#METABOLOMICS WORKBENCH kenanazam_20181205_120324 DATATRACK_ID:1584 STUDY_ID:ST001109 ANALYSIS_ID:AN001803 PROJECT_ID:PR000740
VERSION             	1
CREATED_ON             	December 5, 2018, 12:21 pm
#PROJECT
PR:PROJECT_TITLE                 	Chronic Maternal Cortisol Excess During Late Gestation Leads to Metabolic
PR:PROJECT_TITLE                 	Alterations in the Newborn Heart
PR:PROJECT_SUMMARY               	Our laboratory has previously shown in an ovine model of pregnancy that abnormal
PR:PROJECT_SUMMARY               	elevations in maternal cortisol during late gestation lead to increased fetal
PR:PROJECT_SUMMARY               	cardiac arrhythmias and mortality during peripartum. Furthermore, transcriptomic
PR:PROJECT_SUMMARY               	analysis of the fetal heart suggested alterations in TCA cycle intermediates and
PR:PROJECT_SUMMARY               	lipid metabolites in animals exposed to excess cortisol in utero. Therefore, we
PR:PROJECT_SUMMARY               	utilized a sheep model of pregnancy to determine how chronic increases in
PR:PROJECT_SUMMARY               	maternal cortisol alter maternal and fetal serum prior to birth and neonatal
PR:PROJECT_SUMMARY               	cardiac metabolites and lipids at term. Ewes were either infused with 1
PR:PROJECT_SUMMARY               	mg/kg/day of cortisol starting at gestational day 115 (n=9), or untreated (n=6).
PR:PROJECT_SUMMARY               	Serum was collected from the mother and fetus (125 d-birth), and hearts were
PR:PROJECT_SUMMARY               	collected following birth. Proton nuclear magnetic resonance (1H-NMR)
PR:PROJECT_SUMMARY               	spectroscopy was conducted to measure metabolic profiles of newborn heart
PR:PROJECT_SUMMARY               	specimens as well as fetal and maternal serum specimens. Mass spectrometry was
PR:PROJECT_SUMMARY               	conducted to measure lipid profiles of newborn heart specimens. We observed
PR:PROJECT_SUMMARY               	alterations in amino acid and TCA cycle metabolism as well as lipid and
PR:PROJECT_SUMMARY               	glycerophospholipid metabolism in newborn hearts after excess maternal cortisol
PR:PROJECT_SUMMARY               	in late gestation. In addition, we observed alterations in amino acid and TCA
PR:PROJECT_SUMMARY               	cycle metabolites in fetal but not in maternal serum during late gestation.
PR:PROJECT_SUMMARY               	These results suggest that fetal exposure to excess maternal cortisol alters
PR:PROJECT_SUMMARY               	placental and fetal metabolism prior to birth and limits normal cardiac
PR:PROJECT_SUMMARY               	metabolic maturation, which may contribute to increased risk of peripartum
PR:PROJECT_SUMMARY               	cardiac arrhythmias observed in these animals, or later life cardiomyopathies.
PR:INSTITUTE                     	University of Florida
PR:LAST_NAME                     	Keller-Wood
PR:FIRST_NAME                    	Maureen
PR:ADDRESS                       	1345 SW Archer Rd, PO 100487, Gainesville, FL, 32610
PR:EMAIL                         	kellerwd@cop.ufl.edu
PR:PHONE                         	na
#STUDY
ST:STUDY_TITLE                   	NMR Metabolomics of Newborn Heart Tissue Exposed to Excess Maternal Cortisol in
ST:STUDY_TITLE                   	Late Gestation - Maternal (part -IV)
ST:STUDY_TYPE                    	Comparison
ST:STUDY_SUMMARY                 	Serum from mothers and fetuses exposed to excess maternal cortisol in late
ST:STUDY_SUMMARY                 	gestation and untreated was compared via NMR metabolomic analysis
ST:INSTITUTE                     	University of Florida
ST:DEPARTMENT                    	Biochemsitry & Molecular Biology
ST:LAST_NAME                     	Walejko
ST:FIRST_NAME                    	Jacquelyn
ST:ADDRESS                       	R3-226 Academic Research Building, Department of Biochemistry and Molecular
ST:ADDRESS                       	Biology, PO Box 100245, Gainesville, FL 32610-0245
ST:EMAIL                         	jwalejko@uga.edu
ST:PHONE                         	NA
ST:NUM_GROUPS                    	2
ST:TOTAL_SUBJECTS                	36
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Ovis aries
SU:TAXONOMY_ID                   	9940
SU:AGE_OR_AGE_RANGE              	Gestational days 125-birth
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	729	F_729_130	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=130; Batch=1; NMR_ID=4
SUBJECT_SAMPLE_FACTORS           	770	F_770_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=1; NMR_ID=6
SUBJECT_SAMPLE_FACTORS           	759	F_759_125	Treatment:Control | Source:Fetal	Gestational Age (days)=125; Batch=1; NMR_ID=7
SUBJECT_SAMPLE_FACTORS           	759	F_759_146	Treatment:Control | Source:Fetal	Gestational Age (days)=146; Batch=1; NMR_ID=8
SUBJECT_SAMPLE_FACTORS           	728	M_728_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=1; NMR_ID=10
SUBJECT_SAMPLE_FACTORS           	729	F_729_125	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=125; Batch=1; NMR_ID=11
SUBJECT_SAMPLE_FACTORS           	770	M_770_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=1; NMR_ID=12
SUBJECT_SAMPLE_FACTORS           	734	M_734_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=1; NMR_ID=13
SUBJECT_SAMPLE_FACTORS           	759	M_759_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=1; NMR_ID=14
SUBJECT_SAMPLE_FACTORS           	770	M_770_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=1; NMR_ID=15
SUBJECT_SAMPLE_FACTORS           	734	M_734_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=1; NMR_ID=16
SUBJECT_SAMPLE_FACTORS           	728	F_728_146	Treatment:Control | Source:Fetal	Gestational Age (days)=146; Batch=1; NMR_ID=18
SUBJECT_SAMPLE_FACTORS           	759	M_759_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=1; NMR_ID=19
SUBJECT_SAMPLE_FACTORS           	759	M_759_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=1; NMR_ID=20
SUBJECT_SAMPLE_FACTORS           	706	M_706_140	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=140; Batch=1; NMR_ID=21
SUBJECT_SAMPLE_FACTORS           	729	F_729_135	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=135; Batch=1; NMR_ID=22
SUBJECT_SAMPLE_FACTORS           	728	M_728_147	Treatment:Control | Source:Maternal	Gestational Age (days)=147; Batch=1; NMR_ID=23
SUBJECT_SAMPLE_FACTORS           	770	M_770_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=1; NMR_ID=24
SUBJECT_SAMPLE_FACTORS           	759	F_759_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=1; NMR_ID=25
SUBJECT_SAMPLE_FACTORS           	759	M_759_147	Treatment:Control | Source:Maternal	Gestational Age (days)=147; Batch=1; NMR_ID=27
SUBJECT_SAMPLE_FACTORS           	734	M_734_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=1; NMR_ID=28
SUBJECT_SAMPLE_FACTORS           	734	F_734_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=1; NMR_ID=29
SUBJECT_SAMPLE_FACTORS           	706	F_706_142	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=142; Batch=1; NMR_ID=34
SUBJECT_SAMPLE_FACTORS           	770	F_770_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=1; NMR_ID=35
SUBJECT_SAMPLE_FACTORS           	734	M_734_144	Treatment:Control | Source:Maternal	Gestational Age (days)=144; Batch=1; NMR_ID=37
SUBJECT_SAMPLE_FACTORS           	706	F_706_140	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=140; Batch=1; NMR_ID=38
SUBJECT_SAMPLE_FACTORS           	728	F_728_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=1; NMR_ID=40
SUBJECT_SAMPLE_FACTORS           	759	F_759_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=1; NMR_ID=41
SUBJECT_SAMPLE_FACTORS           	728	F_728_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=1; NMR_ID=42
SUBJECT_SAMPLE_FACTORS           	729	M_729_130	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=130; Batch=1; NMR_ID=43
SUBJECT_SAMPLE_FACTORS           	728	M_728_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=1; NMR_ID=45
SUBJECT_SAMPLE_FACTORS           	759	M_759_145	Treatment:Control | Source:Maternal	Gestational Age (days)=145; Batch=1; NMR_ID=46
SUBJECT_SAMPLE_FACTORS           	728	M_728_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=1; NMR_ID=47
SUBJECT_SAMPLE_FACTORS           	770	F_770_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=1; NMR_ID=48
SUBJECT_SAMPLE_FACTORS           	728	F_728_138	Treatment:Control | Source:Fetal	Gestational Age (days)=138; Batch=1; NMR_ID=50
SUBJECT_SAMPLE_FACTORS           	728	F_728_147	Treatment:Control | Source:Fetal	Gestational Age (days)=147; Batch=1; NMR_ID=51
SUBJECT_SAMPLE_FACTORS           	770	F_770_125	Treatment:Control | Source:Fetal	Gestational Age (days)=125; Batch=1; NMR_ID=55
SUBJECT_SAMPLE_FACTORS           	706	M_706_142	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=142; Batch=1; NMR_ID=56
SUBJECT_SAMPLE_FACTORS           	770	F_770_138	Treatment:Control | Source:Fetal	Gestational Age (days)=138; Batch=1; NMR_ID=58
SUBJECT_SAMPLE_FACTORS           	706	M_706_130	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=130; Batch=1; NMR_ID=59
