249	37819	34051	24722	38013	34613	34659	34133	33803	35468	33133	32524	33050	32889	35104	35766	34317	33900	35637	37299	35397	34760	38867	34171	35793	30284	39271	42047	40394	42195	36473	37377	38414	38396	37652	37159	33871	35056	40046	36962	37341	36477	37526	38617	41764	39715	43682	36016	41448	39897	39186	38821	40070	40312	35530	42872	37193	41841	37481	38390	33017	38799	37820	27364	38746	39024	37216	32660	38727	33979	36376	38548	40531	37506	37559	42131	32362	36525	38649	38835	36100	38091	42058	37015	37872	37790	42092
1_CUDA (pos) iSTD	176466	144552	183514	150150	183316	168645	154410	135280	182519	165304	162549	169971	159605	172930	155928	159695	156960	163925	166512	171818	162229	165271	164204	164550	161011	172418	187585	165745	168069	137350	160793	176044	174055	175810	148973	166943	160566	169695	159068	154301	164897	157351	169495	165216	156356	168007	158977	178336	187852	172564	184869	174883	163591	166522	171200	173696	170170	162889	159458	176998	166125	184317	176441	152725	150517	168763	171407	125285	178411	182252	158715	157060	168940	152059	156581	174733	171984	166601	166651	170688	163052	167016	165064	167150	153194	164166	176851	163789	174394	157608	176397
1_DG (12:0/12:0/0:0) iSTD	207199	164347	170909	175174	204897	188547	171207	142056	187511	182727	183605	175953	178679	192294	178491	167622	152390	162914	180151	196591	168050	176518	189279	194499	187526	195106	203433	179177	194867	123847	192001	194483	196639	204656	175423	179069	190262	196125	179246	179877	155153	165989	193496	176103	178968	173118	145485	176202	195259	185835	219946	159753	195617	196179	187851	184583	190579	186521	171367	196124	162379	191974	170759	162804	153077	170204	169498	142999	184154	169443	164451	150600	180012	165748	170151	186962	183015	179585	161526	193007	143104	168503	180034	179682	173644	178201	193416	175998	180880	170631	196034
1_DG (18:1/2:0/0:0) iSTD	771928	717166	614262	770050	824078	709707	790340	628167	757662	749596	765932	726071	679949	779483	753171	734023	597313	728602	737244	817875	727785	721543	755561	770674	788770	750006	784991	726513	805786	389865	781484	825514	796024	809896	735803	769397	783206	777320	759229	760719	701934	691769	761970	718651	720999	725637	438293	755424	750702	724015	813925	688282	769227	778328	758061	707845	757441	751941	718647	800533	594600	701726	593354	573125	560084	616812	597251	551534	671517	611061	601319	609114	628281	576698	652417	662991	632881	612582	576817	672813	466328	583987	624229	628370	599572	630648	734917	569257	601363	594906	686510
1_LPC (17:0) iSTD	510222	402779	513424	431543	526782	461862	420354	329538	466522	451094	442526	436956	440836	457406	401526	385335	417930	441667	446005	412786	427460	417858	433805	430847	411565	481105	475536	432011	440291	342344	447248	519568	479096	525122	439570	452375	456286	479782	472302	461918	435471	452992	474514	443170	449413	469314	416991	510537	495585	458785	527533	477156	470114	478030	457556	452408	450982	453557	412467	503183	441590	489093	417004	409802	372312	446084	433381	312174	494159	464635	400728	410016	434968	370615	412389	461016	445708	426520	436701	463642	427159	425199	425867	434226	397325	439562	475315	442368	439069	419075	453101
1_LPE (17:1) iSTD	55036	48833	65192	57783	73766	75109	66225	47080	77984	66676	54398	72747	80173	68343	60247	70801	57141	58688	45923	53936	47177	48715	71336	70705	65799	81733	56817	76609	75124	39092	66703	79780	60593	59978	37308	65910	43257	65746	68921	61686	60312	55143	65973	59729	61881	70618	56934	70994	61909	64388	81635	49997	40535	53675	51257	44485	55350	59205	51332	64272	56282	74562	65715	64642	55358	68027	55676	52628	73267	67814	52322	54711	66853	39383	47034	67524	62722	70138	65964	65459	62782	61321	61345	58340	50635	50847	62503	61937	66433	59593	65640
1_MG (17:0/0:0/0:0) iSTD	222126	199952	216807	207052	218581	210567	197659	180223	226103	220794	215348	215965	197210	186566	204570	203853	204201	211689	212967	203964	187507	186330	207640	226881	215616	198549	235306	217636	203927	174612	226575	247534	239267	243273	237253	245318	232812	242443	241337	226889	227955	241853	239120	225682	228560	246191	199250	258225	241216	238327	260857	239122	233747	243355	239776	242633	240434	243794	214346	259825	212870	243848	199799	204510	184120	227025	223372	174245	223796	216350	203816	197314	226576	209373	197451	223933	235338	224894	221137	244125	204356	217193	228596	221626	227359	225221	249462	223540	233025	219309	232150
1_PC (25:0) iSTD	20528	17717	18617	18683	19569	18946	17630	14225	18952	17354	17339	16976	16441	17238	16717	16509	16684	17587	16938	16632	15954	16806	17312	17430	16298	17342	18224	16879	16863	14919	17286	19169	17089	19529	16745	17858	16615	18148	17825	17304	17181	17021	17431	16379	16709	17533	16670	19283	18882	17938	19676	18269	17667	17921	17683	16905	17828	17049	16044	19303	18521	19697	16868	18087	14972	18471	17028	13091	19385	17466	17279	15947	17448	15710	16490	17861	18272	17101	18260	18624	16673	16702	17143	17678	15980	16959	18682	17205	17182	17711	18882
1_PE (17:0/17:0) iSTD	112851	122743	116346	126449	120881	116078	125798	92116	116210	113574	120667	114012	106935	101611	107772	106396	111911	110866	108726	111231	108640	112498	116137	119273	112491	113997	116775	111034	116173	85119	123787	133461	105682	129151	113192	115403	114110	107437	117162	109621	112734	115383	121732	111539	109519	122548	113797	124277	119697	116658	115910	114080	122305	120943	117169	114261	109696	116470	105091	129295	110468	119499	103048	117002	92990	118657	113766	80229	116967	106854	113154	110467	119192	106195	108652	114469	122905	115229	119238	111153	117189	128331	119115	122053	110622	132045	126213	122069	119349	126630	131680
1_SM (d35:1) iSTD	69347	62960	67666	66610	68439	65202	65493	49573	65147	62977	63984	61852	58935	60284	59736	57958	59515	59771	61084	60400	59086	59023	62697	63628	61198	68498	63914	60711	62227	52787	60794	69299	61249	68268	58803	61399	61134	67293	64660	62632	59561	63879	64553	58629	60932	62118	59446	66850	67138	64745	69944	63286	65433	64585	61983	61126	61150	61008	54260	68104	61476	67631	59333	64929	51731	65483	62400	44327	68861	60981	62033	58203	62937	53128	59229	63830	64661	61629	63230	65289	60018	60158	62910	63718	56189	61720	66986	62148	62072	65443	68256
1_Sphingosine (d17:1) iSTD	21528	18813	30814	23750	25964	23204	26063	14515	21388	21653	22409	21470	28038	24275	19651	21904	24527	24756	18011	19148	19295	20869	24096	22472	21240	27694	21450	23191	25965	15396	25424	29733	22180	24639	17532	23261	20987	24713	25298	21954	26750	22768	26828	24646	23483	28267	20127	27854	23842	26772	37523	25545	25914	23852	24896	24792	23215	23506	26187	25298	22137	25765	27753	30022	25389	26878	22216	22518	29259	29466	22924	23345	27126	24920	25276	25207	28585	27084	27228	27333	28028	28400	26380	26515	22432	24819	27346	29735	26653	28459	29119
1_TG (17:0/17:1/17:0) d5 iSTD	211011	206310	274328	207849	229707	204545	206091	162769	222291	209385	212017	204740	195951	195992	203865	179652	226958	190336	193929	199373	193654	194539	203150	212390	207828	180915	202768	199195	215995	149083	210007	181172	206729	242351	178989	177903	197627	173931	164085	163868	165739	195904	171026	185771	222490	187837	190798	206182	222994	223321	221279	227133	210528	212494	208985	231652	229229	224233	200571	239955	260875	288096	247222	247863	205060	255022	242475	189543	252163	253502	244775	223842	265376	230211	290861	269661	259106	276535	241716	256147	213360	330411	226928	247085	228203	329111	244014	243763	222166	226004	287411
CE (18:2)	2371	777	3675	1284	1121	4529	468	241	2373	3643	2457	3545	2194	3375	1082	658	1488	2620	1952	3389	475	346	4109	1444	1052	24160	1068	3208	1191	1134	1983	1462	671	3250	705	221	7049	53100	2562	2365	4721	1082	5891	604	288	3347	1820	3478	506	957	20126	1291	387	1750	5788	3332	2530	2393	1391	5501	3399	4511	1146	1138	1624	8102	2538	2266	794	2460	1600	1310	3042	820	354	1838	1674	2177	494	1529	2893	4895	1674	3095	571	577	552	7482	2087	28806	18483
Cholesterol	3687	5243	4998	4995	5237	4507	3773	3103	4307	4562	3992	5052	4252	4452	4067	3326	3575	5176	4983	3580	3729	4218	4648	4009	4255	29113	3724	4221	9594	2511	3365	3068	3149	3763	4469	2761	3672	10825	3075	4157	2893	2728	3574	2204	3735	3475	2661	3862	3636	3265	7065	3032	4540	3824	4088	4392	3648	3775	3712	5415	4429	5790	4520	4478	4022	4747	4659	2919	4013	4690	5534	3515	4173	3240	3854	5000	4489	4359	3889	4258	4207	13964	4471	5221	2891	4263	3520	5044	4136	7884	6812
DG (36:2)	760	696	678	579	603	640	501	544	882	748	741	717	908	689	899	985	501	499	716	893	564	626	649	841	879	1138	902	662	1745	19028	922	735	730	764	546	704	578	914	512	944	558	626	562	470	581	768	48373	467	734	640	787	631	827	676	515	628	673	674	590	588	583	767	791	630	444	901		626	717	599	856	567	624	410	745	633	682	683	488	628		675	728	594	771	643	756	750	545	636	689
LPC (o-16:0)																				164						5859																				177																																													
PC (30:0)	520	2743	2980	2762	2554	2185	1660	1162	1702	2021	1891	2170	2176	2416	1713	1425	1759	2557	2880	1397	1749	1972	2659	1539	1599	4701	1281	1757	2787	1298	2442	1873	1706	2567	3334	1651	2084	7151	1736	1747	1646	1514	2910	1050	2557	2488	1641	2009	1893	1829	3387	1390	2922	2224	2366	2332	2077	2048	1715	3582	2678	2069	1979	2365	1335	3127	2325	1176	1965	2573	2584	1650	2194	1085	1517	2049	2903	2032	1683	1840	2700	12051	2258	4680	327	1961	1086	2160	1449	8242	4490
PC (32:1)	450	1461	1231	1077	1088	1155	1035	898	1061	1154	1082	2045	588	1442	1028	1054	1170	1782	1517	762	1069	1061	1396	1053	1166	3841	902	1291	1409	440	1057	1324	960	1189	1644	911	1351	3953	1043	998	1155	324	1886	687	1145	1332	987	1450	909	432	1900	856	1331	1186	1280	1491	1185	1199	578	1773	1082	1290	1215	1165	798	1537	1373	778	1046	1603	1443	1240	1101	597	936	1074	1353	1126	584	1151	1374	6470	1338	2005	604	1140	669	1403	841	4193	2253
PC (34:1)	32271	80951	78379	77586	76879	63616	50750	32352	45699	66302	45012	88067	60578	52798	55796	41886	45284	80957	73768	35784	41038	47111	80078	39127	50925	159958	41125	43589	65164	41592	59638	68193	41654	58484	102264	46412	50944	236440	57346	40545	59129	44320	74098	30532	57763	81751	44544	62231	49596	45825	125221	42417	82505	60850	58924	84587	38082	57609	66244	113692	71161	69629	62407	62274	45178	80490	73080	19956	49374	74898	65325	44865	59461	23105	43653	64443	68975	43887	60336	47879	84856	183644	64448	115743	19529	59517	27774	58216	44511	159874	134759
PC (34:2)	1574	2665	4479	5342	2492	3863	3132	2279	2811	4311	3266	5040	3360	5099	2376	1316	2268	4915	3443	3694	2424	2186	5481	1899	2315	79350	2195	3638	2814	2342	2782	3143	2028	4507	2393	1467	4364	46904	2601	2738	4979	2208	5549	1309	2376	5386	1960	4857	2979	1980	31729	2670	2315	3263	5337	3358	3001	3133	3314	4642	4127	4240	2442	2718	1473	6799	3549	2447	2260	3489	3376	2505	3241	1419	3064	2806	3125	2759	1940	2383	3564	8462	2300	4291	1768	1843	1077	7834	2479	17352	10069
PC (36:1)	2124	3122	3024	3366	3137	2381	2176	1664	1973	2782	2359	3558	2886	2443	2006	1905	1816	2781	2407	1790	2252	2395	3077	1741	2177	33164	1784	1888	2749	1769	2261	2497	2085	2269	4308	1906	2143	10029	2164	1896	2207	1983	2883	1537	2324	3236	1969	2344	1953	1850	4470	1691	2912	2487	2950	3090	1467	2131	2199	4022	2858	2718	2674	2247	2293	3445	2708	1266	2076	2522	2869	1954	2433	1156	1754	2494	2800	1824	2267	2159	3196	8186	2996	4477	374	2214	978	2361	2157	6914	5011
