#METABOLOMICS WORKBENCH efahy_20191217_103517_mwtab.txt DATATRACK_ID:1874 STUDY_ID:ST001289 ANALYSIS_ID:AN002142 PROJECT_ID:PR000871 VERSION 1 CREATED_ON December 17, 2019, 11:05 am #PROJECT PR:PROJECT_TITLE Regulated accumulation of desmosterol integrates macrophage lipid metabolism and PR:PROJECT_TITLE inflammatory responses PR:PROJECT_SUMMARY Inflammation and macrophage foam cells are characteristic features of PR:PROJECT_SUMMARY atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to PR:PROJECT_SUMMARY inflammation and LXR-dependent response pathways are poorly understood. To PR:PROJECT_SUMMARY investigate this relationship, we utilized lipidomic and transcriptomic methods PR:PROJECT_SUMMARY to evaluate the effect of diet and LDL receptor genotype on macrophage foam cell PR:PROJECT_SUMMARY formation within the peritoneal cavities of mice. Foam cell formation was PR:PROJECT_SUMMARY associated with significant changes in hundreds of lipid species and unexpected PR:PROJECT_SUMMARY suppression, rather than activation, of inflammatory gene expression. We provide PR:PROJECT_SUMMARY evidence that regulated accumulation of desmosterol underlies many of the PR:PROJECT_SUMMARY homeostatic responses observed in macrophage foam cells, including activation of PR:PROJECT_SUMMARY LXR target genes, inhibition of SREBP target genes, selective reprogramming of PR:PROJECT_SUMMARY fatty acid metabolism and suppression of inflammatory response genes. These PR:PROJECT_SUMMARY observations suggest that macrophage activation in atherosclerotic lesions PR:PROJECT_SUMMARY results from extrinsic, pro-inflammatory signals generated within the artery PR:PROJECT_SUMMARY wall that suppress homeostatic and anti-inflammatory functions of desmosterol. PR:INSTITUTE University of California, San Diego PR:DEPARTMENT Bioengineering PR:LAST_NAME Fahy PR:FIRST_NAME Eoin PR:ADDRESS 9500 Gilman, La Jolla, CA, 92093, USA PR:EMAIL efahy@ucsd.edu PR:PHONE 858-534-4076 #STUDY ST:STUDY_TITLE Regulated accumulation of desmosterol integrates macrophage lipid metabolism and ST:STUDY_TITLE inflammatory responses ST:STUDY_SUMMARY To investigate the relationship between hypercholesterolemia, foam cell ST:STUDY_SUMMARY formation and inflammation, we performed lipidomic and transcriptomic analyses ST:STUDY_SUMMARY of elicited peritoneal macrophages in wild type (WT) or LDL receptor knockout ST:STUDY_SUMMARY (LDLR KO) mice fed either a normal cholesterol, normal fat (NCNF) diet or a high ST:STUDY_SUMMARY cholesterol, high fat (HCHF) 'Western' style diet. The combination of the LDLR ST:STUDY_SUMMARY KO genotype and the HCHF diet results in the formation of macrophage foam cells ST:STUDY_SUMMARY in the elicited peritoneal macrophage population. Analysis of macrophages from ST:STUDY_SUMMARY the above four experimental groups revealed massive reprogramming of the ST:STUDY_SUMMARY lipidome in response to both diet and genotype. These studies confirmed and ST:STUDY_SUMMARY extended prior knowledge regarding the roles of SREBP and LXR signaling in ST:STUDY_SUMMARY cholesterol and fatty acid homeostasis. Unexpectedly, peritoneal macrophage foam ST:STUDY_SUMMARY cells exhibited a strongly 'deactivated' phenotype, with marked suppression of ST:STUDY_SUMMARY pro-inflammatory mediators that are normally characteristic of the inflammatory ST:STUDY_SUMMARY responses associated with atherosclerotic lesions. Many of these changes in gene ST:STUDY_SUMMARY expression and lipid metabolism appear to be related to the paradoxical ST:STUDY_SUMMARY accumulation of high levels of desmosterol, the last intermediate in the Bloch ST:STUDY_SUMMARY pathway of cholesterol biosynthesis. WT or LDLR KO mice were fed either a NCNF ST:STUDY_SUMMARY diet or a HCHF diet for twelve weeks to establish four experimental groups ST:STUDY_SUMMARY (WT-NCNF diet, WT-HCHF diet, KO-NCNF diet, and KO-HCHF diet). As expected, the ST:STUDY_SUMMARY combination of the HCHF diet and LDLR KO genotype resulted in a synergistic ST:STUDY_SUMMARY effect on serum lipid levels. Elicited peritoneal macrophages (92-96% ST:STUDY_SUMMARY F4/80-positive) were immediately prepared for analysis, thereby preserving in ST:STUDY_SUMMARY vivo gene expression and lipid profiles. Macrophages derived from LDLR KO mice ST:STUDY_SUMMARY fed the HCHF diet contained nearly four-fold more total cholesterol than cells ST:STUDY_SUMMARY from WT mice fed the same diet. Quantitative analysis of 245 lipid species ST:STUDY_SUMMARY revealed significant changes in nearly all major lipid classes. Using a two-way ST:STUDY_SUMMARY ANOVA model, we found that 176 (72%) of the lipids analyzed were significantly ST:STUDY_SUMMARY affected by the HCHF diet, 133 (54%) by the LDLR KO genotype, and 114 (46%) by ST:STUDY_SUMMARY interactions between the HCHF diet and LDLR KO genotype. Many of the observed ST:STUDY_SUMMARY interactions (60%) were synergistic. ST:INSTITUTE LIPID MAPS ST:DEPARTMENT Multiple ST:LABORATORY Multiple ST:LAST_NAME Fahy ST:FIRST_NAME Eoin ST:ADDRESS 9500 Gilman, La Jolla, CA, 92093, USA ST:EMAIL efahy@ucsd.edu ST:PHONE 858-534-4076 ST:PUBLICATIONS Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, ST:PUBLICATIONS Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy ST:PUBLICATIONS RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, ST:PUBLICATIONS Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of ST:PUBLICATIONS desmosterol integrates macrophage lipid metabolism and inflammatory responses. ST:PUBLICATIONS Cell. 2012 Sep 28;151(1):138-52. doi: 10.1016/j.cell.2012.06.054. PMID: ST:PUBLICATIONS 23021221; PMCID: PMC3464914. #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - 5_1 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_2 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_3 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_4 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_5 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_6 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_7 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_8 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 5_9 Genotype:Wild type | Diet:Normal SUBJECT_SAMPLE_FACTORS - 6_1 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_2 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_3 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_4 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_5 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_6 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_7 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_8 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 6_9 Genotype:Wild type | Diet:High fat SUBJECT_SAMPLE_FACTORS - 7_1 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_2 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_3 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_4 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_5 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_6 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_7 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_8 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 7_9 Genotype:LDLR-KO | Diet:Normal SUBJECT_SAMPLE_FACTORS - 8_1 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_2 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_3 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_4 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_5 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_6 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_7 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_8 Genotype:LDLR-KO | Diet:High fat SUBJECT_SAMPLE_FACTORS - 8_9 Genotype:LDLR-KO | Diet:High fat #COLLECTION CO:COLLECTION_SUMMARY Male WT C57BL6 or LDL receptor knockout mice (Jackson Laboratory) were fed a CO:COLLECTION_SUMMARY normal