#METABOLOMICS WORKBENCH efahy_20180114_111150 DATATRACK_ID:1297 STUDY_ID:ST000915 ANALYSIS_ID:AN001486 PROJECT_ID:PR000633
VERSION             	1
CREATED_ON             	January 14, 2018, 11:41 am
#PROJECT
PR:PROJECT_TITLE                 	Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
PR:PROJECT_TYPE                  	Lipidomics Study
PR:PROJECT_SUMMARY               	The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis,
PR:PROJECT_SUMMARY               	nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely
PR:PROJECT_SUMMARY               	diagnosis of these different stages, particularly NASH, is important for both
PR:PROJECT_SUMMARY               	potential reversibility and limitation of complications. Liver biopsy remains
PR:PROJECT_SUMMARY               	the clinical standard for definitive diagnosis. Diagnostic tools minimizing the
PR:PROJECT_SUMMARY               	need for invasive procedures or that add information to histologic data are
PR:PROJECT_SUMMARY               	important in novel management strategies for the growing epidemic of NAFLD. We
PR:PROJECT_SUMMARY               	describe an 'omics' approach to detecting a reproducible signature of lipid
PR:PROJECT_SUMMARY               	metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a
PR:PROJECT_SUMMARY               	double-blinded study of patients with different stages of NAFLD that involves
PR:PROJECT_SUMMARY               	profiling liver biopsies, plasma, and urine samples. Using linear discriminant
PR:PROJECT_SUMMARY               	analysis, a panel of 20 plasma metabolites that includes glycerophospholipids,
PR:PROJECT_SUMMARY               	sphingolipids, sterols, and various aqueous small molecular weight components
PR:PROJECT_SUMMARY               	involved in cellular metabolic pathways, can be used to differentiate between
PR:PROJECT_SUMMARY               	NASH and steatosis. This identification of differential biomolecular signatures
PR:PROJECT_SUMMARY               	has the potential to improve clinical diagnosis and facilitate therapeutic
PR:PROJECT_SUMMARY               	intervention of NAFLD.
PR:INSTITUTE                     	University of California, San Diego
PR:DEPARTMENT                    	Bioengineering
PR:LAST_NAME                     	Fahy
PR:FIRST_NAME                    	Eoin
PR:ADDRESS                       	9500 Gilman, La Jolla, CA, 92093, USA
PR:EMAIL                         	efahy@ucsd.edu
PR:PHONE                         	858-534-4076
PR:FUNDING_SOURCE                	NIGMS Grant GM U54069338
PR:PUBLICATIONS                  	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
PR:CONTRIBUTORS                  	LIPID MAPS Consortium
#STUDY
ST:STUDY_TITLE                   	Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part
ST:STUDY_TITLE                   	1:Liver
ST:STUDY_TYPE                    	Lipidomics Study
ST:STUDY_SUMMARY                 	The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis,
ST:STUDY_SUMMARY                 	nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely
ST:STUDY_SUMMARY                 	diagnosis of these different stages, particularly NASH, is important for both
ST:STUDY_SUMMARY                 	potential reversibility and limitation of complications. Liver biopsy remains
ST:STUDY_SUMMARY                 	the clinical standard for definitive diagnosis. Diagnostic tools minimizing the
ST:STUDY_SUMMARY                 	need for invasive procedures or that add information to histologic data are
ST:STUDY_SUMMARY                 	important in novel management strategies for the growing epidemic of NAFLD. We
ST:STUDY_SUMMARY                 	describe an 'omics' approach to detecting a reproducible signature of lipid
ST:STUDY_SUMMARY                 	metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a
ST:STUDY_SUMMARY                 	double-blinded study of patients with different stages of NAFLD that involves
ST:STUDY_SUMMARY                 	profiling liver biopsies, plasma, and urine samples. Using linear discriminant
ST:STUDY_SUMMARY                 	analysis, a panel of 20 plasma metabolites that includes glycerophospholipids,
ST:STUDY_SUMMARY                 	sphingolipids, sterols, and various aqueous small molecular weight components
ST:STUDY_SUMMARY                 	involved in cellular metabolic pathways, can be used to differentiate between
ST:STUDY_SUMMARY                 	NASH and steatosis. This identification of differential biomolecular signatures
ST:STUDY_SUMMARY                 	has the potential to improve clinical diagnosis and facilitate therapeutic
ST:STUDY_SUMMARY                 	intervention of NAFLD.
ST:INSTITUTE                     	University of California, San Diego
ST:DEPARTMENT                    	Bioengineering
ST:LAST_NAME                     	Fahy
ST:FIRST_NAME                    	Eoin
ST:ADDRESS                       	9500 Gilman, La Jolla, CA, 92093, USA
ST:EMAIL                         	efahy@ucsd.edu
ST:PHONE                         	858-534-4076
ST:PUBLICATIONS                  	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
#SUBJECT
SU:SUBJECT_TYPE                  	Human clinical study
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:AGE_OR_AGE_RANGE              	23-83
SU:GENDER                        	Male and Female
SU:HUMAN_ETHNICITY               	Black/White
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	-	NASH005	Diagnosis:Cirrhosis	GENDER=M; BMI=31; ETHNICITY=White; AGE=45; AST=55; ALT=20; ALKP=171; TBIL=8.2; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH007	Diagnosis:Cirrhosis	GENDER=F; BMI=40.3; ETHNICITY=White; AGE=64; AST=39; ALT=20; ALKP=102; TBIL=3; GLUCOSE=92
SUBJECT_SAMPLE_FACTORS           	-	NASH009	Diagnosis:Cirrhosis	GENDER=M; BMI=40; ETHNICITY=White; AGE=49; AST=162; ALT=66; ALKP=123; TBIL=10.5; GLUCOSE=119
SUBJECT_SAMPLE_FACTORS           	-	NASH013	Diagnosis:Cirrhosis	GENDER=M; BMI=35; ETHNICITY=White; AGE=59; AST=44; ALT=32; ALKP=95; TBIL=2.9; GLUCOSE=100
SUBJECT_SAMPLE_FACTORS           	-	NASH016	Diagnosis:Cirrhosis	GENDER=M; BMI=26; ETHNICITY=Asian; AGE=66; AST=223; ALT=100; ALKP=149; TBIL=5.2; GLUCOSE=117
SUBJECT_SAMPLE_FACTORS           	-	NASH022	Diagnosis:Cirrhosis	GENDER=M; BMI=27; ETHNICITY=White; AGE=63; AST=55; ALT=34; ALKP=91; TBIL=6.5; GLUCOSE=220
SUBJECT_SAMPLE_FACTORS           	-	NASH026	Diagnosis:Cirrhosis	GENDER=M; BMI=26.5; ETHNICITY=White; AGE=57; AST=18; ALT=38; ALKP=37; TBIL=4.2; GLUCOSE=122
SUBJECT_SAMPLE_FACTORS           	-	NASH027	Diagnosis:Cirrhosis	GENDER=M; BMI=31; ETHNICITY=-; AGE=58; AST=30; ALT=36; ALKP=105; TBIL=3.4; GLUCOSE=131
SUBJECT_SAMPLE_FACTORS           	-	NASH028	Diagnosis:Cirrhosis	GENDER=F; BMI=31; ETHNICITY=White; AGE=48; AST=46; ALT=47; ALKP=192; TBIL=2.4; GLUCOSE=173
SUBJECT_SAMPLE_FACTORS           	-	NASH029	Diagnosis:Cirrhosis	GENDER=F; BMI=21.5; ETHNICITY=White; AGE=49; AST=92; ALT=54; ALKP=277; TBIL=41.7; GLUCOSE=113
SUBJECT_SAMPLE_FACTORS           	-	NASH040	Diagnosis:Cirrhosis	GENDER=F; BMI=44; ETHNICITY=White; AGE=63; AST=36; ALT=26; ALKP=62; TBIL=1.7; GLUCOSE=65
SUBJECT_SAMPLE_FACTORS           	-	NASH047	Diagnosis:Cirrhosis	GENDER=M; BMI=-; ETHNICITY=White; AGE=60; AST=51; ALT=24; ALKP=57; TBIL=11.3; GLUCOSE=241
