#METABOLOMICS WORKBENCH burlab_20190119_200209 DATATRACK_ID:1609 STUDY_ID:ST001140 ANALYSIS_ID:AN001870 PROJECT_ID:PR000761 VERSION 1 CREATED_ON February 21, 2019, 4:41 pm #PROJECT PR:PROJECT_TITLE Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess PR:PROJECT_TITLE Glucocorticoid Exposure PR:PROJECT_SUMMARY Glucocorticoids (GCs) are widely used in veterinary and human medicine. Chromic PR:PROJECT_SUMMARY endogenous or iatrogenic GC overexposure impairs metabolic function and can PR:PROJECT_SUMMARY result in diverse side-effects, including Cushing’s syndrome. This study PR:PROJECT_SUMMARY examines the effects of experimentally induced short-term and long-term GC PR:PROJECT_SUMMARY excess (induced by prednisolone and tetracosactide, respectively) on the plasma PR:PROJECT_SUMMARY lipidome of Beale dogs. Both, long- and short-term GC resulted in significant PR:PROJECT_SUMMARY changes of the plasma lipidome. PR:INSTITUTE National University of Singapore and University of Zurich PR:DEPARTMENT Multiple PR:LABORATORY Singapore Lipidomics Incubator (SLING) PR:LAST_NAME Burla PR:FIRST_NAME Bo PR:ADDRESS 28 Medical Drive, Singapore 117456, Singapore PR:EMAIL bo.burla@nus.edu.sg PR:PHONE +6565166683 #STUDY ST:STUDY_TITLE Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess ST:STUDY_TITLE Glucocorticoid Exposure ST:STUDY_SUMMARY Glucocorticoids (GCs) are widely used in veterinary and human medicine. Chromic ST:STUDY_SUMMARY endogenous or iatrogenic GC overexposure impairs metabolic function and can ST:STUDY_SUMMARY result in diverse side-effects, including Cushing’s syndrome. This study ST:STUDY_SUMMARY examines the effects of experimentally induced short-term and long-term GC ST:STUDY_SUMMARY excess (induced by prednisolone and tetracosactide, respectively) on the plasma ST:STUDY_SUMMARY lipidome of Beale dogs. Both, long- and short-term GC resulted in significant ST:STUDY_SUMMARY changes of the plasma lipidome. ST:INSTITUTE Life Sciences Institute, National University of Singapore ST:LABORATORY Singapore Lipidomics Incubator (SLING) ST:LAST_NAME Burla ST:FIRST_NAME Bo ST:ADDRESS 28 Medical Drive, Singapore 117456, Singapore ST:EMAIL bo.burla@nus.edu.sg ST:PHONE +6565166683 ST:NUM_GROUPS 2 ST:TOTAL_SUBJECTS 14 ST:NUM_MALES 9 ST:NUM_FEMALES 5 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Canis lupus familiaris SU:TAXONOMY_ID 9615 SU:GENOTYPE_STRAIN Beagle SU:AGE_OR_AGE_RANGE 8 to 83 months SU:WEIGHT_OR_WEIGHT_RANGE 12.2 to 18.9 kg SU:GENDER Male and female SU:ANIMAL_ANIMAL_SUPPLIER In-house breeding SU:ANIMAL_FEED Standard pellet/kibble maintenance diet #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS P1 Prednisolone-d0-P1 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=F; Age_months=83; Weight_kg=14.7 SUBJECT_SAMPLE_FACTORS P1 Prednisolone-d4-P1 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=F; Age_months=89; Weight_kg=12.6 SUBJECT_SAMPLE_FACTORS P2 Prednisolone-d0-P2 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=F; Age_months=72; Weight_kg=14 SUBJECT_SAMPLE_FACTORS P2 Prednisolone-d4-P2 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=F; Age_months=78; Weight_kg=11.8 SUBJECT_SAMPLE_FACTORS P3 Prednisolone-d0-P3 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=F; Age_months=71; Weight_kg=15.4 SUBJECT_SAMPLE_FACTORS P3 Prednisolone-d4-P3 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=F; Age_months=77; Weight_kg=12.2 SUBJECT_SAMPLE_FACTORS P4 Prednisolone-d0-P4 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=M; Age_months=23; Weight_kg=16.9 SUBJECT_SAMPLE_FACTORS P4 Prednisolone-d4-P4 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=M; Age_months=29; Weight_kg=14.1 SUBJECT_SAMPLE_FACTORS P5 Prednisolone-d0-P5 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=M; Age_months=23; Weight_kg=19.8 SUBJECT_SAMPLE_FACTORS P5 Prednisolone-d4-P5 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=M; Age_months=29; Weight_kg=16.5 SUBJECT_SAMPLE_FACTORS P6 Prednisolone-d0-P6 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=M; Age_months=88; Weight_kg=16.3 SUBJECT_SAMPLE_FACTORS P6 Prednisolone-d4-P6 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=M; Age_months=94; Weight_kg=11.9 SUBJECT_SAMPLE_FACTORS P7 Prednisolone-d0-P7 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=M; Age_months=58; Weight_kg=12 SUBJECT_SAMPLE_FACTORS P7 Prednisolone-d4-P7 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=M; Age_months=58; Weight_kg=13 SUBJECT_SAMPLE_FACTORS P8 Prednisolone-d0-P8 TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before Sex=M; Age_months=43; Weight_kg=13 SUBJECT_SAMPLE_FACTORS P8 Prednisolone-d4-P8 TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after Sex=M; Age_months=43; Weight_kg=14 SUBJECT_SAMPLE_FACTORS T1 Tetracosactide-w00-T1 TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before Sex=M; Age_months=56; Weight_kg=14 SUBJECT_SAMPLE_FACTORS T1 Tetracosactide-w25-T1 TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after Sex=M; Age_months=56; Weight_kg=15 SUBJECT_SAMPLE_FACTORS T2 Tetracosactide-w00-T2 TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before Sex=F; Age_months=43; Weight_kg=15 SUBJECT_SAMPLE_FACTORS T2 Tetracosactide-w25-T2 TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after Sex=F; Age_months=43; Weight_kg=16 SUBJECT_SAMPLE_FACTORS T3 Tetracosactide-w00-T3 TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before Sex=F; Age_months=8; Weight_kg=16 SUBJECT_SAMPLE_FACTORS T3 Tetracosactide-w25-T3 TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after Sex=F; Age_months=8; Weight_kg=17 SUBJECT_SAMPLE_FACTORS T4 Tetracosactide-w00-T4 TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before Sex=M; Age_months=7; Weight_kg=17 SUBJECT_SAMPLE_FACTORS T4 Tetracosactide-w25-T4 TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after Sex=M; Age_months=7; Weight_kg=18 SUBJECT_SAMPLE_FACTORS T5 Tetracosactide-w00-T5 TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before Sex=M; Age_months=7; Weight_kg=18 SUBJECT_SAMPLE_FACTORS T5 Tetracosactide-w25-T5 TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after Sex=M; Age_months=7; Weight_kg=19 SUBJECT_SAMPLE_FACTORS T6 Tetracosactide-w00-T6 TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before Sex=M; Age_months=8; Weight_kg=19 SUBJECT_SAMPLE_FACTORS T6 Tetracosactide-w25-T6 TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after Sex=M; Age_months=8; Weight_kg=20 #COLLECTION CO:COLLECTION_SUMMARY Blood was collected from the jugular vein after overnight fasting right before CO:COLLECTION_SUMMARY start and at the end of the treatments (12 h after the last prednisolone CO:COLLECTION_SUMMARY administration and 25 weeks after start of tetracosactide infusion, CO:COLLECTION_SUMMARY respectively). Plasma was prepared lithium heparin anticoagulated blood CO:COLLECTION_SUMMARY (Vacuette Greiner Bio-One, Germany) that centrifuged immediately after CO:COLLECTION_SUMMARY collection (1,862 g, 10 min, 4°C). Plasma samples were stored at −80°C until CO:COLLECTION_SUMMARY lipidomic analysis. CO:COLLECTION_PROTOCOL_COMMENTS Blood collected after overnight fasting CO:SAMPLE_TYPE Blood (plasma) CO:COLLECTION_METHOD Venepuncture CO:COLLECTION_LOCATION Jugular vein CO:COLLECTION_FREQUENCY Before and after treatment CO:STORAGE_CONDITIONS -80℃ CO:COLLECTION_VIALS VACUETTE® lithium heparin tubes (Greiner Bio-One, Germany) CO:COLLECTION_TUBE_TEMP Room temperature CO:ADDITIVES Lithium heparin #TREATMENT TR:TREATMENT_SUMMARY In the short-term prednisolone group, dogs were treated with 50 mg prednisolone TR:TREATMENT_SUMMARY (Streuli Pharma AG, Switzerland) orally twice daily for 3 consecutive days. For TR:TREATMENT_SUMMARY the long-term tetracosactide treatment, ALZET osmotic pumps (Durect Corporation, TR:TREATMENT_SUMMARY USA) subcutaneously delivering tetracosactide (synthetic ACTH; Bachem AG, TR:TREATMENT_SUMMARY Switzerland) were implanted into the dorsolateral neck. New pumps were implanted TR:TREATMENT_SUMMARY every 4 weeks. Total infusion time was 25 weeks, with a starting dose of TR:TREATMENT_SUMMARY 1.3–1.95 µg/kg/d tetracosactide, which was gradually increased to a final TR:TREATMENT_SUMMARY dose of 6–10 µg/kg/d. