#METABOLOMICS WORKBENCH mchughce_20200409_121816_mwtab.txt DATATRACK_ID:1986 STUDY_ID:ST001354 ANALYSIS_ID:AN002253 PROJECT_ID:PR000924 VERSION 1 CREATED_ON April 9, 2020, 3:53 pm #PROJECT PR:PROJECT_TITLE 48 hours Post-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) Study PR:PROJECT_TYPE Quantitative NMR Metabolomics PR:PROJECT_SUMMARY To utilize existing serum samples from the phase II clinical trial of PR:PROJECT_SUMMARY L-carnitine treatment for severe sepsis to metabolically phenotype L-carnitine PR:PROJECT_SUMMARY responders and non-responders. Methods: Serum samples collected prior to (T0) PR:PROJECT_SUMMARY and after completion of the infusion (T24, T48) from patients randomized to PR:PROJECT_SUMMARY either low (6 g), intermediate (12g), high (18g) L-carnitine or placebo for the PR:PROJECT_SUMMARY treatment of vasopressor dependent septic shock were assayed by untargeted PR:PROJECT_SUMMARY 1H-nuclear magnetic resonance metabolomics. PR:INSTITUTE University of Michigan PR:LABORATORY Stringer NMR Metabolomics Laboratory PR:LAST_NAME McHugh PR:FIRST_NAME Cora PR:ADDRESS 428 Church St, Ann Arbor, MI, 48103, USA PR:EMAIL mchughce@med.umich.edu PR:PHONE 7343530164 PR:FUNDING_SOURCE GM111400 PR:CONTRIBUTORS Michael A. Puskarich, Cora McHugh, Alla Karnovsky, Alan E. Jones, Kathleen A. PR:CONTRIBUTORS Stringer #STUDY ST:STUDY_TITLE 48 hours post-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) ST:STUDY_TITLE Patients ST:STUDY_TYPE multiple timepoints; patients with severe sepsis or septic shock treated with ST:STUDY_TYPE varying doses of L-carnitine or a saline placebo ST:STUDY_SUMMARY phase II study of L-carnitine infusion for the treatment of ST:STUDY_SUMMARY vasopressor-dependent shock ST:INSTITUTE University of Michigan ST:DEPARTMENT Clinical Pharmacy ST:LABORATORY Stringer NMR Metabolomics Laboratory ST:LAST_NAME McHugh ST:FIRST_NAME Cora ST:ADDRESS 428 Church St, Ann Arbor, MI, 48103, USA ST:EMAIL mchughce@med.umich.edu ST:PHONE 7343530164 ST:NUM_GROUPS 4 ST:TOTAL_SUBJECTS 228 ST:NUM_MALES 128 ST:NUM_FEMALES 100 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:AGE_OR_AGE_RANGE 18-90+ SU:GENDER Male and female SU:HUMAN_RACE White, Black, Asian, Other SU:HUMAN_INCLUSION_CRITERIA Criteria for inclusion were as follows: (1) patients 18 years or older with SU:HUMAN_INCLUSION_CRITERIA confirmed or presumed infection; (2) the presence of 2 or more systemic SU:HUMAN_INCLUSION_CRITERIA inflammatory response criteria; (3) enrollment within 24 hours of recognition of SU:HUMAN_INCLUSION_CRITERIA septic shock with initiation of a standardized sepsis treatment pathway; (4) the SU:HUMAN_INCLUSION_CRITERIA use of high-dose vasopressors (norepinephrine bitartrate >0.05 μg/kg/min, SU:HUMAN_INCLUSION_CRITERIA dopamine hydrochloride >10 μg/kg/min, phenylephrine hydrochloride >0.4 SU:HUMAN_INCLUSION_CRITERIA μg/kg/min, epinephrine >0.05 μg/kg/min, or any vasopressin dose) to treat SU:HUMAN_INCLUSION_CRITERIA shock for at least 4 hours at the time of enrollment; (5) cumulative SOFA score SU:HUMAN_INCLUSION_CRITERIA of at least 6; (6) and blood lactate level exceeding 18 mg/dL SU:HUMAN_EXCLUSION_CRITERIA . Patients were excluded if they were pregnant or breastfeeding or had any of SU:HUMAN_EXCLUSION_CRITERIA the following characteristics: primary diagnosis other than sepsis, an SU:HUMAN_EXCLUSION_CRITERIA established do-not-resuscitate status or advance directive restricting SU:HUMAN_EXCLUSION_CRITERIA aggressive care, any history of seizures, known inborn error of metabolism, SU:HUMAN_EXCLUSION_CRITERIA anticipated surgery that would interfere with a 12-hour infusion, active SU:HUMAN_EXCLUSION_CRITERIA participation in another interventional trial, cardiopulmonary resuscitation SU:HUMAN_EXCLUSION_CRITERIA before enrollment, known allergy to levocarnitine, active warfarin