cholesterol/normal fat (NCNF) diet or a high cholesterol/high fat (HCHF) CO:COLLECTION_SUMMARY diet (Harlan Teklad, catalog # 96121 including 21% milk fat and 1.25% CO:COLLECTION_SUMMARY cholesterol) for 12 weeks in an IACUC-approved animal facility. Cells were CO:COLLECTION_SUMMARY harvested from the peritoneal cavity 4 days after i.p. administration of 3% CO:COLLECTION_SUMMARY thioglycollate medium. Cells were immediately counted, aliquoted, pelleted and CO:COLLECTION_SUMMARY sent for cDNA microarray analysis and lipid measurement. For all other CO:COLLECTION_SUMMARY experiments primary cells were isolated from male 6–8 week-old C57BL6 mice CO:COLLECTION_SUMMARY (Charles River Laboratories). CO:SAMPLE_TYPE Macrophages #TREATMENT TR:TREATMENT_SUMMARY Mouse thioglycollate-elicited macrophages and bone marrow derived macrophages TR:TREATMENT_SUMMARY were obtained and cultured as described previously (Heinz et al., 2010). For TR:TREATMENT_SUMMARY various ligand treatments, cells were in Phenol-red free RPMI-1640 (Invitrogen) TR:TREATMENT_SUMMARY supplemented with either 10% heat-inactivated FBS (Hyclone) or 10% TR:TREATMENT_SUMMARY lipid-deficient FBS (Hyclone) for 24hr before treatment, then treated with TR:TREATMENT_SUMMARY either 1µM GW3965, 0.25-20µM desmosterol, or 0.3-30µg/ml cholesterol for TR:TREATMENT_SUMMARY 12-24hr. 50µM melavonate and 10µM Mevastatin (Sigma) were added to media in TR:TREATMENT_SUMMARY desmosterol response experiments. For TLR repression studies, cells were TR:TREATMENT_SUMMARY cultured in medium containing Phenol-red free RPMI 1640 (Invitrogen) with either TR:TREATMENT_SUMMARY heat-inactivated FBS (Hyclone) or lipid-deficient FBS (Hyclone) for 24hr, then TR:TREATMENT_SUMMARY pretreated with either 20-30µM desmosterol, 50µg/ml cholesterol, 5µM TR:TREATMENT_SUMMARY triparanol, or 50-100µM 9Z-palmitoleic acid for 18hr. Cells were stimulated TR:TREATMENT_SUMMARY with Pam3CSK4 (300ng/ml), PolyI:C (50ng/ml), LPS (100ng/ml), TNFa (30ng/ml), or TR:TREATMENT_SUMMARY KLA (100ng/ml) for 6hr. See Extended Experimental Procedures for additional TR:TREATMENT_SUMMARY details at https://doi.org/10.1016/j.cell.2012.06.054 #SAMPLEPREP SP:SAMPLEPREP_SUMMARY The various extraction procedures and lipidomic analyses for each lipid class SP:SAMPLEPREP_SUMMARY are described in the publication #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY See publication for details publication CH:CHROMATOGRAPHY_TYPE Several CH:INSTRUMENT_NAME Several CH:COLUMN_NAME Several #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Several MS:INSTRUMENT_TYPE Several MS:MS_TYPE Other MS:ION_MODE UNSPECIFIED MS:MS_COMMENTS See publication for details. publication #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS pmol/1E6 cells MS_METABOLITE_DATA_START Samples 5_1 5_2 5_3 5_4 5_5 5_6 5_7 5_8 5_9 6_1 6_2 6_3 6_4 6_5 6_6 6_7 6_8 6_9 7_1 7_2 7_3 7_4 7_5 7_6 7_7 7_8 7_9 8_1 8_2 8_3 8_4 8_5 8_6 8_7 8_8 8_9 Factors Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:Normal Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:Wild type | Diet:High fat Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:Normal Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat Genotype:LDLR-KO | Diet:High fat 10Z-Heptadecenoic acid 0.8 0.4 0.6 0.8 1.1 0.9 1.1 0.8 0.6 5.3 4.5 2.2 8.9 10.6 9.6 7.2 9 7.3 0.8 1.3 0.9 13.2 0.7 0.9 0.6 0.5 1.1 11.9 11.5 11.5 11.9 16.1 12.9 13 14.9 12.5 11(12)-EpETE 1.3 0.3 0.3 0.2 0.3 0.4 0.3 0.5 0.3 0.2 0.2 0.9 0.6 0.2 0.3 0.7 0.3 0.1 0.2 0.2 0.4 0.1 0.2 0.2 0.2 0.1 0.6 11-HETE 0.8 0.4 0.4 0.3 0.5 0.3 0.4 0.3 0.7 0.2 0.5 0.5 0.6 0.6 0.3 0.5 0.8 0.8 0.4 0.4 0.3 0.6 0.4 0.8 0.3 1.7 0.9 0.3 0.4 0.3 0.4 0.4 0.2 0.3 0.5 0.3 11Z,14Z-Eicosadienoic acid 155.8 148.8 178.3 178 251.9 240.4 209.6 204.4 205 48.8 48.1 50 76.1 84.8 83.3 75.5 72.1 69.2 299.6 310.7 309.2 289.9 280.4 306.4 324.8 337.5 303.8 130 107.9 106.2 112.5 139.7 112.1 90.9 106.4 84.8 12-HETE 49.3 44.4 40.3 101.6 97.5 127.1 120.7 131.4 132.3 11.6 13.8 6.3 63.1 67.6 45 105.9 123.4 121.8 160.7 163.7 162.9 156.5 253.5 272.8 193.4 202.1 83.9 31.9 41.7 50.1 48.5 45.3 44.5 64.9 77.4 74.4 12-Oxo-ETE 4.9 1.6 1.1 1.2 1.1 2.2 1.1 2.2 1.1 1.3 1.2 4.3 1.1 1.2 2.2 2.9 1.2 0.9 1 2.3 1 1.2 1.5 2 13,16,19-Docosatrienoic acid 1.3 1.3 1.4 1.7 2.2 2.2 2.1 1.8 2.1 1.7 1.8 1.7 2 2 2.2 2.4 2.2 3 3.1 2.9 3.1 2.8 3.2 3.2 3.3 3.6 3.3 3 3 3.1 3.9 4.1 3.7 2.6 2.7 2.9 13Z,16Z-Docosadienoic acid 50.8 49.7 62.8 58.6 86.2 80.9 80.1 70.5 70.5 20.1 14.3 15.2 20.2 24.7 21.6 22.8 21.8 25.4 109.8 111.2 118.3 103 110.9 116.6 124.7 134.7 112.6 34.9 34.8 43 31.1 48.3 32.7 22 30.1 20.5 14(15)-EpETE 8.8 1.3 1 1.8 1.5 3.8 2.1 5.2 1.6 1.9 2.4 2.3 1.5 3 2 3.3 1.8 0.6 0.8 0.8 3.2 1.1 0.6 1.1 1.2 4.9 15-Deoxy-delta-12,14-PGD2 1.7 1.1 2.4 1.7 4 4.6 2.7 3.2 1.9 2.8 0.8 1.5 5.4 0.3 0.2 0.9 3.2 0.6 3.2 3.3 0.9 2.6 3.6 3.5 4.4 0.8 0.6 2.4 3.3 4.5 2.8 3.2 3.7 4.2 2.9 4.4 15-Deoxy-delta-12,14-PGJ2 1.1 0.1 0.9 0.4 1.6 2 2 1.9 0.9 0.3 1.4 2 0.6 1.9 0.6 1.5 0.4 0.6 18 29.7 9.9 14.8 11.5 10.8 9.6 35.9 43.9 19.9 23.5 15.7 16.7 15.4 25.9 22.5 24.7 19.3 15S-HETE 8.2 8.2 6.2 10.6 9.4 9.8 10.2 9.7 11.2 25.8 27.3 23.8 14.3 20.2 19.4 26.4 21.1 30.7 10.7 16.8 14 11.4 9.7 24.7 16.3 16.7 14 2.3 2.9 2.4 2.2 1.6 3.6 1.9 -0.3 2.9 2,3-Dinor-TXB2 1 1.7 0.8 2.6 3 -0.2 3.3 3.1 0.7 0.9 2.5 1 5.4 2.4 2.2 6.3 6.9 4.5 0.7 1.8 17.1 7.9 0.5 0.1 2.1 1.2 2.9 2.1 4.3 1.7 0.8 2.3 6.3 20-HETE 23.2 13.9 10.2 11.3 10.8 10.7 15.6 12.5 7.6 15.4 12.2 7.4 6.5 15.8 7.6 16.3 3.1 5.7 9.6 9.5 25.9 9.3 34.7 7.6 24.9 7.9 6 9.6 11.8 14 8.7 16 14.5 23.9 17.1 8.6 22R-Hydroxycholesterol 5.2 7.7 9.4 4.1 16.3 22.1 13.7 4.5 1.9 10.2 4.8 8.2 12.4 3.2 4.9 13.6 16.1 5.2 19.9 35.3 3.7 9 4.4 24,25-Epoxycholesterol 0.249 0.131 0.147 0.127 0.032 0.049 0.039 0.069 0.059 0.267 0.271 0.12 0.17 0.161 0.165 0.229 0.211 0.241 0.239 24S-Hydroxycholesterol 0.221 0.185 0.336 0.288 0.308 0.457 0.471 0.385 0.333 0.582 1.101 0.612 0.567 0.54 6.286 5.119 3.169 6.909 9.219 25-Hydroxycholesterol 0.9 0.3 1.5 2.1 1.4 2.2 0.4 1.9 2.8 1.1 1.2 2.2 1.6 2.5 2.8 1.1 0.8 4.9 5.3 2.8 2.7 3.8 4.9 4.1 3.5 2.4 27-Hydroxycholesterol 2.3 0.9 1.4 0.6 0.9 0.7 2.4 1.2 1.9 1.4 5.2 1.4 0.9 1.1 1.4 1.4 0.6 2.3 2.2 1.5 3 3.4 3.9 2.8 3.1 2 4beta-Hydroxy-cholesterol 4 4 4.1 4.8 4.5 4.9 5.5 4.9 5 3 4 3.5 3.3 3.1 5.2 4.9 5.2 5.9 5.3 5.2 5.1 4.9 4.9 5.8 4.9 4.1 5.3 4.6 4.2 3.8 3.7 4 4.3 3.7 3.8 4.5 5,8,11-Eicosatrienoic acid 59.7 55.4 63.3 79.9 108.1 105.7 98.8 81.1 98.7 58.8 65.1 64.8 107.4 110.6 130.8 101.5 102.2 106.6 153 146.9 165.3 149.3 161.4 166 138 147.1 137.9 114.3 116.9 118 159.5 161.1 144 113.9 120.2 107.6 5-HETE 2.1 1.5 1.9 2.6 3.6 2.8 3.1 2.2 3.9 4.5 11.2 7.7 7.4 3.3 5.9 4.6 6.2 5.6 3 2.3 2 3.6 3.8 4 2.2 4.2 3.8 1.5 2 1.6 2.2 2.1 1.6 1.6 2 1.9 7,10,13,16,19-Docosapentaenoic acid 48.3 45.2 50.9 58.9 81.1 77.2 73.3 62.3 74.2 164.1 171.9 170.1 268.5 273.6 324.4 255.9 248.5 250.9 118.7 110 124.3 114.2 122.5 128.7 109.2 116.5 110.9 302.3 304.5 305.1 421.2 417.2 397.5 309.5 340.6 300.3 7alpha-Hydroxy-cholesterol 1.8 4.1 4 4.8 2.4 1.8 2.7 3.7 1 4.5 13.1 3.2 2.6 1.6 7 1.6 2.2 7.8 9.4 3.3 3.1 5.3 5 4.9 8 3.7 3.5 13.5 13.9 6.3 7.8 11.5 12.9 7.8 10.6 7.1 7-Dehydrocholesterol 7-Oxo-cholesterol 8(9)-EpETE 1.7 1.1 0.5 0.7 0.9 1.9 1 1.8 8-HETE 3.7 4.7 5.2 5.3 6.6 2.9 4.9 2.5 8.8 25.5 32.4 15.7 11.5 23.8 15.7 6.1 14.9 15.6 7.2 6.1 2 10.6 8.9 3.4 2.7 22.5 21 6.3 9 2.4 4.7 8.4 10.6 4.4 11.1 2.4 Adrenic acid 169.4 161.8 173 196.7 257.9 261.1 226.3 214.6 245.2 49.8 52.7 52.7 96.9 99.2 116.9 97.2 98.3 101.1 379.3 378.6 383.1 375 377.6 413.6 357.4 364.8 357 123.2 125.3 127.2 151.7 154.7 139.7 115.7 125 112.2 alpha-Linolenic acid 1.2 1.1 1.3 1.4 2 1.8 2.1 1.5 2 1.1 1.2 1.3 2.1 2 2.3 1.5 1.9 1.8 2.8 2.5 3 2.5 2.9 2.7 2.3 2.6 2.4 2.3 2.3 2.4 4.1 3.3 3.7 3.5 3.7 3.3 Arachidic acid 10.6 13.4 15.4 14.2 18.3 17.1 17.8 17.2 17.2 31.8 14.6 17 22.8 24.6 24.7 19.3 19.5 20.6 25.9 30 21.9 23.8 22.7 31.3 