SUBJECT_SAMPLE_FACTORS           	734	F_734_125	Treatment:Control | Source:Fetal	Gestational Age (days)=125; Batch=1; NMR_ID=60
SUBJECT_SAMPLE_FACTORS           	734	F_734_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=1; NMR_ID=62
SUBJECT_SAMPLE_FACTORS           	706	F_706_138	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=138; Batch=1; NMR_ID=63
SUBJECT_SAMPLE_FACTORS           	734	M_734_142	Treatment:Control | Source:Maternal	Gestational Age (days)=142; Batch=1; NMR_ID=64
SUBJECT_SAMPLE_FACTORS           	759	F_759_145	Treatment:Control | Source:Fetal	Gestational Age (days)=145; Batch=1; NMR_ID=65
SUBJECT_SAMPLE_FACTORS           	759	F_759_142	Treatment:Control | Source:Fetal	Gestational Age (days)=142; Batch=1; NMR_ID=66
SUBJECT_SAMPLE_FACTORS           	759	F_759_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=1; NMR_ID=67
SUBJECT_SAMPLE_FACTORS           	734	F_734_138	Treatment:Control | Source:Fetal	Gestational Age (days)=138; Batch=1; NMR_ID=68
SUBJECT_SAMPLE_FACTORS           	706	M_706_135	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=135; Batch=1; NMR_ID=69
SUBJECT_SAMPLE_FACTORS           	734	M_734_143	Treatment:Control | Source:Maternal	Gestational Age (days)=143; Batch=1; NMR_ID=71
SUBJECT_SAMPLE_FACTORS           	728	M_728_142	Treatment:Control | Source:Maternal	Gestational Age (days)=142; Batch=1; NMR_ID=72
SUBJECT_SAMPLE_FACTORS           	728	M_728_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=1; NMR_ID=73
SUBJECT_SAMPLE_FACTORS           	728	M_728_146	Treatment:Control | Source:Maternal	Gestational Age (days)=146; Batch=1; NMR_ID=74
SUBJECT_SAMPLE_FACTORS           	734	F_734_143	Treatment:Control | Source:Fetal	Gestational Age (days)=143; Batch=1; NMR_ID=75
SUBJECT_SAMPLE_FACTORS           	728	F_728_144	Treatment:Control | Source:Fetal	Gestational Age (days)=144; Batch=1; NMR_ID=76
SUBJECT_SAMPLE_FACTORS           	706	F_706_135	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=135; Batch=1; NMR_ID=77
SUBJECT_SAMPLE_FACTORS           	734	M_734_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=1; NMR_ID=78
SUBJECT_SAMPLE_FACTORS           	734	M_734_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=1; NMR_ID=79
SUBJECT_SAMPLE_FACTORS           	706	M_706_138	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=138; Batch=1; NMR_ID=80
SUBJECT_SAMPLE_FACTORS           	728	F_728_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=1; NMR_ID=82
SUBJECT_SAMPLE_FACTORS           	770	M_770_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=1; NMR_ID=83
SUBJECT_SAMPLE_FACTORS           	759	M_759_146	Treatment:Control | Source:Maternal	Gestational Age (days)=146; Batch=1; NMR_ID=84
SUBJECT_SAMPLE_FACTORS           	728	F_728_142	Treatment:Control | Source:Fetal	Gestational Age (days)=142; Batch=1; NMR_ID=85
SUBJECT_SAMPLE_FACTORS           	759	F_759_138	Treatment:Control | Source:Fetal	Gestational Age (days)=138; Batch=1; NMR_ID=86
SUBJECT_SAMPLE_FACTORS           	759	M_759_142	Treatment:Control | Source:Maternal	Gestational Age (days)=142; Batch=1; NMR_ID=87
SUBJECT_SAMPLE_FACTORS           	734	F_734_142	Treatment:Control | Source:Fetal	Gestational Age (days)=142; Batch=1; NMR_ID=88
SUBJECT_SAMPLE_FACTORS           	759	F_759_147	Treatment:Control | Source:Fetal	Gestational Age (days)=147; Batch=1; NMR_ID=89
SUBJECT_SAMPLE_FACTORS           	759	M_759_144	Treatment:Control | Source:Maternal	Gestational Age (days)=144; Batch=1; NMR_ID=90
SUBJECT_SAMPLE_FACTORS           	734	F_734_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=1; NMR_ID=91
SUBJECT_SAMPLE_FACTORS           	759	F_759_144	Treatment:Control | Source:Fetal	Gestational Age (days)=144; Batch=1; NMR_ID=92
SUBJECT_SAMPLE_FACTORS           	729	M_729_125	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=125; Batch=1; NMR_ID=93
SUBJECT_SAMPLE_FACTORS           	759	M_759_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=1; NMR_ID=95
SUBJECT_SAMPLE_FACTORS           	734	F_734_144	Treatment:Control | Source:Fetal	Gestational Age (days)=144; Batch=1; NMR_ID=96
SUBJECT_SAMPLE_FACTORS           	770	M_770_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=1; NMR_ID=98
SUBJECT_SAMPLE_FACTORS           	728	M_728_144	Treatment:Control | Source:Maternal	Gestational Age (days)=144; Batch=1; NMR_ID=99
SUBJECT_SAMPLE_FACTORS           	759	M_759_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=1; NMR_ID=101
SUBJECT_SAMPLE_FACTORS           	729	M_729_135	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=135; Batch=1; NMR_ID=102
SUBJECT_SAMPLE_FACTORS           	753	M_753_143	Treatment:Control | Source:Maternal	Gestational Age (days)=143; Batch=2; NMR_ID=107
SUBJECT_SAMPLE_FACTORS           	753	M_753_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=2; NMR_ID=109
SUBJECT_SAMPLE_FACTORS           	753	M_753_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=2; NMR_ID=110
SUBJECT_SAMPLE_FACTORS           	753	F_753_143	Treatment:Control | Source:Fetal	Gestational Age (days)=143; Batch=2; NMR_ID=111
SUBJECT_SAMPLE_FACTORS           	802	M_802_142	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=142; Batch=2; NMR_ID=112
SUBJECT_SAMPLE_FACTORS           	802	F_802_135	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=135; Batch=2; NMR_ID=113
SUBJECT_SAMPLE_FACTORS           	802	F_802_138	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=138; Batch=2; NMR_ID=115
SUBJECT_SAMPLE_FACTORS           	767	F_767_125	Treatment:Control | Source:Fetal	Gestational Age (days)=120; Batch=2; NMR_ID=116
SUBJECT_SAMPLE_FACTORS           	753	F_753_138	Treatment:Control | Source:Fetal	Gestational Age (days)=138; Batch=2; NMR_ID=117
SUBJECT_SAMPLE_FACTORS           	767	F_767_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=2; NMR_ID=118
SUBJECT_SAMPLE_FACTORS           	767	M_767_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=2; NMR_ID=119
SUBJECT_SAMPLE_FACTORS           	767	M_767_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=2; NMR_ID=120
SUBJECT_SAMPLE_FACTORS           	802	F_802_125	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=125; Batch=2; NMR_ID=121
SUBJECT_SAMPLE_FACTORS           	753	M_753_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=2; NMR_ID=122
SUBJECT_SAMPLE_FACTORS           	802	F_802_130	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=130; Batch=2; NMR_ID=125
SUBJECT_SAMPLE_FACTORS           	802	M_802_130	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=130; Batch=2; NMR_ID=126
SUBJECT_SAMPLE_FACTORS           	802	F_802_142	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=142; Batch=2; NMR_ID=127
SUBJECT_SAMPLE_FACTORS           	802	M_802_135	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=135; Batch=2; NMR_ID=129
SUBJECT_SAMPLE_FACTORS           	802	F_802_140	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=140; Batch=2; NMR_ID=130
SUBJECT_SAMPLE_FACTORS           	753	F_753_125	Treatment:Control | Source:Fetal	Gestational Age (days)=125; Batch=2; NMR_ID=131
SUBJECT_SAMPLE_FACTORS           	753	F_753_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=2; NMR_ID=132
SUBJECT_SAMPLE_FACTORS           	767	M_767_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=2; NMR_ID=133
SUBJECT_SAMPLE_FACTORS           	802	M_802_125	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=125; Batch=2; NMR_ID=134
SUBJECT_SAMPLE_FACTORS           	767	M_767_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=2; NMR_ID=135
SUBJECT_SAMPLE_FACTORS           	802	M_802_140	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=140; Batch=2; NMR_ID=136
SUBJECT_SAMPLE_FACTORS           	767	F_767_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=2; NMR_ID=138
SUBJECT_SAMPLE_FACTORS           	802	M_802_138	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=138; Batch=2; NMR_ID=139
SUBJECT_SAMPLE_FACTORS           	802	M_802_147	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=147; Batch=2; NMR_ID=140
SUBJECT_SAMPLE_FACTORS           	802	M_802_144	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=144; Batch=2; NMR_ID=142
SUBJECT_SAMPLE_FACTORS           	753	M_753_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=2; NMR_ID=143
SUBJECT_SAMPLE_FACTORS           	753	F_753_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=2; NMR_ID=144
SUBJECT_SAMPLE_FACTORS           	753	M_753_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=2; NMR_ID=150
SUBJECT_SAMPLE_FACTORS           	753	F_753_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=2; NMR_ID=151
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_147	Treatment:Control | Source:Fetal	Gestational Age (days)=147; Batch=3; NMR_ID=154
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_144	Treatment:Control | Source:Fetal	Gestational Age (days)=144; Batch=3; NMR_ID=155
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_125	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=125; Batch=3; NMR_ID=157