treatment, or SU:HUMAN_EXCLUSION_CRITERIA severe immunocompromised state #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 10001 10001_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=38.27; Age=66; Sex=Female; RAW_FILE_NAME=DR_082 SUBJECT_SAMPLE_FACTORS 10002 10002_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=30.24; Age=62; Sex=Female; RAW_FILE_NAME=DR_129 SUBJECT_SAMPLE_FACTORS 10003 10003_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=32.28; Age=39; Sex=Male; RAW_FILE_NAME=DR_107 SUBJECT_SAMPLE_FACTORS 10004 10004_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=28.09; Age=72; Sex=Female; RAW_FILE_NAME=DR_027 SUBJECT_SAMPLE_FACTORS 10005 10005_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=24.52; Age=69; Sex=Female; RAW_FILE_NAME=DR_007 SUBJECT_SAMPLE_FACTORS 10006 10006_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=36.76; Age=70; Sex=Male; RAW_FILE_NAME=DR_051 SUBJECT_SAMPLE_FACTORS 10007 10007_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=NA; Age=62; Sex=Male; RAW_FILE_NAME=DR_141 SUBJECT_SAMPLE_FACTORS 10008 10008_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=29.25; Age=61; Sex=Male; RAW_FILE_NAME=DR_049 SUBJECT_SAMPLE_FACTORS 10009 10009_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=37.34; Age=71; Sex=Female; RAW_FILE_NAME=DR_011 SUBJECT_SAMPLE_FACTORS 10010 10010_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=21.07; Age=73; Sex=Male; RAW_FILE_NAME=DR_041 SUBJECT_SAMPLE_FACTORS 10011 10011_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=26.18; Age=54; Sex=Male; RAW_FILE_NAME=DR_037 SUBJECT_SAMPLE_FACTORS 10012 10012_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=20.93; Age=73; Sex=Male; RAW_FILE_NAME=DR_092 SUBJECT_SAMPLE_FACTORS 10013 10013_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=31.89; Age=60; Sex=Female; RAW_FILE_NAME=DR_059 SUBJECT_SAMPLE_FACTORS 10015 10015_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=43.34; Age=62; Sex=Male; RAW_FILE_NAME=DR_134 SUBJECT_SAMPLE_FACTORS 10016 10016_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=37.71; Age=48; Sex=Female; RAW_FILE_NAME=DR_116 SUBJECT_SAMPLE_FACTORS 10018 10018_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=37.18; Age=71; Sex=Female; RAW_FILE_NAME=DR_030 SUBJECT_SAMPLE_FACTORS 10019 10019_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=22.1; Age=77; Sex=Male; RAW_FILE_NAME=DR_139 SUBJECT_SAMPLE_FACTORS 10020 10020_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=38.38; Age=50; Sex=Female; RAW_FILE_NAME=DR_016 SUBJECT_SAMPLE_FACTORS 10021 10021_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=NA; Age=60; Sex=Male; RAW_FILE_NAME=R_151 SUBJECT_SAMPLE_FACTORS 10022 10022_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=29.61; Age=38; Sex=Male; RAW_FILE_NAME=R_320 SUBJECT_SAMPLE_FACTORS 10025 10025_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=38.79; Age=80; Sex=Female; RAW_FILE_NAME=R_441 SUBJECT_SAMPLE_FACTORS 10026 10026_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=27.47; Age=69; Sex=Female; RAW_FILE_NAME=R_021 SUBJECT_SAMPLE_FACTORS 10028 10028_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=26.65; Age=51; Sex=Male; RAW_FILE_NAME=R_505 SUBJECT_SAMPLE_FACTORS 10030 10030_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=30.88; Age=77; Sex=Female; RAW_FILE_NAME=R_303 SUBJECT_SAMPLE_FACTORS 10032 10032_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=28.42; Age=61; Sex=Male; RAW_FILE_NAME=R_486 SUBJECT_SAMPLE_FACTORS 10034 10034_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=28.41; Age=70; Sex=Male; RAW_FILE_NAME=R_238 SUBJECT_SAMPLE_FACTORS 10035 10035_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=29.28; Age=77.4; Sex=Female; RAW_FILE_NAME=R_098 SUBJECT_SAMPLE_FACTORS 10036 