22.3 26.6 20.7 29 28.3 30.6 33.2 35.1 34.7 25.4 25.2 22.5 Arachidonic acid 3 2.7 2.2 4.1 3.3 2.6 2.7 2.7 2 2.6 2.4 4.1 4.2 4.1 2.8 4.3 2.6 3.7 3.8 3.1 2.7 5.4 3.8 4.5 2.9 3.5 3.2 2 5.4 3.4 2.3 3.3 1.7 3.5 3.9 3.5 Arachidonoyl-EA 0.8 0.8 0.8 0.8 0.6 0.6 1 0.7 0.7 0.8 0.7 0.9 0.7 0.8 0.7 0.7 1.4 1 1.1 1.3 0.7 0.7 0.7 1 1 0.7 0.8 0.8 1 Behenic acid 1.4 1.5 1.8 2 2.1 2.2 2.4 2.4 2.4 2.4 2.3 2.6 3.5 3.9 4.1 3 3.1 3.3 3.8 3.8 3.4 3.2 3.4 3.9 4.2 3.9 3.8 5.5 5.4 5.8 6.9 7.3 7.1 5.2 5.4 4.9 Bishomo-gamma-linolenic acid 7.2 6.4 7.2 9.6 12.8 11.9 11.3 8.9 10.7 11.8 13.2 12.5 18.8 17.4 20.7 16.4 18.2 17 17.3 16.4 18.2 15.6 16.5 16.7 16.7 17.2 16.4 25 24.4 24.4 34.9 35.5 31.8 29.3 30.3 28.3 CE(14:0) 0.4 0.3 0.7 0.8 0.5 0.4 0.5 0.7 16.2 10.2 18 14.3 26.6 40.8 19.5 26.5 17.8 2.8 4.5 2.5 2.3 2.9 4.2 3.7 2.7 108.5 93.9 75.9 58.6 85.1 72.6 47.4 79.7 87.3 CE(14:1) 0.3 11.3 7.9 10.2 13 19.1 10.8 10.8 12 0.6 30.8 33.7 23.1 39.7 41.1 47.5 20.4 29.1 26.3 CE(16:0) 14.1 20.3 16.3 24.1 55.8 38.2 22.6 26.8 38.5 145.7 176.8 228.5 101.1 148.6 135.1 133.4 122.2 94 98.1 94.6 127.5 80.5 61.7 94.6 67 50.2 85.8 450.6 394.8 359.6 238.5 373.1 428.9 275.5 283.8 277.3 CE(16:1) 2.6 3.9 4.2 8.2 13.9 8.2 5 8.6 5.7 111.7 118.9 115.1 203.8 158.8 258.2 213.2 194.1 140.8 54.7 43.3 52.7 35.3 20.7 42.2 18 16.1 25.8 287.9 285 248.8 256.8 376.2 359.1 263.9 273 245.7 CE(16:2) 0.2 0.4 0.8 1.1 1.8 1 0.6 1.2 0.6 24.4 29.9 48.2 66.7 48.7 75.2 72.4 65 45.3 12.3 8.8 8 6 3.7 8.9 3.2 2.3 3.5 80.4 69.5 75.8 84.9 109.4 108.9 81.2 75.5 65.8 CE(18:0) 7.8 6.1 5.5 9.6 11.3 18.3 7.7 14.6 8 70.5 78.5 103 64 107 73 92.5 68 61.5 55.5 61.5 70 43.3 25.8 45.2 31.1 25 22 180.9 163.9 158.4 191.4 136 119 89 108.5 94.5 CE(18:1) 31.3 41.4 43.3 123.7 98.2 190.1 61.6 104.1 60 998.2 1730.9 1284.9 439.6 945.1 1640.6 1497.3 1412.3 934.5 876.1 684.9 780.5 546.9 309.5 605.3 257 214 350.4 2670.7 2352.1 2038.9 1927.4 2500.8 1938 1348.6 1470.7 1587.6 CE(18:2) 4.6 7.8 8.5 31.5 15.1 33.6 5.3 10.2 17 142.7 131.4 171 171 229.9 256 228.8 197.1 151.8 258.2 166.5 219.7 139.3 60.7 139.3 51.3 44.1 66.4 318.3 291.1 267.3 306.9 364.7 371.5 241.2 228.8 240.1 CE(20:0) 0.3 1.2 0.8 1.5 2 2.6 1.2 1.6 2.2 10.9 16.9 11.9 12 9.2 26.3 12.7 12.4 8.1 6 6.2 7.5 5.6 3.8 4.6 2.2 2.2 2.6 11.2 11.2 7.7 11.8 10.1 14.9 6.9 5.7 4.5 CE(20:1) 0.9 0.6 1 1.6 2.7 2.4 1 2.6 1.2 14.1 17.4 32.7 8.2 20.5 11.5 15.8 15 15.7 14.2 12.8 12.3 5.2 4.4 9.6 2.9 3.1 5.9 17.7 29.9 22.4 21.1 25.6 35.5 17.5 21.4 22.2 CE(20:2) 4.2 1 1.6 3.3 4.6 2.6 2 3.5 2 26.7 24.4 19.8 18.7 22.2 23.8 24.6 22.8 18.7 27.5 22.4 26.6 14.9 9.2 21 8 9.2 13.5 47.4 41.8 30.8 47.9 50.6 40 30.8 31.6 28.8 CE(20:4) 0.3 8.1 8.2 21.2 25.1 36.8 11.2 16.9 9.3 62.9 220.4 268.3 191.2 188.6 125.4 491.4 227.1 440.9 491.4 227.1 440.9 227.1 61.5 191.2 48.2 31.7 50.6 241.7 241.7 207.2 203.2 256.3 240.4 201.9 200.5 191.2 CE(22:1) 0.6 0.3 0.4 0.5 1.6 1 0.4 1.3 0.5 7.8 10.9 17.5 5.6 13.5 9.1 10 14.6 8.5 8 4.4 10.5 4.5 1.7 4.9 1.9 1.7 2.2 17 16.9 13.9 13.5 17.4 15.3 11.8 15 16.9 CE(22:6) 0.1 4.9 4.1 11.4 7.6 15.1 6.7 9.5 3.8 65.5 70.5 284.2 61 224.4 243 223.1 265.6 155.4 176.6 82.5 148.7 101.5 30 78.6 19.8 17.5 24.3 349.3 298.8 276.2 351.9 314.7 334.7 247 269.6 264.3 Cer(d18:0/16:0) 153.1 243.2 191.5 264.7 273.3 231.4 210.6 188.2 293.7 97.4 456.1 333.1 352 541.3 538.5 297.3 241.1 434.1 257 346.2 248.1 237.7 236.1 246.9 282.7 273.2 301.6 456 469.1 378.5 513.8 390.9 679.3 571.3 389 602.7 Cer(d18:0/18:0) 22.2 11.6 14.7 19.9 26 11.9 14 17.6 14.6 8.6 9.2 26.3 14.6 23.3 25.7 13.8 18.4 21.1 22.6 30.2 24.1 16.7 18.3 17.2 20.7 22.6 18.2 25.8 34.1 35.1 25.1 70.2 45.4 23.7 18.8 29.1 Cer(d18:0/20:0) 5.2 5.2 9.2 10 2.9 3.5 3 6.5 5.9 6.8 1.5 1.5 3.6 16.2 14.5 4.5 3.3 5.9 7.3 14.1 9.3 7.1 10.8 10.2 8.1 11.5 12.4 12 14.6 15.9 10.7 12.8 17.8 14.7 8.4 13.3 Cer(d18:0/22:0) 16.1 9.4 11.4 20.5 10.6 22.8 18 15.4 14.9 21.5 5.9 14.3 14.6 33.4 29.5 17.1 10.5 33.3 19 32.4 24.7 16.7 23.9 22.6 24.3 20 21.4 72 38.9 43.4 37.9 34 62.1 42 29.8 35.6 Cer(d18:0/24:0) 15.3 10 9.8 23.8 23.7 13 6.9 19.7 19.5 9.5 52.5 41.2 23.3 41.7 35.8 30 10.8 30.6 28.6 13.8 14 23.7 13.8 25.7 32 27.8 29.3 44 40.7 38.8 39.6 81.6 61 42.3 51.6 39 Cer(d18:0/24:1) 54.8 31.6 74 91.9 63.5 57.1 52.7 72.3 73.3 45.2 90.8 107.6 114.4 185.7 177.7 82.7 68.3 145.9 91.4 73.7 42.9 88.9 84.8 93.7 81.9 85.1 70.4 130.4 162.5 168.1 155.3 108 210.3 204.7 189.3 131.4 Cer(d18:0/26:0) 0.5 0.1 0.7 1.8 0.1 0.3 2.7 1.4 1.4 0.4 2.6 0.1 3.9 1.7 0.2 0.1 0.1 1.5 1.6 0.8 1.3 0.3 1.5 2.7 1.7 3.1 4.9 5.4 1.4 4.8 0.5 Cer(d18:0/26:1) 2.6 2.6 2.4 4.8 5.5 0.3 3.7 1.1 1.4 0.9 2.6 7.2 3.8 8.8 2.2 3.1 2.9 1.8 4.1 3.3 6.1 3.2 6 0.9 4.9 4.6 2.2 6.9 2.4 1.7 19.2 2.8 4.3 4.1 1.7 Cer(d18:1/16:0) 343.3 334.9 345.3 421.8 386.2 402 419.3 446.7 462.6 134.3 448.4 391.8 490.4 465 462.3 531.7 454.7 493.9 383.7 365.5 363 412.9 389 378.3 430.3 467.6 489.4 406.7 494.9 426.2 566.8 496.9 672.9 644.1 662.2 659.1 Cer(d18:1/18:0) 16.8 15.7 16.5 16 14.1 16 13.8 12.3 13.8 3.2 12.2 8.7 16.2 10.7 14.4 12.1 13.8 11.5 13.5 14.5 16.7 14.9 15.4 15 15.8 16.5 16.6 17.5 11.2 14.4 17.8 46.3 19.4 16.8 15.1 17.3 Cer(d18:1/20:0) 5.8 6.7 6.1 4.4 4.8 6.5 7.5 6.3 5.5 1.7 5.3 3.4 8.9 7.1 7.2 6.6 5.8 6.3 7.7 5.9 6.3 6.2 5.6 6.1 6.6 6.8 7.2 8.1 10.7 7.4 7.9 11 9.5 9.9 8.4 8.2 Cer(d18:1/22:0) 36 33.6 33 34.9 36.8 37.3 40.8 44.3 40.9 51 13.3 40.8 50.1 42.8 50.9 40.1 47.5 39.2 39.4 39.4 42.2 45.7 41.4 39.6 45.7 43.3 42.9 45.3 54.9 66.1 58.7 61.4 69.4 59.1 65.3 72.1 Cer(d18:1/24:0) 92.1 87.8 103.9 102.4 110.9 113.8 117.5 113.8 133 41.2 130.6 133.8 121.6 122.9 131 108.2 108.7 110.5 126.5 106.3 112.7 111.6 122.9 119.6 130.1 139.4 130 156.2 168.4 209.4 200.4 183.7 221.5 185.9 193.2 181.1 Cer(d18:1/24:1) 540.1 516.8 565.2 542.9 625.7 599.1 618 583 694.2 317.7 669.8 618.6 669.4 620.4 644.7 677.7 611.6 590.5 454.2 566.3 577.5 570.8 580.6 532.1 662.9 602.7 609.6 587.4 533.3 637.8 705.4 694.1 786.7 680.2 693.7 727.3 Cer(d18:1/26:0) 2.9 2.8 2.9 2 2.2 3 3.3 3.3 3 3.1 5.5 4.4 3.1 3.2 2.3 1.8 2.3 3.1 1.9 3.1 2.9 2.6 3.1 3.3 2.5 2 2.7 2.5 2.4 4 3.1 12.4 3.6 3.9 3.6 2.6 Cer(d18:1/26:1) 6.7 5 6.5 5.8 9 4.6 8.5 6.4 6.2 24.2 5.7 10.2 9.7 9.3 8.2 8.5 8.8 5.6 5.2 7.3 6.5 5.6 7 10.3 8 6.5 6.9 9.5 7.7 15.9 10.9 67.6 9.4 6.5 14.4 8.7 Cerotic acid 0.4 0.4 0.4 0.7 0.6 0.5 0.6 0.7 0.8 0.6 0.6 0.6 0.6 0.8 0.7 0.5 0.6 0.6 1.1 0.8 0.7 0.6 0.6 0.7 1 0.8 0.7 0.9 1 1.1 1.4 1.3 1.9 0.8 0.8 0.8 Cholestenone 0.4 0.4 0.8 1 1.5 0.7 1 1.1 2.5 Cholesterol 8608.2 9353.6 8621.9 10862.8 15333.6 10251 10186.4 10508.7 12393.4 10169.3 9653.7 9843.2 9796.5 9379.7 12614.8 12065.5 12439 12022.1 14196.9 13443.8 13696.6 13579.4 12170.8 13215.7 13824.5 13884.3 13937.6 29649.1 27369.1 41150.6 42326.3 33207.4 32160.7 29794.4 29279.4 46907.7 cis-Erucic acid 33.1 31.9 39.2 39.9 58.5 55.1 55 48.2 49.1 54.2 53.6 55.9 77 87.7 86.1 79.6 75.2 77.3 71.4 77.5 77.6 69 70.8 74.1 72.1 77.7 66.9 97.7 99.2 120.7 112.2 137.9 111.7 79.5 91.4 75.9 CL(68:4) 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 CL(68:5) 0.1 0.2 0.2 0.2 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.4 0.3 0.4 0.3 0.3 0.3 CL(70:4) 0.1 0.2 0.1 0.2 0.2 0.2 0.3 0.2 0.2 0.2 0.3 0.3 0.3 0.4 0.4 0.3 0.3 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.3 0.3 0.3 0.2 0.3 0.2 CL(70:5) 0.1 0.1 0.1 0.2 0.2 0.2 0.2 0.1 0.2 0.5 0.5 0.5 0.8 1 0.9 0.6 0.6 0.6 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.5 0.5 0.5 0.6 0.7 0.7 0.6 0.5 0.6 CL(70:6) 0.4 0.4 0.4 0.6 0.6 0.6 0.6 0.6 0.6 0.8 0.7 0.7 0.9 0.9 0.9 0.7 0.7 0.7 0.5 0.5 0.5 0.4 0.5 0.5 0.6 0.4 0.4 0.9 0.9 0.8 1 1 1.1 0.9 0.7 0.8 CL(72:4) 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 CL(72:5) 0.4 0.4 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.4 0.4 0.4 0.7 0.8 0.8 0.5 0.5 0.4 0.5 0.6 0.5 0.5 0.5 0.4 0.7 0.5 0.5 0.1 0.3 0.3 0.3 0.5 0.4 0.3 0.5 0.4 CL(72:6) 0.7 0.6 0.7 0.9 1.1 0.9 1.1 1.1 1.1 1.2 0.9 0.8 1.3 1.3 1.3 1 0.9 0.9 0.9 0.8 0.9 0.9 0.8 0.8 0.7 0.9 1 0.9 1.2 0.9 1.4 1.5 1.3 0.9 0.9 1.1 CL(72:7) 1.3 1.5 1.4 