SUBJECT_SAMPLE_FACTORS           	-	NASH048	Diagnosis:Cirrhosis	GENDER=M; BMI=26; ETHNICITY=White; AGE=66; AST=44; ALT=23; ALKP=100; TBIL=4.5; GLUCOSE=79
SUBJECT_SAMPLE_FACTORS           	-	NASH049	Diagnosis:Cirrhosis	GENDER=M; BMI=35; ETHNICITY=White; AGE=71; AST=42; ALT=21; ALKP=82; TBIL=3.8; GLUCOSE=145
SUBJECT_SAMPLE_FACTORS           	-	NASH052	Diagnosis:Cirrhosis	GENDER=M; BMI=-; ETHNICITY=-; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH055	Diagnosis:Cirrhosis	GENDER=M; BMI=36.8; ETHNICITY=White; AGE=67; AST=35; ALT=24; ALKP=91; TBIL=0.9; GLUCOSE=135
SUBJECT_SAMPLE_FACTORS           	-	NASH064	Diagnosis:Cirrhosis	GENDER=F; BMI=27.9; ETHNICITY=White; AGE=67; AST=67; ALT=31; ALKP=113; TBIL=5.5; GLUCOSE=82
SUBJECT_SAMPLE_FACTORS           	-	NASH065	Diagnosis:Cirrhosis	GENDER=M; BMI=41.9; ETHNICITY=White; AGE=36; AST=32; ALT=17; ALKP=44; TBIL=0.2; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH068	Diagnosis:Cirrhosis	GENDER=M; BMI=23; ETHNICITY=White; AGE=55; AST=46; ALT=21; ALKP=67; TBIL=1.4; GLUCOSE=96
SUBJECT_SAMPLE_FACTORS           	-	NASH069	Diagnosis:Cirrhosis	GENDER=M; BMI=29.9; ETHNICITY=White; AGE=56; AST=74; ALT=57; ALKP=258; TBIL=3.1; GLUCOSE=84
SUBJECT_SAMPLE_FACTORS           	-	NASH010	Diagnosis:NASH	GENDER=F; BMI=43.3; ETHNICITY=White; AGE=46; AST=33; ALT=35; ALKP=71; TBIL=0.4; GLUCOSE=175
SUBJECT_SAMPLE_FACTORS           	-	NASH012	Diagnosis:NASH	GENDER=F; BMI=49; ETHNICITY=White; AGE=38; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH015	Diagnosis:NASH	GENDER=M; BMI=44; ETHNICITY=White; AGE=58; AST=27; ALT=39; ALKP=41; TBIL=0.2; GLUCOSE=125
SUBJECT_SAMPLE_FACTORS           	-	NASH018	Diagnosis:NASH	GENDER=F; BMI=51; ETHNICITY=Black; AGE=44; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=96
SUBJECT_SAMPLE_FACTORS           	-	NASH019	Diagnosis:NASH	GENDER=M; BMI=34; ETHNICITY=White; AGE=73; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=107
SUBJECT_SAMPLE_FACTORS           	-	NASH021	Diagnosis:NASH	GENDER=M; BMI=28; ETHNICITY=White; AGE=59; AST=30; ALT=39; ALKP=63; TBIL=0.9; GLUCOSE=185
SUBJECT_SAMPLE_FACTORS           	-	NASH030	Diagnosis:NASH	GENDER=F; BMI=41.6; ETHNICITY=White; AGE=28; AST=24; ALT=24; ALKP=77; TBIL=0.1; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH031	Diagnosis:NASH	GENDER=F; BMI=41.5; ETHNICITY=White; AGE=46; AST=17; ALT=23; ALKP=94; TBIL=0.2; GLUCOSE=135
SUBJECT_SAMPLE_FACTORS           	-	NASH035	Diagnosis:NASH	GENDER=M; BMI=74.7; ETHNICITY=White; AGE=45; AST=23; ALT=30; ALKP=72; TBIL=0.3; GLUCOSE=84
SUBJECT_SAMPLE_FACTORS           	-	NASH037	Diagnosis:NASH	GENDER=M; BMI=44; ETHNICITY=White; AGE=53; AST=52; ALT=83; ALKP=98; TBIL=0.3; GLUCOSE=165
SUBJECT_SAMPLE_FACTORS           	-	NASH038	Diagnosis:NASH	GENDER=M; BMI=45; ETHNICITY=White; AGE=65; AST=36; ALT=37; ALKP=67; TBIL=0.3; GLUCOSE=97
SUBJECT_SAMPLE_FACTORS           	-	NASH039	Diagnosis:NASH	GENDER=M; BMI=48; ETHNICITY=White; AGE=35; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH044	Diagnosis:NASH	GENDER=M; BMI=61; ETHNICITY=Black; AGE=41; AST=22; ALT=24; ALKP=57; TBIL=0.6; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH057	Diagnosis:NASH	GENDER=F; BMI=47.3; ETHNICITY=White; AGE=53; AST=25; ALT=18; ALKP=71; TBIL=0.6; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH072	Diagnosis:NASH	GENDER=M; BMI=77.3; ETHNICITY=White; AGE=50; AST=29; ALT=12; ALKP=85; TBIL=0.8; GLUCOSE=207
SUBJECT_SAMPLE_FACTORS           	-	NASH074	Diagnosis:NASH	GENDER=F; BMI=31; ETHNICITY=White; AGE=52; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=169
SUBJECT_SAMPLE_FACTORS           	-	NASH084	Diagnosis:NASH	GENDER=F; BMI=63; ETHNICITY=White; AGE=48; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=120
SUBJECT_SAMPLE_FACTORS           	-	NASH087	Diagnosis:NASH	GENDER=F; BMI=52; ETHNICITY=Black; AGE=58; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=175
SUBJECT_SAMPLE_FACTORS           	-	NASH088	Diagnosis:NASH	GENDER=F; BMI=40; ETHNICITY=Black; AGE=27; AST=15; ALT=19; ALKP=134; TBIL=0.4; GLUCOSE=133
SUBJECT_SAMPLE_FACTORS           	-	NASH090	Diagnosis:NASH	GENDER=F; BMI=35; ETHNICITY=White; AGE=32; AST=15; ALT=20; ALKP=69; TBIL=-; GLUCOSE=110
SUBJECT_SAMPLE_FACTORS           	-	NASH003	Diagnosis:Normal	GENDER=F; BMI=47.3; ETHNICITY=White; AGE=46; AST=36; ALT=54; ALKP=76; TBIL=-; GLUCOSE=90
SUBJECT_SAMPLE_FACTORS           	-	NASH004	Diagnosis:Normal	GENDER=M; BMI=-; ETHNICITY=White; AGE=23; AST=106; ALT=95; ALKP=-; TBIL=0.7; GLUCOSE=97
SUBJECT_SAMPLE_FACTORS           	-	NASH006	Diagnosis:Normal	GENDER=F; BMI=-; ETHNICITY=White; AGE=40; AST=68; ALT=72; ALKP=74; TBIL=0.5; GLUCOSE=93
SUBJECT_SAMPLE_FACTORS           	-	NASH011	Diagnosis:Normal	GENDER=M; BMI=29.1; ETHNICITY=White; AGE=54; AST=40; ALT=22; ALKP=42; TBIL=0.9; GLUCOSE=101
SUBJECT_SAMPLE_FACTORS           	-	NASH014	Diagnosis:Normal	GENDER=F; BMI=36; ETHNICITY=Black; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=139
SUBJECT_SAMPLE_FACTORS           	-	NASH017	Diagnosis:Normal	GENDER=M; BMI=45; ETHNICITY=White; AGE=59; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=101
SUBJECT_SAMPLE_FACTORS           	-	NASH020	Diagnosis:Normal	GENDER=M; BMI=29; ETHNICITY=White; AGE=33; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH024	Diagnosis:Normal	GENDER=F; BMI=35; ETHNICITY=Black; AGE=43; AST=20; ALT=13; ALKP=71; TBIL=0.9; GLUCOSE=95
SUBJECT_SAMPLE_FACTORS           	-	NASH034	Diagnosis:Normal	GENDER=F; BMI=51.5; ETHNICITY=White; AGE=49; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=172
SUBJECT_SAMPLE_FACTORS           	-	NASH036	Diagnosis:Normal	GENDER=F; BMI=39; ETHNICITY=Black; AGE=45; AST=21; ALT=23; ALKP=111; TBIL=0.2; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH041	Diagnosis:Normal	GENDER=F; BMI=63; ETHNICITY=Black; AGE=27; AST=21; ALT=19; ALKP=86; TBIL=0.3; GLUCOSE=106
SUBJECT_SAMPLE_FACTORS           	-	NASH042	Diagnosis:Normal	GENDER=F; BMI=42; ETHNICITY=White; AGE=58; AST=18; ALT=16; ALKP=98; TBIL=0.4; GLUCOSE=105
SUBJECT_SAMPLE_FACTORS           	-	NASH043	Diagnosis:Normal	GENDER=F; BMI=52; ETHNICITY=White; AGE=39; AST=13; ALT=12; ALKP=76; TBIL=0.3; GLUCOSE=104
SUBJECT_SAMPLE_FACTORS           	-	NASH045	Diagnosis:Normal	GENDER=F; BMI=48; ETHNICITY=Black; AGE=43; AST=13; ALT=15; ALKP=90; TBIL=0.3; GLUCOSE=104
SUBJECT_SAMPLE_FACTORS           	-	NASH046	Diagnosis:Normal	GENDER=F; BMI=40; ETHNICITY=White; AGE=36; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=104
SUBJECT_SAMPLE_FACTORS           	-	NASH050	Diagnosis:Normal	GENDER=F; BMI=52.5; ETHNICITY=Black; AGE=38; AST=15; ALT=12; ALKP=75; TBIL=0.1; GLUCOSE=96
SUBJECT_SAMPLE_FACTORS           	-	NASH051	Diagnosis:Normal	GENDER=F; BMI=50.6; ETHNICITY=White; AGE=29; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH053	Diagnosis:Normal	GENDER=F; BMI=25.1; ETHNICITY=White; AGE=56; AST=26; ALT=14; ALKP=180; TBIL=0.8; GLUCOSE=140
SUBJECT_SAMPLE_FACTORS           	-	NASH054	Diagnosis:Normal	GENDER=F; BMI=30.8; ETHNICITY=White; AGE=83; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=90
SUBJECT_SAMPLE_FACTORS           	-	NASH060	Diagnosis:Normal	GENDER=F; BMI=39.7; ETHNICITY=Black; AGE=36; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=115