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_141	Treatment:Control | Source:Maternal	Gestational Age (days)=141; Batch=3; NMR_ID=158
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=3; NMR_ID=159
SUBJECT_SAMPLE_FACTORS           	1577	F_1577_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=3; NMR_ID=161
SUBJECT_SAMPLE_FACTORS           	1616	M_1616-10_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=3; NMR_ID=162
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_140	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=140; Batch=3; NMR_ID=164
SUBJECT_SAMPLE_FACTORS           	1616	M_1616-10_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=3; NMR_ID=165
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_144	Treatment:Control | Source:Maternal	Gestational Age (days)=144; Batch=3; NMR_ID=166
SUBJECT_SAMPLE_FACTORS           	1577	M_1577_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=3; NMR_ID=167
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_146	Treatment:Control | Source:Maternal	Gestational Age (days)=146; Batch=3; NMR_ID=168
SUBJECT_SAMPLE_FACTORS           	1577	F_1577_120	Treatment:Control | Source:Fetal	Gestational Age (days)=120; Batch=3; NMR_ID=169
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_138	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=138; Batch=3; NMR_ID=170
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=3; NMR_ID=172
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_146	Treatment:Control | Source:Fetal	Gestational Age (days)=146; Batch=3; NMR_ID=173
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_142	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=142; Batch=3; NMR_ID=176
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_138	Treatment:Control | Source:Fetal	Gestational Age (days)=138; Batch=3; NMR_ID=178
SUBJECT_SAMPLE_FACTORS           	1577	M_1577_120	Treatment:Control | Source:Maternal	Gestational Age (days)=120; Batch=3; NMR_ID=179
SUBJECT_SAMPLE_FACTORS           	1577	F_1577_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=3; NMR_ID=180
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_140	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=140; Batch=3; NMR_ID=181
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_120	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=120; Batch=3; NMR_ID=182
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_138	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=138; Batch=3; NMR_ID=183
SUBJECT_SAMPLE_FACTORS           	1616-10	F_1616-10_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=3; NMR_ID=184
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=3; NMR_ID=185
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_148	Treatment:Control | Source:Fetal	Gestational Age (days)=148; Batch=3; NMR_ID=186
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=3; NMR_ID=188
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_143	Treatment:Control | Source:Fetal	Gestational Age (days)=143; Batch=3; NMR_ID=189
SUBJECT_SAMPLE_FACTORS           	1577	M_1577_140	Treatment:Control | Source:Maternal	Gestational Age (days)=140; Batch=3; NMR_ID=191
SUBJECT_SAMPLE_FACTORS           	1577	M_1577_138	Treatment:Control | Source:Maternal	Gestational Age (days)=138; Batch=3; NMR_ID=192
SUBJECT_SAMPLE_FACTORS           	1577	F_1577_138	Treatment:Control | Source:Fetal	Gestational Age (days)=138; Batch=3; NMR_ID=193
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_135	Treatment:Control | Source:Fetal	Gestational Age (days)=135; Batch=3; NMR_ID=194
SUBJECT_SAMPLE_FACTORS           	1616-10	F_1616-10_137	Treatment:Control | Source:Fetal	Gestational Age (days)=137; Batch=3; NMR_ID=196
SUBJECT_SAMPLE_FACTORS           	1577	M_1577_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=3; NMR_ID=197
SUBJECT_SAMPLE_FACTORS           	1616-10	F_1616-10_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=3; NMR_ID=198
SUBJECT_SAMPLE_FACTORS           	1577	M_1577_130	Treatment:Control | Source:Maternal	Gestational Age (days)=130; Batch=3; NMR_ID=199
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_142	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=142; Batch=3; NMR_ID=202
SUBJECT_SAMPLE_FACTORS           	1616-10	M_1616-10_137	Treatment:Control | Source:Maternal	Gestational Age (days)=137; Batch=3; NMR_ID=203
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_135	Treatment:Control | Source:Maternal	Gestational Age (days)=135; Batch=3; NMR_ID=204
SUBJECT_SAMPLE_FACTORS           	1616-10	F_1616-10_125	Treatment:Control | Source:Fetal	Gestational Age (days)=125; Batch=3; NMR_ID=205
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_150	Treatment:Control | Source:Fetal	Gestational Age (days)=150; Batch=3; NMR_ID=207
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_130	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=130; Batch=3; NMR_ID=208
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_149	Treatment:Control | Source:Fetal	Gestational Age (days)=149; Batch=3; NMR_ID=209
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_145	Treatment:Control | Source:Fetal	Gestational Age (days)=145; Batch=3; NMR_ID=211
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_125	Treatment:Control | Source:Fetal	Gestational Age (days)=125; Batch=3; NMR_ID=212
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_141	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=141; Batch=3; NMR_ID=213
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_130	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=130; Batch=3; NMR_ID=215
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_135	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=135; Batch=3; NMR_ID=216
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_149	Treatment:Control | Source:Maternal	Gestational Age (days)=149; Batch=3; NMR_ID=218
SUBJECT_SAMPLE_FACTORS           	1616-10	M_1616-10_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=3; NMR_ID=219
SUBJECT_SAMPLE_FACTORS           	1577	F_1577_125	Treatment:Control | Source:Fetal	Gestational Age (days)=125; Batch=3; NMR_ID=220
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_130	Treatment:Control | Source:Fetal	Gestational Age (days)=130; Batch=3; NMR_ID=221
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_143	Treatment:Control | Source:Maternal	Gestational Age (days)=143; Batch=3; NMR_ID=222
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_125	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=125; Batch=3; NMR_ID=223
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_125	Treatment:Control | Source:Maternal	Gestational Age (days)=125; Batch=3; NMR_ID=224
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_144	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=144; Batch=3; NMR_ID=225
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_120	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=120; Batch=3; NMR_ID=226
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_143	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=143; Batch=3; NMR_ID=227
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_142	Treatment:Control | Source:Fetal	Gestational Age (days)=142; Batch=3; NMR_ID=228
SUBJECT_SAMPLE_FACTORS           	1576	M_1576_144	Treatment:Cortisol | Source:Maternal	Gestational Age (days)=144; Batch=3; NMR_ID=229
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_142	Treatment:Control | Source:Maternal	Gestational Age (days)=142; Batch=3; NMR_ID=230
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_148	Treatment:Control | Source:Maternal	Gestational Age (days)=148; Batch=3; NMR_ID=231
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_135	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=135; Batch=3; NMR_ID=232
SUBJECT_SAMPLE_FACTORS           	1618	F_1618_141	Treatment:Control | Source:Fetal	Gestational Age (days)=141; Batch=3; NMR_ID=233
SUBJECT_SAMPLE_FACTORS           	1576	F_1576_143	Treatment:Cortisol | Source:Fetal	Gestational Age (days)=143; Batch=3; NMR_ID=234
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_145	Treatment:Control | Source:Maternal	Gestational Age (days)=145; Batch=3; NMR_ID=235
SUBJECT_SAMPLE_FACTORS           	1618	M_1618_147	Treatment:Control | Source:Maternal	Gestational Age (days)=147; Batch=3; NMR_ID=237
SUBJECT_SAMPLE_FACTORS           	1577	F_1577_140	Treatment:Control | Source:Fetal	Gestational Age (days)=140; Batch=3; NMR_ID=238
#COLLECTION
CO:COLLECTION_SUMMARY            	Blood samples were collected from ewe and fetus on gestational days 125, 130,
CO:COLLECTION_SUMMARY            	135, 138, 140, and every subsequent day until birth (control: 144±1; CORT:
CO:COLLECTION_SUMMARY            	142±2 days gestational age);
CO:SAMPLE_TYPE                   	Blood (serum)
CO:COLLECTION_METHOD             	samples for metabolomics analysis were collected in glass tubes on ice with no
CO:COLLECTION_METHOD             	anticoagulant and spun for 20 min at 4 °C; the resulting serum was stored at
CO:COLLECTION_METHOD             	-20 °C until metabolomic analysis.