1.8 2.1 1.8 1.6 1.7 1.5 0.8 0.7 0.7 1 0.9 0.8 0.6 0.6 0.7 1.4 1.3 1.4 1.3 1.4 1.5 2 1.3 1.3 0.8 0.9 0.9 1 1 1 0.7 0.6 0.7 CL(72:8) 1.9 1.8 1.7 2.3 2.1 2 1.8 2 1.9 0.4 0.4 0.4 0.4 0.5 0.4 0.3 0.3 0.3 1.6 1.5 1.5 1.3 1.4 1.4 2.2 1.5 1.6 0.5 0.5 0.4 0.5 0.5 0.6 0.4 0.4 0.4 CL(74:6) 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.1 0.1 CL(74:7) 0.3 0.3 0.3 0.3 0.4 0.4 0.2 0.3 0.3 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.1 0.1 0.3 0.3 0.4 0.3 0.3 0.3 0.5 0.4 0.6 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 CL(74:8) 0.5 0.5 0.5 0.8 0.6 0.6 0.6 0.7 0.5 0.3 0.2 0.3 0.4 0.4 0.4 0.2 0.3 0.3 0.6 0.4 0.5 0.4 0.5 0.4 0.6 0.5 0.4 0.3 0.3 0.3 0.4 0.4 0.4 0.2 0.3 0.3 CL(74:9) 0.6 0.5 0.6 0.7 0.7 0.7 0.7 0.7 0.6 0.2 0.2 0.3 0.3 0.3 0.3 0.2 0.2 0.2 0.5 0.5 0.6 0.5 0.5 0.5 0.6 0.8 0.6 0.3 0.3 0.3 0.3 0.3 0.4 0.2 0.2 0.3 Coenzyme Q9 30 24 21.2 42.7 38.3 46.9 44.3 44.2 42.3 26.5 24.1 28.1 32.9 35.3 32.6 28 29.6 34.4 43.1 49.6 44.3 46.2 42.1 43.6 40.5 40.8 42.5 11.5 12.5 8.9 24.4 21 25.4 14.4 18.8 14.6 Desmosterol 109.278 66.725 71.997 78.319 54.065 95.618 94.509 64.233 76.17 77.267 71.551 97.07 47.622 54.883 213.208 506.181 338.763 362.582 321.516 DHA 118.4 112.7 125.2 121.9 164.7 159.8 157.5 138.8 159.8 216 221.9 221.3 330.9 333.7 398 307.8 300.3 298.3 243.1 227 255.5 242.8 255.8 270.1 250.4 263 259.8 464.9 457.7 458.9 562.1 556.2 524.3 484.7 534.8 463.9 Dolichol-18 1.6156 1.6156 1.8464 2.0772 2.308 2.0772 2.0772 2.0772 2.0772 2.5388 2.308 2.7696 4.1544 4.1544 3.6928 3.2312 3.0004 3.0004 2.308 2.308 2.5388 2.308 2.0772 2.5388 2.5388 2.308 2.308 2.5388 2.7696 2.7696 3.9236 4.1544 4.1544 3.462 3.462 3.6928 Dolichol-19 1.387 1.387 1.6644 1.6644 1.9418 1.9418 1.9418 1.9418 1.9418 1.9418 1.9418 2.2192 3.3288 3.3288 3.0514 2.774 2.4966 2.4966 2.2192 2.2192 1.9418 1.9418 1.9418 1.9418 1.9418 1.9418 2.2192 1.9418 1.9418 1.9418 2.774 3.0514 2.774 2.4966 2.4966 2.4966 Dolichol-20 0.3036 0.1518 0.3036 0.3036 0.3036 0.3036 0.3036 0.3036 0.3036 0.3036 0.3036 0.3036 0.4554 0.4554 0.4554 0.4554 0.4554 0.4554 0.4554 0.3036 0.3036 0.3036 0.4554 0.3036 0.4554 0.3036 0.3036 0.3036 0.3036 0.3036 0.4554 0.3036 0.3036 0.4554 0.4554 0.3036 EPA 8.7 7.8 9.1 11.1 15.4 12.8 14.7 10.1 12 51.3 62.7 57.9 114.5 94.4 116.8 76 97 84 32.4 27.1 35 27.6 26.6 25.5 20.4 20.4 20.6 191.6 184.2 193.8 281.4 288.7 260.1 267.3 286.4 252.5 gamma-Linolenic acid 17.3 15.4 16.8 25.7 33.4 29.7 27.4 23.2 27 29.3 30.9 29.4 60 54 51.4 36.3 40.4 37 42.5 41.1 42.7 38.7 38.7 40.4 36.4 36.8 35.5 60 58.3 58.9 71.4 74.4 78.6 92.9 97.7 86.8 GlcCer(d18:0/16:0) 48.9 100.2 67.1 91.1 146.7 108.3 51.8 19.4 83.5 35.2 39.8 57.9 118.4 59 84.6 116.1 42.6 157.1 54.1 41.9 107.9 86.1 87.9 33.5 135.8 51.4 21.1 87.1 53 140.6 92.4 69.8 58.7 169.1 103.3 GlcCer(d18:0/18:0) 16.3 8.6 2.3 7.3 0.3 33.4 0.7 1.2 9.7 0.5 7.1 20.2 13.1 0.4 3.8 3.8 GlcCer(d18:0/20:0) 7 1.2 6.2 2.7 0.8 3.4 3.2 22.3 14.9 13.8 4.1 3.6 0.2 4.1 3.2 0.3 2.7 8.5 0.2 4.1 1 11.4 0.9 4.6 GlcCer(d18:0/22:0) 7.8 27.3 17.5 16.2 10.6 12.7 20.5 0.2 10.9 23.8 11.5 8 32.1 2.1 12.2 12.7 16.6 14.4 6 60.5 14.9 5.6 3.3 43 5.5 14.9 GlcCer(d18:0/24:0) 5.6 41 12.9 36.4 6.9 33.9 6.5 17.9 7.4 47 2.7 7.2 8.9 2 4.3 11.1 8.6 144.3 16.7 10.1 6.1 32.3 26.2 GlcCer(d18:0/24:1) 31.8 29.9 23 66.9 56.3 59.6 56.7 46.7 12 37.6 47.1 22 23.3 36.1 21.6 35.6 41.4 35.8 52.8 5.8 11 37.7 56.7 22.4 50.5 18.1 19 23.8 27.1 37.5 30.7 64.4 GlcCer(d18:0/26:0) 5.9 1.3 7.1 36.4 2.7 2.7 2.3 3 2.5 53.3 5.7 4.8 1 GlcCer(d18:0/26:1) 2.5 1.4 1.6 8.2 4.6 5 1.6 2.1 2.7 3.6 1.3 1.7 1.5 GlcCer(d18:1/16:0) 608.3 710.5 754.8 838.6 916.7 771.9 819.1 656.3 840.8 225.1 866.3 840.7 1142.9 941.2 1094.5 688.9 687.5 845.9 838.6 891.3 904.3 854.5 865.3 871.5 768.2 657.7 722.5 714.7 583.3 545.3 844 897.6 932.5 688.2 716.3 702.6 GlcCer(d18:1/18:0) 21.9 16.8 13.9 20.9 18.4 19.5 14.7 20.7 26.6 4.6 29.7 28.2 38.5 29.5 31.1 25 24.2 16.5 14.6 18.2 23 20.7 18.3 19.7 23.4 22.7 24.1 23.6 16.3 17.1 17.3 18.6 24.6 10.2 16.6 13.9 GlcCer(d18:1/20:0) 10.8 7 13.6 8.1 13.2 10.9 14 9.1 11.2 5.2 16.9 13.4 13.7 14.3 18.1 10.4 16.2 8.6 13.3 10.1 10.8 24.7 18.2 11.7 10.8 14.3 13 8.7 14.8 13 12.8 9.6 9.4 11.2 10.6 8.4 GlcCer(d18:1/22:0) 97.9 111.5 111.9 120.6 126.9 157.4 112.3 142.7 124.1 58.8 186.3 190.3 179.8 143.1 134.8 134.6 118.3 107.2 110.8 129 121.3 190 125.4 115.4 146 126.5 170.3 222.6 104.5 146.2 114.4 143.4 131 118.6 145.2 126.3 GlcCer(d18:1/24:0) 237.8 207.9 231.3 250 260.6 330.1 267.6 234.7 264.2 395.3 110.9 381.2 301.7 233.7 218.2 214.7 240 211.6 284.3 246.9 213.6 428.2 271.9 254.2 285 459.3 297.7 441.5 328.8 231.4 277.2 270.5 257.5 237.2 292.1 221.3 GlcCer(d18:1/24:1) 591.7 696.8 598.7 724.7 737.5 881.4 701.7 740.2 733.7 784.7 829.2 259.6 813.7 970.6 798.5 736.3 579.2 683.3 639.2 750 769.6 872.7 718.6 731.8 781.5 700 848.6 560.9 658.5 587 664 620.5 672.5 521.1 606.7 548.8 GlcCer(d18:1/26:0) 5.6 5.6 5.7 2.5 5 3.3 3.8 1.7 1.9 2.3 2.1 8.2 2.9 2.5 2 2.8 1.4 3 3 2 5.1 4.4 2.4 2.5 4 2.2 4.5 8 1.7 1.7 2.8 3.1 2.2 1.6 1.2 GlcCer(d18:1/26:1) 8.8 8.1 4 5.7 5.4 7.3 8.9 6 3.4 5.1 10.4 2.2 5.5 9.9 4.3 2.3 5.7 6 4.7 7.6 6.5 5.1 8.1 3.2 5.1 8.9 6.3 6.4 6.9 3.3 6 3.3 5.7 2.1 3.9 3.3 Lanosterol 2.5 2.3 2.6 3.5 2.8 6.8 2.6 3.2 4.6 3.7 3.2 2.9 3.4 3.9 4 4.9 4.3 4.7 2.6 2.4 2.5 2.8 2.7 2.9 2.9 3.5 2.4 5.3 4.7 9.4 10.3 10.6 9 8.6 Lauric acid 6.3 16.5 2.5 5.8 23 3.8 8.1 1.8 22.6 12.3 10.2 17.7 23.5 23.7 23.2 22.9 18.7 18.2 5.4 5.2 4.2 19.4 2.8 5 4.7 6.1 3.9 19.3 17.7 24 31.4 30.8 31.2 58.5 45 38.6 Lignoceric acid 2.9 2.8 3.1 3.6 3.9 3.9 4.3 4.2 4.7 4.1 4.2 4.4 5.1 5.7 5.9 4.8 5 5.3 6.7 6.1 6.2 5.3 6 6.3 7.3 6.7 6.5 8.4 8.5 8.7 11.2 11.7 12 7.2 7.6 7.1 Linoleic acid 550.7 502 533.6 713.5 867.2 861.3 720.5 696.1 764.7 306.5 344.8 337 635.6 552.2 555.8 432.5 462.5 433.2 1080.4 1134.1 1065.5 1057.7 1092.1 997.4 1034.5 1042.1 1009.2 686.2 666.4 668.8 784.6 741.4 803.6 839.1 865.1 775.2 LTE4 7.6 5.6 4.3 3.4 5.4 6.2 7.9 3.6 3.8 4.9 3.7 7.5 5.9 6.7 4.4 6 5 6.8 6.4 3.5 3.5 5.1 3.6 6.5 3.6 5 4.4 6.7 7 7.6 3.7 7.6 6.8 6.9 7.2 8.2 Margaric acid 26 35.9 40.1 36.5 48.2 43.8 44.9 43 42.6 67.9 65 70.5 99.4 103.8 108 78.7 79.6 81.4 58.7 73.7 48.7 54.1 49.6 73.5 52.6 48 49 119.5 116.1 123.6 139 145.2 139.2 123.9 124.9 114.9 Myristic acid 61.9 85.1 89.9 89.1 110.4 97.6 105.9 102.7 99.6 213.6 212.2 217.7 326.5 338.8 367.7 260.4 264 263.6 129.8 136.5 109.5 128.3 116.4 142.8 128.6 114.9 118.9 384.8 374 384 441.1 429.9 430 440.6 477.2 408.6 Nervonic acid 2.2 2.3 2.8 2.4 3.3 3.5 3.7 3.4 3.3 3.1 3.1 3.5 4.2 4.8 4.6 4.5 4.3 4.3 5 4.7 5.4 4.4 4.9 5.1 5.1 5.9 4.6 7.2 7.2 8.4 8.6 10.6 8.5 5.9 6.8 5.7 Oleic acid 940.2 860.6 845.4 966.9 1034.2 1055.3 924.8 981.7 982.1 1207.6 1161 1137.8 1346.7 1289.7 1348.5 1274.3 1169.1 1164 1097.4 1144.8 1084.7 1074.9 1127.4 1138.1 1102.4 1081.8 1079.5 1318.1 1344.8 1301.6 1274.4 1264.3 1269 1291.1 1332.1 1269.6 PA(32:0) 10.9 11.2 11.2 12.9 13 12.2 10 7.4 4.7 4.1 5.6 4.5 8.3 7.7 7.1 6.3 10.9 9.2 8.7 6.2 8.4 9.1 9.2 8.1 6.2 6.2 6.6 5.5 8.4 7.8 9.4 9.1 PA(32:1) 1.8 3.3 1.4 1.5 1.9 1.7 1.4 2.3 2.9 3.2 3.9 3.6 6.6 5.1 4.6 5.7 2.2 1.7 2.6 1.4 1.9 2.8 1.7 2.2 5.2 5.1 5.1 4.6 7.7 6 6.7 7.6 PA(34:0) 9.3 15.8 9.8 11 7.2 8.9 9.5 8.6 4.7 4.2 3.8 4.2 5.5 5.1 4.9 6 7.6 6.8 7.8 6.4 6.1 6.8 8.6 7.2 7.4 6.4 7.6 7.7 8.3 8.1 7.6 8.3 PA(34:1) 20.9 27.6 20.4 24.7 21.5 22.2 18 21.5 20.8 18.1 20.9 18.3 22.5 19.2 27.1 23.5 21.5 9.3 15.2 17.5 17 13.7 16.8 16.2 15.3 17.4 19 16.9 26.4 24.1 19.9 19.9 PA(34:2) 7.4 6 5 7 4.7 5.5 4.7 5.6 4.7 5 5.1 4.3 6.6 5.4 4.4 5.1 5.6 5.2 2.6 4 3.6 4.6 4.5 4.6 4.2 4 4.2 4.9 7.1 4.9 5.5 6.2 PA(36:0) 4.9 6.5 3.4 4.9 4.1 3.8 4 3.5 4.6 4.3 4.7 4.4 6.1 6.3 5 7.1 4.1 4.5 3.8 1.8 3.7 4.5 3.9 4.6 3.3 3.8 3.2 3.2 3.6 4.3 4.1 4.1 PA(36:1) 35.5 21.7 29.1 26.1 22.4 23.4 19.3 20.6 22.1 17.6 21 19.9 17.5 16.6 25 22 20.3 22.4 12.4 26.1 17.8 20.8 19.8 21.3 17.5 20.5 20.4 18.3 20.4 24.5 21.1 26.6 PA(36:2) 34.2 41.8 41.6 32.8 33.9 33.8 27.9 33.3 25.6 23.7 25.2 21.9 24.4 21 30.7 24.8 12.6 