SUBJECT_SAMPLE_FACTORS           	-	NASH066	Diagnosis:Normal	GENDER=F; BMI=40.3; ETHNICITY=Black; AGE=52; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=95
SUBJECT_SAMPLE_FACTORS           	-	NASH067	Diagnosis:Normal	GENDER=F; BMI=39.2; ETHNICITY=Black; AGE=33; AST=17; ALT=14; ALKP=73; TBIL=0.2; GLUCOSE=87
SUBJECT_SAMPLE_FACTORS           	-	NASH070	Diagnosis:Normal	GENDER=F; BMI=25.7; ETHNICITY=White; AGE=53; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH077	Diagnosis:Normal	GENDER=M; BMI=33; ETHNICITY=White; AGE=67; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=193
SUBJECT_SAMPLE_FACTORS           	-	NASH078	Diagnosis:Normal	GENDER=F; BMI=45; ETHNICITY=Black; AGE=40; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=101
SUBJECT_SAMPLE_FACTORS           	-	NASH080	Diagnosis:Normal	GENDER=F; BMI=50; ETHNICITY=White; AGE=57; AST=26; ALT=28; ALKP=54; TBIL=0.3; GLUCOSE=155
SUBJECT_SAMPLE_FACTORS           	-	NASH082	Diagnosis:Normal	GENDER=M; BMI=34; ETHNICITY=White; AGE=73; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH085	Diagnosis:Normal	GENDER=F; BMI=32; ETHNICITY=White; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH086	Diagnosis:Normal	GENDER=F; BMI=38; ETHNICITY=White; AGE=35; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH089	Diagnosis:Normal	GENDER=F; BMI=52; ETHNICITY=White; AGE=49; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH091	Diagnosis:Normal	GENDER=F; BMI=29; ETHNICITY=White; AGE=68; AST=14; ALT=18; ALKP=66; TBIL=0.4; GLUCOSE=107
SUBJECT_SAMPLE_FACTORS           	-	NASH001	Diagnosis:Steatosis	GENDER=M; BMI=52.3; ETHNICITY=Black; AGE=37; AST=16; ALT=19; ALKP=58; TBIL=0.4; GLUCOSE=236
SUBJECT_SAMPLE_FACTORS           	-	NASH002	Diagnosis:Steatosis	GENDER=F; BMI=34.9; ETHNICITY=White; AGE=57; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH023	Diagnosis:Steatosis	GENDER=M; BMI=34; ETHNICITY=White; AGE=56; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=97
SUBJECT_SAMPLE_FACTORS           	-	NASH032	Diagnosis:Steatosis	GENDER=F; BMI=45; ETHNICITY=White; AGE=58; AST=27; ALT=20; ALKP=83; TBIL=0.9; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH033	Diagnosis:Steatosis	GENDER=F; BMI=40; ETHNICITY=White; AGE=58; AST=38; ALT=29; ALKP=102; TBIL=0.5; GLUCOSE=109
SUBJECT_SAMPLE_FACTORS           	-	NASH056	Diagnosis:Steatosis	GENDER=F; BMI=45.1; ETHNICITY=White; AGE=51; AST=38; ALT=28; ALKP=45; TBIL=0.5; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH058	Diagnosis:Steatosis	GENDER=M; BMI=42.7; ETHNICITY=Black; AGE=53; AST=28; ALT=34; ALKP=72; TBIL=0.6; GLUCOSE=174
SUBJECT_SAMPLE_FACTORS           	-	NASH059	Diagnosis:Steatosis	GENDER=F; BMI=49.8; ETHNICITY=White; AGE=45; AST=16; ALT=16; ALKP=84; TBIL=0.3; GLUCOSE=92
SUBJECT_SAMPLE_FACTORS           	-	NASH061	Diagnosis:Steatosis	GENDER=F; BMI=56.7; ETHNICITY=White; AGE=29; AST=64; ALT=50; ALKP=68; TBIL=0.8; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH062	Diagnosis:Steatosis	GENDER=F; BMI=56.6; ETHNICITY=White; AGE=51; AST=15; ALT=16; ALKP=58; TBIL=0.5; GLUCOSE=90
SUBJECT_SAMPLE_FACTORS           	-	NASH071	Diagnosis:Steatosis	GENDER=F; BMI=40; ETHNICITY=White; AGE=33; AST=15; ALT=12; ALKP=59; TBIL=0.4; GLUCOSE=85
SUBJECT_SAMPLE_FACTORS           	-	NASH073	Diagnosis:Steatosis	GENDER=F; BMI=80.2; ETHNICITY=Black; AGE=34; AST=11; ALT=11; ALKP=90; TBIL=0.4; GLUCOSE=163
SUBJECT_SAMPLE_FACTORS           	-	NASH075	Diagnosis:Steatosis	GENDER=M; BMI=33; ETHNICITY=White; AGE=67; AST=22; ALT=34; ALKP=96; TBIL=0.5; GLUCOSE=191
SUBJECT_SAMPLE_FACTORS           	-	NASH076	Diagnosis:Steatosis	GENDER=F; BMI=50; ETHNICITY=White; AGE=51; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=92
SUBJECT_SAMPLE_FACTORS           	-	NASH079	Diagnosis:Steatosis	GENDER=F; BMI=43; ETHNICITY=White; AGE=37; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=85
SUBJECT_SAMPLE_FACTORS           	-	NASH081	Diagnosis:Steatosis	GENDER=F; BMI=46; ETHNICITY=White; AGE=65; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=119
SUBJECT_SAMPLE_FACTORS           	-	NASH083	Diagnosis:Steatosis	GENDER=M; BMI=39; ETHNICITY=White; AGE=41; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=106
#COLLECTION
CO:COLLECTION_SUMMARY            	Human samples were collected according to a protocol approved by Vanderbilt
CO:COLLECTION_SUMMARY            	University Medical Center's Internal Review Board (#120829) and under informed
CO:COLLECTION_SUMMARY            	written patients' consent prior to inclusion in this study. Sample sizes were
CO:COLLECTION_SUMMARY            	selected to minimize the invasive procedures. Plasma samples were obtained from
CO:COLLECTION_SUMMARY            	patients' blood collected during standard of care surgical procedures. Urine
CO:COLLECTION_SUMMARY            	samples were collected from patients' Foley catheters placed for standard of
CO:COLLECTION_SUMMARY            	care procedure. Liver samples were obtained from the excess tissue collected as
CO:COLLECTION_SUMMARY            	part of the standard of care liver biopsies performed at the time of surgery
CO:COLLECTION_SUMMARY            	that would otherwise be discarded. Subsequently, studies at University of
CO:COLLECTION_SUMMARY            	California, San Diego were conducted under further auspices of University of
CO:COLLECTION_SUMMARY            	California, San Diego Internal Review Board #121220.
CO:SAMPLE_TYPE                   	Liver
#TREATMENT
TR:TREATMENT_SUMMARY             	-
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Liver sample extraction. Approximately 10 mg of frozen liver was homogenized in
SP:SAMPLEPREP_SUMMARY            	500 µl of cold (-20°C) 70% CH3OH using a tight-fit glass homogenizer
SP:SAMPLEPREP_SUMMARY            	(Kimble/Kontes Glass Co., Vineland, NJ) for about 1 min on ice in the presence
SP:SAMPLEPREP_SUMMARY            	of 4 µl of internal standard mix. The suspension was vortexed for 10 s and left
SP:SAMPLEPREP_SUMMARY            	in an ice bath for 30 min. After mixing by vortex at 4°C for 1 min and
SP:SAMPLEPREP_SUMMARY            	centrifugation (4°C, 18,000 g, 10 min), the supernatant was collected and the
SP:SAMPLEPREP_SUMMARY            	solvent was evaporated. The residue was dissolved in 200 µl of resuspension
SP:SAMPLEPREP_SUMMARY            	solvent, vortexed to mix (1 min at 4°C), and centrifuged (4°C, 18,000 g, 10
SP:SAMPLEPREP_SUMMARY            	min) to remove any insoluble material. GPLs: GPLs from liver samples were
SP:SAMPLEPREP_SUMMARY            	extracted and analyzed by MS essentially as described in (20, 21). Extraction
SP:SAMPLEPREP_SUMMARY            	and analysis of plasma samples was according to previously published procedures
SP:SAMPLEPREP_SUMMARY            	(22). Cardiolipin, coenzyme Q, and dolichol: Lipid extractions were performed
SP:SAMPLEPREP_SUMMARY            	based on the Bligh and Dyer method with minor modifications (23-25). FAs and
SP:SAMPLEPREP_SUMMARY            	eicosanoids: FFAs were extracted essentially as previously described after
SP:SAMPLEPREP_SUMMARY            	supplementation with deuterated internal standards (Cayman Chemicals) (26, 27).