PC (36:2)	1503	554	3078	3222	1902	2666	1850	1445	2038	2876	2440	3112	2383	2785	1524	1135	1737	2596	2272	2967	1633	1570	4038	1526	2116	139461	1479	2527	1847	1507	2148	2110	1428	3210	492	1238	2978	23196	2139	2025	3287	250	3463	466	334	3386	1481	2560	1940	1544	12792	1865	1436	2042	3362	2435	1911	2146	1820	3439	2969	3001	1687	1960	1610	4459	2445	1640	1456	2284	2387	1574	2303	1009	1624	1865	2192	1852	1553	1946	2724	1126	490	2994	1263	342	921	3715	2066	11807	7029
PC (36:3) B	435	1023	1301	1081	876	1346	634	553	1219	1248	1214	600	541	433	916	499	762	1731	1048	1211	663	671	1515	559	696	23905	690	471	674	674	759	778	676	1325	534	518	1341	14798	699	1000	917	667	1874	465	615	1275	723	1082	942	765	4238	686	789	909	1453	1196	687	1234	767	1363	1347	1319	763	809	648	1819	1225	907	785	657	530	863	983	576	997	897	1003	740	694	795	1700	2930	1106	1209	445	712	448	1754	829	5498	2938
PC (36:4) B	1022	3137	4090	3512	3203	3953	2008	2397	3256	3689	3138	4684	2969	2922	3700	1688	2614	4604	3496	2735	2319	2581	3940	2120	2769	8503	2024	2809	3020	2169	2406	3111	2258	2822	4042	2156	3641	30466	2946	1897	2875	1925	3295	1748	2506	4101	2375	3023	2649	2218	8674	2409	3749	2226	3601	4123	1947	2773	2471	5229	4035	3677	3254	3017	1647	4792	3043	1763	2238	3512	3778	2572	2763	1258	2331	3468	3610	2286	2774	2705	4544	11881	3246	4952	1485	2333	1387	7461	2729	10139	8486
PC (36:4) C	13439	29807	29107	29486	27371	23498	21137	16834	17525	25058	19049	32319	24201	22245	23648	18886	18685	31255	29361	14920	17729	20419	30053	16016	21186	50341	16468	17899	24543	21963	21708	21387	17428	20362	38535	18137	19712	71976	22441	15847	22688	17658	26994	12639	23314	30239	18275	24239	19054	17030	41175	16300	29666	21745	23745	30827	15109	21972	26803	37376	28136	25053	25729	26706	20650	27939	28596	11275	18359	28849	26773	18646	22412	11611	17940	24056	25903	18314	22653	18792	32384	61884	24920	42484	9214	22940	10532	21871	17613	53980	45049
PC (38:4) A	6390	11810	15764	12935	12567	12362	7655	7073	12578	12629	10844	14322	11042	10452	10635	6324	8925	12205	11150	11356	7831	10233	13374	7656	9826	68788	7467	9010	10859	7761	9558	11113	8386	11435	14433	7831	13977	70193	11694	8852	10683	8045	12022	7271	9249	15185	8725	9320	8780	8184	25773	8191	13347	8136	13869	15702	7440	10041	8368	20885	14307	12414	11193	10223	8757	16902	11714	4852	8615	11297	12576	8662	10661	4897	7209	11695	11503	8101	9285	9889	16734	43621	10854	17574	4995	8914	5721	19161	9504	32726	28485
PC (38:5) A	1091	1176	1568	1072	1188	1300	1149	1075	1383	1218	1115	1315	928	1061	1031	959	1028	531	1328	1584	1126	1043	1479	1101	1155	2904	955	974	1140	857	1239	1625	1115	1139	1199	1091	1082	6059	549	1076	1034	1160	1046	1209	1306	1349	1140	1143	1294	1131	2015	1219	1263	1121	1203	1255	1152	938	1063	1635	1334	1485	1102	1064	755	1449	1122	781	1256	1155	1214	1227	1183	801	998	1147	1397	1366	1123	1305	786	2788	1164	1437	984	943	799	1655	1190	2852	1890
PC (38:6) A	617	2077	3950	3148	3264	2667	2183	1521	2491	2830	1772	4315	2385	2442	2924	2085	1925	3206	3072	1919	1794	2108	3730	1446	2504	5851	2609	1508	2148	1863	2131	3163	2007	2941	3428	1578	3148	20273	3149	1617	2888	1575	3273	1102	2368	3337	1657	4621	2194	1868	8015	1256	3181	1549	2745	5090	1469	2110	2441	4249	3941	4376	2504	3347	1231	6656	3745	1049	1938	3277	3208	2181	3053	1078	2064	2469	2532	2139	2391	2358	3537	6274	1795	4811	1262	1729	1188	5439	2052	10538	7153
PC (p-34:0) or PC (o-34:1)	1721	1951	1976	1392	1544	1473	918	733	1354	1366	1599	1502	527	982	1146	1057	1526	1296	1399	1364	1369	1238	1394	1463	1568	4223	732	1440	1215	838	445	1154	727	1648	994	705	1786	4315	297	501	1206	831	1445	443	906	261	791	1056	710	772	1228	885	1245	1243	1532	1262	803	709	841	1806	1353	1975	1116	1367	1166	1824	1226	1273	1450	1183	1088	1347	1702	743	1140	1676	1331	1412	953	1359	1875	2956	1433	1520	569	1126	616	1365	1223	2530	2000
PC 32:0;	4456	6553	6264	6503	5284	3934	4120	2634	3331	4552	3769	4864	4473	4061	4485	3769	3759	5196	5873	3032	3282	4222	5128	3518	4401	6755	2979	3430	5746	3148	4394	5030	2998	4647	8162	3613	3556	10968	3321	3507	4051	3886	5149	2227	4544	5682	3476	4549	3616	3759	7177	3115	6133	4518	5118	5390	2872	3825	3549	7755	5718	5256	5084	5623	4040	5644	5331	2081	4945	5909	5648	3830	4295	2190	3641	4632	5645	3330	4256	4009	5343	25704	5398	8751	2082	4963	2592	3565	2812	11230	9119
SM (d36:1)	3384	3011	3407	3271	2952	2545	2152	1692	1731	3036	1771	2528	2457	1709	2251	1872	2055	3085	2972	1604	1716	2001	2833	1680	1986	5583	1737	1858	2530	1846	2245	2485	1481	2195	3253	1983	2102	8279	2257	1628	2608	1402	2349	1249	2339	3137	2109	2219	1990	1952	4011	1518	3134	1884	2287	3643	1629	2139	2239	4802	3006	2530	2210	2498	3000	2779	2761	1184	2104	3011	2494	2067	2392	956	1776	2432	2911	1738	2107	2085	3179	4222	2748	4158	969	2346	1097	2520	1907	4747	5318
SM (d36:2)	2124	2398	3607	2639	3022	2674	1727	1269	1683	3012	1776	2482	2123	2280	1651	1220	1768	2716	2627	1943	1303	1289	2580	1636	2001	7473	1902	2042	2673	1589	2527	2741	1585	2573	2955	1644	2734	15749	2627	1647	2872	1553	2785	1061	2547	2833	1753	2425	1881	1225	5116	1735	2552	2387	2618	3334	1934	2080	2240	4691	3087	3381	2392	2381	2177	3390	2406	1234	1623	2690	2985	1538	2748	1107	1657	3025	2541	1970	2043	2375	2751	5402	2711	3895	257	1831	1131	2887	1564	7024	5526
SM (d42:2) A	1203	1183	1276	1285	437	1186	791	412	1086	1465	281	1750	164	864	363	398	1073	380	301	281	589	379	1209	332	855	4840	683	409	1069	384	386	1349	277	1131	393	735	1774	8410	306	1033	1529	814	1883	280	410	1073	807	1488	671	399	1997	727	418	306	1359	1183	1106	922	911	1741	1410	1199	705	255	941	2167	1122	390	385	893	1294	1094	237	571	701	1025	528	236	273	1120	1258	4083	1661	1161	485	895	625	2695	1114	4005	2101
TG (46:1)	2155	4995	1968	2737	3382	2247	2149	3236	3547	12747	5320	8878	4796	4316	8443	4403	2588	4271	4496	3669	3924	4019	2757	1869	8119	5311	5182	4820	27005	1227	2325	2198	14805	4126	1771	3351	1459	1009	2027	2634	950	1798	1082	805	1941	1316	1125	1544	1154	1450	1935	1275	1400	1687	2019	1971	816	1873	1538	2079	1868	3600	2065	1969	762	3832	1996	2082	1817	979	4447	2688	4363	932	2389	1165	2601	943	1108	1131	1472	2142	1130	3109	1641	1955	1571	1965	1122	3909	2501
TG (48:1)	3538	4242	2793	2444	5075	2317	1651	2081	5451	8320	4070	6525	6706	4201	11539	2686	3650	3214	4176	5502	2524	3299	3782	1976	4530	8098	4178	3715	24750	2678	3305	2880	17218	6582	2949	2230	2366	3394	3954	3729	2140	1186	1085	1877	2426	1493	2285	1730	3182	1254	4200	2831	2115	2768	2736	3080	1743	2479	2014	2925	2684	4721	2918	1591	1948	6077	2745	2685	2121	1334	3990	3305	6429	2320	3366	2623	2450	1352	2065	2454	1762	4372	2160	4281	2540	3132	1743	3191	1460	4111	3870
TG (48:2)	2676	4829	1712	2464	3409	2392	2102	3052	3464	12387	4581	8315	4927	4173	6751	4611	2371	3819	3896	3460	3675	3558	2474	2433	7582	4889	4757	3994	33894	1943	2071	1907	13293	3684	2147	3161	1310	1950	2420	2292	1374	1628	1512	1626	1590	1700	3255	1561	1833	1156	2191	1785	1797	1758	1705	1980	1224	1599	1680	1903	1723	3085	2190	1967	1356	3377	1960	1829	1749	1554	6416	2467	4089	1496	2451	1749	2640	1628	1290	1116	1229	2623	1156	2504	1592	2190	1883	1952	1749	3666	2111
TG (49:1)	2125	4875	1492	1966	3280	2292	1829	2841	3475	10889	5312	8419	4404	3889	8573	4303	1553	3751	4280	3559	3379	3701	2478	1951	7532	6503	5156	4640	24898	916	1876	1939	11328	3458	794	2916	1517	874	1929	1668	1545	864	1179	1381	1229	1174	881	1493	1322	982	1116	1814	1402	746	650	1995	1125	1545	774	1674	1343	3019	1531	1246	1323	3438	1880	891	1580	786	7168	1895	4011	955	2329	1165	2690	1064	1425	482	1225	2099	1412	1993	1292	1744	1929	1102	1332	4052	1626
TG (49:2)	1073	2554	960	1095	2050	1092	957	503	1635	1009	3029	921	2328	334	964	2345	1160	1992	2550	1516	444	998	1204	1352	1462	2778	2648	802	16678	911	1033	926	2673	1916	1044	1505	601	841	1266	1249	641	687	548	559	724	591	673	718	1044	544	730	1047	553	911	607	795	681	778	602	1059	815	1303	1129	1044	502	1821	891	853	616	534	3586	1289	722	583	1109	784	1006	685	510	741	480	1017	530	1163	774	1060	933	816	715	1908	1184
TG (50:2)	1545	7290	2031	2026	2713	2234	3498	2418	2812	6901	6240	5124	3743	3296	11109	5702	2229	3190	2918	3164	2132	2391	2157	3454	4335	5468	3607	2996	23816	2118	997	2911	5661	6803	1587	4136	706	5924	2196	2528	732	1250	1888	1576	888	2558	1346	3004	2105	1877	10279	2133	845	1862	3022	2255	1975	1594	2827	2863	856	4958	2011	2370	2093	2609	1558	2431	2505	799	11932	3574	6407	717	2166	2794	4816	1429	1284	2519	2273	7232	2343	1677	1465	1570	2994	5018	804	5826	2200
TG (51:2)	1044	1775	730	861	1190	1043	931	1245	1457	4128	1906	3425	1907	1645	3389	1759	829	1638	1506	1451	1183	1302	816	1092	2855	2589	1894	1702	13030	936	702	854	3991	1442	720	1196	579	874	946	918	633	560	511	489	645	477	497	671	629	361	936	639	574	772	592	781	516	591	701	689	582	1072	795	899	537	1409	814	688	545	447	3498	933	1613	446	809	594	1024	516	583	645	309	787	496	931	710	977	587	733	577	1380	718
TG (52:1)	1419	2527	1112	1413	1659	1332	1043	1303	1747	2321	1674	3205	1699	1592	3157	1558	1151	1437	1540	1620	1349	1439	278	981	1934	3749	1969	1552	6555	366	1372	1109	1920	2964	945	353	1240	447	409	1535	678	772	1018	825	306	400	1185	780	993	803	1823	899	815	988	1058	1074	746	719	912	366	1186	1772	1148	1031	867	1417	945	916	957	965	2751	446	1747	843	1512	1111	351	1106	330	1056	924	1429	879	204	786	1105	990	1374	1116	1197	1228
TG (52:2)	7356	11115	6924	6291	11385	9201	8605	8715	12308	21396	10148	24288	13558	11950	22395	9453	6735	13467	9974	15613	8853	8669	6280	7543	13049	34597	11450	10535	38797	7089	7898	5357	10064	21653	5114	6953	5525	22536	7000	9244	5359	4365	5297	3923	4146	7760	6034	6034	6886	4241	29234	5564	4698	5552	6220	6623	5027	5893	6040	5608	6908	9661	6599	6706	4961	10437	5791	4741	4789	6065	9914	6473	10910	4467	6245	6452	9877	4330	4676	5129	5231	20058	5133	6920	4994	5688	4792	16025	4781	8602	7100
TG (52:3)	4344	8524	4471	3932	6818	5256	5789	5349	7308	13591	6099	14557	7980	7775	12444	5758	4684	8992	6027	10366	6253	4933	4134	4391	7794	23892	6580	6765	35989	5247	4676	3771	6656	10324	2740	4828	2965	18688	4502	6140	4573	3191	3953	3403	3817	6431	3922	4335	6135	3425	29855	3309	2786	4602	5116	5000	4334	4213	4464	3596	4238	6201	4674	4109	3347	6560	3903	3513	3575	3552	10549	4760	7931	2785	4759	4235	7502	4426	2378	3319	2599	11932	3348	4390	4107	3942	2714	9276	3451	5869	5455
TG (52:4)	2442	4141	2319	1784	4129	1572	2470	3269	2281	6061	2849	6537	3604	4490	6680	3164	2457	2979	2571	4289	3011	2792	2460	1802	3583	7165	3726	2876	18204	3180	2214	2624	3498	7564	1862	2126	1739	3033	2158	3120	2771	1768	1462	1732	2165	2700	1822	2340	4775	2184	11724	2762	1558	3914	2364	3190	2754	2518	2506	2502	1826	3198	2682	1618	1925	4359	2078	2082	2017	1810	4081	2035	5015	2109	1493	2440	2337	1925	1673	1927	1417	5159	1828	1960	2290	1626	1890	2704	1596	2173	2817
TG (54:2)	3203	7594	1753	2390	3483	2545	2225	2959	3832	5139	3436	6326	3762	3445	5658	2778	2490	3094	3078	4746	2771	2737	1918	2380	3894	10779	3713	3240	13343	2062	1947	1589	2869	6528	1780	2282	1335	3050	2156	2860	1457	1413	1539	1287	1644	1545	1514	1800	2223	1402	3720	1787	1002	1794	1675	2184	1317	909	1149	1759	1937	2779	2217	2004	1332	3881	1718	1710	1335	1508	5177	2436	3145	1436	2052	1011	2666	1889	1438	1617	1290	2984	1603	2010	1190	1912	1282	2721	1588	1562	2038
TG (54:3)	3713	7825	3481	3362	6654	4410	4036	5024	7118	9220	5346	12159	6319	6348	10450	4887	2915	5233	5119	7961	4467	4011	2935	4687	6589	15398	5587	5052	17115	3862	3253	2710	4131	13754	2305	3471	2371	5075	3370	5708	2897	2174	2790	2178	2438	3268	6781	3167	3632	2151	7356	2917	2584	3274	2900	3059	2706	2804	2799	2749	3127	5270	3433	3028	2238	10465	2768	2181	2200	2501	5432	3060	6330	2206	2657	2893	4973	2734	2233	2561	2300	6629	2819	3153	2319	2686	2159	4086	2198	3269	3305