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Plasma lipids were extracted using a single-phase butanol/methanol extraction SP:SAMPLEPREP_SUMMARY method (Alshehry et al, Metabolites 2015 with modifications). After thawing on SP:SAMPLEPREP_SUMMARY ice, a 10 µL aliquot of each plasma sample was transferred into a 2 mL SP:SAMPLEPREP_SUMMARY polypropylene tube (Eppendorf, Germany). Subsequently, 1 µL BHT SP:SAMPLEPREP_SUMMARY (2,6-di-tert-butyl-4-methylphenol, 10 mmol/L in ethanol) and 90 µL of SP:SAMPLEPREP_SUMMARY 1-butanol:methanol (1:1, v/v) containing internal standards was added to each SP:SAMPLEPREP_SUMMARY sample. Following internal standards were added at 50 ng/mL final concentration SP:SAMPLEPREP_SUMMARY in the extraction solvent: ceramide d18:1/17:0 (Avanti 860517P), SP:SAMPLEPREP_SUMMARY Glucosylceramide (Matreya 1533), Lactosylceramide d18:1/16:0 D3 (Matreya 1534), SP:SAMPLEPREP_SUMMARY LPC 20:0 (Avanti 855777P), LPE 14:0 (Avanti 856735P), PI 12:0/13:0 (Avanti SP:SAMPLEPREP_SUMMARY LM-1500), PE 14:0/14:0 (Avanti 850745P), PS 14:0/14:0 (Avanti 840033P), SM SP:SAMPLEPREP_SUMMARY d18:1/12:0 (Avanti 860583P), and at 100 ng/mL: DG 12:0_12:0 (Avanti 800812P), PC SP:SAMPLEPREP_SUMMARY 14:0/14:0 (Avanti 850345P), TAG 16:0_16:0_16:0 d5 (CDN Isotopes D5815). Samples SP:SAMPLEPREP_SUMMARY were then vortexed (30 sec) and sonicated in an ultrasound water bath for 30 min SP:SAMPLEPREP_SUMMARY (20°C). After centrifugation (14,000 g, 10 min, 4°C), 90 µL of supernatant SP:SAMPLEPREP_SUMMARY were transferred into 1.5 mL polypropylene tubes (Sarstedt, Germany) and dried SP:SAMPLEPREP_SUMMARY under a nitrogen stream at 37°C. Dried extracts were stored at −80°C until SP:SAMPLEPREP_SUMMARY LC-MS analysis. Dried samples were reconstituted with 90 µL 1-butanol:methanol SP:SAMPLEPREP_SUMMARY (1:1, v/v) and sonication in an ultrasound water for 10 min. After SP:SAMPLEPREP_SUMMARY centrifugation for 10 min at 20,800 g (4°C), supernatants (80 µL) were SP:SAMPLEPREP_SUMMARY transferred into autosampler vials with glass inserts (Agilent Technologies, SP:SAMPLEPREP_SUMMARY USA). For the analysis of sphingosine-1-phosphate (S1P), lipid extracts were SP:SAMPLEPREP_SUMMARY derivatized according to the method described by Narayanaswamy et al. (Anal. SP:SAMPLEPREP_SUMMARY Chem., 2014). To 50 µL lipid extract (see above), 50 µL 13C2D2–S1P d18:1 SP:SAMPLEPREP_SUMMARY internal standard solution (Toronto Research Chemicals, Canada; 20 ng/mL in SP:SAMPLEPREP_SUMMARY 1-butanol:methanol 1:1 [v/v]) was added. Derivatization was performed by adding SP:SAMPLEPREP_SUMMARY 20 µL TMS-diazomethane (2 mol/L in hexanes; Acros Organics, Thermo Fisher SP:SAMPLEPREP_SUMMARY Scientific, USA) and subsequent incubation for 20 min at 25°C and 700 rpm SP:SAMPLEPREP_SUMMARY (Thermomixer, Eppendorf, Germany). To stop the reaction and inactivate TMS, 1 SP:SAMPLEPREP_SUMMARY µL acetic acid 100% (glacial) was added. After centrifugation for 10 min at SP:SAMPLEPREP_SUMMARY 20,800 g (7°C), supernatants were transferred into autosampler vials for LC-MS SP:SAMPLEPREP_SUMMARY analysis. Process Quality Control (PQC) samples were generated by pooling equal SP:SAMPLEPREP_SUMMARY volumes of plasma samples within an experimental group. For Blank samples, SP:SAMPLEPREP_SUMMARY plasma was omitted. PQC and Blank were processed together with the study plasma SP:SAMPLEPREP_SUMMARY samples with the same procedures. SP:EXTRACTION_METHOD Liquid–liquid extraction using butanol:methanol SP:EXTRACT_STORAGE -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1290 Infinity CH:COLUMN_NAME Agilent Zorbax RRHD Eclipse Plus C18 (50 x 2.1 mm, 1.8 µm, 95 Ã…) CH:FLOW_GRADIENT 20% B: 2 min, 20% - 60% B: 2 - 7 min, 60% - 100% B: 7 - 9 min, 20% B: 9 - 10.8 CH:FLOW_GRADIENT min CH:FLOW_RATE 0.4 mL/min CH:COLUMN_TEMPERATURE 40 CH:SOLVENT_A Water:acetonitrile 60:40 (v:v) + 10 mmol/L ammonium formate CH:SOLVENT_B 2-Propanol:acetonitrile 90:10 (v:v) + 10 mmol/L ammonium formate CH:SAMPLE_INJECTION 2 µL #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME Singapore Lipidomics Incubator AN:SOFTWARE_VERSION . MassHunter Data Acquisition B.06 AN:DATA_FORMAT .d #MS MS:INSTRUMENT_NAME Agilent 6460 QQQ MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Phospholipids, cholesteryl esters and diacylglycerols were measured with an MS:MS_COMMENTS Agilent 6460 triple quadrupole mass spectrometer in dynamic MRM mode. The ESI MS:MS_COMMENTS source settings were: polarity: positive, dry gas temperature 300°C, dry gas MS:MS_COMMENTS flow 5L/min, nebulizer pressure: 45 psi, sheath gas temperature: 250°C, sheath MS:MS_COMMENTS gas flow: 11 L/min, capillary voltage: 3500 V, noozle: 500. MRM transitions with MS:MS_COMMENTS collision energies are detailed in the attached protocol. Data were processed MS:MS_COMMENTS with Agilent MassHunter QQQ Quantitative Analysis (version B.08). For MS:MS_COMMENTS plasmalogen PE (PE-P), transitions with the fatty acid as product were used as MS:MS_COMMENTS quantifiers, and those with the head group as qualifiers. Plasmalogen PCs MS:MS_COMMENTS (PC-P), ether PCs (PC-O) and odd-chain fatty acid PCs were distinguished based MS:MS_COMMENTS on retention time (Alshehry et al., Circulation, 2016; Huynh et al, Cell Chem. MS:MS_COMMENTS Biol. 2019). Normalised peak areas were calculated by dividing the peak areas of MS:MS_COMMENTS the analyte with the corresponding class-specific internal standard. Relative MS:MS_COMMENTS abundance was obtained by multiplying the normalised peak areas with the molar MS:MS_COMMENTS concentration of the corresponding internal standard. Lipid species with a MS:MS_COMMENTS median peak area in the PQC samples below 250 or less than 5 times of the MS:MS_COMMENTS highest signal in Blank samples were excluded. Additionally, the coefficient of MS:MS_COMMENTS variation (CV) of the normalised peak area was calculated for each lipid species MS:MS_COMMENTS in the PQC samples of each experimental group. Species with a CV higher than 25% MS:MS_COMMENTS in any of the two groups were excluded from subsequent evaluation. MS:CAPILLARY_VOLTAGE 3500 V MS:COLLISION_GAS Nitrogen MS:DRY_GAS_FLOW 5 L/min MS:DRY_GAS_TEMP 300°C MS:FRAGMENT_VOLTAGE 135 V MS:NEBULIZER 45 psi #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS µmol/L MS_METABOLITE_DATA_START Samples Tetracosactide-w00-T1 Tetracosactide-w25-T1 Tetracosactide-w00-T2 Tetracosactide-w25-T2 Tetracosactide-w00-T3 Tetracosactide-w25-T3 Tetracosactide-w00-T4 Tetracosactide-w25-T4 Tetracosactide-w00-T5 Tetracosactide-w25-T5 Tetracosactide-w00-T6 Tetracosactide-w25-T6 Prednisolone-d0-P1 Prednisolone-d4-P1 Prednisolone-d0-P2 Prednisolone-d4-P2 Prednisolone-d0-P3 Prednisolone-d4-P3 Prednisolone-d0-P4 Prednisolone-d4-P4 Prednisolone-d0-P5 Prednisolone-d4-P5 Prednisolone-d0-P6 Prednisolone-d4-P6 Prednisolone-d0-P7 Prednisolone-d4-P7 Prednisolone-d0-P8 Prednisolone-d4-P8 Factors TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after TreatmentGroup:Tetracosactide | TreatmentDuration:00w | SamplingTimePoint:before TreatmentGroup:Tetracosactide | TreatmentDuration:25w | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after TreatmentGroup:Prednisolone | TreatmentDuration:0d | SamplingTimePoint:before TreatmentGroup:Prednisolone | TreatmentDuration:4d | SamplingTimePoint:after CE(16:0) 2.06515109 0.329376327 2.297941196 1.514528685 2.523259493 2.144915635 0.769873123 1.55203358 1.909081966 2.602192444 2.602305491 1.190505233 2.368837831 3.569008028 1.143139192 2.220072149 3.879174089 1.277055819 2.514061287 2.528734111 2.469602255 3.502378409 2.760719586 4.145120715 3.093803802 2.806502092 3.144947818 3.471401625 CE(16:1) 0.33679551 0.120584638 0.485195043 0.53064835 0.527161972 0.464392708 0.216673113 0.340584483 0.581606413 0.488241087 0.502008623 0.281055131 0.385594685 0.378247544 0.204439919 0.352224245 0.66136969 0.305576972 0.55358851 0.971464373 0.471216861 0.671953246 0.387882135 0.479074609 0.529264467 0.446527002 0.539459059 0.561148455 CE(17:0) 0.037594368 0.005285422 0.045414872 0.027424756 0.054777763 0.043437107 0.018963562 0.032796729 0.048130339 0.049304776 0.072951645 0.032462597 0.045397049 0.08172682 0.032910332 0.037285083 0.082177874 0.034595788 0.040481515 0.04348191 0.049564176 0.072671848 0.058707431 0.09337132 0.067442523 0.068485155 0.069911392 0.076143198 CE(17:1) 0.045856033 0.013126049 0.069240269 0.068458529 0.081731348 0.09097137 0.020184829 0.034627615 0.070608794 0.047702552 0.066620259 0.041349192 0.048371784 0.064089352 0.026871739 0.026428985 0.058659864 0.04616603 0.051397879 0.05842048 0.045686128 0.06535408 0.067564307 0.064723301 0.059052855 0.069779711 0.047783322 0.060724596 CE(18:0) 0.394058705 0.033987717 0.533578925 0.353145409 0.567905763 0.690497715 0.134271518 0.161993555 0.459920524 0.363049197 0.673202287 0.697763463 0.585634861 1.37658229 0.289349245 0.396135292 0.691699813 0.289830716 0.381504167 0.282308492 0.434307368 0.817296942 0.609934154 0.893972513 0.545653586 0.586244297 0.634892601 0.627097013 CE(18:1) 21.04693392 5.062944679 23.58307421 22.16447389 27.55035945 35.47520845 10.4387115 15.44132911 28.42308084 21.06264328 24.13158828 22.31702416 23.53270049 23.50236863 15.51743938 17.80048271 28.80939994 19.16614322 