26.1 34.4 29.5 28.8 21.8 24.1 27.4 16.6 18.8 16.1 18.2 25.9 21.2 24 20.7 PA(36:3) 5.8 8.9 6.9 6.3 7.2 5.9 8 6.7 3 6.3 4.2 7.3 9.7 8.3 6.3 7.7 4.5 5.8 1.7 7.2 3.6 4.7 5.7 4.9 4.6 4.9 5.4 5.4 7.7 6.2 6.3 8.3 PA(36:4) 4.6 3.7 5.9 3.9 4 5.1 5.7 3.6 3 3.7 3.1 2.8 4.9 2.6 5.7 3.9 3.7 1.7 5.1 6.4 5.1 3.3 5.5 4.8 2.5 2.3 3.2 2.8 3.6 4.8 3.7 4.6 PA(38:2) 3.4 2.7 2.8 2.4 2.9 2.3 2.1 2.6 2.4 2.6 2.8 2.7 2.8 3.3 3.7 3.3 2.4 1.1 2.5 1.1 2.7 2.6 2.3 2.5 1.6 1.9 1.8 1.7 2 1.9 2.2 2.6 PA(38:3) 8.7 8.7 9.3 12.5 7.7 6.7 8.7 5.8 6.9 9 7 8.9 10.4 9.8 8 11.2 10.1 7.6 3.7 8.5 8.1 10 7.5 8.9 6.7 8.4 8.1 8.1 8.6 9.9 9 10.6 PA(38:4) 28 27.7 18.3 19.8 19.3 18 23.6 17.4 11.3 12.2 13.2 13 16.4 16.7 15.7 17.8 20.7 29.1 24.4 11.2 23.1 18.3 22.4 24.9 14.3 15.2 14.5 14 18 17.3 13.3 19.5 PA(40:3) 5.5 3.5 7.7 6.7 3.3 2.9 4.8 4.8 1.6 0.8 2.7 1 4.2 3.9 3.2 2.1 3.8 4.4 4.1 2.9 5.2 4 5.7 6 2.4 1.7 2.6 2.6 2.3 2.8 2.7 2.6 PA(40:4) 27 22.7 27.8 23.9 18.8 19.8 14.6 20 3.8 6.7 6.1 3.2 9.1 9.8 9.7 9.6 21.8 34.3 27.5 14.5 31.7 17.8 24.5 23.8 6.3 7.7 5.7 5.7 6.5 8.7 9.5 7.7 PA(40:5) 10.5 17.4 21.6 12 8.7 13.8 12.8 10.8 8.3 15.3 14.2 15.3 14.5 22.3 21.7 13 14.4 18.9 16.2 9.5 13.8 13.3 18.1 17.3 11.3 16.9 15.4 11.7 19.7 17.3 14.7 15.9 PA(40:6) 12.3 13.1 18 13.3 11 7.2 8.6 8.6 9 11 9.3 10.2 13.1 11.9 19.5 21 8.4 13.9 12.6 6.6 11 8.3 12.4 13.8 14 14.5 14.5 16.6 19.9 16.7 16.5 17.1 Palmitic acid 811 929.3 891.8 1016.8 1174.7 1209.9 912.9 1138.6 1063.3 1799.6 1483 1388.8 2207.8 2422 2584.1 1846.2 1576.3 1516.3 1356.9 1592.5 1233.1 1441.9 1228.4 1548 1342.4 1246.2 1264.3 2476.4 2457.9 2292.6 2254.8 2141.4 2269.7 2450.8 2753.6 2359.8 Palmitoleic acid 68.4 62.1 72.8 102.5 142.6 129.2 138.5 100.7 116.9 360 393.2 386.4 652.1 668.9 708.1 487.7 541.3 509.9 215.7 204.7 226.8 191.7 204.4 207.6 156.1 164.8 154.6 734.9 728.1 778.4 833.8 871.3 836.5 949.9 1045.3 881.5 PC(32:0) 57 55.4 57.4 44 51.8 43.1 50.7 45.1 39.4 40.5 38.8 35.6 43.2 45.1 40.3 42.5 46.4 55.2 38.1 50 73.2 54.2 46.9 55.9 43.7 42.3 43.1 40.7 49.6 61.7 47.2 49.6 PC(32:1) 21.2 25 27.7 29.6 25.7 25 22.2 23 41.2 43.6 42.6 44.3 46.4 47.9 51.4 45 68.5 29.8 21.3 26.7 26.7 10.4 27.9 29.3 51.9 55.9 51.7 51.2 73.4 60 55.7 55.5 PC(32:2) 3.2 3.8 3.3 3.7 3 3.7 3.2 2.9 7 6.8 6.1 6.4 8.3 7.3 7.2 6.8 3.5 2.6 3.5 3.8 3.5 3.6 2.3 4 7.9 9.1 7.8 8 8.9 10 8.9 8.2 PC(34:0) 19.7 30.4 27.7 28.2 21.6 23.8 24.4 22.2 25.3 28.2 23.6 24.7 29.6 31.1 29.1 27.3 22.9 18.1 20.8 21.5 39 24.8 26.4 24.6 22.2 29.9 29.4 24.2 27.2 31.9 27.7 29.4 PC(34:1) 49.5 62.5 63.5 40.3 44.5 48.9 44.2 40.9 49.3 43.8 43.8 46.4 44.3 50.4 52.8 51.8 37.5 48.7 58.2 46.4 42.1 66.9 54.3 49.4 58.9 57.6 59.2 51.5 59.2 73.6 68.5 57.5 PC(34:2) 47.7 32.7 44.9 39.2 30.2 31.6 36 37.1 24.1 24.6 25.7 23.6 28 26.2 27.3 25.1 31.7 34.7 42.8 27.8 36.4 38.5 45.1 28.9 31.5 33.8 34.7 35.8 39.3 37 38.4 45.7 PC(34:3) 4.9 4.2 5.3 3.5 3.8 4.5 4.1 3.7 4.3 4 4.2 4.4 4.9 4.3 4.6 4.4 3.9 4.4 3.6 4.4 4.2 6.2 4.6 4.1 5.6 5.5 6.1 5.3 6 7.6 6.5 6.3 PC(36:0) 5.5 10.2 6.6 10.1 7.7 8.1 9.8 9.3 13.3 15.1 14.9 10.3 14.9 14.8 13 14.2 8.9 8.6 5.1 10.1 11.1 8 7.9 14.2 11.2 10.2 13.1 14.2 14.2 15.1 11.9 17.4 PC(36:1) 55.7 43.9 60.1 38.1 46.9 53.3 48.1 47.3 59.4 54.9 57.3 59.8 67.7 64.7 60.5 69.4 45.4 46.9 38.8 97.9 48.1 55.8 74 49.2 67 70.7 59.9 66.8 73.5 76.4 98.8 75.3 PC(36:2) 102.2 124 130.8 79.5 80.7 92.2 92.9 87.1 92.8 73.6 92.7 94.1 97.1 104.3 99.9 79.9 92.8 88.4 67.7 12.7 84.7 94.5 93.4 132.2 36 40.1 36.8 37.2 31.7 31.5 28.6 27 PC(36:3) 52.4 97.7 83.3 67.1 52.9 53.1 57.2 60.9 43.6 40.5 38.6 39.8 47.4 46.4 46.8 40.6 58.1 64.1 48.9 61.5 62.9 60.5 87 52.7 51.7 51.7 56.1 56.6 72.1 56 64.2 58.8 PC(36:4) 69.6 57.9 42.6 70.4 44.7 49.1 40.6 43.9 26 28 31.6 28.9 32 33 35.6 36.6 47.9 54.7 62.4 58.3 44.7 75.6 62 55.5 53.5 47.9 47.9 47.9 59.6 50.7 63.2 57.1 PC(38:2) 23.9 12.2 13.2 14.8 12.2 15 14.7 12.9 15.1 13.8 13.7 13.5 16 16.3 16.9 18.2 9.8 8.9 7.7 13 13.7 18.1 11.9 11.2 13.9 15.7 13.7 12.8 14.7 15.2 18.3 15.9 PC(38:3) 29 54.8 41.6 37.4 38.2 32.5 34.9 35 25.1 26 24.7 27.7 32.5 30.8 34.3 31.9 39.88 37.1 26.49 22.16 30.94 38.14 58.91 31.99 25.54 35.43 34.05 32.87 32.26 31.74 40.43 35 PC(38:4) 91.89 120.91 74.52 61.26 82.34 78.9 70.18 68.1 45.34 44.85 48.51 40.61 50.97 56.97 58.35 52.19 82.41 69.2 57.85 90.56 78.79 76.06 15.97 82.2 70.63 58.31 67.09 66.64 72.33 86.9 68.51 69.68 PC(38:5) 40.64 73.84 53.47 49.15 48.47 48.57 43.78 47.4 60.77 51.63 53.15 47.97 56.36 65.83 64.2 64.91 54.91 53.87 43.95 41.15 55.82 53.13 74.92 48.53 67.36 56.96 67.05 73.82 86.13 71.19 68.83 67.81 PC(38:6) 65.88 60.53 55.59 49 58.47 52.71 60.12 52.71 63.82 67.53 63 63 63.82 62.18 63.41 63 65.06 55.59 69.18 64.65 56.42 61.35 84.82 66.3 73.71 83.59 90.18 79.47 93.88 112.41 86.06 84.41 PC(40:3) 14.53 14.34 14.45 25.37 15.28 17.57 16.82 13.38 8.73 8.66 10.42 10.51 13.33 12.97 10.97 12.33 9.71 9.08 7.65 15.21 12 15.32 16.99 15.89 9.53 8.73 9.23 8.96 9.47 12.02 11.22 9.72 PC(40:4) 40.92 35.72 40.86 69.35 43.93 37.14 42.39 35.7 17.25 18.5 17.81 15.03 20.69 27.47 21.06 24.25 25.9 32.1 27.21 35.37 32.38 46.7 36.26 39.3 18.61 18.12 15.49 15.88 18.05 19.39 19.56 18.65 PC(40:5) 39.5 45.9 36.4 80.79 35.12 41.78 41.56 33.51 29.29 35.31 31.57 29.25 36.88 35.39 37.63 34.12 25.19 29.54 35.2 30.19 34.14 31.33 47.33 36.56 23.89 31.16 30.94 32.75 32.23 35.32 34.33 38.17 PC(40:6) 36.51 42.86 65.31 46.23 40.69 38.91 40 35.14 70.8 55.2 58.17 60.57 64.05 65.66 67.6 30.23 44.12 35.03 31.48 40.23 43.43 40.29 45.66 59.66 54.97 71.66 62.85 66.97 69.15 76.46 64.29 59.37 PC(P-36:0)/PC(O-36:1) 5.7 9.3 5.9 6.5 5.8 6.2 6.3 5.4 12.4 9.3 11.2 9.7 10.6 10 11.4 10.5 5.2 3.6 4.7 4.1 5.7 5 7.5 6 8.3 9.8 9.1 8.8 9.9 10.5 9.6 10.5 PC(P-36:1)/PC(O-36:2) 18.8 16.3 16.3 15.5 12.6 15.2 13 15.6 21.1 18.4 19 22.9 21.5 20.4 18.8 20.4 9.3 12.5 12.1 10.1 11.5 19.5 14.7 13.2 17.5 18.6 18.4 19.7 22.6 20.4 26.8 19.3 PC(P-36:2)/PC(O-36:3) 20.2 22.1 22.5 23.7 17.7 18.4 21.7 20.9 18.2 19.4 17.4 17.1 19.1 17.7 17.7 17.9 19.5 16 17.8 12.8 18.7 21.2 32.9 18.3 18.9 19.4 20.7 20.9 22.6 21 22.7 26.3 PC(P-36:3)/PC(O-36:4) 36.4 38.5 32.4 34.7 34.3 28 33.9 28.9 21.5 21.4 23.7 21.1 23.5 23.8 25.1 26 29 38.2 34.9 26.4 41.5 30.5 58.3 32 32.9 32.8 29.8 35.9 38.7 34.9 44.5 33.2 PC(P-36:4)/PC(O-36:5) 4.2 3.5 3.3 2.6 3.3 3.8 3.9 4.1 3.4 3.8 3.9 3.7 4.5 4.8 4.8 4.6 3.7 4 4 2.6 4.2 5.4 3.8 7.1 4.9 5.3 5.3 4.8 8 5.6 6.4 6.4 PC(P-38:1)/PC(O-38:2) 3.2 3.1 3.7 6 3 3.5 3.3 3.2 5.2 4.3 5.3 4.8 4.6 4.3 5 4.6 2.6 1.6 2.7 2.3 3 3.8 3.5 3.2 4.1 3.8 3.5 3.9 4.3 4.1 4.6 4.1 PC(P-38:2)/PC(O-38:3) 24.26 15.84 15.25 13.53 15.21 15.56 15.07 15.06 13.05 14.04 15.61 16.11 16.17 16.25 17.61 16.25 9.32 14.36 11.85 11.23 14.55 14.61 15.77 17.03 12.75 14.79 14.06 13.93 15.98 15.42 15.47 14.18 PC(P-38:4)/PC(O-38:5) 55.86 49.89 52.1 50.74 44.88 52.92 45.02 54.6 43.78 36.05 39.68 33.78 43.72 42.41 47.77 46.33 62.58 51.33 39.52 45.08 62.78 55.57 43.43 51.23 53.68 46.57 50.69 52.91 56.79 55.69 54.99 69.04 PC(P-38:5)/PC(O-38:6) 6.17 7.3 7.04 6.34 6.21 5.97 6.85 5.6 10.2 8.52 9.21 8.25 9.83 9.15 10.71 10.25 5.82 5.95 6.85 4.66 10.69 6.59 6.1 7.7 11.8 12.54 11.49 12.23 17.66 13.05 14.35 12.13 PE(32:0) 6.62 7.64 8.02 10.16 10.81 10.23 10.92 9.2 7.2 7.33 7.05 7.79 8.83 9.1 8.98 7.38 9.29 9.44 7.95 11.08 9.96 8.58 9.18 9.13 7.48 8.66 8.11 8.5 11.72 9.96 11.41 11.24 PE(32:1) 3.65 7.17 4.39 4.56 5.17 5.8 5.51 5.36 12.22 10.45 11.69 12.67 14.32 11.55 13.96 13.39 6.38 4.64 7.11 4.95 6.04 5.25 5.18 5.18 17.28 16.59 18.94 14.39 21.47 18.38 20.44 22.02 PE(32:2) 2.45 1.89 1.46 1.29 1.12 1.54 1.47 1.83 3.09 3 3.03 3.57 4.18 4.3 4.28 3.65 1.3 1.92 1.29 1.15 1.97 1.47 1.97 1.82 3.39 3.59 3.39 3.59 4.72 4.07 5.13 4.87 PE(34:0) 12.79 13.86 14.04 11.82 14.65 16.25 16.07 16.51 15.68 17.28 14.7 15.71 16.9 19.92 18.44 16.01 16.07 15.03 14.18 12.88 15.72 15.97 13.99 16.23 16.25 16.47 16.13 15.77 19.11 16.66 16.25 17.41 PE(34:1) 37.18 41.56 45.95 40.85 49.85 49.86 45.22 48.59 49.49 54.37 52.56 51.64 58.27 52.08 58.52 57.89 42.8 40.32 