TG (54:4)	3173	6331	2292	3056	5152	3701	4077	4670	5976	7990	4946	10761	5766	5778	9592	3992	3438	4582	4374	6953	4718	2654	2916	3562	5447	14953	4916	4494	22698	3694	2368	2969	3616	10339	2108	2472	2009	7168	2446	5437	3249	2440	2189	2424	2544	2664	2671	3431	5719	2784	9393	2376	2869	4254	3610	3551	3465	3166	3261	2582	2395	4627	3595	3077	2367	6315	2240	3009	2011	2792	5470	3196	6675	2446	3101	3089	5026	2968	2305	2529	2429	6411	2205	2505	2610	2789	2727	3364	1972	3457	2651
TG (54:5) A	1538	3092	1733	1582	2633	1973	1645	2348	3405	4083	2983	6447	2980	3481	4788	2369	1879	2252	2611	2651	2567	1759	1622	1500	3038	5154	2341	2554	9493	2015	1691	1786	2192	6318	1423	1777	1319	2861	1903	2580	1738	202	1365	1322	1261	1645	364	1808	4355	1659	3779	2143	1494	2999	2181	2166	2176	1924	1942	1620	1568	2590	2310	1579	1281	3454	1482	1695	1303	1408	2170	1839	4804	1563	1646	1720	2105	1359	381	1389	442	3274	1647	1888	1432	1653	1456	1566	1453	1645	1689
TG (56:2)	1108	2355	911	1039	1582	951	879	1242	1640	2822	1734	3128	1846	1499	2917	1502	1088	1352	1523	1373	1374	1363	810	1002	2494	2024	1794	1689	6882	667	743	726	3050	1842	681	1091	535	612	1070	910	541	470	539	439	661	490	502	583	382	556	868	690	713	926	722	778	522	713	719	749	935	1209	882	930	476	1611	844	705	678	434	2847	439	1714	569	410	789	785	712	660	745	496	834	447	1116	599	1123	575	726	764	1198	1110
TG (58:2)		4028			1163				2605	5707	3611	5551	2851	2915	5773	3515		2317	2775			2802			4905	3115	3423	3098	9174				5691	2668																												1498				3789					5273		3011																		
TG (60:2)	256	2753	151	199	1854	1229	107	1402	1663	3996	2238	4145	2225	1897	4540	2188	328	1684	1933	1779	1581	1651	1177	1313	3470	2415	2314	2252	7280	824	905	788	3892	1684	879	1105	527	360	51	919	135	666	71	99	281	38	59	43	205	581	372	315	385	57	185	300	600	159	708	434	156	1217	143	1118	606	2040	95	120	232	170	4274	1171	1774	221	1248	607	130	646	182	305	517	378	310	1334	121	1221	233	273	193	1711	1165
TG 54:0; TG(18:0/18:0/18:0);	13254	12836	13290	8828	14428	11622	5024	5825	11836	11915	7295	13928	13771	14108	8185	5879	9891	13953	14149	7220	8314	7816	7086	4845	9484	16580	13197	15107	26755	13376	14735	12697	19072	17589	9908	14068	19612	12272	11670	13886	11548	8192	10894	12685	13939	13546	13751	8529	12489	4584	13650	12290	7076	11582	6273	19940	8089	6362	12783	7363	12008	12169	13377	4796	12652	19045	8448	5214	10368	11840	7212	8230	12820	12072	13075	13291	9936	12111	9574	9412	10762	12365	4825	7051	10096	7861	10042	11512	6470	6879	6182
3.54_279.16	1922	1311	3234	1872	3018	1814	2549	1123	728	1483	3379	2763	30454	31063	1193	2807	1775	2082	5113	1680	4262	1518	2658	1401	798	1503	896	2873	2671	928	1054	1558	1311	3558	1551	1341	1155	2666	42072	2383	1493	2416	1094	310	2429	1633	2329	4314	1384	1525	2311	1001	1397	2363	1293	29470	1703	1600	3560	1856	2388	2202	243	869	1290	1297	801	2207	2636	30848	33561	2420	3573	1544	2079	30980	2201	2423	1479	31206	1582	1997	362	2076	3844	1606	1538	3156	2158	1339	1658
10.77_895.72	1094	2053	1125	348	1728	1417	1360	1629	1732	2718	1650	3358	1957	1842	2590	1439	1212	1961	1494	2472	1520	1480	1245	1238	2083	3781	1814	1746	5583	1565	1238	1153	1629	2237	1216	1243	455	2832	1141	1583	1095	1024	1326	1149	421	1736	1136	1241	1656	171	5391	1253	193	1386	1241	1375	1323	1154	1194	1023	1155	1464	1192	1193	889	1594	1036	1039	470	332	2435	1052	1826	1093	1258	1228	1975	1045	281	943	1124	2423	978	1265	1093	1200	1071	2129	1044	1156	1197
10.76_369.35	684	1410	3163	1037	2215	2287	2276	1226	1989	2396	2450	2212	1817	1991	1879	1963	2009	1725	1211	1952	1904	2135	2614	1735	955	5979	1604	2311	2129	738	2348	2021	996	3140	1078	1661	2087	17791	2158	1794	2139	1663	2365	1835	1850	2022	1764	1572	1352	2379	4222	2363	2322	2188	2759	1766	1766	2434	2586	3469	2714	2422	1849	1996	1749	3028	3093	1874	2460	2006	1771	1679	2337	1114	2112	2037	1570	2487	1446	2232	1178	2223	2060	2585	1298	1691	1106	2568	2141	5662	5292
10.48_808.74	956	1903	711	1017	1444	1148	1016	1125	1591	5095	1788	3810	1953	1469	3263	1829	411	1699	1685	1389	1388	1691	1259	1080	3142	1974	2190	1776	10467	840	745	921	5923	1678	1068	1309	611	741	1028	962	532	613	601	511	686	641	875	678	910	435	650	757	569	829	708	890	477	793	746	889	855	1116	977	885	692	1481	950	850	511	533	2159	1235	1739	638	1070	711	1220	678	639	732	458	929	549	1204	819	1038	489	715	908	1921	1099
5.78_850.55	3094	6965	6681	6634	6377	5187	4908	4364	3754	5679	3996	6926	5978	5291	5342	4367	4492	7446	6673	3819	4176	4759	6884	3580	4644	10601	3612	4510	5594	4730	5300	4945	3868	4620	8791	4076	4338	14638	5077	4335	5434	3852	6182	3053	5564	6609	3897	5468	4039	4184	8774	3517	6549	4969	5378	7024	3604	5001	6845	8095	6254	5329	6093	5964	5145	6486	6183	3007	4507	7139	5596	4527	4877	3008	4082	5833	5636	4033	5230	4271	7005	13456	5484	8967	2105	4842	2560	5028	4356	11433	9558
9.20_913.75	116559	115776	10505	166613	37217	165915	40391	103339	151669	38120	113454	31971	11920	65710	168950	112167	131957	107906	219088	3093	62881	103218	124601	9445	1880	9413	3731	48716	4199	3975	114609	189498	3320	122088	3851	24312	16382	115595	55181	50659	41183	34264	24543	17902	41413	29178	40351	18599	118882	12265	18731	15631	9339	13013	19410	1783	5112	15781	96316	20278	10012	4489	1360	5555	13542	19969	42096	888	55980	1534	18194	133635	30891	1334	12495	20332	4815	7964	5148	27938	24183	13300	4827	14256	1557	15164	3888	3181	2296	3023	20056
5.79_783.57	7025	14339	9551	2100	12212	1694	1547	8439	8945	11998	8696	14425	11380	10688	12012	1269	2140	14561	8399	1216	8517	10353	13872	7956	997	11827	856	935	11861	10067	2716	2197	4162	9932	4824	1776	5941	7088	973	7796	10558	8425	1816	6972	10344	4629	1876	4710	1874	1548	18979	1399	1776	10666	1153	13989	1092	10157	6235	3554	1582	11679	3300	12088	8136	1692	903	1482	8747	13968	2401	8803	11253	5289	1791	11820	11519	3000	10231	9107	14734	13542	12000	18819	4269	10786	5040	1460	785	25327	20429
5.79_761.59	15444	38313	16799	14174	35693	5376	11866	2385	22443	10202	20920	10744	30085	10600	26254	19743	6169	16378	12706	2679	19942	21889	8513	19227	25604	28444	20053	20428	9050	3854	8490	31664	8922	28009	47369	21632	23472	32118	9681	18728	6246	21320	10057	14292	10559	12140	20388	30540	6185	5247	24565	4155	8072	29034	5297	40233	18487	3967	9123	14926	11703	7529	28414	8423	20229	7296	34429	2040	23187	34373	32903	7499	6090	3545	21026	13950	7759	5541	5432	23269	39725	30434	5959	15460	1736	27866	3611	9226	4663	71077	12069
0.56_244.19_0.56_266.17	82392	32415	74057	13050	137821	27764	6024	5965	92029	38641	19324	35622	207962	90026	32903	61806	31862	44407	69110	20448	87991	29455	19723	10068	39313	144235	22293	51622	173846	25169	92187	95436	74258	104838	6729	55894	58120	59010	156348	36490	21770	7657	96667	29973	32715	17358	50995	12437	63955	126275	25733	61262	180161	24290	21387	52396	13837	16495	46646	46001	63779	40030	174722	31522	165043	16971	69210	48176	76637	87912	18944	32373	42169	11858	111041	65343	23222	72590	55565	35676	44761	80777	19787	58529	12903	47651	26206	57229	50883	137572	121791
0.57_214.18_0.57_236.16	10632	9823	14742	1827	20350	6701	3732	2100	15869	7932	5007	7633	46724	21249	7871	15507	9726	10422	15382	5993	11084	5405	5950	4824	8312	18195	6780	17115	12940	13607	14924	22758	19736	10946	2371	22656	16878	19353	12970	7911	8235	2649	13279	9305	16187	9639	15479	4916	21942	21569	7180	15848	27358	11855	10059	23040	6476	5892	20230	6345	12929	17407	21217	15702	26309	2715	18071	12149	13317	9465	9220	10687	14237	7851	15216	16019	8043	22378	20936	12674	10291	24534	7537	14218	5867	5677	12483	11986	15182	25332	11623
0.70_343.30_0.70_365.28	12322	22177	6774	11292	31090	14460	6074	11440	25030	19867	19207	17672	10181	12859	14552	14684	12410	15794	30340	9775	11233	13240	13103	8124	13802	12271	14145	11067	16350	15949	9556	10443	15375	40170	12100	11995	11155	9687	13034	15893	8870	9613	8383	7981	9718	6915	15099	10688	9739	8993	8248	14759	7138	10638	8552	7408	6432	9317	8584	12460	5735	13332	17340	14421	9898	40141	12584	7335	9458	8799	11776	11597	21502	8615	7656	13485	6732	8847	10457	7428	19171	21057	8837	13183	17311	10275	10134	7044	5153	7775	11207
0.83_371.33_0.83_393.31	6472	13216	1128	7119	8773	5753	4518	4442	14660	10180	11557	9754	4517	6007	9317	8212	6346	8105	11257	5759	6834	6550	7038	4786	8562	4528	6892	6620	8840	7513	5170	5194	8290	14100	5707	6218	6143	5017	7385	7311	5430	4958	5037	4774	4829	3518	6561	5900	5617	6079	3385	7245	4416	5742	4861	4112	4029	5111	4572	6358	3658	6067	5566	7904	4599	18336	6930	4996	4862	2170	5669	7658	9075	3715	3659	5595	3444	4413	4680	6988	6887	9690	4111	7130	8707	5704	4347	4037	3420	4782	7249
1.32_399.25_1.31_421.23	6475	2182144	3538	7107	3613	2295	255	2517	3406	1689	5372	1309	2484	2792	1022	791	2792	2632	538	593	9192	3954	1229	947	6943	3281	2754	2774	1620	7392	2560	1156	3243	10001	961	5039	1359	480	2585	3714	29275	956	1704	1230	2905	1432	973	1082	1705	3415	3131	2920	615	2634	2603	4884	1190	1679	748	1507	3165	11323	2783	1415	2703	3138	4984	401	3747	4962	3655	2735	5727	557	7806	33714	1349	2470	4545	5811509	4764	3771	5566	2771	2589	6205	3276	4071614	3758	1845	3198
3.13_244.19_3.13_266.17	67187	20792	19533	14571	55468	44722	16585	9007	30495	29517	27914	13467	48345	140133	22456	12346	25619	23490	27974	71899	131349	92279	81825	9347	12056	90628	20241	19233	54107	11525	28707	27377	19385	33646	3648	9364	23714	9845	20640	49553	10925	11872	24128	14162	14735	8936	14619	13217	15248	20111	11452	13241	50819	13297	16367	17691	19143	7602	12211	11574	17727	11215	66332	24186	26413	14446	22711	7352	32699	19335	25503	24994	15455	11298	43395	24283	13376	14476	25095	11068	21343	17695	11237	20488	8671	13612	12443	23612	19691	13265	26575
3.28_371.32_3.29_393.30	20965	188949	7210	217502	9454	17976	159254	80100	19599	40750	106349	14545	8585	9953	179521	172187	21543	11098	11898	58690	52895	75775	60091	134535	129668	4461	15593	6718	15452	123335	18032	24868	12550	14201	71937	29400	12562	19439	40518	36974	18796	75440	31549	8840	12980	14455	10857	56475	11172	141606	6353	14275	74509	13750	88078	17794	51618	83540	13995	93238	6624	15756	11794	209013	3639	94010	49349	91349	26748	2388	162167	33338	20902	15671	7536	9903	38948	11125	34214	33731	6539	5326	107301	73254	33202	58829	22541	8452	68844	126024	146596
3.84_338.34_3.84_360.33	690366	155911	113049	43182	269556	858125	149816	175935	358258	93894	468524	82882	133663	969916	113754	177645	287528	162774	180259	167273	384942	409265	367742	50947	45450	356861	69235	80730	135817	201446	404282	1720433	252232	411727	51770	59545	460444	62545	209823	457239	148903	256096	598889	174118	360161	114659	117121	262815	1151376	74522	265138	90530	2461250	386204	136329	593102	1930166	136432	268396	115859	97806	117492	306853	512642	177456	130585	82019	81043	249732	133380	456756	286473	127193	36863	525246	123204	149576	60789	317516	103150	565112	236668	64222	46160	124591	62608	57863	62032	103346	31193	127156
3.96_419.32_3.96_441.30	13281	33392	90131	12272	72314	40897	8320	12819	28644	27455	8707	21609	34624	67154	24343	54963	63421	51328	63497	11102	47176	14531	6601	11969	51825	86233	22455	56146	62255	16736	43416	70624	48467	74090	4028	61123	55554	35986	34054	75275	21047	7753	61478	18621	60234	30042	44746	7796	38480	70584	45706	51404	62136	39070	20811	57855	8792	14363	69175	6636	81243	35521	37280	15675	42884	17841	70904	13422	34039	43040	17735	62600	29181	12409	46685	204345	23593	40154	41808	54114	55196	65375	61561	15692	21151	13206	34032	54578	82896	102773	29117