SP:SAMPLEPREP_SUMMARY            	Eicosanoids were isolated via solid phase extraction, utilizing 25 deuterated
SP:SAMPLEPREP_SUMMARY            	internal standards (28, 29). Sterols and oxysterols: Sterols and oxysterols were
SP:SAMPLEPREP_SUMMARY            	extracted using previously described methods (30). Neutral lipids: Cholesteryl
SP:SAMPLEPREP_SUMMARY            	esters (CEs), TAGs, and DAGs were extracted from weighed liver tissue (0.5-1 mg)
SP:SAMPLEPREP_SUMMARY            	suspended in 0.5 ml PBS that had been homogenized by sonication. Extractions of
SP:SAMPLEPREP_SUMMARY            	plasma (0.05 ml diluted to 0.1 ml with PBS), urine (1 ml), and tissue sonicates
SP:SAMPLEPREP_SUMMARY            	were carried out using 1 ml hexane:methyl t-butyl ether (1:1, v/v), essentially
SP:SAMPLEPREP_SUMMARY            	as previously described (31). Sphingolipids: Sphingolipids from liver, plasma,
SP:SAMPLEPREP_SUMMARY            	and urine were extracted following previously published procedures (32, 33),
SP:SAMPLEPREP_SUMMARY            	with the exception that methylene chloride was substituted for chloroform for
SP:SAMPLEPREP_SUMMARY            	the single-phase extraction of sphingoid bases  20. Ivanova P. T., Milne S. B.,
SP:SAMPLEPREP_SUMMARY            	Byrne M. O., Xiang Y., Brown H. A. 2007. Glycerophospholipid identification and
SP:SAMPLEPREP_SUMMARY            	quantitation by electrospray ionization mass spectrometry. Methods Enzymol. 432:
SP:SAMPLEPREP_SUMMARY            	21-57.  21. Myers D. S., Ivanova P. T., Milne S. B., Brown H. A. 2011.
SP:SAMPLEPREP_SUMMARY            	Quantitative analysis of glycerophospholipids by LC-MS: acquisition, data
SP:SAMPLEPREP_SUMMARY            	handling, and interpretation. Biochim. Biophys. Acta. 1811: 748-757.  22.
SP:SAMPLEPREP_SUMMARY            	Quehenberger O., Armando A. M., Brown H. A., Milne S. B., Myers D. S., Merrill
SP:SAMPLEPREP_SUMMARY            	A. H., Jr, Bandyopadhyay S., Jones K. N., Kelly S., Shaner R. L., et al. 2010.
SP:SAMPLEPREP_SUMMARY            	Lipidomics reveals a remarkable diversity of lipids in human plasma. J. Lipid
SP:SAMPLEPREP_SUMMARY            	Res. 51: 3299-3305.  23. Guan Z., Li S., Smith D., Shaw W., Raetz C. 2007.
SP:SAMPLEPREP_SUMMARY            	Identification of N-acylphosphatidylserine molecules in eukaryotic cells.
SP:SAMPLEPREP_SUMMARY            	Biochemistry. 46: 14500-14513.  24. Tan B. K., Bogdanov M., Zhao J., Dowhan W.,
SP:SAMPLEPREP_SUMMARY            	Raetz C. R., Guan Z. 2012. Discovery of cardiolipin synthase utilizing
SP:SAMPLEPREP_SUMMARY            	phosphatidylethanolamine and phosphatidylglycerol as substrates. Proc. Natl.
SP:SAMPLEPREP_SUMMARY            	Acad. Sci. USA. 109: 16504-16509.  25. Wen R., Lam B., Guan Z. 2013. Aberrant
SP:SAMPLEPREP_SUMMARY            	dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired
SP:SAMPLEPREP_SUMMARY            	dolichol biosynthesis. J. Lipid Res. 54: 3516-3522.  26. Quehenberger O.,
SP:SAMPLEPREP_SUMMARY            	Armando A., Dumlao D., Stephens D. L., Dennis E. A. 2008. Lipidomics analysis of
SP:SAMPLEPREP_SUMMARY            	essential fatty acids in macrophages. Prostaglandins Leukot. Essent. Fatty
SP:SAMPLEPREP_SUMMARY            	Acids. 79: 123-129.  27. Quehenberger O., Armando A. M., Dennis E. A. 2011. High
SP:SAMPLEPREP_SUMMARY            	sensitivity quantitative lipidomics analysis of fatty acids in biological
SP:SAMPLEPREP_SUMMARY            	samples by gas chromatography-mass spectrometry. Biochim. Biophys. Acta. 1811:
SP:SAMPLEPREP_SUMMARY            	648-656.  28. Deems R., Buczynski M. W., Bowers-Gentry R., Harkewicz R., Dennis
SP:SAMPLEPREP_SUMMARY            	E. A. 2007. Detection and quantitation of eicosanoids via high performance
SP:SAMPLEPREP_SUMMARY            	liquid chromatography-electrospray ionization-mass spectrometry. Methods
SP:SAMPLEPREP_SUMMARY            	Enzymol. 432: 59-82.  29. Dumlao D. S., Buczynski M. W., Norris P. C., Harkewicz
SP:SAMPLEPREP_SUMMARY            	R., Dennis E. A. 2011. High-throughput lipidomic analysis of fatty acid derived
SP:SAMPLEPREP_SUMMARY            	eicosanoids and N-acylethanolamines. Biochim. Biophys. Acta. 1811: 724-736.  30.
SP:SAMPLEPREP_SUMMARY            	McDonald J. G., Smith D. D., Stiles A. R., Russell D. W. 2012. A comprehensive
SP:SAMPLEPREP_SUMMARY            	method for extraction and quantitative analysis of sterols and secosteroids from
SP:SAMPLEPREP_SUMMARY            	human plasma. J. Lipid Res. 53: 1399-1409.  31. Hutchins P. M., Barkley R. M.,
SP:SAMPLEPREP_SUMMARY            	Murphy R. C. 2008. Separation of cellular nonpolar neutral lipids by
SP:SAMPLEPREP_SUMMARY            	normal-phase chromatography and analysis by electrospray ionization mass
SP:SAMPLEPREP_SUMMARY            	spectrometry. J. Lipid Res. 49: 804-813. 32. Shaner R. L., Allegood J. C., Park
SP:SAMPLEPREP_SUMMARY            	H., Wang E., Kelly S., Haynes C. A., Sullards M. C., Merrill A. H., Jr 2009.
SP:SAMPLEPREP_SUMMARY            	Quantitative analysis of sphingolipids for lipidomics using triple quadrupole
SP:SAMPLEPREP_SUMMARY            	and quadrupole linear ion trap mass spectrometers. J. Lipid Res. 50: 1692-1707.
SP:SAMPLEPREP_SUMMARY            	33. Sullards M. C., Liu Y., Chen Y., Merrill A. H., Jr 2011. Analysis of
SP:SAMPLEPREP_SUMMARY            	mammalian sphingolipids by liquid chromatography tandem mass spectrometry
SP:SAMPLEPREP_SUMMARY            	(LC-MS/MS) and tissue imaging mass spectrometry (TIMS). Biochim. Biophys. Acta.
SP:SAMPLEPREP_SUMMARY            	1811: 838-853.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Sterols and oxysterols were measured using methods previously described (30).
CH:CHROMATOGRAPHY_SUMMARY        	Plasma total cholesterol was measured using a Vitros 250 chemistry system
CH:CHROMATOGRAPHY_SUMMARY        	(Ortho-Clinical Diagnostics, Rochester, NY). Plasma free cholesterol and liver
CH:CHROMATOGRAPHY_SUMMARY        	free and total cholesterol were measured using methods adapted from (30). 30.
CH:CHROMATOGRAPHY_SUMMARY        	McDonald J. G., Smith D. D., Stiles A. R., Russell D. W. 2012. A comprehensive
CH:CHROMATOGRAPHY_SUMMARY        	method for extraction and quantitative analysis of sterols and secosteroids from
CH:CHROMATOGRAPHY_SUMMARY        	human plasma. J. Lipid Res. 53: 1399-1409.