50.18 47.63 44.8 45.57 42.73 44.71 45.95 52.27 54.59 50.45 65.63 57.58 69.36 68.1 PE(34:2) 22.74 29.24 23.95 21.56 27.64 27.81 25.45 27.52 25.03 23.21 26.53 24.56 26.37 22.45 25.25 26.4 27.62 27.45 23.41 22.23 25 23.28 24.49 21.75 28.32 28.35 29.81 23.88 31.41 36.35 35.07 36.35 PE(36:1) 61.41 54.1 52.16 43.96 44.97 44.43 39.55 40.94 50.08 45.79 52.67 53.09 34.97 36.66 40.45 31.9 51.88 49.84 57.83 48.28 41.06 39.49 43.65 44.67 58.44 53.53 53.26 53.21 47.25 59.84 56.53 59.42 PE(36:2) 73.29 71.26 76.29 66.58 42.08 41.1 39.14 43.8 61.82 54.77 64.31 64.03 46.2 47.19 40.9 48.45 65.52 65.8 88.99 70.81 36.34 38.9 37.57 39.58 72.75 61.14 63.08 62.04 58.36 59.84 60.81 48.21 PE(36:3) 39.98 35 38.16 37.27 70.22 80.08 67.56 75.53 36.6 43.32 39.71 41.24 64.9 59.59 71.36 66.8 33.26 42.02 41.31 35.35 69.08 69.08 66.04 62.62 44.69 42.33 48.42 45.26 80.85 69.08 85.77 83.88 PE(36:4) 47.19 37.99 44.13 43.41 50.91 51.3 58.8 56.83 33.71 33.77 34.07 28.47 59.59 62.35 49.72 54.07 49.6 41.18 50.98 39.97 55.25 52.09 54.86 50.91 42.38 44.91 48.39 51.23 61.17 66.69 73.4 74.19 PE(38:3) 46.49 69.69 78.39 72.05 63.32 54.94 51.08 59.74 40.32 46.22 45.57 44.38 50.28 50.36 42.78 46.18 64.12 61.88 62.12 60.01 53.99 59.85 60.25 62.91 55.14 67.57 56.85 55.57 71.29 64.88 56.45 59.44 PE(38:4) 154.7 181.04 115.87 144.39 107.92 105 147.11 124.61 76.85 66.32 75.01 75.37 87.6 75.01 79.72 90.09 139.57 169.49 142.31 130.75 103.25 127.43 127.5 124.56 102.13 106.3 120.12 118.78 119.32 145.27 127.8 107.08 PE(38:5) 38.99 32.04 30.52 35.41 26.89 33.41 30.25 27.25 44.14 36.17 45.58 45.96 51.43 50 44.18 46.05 32.34 38.2 40.68 30.25 31.56 32.2 30.3 31.08 64.05 61.14 58.32 69.87 69.14 80.45 78.85 64.06 PE(38:6) 19.71 20.53 17.32 16.99 15.72 14.56 18.25 18.69 20.53 16.74 20.58 22.08 18.73 20 21.88 21.49 24.12 18.54 19.36 17.67 18.63 17.76 16.7 37.47 29.65 28.24 29.65 38.58 41.06 33.49 29.46 PE(40:5) 38.41 44.48 38.66 26.88 27.17 28.32 38.85 34.11 21.33 25.1 23.79 25.79 29.23 25.83 28.57 31.33 41.41 38.77 37.41 33.52 33.96 28.38 35 31.88 30.42 31.43 38.15 30.32 34.15 32.27 32.19 38.93 PE(40:6) 24.06 36.78 31.19 33.3 23.78 29.36 19.83 20.77 26.2 20.65 23.59 25.79 30.21 28.6 28.3 22.62 28.26 34.48 31.5 29.85 22.2 26.38 25.5 26.74 34.82 38.95 34.2 44.94 45.14 36.25 37.89 42.36 PE(O-32:0) 4.53 5.88 4.35 10.82 5.42 5.59 4.93 4.49 6.69 6.42 6.39 5.9 5.79 5.49 6.8 4.95 4.35 8.24 3.84 4.38 5.89 4.3 9.74 5.55 9.37 12.15 10.34 10.64 10.35 9.45 9.99 10.04 PE(P-36:0)/PE(O-36:1) 4.5 4.71 5.68 4.15 4.26 3.8 3.99 4.36 8.54 8.12 7.1 8.35 7.77 8.06 7.49 6.79 3.59 4.17 3.61 3.84 3.81 4.08 3.9 3.94 6.9 7.37 6.59 7.17 7.88 7.57 7.99 8.06 PE(P-36:1)/PE(O-36:2) 10.82 9.34 10.84 8.47 7.24 8.6 7.6 8.51 12.25 15.02 13.32 14.44 12.16 13.44 13.21 12.37 6.61 7.15 7.92 7.25 7.76 7.41 6.88 6.78 10.41 10.69 9.59 10.45 13.96 11.91 14.68 12.64 PE(P-36:2)/PE(O-36:3) 13.49 13.98 10.4 11.54 9.81 10 9.66 10.41 16.72 14.85 14.2 17.1 13.55 14.22 15.66 15.72 8 8.87 8.53 8.4 9.16 9.59 9.31 9.47 10.83 11.25 12.03 11.12 13.08 13.37 13.59 13.96 PE(P-36:3)/PE(O-36:4) 24.02 16.69 23.63 23.8 19.63 22.85 19 17.78 24.51 20.33 21.81 18.23 22.08 26.26 19.5 21.67 20.38 20.98 22.06 20.05 23.02 18.4 20.72 21.14 15.7 14.61 16.53 15.76 16.97 18.41 20.17 18.24 PE(P-36:4)/PE(O-36:5) 62.5 71.28 61.24 67.09 63.81 58.18 56.99 64.57 52.99 51.12 49.39 49.5 62.73 61.48 56.54 54.99 60.06 58.18 58.55 67.14 66.63 57.57 62.77 62.22 43.2 46.11 48.19 43.88 48.78 55.18 57.25 52.18 PE(P-38:1)/PE(O-38:2) 6.01 5.15 5.13 5.9 3.9 4.99 4.86 4.68 10.03 6.98 8.09 9.21 7.82 7.35 8.45 8.37 4.31 4.31 4.06 4.94 4.44 4.65 4.29 4.98 7.34 7.02 7.77 7.03 7.62 8.51 8.71 8.01 PE(P-38:2)/PE(O-38:3) 16.53 18.22 13.36 16.4 13.53 15.03 12.78 15.03 15.76 19.85 20.31 18.09 19.38 18.05 20.42 19.05 14.46 13.88 12.69 13.99 15.15 12.78 13.13 14.13 17.51 16.29 15.05 14.54 16.89 17.62 17.97 17.33 PE(P-38:4)/PE(O-38:5) 123.97 116.2 113.31 136.27 118.26 105.79 120.45 105.03 86.6 96.81 86.42 83.61 97.71 101.25 104.46 113.29 101.86 118.56 129.1 119.65 115.07 111.89 119.51 101.85 79.75 73.54 91.88 78.67 87.07 96.81 94.19 87.87 Pentadecylic acid 15.6 20.5 22.1 23.4 27.2 24.1 26.1 23.9 22.8 77.9 80.5 82.8 122.6 126 137.4 94.4 99.8 99.3 32.5 35.3 28.1 29.7 27.9 35.3 33.8 27.9 28.7 139.4 135.3 141.2 179 184.2 179.5 175.5 185.8 168 PG(34:2) 3.64 5.69 4.06 5.97 4.97 5.54 5.44 5.51 7.3 6.36 8.55 7.37 9.74 7.87 8 8.59 1.16 5.33 7.34 4.64 5.01 4.38 4.53 4.38 33.12 30.79 23.49 27.12 23.89 33.29 26.22 29.25 PG(36:1) 12.98 25.64 44.63 104.91 12.85 15.17 7.45 10.16 41.42 30.93 28.86 29.21 32.69 59.47 40.73 34.47 41.02 10.26 12.09 8.28 13.29 12.45 14.1 20.26 86.03 80.99 108.55 108.49 88.42 73.97 100.73 113.65 PG(36:2) 41.52 137.92 48.6 132.55 147 140.32 135.22 135.49 202.39 197.56 167.88 210.06 144.17 183.99 220.03 219.65 101.57 110.53 133.82 44.08 118.44 97.19 108.5 123.26 43.23 314.54 42.81 354.79 352.94 38.79 404.78 40.45 PG(36:3) 118.95 32.31 157.12 102.08 127.44 117.68 115.65 119.99 93.19 78.17 93.6 89.06 100.4 94.11 84.99 81.16 90.27 133.48 124.71 98.31 87.56 85.11 109.66 104.87 134.93 145.57 116.23 127.25 172.24 167.13 146.32 127.59 PG(38:2) 19.63 9.08 20.51 8.77 6.91 12.24 10.2 5.3 6.05 16.66 15.18 14.53 8.73 17.44 16.52 6.84 13.51 5.98 4.83 4.8 9.15 9.84 5.02 3.07 22.77 26.49 28.72 24.07 18.38 21.84 18.1 25.91 PG(38:3) 53.39 18.21 53.15 15.31 18.38 19.39 15.04 16.54 24.77 25.89 25.47 11.71 29.78 36.37 19.78 30.65 15.94 27.98 14.23 13.36 21.48 17.64 17.89 13.88 40.6 47.79 41.79 45.2 54 54.65 63.29 43.12 PG(38:4) 71.78 38.95 109.33 31.34 34.84 45.89 43.66 32.93 57.82 51.65 46.46 48.14 82.05 30.88 63.4 58.8 79.28 34.75 39.52 39.18 53.8 40.32 46.99 41.61 166.89 173.92 83.22 89.09 146.45 118.76 97.68 124.44 PG(38:5) 56.35 48.14 160.76 105.45 74.33 71.39 64.56 44.69 40.19 31.89 35.26 48.06 47.28 75.8 68.02 51.17 144.34 71.91 78.39 77.01 67.94 106.31 62.4 83.41 164.22 176.32 124.46 121.87 153.85 124.46 161.63 131.38 PG(40:4) 4.11 3.12 2.88 2.79 2.08 2.11 1.84 0.01 2.1 0.27 1.66 2.48 4.26 2.35 7.41 7.72 10.08 10.01 8.15 2.92 5.42 PG(40:5) 115.63 116.51 72.54 61.28 61.49 67.24 69.82 63.11 34.39 30.5 33.33 36.63 40.74 48.8 44.92 51.31 62.62 48.86 36.94 51.4 47.59 59.94 62.77 50.37 54.52 58.44 63.73 51.94 40.97 60.95 62.65 58.16 PG(40:6) 196.97 208.07 95.08 111.89 99.36 97 104.53 94.35 92.36 105.12 101.18 110.2 128.89 128.13 104.95 123.72 81.15 102.09 87.12 170.11 103.93 97.29 79.07 77.66 1.21 197.49 209.8 221.01 187.05 211.2 245 223.59 PG(40:7) 112.91 121.34 288.09 236.23 111.6 116.96 106.61 108.18 124.77 144.58 146.07 161.8 162.57 161 134.05 176.92 113.75 111.35 128.47 226.24 93.28 126.35 91.87 122.99 420.1 427.57 465.76 481.85 379.77 490.59 494.58 444.18 PG(40:8) 47.28 125.2 95.54 48.31 47.72 47.5 50.96 46.9 27.12 31.86 31.59 34.38 35.94 30.15 35.98 35.33 49.07 62.02 57.26 101 58.08 43.28 56.99 39.11 87.89 102.4 110.6 97.85 107.54 111.6 84.78 93.11 PGD2 9.1 5.8 12.5 8 11.6 14.5 9 6.4 6.7 15.1 20.1 21.7 20.1 18.6 21.8 20.3 17 21.9 14.6 20.9 15.7 26.2 15.2 15.6 22 9.4 15.8 2.4 3.3 7.2 5.2 1.2 2.8 6 1.8 7.2 PGE2 11.3 8.4 14.8 15.3 14.6 15.5 8 11.5 8 16.4 15 9.3 17.4 24.7 16.8 17.6 14.3 18.5 29.1 42.3 28.7 29.8 28.5 26.1 25.2 34.9 34.8 3.4 3.6 8.9 2.9 4.5 2.2 3.5 2.2 5.3 PGJ2 3.7 1.2 2.3 2.2 3.7 3.8 2.4 1.4 2.5 0.2 0.7 0.8 0.1 0.2 0.2 0.5 2.3 0.4 2 2.7 5.2 2.6 2.4 1.9 1.9 3.3 1.7 2.4 2.3 2.9 2.2 2.5 2.1 2.7 1.6 2.1 PI(34:1) 5.89 5.71 4.45 4.62 5.28 5.54 5.1 6.1 6.23 7.92 6.7 6.87 6.6 7.27 7.18 7.49 5.12 7.12 5.41 4.54 5.83 5.47 4.8 5.04 6.69 5.71 6.05 6.49 6.59 7.51 6.02 6.82 PI(34:2) 5.38 4.19 6.05 4.06 4.56 4.71 4.5 4.9 5.13 4.61 4.39 4.8 4.8 4.81 4.77 4.95 6.29 4.35 4.94 4.28 4.3 5.3 4.37 4.63 4.08 4.39 4.83 4.64 5.05 4.61 4.65 4.77 PI(36:0) 1.17 1.01 1.34 0.91 0.95 0.9 0.89 0.89 1.59 1.43 1.71 1.66 1.47 1.49 1.3 1.65 0.48 1.03 0.83 0.79 1.14 1.26 1.28 1.18 1.18 1.31 1.47 1.29 1.33 1.09 1.27 1.1 PI(36:1) 8.03 8.61 7.45 7.43 8.08 8.09 7.12 7.11 8.41 9.27 8.35 