CO:COLLECTION_LOCATION           	University of Florida
CO:STORAGE_CONDITIONS            	-20℃
CO:COLLECTION_VIALS              	Eppendorf tubes
CO:STORAGE_VIALS                 	Eppendorf tubes
#TREATMENT
TR:TREATMENT_SUMMARY             	The treatment protocol for this study was previous published in Antolic, A., et
TR:TREATMENT_SUMMARY             	al. (2018). "Chronic maternal hypercortisolemia in late gestation alters fetal
TR:TREATMENT_SUMMARY             	cardiac function at birth." Am J Physiol Regul Integr Comp Physiol 314(3):
TR:TREATMENT_SUMMARY             	R342-R352.
TR:TREATMENT_COMPOUND            	Hydrocortisone sodium succinate in sodium phosphate (Solu-Cortef; Pfizer, New
TR:TREATMENT_COMPOUND            	York, NY, USA)
TR:TREATMENT_DOSE                	1 mg/kg/day
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Saline buffer was created by weighing 9 g of NaCl into a 1 L volumetric flask.
SP:SAMPLEPREP_SUMMARY            	Next, 100 mL of D2O was added and filled up to 1 L with water and shaken until
SP:SAMPLEPREP_SUMMARY            	dissolved. Samples were thawed on ice and centrifuged at 3,000 g for 20 min at 4
SP:SAMPLEPREP_SUMMARY            	°C. Two hundred mL of serum was mixed with 400 mL of Saline buffer and
SP:SAMPLEPREP_SUMMARY            	centrifuged for 10 min at 3000 g at 4 °C. For each sample, 500 mL of the
SP:SAMPLEPREP_SUMMARY            	resulting supernatant was transferred into a 5 mm SampleJet NMR tube (Bruker
SP:SAMPLEPREP_SUMMARY            	Biospin, Billerica, MA, USA).
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	-
CH:INSTRUMENT_NAME               	-
CH:COLUMN_NAME                   	-
#ANALYSIS
AN:PROCESSING_PARAMETERS_FILE    	Serum_CORT_raw_data_cpmg.zip
AN:ANALYSIS_TYPE                 	NMR
#NMR
NM:INSTRUMENT_NAME               	Bruker Avance III
NM:INSTRUMENT_TYPE               	FT-NMR
NM:NMR_EXPERIMENT_TYPE           	1D-1H
NM:FIELD_FREQUENCY_LOCK          	H2O+D2O
NM:SPECTROMETER_FREQUENCY        	600 MHz
NM:NMR_PROBE                     	5mm Cryoprobe
NM:NMR_SOLVENT                   	D2O
NM:NMR_TUBE_SIZE                 	5mm
NM:SHIMMING_METHOD               	Topshim
NM:PULSE_SEQUENCE                	cpmgpr1d
NM:WATER_SUPPRESSION             	Presaturation
NM:POWER_LEVEL                   	7.37 W
NM:RECEIVER_GAIN                 	64
NM:OFFSET_FREQUENCY              	2824.2
NM:PRESATURATION_POWER_LEVEL     	6.41E-05
NM:TEMPERATURE                   	4C
NM:NUMBER_OF_SCANS               	128
NM:DUMMY_SCANS                   	16
NM:ACQUISITION_TIME              	1.8173
NM:RELAXATION_DELAY              	4 sec
NM:SPECTRAL_WIDTH                	15.0182 ppm
NM:NUM_DATA_POINTS_ACQUIRED      	32764
NM:REAL_DATA_POINTS              	65536
NM:LINE_BROADENING               	1
#NMR_METABOLITE_DATA
NMR_METABOLITE_DATA:UNITS        	Area under curve
NMR_METABOLITE_DATA_START
Samples	M_728_140	M_770_130	M_734_140	M_759_135	M_770_140	M_734_125	M_759_130	M_759_138	M_706_140	M_728_147	M_770_138	M_759_147	M_734_135	M_734_144	M_729_130	M_728_135	M_759_145	M_728_130	M_706_142	M_706_130	M_734_142	M_706_135	M_734_143	M_728_142	M_728_138	M_728_146	M_734_130	M_734_138	M_706_138	M_770_135	M_759_146	M_759_142	M_759_144	M_729_125	M_759_125	M_770_125	M_728_144	M_759_140	M_729_135	M_753_143	M_753_140	M_753_135	M_802_142	M_767_125	M_767_138	M_753_125	M_802_130	M_802_135	M_767_135	M_802_125	M_767_130	M_802_140	M_802_138	M_802_147	M_802_144	M_753_138	M_753_130	M_1618_141	M_1618_130	M_1616-10_140	M_1576_140	M_1616-10_130	M_1618_144	M_1577_135	M_1618_146	M_1618_138	M_1577_120	M_1576_138	M_1618_140	M_1577_140	M_1577_138	M_1577_125	M_1577_130	M_1576_142	M_1616-10_137	M_1618_135	M_1576_130	M_1576_141	M_1576_135	M_1618_149	M_1616-10_125	M_1618_143	M_1576_125	M_1618_125	M_1576_120	M_1576_143	M_1576_144	M_1618_142	M_1618_148	M_1618_145	M_1618_147
Factors	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Cortisol | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal	Treatment:Control | Source:Maternal
Very low density lipoprotein	10.20630041	11.23515801	15.14500904	8.54041087	12.74698309	17.13115572	8.096229699	10.95644904	11.57979169	12.10935075	13.00635895	12.03610108	13.35579588	14.5073767	14.22998862	12.22462891	12.1225597	10.3394707	12.56085689	12.16819064	10.29480041	10.2431654	13.29695599	11.33722722	10.60653178	12.85025311	14.13152186	12.56325851	12.01928968	12.8238352	11.42608747	12.11535482	12.48400478	17.30047052	10.86842936	15.91473094	11.73829916	11.53776319	16.85496846	16.14330106	17.92486791	14.80430862	9.527121173	14.96002924	11.58232603	14.93953968	10.13064103	11.52085736	11.48602512	10.03024221	12.74408382	9.943161596	11.56286095	13.27168987	10.92358682	14.33714675	13.18358478	13.11377093	14.43861431	11.34673732	12.06011453	11.80533695	10.70245234	13.31845664	10.18944258	9.167482236	13.41000384	12.11279735	10.88641038	14.790121	12.24666353	12.66898974	12.25098179	14.2814295	10.7819084	13.26577382	12.90908522	12.30193731	14.62602697	21.56115887	11.55142303	12.9971778	11.93747583	10.11171383	12.45825846	14.31511196	11.60842412	11.86320169	17.49076327	9.4518831	11.01768561
Isoleucine	0.707298144	0.779799988	0.499176866	0.674660537	0.695793953	0.692515117	0.463137938	0.595167611	0.896283457	0.666482291	0.740811992	0.671221528	0.540718208	0.602045629	0.457155004	0.682669187	0.550696045	0.947746105	0.838715391	0.776935717	0.744646722	0.982381164	0.696981117	0.896010221	0.700005561	0.697555856	0.628898164	0.475998888	0.766006265	0.377586704	0.598568933	0.519141961	0.589514446	0.608000297	0.675310651	0.720686723	0.785453153	0.544185483	0.472776584	0.765684168	0.896776543	0.524929813	0.695639065	0.429726013	0.631098344	0.840220847	0.688329245	0.629821328	0.571651013	0.676410422	0.622379402	0.525663731	0.526911391	0.888130993	0.649974707	0.693804271	0.75282593	0.561312757	0.848205326	0.650112616	0.628894045	0.71952646	0.779172877	0.538345351	0.783368219	0.661759109	0.600410369	0.82793559	1.097107258	0.666345148	0.523954676	0.516112828	0.845079749	0.535154658	0.636028917	0.728996212	0.609973145	0.65186145	0.585284812	0.422540883	0.871591335	0.730782256	0.617163831	0.841926266	0.56507089	0.568373211	0.650391685	0.7575264	0.523229096	0.833935581	0.612103374
Valine	1.113530475	1.768364651	1.039778914	1.299889975	1.162404336	1.132603759	1.149330091	1.072155414	1.741575044	0.723043323	1.49451533	0.969874066	0.988203195	1.343279981	0.960016864	0.963932268	0.880071638	1.533783857	1.214312062	1.507681162	1.52657127	2.423908638	1.605909723	1.372702755	0.984001577	0.837047986	1.627547483	1.112500105	1.773630985	1.11111483	0.91211613	0.953926236	1.093598549	0.923392952	1.307217048	1.448835614	1.032291562	0.818924931	0.838891203	1.339232977	1.573463542	1.238142095	0.986466208	0.897284797	0.825351587	1.590383205	1.458311269	0.849844032	0.901851463	1.253271231	1.017512969	0.950228559	0.792465018	1.814609813	1.395757795	1.283792333	1.446483931	1.495624412	1.889381289	1.436860695	0.978743556	1.977167087	1.486909792	1.164229029	1.466762232	1.388650462	1.208441731	0.938048683	2.174405303	1.226190772	1.204204347	1.086596963	1.262248508	0.857778245	1.790562304	1.566540625	0.974666074	1.077002887	0.929653866	0.822919768	2.282738414	1.462844651	0.854180467	1.517370984	1.057974635	0.907827343	0.848583922	1.519449701	1.016080503	1.596921866	1.202365482