20.39711174 21.0734067 19.38098755 28.51252139 26.66059542 18.58857714 23.69495818 25.83409094 23.48989486 23.18970371 CE(18:2) 87.14995961 30.64386435 94.82786508 91.20574495 105.8012477 100.8114337 58.13268051 76.58597541 108.6227328 103.2862585 116.4279419 42.01260241 83.61037006 69.79440969 39.10706852 69.79763836 112.5606555 76.35819137 87.48153972 106.0880101 82.08021448 104.9409139 103.1478717 70.21503962 102.603328 96.96313961 77.10880442 91.302406 CE(18:3) 1.646421081 0.293393451 0.96533177 0.614438558 1.906565651 1.118704921 0.720513583 1.209060985 2.769345664 2.042907327 2.400685996 0.335568419 0.534072781 0.516374959 0.173307617 0.469956762 0.986188549 0.542766921 0.993351187 1.936031091 1.226585789 2.097130807 1.01661527 1.264564053 1.348622834 2.047355669 1.225029931 2.305255097 CE(20:1) 0.016523331 0.00262521 0.026831062 0.020947552 0.024237332 0.050471163 0.003290636 0.008637003 0.016849397 0.017806525 0.025360721 0.086644296 0.018753767 0.045837766 0.016773869 0.019765586 0.024653362 0.017661859 0.016222929 0.015929394 0.019118097 0.031833979 0.030736508 0.025014768 0.028063113 0.033437427 0.021529115 0.02795611 CE(20:2) 0.152120758 0.046063682 0.125908059 0.123893745 0.17955127 0.254930132 0.073309942 0.127286336 0.156895838 0.183454549 0.170173607 0.242988674 0.119334312 0.152841682 0.127011738 0.120839607 0.14862301 0.13796172 0.100483611 0.123814834 0.124607808 0.230256788 0.193696015 0.137870599 0.165224426 0.173817787 0.147243174 0.15865013 CE(20:3) 2.570855972 1.049698902 1.288550769 2.042145152 2.07793334 3.524170681 1.147889171 3.460651988 2.386494128 3.861539829 2.61324472 2.53158519 1.196490305 1.119659894 0.950440981 1.070186706 2.617149019 1.570756053 1.120974091 1.128509905 1.953175518 2.689735162 2.487031632 1.515579857 2.44071044 2.31870718 2.042071489 2.255864915 CE(20:4) 52.53380859 11.47111688 71.99144215 29.76636809 88.03841742 44.48470981 38.20041636 33.22308697 81.10623265 55.4525786 86.10875965 24.44801626 73.00315348 49.37046709 29.39925877 38.60806728 79.73351446 42.85291769 47.49823529 53.62489439 65.08630159 80.03045442 81.72809603 47.94851989 66.55299064 67.90478397 69.99870608 63.88221156 CE(20:5) 1.099635256 0.316075264 1.226091575 0.770821681 1.254490877 1.686360468 0.51456048 0.582659372 1.416709353 1.517851522 1.369197566 0.887896795 0.711479102 1.506038359 0.275795959 0.292628008 0.913742265 0.421509259 1.014236313 3.127153422 0.709954944 5.111882801 0.670602001 3.764143866 1.026661204 3.733846036 0.656088963 5.238968603 CE(22:4) 0.278736466 0.039693173 0.532112747 0.160586415 0.652039951 0.236946155 0.129589994 0.088917347 0.375182415 0.183527377 0.331518447 0.247498289 0.510318011 0.580439746 0.310316582 0.404034039 0.395048502 0.35339042 0.209230303 0.2894348 0.219449897 0.59681966 0.452120737 0.278699243 0.354479722 0.507813165 0.286300626 0.430232812 CE(22:5) 0.924510686 0.224402936 1.255781685 0.320414859 1.239586311 0.445901119 0.563682551 0.470975364 1.14632565 0.526512371 0.961139688 0.385373139 0.84137588 0.653446091 0.352989305 0.460972404 0.917256451 0.466794111 0.459738106 0.575630369 0.539082702 0.988674358 0.874485173 0.545919986 0.764402791 0.711532032 0.650898017 0.651602142 CE(22:6) 1.086939578 0.246104671 1.041792967 0.277176079 1.402631122 0.842817654 0.383749218 0.446576826 1.18399123 0.846301543 1.129378704 0.294583976 0.368349842 0.331156977 0.138921185 0.310446983 0.492850985 0.307301015 0.355994747 0.73675352 0.545546116 2.289180076 1.00159709 0.917186732 0.840657717 0.964317718 0.85470919 1.178842338 CE(24:4) 0.006380592 0.020315023 0.005468281 0.017556932 0.005244246 0.013294284 0.002350051 0.012804489 0.006327342 0.021481191 0.009557024 0.015111749 0.009462765 0.020018252 0.008252273 0.021339092 DG(16:0_20:4) 4.95738225 3.090713625 7.172138672 6.739897782 6.387984844 9.050282719 2.226231844 3.947545125 2.918582297 4.697272688 5.251918078 16.10001689 15.95083641 11.28416484 50.2891238 25.5825405 7.000007344 32.68582664 10.63771608 6.326782594 5.944268531 7.168313532 6.644269266 3.182517 6.969406219 9.811485704 4.758474938 2.658472734 DG(18:0_18:2) 2.75410125 7.133887266 4.551917344 18.95739694 3.557380781 29.62571414 3.377599172 7.007657625 3.480877969 10.18252434 4.200004406 56.86454053 14.94099928 29.29292691 39.06233606 26.28636638 7.52787675 35.26014628 8.759572032 6.315307172 5.44317511 7.459024219 8.170500375 2.639347031 5.600005875 11.61695208 5.13716386 4.681972125 DG(18:0_20:4) 6.644269266 4.471589391 9.168862078 10.12514723 8.583615563 14.18362144 6.085798735 5.163939844 7.240991203 8.805473719 8.055746157 25.04702081 15.5453715 17.01040036 35.03063785 19.35521156 8.839899985 26.29019152 7.359570563 6.047547328 6.644269266 9.383069954 9.520775016 4.364485453 7.990718766 12.0989198 6.154651266 6.154651266 DG(18:1_18:2) 42.41698439 46.90769949 42.26397877 86.28752222 34.27708514 100.9722371 27.95795283 33.28254858 26.11806019 67.43722922 34.7437523 340.3533625 DG(18:1_20:4) 12.82952166 5.083611891 22.90111692 12.39728077 19.98635977 21.89510494 10.526787 7.428423094 14.41695502 10.32405455 15.38854073 53.99951021 30.66615239 15.08252948 84.04981496 24.31641895 17.14810542 33.63828666 17.44646639 9.157386657 9.865037672 9.394545375 16.50930694 3.033336516 13.57159894 8.216402063 10.51913672 4.735524094 DG(18:2_18:2) 15.31395049 37.71588656 35.88938192 20.27324531 11.4027442 25.13691162 8.771047453 9.029244446 6.703558946 7.332794578 8.893451953 4.295632922 7.661756672 18.09291516 6.378421992 6.814488024 DG(18:2_20:4) 11.59017609 2.845904625 17.1175043 8.247003188 16.1765197 12.84482222 6.908203969 5.733885797 9.260665453 10.45793447 15.02897752 18.91149525 17.69892567 9.54372586 48.47600714 20.9311695 11.7317063 31.31260116 10.79837198 5.894541703 5.645907563 6.812575453 10.66449206 3.5497305 9.822961125 9.080883844 6.896728547 2.953008563 LPC(14:0) 0.545777439 0.50198781 0.608605037 0.686559397 0.687072669 0.987275186 0.474748552 0.582457237 0.666944031 0.740994343 0.575393348 0.905861261 0.818761823 0.585258485 1.138381445 0.677932813 0.978287111 0.596919459 0.766823959 0.958003283 0.964272191 0.975189667 0.991405911 0.777009276 0.77536943 0.816644078 0.975929268 1.514657529 LPC(15:0) 0.448298184 0.440554264 0.399173304 0.438763429 0.45750463 0.671436304 0.337630063 0.532954647 0.406002479 0.688212943 0.504939878 0.45459228 0.469039436 0.338190628 0.543955666 0.400356216 0.645697611 0.425226678 0.424680188 0.508002675 0.680258181 0.825764599 0.604527669 0.616688044 0.46909384 0.560807878 0.499189802 0.905674546 LPC(16:0) 73.68168311 94.13358447 66.62422354 95.81274397 74.55647408 145.3338187 63.86643418 68.88850169 72.01446455 92.73422197 78.69246383 148.1783678 80.66847435 82.17944268 84.12754947 69.64666888 97.29568424 76.15188981 76.12125379 117.3098504 90.96466832 123.2709687 107.2287796 82.50387929 86.20678153 107.4490271 84.1936425 149.8594094 LPC(16:1) 3.356318472 3.242372787 3.691138406 4.71854195 4.071628062 6.285441458 2.854949011 2.658358814 3.9263718 4.117462844 3.783477388 5.035846989 4.541590917 2.703276287 5.155124314 2.403111736 4.386325295 2.543616535 4.396184883 6.544839862 3.671843149 4.792597001 4.059545029 3.22320098 3.887810556 3.78581599 3.690967135 5.465099818 LPC(17:0) 2.23098497 2.435461395 1.871460489 1.417397672 1.970089983 2.644376517 1.761337577 1.527050324 1.870301275 2.434108626 2.566719352 1.910372019 2.409792964 1.35012269 2.341578514 1.176289994 3.030460732 1.493299966 2.253402388 1.708749825 3.034896738 3.11761215 3.058527992 2.235919875 2.590163102 2.363271349 2.715830231 3.153378048 LPC(17:1) 0.231529854 0.325681949 0.234236224 0.369148508 0.229917635 0.526769711 0.192654706 0.193548155 0.212667965 0.312322052 0.268927757 0.369935618 0.249605782 0.20619949 0.255089255 0.154518567 0.290413296 0.179703331 0.270550682 0.417048278 0.29147651 0.515814915 0.306339438 0.313704882 0.302776631 0.341045826 0.306513103 0.483153971 LPC(18:0) 146.0031782 147.1217009 133.0927158 108.6854663 125.8680772 173.5776177 118.1449064 66.65000851 135.1864569 118.4331129 174.215043 107.7261265 144.0686173 107.9194746 113.9647762 64.69608887 132.7534204 84.738665 111.5400561 104.4383122 124.9052935 154.9196588 147.0564347 97.61645744 123.3983886 121.9791342 126.9294399 141.7779492 LPC(18:1) 29.18938496 34.86886715 32.16170761 38.03283331 32.9248346 59.19167442 24.71232498 25.39510764 30.47324197 39.01932376 33.81178271 39.91649047 33.10622974 27.11361966 34.90536512 19.40600078 38.55768723 21.74156634 36.96392096 54.78019334 34.72828489 55.39827052 45.16827812 31.17800177 40.33087356 38.8477111 34.88253816 54.95887455 LPC(18:2) 49.53475505 70.1750626 43.36975751 92.68622896 44.39950753 124.0750132 36.60299495 53.44996854 43.42665439 89.26695919 51.74240087 56.84362493 40.25908115 