9.43 7.9 8.68 9.46 7.49 7.38 8 7.6 6.02 8.55 6.92 7.39 9.16 6.88 6.94 7.22 6.6 7.59 7.47 7.51 7.55 PI(36:2) 17.51 17.25 20.87 20.07 18.72 18.15 21.71 17.19 14.7 16.59 14.38 16.16 16.17 14.08 15.6 15.16 21.88 16.12 21.94 23.78 20.79 16.45 16.14 19.97 13.13 14.16 12.45 13.34 13.58 14.4 13.45 15.67 PI(36:3) 9.8 10.54 13.32 12.79 10.42 11.31 10.77 12.8 8.91 7.7 8.05 8.77 7.91 9.39 8.38 9.09 11.97 13.41 11.5 9.38 11.61 12 9.62 9.91 8.3 7.24 8.29 8.4 7.66 8.74 7.61 8.53 PI(36:4) 8.91 9.51 11.21 11.16 11.75 9.81 9.59 10.44 7.52 8.39 6.92 7.75 7.87 9.13 10.01 9.26 12.15 16.25 13.01 10.31 9.59 11.34 10.09 11.82 9.99 10.54 11.1 10.21 12.01 10.7 11.08 10.64 PI(36:5) 0.74 0.7 0.95 0.57 0.6 0.58 0.57 0.58 1.31 1.16 1.35 1.37 1.29 1.29 1.34 1.52 0.57 0.94 0.61 0.58 0.57 0.75 0.63 0.63 1.36 1.23 1.35 1.34 1.34 1.31 1.37 1.56 PI(38:1) 0.23 0.1 0.32 0.33 0.27 0.28 0.21 0.33 0.29 0.48 0.16 0.4 0.24 0.38 0.32 0.42 0.07 0.28 0.31 0.03 0.21 0.25 0.19 0.33 0.04 0.15 0.03 0.02 0.15 0.13 0.1 PI(38:2) 2.13 1.65 1.71 1.36 2.06 1.54 1.86 1.87 6.33 5.15 5.18 5.56 5.12 5.74 4.58 4.67 1.7 1.1 1.26 1.36 1.76 2.67 1.75 2.11 4.22 3.58 3.46 3.26 3.34 2.95 3.34 4.33 PI(38:3) 25.94 22.23 24.85 21.95 20.32 15.48 25.3 17.61 35.59 45.37 39.06 36.81 37 29.87 40.29 35.99 16.32 14.14 16.02 20.63 22.59 34.01 31.93 19.08 36.95 34.05 28.43 33.51 34.72 29.14 29.97 37.96 PI(38:4) 117.26 112.74 116.03 104.14 106.08 110.7 105.05 110.13 90.78 90.41 87.81 87.67 94.45 91.62 99.85 98.86 109.6 112.15 114.78 111.44 108.11 130.38 116.3 110.41 94.7 103.28 95.32 105.15 102.63 104.14 94.08 103.49 PI(38:5) 13.95 14.45 13.01 13.69 12.02 11.84 15.24 12.83 20.86 22.44 21.08 20.15 27.28 21.66 23.97 25.21 15.31 16.06 15.5 12.39 13.18 11.5 13.89 14.2 21.38 20.67 23.05 23.47 23.37 21.06 22.84 22.14 PI(38:6) 1.52 1.99 1.99 1.72 2.08 1.52 1.63 1.71 3.46 3.93 2.95 3.37 4.18 3.6 3.37 3.47 1.92 2.13 2.15 2.06 1.98 1.75 2.11 2.19 3.48 3.57 3.39 3.74 3.57 3.41 3.75 3.26 PI(40:3) 1.1 1.51 2.29 1.32 1.9 1.29 1.34 2.2 1.32 1.15 1.15 0.93 1.12 1.09 0.81 1.17 1.41 1.12 0.94 1.37 1.12 1.85 1.93 1.36 1.23 1.17 1.1 1.11 1.15 1.05 1 1 PI(40:4) 8.51 7.14 9.33 7.97 6.46 8.97 8.92 8.86 3.28 3.33 3.04 4.25 3.26 3.44 4.11 3.38 8.56 7.43 5.67 7.92 10.12 8.75 7.83 7.75 2.78 3.02 3.26 3.38 3.55 3.14 3.17 3.14 PI(40:5) 4.72 4.81 4.96 4.49 5.29 4.27 4.48 5.1 5.82 6.4 5.65 5.97 6.67 6.1 6.15 6.34 4.1 3.64 4.15 4.45 5.27 4.77 4.74 5.21 4.5 4.66 4.13 4.61 4.17 5.34 4.86 5.07 PI(40:6) 2.97 2.97 2.92 3.21 2.8 2.98 3.3 2.87 4.53 4.79 4.44 4.45 5.08 4.58 4.47 4.77 2.79 2.72 3.03 2.85 3.46 3.45 3.44 3.49 3.89 3.89 3.95 4.03 4.18 3.65 4.23 3.92 PI(40:7) 0.87 0.93 1.03 1.11 1.11 0.88 0.87 0.88 1.65 1.67 1.45 1.44 1.87 1.58 1.77 1.54 1.05 0.79 0.58 1.11 1.01 1.14 1.12 1.19 1.11 1.1 1.35 1.31 1.13 1.39 1.11 1.12 PS(32:0) 41.61 36.63 36.98 37.31 47.4 49.03 45.16 47.45 24 21.25 23.16 21.72 30.63 30.1 33.7 28.75 36.84 52.45 38.43 40.79 32.68 39.64 42.72 38.84 20.39 20.22 18.78 20.45 25.15 27.66 23.04 25.91 PS(32:1) 7.29 6.31 7.29 5.99 8.04 9.22 8.27 7.13 16.2 15.33 14.62 14.54 18.72 17.22 18.48 21.95 7.37 7.8 10.13 6.93 8.63 7.53 8.71 7.72 13.83 15.52 15.25 15.41 16.2 17.69 16.08 17.89 PS(34:0) 67.59 66.72 63.99 65.05 75.82 70.13 67.53 75.37 43.04 40.32 38.32 40.67 56.53 48.64 47.85 53.69 67.9 68 92.42 54.1 69.56 54.73 60.8 69.07 35.93 39.87 35.51 32.25 37.68 43.48 41.93 39.54 PS(34:1) 109.58 93.47 94.13 107.26 102.26 102.25 112.1 113.58 111.23 102.8 107.15 117.07 127.41 143.05 120.45 128.88 102.33 94.62 144.16 85.45 95.37 99.35 85.06 81.08 110.82 106.09 103.89 97.31 113.66 133.14 123.66 111.49 PS(34:2) 27.95 29.44 32.01 33.65 33.62 30.26 30.37 33.46 31.08 29.33 27.43 29.4 30.6 38.01 32.54 32.35 27.43 38.01 29.14 25.46 29.11 23.92 27.32 25.79 27.76 26.05 30 28.43 31.23 32.2 35.92 32.83 PS(36:0) 30.66 38.46 48.29 35.06 30.96 32.36 24.07 36.08 37.8 48.67 42.19 53.27 46.6 50.75 48.72 47.69 45.24 34.33 33.88 29.39 42.17 38.74 47.23 37.42 21.17 29.22 27.98 34.44 29.11 45.93 27.72 24.93 PS(36:1) 241.72 188.37 253.6 231.09 216.25 207.85 187.24 214.1 197.11 205.67 208.09 226.94 238.27 197.51 225.11 210.24 238.72 239.78 300.38 164.69 217.82 180.89 195.68 243.01 190.54 192.14 200.44 182.64 201.47 219.6 205.58 233.15 PS(36:2) 241.43 247.22 263.55 243.24 242.68 213.1 225.19 242.65 151.9 146.69 143.97 162.51 156.21 145.25 175.34 153.17 179.03 224.83 309.65 242.45 182.7 217.51 159.86 225.97 130.23 139.3 145.48 149.16 175.22 152.78 162.51 163.77 PS(36:3) 23.71 23.32 24.83 27.95 27.01 23.1 26.52 23.85 31.38 33.47 37.2 36.25 36.52 39.26 37.84 43.66 23.75 32.53 24.28 20.3 23.21 20.95 20.68 23.01 29.55 32.82 32.68 31.65 39.79 37.06 34.65 33.82 PS(36:4) 15.56 15.38 24.45 16.47 17.37 15.94 17.44 15.06 12.22 14.79 12.96 13.17 17.73 15.73 15.41 14.54 19.27 16.99 25.01 15.06 13.63 17.27 17.83 14.54 16.75 14.79 16.15 15.14 18.11 17.13 15.76 16.53 PS(38:0) 1.97 1.88 2.31 1.82 1.55 2.08 1.55 2.19 2.48 2.71 2.29 2.36 2.96 2.78 3.18 2.33 2.21 1.63 2.4 2.5 2.01 1.82 1.84 2.43 3.27 1.55 1.61 1.37 1.25 1.59 1.83 1.6 PS(38:1) 9.4 8.2 6.57 10.06 6.43 6.7 6.93 7.83 6.64 7.52 7.07 7.74 7.27 7.66 8.73 9.47 5.69 8.91 7.64 7.52 9.3 6.35 7.06 9.63 8.02 7.29 7.49 7.14 6.8 8.48 7.92 7.51 PS(38:2) 22.15 21.95 31.03 24.66 24.14 23.33 19.74 20.65 26.89 22.73 22.15 21.99 23.38 27.32 22.31 24.43 16.04 20.81 24.6 26.42 26.53 18.34 20.59 22.82 15.15 13.76 15.01 16.92 16.25 16.66 13.79 16.77 PS(38:3) 88.31 79.42 71.34 69.54 52.26 69.26 73.36 64.22 75.4 83.59 79.07 74.49 89.67 94.46 85.34 95.51 88.87 92.36 77.81 58.18 68.51 76.51 93.79 75.31 74.99 69.21 67.5 71.29 72.22 80.18 69.39 70.96 PS(38:4) 150.52 201.91 134.59 160.47 137.5 142.8 100.41 132.22 86.2 96.87 89.82 95.06 106.55 99.93 107.55 111.66 194.07 133.32 239.05 200.18 125.16 169.44 183.5 143.44 91.31 108.3 95.18 99.59 108.32 109.66 96.71 107.16 PS(38:5) 34.2 21.2 16.6 19.89 23.1 19.7 20.8 24.61 39.07 36.45 37.96 39.03 42.4 45.57 40.82 49.53 17.85 23.58 26.55 28.01 20.53 22.23 21.95 24.85 34.43 33.28 32.81 39.63 39.19 35.19 38.91 36.74 PS(40:2) 1.96 2.49 3.17 1.67 2.2 2.34 2.61 2.85 2.83 3.46 3.7 2.69 3.68 4.07 3.59 4.49 1.85 3.09 2.77 2.33 3.41 2.69 3.59 3.48 2.05 2.13 2.36 2.02 2.05 2.66 1.95 2.11 PS(40:3) 20.4 20.19 27.82 19.38 20.1 24.17 18.66 24.86 11.19 14 15.38 14.95 21.29 23.11 14.95 20.72 31.87 23.01 27.6 26.82 42.58 46.52 38.43 29.52 9.79 12.31 12.83 12.43 13.6 12.01 11.08 12.68 PS(40:4) 108.11 155.78 125.94 139.3 123.63 125.43 118.69 128.51 36.6 37.47 45.55 33.9 57.43 50.28 45.06 38.58 168.1 166.93 208.29 129.5 223.92 161.06 132.98 138.96 30.1 29.85 32.37 32.23 28.51 38.84 27.17 29.97 PS(40:5) 53.56 50.12 68.04 56.23 50.85 49.38 49.98 40.87 67.83 59.93 67.34 68.34 83.45 76.71 91.18 80.48 69.22 48.97 62.2 71.35 80.99 59.47 48.92 52.72 44.97 46.47 46.03 46.59 47.93 53.05 59.23 57.41 PS(40:6) 65.91 44.76 49.21 51.01 31.53 40.06 42.57 46.17 64.31 64.88 63.86 61.45 75.85 67.04 74.21 68.68 64.65 62.4 56.61 38.22 57.29 54.09 47.87 45.12 55.84 53.45 55.25 53.43 55.47 56.62 64.31 52.59 PS(40:7) 3.14 13.14 4.77 5.9 3.3 6.59 4.24 5.97 14.55 13.85 13.78 14.18 15.4 16.04 18.1 15.78 8.67 4.11 7.05 8.01 4.02 6.99 6.71 7.96 10.13 11.03 11.32 12.81 11.75 11.03 12.61 10.83 SM(d18:0/16:0) 1231.9 1355.7 1351.1 1569.5 1734.9 1746 1611.6 1740.1 1702.5 1437.8 479.9 1553.4 2020.8 1742.4 2005.5 1471.7 1498.6 1533.7 1414.8 1504.9 1467.5 1603.5 1620.1 1565.4 1561.2 1733.4 1464.8 1402.2 2284.3 1407.2 1763.8 1693.4 1874.4 1678.7 1702.7 1970.5 SM(d18:0/18:0) 26.6 23 26 29.1 27.2 32.3 30.6 30.5 30.3 38.5 30.1 9.7 40.1 33 41.8 29.6 32.6 29.3 23.7 22.3 26.2 31.4 27.2 24.3 33.2 26.8 32.2 28.3 29.8 52.2 29.9 35.1 31.5 37.1 27.6 34.2 SM(d18:0/20:0) 25.3 32.4 30.4 38.4 32 34.1 37.2 28.1 37.4 11.5 37 33.5 34 46.6 36.3 34.8 28.4 33.8 32 34.6 32.9 41.7 32.9 27.4 44.1 33.3 43.3 33.2 39.3 49.3 45.4 41.7 50.4 34.1 34.2 31.2 SM(d18:0/22:0) 34.5 30 25 35.9 36.8 45.3 35.3 38.9 33.9 40.4 35.8 17 37.5 31.6 43.1 34.6 31.1 29.4 