0.55_207.16_0.56_224.19	34670	55928	88368	71760	256925	66938	45766	470027	59426	204683	61279	51800	77510	317166	58979	235702	63695	71715	70349	46644	540254	601722	46161	63458	57719	56874	54345	59291	55097	42663	50784	52894	165440	167123	58994	116470	193721	60875	8468	60068	53945	171657	33507	77832	235423	195843	66202	46709	65583	323754	90061	64749	149739	66939	57544	54279	179442	55005	189392	37859	83982	62390	410308	119462	52105	51152	162776	108609	63068	42154	62373	64870	75315	81468	68593	132231	66143	159513	43343	63075	257470	57028	68078	64737	50855	33913	65226	58140	55468	159181	217321
0.83_332.28_0.83_337.24	12262	10852	6590	3537	16717	79599	3472	1399	5595	2747	1518	3770	19441	17760	2273	76146	25904	4763	28973	21854	6531	3236	12241	12027	4228	9074	1554	5609	5507	2504	70610	96575	8173	5170	851	66374	4675	4085	1645	3492	24699	1778	4626	47372	7089	28257	2805	1962	6314	6434	5831	9427	6706	4825	3654	119352	12031	624	28487	43353	7035	83250	6978	1027	3623	4099	11997	2275	4876	59679	2707	25764	29751	4435	12176	14824	2195	157453	352939	29563	5445	46345	70015	4055	1264	17534	14984	5507	3611	8678	34836
3.06_518.37_3.06_523.33	41428	24412	80549	24094	29918	22356	21971	17293	23610	20067	21154	19779	19149	27006	21248	18556	48899	17126	19229	17665	18424	15544	14251	15838	20191	20269	20646	17119	20804	8529	18132	13934	15752	18533	10957	9540	11751	10846	10512	9494	9851	10621	9347	9188	10006	8856	7729	9705	13890	8172	10562	8584	9308	13038	13322	8680	7996	9304	8932	9628	74074	109594	77067	32503	36763	50110	48567	53155	79337	65823	42407	48182	36414	20931	55965	77306	28021	25047	22127	59176	29892	27958	24107	39463	13923	36453	19798	16272	13999	22295	40040
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3.01_409.31	47760	6206	13856	5543	45562	35430	2720	5925	20357	17698	1035	1454	38228	97090	9506	6096	16228	16086	21604	53667	1483	68340	61067	5552	6906	67035	2227	12846	1028	7039	17370	18359	11980	23523	1594	5121	15757	2811	11271	28123	5678	4751	4215	8549	9254	5191	9201	6681	9610	9891	6448	8322	34027	6926	9034	11558	12361	3226	7724	5222	11739	5647	46116	8244	19668	6677	12301	4254	2242	14037	11600	13737	1920	6552	32721	14802	7036	9354	13951	5495	15142	8860	4461	1394	3074	4827	5956	14476	10547	5356	12607
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3.12_459.42	7455	2867	2403	1789	6106	5572	2305	1234	3823	3336	3793	1804	5852	14688	3170	1699	3424	3075	3325	8329	14133	10165	8790	1273	1842	9608	2046	2464	6276	1416	3559	3511	2234	3725	535	1479	2993	1302	2092	5702	1351	1245	3002	1751	1629	159	2201	1685	1644	2700	1478	1728	6286	1742	2199	2116	2191	1194	1622	1469	1967	1250	7667	3166	3349	1934	2671	484	4469	2362	3660	3295	1880	1285	5209	2753	1807	1507	3293	1460	2949	2088	1532	2541	481	1944	1666	2900	2665	1262	3203
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3.13_221.18	20996	5915	7135	4280	17556	15530	5005	3446	10072	9630	9323	4859	15370	34813	7218	4151	8484	8872	10184	21140	33479	25409	23365	3845	5191	25875	6686	7135	17389	4333	10227	9368	7004	10641	1250	3551	8341	3710	7680	15525	4448	4193	8615	5101	5513	3841	5098	5024	5947	6625	4529	4986	15543	4769	5926	5785	5928	3223	4931	4053	6298	3953	19803	7397	9611	5268	8192	2625	10938	7838	9280	8750	4799	4201	13955	8691	5000	5383	8258	4304	8047	6013	3917	7302	2967	4909	4418	8005	6723	4565	8608
3.14_598.49	2283	4097	2468	7916	4740	3071	2202	3375	5109	4274	5051	9148	2548	1547	3753	1913	8601	3332	1936	2473	5093	4246	3328	4768	2575	14372	3097	2483	17359	7775	1805	1415	2496	4113	11640	1558	1643	1439	1933	2737	1592	139	7850	2614	4813	91	1307	1283	1660	1378	6685	3162	1709	238	1775	4127	1460	2950	1496	2790	2398	6460	4115	1467	2397	17777	4695	2841	8192	4862	3504	8408	3097	1452	6359	22583	229	1762	5974	8073	1368	3655	1411	2211	4926	5551	5025	10154	6615	2426	1876
3.15_554.46	2854	4720	2602	9514	4563	3290	2543	3431	5528	4417	5264	9722	2979	1889	4185	2086	8080	3729	2035	3832	5658	4954	4069	4874	2935	15132	3064	2602	18023	7746	4863	1532	2514	4322	12297	1746	1643	1806	2378	3583	1679	448	9215	2636	4990	747	1626	1382	2071	1375	6627	3680	1985	1323	1966	3740	1354	3090	1451	3209	2623	6356	4665	1989	2435	17929	5028	2906	8980	5139	3491	7651	3214	1378	5610	23904	192	1347	5615	7378	1912	3733	2004	2327	5486	6388	5081	10439	6099	2572	1961
3.17_601.44	4324	5856	2076	4391	4471	3682	2634	2336	5814	2958	4972	3280	1412	1791	3767	2811	4981	3251	2690	1699	2144	3058	2675	127	2087	2208	1892	1884	3765	3093	2967	3302	3926	16699	3443	4121	3194	2948	3494	4626	2861	2794	2775	2854	3450	2868	2935	3111	3367	2459	2298	3791	2576	3492	2793	2013	2613	2499	3707	4737	2105	3114	2379	3570	2425	3741	4520	1177	3412	2446	2635	4166	2469	1758	2049	2621	2316	2172	3293	3857	2077	4737	2621	2770	2473	2994	3566	1667	1930	2936	4493
3.17_510.44	3028	4904	2591	9048	4206	3648	2591	3503	5888	4450	5345	7758	3630	2327	4394	2473	7012	3763	2745	3063	5244	5573	4038	5016	3696	14865	3220	3140	16514	7065	1743	1695	2556	3947	11506	1776	1831	1633	2389	3422	2153	1143	10393	2546	3854	1259	1774	1399	1886	1229	5705	3724	2244	1576	1736	3447	1374	3463	2072	2868	2586	6051	4332	2070	2704	16189	4087	2480	8227	4470	3681	6986	3124	1450	5522	24242	1510	1646	5552	6588	1646	3512	2043	2746	5035	4707	5587	8788	5846	2787	2186
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3.19_466.41	3149	4385	2251	8736	3612	2669	2333	2624	4205	3454	3659	5343	2719	2000	3447	1962	4373	2865	2198	2504	3902	4028	3031	4044	2717	12491	2964	2780	13664	5117	1679	173	1898	3358	8767	1689	1526	1364	2158	3062	1330	458	9574	2279	2911	944	1628	1272	1465	1310	4477	3232	1909	95	1347	2742	1095	3075	1746	2159	2151	4530	3318	1575	2546	11833	3350	1537	5681	3302	2546	4778	2249	215	4187	18107	337	1474	4386	5713	1297	2448	1395	2024	4275	3910	4141	5585	4319	1999	1930
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3.43_336.33	8549	1799	1224	275	2742	11870	2362	3114	4852	1101	6694	1351	1776	14136	1594	2845	3812	1680	2397	2946	6031	6035	5656	1177	58	3877	1020	549	1838	2792	5306	25161	3614	3709	894	925	6383	1063	2551	4488	2486	4424	9885	2435	5511	1996	1869	3874	17491	1193	4218	1248	40695	5428	1832	9663	30020	2509	3799	1156	1018	916	2567	7151	1762	1677	399	1197	2470	1963	6815	3777	1124	688	6333	1449	1872	808	3718	1064	8998	3563	292	214	2076	898	1135	1076	2024	137	1156
3.46_725.52	4167	5411	2474	4582	3914	3378	2306	2136	4822	2751	4560	2858	1449	2004	4291	2660	4982	3079	2704	1326	1687	3255	3223	483	2234	2073	1641	1584	7484	3399	3416	3424	4634	29539	3852	4773	3511	3282	23017	5915	2506	2876	3337	3264	3172	2873	3360	3164	3743	2840	2552	3803	2362	3643	3292	1967	2425	2616	3696	4985	2159	3750	2334	2777	2360	7417	4457	1169	3155	1873	2655	4933	2878	1790	1955	2615	2140	2308	2982	4549	2100	6052	3100	2977	2035	2990	6950	1767	2426	3021	4142
3.47_703.51	5926	6823	2809	5446	5252	4380	2802	3282	7166	3883	5035	3819	1854	2588	5337	3443	6171	3721	3487	2164	2456	3922	3544	1252	2587	2725	2001	2208	8921	4314	4465	4705	5925	32688	4906	5301	4200	4195	26434	6942	3698	3818	4170	4230	4636	4107	3864	4350	4666	3828	3073	5086	3074	4398	4397	2688	2974	3168	4133	6505	2786	5037	3024	4218	3287	7866	5213	1581	3854	2929	3492	6466	3776	2577	2135	3346	2939	3328	4055	5537	2693	6778	3913	4461	2720	3941	7728	2686	2874	4553	5619
3.50_659.48	7922	10072	3317	7607	8528	6489	4553	4633	10322	5670	8030	5526	2866	3530	6906	5059	8073	5211	5226	2562	3622	5164	5249	2171	3183	3563	3194	3173	9658	5956	5558	6727	7798	37328	6619	7634	5577	4777	26942	9932	4857	4508	5218	5882	6471	5804	5601	5539	6663	5031	4491	6850	4354	6236	5406	3707	4446	4752	6407	8946	4205	6138	4637	6159	4570	11076	8275	2293	5651	3607	4748	7994	5368	3105	3598	4714	4359	4469	5817	7741	4701	9068	5127	5371	4119	5636	8748	3200	4877	3293	7588
3.50_659.99	4205	6860	3103	4538	1531	2891	2437	2585	5973	2422	4861	3235	1393	2181	3798	4127	5992	3410	3039	1373	1506	3417	2889	1398	1749	3151	1830	1493	4888	2772	3453	4606	4153	24574	2991	4007	2767	1206	16277	4647	3889	2171	3106	2799	4848	3091	3684	4043	3507	2946	2715	3120	1817	3563	3506	2551	2543	2658	3162	4869	2484	2908	2318	3092	2793	5007	4058	1322	3439	2736	2658	4799	1285	1707	1997	3218	2167	2105	3290	3710	3113	5616	3907	2796	2090	3406	4701	1724	2742	1097	5932
3.51_637.47	8898	12123	4665	8317	9290	6709	4864	5527	12046	6058	9506	6081	3424	3640	7361	6092	9656	6755	5631	3271	4268	5713	6140	2264	4389	4730	3479	4107	9168	5795	5833	6693	8296	36225	6930	8321	7072	5966	24480	11469	5335	5597	6428	6401	6805	6364	5951	6115	7134	5098	5588	7829	4807	7452	5525	4433	4899	5296	7031	9893	4387	6546	5981	6890	4926	11285	9345	2152	6449	4254	6024	9461	5562	4026	4176	5931	5030	4952	7072	8418	4579	9258	5911	6412	5021	6513	8557	3319	5494	6836	8902
3.52_615.46	9891	13197	4782	9195	10193	7625	4842	5933	13318	6778	10293	6886	2930	4116	8141	5765	10479	6535	5759	3240	4456	5955	6661	2572	4601	4728	3456	4464	9023	6430	6555	7747	8826	34881	7129	8887	7096	6120	22943	11133	5840	5805	6657	6686	8598	6420	5741	6363	7889	5810	5458	7957	5062	7088	6437	4668	5468	5529	7690	10999	4631	6859	5451	7489	5415	11529	9769	2534	7545	4442	6273	9061	5840	4267	4499	6052	5157	4828	7538	8679	5360	9711	6449	6498	5363	7551	8469	3635	5792	7404	9981
3.54_414.27	5854	2790	31679	7734	1000	5214	12797	4566	5836	1821	1434	4025	2577	1928	3773	7019	1388	2363	4564	2349	2361	3964	37597	2894	4741	4484	1821	3129	5721	24121	3127	702	1016	1716	2181	1837	1712	2765	74763	1521	3874	1247	26236	24485	1108	511	789	2091	2116	815	3603	27752	3504	4284	2330	1367	2479	1162	970	4460	506	2645	3252	5498	2158	32436	2000	2819	3963	2347	34963	2701	2896	4035	6336	1822	2266	1546	3598	36789	25906	4178	2255	646	2760	2188	2586	4465	3791	4536	37926
3.54_593.44	10224	12953	4707	8540	10452	7273	5596	5883	12695	6504	10437	6468	3266	4139	8179	5978	10037	6732	5490	3358	4117	6973	6365	2618	4854	4900	3678	4042	7988	5586	6968	7955	8098	32388	7074	8382	6808	6879	19230	11000	6728	5571	6746	6421	8326	6869	5613	7403	7655	5444	5070	7423	5673	7809	5750	5047	5597	5478	7977	9909	4797	6671	5782	7881	4950	11007	10454	2719	7362	4600	6185	9359	6079	4360	4430	5861	5034	5693	7732	8537	5487	9143	6200	6828	6109	7630	7314	3807	6526	7623	9104
3.56_571.43	8785	12175	4658	7777	9821	7238	5276	5430	12745	6106	10175	5881	3124	3959	7428	6328	10068	6613	5365	3109	3850	6528	6201	2467	4968	5122	3520	3969	7085	5156	6097	6819	8461	27795	6708	8083	6155	5728	17471	10636	5994	5920	6767	6283	7685	6781	5685	6448	7128	5090	5126	7305	5493	7217	5822	5286	4916	5555	7634	10135	4299	6250	5580	6738	4440	10482	9146	2393	6908	4721	5927	9020	5409	4498	4681	5722	5134	4884	8081	8379	5142	8456	6238	6124	5231	6656	6474	3922	6077	6643	9544
3.58_369.43	29756	52053	12548	31167	24616	35298	56208	11828	35384	12451	26680	32142	9075	13072	23339	26746	17430	22718	1416	4342	1618	35193	28846	5614	18353	5760	1462	9617	16412	7570	16817	1637	5137	24129	5432	10122	10858	16572	13935	23772	11453	11119	13462	12004	18718	11357	10033	10601	13590	12579	11831	19706	16462	1551	1630	1553	1539	9731	13702	11676	14652	81761	34204	9641	20034	14030	16997	1912	1419	12318	14793	17111	14032	5199	33681	57167	4740	6995	6960	13898	9687	9287	9225	9825	1443	30947	9659	23608	12692	9379	14945