46.04994833 47.79063284 42.42105415 56.17770055 53.40393141 61.36173843 136.6318448 57.45042991 72.7186987 75.89018202 40.33889068 66.43509433 65.10782505 57.01434252 74.84029988 LPC(18:3) 0.524499566 0.785872506 0.423977795 0.661696925 0.534648814 1.124386418 0.370349074 0.596541072 0.498226645 1.140258019 0.585898338 0.800215344 0.324624663 0.406434935 0.489051486 0.471351233 0.567370374 0.535505245 0.610980438 1.570379857 0.491354479 0.738643607 0.604284349 0.49673093 0.606719581 0.758075418 0.538411858 1.012371661 LPC(19:0) 0.711345887 0.388377828 0.5316344 0.178654618 0.645121149 0.351014663 0.525226237 0.171794904 0.62767671 0.343271729 0.798659413 0.214615132 0.941781816 0.360384694 1.032876738 0.234283557 0.964429216 0.286110132 0.855161658 0.377684407 0.764540546 0.781471114 1.141655794 0.435554064 1.018663749 0.525044714 0.812834188 0.571455031 LPC(20:1) 0.624372582 0.499042366 0.598632097 0.422306841 0.651763473 0.722342101 0.53792638 0.381100222 0.571717777 0.483765284 0.612791114 0.393023799 0.561887301 0.460697959 0.517481679 0.360543324 0.614165877 0.411742252 0.501942712 0.604324873 0.546372134 0.990791864 0.72825571 0.436689304 0.616749932 0.701165339 0.60206516 0.705525475 LPC(20:2) 0.681157905 0.752911585 0.515779983 0.428936833 0.540708478 0.85350813 0.42663869 0.564887304 0.493063052 0.854262455 0.650469013 0.7258784 0.461359259 0.348945462 0.554519178 0.4094046 0.595688682 0.428831425 0.4927134 0.672317012 0.629630233 1.184405704 0.86731289 0.513002715 0.656987966 0.663225287 0.691206196 0.883893618 LPC(20:3) 4.007022421 7.195439129 1.810472127 4.602635475 2.175652431 8.276712711 2.38655053 5.058606939 2.575912208 8.331242111 3.746499821 5.769246538 1.476788495 1.163770756 1.855526544 1.234199655 3.227684699 2.379133249 2.090307265 2.932459233 3.37012399 6.10946431 4.660057923 3.280972125 3.543046411 3.281607207 3.465935541 4.662443176 LPC(20:4) 32.92511451 20.73382174 36.23130629 19.99215028 33.01165094 28.26683674 31.02160516 17.96469914 35.47111927 33.70406988 45.70329192 16.69083043 35.33348133 20.46322171 31.5606442 17.64963973 32.00290249 26.73093719 28.59715432 49.72432169 33.97720612 55.01889629 49.88758438 24.84045679 37.72333229 35.80068952 32.46582562 38.14473373 LPC(20:5) 0.568784139 0.522886436 0.455175196 0.403482398 0.314053739 0.525531127 0.369918561 0.354884766 0.406963147 0.566212142 0.526790258 0.503217387 0.275389236 1.682935901 0.247264431 0.158416333 0.306078743 0.236044197 0.456719085 5.317402815 0.280648568 2.390172806 0.303784582 1.615447695 0.290297008 2.561575503 0.249594901 3.195173883 LPC(22:0) 0.084579545 0.057646546 0.072751316 0.030900501 0.09730422 0.056107848 0.079537334 0.026773232 0.097868092 0.051625602 0.111633033 0.064716869 0.100253751 0.102562003 0.106939258 0.054151101 0.122110155 0.056874903 0.108510337 0.066202873 0.098329425 0.078429836 0.120321567 0.070006518 0.107884585 0.091325645 0.104063906 0.104783925 LPC(22:1) 0.138971107 0.127495647 0.14217832 0.070562063 0.150675875 0.109119237 0.146912667 0.095379639 0.163313627 0.123413443 0.150711597 0.128734097 0.11931705 0.091904941 0.122328078 0.122362001 0.211885219 0.15273448 0.117739649 0.156113531 0.120277958 0.138849082 0.137718922 0.103937605 0.127362127 0.138906203 0.171150789 0.176454953 LPC(22:5) 4.270469085 3.210393681 4.628083303 1.479435459 3.683110376 2.032887671 3.407189958 1.923768265 3.344807172 2.838123912 4.5833974 2.578355058 3.056162223 1.618113586 2.697738409 1.316331146 2.535392423 1.873667565 2.202904868 2.896673896 2.208461331 5.408307861 3.776564277 2.288519367 2.919298561 2.758117413 2.312516566 3.067431682 LPC(22:6) 0.987027328 0.843519053 0.85358135 0.311017682 0.635448993 0.752935122 0.550196009 0.354048103 0.65709718 0.800710524 0.769805706 0.717482698 0.418021112 0.788329296 0.461012534 0.302355251 0.442448472 0.446454634 0.414132403 2.024555421 0.446433149 2.700017778 0.8049014 1.167910534 0.555984668 1.217398839 0.566144624 1.573083397 LPC(24:0) 0.086973305 0.065080286 0.091802188 0.044752449 0.112802976 0.0812511 0.095681583 0.029283222 0.114679789 0.059459338 0.142447672 0.075911139 0.122608554 0.171001853 0.115285737 0.07976499 0.178746773 0.094791504 0.120376595 0.08916513 0.1261309 0.121885619 0.153778018 0.109235395 0.138208901 0.106978508 0.120571505 0.15231933 LPC(O-16:0) 1.261644874 0.634252271 1.045368652 0.511693346 1.081999615 0.945658769 1.390019847 0.405781795 1.409060363 0.670490721 1.371811696 0.885571648 0.879654662 1.021806954 0.92385086 1.08608456 1.120882851 0.964737197 0.838153355 1.219981769 1.059967792 2.14189892 1.703480865 0.978829868 1.444020594 1.863623665 1.350981924 1.907155744 LPC(O-18:0) 0.60548847 0.396793382 0.458883084 0.279288432 0.548632654 0.591176071 0.583560791 0.257552913 0.60906376 0.448449262 0.708736694 0.363988663 0.38003166 0.499610902 0.356159895 0.459936348 0.551905765 0.484237727 0.359020227 0.415109905 0.5169611 0.769533863 0.677280244 0.434797236 0.557617516 0.640419791 0.610517051 0.76527586 LPC(O-18:1) 1.201135923 0.811259428 1.068638844 0.637781595 1.118823727 1.207619253 1.469126668 0.487774818 1.674685174 0.821001184 1.429519111 0.895016812 1.105397034 1.004012593 0.949281537 1.116292244 1.254440833 0.961532977 0.812443129 1.083848384 1.199706782 2.284412947 1.802146983 1.096642638 1.520531176 1.909856625 1.504832749 2.153957209 LPC(O-20:0) 0.060109991 0.027070033 0.038485319 0.013970341 0.041718456 0.030593021 0.048755632 0.009761074 0.04803342 0.021574879 0.069192871 0.022563449 0.030583566 0.033242213 0.030516813 0.027980389 0.040368653 0.030440089 0.03282998 0.022067624 0.032337504 0.044398198 0.049393889 0.028507159 0.04467005 0.034933873 0.042127393 0.036939277 LPC(O-20:1) 0.041225879 0.019636293 0.035033147 0.016456588 0.038921688 0.035547356 0.052307367 0.01282884 0.04431083 0.023115941 0.05504615 0.02291327 0.025097724 0.032753357 0.02516985 0.031042919 0.035347676 0.042188895 0.022150348 0.032057697 0.028972063 0.065654883 0.042094299 0.032165157 0.037788763 0.051208705 0.035260232 0.043561857 LPE(16:0) 2.743442921 1.76754086 2.465206695 2.04161651 2.374810238 2.714643026 1.830236948 1.578306981 2.2061705 1.938620602 2.147862596 3.596887207 2.541878843 5.748725042 2.338158713 2.042557557 2.1623271 2.14414853 2.517106766 3.033403223 1.82239529 3.362311054 2.715312077 2.761476579 2.633819516 2.973591441 1.324932131 4.265996092 LPE(18:0) 6.776932285 6.952653799 7.257104295 8.8284794 6.437258946 11.35756232 6.807013061 6.10130691 6.60031211 8.23913756 6.645490717 9.474594086 8.623576328 24.75889807 7.498672495 6.379035724 8.453957978 7.922587426 6.757502197 7.456559464 7.484766667 9.29861471 8.796436033 9.808138091 7.86537883 9.032308898 7.023712913 9.860907402 LPE(18:1) 2.230356268 2.258796445 3.139067295 2.621899825 3.222956751 4.341044589 2.296973591 2.514796034 2.582291227 2.656948772 1.972880057 3.209166066 2.993819396 7.143278045 3.633596329 1.711130715 3.091925667 2.688464228 4.22029877 3.669100689 3.152843437 3.996508818 3.275581261 2.865276763 3.269724571 3.841967776 2.480807639 4.616544518 LPE(18:2) 2.948677583 3.572619522 2.790905985 6.543307358 3.087945674 8.98693303 2.272500508 4.496762089 2.238524971 3.943015832 2.044026803 3.773455051 3.34940714 5.655348858 4.041340628 2.718444879 3.438841074 5.242401763 5.119624341 4.228438099 3.431679874 2.435815437 3.814866581 2.034875295 4.311526469 3.190685525 2.976182858 3.10344284 LPE(20:4) 1.363344536 1.516200793 1.18299972 1.904310035 1.464350919 2.632897189 1.40545416 1.348221309 1.538859533 1.495507322 1.355633957 1.700148103 1.901820903 2.644981896 1.580009158 1.020347804 1.852460912 2.4173412 1.715752416 1.636014199 1.609284584 1.789217157 1.961991339 1.412074194 1.9415399 1.786544891 1.578517064 1.705210137 PC(29:0) 0.029067419 0.033882708 0.03002 0.024082794 0.04370381 0.027302288 0.031481548 0.018189448 0.037778916 0.026800823 0.044319707 0.040719172 0.039749363 0.035373195 0.030662633 0.030733989 0.046333183 0.036817887 0.036160455 0.025723303 0.037079583 0.034160827 0.041903873 0.029966278 0.039216819 0.033500576 0.041693943 0.038625655 PC(31:0) 0.156365284 0.105323418 0.189833431 0.091266555 0.178471734 0.125634036 0.217012354 0.146431029 0.162184887 0.148861095 0.177173307 0.135288454 0.180424168 0.324377115 0.170992823 0.204057218 0.291298936 0.188648572 0.161205884 0.152815477 0.203359399 0.161125796 0.225867828 0.339114088 0.173484021 0.168765862 0.194294439 0.187587712 PC(31:1) 0.072611702 0.07819625 0.089656801 0.094677423 0.108754581 0.088614599 0.061775754 0.035742067 0.087987096 0.09973839 0.103623697 0.138703824 0.115367998 0.042742611 0.12416018 0.051135968 0.130349246 0.087159931 0.111362071 0.083381612 0.070008973 0.067478593 0.082057376 0.05382355 0.088091512 0.054813384 0.075967495 