BCAA	9.917645503	11.88377272	10.18131397	10.21478697	10.06104896	14.77653502	9.386924681	9.500970668	14.22413906	9.355463718	10.85123126	8.741243307	10.2632588	10.8896429	10.52747601	10.15479165	8.803799407	11.65604657	13.09739763	11.80694944	11.00396326	15.49172317	11.78317081	11.66702133	9.963922384	9.440243695	14.30827884	10.37584149	13.65802465	10.00818723	9.148223776	9.296931696	9.927065501	12.12979013	11.40820004	12.9675297	10.42074653	8.737950881	10.67472063	11.3227174	12.04761688	10.86351812	9.032785919	12.82594521	10.2243936	13.05987692	11.20575154	9.43494629	9.19884855	14.01437604	11.88733034	8.693584946	8.400448302	12.49381995	10.83174962	10.56749343	11.7140476	11.71085032	13.93036269	10.96332623	9.32002233	13.51912837	11.27751695	11.003681	10.78557308	10.86628262	9.796881201	9.786312095	14.80663771	11.74255764	10.89991159	9.000258815	10.54440528	8.516097652	12.1585961	11.64455319	10.3070808	9.660443644	9.9554178	13.78143437	15.43597996	11.58786435	10.70102023	11.86170029	10.85955682	8.705861156	9.426001644	11.90782003	13.06081347	11.34957904	11.71757611
3-Hydroxyisobutyrate	0.074827248	0.11912865	0.165573993	0.120424659	0.116144816	0.188409871	0.177730356	0.119942424	0.107240532	0.206604229	0.095688973	0.078456073	0.133445028	0.318452811	0.198717663	0.097936393	0.116687331	0.42452461	0.191172681	0.148705784	0.21182845	0.120806429	0.211386401	0.072416069	0.09431661	0.066225366	0.117410685	0.133213957	0.103262086	0.057661661	0.122062252	0.096128009	0.119098511	0.180613724	0.082430501	0.114989459	0.063532882	0.164900872	0.05867737	0.076710495	0.06861656	0.060392516	0.244587074	0.141829421	0.229088355	0.133150711	0.210086696	0.195259969	0.066151635	0.123914389	0.101767234	0.233120309	0.195016908	0.188311282	0.145446742	0.040335687	0.067682919	0.103678646	0.104573865	0.091061365	0.121131	0.090820276	0.126635272	0.141738783	0.135419063	0.177981889	0.234593462	0.095816666	0.106718848	0.086618061	0.106514986	0.236038223	0.081030471	0.090176781	0.087070102	0.130863192	0.1178958	0.083444905	0.146117382	0.396060978	0.085187482	0.090155509	0.119163289	0.087448577	0.097926194	0.106452941	0.15994454	0.076854847	0.34142598	0.143387405	0.149662807
Lactate	6.138072291	5.496996081	16.43150577	4.872086891	8.15104584	6.188657098	7.063041361	6.054937884	6.480022714	11.2968604	6.807674308	7.353257322	7.922695673	30.37106916	8.348499037	8.269244715	7.099686605	8.240862615	9.158143369	9.133210232	30.34951314	6.268270687	38.66367232	5.78505644	5.982437784	7.931964764	5.348690623	8.040607134	6.336100315	7.715901531	7.805574599	6.51250046	6.513147141	7.245908314	6.110624284	6.957919808	7.736523463	6.439569239	9.697403283	8.666610799	4.398061613	4.366411048	16.46856064	6.08820179	11.13244645	2.230596698	13.75174457	11.0229526	9.094321139	15.57379061	7.258246194	18.32995604	21.26233812	4.797714154	4.749810596	6.97014051	3.863423689	6.295417216	7.109128963	5.993245885	13.98702375	3.820891214	8.201247447	7.756187732	9.436404725	7.535989211	11.47188736	18.13529917	6.357385652	4.584065596	5.079061041	11.25123762	8.251483995	12.27567213	2.913925994	7.319550911	6.963834038	8.203353171	14.06674043	13.92385204	3.865412226	5.944062199	7.986012418	8.347294417	8.232081257	14.61573264	17.13808865	6.563746561	15.60542272	8.238398427	14.1599939
Alanine	1.803374329	1.307623012	1.866276323	1.342657034	1.278859284	1.372814161	1.549775784	1.530865374	1.75709359	1.569482421	1.336486269	1.511457322	1.486077562	2.46623395	1.115234477	2.015369974	1.364752355	1.922609438	1.491253042	1.743557718	2.419555097	1.534846513	2.430204643	1.720068999	1.837114481	1.540021993	1.496528051	1.469655364	1.63984905	1.25049367	1.629299033	1.433626057	1.539922465	1.263531899	1.368733494	1.166790225	1.672792975	1.342059863	1.655873134	1.539780473	1.479896341	1.207429181	2.168281915	1.122847074	1.569553375	1.131079733	1.740634783	1.73341711	1.248592473	1.959194947	1.524894022	2.06464064	1.803338318	1.90968622	1.984682355	1.311747113	1.271937135	1.55004193	1.259576644	1.687361407	2.088516237	1.457737464	1.543502907	1.21351918	1.616853684	1.278246028	1.54577735	2.440201938	1.387040203	1.214561633	1.277772186	1.401445007	1.344394403	1.820511073	1.637418436	1.211908116	1.531088241	1.851879428	2.059232787	1.557244331	1.254743454	1.528908566	1.541702306	1.489105819	1.438309932	1.844582258	2.14499823	1.543976749	1.100555193	1.558002479	1.585295791
Arginine	0.126319758	0.109276644	0.104842002	0.152132805	0.102394369	0.241159819	0.138621147	0.134340047	0.179092899	0.101753107	0.110197894	0.075912965	0.146325321	0.095810146	0.19286648	0.120954835	0.14378737	0.105492296	0.196614701	0.18936212	0.063614285	0.15740741	0.078595426	0.163278117	0.143091917	0.101608598	0.24009406	0.15497784	0.179020644	0.141719074	0.13946111	0.200073902	0.155032032	0.280502588	0.163034257	0.16144465	0.133870391	0.157073231	0.139108868	0.061560378	0.141841288	0.181282772	0.106403281	0.213753088	0.120680579	0.173631792	0.140456943	0.161147963	0.031853808	0.161765974	0.211182161	0.116539903	0.127515785	0.150357484	0.160196225	0.108388334	0.128121436	0.134958714	0.090393209	0.15035008	0.143364071	0.128737743	0.094402614	0.209419105	0.095143494	0.089150021	0.17470045	0.123629098	0.101367484	0.228051818	0.209429171	0.155836211	0.191662159	0.124612575	0.171076583	0.108915193	0.157869603	0.17081486	0.139569077	0.216344716	0.129291389	0.112874267	0.131274449	0.073039921	0.207456177	0.129482649	0.100665864	0.090791834	0.044033889	0.106836503	0.126090307
Acetate	8.478968488	11.8752671	9.951304966	9.153337475	8.429651866	6.6985566	11.40461055	10.15123168	6.633073949	4.149644415	9.571403274	13.01712083	10.93906983	8.277404703	11.08026679	5.504214438	10.47864494	8.34667307	4.188729372	5.597527216	12.8442057	6.718406029	13.85611729	7.507165022	7.163892688	9.840393726	8.438860364	8.52644341	6.126094988	9.104225487	10.51445576	9.106169503	11.95712042	10.61165657	9.377717871	6.060714654	8.606455024	10.44692678	7.713640005	7.383248826	12.10034669	11.80289002	8.291239481	4.419899017	5.003096895	9.908473203	8.509512857	7.496498393	10.72024743	8.989514872	9.500259615	9.58775176	9.182197003	7.046906753	7.090362016	14.03963127	13.62169633	6.038042351	10.28894576	7.322985338	9.118573345	6.492321681	8.460144194	7.998616302	8.53057426	9.402998293	13.11134137	10.87186004	9.637548802	8.442076881	8.430500818	12.82572636	11.70814944	10.09648019	6.805740881	8.739808893	8.844534397	9.776136995	8.464471695	3.812192641	5.104492378	7.787217919	8.02685324	9.566036862	7.500737408	12.99558074	8.605872762	8.186646184	8.925783212	10.70525128	7.950364675
N-acetyl-glycoproteins	13.95677716	15.06049201	13.98110755	13.71236736	12.7778593	17.27455727	13.74775702	13.50555907	18.32297578	14.00764979	13.34298784	12.84974453	13.27773817	13.19147588	15.12352983	14.83488296	12.34654788	14.12156024	16.48934931	12.86743936	11.44521762	17.48136556	13.33635228	13.73006219	13.45689829	13.10631953	15.16223727	13.50666499	17.27123949	13.84065486	11.99375727	12.22268409	12.9105705	16.12328757	15.2296988	16.98038077	13.25119593	12.44386943	15.13348317	14.19969387	13.31924885	15.20041828	11.86627399	15.72483635	15.2982455	15.46342918	13.14604655	12.49493419	13.90460847	17.68138086	13.8805526	12.35541012	12.93916602	14.65354805	12.37625854	15.2597561	14.73213057	14.48681879	15.09622093	12.98668888	11.803973	13.30164234	13.47060175	15.05111041	12.27394263	14.01848955	11.53659064	13.80031866	15.13476993	15.27092168	14.89281349	12.30921085	13.82246383	12.51425868	13.73470335	13.5411382	15.57521266	12.8997486	14.05949911	18.56070904	14.01684917	13.523094	17.79875131	14.16694418	15.53256271	12.58561533	13.25571163	13.8815176	20.20437243	12.63154604	15.43824071