CH:INSTRUMENT_NAME               	Multiple
CH:COLUMN_NAME                   	Multiple
CH:CHROMATOGRAPHY_TYPE           	Core J
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:MS_COMMENTS                   	-
MS:INSTRUMENT_NAME               	-
MS:INSTRUMENT_TYPE               	-
MS:MS_TYPE                       	Other
MS:ION_MODE                      	UNSPECIFIED
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS         	nmol/mg
MS_METABOLITE_DATA_START
Samples	NASH001	NASH002	NASH003	NASH004	NASH005	NASH006	NASH007	NASH009	NASH010	NASH011	NASH012	NASH013	NASH014	NASH015	NASH016	NASH017	NASH018	NASH019	NASH020	NASH021	NASH022	NASH023	NASH024	NASH026	NASH027	NASH028	NASH029	NASH030	NASH031	NASH032	NASH033	NASH034	NASH035	NASH036	NASH037	NASH038	NASH039	NASH040	NASH041	NASH042	NASH043	NASH044	NASH045	NASH046	NASH047	NASH048	NASH049	NASH050	NASH051	NASH052	NASH053	NASH054	NASH055	NASH056	NASH057	NASH058	NASH059	NASH060	NASH061	NASH062	NASH064	NASH065	NASH066	NASH067	NASH068	NASH069	NASH070	NASH071	NASH072	NASH073	NASH074	NASH075	NASH076	NASH077	NASH078	NASH079	NASH080	NASH081	NASH082	NASH083	NASH084	NASH085	NASH086	NASH087	NASH088	NASH089	NASH090	NASH091
Factors	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Normal
7alpha,25-dihydroxycholesterol	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
7alpha,27-dihydroxy cholesterol	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	0.000251	ND	ND	ND	0.000490	0.000251	ND	0.000179	0.000287	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
7alpha,24S-dihydroxycholesterol	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
5alpha,6alpha-24S,25-diepoxy-cholesterol	0.001141	0.000383	0.000119	0.000136	0.000908	0.000088	0.000665	0.000401	0.000128	0.000640	0.000828	0.000527	0.000414	0.000201	0.000314	0.000502	0.000515	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
25-hydroxy Vitamin D3	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
25-hydroxy Vitamin D2	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
22R-hydroxy-cholesterol	0.000448	0.000952	0.000254	0.000699	0.000332	0.000581	0.000282	0.000142	0.000327	0.000510	0.000323	0.000224	0.000733	0.000249	0.000099	0.000236	0.000249	0.000596	0.000410	0.000373	0.000447	0.000124	0.000472	0.000186	0.000137	0.000062	0.000137	0.000199	0.000062	0.000025	0.000037	0.000012	0.000012	0.000062	0.000050	0.000050	0.000025	0.000075	0.000075	0.000137	0.000199	0.000174	0.000671	0.000249	0.000099	0.000186	0.000087	0.000298	0.000137	0.000162	0.000261	0.000634	0.000261	0.000112	0.000186	0.000162	0.000609	0.000472	0.000174	0.000298	0.000211	0.000037	0.000311	0.000721	0.000075	0.000149	0.000609	0.000336	0.000075	0.000186	0.000137	0.000211	0.000211	0.000249	0.000373	0.000186	0.000186	0.000186	0.000336	0.000199	0.000062	0.000522	0.000112	0.000311	0.000584	0.000497	0.000149	0.000124
25-hydroxy-cholesterol	0.000151	0.000128	0.000058	0.000091	0.000106	0.000039	0.000064	0.000128	0.000061	0.000072	0.000166	0.000058	0.000091	0.000106	0.000039	0.000064	0.000083	0.010526	0.000012	0.000075	0.000124	0.000273	0.000087	0.000062	0.000112	0.000087	0.000050	0.000087	0.000062	0.000025	0.000037	0.000012	0.000012	0.000062	0.000050	0.000050	0.000025	0.000087	0.000075	0.000037	0.000012	0.000025	0.000050	ND	0.000050	0.000037	0.000124	0.000037	ND	0.000037	0.000050	0.000037	ND	0.000037	0.000037	0.000062	0.000050	0.000037	0.000037	0.000050	0.000037	0.000075	ND	0.000037	0.000062	0.000025	0.000012	0.000050	0.000025	0.000050	0.000025	0.000062	0.000050	0.000062	0.000050	0.000062	0.000037	0.000050	0.000149	0.000037	0.000062	0.000050	0.000025	0.000075	0.000025	0.000025	0.000050	0.000050
24S-hydroxy-cholesterol	0.000562	0.001473	0.000243	0.000339	0.000900	0.000117	0.000635	0.000593	0.000443	0.000186	0.000360	0.000385	0.000137	0.000534	0.000174	0.000373	0.000510	0.001330	0.002050	0.001143	0.002088	0.001031	0.000833	0.001193	0.000932	0.000746	0.000895	0.001305	0.000211	0.000336	0.000360	0.000385	0.000336	0.000261	0.000360	0.000311	0.000236	0.000373	0.000224	0.000099	0.000112	0.000336	0.000311	0.000360	0.000497	0.000485	0.000273	0.000460	0.000186	0.000186	0.000186	0.000323	0.000249	0.000360	0.000124	0.000447	0.000746	0.000460	0.000311	0.000348	0.000572	0.000348	0.000174	0.000373	0.000298	0.000199	0.000137	0.000323	0.000162	0.000249	0.000485	0.000186	0.000497	0.000236	0.000497	0.000249	0.000186	0.000522	0.000584	0.000522	0.001118	0.001031	0.000385	0.000572	0.000373	0.000298	0.000770	0.000572
27-hydroxy-cholesterol	0.001615	0.002137	0.000928	0.001120	0.000708	0.000843	0.000608	0.000523	0.000920	0.000758	0.001181	0.000360	0.000472	0.001168	0.000286	0.000360	0.001181	0.000758	0.001255	0.001379	0.001653	0.001939	0.000808	0.000659	0.004449	0.000348	0.000460	0.001516	0.000820	0.000895	0.000833	0.000621	0.001665	0.000671	0.001131	0.001429	0.001255	0.000808	0.000410	0.001280	0.001181	0.001355	0.000895	0.001255	0.001094	0.000596	0.000683	0.001081	0.000895	0.000609	0.000944	0.000609	0.000510	0.001765	0.001205	0.001740	0.002137	0.001305	0.001504	0.000795	0.000646	0.000932	0.001118	0.001205	0.001143	0.000646	0.000708	0.001280	0.001168	0.000982	0.001466	0.000957	0.001603	0.000969	0.001031	0.001392	0.001243	0.001205	0.000447	0.001516	0.001864	0.000522	0.000659	0.000920	0.001131	0.000783	0.001901	0.000298
24-oxocholesterol	0.001204	0.000548	0.000484	0.000393	0.000663	0.000415	0.000291	0.000412	0.000297	0.001624	0.000924	0.000662	0.000262	0.000437	0.000250	0.000275	0.000337	0.001973	0.001873	0.002973	0.002123	0.001961	0.001786	0.003197	0.002036	0.001586	0.001561	0.001299	0.000525	0.000412	0.000462	0.000500	0.000425	0.000412	0.000325	0.000387	0.000337	0.001923	0.000350	0.005383	0.002760	0.003047	0.002798	0.003222	0.001973	0.000600	0.003260	0.002973	0.003210	0.003210	0.003709	0.000949	0.002061	0.005446	0.002498	0.003485	0.003147	0.002685	0.003522	0.001561	0.001961	0.004921	0.002973	0.002585	0.007681	0.003522	0.002348	0.003722	0.002910	0.003922	0.002985	0.003535	0.003759	0.002635	0.000774	0.002198	0.003610	0.002311	0.000525	0.000512	0.001049	0.000787	0.000537	0.000550	0.000637	0.000500	0.000437	0.001099
24,25-epoxy-cholesterol	0.000109	0.000028	0.000010	0.000024	ND	0.000029	0.000023	0.000071	0.000107	0.000025	0.000012	0.000025	0.000012	0.000025	0.000012	0.000012	0.000025	0.000087	0.000125	0.000125	0.000087	0.000112	0.000112	0.000112	0.000075	0.000100	0.000050	0.000075	0.000012	0.000012	0.000012	0.000012	0.000012	ND	0.000037	0.000012	ND	0.000025	0.000112	0.000012	0.000012	ND	0.000012	0.000012	0.000037	0.000025	0.000037	0.000037	0.000025	0.000012	0.000025	0.000012	0.000012	0.000012	0.000012	0.000012	0.000012	0.000012	0.000012	0.000025	0.000012	0.000012	0.000012	0.000012		0.000012	0.000012	0.000012	0.000012	0.000025	0.000025	0.000025	0.000025	0.000025	0.000037	0.000012	0.000050	0.000025	0.000012	0.000025	0.000337	0.000287	0.000012	0.000075	0.000037	0.000012	0.000025	0.000137