0.087952517 PC(32:0) 7.342270973 6.218422036 8.549835284 7.114415722 8.669582244 10.08447911 10.80461665 6.097883176 9.510539889 7.505104483 8.581631993 13.95875096 9.746526477 18.9033865 10.10823556 9.503653261 12.54353332 9.562421413 11.13389492 9.580234711 8.724179443 8.607145775 12.02980733 13.65385144 12.10430698 10.68848357 10.59002854 10.15158208 PC(32:1) 9.87007533 11.26946576 12.84375826 17.76025108 12.845786 19.12527113 9.671213064 7.064590659 12.32159348 12.70548381 11.77919336 34.437908 15.45034446 7.981101779 15.47570599 8.670765895 13.77344414 11.73214818 17.61495517 14.59300155 9.877796695 9.070390869 11.83646139 6.679875536 12.45498209 9.795366419 11.5453955 10.36794907 PC(32:2) 2.23641011 2.454291171 2.844385836 3.96835525 4.035446142 4.674275046 1.89164075 2.1014186 3.313362055 3.889760804 3.015428478 5.244748706 4.245249176 1.722257016 5.497367276 2.409829264 4.467556851 2.9568863 3.871897726 2.651291362 2.50947131 2.25586231 3.259365175 1.525675791 3.204332797 2.26629346 3.11856051 2.798871976 PC(32:3) 0.06090136 0.067030358 0.06612464 0.068803062 0.086258436 0.08310338 0.049868401 0.05210063 0.075935621 0.112592589 0.072212984 0.122058039 0.075575524 0.046230801 0.109768201 0.059034715 0.082015681 0.056548597 0.086572828 0.091460635 0.047114882 0.054731513 0.05142589 0.039001175 0.062694882 0.062864889 0.054970785 0.080480669 PC(33:1) 1.105964147 1.423318765 1.376888009 1.750050832 1.442504319 1.930739516 1.037568056 1.190155103 1.176851015 1.67137363 1.373488839 3.079370791 1.567125089 0.819896627 1.338252839 0.894617388 1.801155172 1.351955891 1.488605378 1.32812274 1.443314248 1.725981684 1.340503853 1.319770167 1.186585181 1.133209879 1.208525386 1.397330573 PC(33:2) 2.037902753 2.883985516 1.981356654 3.208420784 2.669449608 3.638492215 1.616686064 2.828399503 1.951243236 4.342024699 2.303745429 3.732170739 2.648592293 1.10683711 2.377729519 1.818995461 3.441630976 2.889457078 2.301760757 2.121886722 2.623363459 2.425283825 2.411765695 2.005522065 2.097156797 1.844741911 2.048460345 2.180608208 PC(34:0) 5.169149769 5.008270309 6.636472648 5.574667287 6.988709336 8.449459993 7.243300422 4.125780807 7.101302854 6.002182767 6.211899444 12.35498592 7.240937043 15.28755811 9.71794117 6.036065651 10.07003339 6.171267939 10.00378596 7.498438233 6.362448157 6.548053876 9.644507237 9.315139567 10.27227019 9.14944626 7.749017256 8.37806295 PC(34:1) 72.47807545 94.21958594 79.50421289 106.1752171 80.2734518 125.7760588 67.38014786 77.06097076 78.03669572 91.30126526 72.92308389 168.2243283 95.32203259 61.85062172 76.61575504 58.37657349 104.6529815 77.76543156 92.72567742 94.8830534 66.50791238 87.88252114 75.39343466 72.6828526 70.17631906 72.18382742 69.97614543 81.37979174 PC(34:3) 22.28193921 26.75613861 25.25411423 36.3333223 34.36557685 42.54900294 17.72122816 18.18228394 29.26713739 36.7674888 27.01687158 45.69102252 34.59005058 14.8959228 34.65374042 15.86600082 32.44279731 22.82789476 34.53118726 32.10942795 18.13729073 18.56045745 22.53556694 11.50627893 25.40475947 20.09516753 19.77677141 18.62253656 PC(34:4) 0.401183444 0.374214911 0.509496947 0.376883671 0.901308374 0.556052981 0.346229183 0.364266588 0.734648802 0.824016076 0.604330868 0.671368951 0.771792939 0.374931307 1.162328498 0.464903061 1.121349525 0.691915762 0.667490151 0.62124636 0.90048957 0.640254157 0.854425926 0.409689173 0.766939203 0.669095864 0.955300402 0.924482899 PC(35:1) 5.095590628 6.74542416 6.195702806 4.854043935 6.302124222 7.622342062 4.52686346 4.507002985 5.648174626 6.826708641 5.861914452 9.541748739 7.419162493 3.129348687 6.536072358 2.675317026 8.837527478 4.641199292 7.651006361 3.99031316 6.964532132 7.28229246 7.056304182 5.618291215 6.830717912 4.687270542 6.965450644 5.625161836 PC(35:2) 10.29301197 14.34747179 8.561198166 11.30974872 9.781051968 15.83576235 7.06095848 8.979378356 8.679441515 14.94353463 10.7536494 12.33727905 11.30796077 5.074997258 11.23044096 5.973549498 17.281304 9.71038258 15.07155616 7.979444954 12.75615883 9.296297463 13.08580594 6.685952388 12.76959463 9.589879378 11.50200451 8.79958916 PC(35:3) 1.742984033 2.66672315 1.569507179 2.900374628 1.791229382 3.547629619 1.184561104 1.829651526 1.622906677 3.074666198 2.037580964 3.025122774 1.861106547 1.024004878 2.028866586 0.901393091 2.648992945 1.510146378 2.339778509 1.812368691 1.788528564 1.861343539 1.944521755 1.267779319 2.112147637 1.70205661 1.695010177 1.66593718 PC(35:4) 0.802632172 0.726098037 0.926258119 0.516212454 1.30982582 0.58973668 0.692458367 0.939562617 0.897967056 1.236333634 1.111017683 0.720709446 1.204595382 0.460220011 1.076446288 0.675998025 1.562623081 1.225372853 0.951997879 0.746433104 1.678072229 1.570251478 1.186121163 1.200805331 1.092770486 1.131315407 0.991171168 1.398343705 PC(36:1) 62.02585588 70.04234846 66.53165087 60.21818281 60.86714934 85.44292842 52.35021892 40.30324015 62.48402267 58.98165713 68.77504066 85.52597821 68.45827516 35.64323536 52.34034302 25.67216489 68.3120335 42.07315238 68.4983245 43.54909547 48.56833407 60.56596592 56.46412135 43.31737959 53.27156124 45.7288865 49.3014735 43.96277112 PC(36:2) 174.9997732 213.1171944 154.0934664 230.5301531 152.6487371 259.6430945 125.7398144 189.5288767 162.8364219 203.9689043 153.7238551 218.6937522 175.9814652 119.8557841 157.2975295 156.3778317 245.0378756 187.2650087 206.0298374 190.1742118 156.2347192 146.474342 168.4501395 122.7695564 162.3303484 156.9552832 158.2073498 147.7782431 PC(36:3) 81.35053572 100.2144101 73.81742056 91.56753812 81.2894348 116.3656163 62.56357274 90.13436804 79.98608779 109.5222201 83.50444922 111.9704608 88.49423887 42.76061706 84.86943806 52.5163392 121.5236664 71.11032065 100.3134598 66.6854349 81.79327294 66.03429487 89.36286271 44.39446149 90.88335235 66.89563042 80.89134014 63.83905847 PC(36:4) 120.9319856 104.8059021 123.3865985 85.74115567 121.7877531 100.6157492 112.4393352 104.007504 125.7070765 114.8612282 128.9698915 103.2317551 153.2779829 77.6120824 112.6022465 103.8336036 171.7903039 128.6191712 121.7638112 114.366074 128.4839854 126.0094774 131.2879504 100.6047034 116.5693608 120.6976822 111.8365978 113.5038628 PC(36:5) 9.742133208 9.914577469 10.92178183 8.222396522 13.40940844 10.52175082 7.193805186 6.183138752 11.2708107 11.80412406 12.265268 13.65408666 13.07262553 23.91205901 13.70126546 4.625783583 13.92817643 8.428959186 13.78740517 42.68894631 9.835206202 24.92243092 9.631029383 15.81274168 11.26986022 37.39763103 8.5616332 35.00218897 PC(37:4) 13.40064881 8.388735509 13.28892664 4.892321452 14.60125138 6.817994166 12.61741784 6.111973034 14.26996551 9.717774634 16.71461488 5.37191322 18.55044985 5.332140737 13.43798281 3.803228228 18.07572615 9.119917147 13.97775926 6.601018865 15.27784259 13.00289894 16.41847663 8.70195622 14.718599 11.06330482 12.63190038 9.669647877 PC(37:5) 2.034264588 1.741879228 2.10741133 1.087584499 2.009574313 1.347202957 1.538016117 1.15942807 1.923249059 1.878424556 2.32467418 1.322544112 2.074856373 1.512523445 1.836939973 0.798933982 2.475338123 1.21043115 2.125999722 2.241890696 1.865068986 3.262915395 1.897996903 2.336919514 1.904779764 3.145328373 1.614151214 3.16644891 PC(38:2) 3.815638838 4.259070426 3.145025689 1.980060466 3.487494389 4.8112941 2.600382677 2.190654362 3.106409153 3.052708458 3.796721607 5.068310014 3.094759489 1.623752493 2.963640773 1.574583504 3.435305442 2.05218537 3.212443231 1.551134254 2.596625338 3.168222797 3.307080279 1.681487574 3.21587672 2.460287372 2.938507896 2.460074322 PC(38:3) 53.34917434 80.12728455 23.6743438 42.76418632 30.64967347 69.63544732 32.2857187 47.63661275 36.94385091 68.69823009 49.80701488 62.7585894 23.91665692 10.42831278 22.88757561 9.667206 41.83540388 23.65298324 25.86473166 11.52392563 33.47017438 39.04292509 40.24406673 25.74315452 35.92923998 26.06505862 33.36230842 28.10209556 PC(38:4) 192.8051783 131.7482906 200.5879585 105.1904065 197.6388321 116.0028548 180.505869 135.1349437 208.1207996 150.2596537 203.6500759 92.38798764 235.961184 105.6408198 162.0775791 128.4948037 246.4274927 158.3886744 172.5479098 140.0129316 179.3722086 164.9342728 184.5329651 139.3891369 162.0456525 143.6673949 160.7880485 136.5629042 PC(38:5) 76.03646573 49.5898637 84.89480056 27.35743406 76.70575831 33.09570343 64.78532874 48.2596312 74.7660994 47.43123054 80.39971302 34.02308972 95.0158073 49.50638368 63.84265486 30.78295403 77.27585539 39.60236947 64.20140877 73.05814515 55.27058769 84.3608535 56.60747671 61.01265942 55.35161352 77.13471371 48.57314388 74.3767388 PC(38:6) 27.03645191 26.39504975 26.26731672 17.77506596 29.48743071 29.11402907 17.40101875 12.96911642 24.68504599 24.22463063 27.04395585 27.84654179 25.01830059 23.33864478 24.48243511 13.39301902 