3.64_368.43	130221	222747	52751	125639	100306	140092	208194	55838	173394	66702	126693	139700	38381	57189	110546	115948	88130	115648	77005	26573	50794	164371	134726	27737	82953	27474	25759	46920	75657	37795	81438	83433	28101	131744	27079	42476	48267	61422	74112	111859	48850	52420	47949	54447	100237	49554	48992	49973	63459	68912	60282	89894	71124	47213	55031	58367	17952	55709	60642	56976	67672	400906	159418	42777	94604	66289	80031	15688	82337	46919	69232	89876	62407	25275	139688	310532	28493	27796	58570	64449	48914	51518	55768	56891	101670	207642	50320	107060	63431	41865	73167
3.84_361.33	1821	951	7257	748	2237	30109	3609	983	985	615	1817	851	2598	5280	737	1497	13767	1257	10043	7753	1853	1426	2056	609	3412	3126	478	4757	1363	11619	1806	4451	11705	3610	3747	4144	3353	547	11162	2991	6961	1545	2232	1115	14612	5987	6235	351	37155	4705	2867	559	55668	1681	816	1609	48717	1856	1814	817	1841	443	3696	2684	1585	285	627	1012	2297	996	17455	1063	289	620	1693	1827	1190	258	2886	7654	3529	2758	499	3716	1145	1715	4067	668	1195	2101	474
3.86_992.74	9937	10018	1692	8610	4148	7850	2274	3010	10351	3450	7643	3130	1731	2920	6527	5086	7774	6659	9979	1214	3160	5017	6843	1132	1304	1857	1348	3652	1504	1297	2712	6693	228	4123	624	1595	1252	4541	1960	3466	1861	1738	1237	329	1828	1072	2167	1706	5369	1201	1143	1227	1555	1606	1441	830	1220	1868	4296	1707	1382	1729	68	151	1929	1960	3772	110	5848	1224	2179	8288	1386	89	1367	2548	1397	384	1379	1717	1651	1466	1279	1738	292	1694	1092	991	694	1112	2168
3.89_441.30	4204	2514	48915	5187	40775	24146	4809	6174	3505	15594	6890	12605	19382	43027	14346	29689	35722	8711	36194	6558	28358	8780	4806	6837	29312	49524	12366	6929	35496	7973	23485	43145	56836	19929	3302	32326	34368	18791	20750	45646	11223	4561	38942	22730	39093	19000	26646	4757	23948	39863	27363	4074	38829	22115	13644	31656	11132	8901	37683	5645	43650	20235	19081	10404	8053	2037	9135	1248	17200	7176	9193	35794	1220	7104	26586	36557	14460	22502	27704	30246	36561	38422	8002	1369	12937	6145	19887	6623	47924	57869	14825
3.89_997.69	11726	14031	2245	15131	4971	10515	5133	8011	16409	5916	11528	7146	4094	3606	13167	9279	10554	10164	14702	2670	5647	8661	11238	3277	2568	2487	3103	6198	2553	2330	4237	7169	342	4990	1097	2490	1657	10593	2802	4526	4042	3318	1806	1581	2839	2047	5029	2567	7216	2248	2511	2371	1494	2330	2194	1201	1571	3443	6585	2771	1934	2388	1684	1917	3016	3271	5317	1664	7082	2067	3294	10808	2491	1617	1512	3091	2237	1949	2025	2261	2839	2033	2338	3322	1623	3150	2019	1810	1756	1987	3515
3.97_859.61	754	3310	17283	246	11982	4671	315	814	3101	2675	561	1956	4453	10863	2062	7192	10176	8484	11116	578	6464	877	565	720	7808	15645	1979	8929	10646	1115	6052	10205	21390	13371	211	9889	8793	4151	3947	13437	1682	340	10335	4791	10125	4133	6821	414	4262	13318	6947	7790	7239	4643	1709	9072	772	188	12160	610	15716	4177	4680	770	7042	1168	12071	818	3463	5945	1089	10059	3174	905	6645	51111	2174	5426	5288	8662	8549	11564	9790	1225	1650	808	4368	9325	16480	22525	2632
3.97_457.27	1449	3328	6773	246	5812	3604	681	1441	2876	3070	376	298	3284	5286	2421	4459	5399	4658	5224	494	4417	266	191	349	528	6356	2389	5130	5669	1904	3953	5343	670	6160	608	5078	4999	294	3212	5930	2197	1277	5675	3568	5602	3225	3991	166	3397	754	4289	4746	4688	3636	2323	609	1504	1457	5731	1146	6832	3257	3399	432	3980	429	5783	507	3333	4040	1821	5434	2979	1503	4497	12642	2705	3807	4387	820	4636	5395	5145	1751	2056	1438	3348	5051	1277	7313	2793
4.00_420.32	2347	2245	6999	2353	8697	4790	1009	2352	2116	2385	1128	2681	3970	7528	2743	4184	5508	4182	4806	1746	5320	2238	1529	1691	4293	7049	2050	3716	4471	2828	3464	8352	1384	11378	785	3503	4173	4286	4162	6608	2839	1312	5353	4501	4809	2348	5480	1456	4385	5711	4071	3951	6471	3321	2400	7797	1965	1414	4860	1399	6742	2653	4477	2364	3000	2154	10014	1772	2829	1933	829	7977	3485	1835	4979	35704	3071	2796	3098	3876	5209	4712	4000	2061	1754	1628	2421	6553	6096	9611	1882
4.07_419.32	4550	1932	30708	3115	22652	1274	2098	3493	6574	2895	3437	5791	11040	20668	4786	13977	8663	10202	20603	2240	13890	5291	2862	2664	13608	28740	1745	14889	12980	4133	12660	17249	19263	22974	2643	8572	7594	11138	6177	22410	7130	2606	15288	11503	9107	9190	11679	2581	11302	19699	12441	14094	2739	1761	1687	3748	4307	4364	19697	2673	25067	8209	8881	4445	14119	5419	11313	1516	4554	12514	5545	9195	3268	3105	13396	60879	6431	11203	2806	9413	16271	21874	15171	5408	5037	2123	9547	18501	24387	24166	5167
4.68_553.39	4845	12281	12166	3743	3957	5298	4190	2992	6293	5095	10685	3312	9657	3239	5376	3020	8290	5248	3123	2905	4007	9372	5149	3600	2822	5325	4140	3670	1795	2591	5681	3704	4953	6884	3469	3837	3078	3913	6285	7248	4475	4460	4364	4220	6865	3535	4511	3560	4958	3019	3244	6212	5869	4676	5747	49064	3230	4431	11241	12243	11177	5753	3437	2708	2294	3441	6965	3540	5199	6456	9295	7702	8527	6864	9175	5908	8453	5989	3750	5451	3491	14271	3778	4699	5654	11644	3998	3083	3557	6362	7374
4.81_983.72	10682	12819	2481	13341	5644	12693	4962	8014	18119	5581	12603	6372	4187	4682	12412	9778	11751	10580	14691	2791	5963	10268	11361	3260	2666	2884	2920	6033	2838	2129	5281	11198	1182	5802	1141	2740	2272	10093	3266	5080	3889	3425	2409	1739	3169	2240	4590	2595	9003	2404	2781	2444	2147	2529	2453	1713	2084	3549	7688	2744	2451	2464	1758	1954	3113	3306	5673	1379	6997	2348	3483	11452	2692	1593	2037	3673	2463	2106	2219	2606	3625	2569	2365	2981	1797	2918	2264	2147	2052	2083	3387
5.02_703.58	4839	4534	6900	5186	2806	4955	2702	2349	3625	5691	4259	4660	4706	3825	3955	2115	3429	5212	4710	4582	2716	2947	4795	3809	3297	46913	2738	3579	8046	3142	3806	4669	2742	5068	5025	2513	6408	36419	4291	3845	4482	3293	6262	2557	3268	5540	3209	5328	3001	3157	13670	3583	5313	3616	6377	6738	4066	4510	3632	9059	6045	6500	4235	4104	3861	7455	4774	2486	3819	5251	5184	3540	4255	2155	2451	4594	4831	4309	3303	4333	5466	21025	5757	7500	1839	4360	2516	9891	3871	17970	10364
5.03_494.57	3928	9504	2060	4351	15812	4215	3784	4939	8927	6238	7621	6744	3916	3486	6569	3971	3269	4020	10595	4244	2395	4089	3455	2736	4364	5194	5220	4450	3780	4221	2664	3185	3685	7823	2291	4568	3068	2397	3217	3491	2050	1950	3444	3113	3002	2080	2135	2074	3894	2123	2826	3266	1954	2537	2489	1761	1812	2467	1916	3866	2076	6356	3013	3323	1941	4832	3055	1837	2740	3030	3082	3351	3855	2137	2670	2636	3175	2000	2529	2373	2617	5104	2339	3960	1881	3284	2738	2146	3683	3122	2839
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5.09_619.38	3655	2679	3794	2837	7836	4817	2667	4502	4950	3947	5795	4418	5812	6691	4991	4525	2728	4722	3806	4629	4148	2577	2986	2447	5390	5500	4790	3773	6314	177	2805	2748	2589	2713	2701	2822	2434	2226	2225	2282	2280	2016	1642	2220	1841	1658	143	2370	2183	1808	2001	1924	2681	4633	3545	1906	1278	1929	3183	1926	3340	4938	6422	2037	2382	3455	2218	4926	5534	8522	3969	2748	2054	2685	1395	5072	1367	1216	1833	4928	1555	1364	1387	3009	1440	3310	1916	427	1346	1945	2699
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8.25_906.26	28543	3294	3067	1732	1923	6067	1832	1429	1661	2452	1802	2085	4027	2444	2008	1755	2765	1934	2075	1245	4464	1441	2830	2717	3206	3814	1480	2041	1855	3963	2893	2478	3045	2262	1030	1929	1682	2794	1475	1612	2406	1641	2630	2415	1796	3494	1572	3174	4057	2683	3531	3278	3194	2507	2547	2084	1581	1588	2221	1957	3536	3377	4801	4142	2643	2804	2856	1847	3002	3218	2421	2633	4840	14050	5014	3356	3755	3799	3840	5739	3555	4549	3928	3715	5085	3654	3611	3769	2023	5307	3609
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8.73_980.28	22859	2765	3310	1809	2194	5448	1364	1731	1723	2533	1688	2163	3099	1945	2192	1674	2649	1679	1941	1510	3219	1406	2450	2672	3066	3550	1536	1825	1762	3781	2389	2409	3304	1808	1291	2188	1632	2536	1331	1402	2330	1590	2429	2038	1914	3014	1486	2935	3330	2356	3675	3283	3065	2383	2042	2518	1770	1692	2139	2002	3482	3368	4237	4028	2900	3091	2961	1980	3489	4238	2850	2973	4828	11506	4249	3297	4378	4250	3985	5628	4058	4737	4160	4647	5680	4119	4242	4238	2722	4609	3850
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9.20_914.75	11703	68457	2253	32018	5875	98217	25703	9152	17547	4432	12366	5610	7327	14359	19191	66870	15131	15119	37235	798	6029	8482	74503	1022	1293	6009	2329	6681	593	663	10688	13153	2204	18386	493	14471	10081	22111	6587	30504	24933	20662	3547	11031	24919	6043	24506	11152	16106	1345	3296	1325	1213	2106	11887	396	770	10031	15168	2542	1175	677	614	1353	3178	11711	5185	265	33261	1184	2027	16510	18814	400	1647	13012	2986	4958	1115	3881	14314	2329	2868	2151	1159	9016	2437	314	1544	472	12303
9.82_788.89	3584	12256	1719	5139	11401	3666	2410	4649	7206	7519	8341	7609	4596	4463	6885	4624	2649	4936	5703	3795	2166	3963	3229	2352	4849	4692	5965	6307	4425	3800	2569	2913	2876	6606	2049	4612	2348	1982	2910	2676	1590	2265	1978	2397	1609	1325	1550	2120	2177	1485	1603	2589	1477	1838	1906	1352	1447	1866	1472	2689	1911	4620	2444	2348	1582	4240	2540	1357	1707	1709	1917	2397	3772	1285	2012	1719	2763	1475	1625	1629	1187	4048	1506	3452	1322	2699	1709	1484	2720	2384	2477
9.89_871.74	10141	11690	1193	20202	2629	18986	3884	10137	15509	3262	13665	2264	1125	3896	13814	9753	9472	8176	13613	676	4086	9227	10331	868	585	1321	353	3773	1070	639	11362	15158	671	9123	602	1542	1388	11162	4586	4811	3221	2080	1903	1507	2791	4467	2630	1633	10412	1428	1265	1562	352	309	1717	541	909	1064	7787	1938	1252	735	481	863	237	1553	2615	432	4012	512	1806	9377	2792	345	1595	2013	743	241	759	2108	1812	1229	826	1673	452	1376	736	602	566	510	2072
9.97_871.75	9615	11856	1034	19611	3014	19143	3314	10441	13418	3259	13350	2182	1121	3978	12923	9321	9548	8722	14145	676	3986	9293	10874	738	584	1408	802	3918	1130	639	11522	15189	671	9208	500	1685	1502	11440	4829	4884	3051	2308	1778	1817	2768	4647	2650	1550	10168	1315	1404	1459	998	1124	1948	541	909	1262	7707	2039	932	714	574	530	1008	1434	2349	432	4206	512	1643	9370	2808	427	1527	1920	705	979	759	2349	1886	1179	707	1751	508	1273	606	535	566	628	1811
10.16_970.81	12864	5274	1228	19536	1868	19133	2945	4058	14960	3275	11666	2186	1219	5175	16931	5097	5374	5844	15577	473	2251	10720	12300	1115	236	462	460	2491	458	586	11444	6734	417	6789	403	2318	1636	11645	2728	3749	4050	1625	2272	1105	1613	1876	3689	1053	7257	469	1593	717	1055	1207	969	311	248	1205	8769	1368	487	526	318	609	742	1127	1917	242	1996	262	1769	13603	1400	234	736	1382	205	1258	679	1373	849	1565	655	1511	283	981	531	466	374	410	2218
10.16_969.81	19117	18482	1572	29716	5416	29031	6515	13738	21978	5387	18053	3561	1408	3566	25090	17020	21065	16993	38962	671	9004	15753	18882	1377	469	1414	252	5889	637	336	18983	33822	732	19324	718	3387	2137	17624	8750	7634	5860	4601	3311	1795	5045	4711	5658	2761	18456	1757	2403	2299	1439	2009	2916	273	824	1808	14115	3190	1569	816	334	854	2166	2715	5714	247	7302	249	2721	21164	4779	271	1736	2872	213	1385	1040	3976	3237	1884	310	1924	312	2149	284	555	491	207	3092
10.70_149.03	40302	39183	2593	3742	4794	3818	3299	2382	2337	3696	3579	2870	3677	4352	2385	3213	2317	4269	37974	2548	4705	2464	2771	2099	4146	39389	3877	3862	1560	3073	3285	5380	3306	2970	3439	4520	1789	47244	5088	1914	40087	2105	4226	38877	38867	4009	38903	4211	41339	3858	3961	2320	3802	3091	2985	4057	6535	4026	2314	3039	2183	39962	1921	4228	2979	2851	3138	2207	3955	2309	4527	2930	1588	3325	2701	1498	3170	1596	3443	3692	5705	3511	4158	4570	2959	3433	4014	2787	2979	2522	1719