3beta,5alpha,6beta-trihydroxycholestanol	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
20-hydroxycholesterol	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
7alpha-hydroxy-cholesterol	0.006828	0.005447	0.001579	0.001249	0.002013	0.001443	0.001215	0.003113	0.003102	0.001814	0.001789	0.001094	0.000994	0.002684	0.001081	0.001740	0.002187	0.002026	0.001690	0.003840	0.002846	0.005033	0.001777	0.002274	0.001752	0.001491	0.001143	0.001988	0.003181	0.003741	0.002697	0.003281	0.004971	0.002523	0.004697	0.004126	0.003169	0.002299	0.002635	0.001628	0.001255	0.002100	0.001963	0.001504	0.001901	0.002224	0.002759	0.002659	0.001839	0.001665	0.002895	0.001504	0.002212	0.002709	0.002548	0.003156	0.006064	0.002150	0.001616	0.001777	0.001529	0.002001	0.001392	0.002622	0.002920	0.001268	0.001417	0.001814	0.002535	0.002249	0.002746	0.001603	0.002311	0.002137	0.004673	0.003219	0.001479	0.002200	0.007568	0.002846	0.003318	0.003206	0.003778	0.002895	0.002423	0.001901	0.003629	0.003368
7-oxo-cholesterol	0.009942	0.007447	0.002540	0.002540	0.007125	0.002968	0.002978	0.012889	0.003247	0.009367	0.011903	0.003172	0.001399	0.008331	0.003560	0.004484	0.010179	0.007194	0.005296	0.006420	0.006794	0.003422	0.004784	0.007781	0.006107	0.004371	0.003510	0.003247	0.007107	0.005520	0.004309	0.018023	0.006345	0.013127	0.008043	0.006620	0.008605	0.003734	0.009005	0.005658	0.001162	0.002123	0.002061	0.009442	0.007794	0.010616	0.005683	0.009979	0.008193	0.006132	0.015113	0.001624	0.004684	0.006794	0.005770	0.006445	0.005895	0.003834	0.001848	0.004759	0.002435	0.007007	0.007831	0.017935	0.012390	0.002036	0.006157	0.015113	0.002111	0.009205	0.005820	0.008156	0.003734	0.006482	0.018472	0.007431	0.001112	0.008955	0.039867	0.004796	0.004471	0.006045	0.006757	0.004908	0.003385	0.003684	0.007044	0.004596
19-hydroxycholesterol	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
6alpha-hydroxy-cholestanol	0.000132	ND	ND	0.000228	0.000232	0.000163	ND	0.000253	0.000125	0.000050	0.000037	0.000037	0.000050	0.000025	0.000062	0.000062	0.000050	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	0.000099	0.000149	0.000062	0.000050	0.000062	0.000062	0.000087	0.000062	0.000087	ND	0.000112	0.000050	ND	ND	0.000075	ND	0.000099	0.000099	0.000099	0.000050	ND	0.000075	0.000124	ND	0.000062	ND	ND	0.000062	0.000149	0.000087	ND	ND	0.000137	ND	0.000062	0.000112	0.000099	0.000087	0.000062	ND	0.000062	0.000087	ND	0.000062	ND	0.000037	ND	ND	ND	ND	0.000137	0.000062	0.000012	0.000087	0.000037	0.000050	0.000025	0.000050	0.000037	0.000075
5alpha-hydroxycholesterol	0.001282	0.001252	0.000484	0.000331	0.000892	0.000401	ND	0.001772	0.000466	0.000696	0.000708	0.000460	0.000336	0.000323	0.000249	0.000485	0.000634	0.000659	0.000360	0.001044	0.000671	0.000485	0.000286	0.000721	0.000447	0.000460	0.000398	0.000137	0.000795	0.000435	0.000770	0.000224	0.000746	0.000721	0.000572	0.000211	0.000087	0.000969	0.000795	0.000435	0.000360	0.000708	0.000795	0.000547	0.000671	0.000746	0.000311	0.000758	0.000273	0.000559	0.000870	0.000472	0.000708	0.001156	0.000472	0.001292	0.001876	0.000708	0.000460	0.000522	0.000646	0.000721	0.000485	0.000360	0.001131	0.000410	0.000534	0.000360	0.000559	0.000783	0.000857	0.000497	0.000447	0.000634	0.001243	0.000833	0.000348	0.000659	0.000410	0.000472	0.000547	0.000435	0.000423	0.000460	0.000348	0.000472	0.000447	0.000311
5,6beta-epoxy-cholesterol	0.008286	0.005726	0.002610	0.001717	0.005760	0.002595	0.002454	0.017087	0.001496	0.002933	0.002510	0.002100	0.001143	0.001429	0.001193	0.002635	0.001740	0.003604	0.002361	0.002510	0.004561	0.001765	0.002137	0.004760	0.004387	0.003430	0.002423	0.002597	0.005008	0.003691	0.005232	0.008401	0.004946	0.003629	0.005828	0.004735	0.005816	0.005468	0.004163	0.002137	0.004722	0.003069	0.003554	0.002398	0.004163	0.006549	0.003057	0.003989	0.002187	0.003492	0.005592	0.002585	0.004523	0.004325	0.002374	0.007953	0.008326	0.004188	0.001951	0.002311	0.004536	0.002858	0.002448	0.002026	0.010426	0.002113	0.002187	0.002597	0.002659	0.002485	0.002908	0.003156	0.002995	0.003094	0.007295	0.003952	0.002038	0.002958	0.007245	0.005021	0.005095	0.004635	0.003579	0.004101	0.002771	0.004635	0.004598	0.002647
5,6alpha-epoxy-cholesterol	0.004680	0.002039	0.001110	0.001077	0.002398	0.001414	0.001177	0.005058	0.001088	0.000870	0.000845	0.000596	0.000472	0.000596	0.000547	0.000870	0.000596	0.001292	0.000920	0.001355	0.001715	0.000882	0.001044	0.001616	0.001379	0.001280	0.001143	0.001094	0.002461	0.002001	0.002386	0.002436	0.002200	0.001827	0.003045	0.002485	0.003132	0.002038	0.001702	0.000808	0.000895	0.001205	0.001255	0.001156	0.001529	0.001616	0.001268	0.001591	0.000833	0.001031	0.001777	0.001143	0.001379	0.001740	0.000783	0.002386	0.003368	0.001603	0.001019	0.000932	0.001330	0.001268	0.001181	0.001205	0.002560	0.001019	0.001168	0.000845	0.001019	0.001268	0.001218	0.001156	0.001156	0.001292	0.004673	0.001392	0.000895	0.000969	0.002100	0.001491	0.001479	0.001777	0.001143	0.001429	0.000969	0.001292	0.001292	0.001031
4beta-hydroxy-cholesterol	0.000553	0.001102	0.000492	0.002575	0.000376	0.000978	0.000611	0.000349	0.000372	0.000920	0.000820	0.000795	0.000944	0.000621	0.000510	0.000398	0.000497	0.000273	0.000398	0.000783	0.001143	0.000311	0.001205	0.001230	0.000435	0.000249	0.000721	0.000534	0.000596	0.001789	0.000708	0.000584	0.000485	0.005518	0.000808	0.000336	0.001094	0.000646	0.000398	0.000360	0.000634	0.001081	0.000920	0.000373	0.000708	0.001578	0.000360	0.000683	0.000385	0.001094	0.001479	0.000435	0.000485	0.000621	0.000373	0.000485	0.004163	0.001118	0.000447	0.000323	0.000659	0.000423	0.000857	0.001094	0.001069	0.000398	0.001218	0.000559	0.000522	0.000795	0.000559	0.000410	0.000559	0.000510	0.001479	0.000547	0.000584	0.000472	0.000783	0.000547	0.000249	0.000733	0.001591	0.000659	0.000423	0.000621	0.000808	0.000683
Zymosterol	ND	ND	ND	ND	ND	ND	ND	0.000455	0.001340	ND	ND	ND	ND	ND	ND	ND	ND	ND	0.000195	ND	0.000065	ND	0.000039	0.000078	ND	0.000117	0.000911	0.000299	ND	ND	0.000052	ND	0.000117	ND	0.000104	0.000169	ND	ND	ND	0.000104	0.000260	ND	ND	0.000221	0.000065	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	0.000351	ND	ND	ND	ND	ND	0.000247	ND	ND	ND	0.000208	0.001249	ND	0.000286	0.000156	0.000104	ND	0.000494	0.000091	ND	0.000143	ND	0.000455	ND	0.000247	ND	0.000260	ND	ND	0.000208