27.9519387 21.81201224 25.10790168 41.03007906 17.68042945 45.83398284 25.24265517 24.86403654 25.07918833 37.38860072 19.1525269 32.99678926 PC(38:7) 1.032063928 1.026317033 1.025078534 0.742776767 1.290846875 1.207355777 0.551775198 0.503453679 0.938806064 1.236697776 1.252137259 0.954745208 0.828356024 1.24019897 0.944804961 0.398156772 1.048200405 0.67754874 0.985050202 2.989124081 0.726589729 1.871257935 0.890413546 0.926928988 1.08246225 1.853267034 0.698847715 1.782384033 PC(39:5) 1.822493089 1.128840228 1.872272991 0.363309106 1.808536787 0.559570009 1.430205384 0.687417858 1.503751975 0.944219225 1.972860121 0.640962208 1.961730205 0.413792692 1.41997513 0.467673238 1.614092381 0.655557619 1.295029444 0.606650767 1.144432401 1.375706748 1.24461855 0.869536492 1.254255331 0.877645634 0.922990092 0.801387368 PC(39:6) 0.307690193 0.275577027 0.252036044 0.043617765 0.238124823 0.093690721 0.235365283 0.113992516 0.190519074 0.207779209 0.271229575 0.146098266 0.212327127 0.12987367 0.162203316 0.080297694 0.208634483 0.103021123 0.168369747 0.189780817 0.132670066 0.548124463 0.212670033 0.386603564 0.156054324 0.294369342 0.153998058 0.302324904 PC(40:4) 16.3067086 9.524681305 18.97322647 2.628297624 18.60821169 5.605199686 10.90676206 3.577908257 13.56822215 4.16723672 12.43020062 8.557591556 22.89830584 8.29400717 17.65627545 8.753684026 16.69075866 13.71958617 11.0436833 5.54045659 7.894447242 14.54559919 13.74135475 6.276520437 11.98509566 9.752709229 8.996840764 8.78945784 PC(40:5) 14.47061029 10.79549288 16.48666144 3.812488925 12.37566533 4.438525406 12.83395525 8.498372924 11.72623554 7.666309979 13.18525367 8.056924801 12.46646931 4.021441024 7.891266805 4.772378348 10.92522392 6.048362858 7.504014493 3.979947622 6.645409596 8.398100399 7.634346583 7.227981903 6.78951749 5.601984674 5.96795717 5.236942339 PC(40:6) 21.8771176 16.63094931 20.63825516 4.47743589 17.78271463 8.988254157 14.29262294 8.04411434 16.67712471 11.84290514 18.60703122 7.046074676 16.0451622 7.138212574 12.45191413 5.36871507 12.76849525 7.809146717 10.48384063 9.104715628 9.97352325 19.4194016 12.68570622 13.082563 10.47537819 11.77287923 10.38714908 10.98342673 PC(40:7) 3.576277924 2.888745896 3.075528839 1.497922237 3.249717803 3.066086868 2.021569985 1.739818737 2.67780735 3.159911752 3.221093025 2.496735149 2.603453917 1.319248236 2.529096915 0.871857016 3.006088245 1.50275215 2.276251338 2.04803226 1.737705723 3.874842706 2.517453074 2.001567288 2.82335083 2.583712209 1.962743189 2.528998955 PC(40:8) 1.815254658 1.138886031 2.142672918 0.764930182 2.776114763 1.613844429 1.28416221 0.608968399 1.851053551 1.401216961 2.407756044 1.222503606 2.267265707 1.455459603 2.653257096 1.146666048 2.493720016 2.010042106 1.999286515 2.559144772 1.137254611 3.189198152 1.9938472 1.273759713 2.418142884 2.716230511 1.336901468 1.949487483 PC(O-32:0) 2.063938368 1.082251504 2.359813919 1.319592419 2.480948633 2.104524202 3.26339494 1.097297373 3.358583418 1.309781 2.292173061 1.759810984 2.352325894 5.618958396 1.887563511 2.343419889 2.870602882 2.496988359 2.062737878 2.245358579 2.248417442 4.233784308 3.713796401 5.284803843 3.682771487 4.774637266 2.760152323 3.805418563 PC(O-32:1) 1.552624649 0.921868685 1.62980376 0.946567508 1.404616076 1.244592763 1.980284377 0.66238249 2.262994852 0.976081617 1.758226109 1.139705745 1.676543617 1.080724814 1.150754528 1.024665962 1.556784127 1.277285691 1.406884267 1.205336838 1.335341225 2.089779316 2.009705558 1.147624835 2.118000894 2.036115137 1.499051974 1.586501304 PC(O-32:2) 0.242013742 0.135530833 0.189980049 0.096158911 0.159527612 0.123386039 0.238723767 0.090788034 0.266152464 0.107931577 0.279495552 0.116619973 0.186977208 0.10051883 0.128957507 0.088795399 0.166950838 0.104285421 0.207486717 0.142449938 0.157333091 0.184394276 0.226813028 0.11732505 0.233447383 0.214769953 0.170968458 0.158270206 PC(O-34:1) 8.730306571 5.564849797 9.803784246 4.850254081 10.31667611 8.108453324 11.26584847 3.503438984 14.26543204 5.855397279 10.64376467 8.176197489 10.32461672 6.530727073 7.119366889 6.739578271 11.3571984 7.728269963 8.816252371 6.633830368 8.969959245 10.8789588 12.83602805 6.005859359 12.44984423 12.2514228 10.77131234 10.15997208 PC(O-34:2) 4.569079992 2.651286916 3.697884858 2.502474498 4.015004599 3.747918917 5.266340605 2.211072714 5.843038275 3.1204388 4.821702778 2.245025676 3.717212089 2.28103068 2.771781256 3.697474854 4.406626283 3.47356271 3.805186615 3.612504522 3.559401803 3.934598862 4.815409669 2.585266647 4.912313068 4.849468902 4.141609409 3.871430441 PC(O-34:3) 0.297950523 0.165598236 0.231619512 0.200862218 0.245298516 0.226068749 0.308709148 0.149256961 0.366795496 0.181524598 0.309077198 0.134824229 0.255180561 0.122086654 0.194576884 0.185452111 0.223231869 0.194127196 0.258012803 0.177243088 0.185465949 0.244285321 0.286395645 0.163174741 0.268729513 0.277161224 0.233392909 0.229284423 PC(O-36:2) 2.913032934 2.249559807 2.406438388 2.247658553 2.94932811 3.760863029 3.322931705 1.74674426 4.020130017 2.843618339 3.111595208 2.141039256 2.693428885 1.828302908 2.038561882 2.110575293 3.331015232 2.517370374 2.539532802 2.128822487 2.641426999 3.068269499 3.463738451 1.957260925 3.387474692 3.396409035 3.014242465 3.060228358 PC(O-36:3) 2.234498679 1.671665198 1.751830735 1.922544683 1.546877278 2.710140241 2.540786823 1.849096636 3.296890085 2.166413743 2.165304515 1.397576666 2.128965086 1.260293907 1.601860992 2.551789995 2.680379216 2.210037269 1.647476093 1.816595621 2.069774388 2.241625898 2.496622809 1.744601403 2.515064554 2.630982343 2.27773121 2.374407672 PC(O-36:4) 24.61157729 12.31797457 23.18632637 9.851930023 27.11565455 16.29101804 27.85842242 9.013966169 31.89779665 15.81616362 27.96858454 11.71644431 20.52782975 16.60493943 17.73189206 25.3290373 27.60392622 25.24258882 20.49118956 24.9805669 20.97523951 31.43747054 29.91530461 17.51503203 27.54184848 32.79535913 22.76812047 26.60174213 PC(O-36:5) 1.59851858 0.808004584 1.403719072 0.656333662 1.394760954 1.043179467 1.786306475 0.565544574 1.902697329 0.87794545 1.701138105 0.690004273 1.297545084 1.323350544 1.113315252 1.0641597 1.419082124 1.21545003 1.31216207 1.807986202 1.099358597 2.005574395 1.646608672 1.245433221 1.631270091 2.202544484 1.244030124 1.941319107 PC(O-38:4) 12.51161023 7.110293323 11.30599384 5.141866056 14.31823874 10.38567447 13.67320312 5.644778846 15.6507849 10.56942906 14.11223904 5.45099728 8.848156391 9.327322076 7.341318727 12.79758073 13.48674068 15.16701571 9.220082017 9.054907691 10.97909432 15.23134491 13.83874537 8.91930819 11.4058834 15.15567964 11.11098654 13.42086388 PC(O-38:5) 26.6501243 14.30189815 24.17541022 12.70916923 27.14664769 16.42375865 31.5391175 14.05845342 36.74143148 18.62125577 28.72057742 10.12620812 24.73233798 16.49820573 20.00495263 29.44420991 31.88096016 28.09921247 20.87318648 21.1203946 25.41873423 30.93588303 32.35220562 20.04023751 31.31466256 34.55576547 27.33142767 28.12330801 PC(O-38:6) 1.516849364 0.853438215 1.309627081 0.824327517 1.284404481 1.107138613 1.841636653 0.878387164 2.114108143 1.143513935 1.570465317 0.646101843 1.360445648 1.014621155 0.90240062 1.339455384 1.562298695 1.220047477 1.011810454 1.194704539 1.129668604 1.966692427 1.503498368 1.336103718 1.490629343 1.969808624 1.266990076 1.839056101 PC(O-40:5) 4.685918133 2.530177236 3.936835261 1.380092257 4.452669526 2.305611175 4.986534774 1.657030876 5.324409315 2.482717578 4.454306473 1.892745153 3.085619722 2.246001391 2.491624091 2.86732023 4.154145579 3.522027463 2.617539317 2.427784436 3.14992755 4.329556024 4.421891341 2.317209935 4.229303061 4.421697171 3.513172216 3.617640889 PC(O-40:6) 1.65555439 0.880250358 1.285508449 0.60169087 1.012082733 0.742673005 1.458464144 0.85964049 1.441492322 0.977574598 1.281156115 0.60014356 0.999640425 0.62121718 0.74945648 1.062886916 1.16524981 0.844819184 0.723436515 0.797803494 0.9056603 1.01625931 1.058799202 0.767483955 1.034530583 1.178677202 0.959393263 0.973461496 PC(P-30:0) 0.041687303 0.017501399 0.042042662 0.007200721 0.027475941 0.01867288 0.058993979 0.007602155 0.055308333 0.014820564 0.050264176 0.014987838 0.025953488 0.04637819 0.033581286 0.044023351 0.045846603 0.038963363 0.042945278 0.051751476 0.028166876 0.042254211 0.042183933 0.04366331 0.048289367 0.040762718 0.042692202 0.03647275 PC(P-32:0) 0.638573686 0.318175432 0.569536947 0.25261094 0.695082109 0.38730816 0.760951089 0.339788446 0.823769265 0.377359963 0.640032855 0.396680336 0.508550414 1.111135936 0.480839737 0.767151818 0.738519575 0.622762498 0.575800278 0.742965221 0.497852928 0.823265813 0.65194305 1.206046215 0.721218765 0.934953406 0.549474922 0.82706393 PC(P-32:1) 0.263160574 