10.70_279.16	50834	5619	3758	4940	3837	4901	5332	5273	2498	8198	3383	2091	3758	2501	4432	2256	3791	4873	5548	4236	4569	53781	2798	4088	3932	51757	5267	3814	3777	3645	4394	3989	3107	6506	2666	4664	2438	56575	4050	2556	4030	4903	5902	3471	3312	2676	3611	2687	4283	4162	51286	3078	3096	2465	4499	5227	3206	4867	2149	4328	4545	52343	3511	5227	5331	4019	4292	6891	4252	4733	2748	5063	4894	3401	3766	7306	5575	4055	5824	5908	3843	4304	2095	3584	4527	2380	2841	3161	4573	55475	3178
11.03_479.39	2121	2162	1594	969	1834	1542	12531	1214	3010	1395	2195	2428	1888	1790	2460	2559	1990	1577	2410	12531	1748	1835	1287	2310	2409	2166	1152	2357	2063	1726	2277	2547	12350	1398	1890	2508	1911	2523	1679	12709	1681	1716	11995	2130	13631	1724	1888	1346	1684	1529	2052	11910	1624	1703	2218	2335	1832	2297	11780	1569	1478	1539	1190	2017	1704	14040	1935	2663	13740	12718	2288	1594	2590	1183	1476	1400	1693	1224	2120	1540	2287	2243	1784	1205	2376	2521	2520	2560	1637	2069	2888
11.13_855.74	3211	5461	2616	3163	4070	3299	2678	3039	4910	9019	4772	8391	5598	3952	7216	3985	3012	4572	4453	4947	3850	3937	3207	3058	5915	8535	5725	4848	19105	2722	3424	2440	7420	5780	2669	3482	2701	4350	3640	3876	2586	2208	2154	1150	2374	2627	2462	2803	2895	1784	7009	2576	2465	2547	2772	3101	2224	2601	2535	2862	2664	3840	2776	2702	1875	4277	2697	2169	2266	2103	7221	3065	4993	1938	2814	2283	3211	2411	2141	2271	2352	5072	2063	3180	2181	2730	2200	4316	2293	4368	3413
11.14_478.39	6696	7933	6220	42935	6896	41300	6451	42188	5963	44297	42525	8087	39477	5683	45046	6448	5736	7872	4846	8017	42356	6730	8120	7194	42466	8601	6405	41680	5644	6261	6998	6867	5500	4967	41228	5622	7763	47599	6000	38590	40115	7164	8233	5635	5687	7997	40533	8315	6669	7403	10555	4780	42949	7737	10961	9550	41441	44704	6860	10204	8062	4915	5946	7825	41217	8228	7392	7721	5103	6667	44964	45502	7650	38834	5262	4617	7933	43703	37862	6243	6993	42846	6165	9772	4025	6936	5077	41548	9729	12885	9716
11.64_392.29	1617	10735	10121	1753	1698	675	10488	1519	1141	10365	1228	10560	1359	2715	10379	9716	2144	1061	1065	10216	1525	1459	860	10947	10464	1635	1785	1197	658	1302	899	9143	921	1698	1229	8812	8841	1137	8597	1107	1607	981	861	1375	875	8628	1103	1430	1632	890	900	1253	896	10180	9743	1144	866	1426	9910	1926	902	10782	1036	11275	1839	11038	1183	9615	1268	1004	1583	9850	10288	1107	1664	1438	10669	10114	10006	816	9822	9675	10260	10182	10400	10216	1718	1522	2502	2136	10704
11.92_730.66	7658	208013	10742	7893	185097	198327	9734	12453	193830	7887	201919	11169	11814	9076	203843	206673	7275	13533	7588	10797	200460	11991	200000	9926	12105	192191	4842	199955	8372	8875	5975	187445	175827	176988	6196	178171	13929	8150	13341	175957	8500	17945	180102	11693	6351	9402	14122	196319	195431	5109	196316	195137	7927	7857	3953	9516	194922	13685	195821	6054	6701	8251	6979	208753	187030	202827	10271	199271	1326	7681	8808	11379	10190	10013	8756	8212	3194	5109	10860	13473	12059	189396	205705	10670	6485	8099	11093	9690	199990	8350	204938
11.93_1077.02	118839	12079	5412	138811	8945	9823	35812	2381	131398	127929	5239	12913	3566	10160	131482	13894	4437	5315	123384	131112	9070	3623	134072	3083	8208	3297	4356	124938	128832	3268	3343	4457	2156	77258	75658	74253	74838	9900	4399	6629	72132	80549	6194	70626	1347	73958	72971	114276	18321	2667	110670	108549	4086	109201	6075	5650	115761	6566	100480	2378	5322	7224	122822	16838	115815	2269	9791	105904	7375	3116	7715	7427	7160	6918	7607	6977	1001	2872	8071	6715	5785	6591	135386	3637	127645	6180	2622	128749	5342	141218	4942
12.33_195.13	720	17446	1290	28515	980	1925	19472	3019	2168	2389	4036	1882	1738	713	10698	9446	2417	1714	843	2010	2302	3064	2100	3766	4321	1879	1995	1872	2290	3630	1851	2163	685	1742	2042	1055	745	1847	1190	1258	2410	3747	2168	699	1516	2007	996	1967	1844	6096	1346	2498	723	1866	1241	2226	2282	2651	1665	3378	1851	2357	1876	6342	1651	1728	1069	3835	1162	1275	3675	2452	2134	1986	1714	1884	2342	1820	2445	2380	2100	1795	3783	2039	2342	2211	711	1909	1971	13261	6547
12.39_1046.01	2650	6289	4424	22887	4287	1896	9620	3500	3328	2824	3240	1224	19740	1907	6981	1917	21010	2387	1977	3579	21896	4573	4501	4146	2205	2495	2109	2542	20898	8873	10477	1725	4504	1659	1892	11688	1405	1874	1618	1735	12024	12733	11787	2329	2024	2797	721	3679	1773	17338	18600	19668	18579	1743	1580	4193	2816	3295	17004	3325	21108	2583	935	1459	1167	2725	857	18980	2148	3644	3448	2342	22179	19837	1608	1625	5664	21446	2278	3380	3312	3799	2380	3525	2525	2690	26517	2646	3465	23544	3668
12.46_195.13	953	23293	407	36753	1113	1051	25703	3931	801	2457	6108	2294	674	1819	14053	14042	2876	268	824	2304	788	3480	701	5262	7560	603	492	489	504	6588	634	2617	685	971	636	1166	1997	1974	707	747	2651	4185	3126	2026	2070	678	489	950	2221	8440	736	831	634	2238	826	736	871	3432	545	4589	2156	2594	1924	27808	391	5152	974	5621	2629	738	11606	487	874	563	379	737	695	766	706	613	895	772	5286	989	2707	730	2621	2261	453	19437	8792
4.03_506.42	2489	6249	6652	2933	12104	1368	1740	2760	4828	4007	1320	4125	4727	10042	2592	7926	9686	9602	9612	2056	6756	2843	2258	2743	8564	12188	4047	5684	8833	3166	6205	9505	14696	10514	1163	9013	8294	1902	4181	12052	4142	1347	9423	6618	9110	2811	8338	1528	4306	6228	4637	7985	4201	5201	3691	7988	3112	2921	13208	2155	10303	5529	4102	3452	6611	3840	7309	2665	6723	4874	3687	11341	4364	2272	7236	24841	4646	6751	7707	9121	7456	4334	11205	3176	4026	3379	3903	7398	4330	1560	5783
3.95_506.42	2600	6582	14997	3012	12700	5539	1740	2760	5162	5372	2820	2340	4560	12678	5053	10133	11893	6845	10385	1535	8476	3197	2132	2743	9604	15407	4198	9567	11812	2353	8120	12481	17351	13752	1163	10590	9922	1677	4740	11343	3930	1754	9213	4959	11174	6024	8046	1819	7125	12394	8148	9890	11437	5949	5194	10501	2967	2763	12219	2008	12409	4439	5574	1494	8344	3595	13321	2655	6327	7337	3687	8929	5199	2391	3871	38866	4398	7775	7120	10552	8230	12559	5421	3133	4040	3379	6211	9239	10612	18436	5325
9.70_942.78	33986	9038	2915	49107	1672	48720	6034	2667	3795	1650	31432	2472	540	15320	10925	30365	37951	2951	65338	1075	1054	2487	33657	2544	719	542	554	12260	1098	500	32213	9058	1060	33717	1061	1489	479	8850	14666	1093	10709	839	6668	1244	1354	8119	2406	1032	32310	3432	1154	4099	308	3321	5352	598	1275	3776	24666	816	2844	1289	641	1309	795	605	1199	323	1367	454	1472	35685	8638	457	774	5497	1636	2274	1453	7415	6118	1110	1686	1088	447	593	1057	1100	812	847	1515
10.36_900.77	4913	9336	470	21173	2754	19753	3345	10183	8094	3359	6355	1115	456	3894	13581	7657	4933	2593	3722	818	1493	3224	10808	875	787	636	592	3693	1525	723	6081	15698	569	9477	589	2066	443	8189	2351	5315	1146	1099	1885	339	2754	1504	2239	470	6958	1235	376	719	1104	1194	775	641	661	398	2782	2309	1255	679	492	645	409	1792	1080	441	1940	567	1714	3400	1815	438	1434	1772	858	440	855	2189	1349	648	831	766	393	1332	704	713	531	723	1938
3.48_681.50	6995	8562	3767	6125	6577	5230	3580	3772	8417	4613	7025	4893	2021	2885	5806	4029	7274	4511	4453	2581	2533	4615	4997	1501	3003	3118	2452	3031	9494	5102	4891	5456	6304	35951	5351	6440	4849	4851	27942	8310	3981	4147	5069	4650	5225	4643	4959	4888	5569	4408	3454	5401	4106	5272	4709	3184	3700	4416	5319	7562	3581	5420	3877	5414	4069	9151	6530	2112	4473	3157	4675	6928	4481	2797	3330	4059	3566	3532	4639	6640	3585	8141	4627	4980	3177	4868	9210	3006	3700	4944	6540
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3.28_471.11	3215	14431	426	7044	196	21681	3347	9396	43984	11384	22761	18377	3678	612	20443	20698	40847	16706	10802		2307	51858	31745			83	317	19019	115	123	28687	25038		46804	193	8192	2246	26269	12345	26920	19268	10424	18719	5717	11997	6520	32709	19337	43991	1131	1734	6993	5361	21291	11837		89	18833	43484	15287	838	207	105	260	4219	2652	56291		49455	129	6066	38907	3033	61		15789	184	146	102	312	11897	2381		16039	82	11636	125		142	186	7180
0.99_141.96	2991	7941	2173		2323	3183	8707		1093		654	2952	2654	3309	5398	5731			2850		3944	3991	1044	4490	3941		348	2623	2876	4537	3238	2786	3050	3276	619	3476	434		3333		3358	3260	4178	3404	3093	3283	63	3287	3920	4226	740	519	4256	537		3093		3504	2438	3709	2997	286	3020	1069	3683	4201	3555	4002			4758	4369	3588		3224	2705	267	3035	3420	3803	2827	41		4121	3520			3197	3541	6892	4244
5.63_1197.81	5133	3677	5210		3674	4668		3207	4337	3648	3314	3761	3471		3472		4861	2921	3015	2239		2449	125	2775	3728	2689	3099	3204	3079	4357	4061		3470	3914	4005	3475	3949	3707	3948	3506	4095	4402	954	3250	3274		3319	4507		3503	4998	4257	4000	3960	3251		4305	3258	2997	3185	4623	6323	5469	6187	4149		5059			5790	6377	5292	3596	3339	5594	4736	5804	5128	5346	6940	5251	5488			3482	4043	4280	4277	4132	5218	6084
9.17_929.70	11942	15520	1256	20155	3061		11926	3199	16964	6791	3324	4996	2926	8704			15022	13411		5371	3348	14569		2835	4145	1705	3069	6301	2518	394			1413		3731	5442	3806			4201	4908	5876	1778	2903		2766		4256		3226	752	724	4177	3221	5955	2413	312	1001	10344	871	3379	6405	4499	2223	1089	1288	6145	6315	2258	7707	10466	16388	3702	5606	1187	4315	1252	734	1343	1527		1393	289	4137	338	3871	1527	1147	1062	1294	992
0.65_244.22	2765	359	8878		4043	7991		846	1846	4854	520	1533		2569	5805	3328	1243		9814	329	3922		1245		2055	2276	1849	1070	3645	215		2174	2859		7763	2398	6410	5690		247	4385	199	2369	15828	2829	1949	4236	144	12782		3110	1536	5196	8267	5218	1956	1418	2557		1101	9289	6328		2159		536	3462		2942		6457	1030	1399	712	12375		1565			2039	9137	6079	10651	1434	93		4086	3968	6029	3971	
3.28_473.10	2634	9997	355	5256	323	14282	2607	6153	29905	7672	14351	11817	2638	89	13228	13743	26621	10509	6725		1701	32733	20580				177	12085			19043	3662		31945	123	5047	1281	16432	8193	16626	12331	6358	1578	3800	7720	882	4636	13147	27185	792	1174	4316	4059	14343	7722			12742	28149	10088	335				2996	308	35941		32432		4192	25038	1973			10407			161		8147	1566	169	10726	197	1780					4534
1.32_487.36	105	24088	317	605	256		321	205	368		491	132	195		158					231	674	450	183	177	482	315			231	541	255	246	298	752		449		260		346	1837		277	178	286				200	269	310	286	132		215		139	225	144	177		1070		116	285	170	335	68	247	346	265	195	462	210	754	450	208		452	410450	348	410			126	502	299	322277	273		241
3.28_409.19	2697	7640	449	5421	343	13642	1749	5551	36888	7336	14253	10448	2199	88	11183	12287	29408	10600	7010		2076	40074	21708		133			12314	137		19732	15708		43294		4654	1559	16507	6909	16878	10929	6058	11270	2895	6405	3691	14777	11561	30646	106	359	3397	3845	13149	6722			10335	31572	9507	325	274			2112	539	40803		42569		4679	26254	1478			9420					5303	1401		8052		6070		159			5244
0.55_391.30	820		9399		1386	4652			25813		2936		28136	1016	4292	38	709			370					1081	9804	1445	1057	12769	697	2859	2262	1647	1817	535	529	84	11993		5937	3277		15491		618		597	304	14387	941		5928	966	6783	587	18473			861	507	8197	11305	2454		1795	515	1169		14524	766		895	2170		4249		411	529	1588	23290		1436		275	2188		8684	7788	613	1039	
1.32_500.37	658	310171	460	133	436		324	277	527		649			424	263		372	379		219	1312				792	414		441		235		325	487	1351	169	824	575			655	3258					282		330	327	312	420	457	315		320	513	242	252			516	1353	398	265	311	466	652	178		261	350	258	160	318	1077	4235			751	631136		588	666			490	456	535761	390	435	
0.76_195.12	2314	15535			1759	2458		4408	3519	2714	5089	3321	2429	2376			2835		2894	3531		3720	3132		7135						3021			2795	3284	2732	2915	2770		2769			235	2599	2684	2468		2928	2420	7167		2931		3161	4581		3000	3417	2562	4551	3247	2898	2657			4931	2882		200	2052		2959	2870	2449	2785	2512		3176	2864	3140	525		4638	4089	2935		2735	3011	3413		