Desmosterol	0.008271	0.008936	0.003434	0.005022	0.013087	0.001951	0.007116	0.015650	0.002966	0.002888	0.004007	0.006635	0.003057	0.003981	0.001288	0.001626	0.005412	0.003226	0.006375	0.001600	0.009653	0.012138	0.003838	0.011318	0.005490	0.009770	0.002199	0.007584	0.005061	0.001782	0.004618	0.004957	0.006934	0.002134	0.005750	0.008326	0.004280	0.006166	0.002394	0.003421	0.004098	0.006583	0.005191	0.002875	0.006283	0.006388	0.009067	0.005945	0.004371	0.004423	0.001483	0.003330	0.002563	0.008443	0.004059	0.006270	0.013660	0.004657	0.016821	0.002576	0.008235	0.004800	0.002810	0.003812	0.004566	0.006283	0.003018	0.004319	0.011084	0.030975	0.007168	0.002134	0.007077	0.004254	0.007936	0.004826	0.002550	0.004293	0.001847	0.004410	0.011110	0.005451	0.003083	0.004254	0.012684	0.006908	0.008651	0.001860
14-demethyl-14-dehydrolanosterol	0.000666	0.000656	0.000889	0.000231	0.000097	0.000268	0.000158	0.000195	0.002009	0.000292	0.001120	0.000268	0.000280	0.000609	0.000097	0.000158	0.000743	0.000183	0.000536	0.000804	0.000061	0.001461	0.000195	0.000134	0.000049	0.000170	0.000073	0.001303	0.000377	0.000645	0.000414	0.000450	0.000852	0.000061	0.000718	0.001644	0.000207	0.000158	0.000195	0.000256	0.000524	0.000767	0.000268	0.000731	0.000158	0.000231	0.000110	0.000499	0.000207	0.000085	0.000244	0.000134	0.000219	0.000280	0.000231	0.000353	0.000877	0.000110	0.000621	0.000877	0.000061	0.000256	0.000134	0.000183	0.000085	0.000110	0.000158	0.000329	0.000487	0.000268	0.000377	0.000341	0.000426	0.000097	0.000560	0.001157	0.000195	0.000889	0.000146	0.000146	0.000852	0.000390	0.000511	0.000304	0.001583	0.000609	0.000511	0.000268
8-Dehydrochol	0.004629	0.009337	0.004592	0.004683	0.004423	0.001717	0.004696	0.004696	0.014544	0.003539	0.004631	0.002277	0.002524	0.020490	0.017133	0.004124	0.007506	0.003786	0.004592	0.094005	0.006531	0.009835	0.001717	0.003838	0.002225	0.001990	0.008846	0.011058	0.003343	0.035633	0.003890	0.005945	0.010407	0.001938	0.009874	0.009913	0.005581	0.003890	0.001639	0.007936	0.004670	0.002953	0.004423	0.006101	0.002615	0.002680	0.002147	0.002003	0.002758	0.002407	0.005048	0.005672	0.010720	0.005464	0.022519	0.008872	0.019033	0.004202	0.003669	0.012671	0.002940	0.003591	0.002003	0.001821	0.002563	0.001847	0.002602	0.004059	0.004150	0.000351	0.007246	0.006817	0.003825	0.003812	0.006791	0.009041	0.005958	0.042606	0.006427	0.005620	0.007090	0.003799	0.024314	0.003278	0.002719	0.005165	0.007259	0.038456
7-Dehydrochol	0.007011	0.007756	0.005880	0.005204	0.003395	0.002979	0.003864	0.005087	0.042397	0.004696	0.008001	0.004592	0.005607	0.012671	0.013465	0.009835	0.007897	0.004319	0.005867	0.074595	0.004735	0.005243	0.004852	0.004332	0.003395	0.004384	0.004566	0.008937	0.003460	0.047770	0.003994	0.005542	0.007689	0.003369	0.006518	0.007350	0.004944	0.007168	0.004332	0.006049	0.006622	0.010707	0.005971	0.007168	0.004683	0.004957	0.003942	0.008170	0.004475	0.007376	0.012697	0.006856	0.010147	0.007272	0.005802	0.016236	0.022298	0.010225	0.006101	0.027411	0.006153	0.006179	0.005503	0.005607	0.004931	0.005074	0.005334	0.006570	0.005568	0.005724	0.008118	0.012294	0.006947	0.005607	0.010538	0.014466	0.006726	0.051777	0.006713	0.006440	0.005633	0.003682	0.018460	0.005113	0.006596	0.004371	0.006531	0.044102
Cholestenone	0.000246	0.000600	0.000377	0.000208	0.000429	0.000273	0.000312	0.000260	0.000312	0.000768	0.000585	0.000312	0.000377	0.000559	0.000195	0.000364	0.000689	0.000169	0.000273	0.000286	0.000377	0.000703	0.000299	0.000273	0.000169	0.000221	0.000390	0.000624	0.000286	0.000507	0.000312	0.000247	0.000325	0.000143	0.000377	0.000364	0.000507	0.000481	0.000377	0.000169	0.000572	0.000364	0.000716	0.000169	0.000937	0.000885	0.000156	0.000742	0.000429	0.000676	0.001119	0.000742	0.000273	0.000794	0.000221	0.000950	0.003565	0.001093	0.000585	0.000598	0.000611	0.000507	0.000195	0.000273	0.000221	0.000364	0.000768	0.000429	0.000755	0.000377	0.000742	0.000520	0.000585	0.001093	0.000273	0.000572	0.000312	0.000260	0.000572	0.000455	0.000807	0.000364	0.000312	0.000416	0.000637	0.000546	0.000598	0.000494
14-Demethyllanosterol	0.004467	0.006370	0.004899	0.004838	0.005420	0.003904	0.004777	0.006172	0.003747	0.003468	0.003892	0.004450	0.004947	0.004802	0.004304	0.003213	0.004802	0.006390	0.004462	0.007142	0.012380	0.004547	0.007675	0.011373	0.008657	0.004692	0.009736	0.006923	0.002910	0.008063	0.003140	0.005517	0.003456	0.015750	0.003359	0.002546	0.021898	0.003407	0.003929	0.002655	0.003832	0.022116	0.003710	0.002219	0.003383	0.010149	0.005517	0.004341	0.002946	0.004826	0.041055	0.002364	0.002849	0.006851	0.011664	0.008451	0.014017	0.004511	0.004850	0.001746	0.009458	0.004802	0.005371	0.007906	0.006111	0.005978	0.003092	0.005262	0.003213	0.005565	0.003068	0.002777	0.003347	0.003153	0.005371	0.003844	0.003286	0.004426	0.003601	0.006499	0.004171	0.003031	0.001928	0.003262	0.003565	0.002765	0.002158	0.003347
Lanosterol	0.000010	0.000010	0.000016	0.000002	0.000004	0.000006	0.000004	0.000002	0.000027	0.001794	0.005136	0.005160	0.002463	0.001478	0.000786	0.000739	0.004843	0.001771	0.006004	0.005863	0.002744	0.015373	0.002779	0.001747	0.000879	0.000915	0.002592	0.008631	0.008291	0.006942	0.003131	0.007059	0.013755	0.003389	0.006836	0.009991	0.005887	0.002908	0.003236	0.003166	0.003577	0.009838	0.002146	0.004913	0.001958	0.001266	0.001055	0.005300	0.003131	0.000199	0.002885	0.001736	0.002146	0.003999	0.001653	0.003799	0.007552	0.001900	0.005980	0.006051	0.000457	0.002521	0.000797	0.002240	0.001302	0.001079	0.001829	0.003448	0.006438	0.005207	0.004468	0.001278	0.005910	0.002943	0.007493	0.006942	0.002334	0.006426	0.001231	0.000985	0.007212	0.003881	0.008244	0.005863	0.012582	0.008220	0.004304	0.001736
Cholestanol	0.036346	0.022560	0.018024	0.034902	0.046193	0.027937	0.035379	0.047081	0.015488	0.021616	0.014162	0.028735	0.019723	0.015771	0.037645	0.015784	0.020135	0.013904	0.021423	0.016724	0.072302	0.022878	0.023946	0.042974	0.025350	0.026959	0.075083	0.023290	0.019749	0.056068	0.016775	0.036434	0.039267	0.034220	0.036537	0.016067	0.029302	0.019105	0.030396	0.010299	0.015076	0.016569	0.015514	0.009154	0.032508	0.046708	0.017445	0.013132	0.012758	0.028761	0.026727	0.013441	0.013582	0.021899	0.014947	0.021487	0.047197	0.027525	0.014097	0.011059	0.050158	0.019453	0.019427	0.013982	0.026920	0.040593	0.017084	0.012707	0.023406	0.020959	0.019814	0.012334	0.015089	0.015372	0.016041	0.012977	0.010235	0.014805	0.017187	0.019492	0.016801	0.012733	0.010093	0.009514	0.012527	0.016659	0.019672	0.011317
Campesterol	0.072275	0.037081	0.033132	0.043834	0.057110	0.039426	0.042948	0.053613	0.040400	0.039289	0.053226	0.043322	0.054038	0.051815	0.042173	0.039189	0.054937	0.041287	0.055736	0.075018	0.119127	0.047781	0.050416	0.071971	0.062642	0.039239	0.062979	0.064328	0.040350	0.083648	0.043897	0.047544	0.039164	0.049105	0.057384	0.057397	0.041149	0.039301	0.040887	0.029598	0.034031	0.035142	0.035167	0.029610	0.029273	0.086470	0.038989	0.044359	0.030147	0.040712	0.035068	0.033369	0.033994	0.046345	0.044521	0.054175	0.094538	0.057971	0.032994	0.031383	0.068287	0.040038	0.047556	0.037565	0.038227	0.042661	0.031833	0.033844	0.031009	0.033594	0.055087	0.029310	0.034730	0.030347	0.056260	0.049816	0.028599	0.045845	0.033606	0.059620	0.036941	0.041099	0.042760	0.049929	0.047069	0.038527	0.039651	0.041462