0.11221897 0.17469514 0.077829803 0.265391821 0.141623823 0.281434186 0.082151031 0.310580469 0.141687505 0.280902527 0.124047575 0.190857298 0.107814552 0.14449011 0.152472032 0.214527502 0.160604146 0.217493384 0.248620492 0.147740025 0.202806726 0.201187602 0.123176834 0.220537701 0.203939889 0.164213574 0.182965297 PC(P-34:1) 2.800136138 0.930199351 2.202346373 0.684481935 3.951103012 1.228820525 3.779244535 0.924119497 4.194517493 1.097668505 3.530662665 1.273502047 2.070631387 1.571503335 1.822279611 2.280679127 3.687569888 2.416954471 3.239696236 2.734177562 1.983689633 2.399621052 2.783474404 1.522910663 2.955374284 2.959007072 2.344776834 2.21388326 PC(P-34:2) 5.246233382 2.100027855 3.215365591 1.638112351 5.092660458 2.487553915 6.523736713 2.161121385 7.0453145 2.731280649 6.245948235 2.413738336 3.348043117 2.122539113 2.974912813 3.680217401 4.141278254 3.055501536 5.193080958 4.910940664 3.724082775 3.607862186 4.889205296 2.511958586 5.12855838 4.355327509 4.327751401 3.402730275 PC(P-34:3) 0.328344357 0.150197005 0.226634505 0.091094289 0.229349237 0.11859998 0.283605328 0.093574164 0.337856846 0.142197303 0.357688179 0.132436785 0.203273584 0.140731275 0.21094818 0.197655863 0.26437487 0.204586388 0.262978232 0.235549243 0.237649508 0.295408533 0.286745719 0.152821585 0.286321801 0.321618162 0.219816589 0.230677479 PC(P-36:2) 1.395842492 0.776887096 1.220043589 0.729512281 1.695881946 1.332409685 1.718220842 0.637585934 1.958383451 0.96639545 2.100789309 0.858219549 1.103238818 0.786930774 0.830910389 0.982214873 1.569975838 1.118712084 1.366554368 1.106483135 1.181137786 1.209826089 1.40334216 0.8532994 1.519895626 1.386974376 1.203966671 1.174314904 PC(P-36:4) 8.797347333 4.109573477 8.261364711 3.578000374 11.370617 6.741018392 11.94619594 3.085559296 13.82288982 4.858778074 12.99098562 6.224131002 7.597086158 6.062302446 6.233673043 9.331602816 9.440021046 9.478977751 8.314402876 10.73397251 8.166829093 12.34510912 12.08945996 6.98121025 11.15090904 12.38896146 9.385562743 10.32707553 PC(P-36:5) 0.408762954 0.214742164 0.280406593 0.152248738 0.318950753 0.289592798 0.440232815 0.16211296 0.424635017 0.184037176 0.46528658 0.297999346 0.194952948 0.409395607 0.168443195 0.214314359 0.251777867 0.215275452 0.317787475 0.713469167 0.198766973 0.467291786 0.266756486 0.356637286 0.255949903 0.642225939 0.214991672 0.639032974 PC(P-38:4) 2.612505377 2.058584542 3.07545553 1.900852535 3.914224658 3.512024244 3.636390225 1.592671275 4.135544605 3.036941126 3.962639115 2.313399399 2.398542073 2.26223867 1.811141762 2.898316263 3.136383426 3.727571652 2.103143585 2.504497043 2.92251745 4.269968481 3.602332799 2.720307813 3.034165621 3.866837956 3.144182486 3.943711073 PC(P-38:5) 3.476152602 1.865474107 3.034952356 1.29030719 3.579150506 2.416560714 4.036287306 1.327988931 3.978233199 1.924889027 4.102527589 1.885450187 2.408500969 1.937787861 1.945030787 2.499597969 2.991815246 2.770421515 2.514667752 3.078260091 2.409560545 3.734793433 3.168871013 2.350262868 3.143231302 3.603758973 2.502335349 3.035913191 PC(P-38:6) 0.395915685 0.283347648 0.358443932 0.291784241 0.496377775 0.398149308 0.574504333 0.233995112 0.570726085 0.319716344 0.663529335 0.420753723 0.367530712 0.315042522 0.351613848 0.370417569 0.45068076 0.423003429 0.441430454 0.485998947 0.366339472 0.421968833 0.409271664 0.363228581 0.421629582 0.465440146 0.388954906 0.438211226 PE(34:1) 0.240760628 0.169488595 0.375633275 0.242435268 0.614703527 0.386936792 0.313711937 0.160819562 0.284204519 0.132331326 0.289438797 2.305867315 0.418352513 1.424979811 0.576595557 0.568346631 0.318955525 0.406806048 0.356775869 1.553081908 0.237474707 1.256940181 0.352671185 0.51484913 0.188350635 1.023982245 0.280384284 1.668554995 PE(34:2) 1.257536914 1.211471593 1.259234523 1.893475454 2.098157795 2.666595678 1.087274912 0.788112735 1.074472817 1.069851065 1.323387792 7.974560903 2.196652098 1.972798574 2.221901054 1.839153972 1.798282989 2.006937204 1.560650728 2.828396445 1.1750985 1.448592446 1.366305769 0.495010556 0.872990246 1.209039277 1.331709106 1.74099703 PE(36:1) 0.455279181 0.652511517 0.588108552 0.469668325 0.817033987 0.835202459 0.465306898 0.423362342 0.48247368 0.577860618 0.335447854 3.016751751 1.215271852 3.482411692 1.354930312 0.938361694 1.110147859 1.063606933 0.736459478 2.259335641 0.73555784 2.131820327 0.839895633 0.961980052 0.386097447 1.297642341 0.715607651 2.619456207 PE(36:2) 2.744587852 3.49232619 3.199869452 5.31917381 4.161837753 6.682830113 2.397460666 2.834202588 2.65725609 3.810644391 3.056256194 16.93361368 7.409179728 7.189810119 8.890835735 6.042560032 6.274096506 7.215368221 5.615808147 8.547505842 4.120162558 3.990266535 5.221138734 1.406440398 3.582933058 4.030878629 4.194604693 4.643852845 PE(36:3) 1.073842386 1.032588712 1.170052444 1.434208642 1.722984498 2.277641489 1.064672064 0.941666353 0.96494736 1.233294772 1.564307947 4.254348174 2.172539561 1.000855881 2.884824368 1.71770865 1.920255756 1.862441009 1.925224977 1.867079806 1.576397706 0.913459498 1.586784274 0.283081181 1.178793091 0.896124659 1.262891736 0.973589102 PE(36:4) 1.873184333 1.324985895 2.165439525 1.077356729 2.286424927 1.452929496 1.64572113 0.739188711 1.609743385 0.962824475 1.970860707 5.112641267 3.132821337 1.848912262 2.743099119 1.968462659 2.192248504 2.550850437 1.669340644 3.183455606 1.483390714 2.325546751 2.581062072 0.658297276 1.265067078 1.75075168 1.888757817 2.412080933 PE(38:3) 0.326151508 0.582445794 0.143431086 0.256437305 0.406021887 0.607236571 0.295785541 0.257698817 0.247696034 0.576616123 0.286929212 1.759712938 PE(38:4) 6.547606078 6.148952266 8.594357818 6.359325126 10.64230999 8.283836567 7.729784186 3.637816003 7.531981433 5.910522674 7.814847508 20.69695316 16.42787128 9.735511084 13.53914691 8.611259641 15.04309052 12.48496382 7.931439505 12.63672461 8.949916537 8.536407607 11.09946393 3.386482623 7.134687893 7.403402846 9.117836541 10.16934913 PE(38:5) 2.110612634 1.509740206 2.960269671 0.898930772 3.785757145 1.619969988 1.636757932 0.699952613 1.867549461 1.371433742 2.344788864 4.549518987 4.023779569 1.818658726 3.821041974 1.777994457 2.970395622 2.131318872 2.398976541 3.039982721 1.803013729 2.203171387 2.520631133 0.572266539 1.694728618 1.693926087 1.748333183 2.174853171 PE(38:6) 0.837663708 0.532734358 0.65756372 0.264438469 0.902321266 0.738770871 0.421270315 0.201508849 0.586382447 0.358414626 0.59268031 1.145686949 0.655860999 1.141783742 0.865585804 0.510681946 0.896206321 0.72740698 0.388456786 2.396528568 0.335674983 1.242835902 0.636885446 0.528583527 0.420265363 1.090901859 0.493811128 1.516904362 PE(40:4) 0.271584653 0.238380032 0.519064361 0.136819904 0.686834789 0.227965889 0.35502059 0.075565818 0.24432602 0.127353345 0.296131023 1.182097241 1.050100975 0.573476825 1.047012589 0.75007776 1.074925776 0.652695879 0.3450783 0.533796426 0.232281423 0.397823641 0.605725743 0.130286015 0.363461203 0.224311554 0.31897781 0.337134084 PE(40:5) 0.887232072 0.716705812 1.439242592 0.363252844 1.47256653 0.367569778 0.840592109 0.320185936 0.97056405 0.527665977 1.00216092 1.978881685 1.346082364 0.796165823 1.723785276 0.485781287 1.941780362 0.978222818 0.516155253 0.923153818 0.942817077 0.818048197 1.372915403 0.276023227 0.597511425 0.579097662 0.705843025 0.791289916 PE(40:6) 0.124962264 0.165965737 0.254805941 0.070410243 0.207320673 0.187214464 0.139514128 0.087191329 0.14771895 0.140627961 0.177344003 0.49666466 0.411118752 0.686257409 0.219743383 0.192215617 0.395270037 0.279961377 0.121849682 0.816394533 0.128415746 0.449262778 0.126055162 0.261907319 0.193048724 0.355159961 0.117175522 0.603418266 PE(O-18:1/20:3) 1.16589792 0.525688643 0.928808754 0.260037829 1.329664972 0.65202279 0.870989042 0.303232066 1.199163338 0.470419197 1.158591715 0.640891835 0.900000434 0.398082911 0.819421228 0.780220664 1.0612283 1.229038656 0.957251102 1.243914748 0.575510274 0.895621733 1.221838054 0.267629985 0.895199391 1.085667922 0.763035839 0.929805455 PE(P-16:0/18:1) 0.18506372 0.237624287 0.20912553 0.185662812 0.241336491 0.308285915 0.330943737 0.481624467 0.193567853 0.603580186 0.224727556 0.165957296 0.347658542 0.519655101 0.186457874 0.534160497 PE(P-16:0/20:4) 0.863905783 0.81104011 0.951823484 0.580884504 1.376845169 1.91128215 1.96060218 0.643762646 1.380582428 0.986469885 1.381108246 0.72573135 1.042867214 0.699469396 0.86927897 1.636017013 1.496938505 1.678126261 1.014764152 1.939057785 1.092478075 1.395079152 1.703397102 0.595538712 1.163844628 1.499896592 1.239642624 1.602879524 PE(P-16:0/22:5) 1.133824273 1.180548732 1.265399183 0.556480954 1.43854235 1.000225554 1.270046214 1.189677244 1.652430229 1.324142924 1.554269607 0.903894332 