29.4 26.4 34.1 34.3 50.6 35.7 45.6 39.3 35.2 130.5 32.9 40 43 40.5 33.9 51.6 41.2 37.8 SM(d18:0/24:0) 26.9 32.6 41.9 40.1 47.4 45.3 45.3 44.7 41 13 64.8 45.9 45.2 39.7 44.1 30.4 34 30.6 39.1 42.9 33.1 52.6 45.9 42.4 46.3 59.2 49.5 36.2 128 38.5 47.3 44.8 44.1 54.7 44.6 43.1 SM(d18:0/24:1) 785.1 671.7 720.3 871.4 923.4 1038.1 891.5 928.4 902.1 260.3 830 842.5 890.7 854.3 974.9 700.5 676.3 705.8 749.9 797.4 732.2 846.2 1044.4 856.3 944.6 1106.6 894.1 805.5 672.4 1787.8 881.8 845.2 866.5 988.1 800.8 831 SM(d18:0/26:0) 2.9 1.7 1.2 2.1 2.8 2.3 1.9 1.5 2.2 0.8 2.1 3 1.5 2.1 1.6 1.1 1.1 1.2 1.3 1.8 1.3 2.2 2.3 4.1 2.7 1.7 2.9 1.3 2.9 2 1.9 1.8 3.5 1.7 1 2 SM(d18:0/26:1) 4.2 3.9 6.3 5.2 5.7 7.2 4.7 5.3 5.8 1.4 4.1 8.9 4.8 4.2 4.8 3.3 3.9 3.3 3.6 3 4.6 5.5 5.6 7.4 8.7 4.7 5.9 2.6 14 3.9 3.2 3.9 4.3 2.7 3.4 3.8 SM(d18:1/16:0) 12333.3 11457 12031.3 13802.8 13981.8 16031.1 13221.5 14160.6 14605.3 13983.7 13583 4515.6 14881.9 16565.2 15510.2 13888.9 13117.6 12478.3 14077.7 14537.8 13434.8 14609.4 15284.6 14206.3 14786.6 16250 14184.4 11514.1 19168.6 12678.6 16479.8 16138.2 16241.1 14224.1 13717.9 13945.6 SM(d18:1/18:0) 171 158.3 169.9 168.7 174.3 203.4 183.2 192 192.1 214.6 71 209.3 260 229.5 228.2 180 197 187.9 177.7 172.3 163.9 171 208.9 176.2 181.6 222.7 192.1 170.4 389.1 196 196.1 214.2 207.4 199.7 206 204.1 SM(d18:1/20:0) 48.3 45.4 51.6 48.9 49.9 66.9 53.7 56.2 57.9 62.2 60.1 22.6 71.3 63.6 60.6 53 53 56.8 52.9 50.8 51.3 70.2 52.3 51.6 55 57 75.7 52.1 187.1 71 65 65.9 68.7 62.7 64.7 67.9 SM(d18:1/22:0) 336.7 337.5 299 359.2 373.4 451.3 365.8 383.2 390.8 435 455.5 160.1 469.6 405.5 459.2 334.8 357.4 361.8 339.3 349.6 309.6 530.1 387.9 387.7 556.8 400.7 417.7 473.2 1166.3 322.2 436.7 444.8 528.5 386.4 427.4 474.4 SM(d18:1/24:0) 774.8 846.7 882.8 912 962.5 1151.1 963.1 981.8 947.4 957.5 845.5 329.2 1000 846.5 1030.6 726.1 774.1 829.4 795.7 836.1 912.6 1219.5 949.2 968.3 1181.8 1010.6 1128 704.2 1893.8 888.4 930.5 924.4 1065 987.2 883.6 857.1 SM(d18:1/24:1) 4414.1 4333.3 3907.3 4542.3 4969.6 5805.1 4630.9 4927 4956.1 4514.2 4187 1543.5 5043.5 4448.8 4761.9 3665.2 4185.2 4117.6 4831.9 4521.7 4509.7 5748 5195.3 5119 5213.4 4929.1 5772.7 3352.1 6951.5 3857.1 4641.3 4157.3 4756.1 4288.8 4061.2 4401.7 SM(d18:1/26:0) 4.9 6.6 6.3 5.1 5.8 7.3 5.1 4.9 5.6 5.3 2.2 6.5 4.7 4 5.5 3.4 3.2 4.9 4 4.7 4.7 6.8 5.9 6 6.2 7.9 5.8 10.6 3.6 3.2 4.4 6.3 5 3.8 4.7 4.2 SM(d18:1/26:1) 24.1 19.3 21.4 22.9 24.4 29.8 23.1 24.4 23.3 18.8 20.4 8.3 21.9 23 19.4 18.9 20.1 17.8 20.2 20.7 18.4 29.3 25.4 24.6 26.9 23.9 28 18.3 15.5 41.1 18.4 18.9 22.5 18.5 20.9 20.1 Sphinganine 13.5 12.9 13.3 13.5 12.8 13.3 12.7 16 15.6 10.6 25.2 23.3 38.8 42 36.7 21.2 19.9 21.2 20 17.1 11.6 12.5 10.2 16 14.6 16.6 26 29.8 28.3 34.6 46 45.3 30.1 29.6 29.3 Sphinganine-1-phosphate 14 20.6 17.6 21.3 14 11.6 10.4 9.1 12 19.4 21.7 19.9 33.6 27.7 27.5 16.9 15.2 12.9 16.4 15.9 19.1 15.1 12.1 22.5 19 17.4 15.9 20.1 35.8 16.7 21.9 26.7 10 9.4 11.7 Sphingosine 236.3 292.5 262.6 221.8 209 221.3 178.4 244.7 226.8 265.2 216.4 293.7 505.6 411.5 443 279.5 295.7 294.3 287.9 241.7 215.3 271.2 188.7 311.2 283.1 257.4 252.8 337.3 438 274.1 447.6 540.8 263.1 294.4 263.1 Sphingosine-1-phosphate 384 579.9 461.9 335.4 307.5 446.2 209.5 307.7 238.2 339.5 401.2 382 685.8 484.4 545.3 347.7 235.5 337.3 504 343.2 387.9 293.4 274.3 472.5 426 360.2 275.5 448 711.4 238.5 504.6 614.6 232.4 191.9 141 Stearic acid 576.3 774 783.3 731.9 907.9 886.5 714.6 887.9 803.4 919.7 710.2 740.1 1196.2 1077.3 1212.5 940.7 789.8 784.1 1063.4 1375.4 860 903.4 1102.1 1347.3 1008.8 922 942.9 1431.6 1382.4 1380.5 1275.6 1160.9 1178.1 1134.1 1214.6 1021.9 Stearidonic acid 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.2 0.2 0.3 0.3 0.4 0.2 0.3 0.2 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.2 0.3 0.6 0.6 0.4 0.6 0.6 0.7 Tricosanoic acid 0.7 0.8 0.8 1 0.9 0.9 1 1.2 1.1 1.5 1.3 1.4 2 2.4 2.4 1.4 1.5 1.6 1.6 1.5 1.4 1.4 1.4 1.7 1.7 1.4 1.5 3.2 3.3 3.3 3.8 4.1 4.2 3 3.2 2.9 TXB2 57.1 26.6 43.2 20.5 42.4 40.2 32 38.8 28.3 32.5 69.8 26.5 78.5 126.8 31.1 24.6 49 13.7 15.6 30 16 32.8 21.1 26.2 35.3 84.6 17 11.6 14.3 8.6 9.7 6.8 17.6 13.5 9.8 17.6 Zymosterol 0.408 0.211 0.399 0.412 0.425 0.547 0.467 0.061 0.08 1.292 0.533 0.52 1.033 0.515 6.557 4.517 7.302 5.947 7.853 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name 10Z-Heptadecenoic acid 11(12)-EpETE 11-HETE 11Z,14Z-Eicosadienoic acid 12-HETE 12-Oxo-ETE 13,16,19-Docosatrienoic acid 13Z,16Z-Docosadienoic acid 14(15)-EpETE 15-Deoxy-delta-12,14-PGD2 15-Deoxy-delta-12,14-PGJ2 15S-HETE 2,3-Dinor-TXB2 20-HETE 22R-Hydroxycholesterol 24,25-Epoxycholesterol 24S-Hydroxycholesterol 25-Hydroxycholesterol 27-Hydroxycholesterol 4beta-Hydroxy-cholesterol 5,8,11-Eicosatrienoic acid 5-HETE 7,10,13,16,19-Docosapentaenoic acid 7alpha-Hydroxy-cholesterol 7-Dehydrocholesterol 7-Oxo-cholesterol 8(9)-EpETE 8-HETE Adrenic acid alpha-Linolenic acid Arachidic acid Arachidonic acid Arachidonoyl-EA Behenic acid Bishomo-gamma-linolenic acid CE(14:0) CE(14:1) CE(16:0) CE(16:1) CE(16:2) CE(18:0) CE(18:1) CE(18:2) CE(20:0) CE(20:1) CE(20:2) CE(20:4) CE(22:1) CE(22:6) Cer(d18:0/16:0) Cer(d18:0/18:0) Cer(d18:0/20:0) Cer(d18:0/22:0) Cer(d18:0/24:0) Cer(d18:0/24:1) Cer(d18:0/26:0) Cer(d18:0/26:1) Cer(d18:1/16:0) Cer(d18:1/18:0) Cer(d18:1/20:0) Cer(d18:1/22:0) Cer(d18:1/24:0) Cer(d18:1/24:1) Cer(d18:1/26:0) Cer(d18:1/26:1) Cerotic acid Cholestenone Cholesterol cis-Erucic acid CL(68:4) CL(68:5) CL(70:4) CL(70:5) CL(70:6) CL(72:4) CL(72:5) CL(72:6) CL(72:7) CL(72:8) CL(74:6) CL(74:7) CL(74:8) CL(74:9) Coenzyme Q9 Desmosterol DHA Dolichol-18 Dolichol-19 Dolichol-20 EPA gamma-Linolenic acid GlcCer(d18:0/16:0) GlcCer(d18:0/18:0) GlcCer(d18:0/20:0) GlcCer(d18:0/22:0) GlcCer(d18:0/24:0) GlcCer(d18:0/24:1) GlcCer(d18:0/26:0) GlcCer(d18:0/26:1) GlcCer(d18:1/16:0) GlcCer(d18:1/18:0) GlcCer(d18:1/20:0) GlcCer(d18:1/22:0) GlcCer(d18:1/24:0) GlcCer(d18:1/24:1) GlcCer(d18:1/26:0) GlcCer(d18:1/26:1) Lanosterol Lauric acid Lignoceric acid Linoleic acid LTE4 Margaric acid Myristic acid Nervonic acid Oleic acid PA(32:0) PA(32:1) PA(34:0) PA(34:1) PA(34:2) PA(36:0) PA(36:1) PA(36:2) PA(36:3) PA(36:4) PA(38:2) PA(38:3) PA(38:4) PA(40:3) PA(40:4) PA(40:5) PA(40:6) Palmitic acid Palmitoleic acid PC(32:0) PC(32:1) PC(32:2) PC(34:0) PC(34:1) PC(34:2) PC(34:3) PC(36:0) PC(36:1) PC(36:2) PC(36:3) PC(36:4) PC(38:2) PC(38:3) PC(38:4) PC(38:5) PC(38:6) PC(40:3) PC(40:4) PC(40:5) PC(40:6) PC(P-36:0)/PC(O-36:1) PC(P-36:1)/PC(O-36:2) PC(P-36:2)/PC(O-36:3) PC(P-36:3)/PC(O-36:4) PC(P-36:4)/PC(O-36:5) PC(P-38:1)/PC(O-38:2) PC(P-38:2)/PC(O-38:3) PC(P-38:4)/PC(O-38:5) PC(P-38:5)/PC(O-38:6) PE(32:0) PE(32:1) PE(32:2) PE(34:0) PE(34:1) PE(34:2) PE(36:1) PE(36:2) PE(36:3) PE(36:4) PE(38:3) PE(38:4) PE(38:5) PE(38:6) PE(40:5) PE(40:6) PE(O-32:0) PE(P-36:0)/PE(O-36:1) PE(P-36:1)/PE(O-36:2) PE(P-36:2)/PE(O-36:3) PE(P-36:3)/PE(O-36:4) PE(P-36:4)/PE(O-36:5) PE(P-38:1)/PE(O-38:2) PE(P-38:2)/PE(O-38:3) PE(P-38:4)/PE(O-38:5) Pentadecylic acid PG(34:2) PG(36:1) PG(36:2) PG(36:3) PG(38:2) PG(38:3) PG(38:4) PG(38:5) PG(40:4) PG(40:5) PG(40:6) PG(40:7) PG(40:8) PGD2 PGE2 PGJ2 PI(34:1) PI(34:2) PI(36:0) PI(36:1) PI(36:2) PI(36:3) PI(36:4) PI(36:5) PI(38:1) PI(38:2) PI(38:3) PI(38:4) PI(38:5) PI(38:6) PI(40:3) PI(40:4) PI(40:5) PI(40:6) PI(40:7) PS(32:0) PS(32:1) PS(34:0) PS(34:1) PS(34:2) PS(36:0) PS(36:1) PS(36:2) PS(36:3) PS(36:4) PS(38:0) PS(38:1) PS(38:2) PS(38:3) PS(38:4) PS(38:5) PS(40:2) PS(40:3) PS(40:4) PS(40:5) PS(40:6) PS(40:7) SM(d18:0/16:0) SM(d18:0/18:0) SM(d18:0/20:0) SM(d18:0/22:0) SM(d18:0/24:0) SM(d18:0/24:1) SM(d18:0/26:0) SM(d18:0/26:1) SM(d18:1/16:0) SM(d18:1/18:0) SM(d18:1/20:0) SM(d18:1/22:0) SM(d18:1/24:0) SM(d18:1/24:1) SM(d18:1/26:0) SM(d18:1/26:1) Sphinganine Sphinganine-1-phosphate Sphingosine Sphingosine-1-phosphate Stearic acid Stearidonic acid Tricosanoic acid TXB2 Zymosterol METABOLITES_END #END