2.04_512.41		8450		1297	4721	4111		2363	854	3740	1545	3950	2646		1026		1310	3868	3585	3988	3287	4033		3266	3782	5886	2655	2581	8376	2557				16964		3174	4335			4270		828	5685									3458	3732		1168	2873			2494	3598		3875	2451	2544		7702	1293	1891	5338	6199	1688	432	3424	2016	3183	8725			1058	4974		4362	2777	597	3422	543	7949	500	867	3683	2321
3.45_554.22	8783	2095	445	1377	421	2983	214	1322	6345	8258	8548	2715	652		3504	3899	44978	1507	1192		339	11198	7353					3586			5189	7255		10055		1064		3378	2357	2899	7136	1610	2594	573	3056	693	13342	3414	5769			1134	715	2074	3144			1642	6550	6009					270	46	12882		6490			6754				3412			123	326	1192	275	132	3611		2835					30958
9.14_929.72	12067	15520	527	20155		9924			16464	6791		5079		8704	18231	13593	16626	13411	18503		10178	14569	8838			1710		6301		729	10731	3004		8666				1996	6391	7022	5508	5484	2828	2903	4916	3997	4562		7795		2735						295	2950	11441	3970					2174		7192					17213	4183		1568			1444	666		3186	2190						697	276		
1.84_403.36	3217	6685	1205	4987					5074		14275	6919	1148	1145	1510	1560		2448					1029		2094	5181			25748	3422	2097	1398	2024	4854		2197	6455	1906	910	2822	561	774		793	55		733	2342	519				13407	1329	1508		495		1335	9130			2345		1365			1898					1488	464	1939	1555		2758			540	1407			1524		1224				
0.62_195.12			2279			2887	21766	4047			5130	2853		2432		10314					3168		3552					2957	2838	6997		669	2745	2810	3217		3012	2281	3274			4316	2634		2782		3113	3345		7359	2721			2939		3201		4549	3163	5309				18316	2815	5495	3395		394	1981		3254	2442			3645		3197	3059	2969		2411		3968	3659		3431	2489	3443		
6.19_751.78	138212	127581	117996	1213	120971	1104	734				116541		1043			1201	117574	1999	97855		108304		1374					2028	1040		673					2720		632	1367		694						717	874	931	899		761		1067	1656	810		605	1166			132277		1026	77297	102422			127316	113732		113653			133823	120171	1268	1185		113072					870		897		924		951
1.55_195.12	2066	11508		17379	1468	1872	15676	3052			4416		2179	1908	6895		2221				2443	3264	2742	4803	5129			2573			1947	2451				2340	2058	2252	2578		2784				2084		2038			5215								3166		3401	2441			12488	2281		2218		1983			2652	1956	2282	2289		2046		2191				3810			2225			2032		
8.48_280.17		7209	7470	7630	7001	7989		7542				7812	7224		7554			7408		8440		8272	6528			6974	446					6892		7130		7695		7013		7163	7703							6143	7820			7353		7211	7359	6762		7712	7010				7834	7647	7130	7631		7308	6636		7297								961				7549		8287			6579		7955	
3.85_338.50			1092	1005			428			1074		1201				975								1217	1254		1201	796				103932			598	1482		1201												873		1101	160459				118850	830		790	824		1780			781		449						899				1334		611			1417	1108		1349	1501	1563	927	755	1010
7.71_680.58_7.71_685.54	148							480	304	293	142	135				780					449		203			115	432	514		65043							136			209	246				172		175894						207	387						250				226		236		206						196					200						142				149		
1.13_195.12			1692				20296				4058		2173			8894		2597	2078	2412		3996		6503	5782		2228						2811				2133			2660				2885	2523	2569		2279	2561				2928	2639		2519	2130		2342		2511		2622			4905	3518				8442			2731	2086										2803			2459			
3.55_458.35_3.55_463.30			281			244	220						174	277	311				260					1636						170284			266	405				187	392							184	372491	374			267			298								290	283		240	187				525									430								278	159			
0.66_228.23			6453			7424		535							444	2615	1021		8957																		6533	4729				854		13080	4052	2486			9624		3075			7676	4567		931	316			6416	9656					1005				6382			374	4185						5080		6895				1616		3978	2260	
7.97_131.16	15098	14804	14026			14892											15458		13930		14210		15126					13336														14331			14292	13795																15714			14765					13425			16118					13742	14066		13763		15096		13735	15074	14044				
11.52_132.14				2633											2750	3460	2810				2478			3746	3579				3330	3047	2419	2838										3268		3362						3224	3534		3038		3000								3043										2987	2391	3189	2577		3213							3064						
3.14_715.61		6695		7432				2711						1362	4433		4922			2379	5614					1672							5293			6333																	4351										4289						3685		5834	2965	2766		2743			2484			2299									5129	6874
8.83_225.21							4679					4030					3772			3341	3363				3724				3208								3898	3873												3648					3736									4874							4059							3854						3173	3870	4196					3213
9.28_479.39		5225	4813	5721				5600		5859	5796		5250	5322										5317															4838	5394				5805				5954					5134					5004	5267			5175						5557						4737								4955									
4.14_963.71		4373		46257			10802								178				116		154			181		147				160	158		121						81																						218					162									211				177				118		88				183		
9.35_280.17	7145	7242		8554		8091																				7830	7863		7002	8472			8048					7251			7653	8516										7715	8344																7965					7535		7577		8779				8498		8470	7435	8385					
8.77_302.15				3049												2755		3413			3182							2886					3437			3524															2782										3068									2822	2909		3407															3341			
6.54_392.29					3187	3756										5122				4303				4920	4295					4439					4121		3928				3986		4405			4458		3943				4252												3996		4644		4455	4139																			4238			
12.24_1093.99									2922					3852									3763		3237		4181		4856				2691	7162	2861						2865		4049		2932						3699																	4047		4345		7239	4836				3809								4203						6244
1.31_443.29	365	86031					103	267	278																										158														102					200								413												121	144	818				146887					121			116108			
0.57_324.21										289						285		435		50914				334										47424	439		49646										285									480				88213																					607			402					446	16852	
4.86_516.43_4.86_521.38									185	131																			197	32585	99					199	152	172									69359		238					91								152	138																		175							133			
1.51_478.32			128		187								138					380														125		172			384			156								139			651								191								268		364			305					98		187303	892											
5.53_391.28								14051										13720							14617			12742		14343		13859			14643							14896				13304		13883																						13582								13279	13578												
6.18_766.84				4386								3552					6203			7059							5603		8371									4369																																6438	8312							7651		9430			5344					1793			
1.31_399.42		126848																		84	176										66		109	216																																		63	99							713				510040	152							304639			
0.57_237.11_0.57_259.09											488									280013			291											259448			281071																							508459		1159				1751		442									326								1697	468				91764	
6.26_665.46				1387										5859						2550			4074	2503			5822															2554	4768					1307								3540																4738															1699				
7.26_492.41								3034	3677		3843							3122																			3201									2830	4898				3357								3458												3785										3366										3290
0.57_473.20_0.57_495.18					435															40608								67				78		25535			33098			108	87						108													95371							190													72										4155	
1.32_299.16		29541																			272													141						154									170															135																120509						202		75230		237	
1.33_400.26		395751	201																		1219							193			401			1361							3191				206	269														264																	421			1372719											
1.31_819.48		420158							81																			52					58																							83						168					57									957	51			1026827								683655		50	
0.81_149.06		3624		2707																	5629													5237		4013																				5424											8178			3683						55286							3917								4699
1.32_472.34		23359																									103						173						104																				96																					51072						110	124	41333			
4.12_489.40		4305	85	4235			12538					123																												218																280								6164																											
6.18_663.67	183183	144985							122078		124567						131924																							1036																						161789							146365						175368																
0.57_338.22					396															20357											288			20461			21189																							36667														235															218	7011	
4.12_493.35	4732	20302		96165			49296								3020																																																	26488								2737																		5150	
1.37_486.54																				57	104																					101																					57						67											100492		62						1404			
0.57_295.16																				4011														4826			4382			694								299												5533																						251				573				2939	
4.86_537.36																	99										186			9983															153		16384	157							145																			63																	
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	retention_times	quantified m/z	PubChem ID	KEGG ID	InChI Key	Species
1_CE (22:1) iSTD	11.93	729.6564			SQHUGNAFKZZXOT-JWTURFAQSA-N	[M+NH4]+_[M+Na]+
1_Ceramide C17 iSTD	6.23	552.5363			ICWGMOFDULMCFL-QKSCFGQVSA-N	[M+H-H2O]+_[M+Na]+_[M+H]+
1_Cholesterol d7 iSTD	5.05	376.3967			HVYWMOMLDIMFJA-IFAPJKRJSA-N	[M-H2O+H]+
1_CUDA (pos) iSTD	0.8	341.2812			HPTJABJPZMULFH-UHFFFAOYSA-N	[M+H]+
1_DG (12:0/12:0/0:0) iSTD	4.42	479.3736			OQQOAWVKVDAJOI-VWLOTQADSA-N	[M+NH4]+_[M+Na]+
1_DG (18:1/2:0/0:0) iSTD	3.26	421.2955			PWTCCMJTPHCGMS-YRBAHSOBSA-N	[M+NH4]+_[M+Na]+
1_LPC (17:0) iSTD	1.96	510.3572			SRRQPVVYXBTRQK-XMMPIXPASA-N	[M+H]+
1_LPE (17:1) iSTD	1.43	466.2938			LNJNONCNASQZOB-HEDKFQSOSA-N	[M+H]+
1_MG (17:0/0:0/0:0) iSTD	3.15	367.2836			SVUQHVRAGMNPLW-UHFFFAOYSA-N	[M+H]+_[M+NH4]+_[M+Na]+
1_PC (25:0) iSTD	3.64	636.4604			FCTBVSCBBWKZML-WJOKGBTCSA-N	[M+H]+
1_PE (17:0/17:0) iSTD	6.57	720.5549			YSFFAUPDXKTJMR-DIPNUNPCSA-N	[M+H]+
1_SM (d35:1) iSTD	5.31	717.5911			YMQZQHIESOAPQH-JXGHDCMNSA-N	[M+H]+
1_Sphingosine (d17:1) iSTD	1.12	286.275			RBEJCQPPFCKTRZ-LHMZYYNSSA-N	[M+H]+
1_TG (17:0/17:1/17:0) d5 iSTD	11.3	874.7894			OWYYELCHNALRQZ-ADIIQMQPSA-N	[M+NH4]+_[M+Na]+
CE (18:2)	10.7	671.5745			NAACPBBQTFFYQB-LJAITQKLSA-N	[M+Na]+
Cholesterol	5.07	369.353			HVYWMOMLDIMFJA-DPAQBDIFSA-N	[M+H]+
DG (36:2)	7.24	643.5275			AFSHUZFNMVJNKX-LLWMBOQKSA-N	[M+Na]+
LPC (o-16:0)	1.88	482.3611			VLBPIWYTPAXCFJ-DEOSSOPVSA-N	[M+H]+
PC (30:0)	5.05	706.5396			RFVFQQWKPSOBED-PSXMRANNSA-N	[M+H]+
PC (32:1)	5.13	732.5542			QIBZFHLFHCIUOT-NPBIGWJUSA-N	[M+H]+
PC (34:1)	5.79	760.5861			WTJKGGKOPKCXLL-VYOBOKEXSA-N	[M+H]+
PC (34:2)	5.28	758.5698			JLPULHDHAOZNQI-ZTIMHPMXSA-N	[M+H]+
PC (36:1)	6.46	788.6164			ATHVAWFAEPLPPQ-VRDBWYNSSA-N	[M+H]+
PC (36:2)	5.94	786.6008			SNKAWJBJQDLSFF-NVKMUCNASA-N	[M+H]+
PC (36:3) B	5.44	784.585			WZCLAXMADUBPSG-RIXBAXMTSA-	[M+H]+
PC (36:4) B	5.18	782.57			IIZPXYDJLKNOIY-JXPKJXOSSA-N	[M+H]+
PC (36:4) C	5.78	782.5678			IIZPXYDJLKNOIY-JXPKJXOSSA-N	[M+H]+
PC (38:4) A	5.83	810.6025			PSVRFUPOQYJOOZ-QNPWAGBNSA-N	[M+H]+_[M+Na]+
PC (38:5) A	5.26	808.5785			SUACBSWYGWBPFC-GPUJSUHJSA-N	[M+H]+
PC (38:6) A	5.03	806.5698			PLZBTDKJYHXIEW-DZUXOTHRSA-N	[M+H]+
PC (p-34:0) or PC (o-34:1)	6.18	746.602			QCGUXAIDEOWPBV-SNKLRXETSA-N	[M+H]+
PC 32:0;	5.78	734.5668			KILNVBDSWZSGLL-UHFFFAOYNA-N	[M+H]+
SM (d36:1)	5.66	731.6061			LKQLRGMMMAHREN-YJFXYUILSA-N	[M+H]+
SM (d36:2)	5.07	729.5903			NBEADXWAAWCCDG-QDDWGVBQSA-N	[M+H]+
SM (d42:2) A	7.03	813.6842			DACOGJMBYLZYDH-GXJPFUDISA-N	[M+H]+
TG (46:1)	10.28	794.7238			RSDIQTNCDWUNDP-VHXPQNKSSA-N	[M+NH4]+_[M+Na]+
TG (48:1)	10.7	827.7114			FEKLSEFRUGWUOS-DLOIZKPKSA-N	[M+NH4]+_[M+Na]+