Methionine	0.406584769	0.450763644	0.339706892	0.443727534	0.385522882	0.442496795	0.430642227	0.419147592	0.419879069	0.333437091	0.391815904	0.355822603	0.364460995	0.348322063	0.317646482	0.404425171	0.34952958	0.460481835	0.393069864	0.39549651	0.385279056	0.43287149	0.428935448	0.412401751	0.366713479	0.371531937	0.451901496	0.312421648	0.470478684	0.343306222	0.362580055	0.34781119	0.388506843	0.372855562	0.46321036	0.42271209	0.355567166	0.337361522	0.34107696	0.401342554	0.398945482	0.320505137	0.389775408	0.388908382	0.479619694	0.431729262	0.412144677	0.368395569	0.432208677	0.40454545	0.411022643	0.29284191	0.380615534	0.506558699	0.381625364	0.355226975	0.410492227	0.332442119	0.467407653	0.402206997	0.335792732	0.419901051	0.391557146	0.330102845	0.401195657	0.41306791	0.40138913	0.435299803	0.431931601	0.427569647	0.346530526	0.338501365	0.363635365	0.373115579	0.425485407	0.472965626	0.433866339	0.430163955	0.354295859	0.330428233	0.422759186	0.440549978	0.412874436	0.40347337	0.359730713	0.359458091	0.439907997	0.493025337	0.343338209	0.384011669	0.318978104
Acetone	0.615010713	0.71329928	0.743579283	0.499881931	0.619982768	0.570157446	0.838057846	0.587988263	0.584816435	1.596972453	0.647071893	0.636956333	1.119483758	1.117864507	1.141486529	0.512369217	0.759809898	0.564261466	1.008403105	0.327431645	1.009184155	0.357397323	0.978456477	0.440579225	0.585387935	0.812197447	0.56318514	0.675580244	0.500462956	0.638080284	0.649967496	0.769668282	0.900037079	1.44304831	0.733578024	0.421005332	0.670236714	0.923897226	0.75707622	0.821224623	0.663085058	0.799057989	0.468740599	1.232562059	1.499961851	0.724857047	0.441636934	0.781846571	1.120546913	0.799267108	0.466594854	0.935612817	0.97716389	0.407623244	0.487715892	0.900480794	0.600612975	0.553346766	0.690135738	1.083192597	0.510379169	1.006857014	0.862478419	0.989612861	0.553764141	0.71129003	1.196432865	0.613679336	0.653000399	0.528172499	1.15952818	1.035084705	0.815677567	0.694968494	1.058369803	0.754114841	0.776718961	0.370778412	0.839105452	1.502983386	0.358399966	0.610581978	0.819302134	0.573962866	0.805473861	0.637195089	0.606759707	0.681217106	0.839687579	0.692288511	0.877712585
3-Hydroxybutyrate	1.744190642	1.652207346	2.392527445	1.490873009	1.923976173	2.254098039	2.009415203	2.082220162	1.949153419	2.930429759	1.813541683	1.670658541	2.693654577	3.39861746	2.686655848	1.616395668	2.024139801	1.801180292	3.106125124	1.446790106	2.548771797	1.620304049	3.268641065	1.819358809	1.849353362	2.238010052	2.40007153	2.167659192	1.792545496	2.18974609	2.230647753	2.053861676	2.190655016	3.499871799	2.181202187	1.560405836	2.041954748	2.437064811	2.832811123	2.425398131	2.190972423	2.524033221	1.473190141	3.137043615	3.06775358	2.180037764	1.362169875	2.007649512	2.547464634	2.52291744	1.95810881	2.249327799	2.593881148	1.38303499	1.29890506	2.450726372	2.041792428	1.846070893	1.86252787	1.876589211	2.003037123	1.749308035	1.870443884	2.495600694	1.751495355	1.995225267	2.542680147	2.203958064	1.893462821	2.214894662	2.274264769	2.205937067	2.291138378	1.864819348	1.586196478	1.831072129	2.256766211	1.859194812	2.433105844	4.316075654	1.571718505	1.771181232	2.316865425	1.767327383	2.150629126	2.054387058	2.261453325	1.757848998	3.13179826	1.859090653	2.175939539
Citrate	1.248156591	0.322443599	1.223934999	1.349097678	1.664191789	0.300131991	1.439155053	1.694708861	1.215505458	1.035454729	1.106028127	1.588325919	1.253171635	1.677743076	0.542678697	1.075916526	1.475327388	0.52459253	1.169516442	0.343517452	1.322101806	0.195627022	1.13761223	1.512353346	1.406824029	1.553434021	0.919265776	1.166422054	0.583375241	0.374973511	1.564104326	1.332772111	1.605718516	0.207855192	0.27457661	0.171853583	1.445984048	1.331918487	0.436370447	1.351900219	1.007042499	1.321090046	1.736216581	-0.279998402	0.768263663	0.530309133	1.60135451	1.388115685	0.753939635	1.163120346	1.210822061	1.734865257	1.676893485	0.7721825	1.207849149	1.009204617	1.177444374	1.073341457	1.022927299	1.286040949	1.232458194	1.582205885	1.594313526	0.28236898	1.685249643	1.218547287	0.938414243	1.329834546	0.362837569	0.386760895	0.424612302	0.513083956	0.39248841	1.700448598	1.001545719	1.274019177	0.504977847	1.569325415	0.760749629	0.44585649	1.275049615	1.256931087	0.305553826	1.360232455	0.505458717	1.975575433	1.881805612	1.277368099	0.475953855	1.303815997	0.29123933
Dimethylamine	0.783372844	0.538211835	0.967375024	0.574306058	0.659735995	0.869754979	0.56668848	0.67101358	0.546622909	0.628224221	0.612314594	0.560310743	0.886081192	0.821867397	0.827868223	0.791734325	0.612393944	0.6914759	0.573958902	0.62032892	0.804013701	0.43206169	0.876321171	0.842418986	0.680198315	0.727351912	1.054620087	0.958269638	0.470675268	0.545293801	0.610965648	0.594480735	0.66543926	0.87539873	0.522847737	0.471399335	0.805213866	0.631437886	0.85501576	0.63509907	0.612323441	0.449448631	0.798956303	0.696064698	0.642681722	0.375683818	0.732372871	0.806359075	0.709873981	0.870092094	0.737783121	0.809389368	0.805860945	0.731819393	0.771683663	0.523282628	0.423462828	0.72013274	0.832487788	0.736605512	0.61684667	0.848378642	0.765504484	0.805146568	0.688870284	0.686220316	0.924207108	0.713310864	0.826310499	0.862881843	0.880518452	0.772451697	0.871744911	0.646461849	1.058227433	0.806865466	0.665450299	0.614420517	0.631493112	0.586604809	0.868880081	0.728378079	0.606014031	0.969865335	0.555986939	0.711153289	0.566130228	0.774206405	0.552943057	0.90522761	0.486434241
Creatine	3.068390958	2.995011176	2.609599459	2.475405584	2.717223139	2.27186062	2.530944007	2.658423393	2.845949502	3.717394362	2.646529153	2.712331154	2.562310267	2.814295478	2.3465833	3.085464947	2.523174383	3.096879579	2.131144097	2.446149592	2.453247767	3.320184327	2.682307792	3.163353029	2.745711761	3.05285171	2.440298394	2.577753593	2.567681858	2.638375844	2.858611111	2.38245786	2.54091982	2.150807961	2.641829011	3.157789594	3.188580326	2.705904428	2.77784539	2.936614629	2.607112351	2.891225176	3.17419469	2.918664644	3.261200669	2.435272683	1.870476967	2.690116742	3.101708762	3.105138695	2.847779352	2.850065974	2.573270341	2.320026917	2.951134681	2.789927807	2.581959506	2.174137699	2.488138167	2.792794542	2.664897265	2.801165292	2.649421111	2.272542681	2.43596698	2.862096567	2.818490798	3.69712757	2.40297065	2.70276031	2.258234539	2.935681302	2.635891642	2.845744404	2.719015139	2.357612864	2.752984811	2.894508891	2.865892605	2.163333591	2.928381229	2.568633637	3.024158185	2.589463179	2.736535314	3.109033699	3.523580504	2.606594016	2.600656624	2.619539479	2.398298604