1.08626978 0.581327426 0.788029316 0.761435956 1.316262267 1.425668421 1.251152536 1.570472561 1.07170494 1.258599508 1.002775899 0.580469026 0.935346692 1.266612576 1.024355852 1.230320489 PE(P-16:0/22:6) 1.000114651 0.654077232 0.891409818 0.353251389 0.867389774 1.196720046 0.649637017 0.40156451 0.898670417 0.858701708 0.94485873 0.720782379 0.582920576 1.037811149 0.477341718 0.575773144 0.637258789 0.791034566 0.556609348 1.77336351 0.731308789 1.873380151 0.763412726 0.59477569 0.585125556 1.354841787 0.672364304 1.21280703 PE(P-18:0/18:1) 0.343229684 0.460320063 0.662495448 0.681699171 0.674132429 1.041783937 0.645739975 0.393814169 0.486405363 0.587401748 0.44670612 0.63311488 0.563027733 0.515841926 0.459799179 0.439037943 0.759231556 0.616571831 0.608273613 0.636691121 0.74405594 0.675760909 0.446150294 0.374834583 0.467673346 0.730881814 0.621216259 0.909505764 PE(P-18:0/18:2) 0.803923897 1.547708782 1.085802092 2.634383238 1.157275791 3.867350518 0.992966479 1.596570113 1.305318781 2.768587052 1.130568016 1.751582485 0.892766673 0.907989017 0.571979099 0.876328472 1.495633984 1.822622456 1.054730848 1.146333863 1.438539626 1.634022235 1.286990161 0.674511494 1.078851938 1.505878234 1.293115581 2.290282786 PE(P-18:0/20:4) 3.632236465 4.009403403 4.744322239 4.880309966 6.130703662 9.81181324 10.05164222 3.428072417 5.635786853 5.673238917 5.136702111 3.895547726 7.194578151 3.685569927 4.048171689 5.823696341 6.864392518 7.901314645 4.410471092 5.998325989 6.798480674 7.914574824 6.988271593 2.907114019 5.049590838 7.363400619 5.242209657 7.963449376 PE(P-18:0/22:5) 1.482468988 1.974365983 2.544360618 0.956139095 2.230171615 1.934280478 1.78172792 1.651791288 2.270266141 2.034334867 2.064133614 1.453583689 2.010382751 1.112679075 1.40201818 1.046264552 1.840027679 1.828779964 1.46024659 1.242465527 2.396936554 2.050513305 2.084867407 0.878238382 1.667394285 2.169092729 1.841329629 2.067782252 PE(P-18:0/22:6) 0.694790186 0.910071552 0.821543672 0.467267976 0.729932085 1.304045579 0.628982691 0.507647293 0.941918931 0.952453682 0.836528314 0.609784013 0.558205226 0.594922369 0.412711311 0.402342235 0.4474509 0.71221846 0.500071095 0.719296722 0.825260015 1.373507901 0.807791697 0.535450725 0.528321396 0.91930352 0.732347012 1.485459743 PE(P-20:0/20:4) 0.073311195 0.044622863 0.099045535 0.086412571 0.101618886 0.202143204 0.142631763 0.061518327 0.126937196 0.117812215 0.119623549 0.109937871 PI(32:1) 0.558366411 0.574251019 0.766976405 0.288424561 0.66323183 0.674563838 0.24804277 0.207792663 0.406523919 0.325277025 0.687243428 0.69733187 0.472446433 0.263968076 0.847553164 0.232342007 0.694671399 0.281326335 1.192618683 0.408852882 0.42141926 0.339409486 0.629245553 0.173050534 0.488439865 0.31039568 0.346753312 0.291237561 PI(34:1) 5.081631402 4.03604794 4.275550378 3.183554116 4.038522494 5.942586191 2.471746206 3.00247247 4.425492098 3.346624883 5.653432365 7.401994288 3.950456341 2.720468141 6.142122826 1.129562086 4.777244182 3.224960431 8.689935124 2.497273406 4.006063086 2.687401677 5.92016877 2.2654996 5.10834039 2.244802509 4.073906863 2.758370411 PI(34:2) 8.274426874 7.242622187 6.009252511 4.353578279 7.036649996 7.81265033 4.29238014 4.76213439 6.292858069 7.536655806 7.670072017 10.01074951 5.816117147 4.152095712 9.034705719 2.967840359 9.066564406 5.984703166 13.82199106 5.061598684 5.600575959 4.358214557 8.997604416 2.661565964 7.645759037 4.135989688 6.495845382 3.886725361 PI(36:1) 2.660939039 3.220149921 2.422913534 3.713602272 2.202249306 6.206545954 1.448569778 2.279143579 3.04231925 2.850352426 2.766077056 3.42500053 2.581366891 2.479984769 3.170411524 0.474912908 3.062618746 1.941837877 3.755650123 1.386828977 3.003257256 1.823301199 3.558980474 2.472672775 2.942982434 0.794979652 2.669111393 2.107279109 PI(36:2) 33.53015151 29.90178 25.52674354 24.98083216 23.48160309 36.42505063 14.81683488 32.76022305 26.39265657 37.1600073 28.85800459 26.125722 27.56272592 22.37528683 41.07291868 15.84017208 48.29068874 28.94779376 59.16547323 20.08612441 27.68122509 18.01985627 40.04308275 19.41334515 37.63631939 18.11427276 34.76957699 22.80496842 PI(36:3) 5.913381961 5.696352895 4.130693999 4.105424317 5.205171255 7.256798554 3.096813987 4.951515045 5.441801896 6.901529916 5.956627995 6.1834986 3.673019712 1.932321466 7.114523033 1.65123565 7.657925181 2.796795472 11.89622153 3.908633556 4.257194563 2.897278074 8.30361334 1.640324078 6.82581486 3.126221464 5.772108981 2.706527076 PI(36:4) 14.57054664 9.342778986 12.29449454 4.990289102 12.89066974 8.347552918 7.307340013 4.500420846 11.23724655 7.46465773 15.16755575 9.084399177 14.08895574 6.774867484 17.85312713 4.95078441 18.73131807 7.85655254 25.54441389 8.74618086 14.67055048 7.681804063 20.77724303 3.771770448 17.04602228 8.581065369 14.53163111 7.791748371 PI(38:2) 0.964300449 2.67848052 0.600772771 2.379230529 0.639259595 5.248469778 0.529571315 1.194150242 0.423049282 1.182825545 0.970226016 2.14190989 PI(38:3) 12.81757435 12.83444239 5.489294351 10.63796852 5.219554596 14.63230917 3.947600689 14.20617942 5.620275812 14.75703435 8.996358543 5.462677657 4.843078537 2.594590126 6.495563046 1.245002455 9.879771003 3.27024711 5.181998095 1.864369144 9.295304816 6.342202372 10.1893267 6.268816537 8.067192711 3.134079583 9.013807895 4.347216165 PI(38:4) 211.1304352 126.9990746 169.3477803 96.11285926 173.9585174 143.7267891 119.6384694 85.6329347 162.4724072 134.1414165 190.7100513 76.44078551 198.8396358 106.4871642 209.867879 49.55022094 228.9824381 95.47941362 232.1431267 77.05568504 178.5527603 104.6201046 204.6262025 80.16992533 189.0632574 91.44885369 172.295497 97.27182071 PI(38:5) 13.51014752 6.171501492 11.36283931 3.192261273 11.18704292 4.918869228 7.590108771 4.506996563 9.649159208 5.509138542 13.37170471 4.733048311 10.48428998 4.031854027 13.44831245 2.485621098 12.54267803 3.485701913 18.68635705 5.841689983 7.92784232 5.161647639 12.2146476 2.276467592 10.64516774 5.454843904 7.850850632 5.531988863 PI(40:4) 1.512725618 1.675238197 1.895331355 0.773848539 1.510250794 1.396612501 1.035578566 0.720698604 1.579824662 0.592698452 1.211227671 1.222899889 2.028504045 1.394991433 2.741359715 0.694103481 1.645709623 1.128049989 2.17548031 0.446467348 1.976370325 1.136283931 1.930225908 0.890844652 1.345413779 0.950832335 1.863576775 1.047540339 PI(40:5) 12.88716304 8.521450697 11.22103254 4.019441146 8.840960203 4.997079528 6.867064095 6.847951883 7.684293598 6.362830022 10.68337013 3.715677815 9.185564896 2.528832954 8.296173917 1.746218232 7.894995579 3.729975512 7.31752468 1.738442456 6.273126696 4.797643263 7.020842663 4.338450014 6.081693478 2.43077798 5.233307681 3.308824651 PS(38:4) 0.414401306 0.201488581 0.207146624 0.239728789 0.170229273 0.218062255 7.261099375 0.352153366 0.336540734 0.171135895 0.367591764 0.399651879 1.23742079 0.185256955 0.267807638 0.993638233 1.074597774 0.298117254 0.560777013 0.321910616 0.349728067 0.390358239 0.404255561 0.267891377 0.121041315 0.330177599 0.132199613 0.363866578 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name CE(16:0) CE(16:1) CE(17:0) CE(17:1) CE(18:0) CE(18:1) CE(18:2) CE(18:3) CE(20:1) CE(20:2) CE(20:3) CE(20:4) CE(20:5) CE(22:4) CE(22:5) CE(22:6) CE(24:4) DG(16:0_20:4) DG(18:0_18:2) DG(18:0_20:4) DG(18:1_18:2) DG(18:1_20:4) DG(18:2_18:2) DG(18:2_20:4) LPC(14:0) LPC(15:0) LPC(16:0) LPC(16:1) LPC(17:0) LPC(17:1) LPC(18:0) LPC(18:1) LPC(18:2) LPC(18:3) LPC(19:0) LPC(20:1) LPC(20:2) LPC(20:3) LPC(20:4) LPC(20:5) LPC(22:0) LPC(22:1) LPC(22:5) LPC(22:6) LPC(24:0) LPC(O-16:0) LPC(O-18:0) LPC(O-18:1) LPC(O-20:0) LPC(O-20:1) LPE(16:0) LPE(18:0) LPE(18:1) LPE(18:2) LPE(20:4) PC(29:0) PC(31:0) PC(31:1) PC(32:0) PC(32:1) PC(32:2) PC(32:3) PC(33:1) PC(33:2) PC(34:0) PC(34:1) PC(34:3) PC(34:4) PC(35:1) PC(35:2) PC(35:3) PC(35:4) PC(36:1) PC(36:2) PC(36:3) PC(36:4) PC(36:5) PC(37:4) PC(37:5) PC(38:2) PC(38:3) PC(38:4) PC(38:5) PC(38:6) PC(38:7) PC(39:5) PC(39:6) PC(40:4) PC(40:5) PC(40:6) PC(40:7) PC(40:8) PC(O-32:0) PC(O-32:1) PC(O-32:2) PC(O-34:1) PC(O-34:2) PC(O-34:3) PC(O-36:2) PC(O-36:3) PC(O-36:4) PC(O-36:5) PC(O-38:4) PC(O-38:5) PC(O-38:6) PC(O-40:5) PC(O-40:6) PC(P-30:0) PC(P-32:0) PC(P-32:1) PC(P-34:1) PC(P-34:2) PC(P-34:3) PC(P-36:2) PC(P-36:4) PC(P-36:5) PC(P-38:4) PC(P-38:5) PC(P-38:6) PE(34:1) PE(34:2) PE(36:1) PE(36:2) PE(36:3) PE(36:4) PE(38:3) PE(38:4) PE(38:5) PE(38:6) PE(40:4) PE(40:5) PE(40:6) PE(O-18:1/20:3) PE(P-16:0/18:1) PE(P-16:0/20:4) PE(P-16:0/22:5) PE(P-16:0/22:6) PE(P-18:0/18:1) PE(P-18:0/18:2) PE(P-18:0/20:4) PE(P-18:0/22:5) PE(P-18:0/22:6) PE(P-20:0/20:4) PI(32:1) PI(34:1) PI(34:2) PI(36:1) PI(36:2) PI(36:3) PI(36:4) PI(38:2) PI(38:3) PI(38:4) PI(38:5) PI(40:4) PI(40:5) PS(38:4) METABOLITES_END #END