TG (48:2)	10.33	820.7408			RUOVJPPUXXFZPC-YZEIBMOJSA-N	[M+NH4]+_[M+Na]+
TG (49:1)	10.91	836.771			VYYGQDOPVVYUKW-UKFBYESTSA-N	[M+NH4]+_[M+Na]+
TG (49:2)	10.53	839.7113			QZYSUBAQYSVFNX-PSMULLBHSA-N	[M+Na]+
TG (50:2)	10.74	848.7718			QEZWFCZNHWUARW-XQCAQTCHSA-N	[M+NH4]+_[M+Na]+
TG (51:2)	10.95	867.7421			NSNSZGBCOIKUBU-SZOKBDNISA-N	[M+Na]+
TG (52:1)	11.5	878.817			NPCZZYKITFKRQZ-RFBIWTDZSA-N	[M+NH4]+
TG (52:2)	11.14	876.8021			TXMWKTABZBAJCW-QLHBUVOUSA-N	[M+NH4]+_[M+Na]+
TG (52:3)	10.78	874.786			DQXQIWIQYYEGLG-MMWLGPPDSA-N	[M+NH4]+_[M+Na]+
TG (52:4)	10.4	877.728			WHSWXEYWNPTUPW-HNJDVRDNSA-N	[M+NH4]+_[M+Na]+
TG (54:2)	11.52	904.8317			WUUWGORPQFKFQN-XDVOZUNOSA-N	[M+NH4]+_[M+Na]+
TG (54:3)	11.16	907.7734			PHYFQTYBJUILEZ-IUPFWZBJSA-N	[M+Na]+
TG (54:4)	10.8	900.8017			BRLGHZXETDWABO-NOFIOOQLSA-N	[M+NH4]+_[M+Na]+
TG (54:5) A	10.43	903.7415			VVEBTVMJPTZDHO-YQFZQLSNSA-N	[M+Na]+
TG (56:2)	11.86	932.8646			PDEQUPGHMOMBFC-FYEHETCMSA-N	[M+NH4]+
TG (58:2)	12	960.8884			NFQQJRGJJVQGAV-MEADVOAOSA-N?	[M+NH4]+
TG (60:2)	12.09	988.9261			QPNVLDQSHXVPMG-JMYPUKFOSA-N	[M+NH4]+
TG 54:0; TG(18:0/18:0/18:0);	11.98	908.8644			DCXXMTOCNZCJGO-UHFFFAOYSA-N	[M+NH4]+
3.54_279.16	3.54	279.1607				[M+H]+
10.77_895.72	10.77	895.7167				[M+H]+
10.76_369.35	10.76	369.3538				[M+H]+
10.48_808.74	10.48	808.7408				[M+H]+
5.78_850.55	5.78	850.5543				[M+H]+
9.20_913.75	9.2	913.7468				[M+H]+
5.79_783.57	5.79	783.5709				[M+H]+
5.79_761.59	5.79	761.5893				[M+H]+
0.56_244.19_0.56_266.17	0.56	244.1917				[M+H]+_[M+Na]+
0.57_214.18_0.57_236.16	0.57	214.1809				[M+H]+_[M+Na]+
0.70_343.30_0.70_365.28	0.7	343.2964				[M+H]+_[M+Na]+
0.83_371.33_0.83_393.31	0.83	371.3271				[M+H]+_[M+Na]+
1.32_399.25_1.31_421.23	1.32	399.2516				[M+H]+_[M+Na]+
3.13_244.19_3.13_266.17	3.13	244.1922				[M+H]+_[M+Na]+
3.28_371.32_3.29_393.30	3.29	371.3176				[M+H]+_[M+Na]+
3.84_338.34_3.84_360.33	3.84	360.3258				[M+H]+_[M+Na]+
3.96_419.32_3.96_441.30	3.96	419.3169				[M+H]+_[M+Na]+
0.55_207.16_0.56_224.19	0.56	207.16				[M+H]+_[M+NH4]+
0.83_332.28_0.83_337.24	0.83	332.2799				[M+NH4]+_[M+Na]+
3.06_518.37_3.06_523.33	3.06	523.3251				[M+NH4]+_[M+Na]+
5.09_598.45_5.09_603.41	5.09	598.4507				[M+NH4]+_[M+Na]+
8.63_908.79_8.62_913.75	8.63	908.7905				[M+NH4]+_[M+Na]+
8.66_881.76_8.66_886.72	8.66	881.7604				[M+NH4]+_[M+Na]+
8.66_880.76_8.67_885.72	8.67	880.7595				[M+NH4]+_[M+Na]+
9.69_936.82_9.70_941.78	9.7	936.8225				[M+NH4]+_[M+Na]+
3.01_228.20	3.01	228.1972				[M+H]+
3.01_226.18	3.01	226.1818				[M+H]+
3.13_228.20	3.13	228.1975				[M+H]+
3.13_226.18	3.13	226.1819				[M+H]+
3.13_408.31	3.13	408.3098				[M+H]+
2.96_441.13	2.96	441.1318				[M+H]+
2.96_439.13	2.96	439.1348				[M+H]+
3.86_507.43	3.86	507.4284				[M+H]+
3.87_506.42	3.87	506.4217				[M+H]+
3.84_675.68	3.84	675.6769				[M+H]+
3.84_677.68	3.84	677.6802				[M+H]+
7.32_928.73	7.32	928.7294				[M+H]+
7.32_927.73	7.32	927.7255				[M+H]+
5.99_942.71	5.99	942.7114				[M+H]+
5.99_941.71	5.99	941.7053				[M+H]+
3.96_442.30	3.96	442.302				[M+H]+
3.88_442.30	3.88	442.3024				[M+H]+
3.91_419.32	3.91	419.3163				[M+H]+
3.86_419.32	3.86	419.3171				[M+H]+
10.78_927.80	10.78	927.7999				[M+H]+
10.80_927.81	10.8	927.8076				[M+H]+
9.20_930.72	9.2	930.7189				[M+H]+
6.14_681.48	6.14	681.4812				[M+H]+
0.55_254.14	0.55	254.1384				[M+H]+
0.56_245.19	0.56	245.1879				[M+H]+
0.57_151.10	0.57	151.0984				[M+H]+
0.62_261.11	0.62	261.1118				[M+H]+
0.67_192.14	0.67	192.1398				[M+H]+
0.67_316.93	0.67	316.9303				[M+H]+
0.71_225.20	0.71	225.1973				[M+H]+
0.74_274.27	0.74	274.2745				[M+H]+
0.76_437.20	0.76	437.1953				[M+H]+
0.77_392.30	0.77	392.3016				[M+H]+
0.81_337.11	0.81	337.1057				[M+H]+
0.83_448.33	0.83	448.3277				[M+H]+
0.83_191.18	0.83	191.1801				[M+H]+
0.83_230.25	0.83	230.2488				[M+H]+
0.83_209.19	0.83	209.1908				[M+H]+
1.31_628.35	1.31	628.3459				[M+H]+
1.32_258.28	1.32	258.2799				[M+H]+
1.60_332.33	1.6	332.332				[M+H]+
1.67_425.21	1.67	425.2148				[M+H]+
1.80_511.36	1.8	511.359				[M+H]+
1.86_402.36	1.86	402.3583				[M+H]+
1.88_298.35	1.88	298.3476				[M+H]+
2.50_369.38	2.5	369.3845				[M+H]+
2.71_430.39	2.71	430.3898				[M+H]+
2.92_452.39	2.92	452.395				[M+H]+
2.96_480.16	2.96	480.1602				[M+H]+
2.97_379.28	2.97	379.2827				[M+H]+
3.01_430.37	3.01	430.3663				[M+H]+
3.01_270.24	3.01	270.2437				[M+H]+
3.01_424.28	3.01	424.2838				[M+H]+
3.01_419.36	3.01	419.3613				[M+H]+
3.01_474.44	3.01	474.4354				[M+H]+
3.01_487.45	3.01	487.4474				[M+H]+
3.01_444.38	3.01	444.3804				[M+H]+
3.01_227.21	3.01	227.2069				[M+H]+
3.01_473.43	3.01	473.4319				[M+H]+
3.01_408.31	3.01	408.3094				[M+H]+
3.01_409.31	3.01	409.3137				[M+H]+
3.09_480.31	3.09	480.313				[M+H]+
3.12_473.43	3.12	473.4319				[M+H]+
3.12_642.52	3.12	642.5153				[M+H]+
3.12_487.45	3.12	487.4474				[M+H]+
3.12_459.42	3.12	459.4156				[M+H]+
3.12_474.43	3.12	474.4341				[M+H]+
3.13_221.18	3.13	221.1763				[M+H]+
3.14_598.49	3.14	598.4895				[M+H]+
3.15_554.46	3.15	554.4636				[M+H]+
3.17_601.44	3.17	601.441				[M+H]+
3.17_510.44	3.17	510.4362				[M+H]+
3.18_579.43	3.18	579.4263				[M+H]+
3.19_466.41	3.19	466.4103				[M+H]+
3.19_557.41	3.19	557.4146				[M+H]+
3.20_340.40	3.2	340.3951				[M+H]+
3.38_371.32	3.38	371.3169				[M+H]+
3.43_336.33	3.43	336.3271				[M+H]+
3.46_725.52	3.46	725.5214				[M+H]+
3.47_703.51	3.47	703.5082				[M+H]+
3.50_659.48	3.5	659.4821				[M+H]+
3.50_659.99	3.5	659.985				[M+H]+
3.51_637.47	3.51	637.4696				[M+H]+
3.52_615.46	3.52	615.4562				[M+H]+
3.54_414.27	3.54	414.2716				[M+H]+
3.54_593.44	3.54	593.4438				[M+H]+
3.56_571.43	3.56	571.4307				[M+H]+
3.58_369.43	3.58	369.4303				[M+H]+
3.64_368.43	3.64	368.4267				[M+H]+
3.84_361.33	3.84	361.3285				[M+H]+
3.86_992.74	3.86	992.7391				[M+H]+
3.89_441.30	3.89	441.2987				[M+H]+
3.89_997.69	3.89	997.6948				[M+H]+
3.97_859.61	3.97	859.606				[M+H]+
3.97_457.27	3.97	457.2725				[M+H]+
4.00_420.32	4	420.3203				[M+H]+
4.07_419.32	4.07	419.3157				[M+H]+
4.68_553.39	4.68	553.3903				[M+H]+
4.81_983.72	4.81	983.7158				[M+H]+
5.02_703.58	5.02	703.5751				[M+H]+
5.03_494.57	5.03	494.5664				[M+H]+
5.04_549.40	5.04	549.3955				[M+H]+
5.09_619.38	5.09	619.3806				[M+H]+
5.34_674.55	5.34	674.5465				[M+H]+
5.65_1195.82	5.65	1195.8203				[M+H]+
5.66_523.60	5.66	523.6012				[M+H]+
5.66_522.60	5.66	522.5982				[M+H]+
5.80_762.59	5.8	762.5911				[M+H]+
5.81_580.54	5.81	580.5402				[M+H]+
5.82_786.60	5.82	786.6003				[M+H]+
5.93_668.62	5.93	668.6189				[M+H]+
6.16_765.58	6.16	765.5803				[M+H]+
6.16_666.46	6.16	666.4637				[M+H]+
6.17_767.58	6.17	767.5845				[M+H]+
6.28_552.63	6.28	552.631				[M+H]+
6.31_551.63	6.31	551.6334				[M+H]+
6.50_684.20	6.5	684.203				[M+H]+
6.55_666.64	6.55	666.6392				[M+H]+
6.59_696.65	6.59	696.6514				[M+H]+
6.60_969.74	6.6	969.736				[M+H]+
6.97_578.66	6.97	578.6602				[M+H]+
7.14_758.22	7.14	758.2214				[M+H]+
7.27_414.27	7.27	414.2703				[M+H]+
7.87_648.46	7.87	648.4634				[M+H]+
7.87_649.47	7.87	649.4659				[M+H]+
7.92_955.76	7.92	955.7563				[M+H]+
8.25_906.26	8.25	906.2589				[M+H]+
8.63_914.75	8.63	914.7515				[M+H]+
8.67_887.72	8.67	887.7228				[M+H]+
8.67_901.69	8.67	901.6898				[M+H]+
8.73_980.28	8.73	980.2773				[M+H]+
9.15_941.78	9.15	941.7774				[M+H]+
9.16_1055.30	9.16	1055.2965				[M+H]+
9.20_915.75	9.2	915.7531				[M+H]+
9.20_914.75	9.2	914.7513				[M+H]+
9.82_788.89	9.82	788.8935				[M+H]+
9.89_871.74	9.89	871.7369				[M+H]+
9.97_871.75	9.97	871.7479				[M+H]+
10.16_970.81	10.16	970.8113				[M+H]+
10.16_969.81	10.16	969.8084				[M+H]+
10.70_149.03	10.7	149.027				[M+H]+
10.70_279.16	10.7	279.1633				[M+H]+
11.03_479.39	11.03	479.3934				[M+H]+
11.13_855.74	11.13	855.7432				[M+H]+
11.14_478.39	11.14	478.3919				[M+H]+
11.64_392.29	11.64	392.29				[M+H]+
11.92_730.66	11.92	730.6591				[M+H]+
11.93_1077.02	11.93	1077.0186				[M+H]+
12.33_195.13	12.33	195.1278				[M+H]+
12.39_1046.01	12.39	1046.0078				[M+H]+
12.46_195.13	12.46	195.1275				[M+H]+
4.03_506.42	4.03	506.421				[M+H]+
3.95_506.42	3.95	506.4211				[M+H]+
9.70_942.78	9.7	942.7812				[M+H]+
10.36_900.77	10.36	900.7722				[M+H]+
3.48_681.50	3.48	681.4952				[M+H]+
9.20_908.79	9.2	908.7908				[M+H]+
0.83_135.12	0.83	135.1167				[M+H]+
3.11_686.54	3.11	686.5381				[M+H]+
3.84_339.35	3.84	339.3466				[M+H]+
3.84_340.35	3.84	340.3501				[M+H]+
3.85_472.11	3.85	472.1141				[M+H]+
4.43_366.37	4.43	366.3719				[M+H]+
5.10_604.41	5.1	604.4083				[M+H]+
10.36_899.77	10.36	899.7695				[M+H]+
9.21_929.72	9.21	929.7175				[M+H]+
0.63_297.13	0.63	297.1327				[M+H]+
3.13_229.20	3.13	229.2				[M+H]+
3.13_270.24	3.13	270.2446				[M+H]+
3.15_533.28	3.15	533.2822				[M+H]+
3.24_382.31	3.24	382.3056				[M+H]+
3.30_372.32	3.3	372.321				[M+H]+
10.60_997.84	10.6	997.84				[M+H]+
0.69_453.37	0.69	453.3687				[M+H]+
3.12_793.63	3.12	793.6272				[M+H]+
3.29_458.42	3.29	458.4202				[M+H]+
9.17_930.72	9.17	930.7176				[M+H]+
0.81_381.13	0.81	381.1324				[M+H]+
3.85_308.05	3.85	308.0456				[M+H]+
1.31_486.36	1.31	486.3558				[M+H]+
3.86_559.22	3.86	559.2191				[M+H]+
0.56_267.18	0.56	267.1781				[M+H]+
0.71_263.08	0.71	263.0826				[M+H]+
0.94_337.24	0.94	337.2354				[M+H]+
0.83_288.26	0.83	288.259				[M+H]+
3.28_471.11	3.28	471.1069				[M+H]+
0.99_141.96	0.99	141.9592				[M+H]+
5.63_1197.81	5.63	1197.8069				[M+H]+
9.17_929.70	9.17	929.6986				[M+H]+
0.65_244.22	0.65	244.2226				[M+H]+
3.28_473.10	3.28	473.1045				[M+H]+
1.32_487.36	1.32	487.3579				[M+H]+
3.28_409.19	3.28	409.1856				[M+H]+
0.55_391.30	0.55	391.2957				[M+H]+
1.32_500.37	1.32	500.3711				[M+H]+
0.76_195.12	0.76	195.1224				[M+H]+
2.04_512.41	2.04	512.4115				[M+H]+
3.45_554.22	3.45	554.2246				[M+H]+
9.14_929.72	9.14	929.7183				[M+H]+
1.84_403.36	1.84	403.364				[M+H]+
0.62_195.12	0.62	195.1222				[M+H]+
6.19_751.78	6.19	751.7819				[M+H]+
1.55_195.12	1.55	195.1241				[M+H]+
8.48_280.17	8.48	280.1658				[M+H]+
3.85_338.50	3.85	338.5032				[M+H]+
7.71_680.58_7.71_685.54	7.71	680.5825				[M+NH4]+_[M+Na]+
1.13_195.12	1.13	195.1243				[M+H]+
3.55_458.35_3.55_463.30	3.55	458.3486				[M+NH4]+_[M+Na]+
0.66_228.23	0.66	228.2272				[M+H]+
7.97_131.16	7.97	131.1648				[M+H]+
11.52_132.14	11.52	132.1413				[M+H]+
3.14_715.61	3.14	715.606				[M+H]+
8.83_225.21	8.83	225.2091				[M+H]+
9.28_479.39	9.28	479.3914				[M+H]+
4.14_963.71	4.14	963.7122				[M+H]+
9.35_280.17	9.35	280.1665				[M+H]+
8.77_302.15	8.77	302.1489				[M+H]+
6.54_392.29	6.54	392.2912				[M+H]+
12.24_1093.99	12.24	1093.9871				[M+H]+
1.31_443.29	1.31	443.2868				[M+H]+
0.57_324.21	0.57	324.208				[M+H]+
4.86_516.43_4.86_521.38	4.86	516.4268				[M+NH4]+_[M+Na]+
1.51_478.32	1.51	478.3233				[M+H]+
5.53_391.28	5.53	391.2837				[M+H]+
6.18_766.84	6.18	766.8403				[M+H]+
1.31_399.42	1.31	399.4221				[M+H]+
0.57_237.11_0.57_259.09	0.57	237.1067				[M+H]+_[M+Na]+
6.26_665.46	6.26	665.4572				[M+H]+
7.26_492.41	7.26	492.4083				[M+H]+
0.57_473.20_0.57_495.18	0.57	473.199				[M+H]+_[M+Na]+
1.32_299.16	1.32	299.1622				[M+H]+
1.33_400.26	1.33	400.2553				[M+H]+
1.31_819.48	1.31	819.4769				[M+H]+
0.81_149.06	0.81	149.0574				[M+H]+
1.32_472.34	1.32	472.3392				[M+H]+
4.12_489.40	4.12	489.3983				[M+H]+
6.18_663.67	6.18	663.6706				[M+H]+
0.57_338.22	0.57	338.2234				[M+H]+
4.12_493.35	4.12	493.3528				[M+H]+
1.37_486.54	1.37	486.5403				[M+H]+
0.57_295.16	0.57	295.1575				[M+H]+
4.86_537.36	4.86	537.3556				[M+H]+
METABOLITES_END
#END