Dimethylsulfone	0.477112534	0.71669086	0.316871425	0.483308829	0.509335027	0.398541053	0.833549105	0.47403199	0.333391944	0.236997314	0.701217726	0.74391407	0.590397348	0.28599557	0.596928102	0.344675537	0.684221924	0.386403709	0.230660194	1.003366306	0.378464707	0.475994737	0.502760266	0.425993103	0.33784553	0.364971923	0.68765453	0.463989416	0.40797632	0.651620964	0.549179666	0.483942541	0.618104643	0.311810531	0.479339328	0.47838876	0.388604098	0.43435458	0.2567304	0.260216606	0.359792632	0.519406432	0.419021533	0.417476221	0.26866753	0.543443274	0.595090489	0.497627195	0.754293817	0.367965882	0.953868414	0.432386065	0.627264363	0.542272217	0.351486581	0.443263611	0.427496602	0.808555829	0.495505737	0.845267009	0.500404088	0.430843278	0.476473053	0.400225942	0.493347501	0.570377501	0.418740226	0.47397627	0.6427948	0.379902548	0.522250943	0.388948098	0.579264358	0.4194279	0.578989288	0.566568849	0.390958221	0.585114871	0.363207954	0.215231217	0.759688699	0.648634734	0.536046729	0.361092036	0.469130817	0.493040692	0.467639095	0.675686748	0.37442232	0.547726597	0.331299908
Choline	12.42139726	14.38396056	14.37620339	9.441315262	13.08408097	12.50561793	10.78906765	10.70373881	10.71925315	10.63946514	13.65811134	13.18714048	13.31679599	14.5025344	11.64235604	12.21084558	12.35601542	11.73655021	11.12262584	10.11197777	11.89834256	11.84515056	15.23946528	10.81123099	11.4838882	11.76757888	10.84004332	14.20997838	11.91607323	13.37663699	10.78574315	11.32763669	11.66784388	13.85868952	10.66716931	15.03667077	11.25560585	10.59403031	17.57658894	15.44789353	16.11949656	14.16047894	9.748425984	12.69200523	10.34560529	13.06991352	10.85193924	11.51301558	12.83937893	10.43929286	11.5603857	10.27612912	11.61301916	12.16672323	10.46982027	14.7520791	12.63516108	13.03249563	14.22767503	12.76709946	10.89946353	11.90097545	11.22224267	12.12692084	11.13437501	10.79725014	14.25278007	12.02739728	12.10719545	12.82179259	12.60033024	13.94793311	13.26202746	12.38693737	13.76323172	13.76861137	11.01153962	11.2052071	11.86869754	16.95964173	13.0396685	11.6687538	11.05457684	10.87794493	10.28528657	12.9051772	11.67592667	12.48735754	17.53526452	10.54619971	8.682867507
Betaine	8.240872998	8.885708728	11.3941124	11.00593447	8.199439451	7.914426871	15.20055794	9.527510184	6.533099383	8.904856049	9.175115775	14.39909084	10.92118403	8.635747255	6.752927367	7.18818887	12.76999912	8.778567436	7.41178354	8.859237296	8.931850633	6.870950198	7.951989102	7.779453953	6.935088491	10.00462375	7.468388462	10.65960861	7.466295858	9.253379142	10.49115404	13.77444874	10.92327664	8.380449643	9.843493294	8.707628181	10.37710715	10.95780459	7.432604944	8.079208203	9.041093596	7.981204251	12.26643062	8.499731675	11.08669563	7.902914552	6.525611537	12.44371708	7.792571462	7.662372289	8.820974733	11.10896281	12.46640974	6.607730623	6.247200888	9.520618	8.811472179	12.06552383	10.56047377	12.41874108	6.281548373	12.03192512	9.81018865	9.949924838	11.30222998	12.26108558	13.58866551	7.528491398	10.7861882	9.73006864	10.75862003	10.52945957	10.85597015	5.735784654	9.436812177	11.02568672	6.434379444	5.804877394	6.921043887	8.72925773	9.851885515	8.599170403	8.322799446	10.0304756	6.297227773	5.474317743	5.736560009	9.62462037	8.712802975	10.2667004	8.089762215
Scyllo-inositol	0.451713966	0.270734128	0.07488361	0.237541392	0.115862007	0.264814617	0.230969732	0.340296738	-0.010880567	0.290766822	0.323508069	0.393087401	0.039873216	0.039826395	1.571504767	0.350597355	0.706035537	0.322638537	0.088781082	0.357269346	0.259948579	0.282974472	0.192492914	0.103424346	0.352319698	0.227625376	0.531493584	0.040570515	0.309210946	0.282272157	0.19152305	0.304528848	0.341283323	0.301936972	0.55211154	0.220317957	0.093969851	0.138195618	0.240250321	0.050727346	0.434449814	0.101627446	0.077435013	0.233888034	0.164745605	0.269741234	0.514462628	0.378127235	0.297478726	0.086338981	0.143952021	0.128063883	0.685252691	0.244461761	0.547052593	0.470938709	0.383467073	0.290839306	0.037964543	0.09290147	0.889876565	0.152664013	-0.017316233	0.282813082	0.087691836	-0.009206641	0.391968315	1.082873014	0.03115743	0.042314376	0.048718413	0.221638713	0.344474529	0.996186971	0.098788779	0.022288347	0.932513673	0.927713469	0.994916329	0.008537173	0.093910925	0.010357722	1.217419916	-0.003462631	0.690173948	0.673817958	0.770718552	0.034798526	0.013267492	0.004831133	0.099861766
Glycine	3.971791359	3.098061152	3.66706951	3.471714948	3.914300693	3.138425427	3.67552611	3.613771612	4.742478963	4.409473697	2.973628326	3.568717123	3.558981373	3.440731104	2.510718317	3.968024974	3.426944714	3.32240977	2.868027425	2.800161435	2.984430034	4.011587123	2.896666162	3.948127092	4.111787171	3.950827519	2.34322079	16.30520919	4.053443738	1.861834176	4.93939693	3.874504929	2.812171228	2.552574933	3.33932297	2.966166621	4.25100128	3.465958776	2.805988671	-0.176594786	3.180740863	2.943499503	4.295215126	6.24789401	5.330548707	3.084434964	3.051730709	3.59975283	3.88072032	0.621316748	4.451147565	5.399209572	3.568313381	3.860302747	4.883891706	3.170261046	3.370642362	5.217377223	2.833235723	5.651497175	3.285099831	6.050128815	4.251697427	2.754763723	3.505372111	3.799374418	2.529290569	2.376629642	2.921191668	2.391620394	4.436328429	2.508334109	2.005379069	3.436384057	5.54304367	2.925015839	3.045094825	2.793770272	3.300090583	3.180623465	4.648493465	4.482524421	3.222230451	3.876622683	3.553403705	3.045400759	2.83920143	5.021273706	2.763788767	2.917520463	1.783730087
Creatinine	0.429323256	0.358689489	0.285507306	0.334135012	0.360723846	0.296138464	0.361806649	0.359662918	0.273858969	0.503194495	0.245902959	0.28966352	0.293305676	0.337120924	0.305883693	0.4444825	0.320572629	0.357311376	0.336880301	0.279622982	0.334911568	0.290636949	0.307928988	0.477130657	0.469386974	0.477097845	0.210192329	0.265349667	0.30075405	0.336158433	0.332056905	0.365120683	0.364573813	0.325155402	0.289040088	0.390911086	0.480269692	0.347336461	0.375697155	0.397387422	0.278290907	0.274604521	0.384284872	0.522503653	0.376704999	0.223685446	0.28366171	0.337659677	0.414963339	0.323397366	0.351052167	0.324474288	0.383787831	0.341663618	0.315334259	0.351576822	0.254612433	0.299540762	0.297920966	0.290699378	0.447018089	0.272130783	0.390586772	0.228818124	0.364695352	0.330907429	0.258733724	0.52125872	0.391270124	0.246644312	0.2334666	0.255603806	0.282203887	0.435283007	0.311621737	0.278289381	0.377215022	0.424914628	0.363202103	0.261492438	0.267465435	0.296174624	0.429824633	0.354521011	0.362763409	0.404388781	0.492051781	0.292285427	0.403308917	0.367909634	0.375941121
Glucose	5.560652477	5.726080646	5.608318221	4.33834724	6.437901145	5.486847455	4.856881791	4.441004962	6.537574104	6.580988823	5.389978363	9.740675899	6.068695138	5.614378192	4.931953077	6.069056927	5.928411327	5.171638505	7.205979883	4.45936577	4.643245195	6.270483134	5.308937554	5.907789335	5.745165033	6.056665643	6.488642098	5.992538485	5.822045265	5.589595623	5.977976464	5.412590196	5.379848262	4.838701878	5.095572299	4.922365659	6.284773813	4.436482595	7.773627335	5.008412089	4.698054367	5.936693012	5.801688101	4.115592642	5.995330098	4.900212703	6.19190395	5.886013816	7.453020144	7.926444811	5.303831315	5.897880845	6.815551248	5.499707106	5.478486065	5.454193558	5.077101247	5.11232312	5.481394329	5.995457798	5.583914109	4.685059731	4.883948105	5.206641318	4.958836363	8.680011471	5.314726457	5.369501311	5.194338944	5.176275935	6.0369539	5.352414681	4.886681966	5.95425461	5.716311082	5.058524645	5.228121653	5.641715737	5.174811367	7.530813554	5.130093215	5.045929357	5.3857092	5.21113266	5.445951776	6.115747673	6.120824844	4.778010999	9.168396177	5.052178182	5.298030379