Stigmasterol	0.002629	0.001968	0.002073	0.002886	0.002207	0.001795	0.001770	0.002813	0.001516	0.003771	0.002183	0.002304	0.002219	0.003262	0.003771	0.002886	0.003577	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	0.001297	0.005505	0.001297	0.001928	0.001601	0.006390	0.002849	0.001431	0.009264	0.002389	0.002013	0.003807	0.003444	0.012974	0.003322	0.002607	0.002037	0.004705	0.003589	0.004147	0.003274	0.003274	0.023995	0.002049	0.002413	0.005832	0.007493	0.005772	0.009603	0.003492	0.003904	0.001564	0.005384	0.005129	0.004753	0.005299	0.006050	0.004899	0.002801	0.004656	0.003638	0.004608	0.003795	0.003541	0.003165	0.002849	0.005020	0.003856	0.003262	0.003625	0.002377	0.004050	0.002195	0.003347	0.001091	0.003201	0.003092	0.002267	0.002522	0.002728
Sitosterol	0.022684	0.015324	0.010449	0.016977	0.028536	0.008784	0.013924	0.020222	0.015517	0.017411	0.015758	0.020138	0.017194	0.017206	0.021912	0.010256	0.015094	0.023348	0.023999	0.028114	0.054164	0.019185	0.022672	0.047672	0.037658	0.021140	0.044970	0.036367	0.008965	0.053609	0.010799	0.016627	0.009544	0.054200	0.018413	0.010558	0.060269	0.018256	0.015999	0.023661	0.022672	0.085125	0.025797	0.017001	0.015191	0.043256	0.031577	0.024614	0.019764	0.024409	0.140206	0.014177	0.017230	0.042581	0.046357	0.037537	0.069234	0.028355	0.024289	0.011282	0.043980	0.033024	0.032047	0.037839	0.039106	0.034895	0.018509	0.028958	0.018931	0.028041	0.016132	0.023106	0.021948	0.016892	0.031009	0.024578	0.020983	0.024144	0.018280	0.029718	0.016723	0.019957	0.011077	0.019197	0.021429	0.016567	0.016518	0.019197
24-dihydro Lanosterol	ND	ND	ND	ND	ND	ND	ND	ND	ND	0.000584	0.000945	0.001085	0.000712	0.000630	0.000642	0.000432	0.000957	0.001155	0.002206	0.001599	0.002603	0.002148	0.001424	0.001249	0.000910	0.000992	0.001389	0.001482	0.001074	0.003653	0.000945	0.001284	0.001482	0.001611	0.001331	0.001272	0.001552	0.001377	0.000910	0.001167	0.000957	0.001692	0.000992	0.001062	0.000747	0.000934	0.000712	0.001284	0.000922	0.000817	0.001342	0.000840	0.000595	0.001716	0.001202	0.001027	0.003373	0.000817	0.000957	0.000817	0.001284	0.001144	0.000689	0.000969	0.001167	0.000794	0.000934	0.001377	0.001727	0.000934	0.002007	0.000782	0.001109	0.000992	0.001471	0.001389	0.000782	0.001366	0.000922	0.000887	0.001307	0.000817	0.001681	0.001039	0.001342	0.001039	0.000969	0.000782
Stigmastanol	0.005106	0.001515	0.000072	0.002726	0.001453	0.001069	0.001033	0.001237	0.001189	0.001285	0.000901	0.000672	0.000865	0.000805	0.000793	0.000564	0.000504	0.000829	0.000648	0.001297	0.000961	0.000276	0.001177	0.000877	0.000853	0.001129	0.001345	0.000336	0.000588	0.001429	0.001273	0.003518	0.000913	0.001897	0.002161	0.004227	0.001681	0.000973	0.000925	0.000672	0.000901	0.001789	0.001609	0.000805	0.000889	0.001261	0.001201	0.000985	0.001837	0.000588	0.001933	0.002474	0.000468	0.001261	0.001081	0.001417	0.002690	0.000612	0.001033	0.000384	0.000744	0.000853	0.000877	0.002029	0.001213	0.001573	0.001453	0.001669	0.000612	0.000600	0.006844	0.000660	0.000768	0.001033	0.000720	0.001069	0.000480	0.002450	0.002341	0.001165	0.000348	0.000480	0.000216	0.000180	0.001141	0.000961	0.003086	0.000780
Cholesterol-free	not measured	not measured	6.046812	6.673995	5.457132	4.562266	4.620458	4.449761	5.771369	5.432562	8.056382	4.435536	5.507565	8.005949	4.736842	4.558386	6.773568	5.136428	4.598474	4.401914	5.618777	4.633389	6.101125	4.363119	4.381223	3.946722	5.272210	8.313720	4.817018	9.582310	6.180008	4.699340	10.880641	6.288633	6.959783	4.776930	4.013966	5.925255	5.991207	3.721712	4.224751	8.715893	5.644640	4.624337	4.740722	5.299366	5.710591	7.861115	5.017458	4.695461	4.372171	4.687702	3.318246	7.817147	4.846761	8.039571	25.194620	6.794258	4.845467	4.775637	6.163197	6.610630	9.323678	6.583473	5.106686	4.797621	6.150265	5.263158	6.001552	4.751067	8.311134	5.834734	6.114057	7.086512	10.285788	5.495927	4.352774	6.705030	3.884650	5.320057	5.176516	5.635588	4.965731	3.726885	4.718738	3.826458	8.723652	5.132549
Cholesterol-total	not measured	not measured	13.267813	11.884133	10.332342	7.513255	11.741885	11.366869	8.534851	9.879736	16.203285	9.207293	7.371007	11.043579	7.784818	8.909867	10.694426	8.987456	12.116902	10.616837	9.802147	9.970257	17.211949	11.147032	9.271951	10.797879	9.530583	14.379930	12.453123	14.793741	8.366740	8.935730	15.155826	10.836674	14.004914	8.030519	9.310746	8.483124	11.522048	7.228760	10.707358	12.039312	9.284883	7.474460	11.185827	11.302211	62.627699	13.901461	9.944394	7.448597	10.164231	11.315143	11.470322	12.918660	10.539247	14.418725	42.105263	13.073839	9.271951	6.750291	8.250356	7.539118	13.655761	9.892668	15.078236	12.065175	9.582310	13.875598	8.819346	10.397000	15.504979	10.862537	12.996250	15.181689	20.354326	9.685762	6.090780	18.673219	10.435795	17.522307	20.897452	16.552438	6.608043	10.953058	12.310875	9.672831	12.039312	9.698694
3-oxo,7alpha-hydroxycholesterol	not measured	not measured	0.000736	0.000087	0.000100	0.000237	0.000237	0.000100	0.002034	0.000187	0.000362	0.000300	0.000250	0.003657	0.000549	0.000250	0.002496	0.000786	0.001884	0.001323	0.000262	0.002558	0.000499	0.000262	0.000612	0.000137	0.000200	0.002970	0.000499	0.001585	0.000774	0.001248	0.001847	0.001123	0.002221	0.002434	0.000886	0.000936	0.001023	0.000986	0.001023	0.001710	0.001622	0.000961	0.000125	0.000175	0.000524	0.000799	0.000462	0.000125	0.000125	0.000761	0.001922	0.002022	0.003157	0.000300	xx	0.000449	0.001423	0.000661	0.000112	0.001959	0.000487	0.000262	0.001073	0.000100	0.000312	0.000686	0.000699	0.000574	0.002384	0.000612	0.000899	0.000499	0.000711	0.003682	0.000874	0.001248	0.000998	0.001373	0.003682	0.000899	0.001073	0.001123	0.001410	0.000524	0.001136	0.001810
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name
7alpha,25-dihydroxycholesterol
7alpha,27-dihydroxy cholesterol
7alpha,24S-dihydroxycholesterol
5alpha,6alpha-24S,25-diepoxy-cholesterol
25-hydroxy Vitamin D3
25-hydroxy Vitamin D2
22R-hydroxy-cholesterol
25-hydroxy-cholesterol
24S-hydroxy-cholesterol
27-hydroxy-cholesterol
24-oxocholesterol
24,25-epoxy-cholesterol
3beta,5alpha,6beta-trihydroxycholestanol
20-hydroxycholesterol
7alpha-hydroxy-cholesterol
7-oxo-cholesterol
19-hydroxycholesterol
6alpha-hydroxy-cholestanol
5alpha-hydroxycholesterol
5,6beta-epoxy-cholesterol
5,6alpha-epoxy-cholesterol
4beta-hydroxy-cholesterol
Zymosterol
Desmosterol
14-demethyl-14-dehydrolanosterol
8-Dehydrochol
7-Dehydrochol
Cholestenone
14-Demethyllanosterol
Lanosterol
Cholestanol
Campesterol
Stigmasterol
Sitosterol
24-dihydro Lanosterol
Stigmastanol
Cholesterol-free
Cholesterol-total
3-oxo,7alpha-hydroxycholesterol
METABOLITES_END
#END