Tyrosine	0.268447222	0.2450781	0.108697664	0.313465125	0.200115248	0.308427964	0.348904165	0.252537502	0.232581537	0.145133126	0.270167564	0.282375109	0.136421315	0.213699066	0.209432619	0.25640483	0.257381984	0.255455201	0.202716405	0.323071513	0.24377064	0.237935241	0.199743654	0.234246828	0.235072592	0.194445002	0.242119112	0.174186257	0.305510265	0.13448077	0.232884318	0.22187413	0.178810536	0.218708702	0.26259806	0.290219867	0.1862837	0.167731535	0.060635444	0.178443485	0.238513366	0.146400966	0.232624471	0.226263204	0.209619989	0.301149798	0.340844732	0.227365404	0.188930127	0.19809413	0.254857413	0.134953835	0.158966042	0.33802625	0.265202344	0.145519206	0.246559424	0.191002267	0.386656183	0.185931064	0.18633616	0.222074639	0.271031253	0.168324387	0.368284325	0.240123921	0.215345542	0.303101361	0.431974434	0.221084404	0.188796744	0.196673613	0.299898101	0.18578853	0.225713002	0.271653901	0.18844416	0.1881891	0.165901312	0.138422293	0.227468418	0.237813372	0.181932615	0.342050601	0.144836315	0.169209597	0.224070112	0.291098514	0.359822317	0.342898302	0.273334299
Anserine	0.291157399	0.266307798	0.322209375	0.18793598	0.351376577	0.659650647	0.143155903	0.299418321	0.347379788	0.359343421	0.353221249	0.132408684	0.305366719	0.254424369	0.458822027	0.317370453	0.37345917	0.219509276	0.346551022	0.36086728	0.223947182	0.290943524	0.18442041	0.317998711	0.340268444	0.239961072	0.470959433	0.365933444	0.388590826	0.341925976	0.304377547	0.284807985	0.27936754	0.503267924	0.207345136	0.584994907	0.314122226	0.318252687	0.195221097	0.166065311	0.349137985	0.342572577	0.168171196	0.523647757	0.381717272	0.443949284	0.192698568	0.405315576	0.182323985	0.233051049	0.46254611	0.209344354	0.317890361	0.313306963	0.409883489	0.301755562	0.400097316	0.357568117	0.320807486	0.273114723	0.372639823	0.319282782	0.194645795	0.437516008	0.094817279	0.234471082	0.301161666	0.0890866	0.080034733	0.35891748	0.374766786	0.287965347	0.07720107	0.409385206	0.278070013	0.29411753	0.434306505	0.363384865	0.426446652	0.640865875	0.277239049	0.396867381	0.367867497	0.084634844	0.498397467	0.361417996	0.321806168	0.358444822	0.287759512	0.078004513	0.493747118
Histidine	0.158652149	0.182300631	0.195135999	0.245240327	0.192471381	0.16757386	0.190175528	0.158901957	0.200691251	0.124678275	0.237686612	0.191519732	0.150872418	0.174532795	0.136157543	0.136871279	0.167419217	0.298461306	0.137668286	0.165456441	0.19564751	0.171880073	0.16873963	0.15981792	0.11839739	0.119313353	0.175841312	0.131768061	0.175484444	0.204033918	0.217012034	0.186690113	0.216191236	0.11644651	0.190080363	0.155392751	0.153965277	0.179231562	0.201357405	0.129196938	0.163462705	0.203588688	0.198859666	0.169982784	0.21241829	0.155434366	0.207485025	0.111757689	0.223997322	0.166840577	0.127814367	0.167500441	0.134522979	0.208349131	0.210328722	0.20863193	0.149762682	0.128782972	0.155617776	0.171712303	0.166628148	0.184239978	0.233635718	0.17662169	0.211479925	0.169456209	0.151661668	0.213910787	0.147681728	0.134359654	0.134963397	0.167621147	0.093563285	0.247648919	0.16681086	0.157365454	0.187759166	0.19371716	0.169511817	0.134534422	0.144782171	0.19115125	0.138101274	0.183167539	0.23381843	0.226708557	0.18016471	0.216921559	0.140810175	0.146116762	0.141223263
Phenylalanine	0.489277312	0.33269508	0.224742051	0.666090051	0.532074809	1.029469864	0.403568343	0.664456414	0.611173245	2.6073545	0.733259137	1.630496408	0.330425084	0.991763237	0.98103062	0.37295664	1.545015389	0.580884471	1.279454356	1.258274059	0.585462454	0.302653251	0.295130921	0.74256707	0.869981278	0.684781901	1.379657106	0.23060225	0.852144238	1.099849236	2.015445931	0.957380871	0.566238723	1.00885944	0.412239918	0.385227916	1.071165606	0.961939859	1.199102198	1.132579523	0.963362603	0.710592745	0.937172947	0.354397557	0.218528798	1.93598292	0.57543825	0.673006621	0.26259091	0.748051889	0.844112371	0.825239946	0.641134604	0.475346148	1.67456254	0.556676933	0.965648245	1.142621388	0.506321493	0.404520432	0.522479235	0.420568877	1.440911157	0.568493278	1.197269896	0.420486904	0.62711291	0.595662695	1.286711286	0.387369909	0.66972053	0.527106142	0.750563889	0.397907963	0.374354456	0.362222487	0.555751068	0.716326599	0.315106366	2.304995139	0.990152053	0.952717825	0.624608187	0.543418722	0.330799596	0.505629279	0.752139587	0.923417117	2.335051818	1.78373946	1.137976265
1-Methylhistidine	0.247909931	0.161650939	0.098234202	0.199419275	0.123609632	0.143864117	0.104305088	0.186589615	0.050565737	0.224718273	0.15752361	0.176031077	0.095984917	0.106608968	0.067682141	0.26553297	0.153767523	0.252659635	0.071147787	0.196809667	0.11290915	0.082500126	0.122037317	0.145119786	0.160406189	0.156846641	0.114383196	0.092534558	0.030908514	0.182254827	0.151321698	0.164937516	0.15972922	0.074619985	0.147205288	0.223615468	0.169872841	0.163594496	0.074224722	0.157269716	0.191937285	0.106061176	0.140104104	0.230316662	0.230088427	0.129088802	0.08287739	0.093364149	0.228418714	0.07044103	0.137473405	0.070807406	0.095826676	0.09755645	0.116908305	0.246389152	0.185522703	0.097539809	0.104476877	0.225892931	0.16657119	0.126556784	0.049028926	0.216251846	0.047451814	0.116835863	0.166562512	0.037590399	0.051734678	0.17180393	0.237824966	0.197299435	0.079056001	0.087227927	0.188925316	0.093799658	0.145362539	0.094827983	0.179414399	0.159733049	0.180950377	0.120644568	0.165052567	0.042549527	0.176142852	0.098637556	0.103315782	0.122929445	0.145327828	0.050753213	0.17844248
Formate	0.108351152	0.12608158	0.149257192	0.192293691	0.150905399	0.168730445	0.225120468	0.165342465	0.135975396	0.091061773	0.141611346	0.086056109	0.161450867	0.115609365	0.140833026	0.125968647	0.198810211	0.106846401	0.083889023	0.112019938	0.123876341	0.130139525	0.129197911	0.142816979	0.154522296	0.116889777	0.132089902	0.166746493	0.101923148	0.180206845	0.13579684	0.191072798	0.173064617	0.167738469	0.166944888	0.119549799	0.114077143	0.182770721	0.22006902	0.1287564	0.181004851	0.140068045	0.085055062	0.214553474	0.152381682	0.228207124	0.119798833	0.14967751	0.129867042	0.138643526	0.220191188	0.184904169	0.092865771	0.062136004	0.162655118	0.159769864	0.137098285	0.147107453	0.167750692	0.122028162	0.182869792	0.147229197	0.137664674	0.155363227	0.134019959	0.096302105	0.143074678	0.210247004	0.233355562	0.160735187	0.104793758	0.148842307	0.267208039	0.172460668	0.116465977	0.115971391	0.166715867	0.207188182	0.113201712	0.243209227	0.092299766	0.16577235	0.173716155	0.155895857	0.119098693	0.204776127	0.062509738	0.147008536	0.23367514	0.128138195	0.142732273
NMR_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	KEGG ID
Very low density lipoprotein
Isoleucine	C00407
Valine	C00183
BCAA
3-Hydroxyisobutyrate	C06001
Lactate	C00186
Alanine	C00041
Arginine	C00062
Acetate	C00033
N-acetyl-glycoproteins
Methionine	C00073
Acetone	C00207
3-Hydroxybutyrate	C01089
Citrate	C00158
Dimethylamine	C00543
Creatine	C00300
Dimethylsulfone	C11142
Choline	C00114
Betaine	C00719
Scyllo-inositol	C06153
Glycine	C00037
Creatinine	C00791
Glucose	C00031
Tyrosine	C00082
Anserine	C01262
Histidine	C00135
Phenylalanine	C00079
1-Methylhistidine	C01152
Formate	C00058
METABOLITES_END
#END