10036_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=24.89; Age=63; Sex=Female; RAW_FILE_NAME=R_315 SUBJECT_SAMPLE_FACTORS 10037 10037_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=23.62; Age=74; Sex=Male; RAW_FILE_NAME=R_109 SUBJECT_SAMPLE_FACTORS 10039 10039_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=40.87; Age=61; Sex=Male; RAW_FILE_NAME=R_084 SUBJECT_SAMPLE_FACTORS 10040 10040_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=42.45; Age=55; Sex=Female; RAW_FILE_NAME=R_197 SUBJECT_SAMPLE_FACTORS 10041 10041_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=24.36; Age=51; Sex=Female; RAW_FILE_NAME=R_453 SUBJECT_SAMPLE_FACTORS 10042 10042_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=17.79; Age=53; Sex=Female; RAW_FILE_NAME=R_041 SUBJECT_SAMPLE_FACTORS 10043 10043_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=38.84; Age=18; Sex=Female; RAW_FILE_NAME=R_335 SUBJECT_SAMPLE_FACTORS 10044 10044_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=40.37; Age=49; Sex=Female; RAW_FILE_NAME=R_212 SUBJECT_SAMPLE_FACTORS 10045 10045_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=39.3; Age=62; Sex=Female; RAW_FILE_NAME=R_179 SUBJECT_SAMPLE_FACTORS 10046 10046_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=22.42; Age=80; Sex=Male; RAW_FILE_NAME=R_321 SUBJECT_SAMPLE_FACTORS 10051 10051_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=30.12; Age=64; Sex=Female; RAW_FILE_NAME=R_192 SUBJECT_SAMPLE_FACTORS 10053 10053_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=34.83; Age=58; Sex=Male; RAW_FILE_NAME=R_024 SUBJECT_SAMPLE_FACTORS 10054 10054_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=28.72; Age=49; Sex=Female; RAW_FILE_NAME=R_512 SUBJECT_SAMPLE_FACTORS 10055 10055_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=31.68; Age=64; Sex=Male; RAW_FILE_NAME=R_440 SUBJECT_SAMPLE_FACTORS 10057 10057_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=19.38; Age=22; Sex=Female; RAW_FILE_NAME=R_122 SUBJECT_SAMPLE_FACTORS 10058 10058_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=20.66; Age=63; Sex=Male; RAW_FILE_NAME=R_056 SUBJECT_SAMPLE_FACTORS 10059 10059_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=34; Age=54; Sex=Female; RAW_FILE_NAME=R_022 SUBJECT_SAMPLE_FACTORS 10060 10060_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=42.7; Age=66; Sex=Male; RAW_FILE_NAME=R_426 SUBJECT_SAMPLE_FACTORS 10061 10061_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=27.44; Age=72; Sex=Male; RAW_FILE_NAME=R_289 SUBJECT_SAMPLE_FACTORS 10064 10064_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=44.29; Age=59; Sex=Male; RAW_FILE_NAME=R_166 SUBJECT_SAMPLE_FACTORS 10065 10065_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=19.17; Age=65; Sex=Female; RAW_FILE_NAME=R_535 SUBJECT_SAMPLE_FACTORS 10067 10067_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=35.87; Age=35; Sex=Male; RAW_FILE_NAME=R_226 SUBJECT_SAMPLE_FACTORS 10068 10068_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=18.3; Age=42; Sex=Male; RAW_FILE_NAME=R_338 SUBJECT_SAMPLE_FACTORS 10069 10069_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=31.4; Age=66; Sex=Female; RAW_FILE_NAME=R_423 SUBJECT_SAMPLE_FACTORS 10070 10070_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=27.72; Age=55; Sex=Male; RAW_FILE_NAME=R_220 SUBJECT_SAMPLE_FACTORS 10071 10071_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=19.47; Age=69; Sex=Male; RAW_FILE_NAME=R_014 SUBJECT_SAMPLE_FACTORS 10072 10072_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=35.74; Age=71; Sex=Male; RAW_FILE_NAME=R_475 SUBJECT_SAMPLE_FACTORS 10073 10073_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=14.52; Age=56; Sex=Male; RAW_FILE_NAME=R_127 SUBJECT_SAMPLE_FACTORS 20001 20001_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=28.72; Age=51; Sex=Male; RAW_FILE_NAME=DR_099 SUBJECT_SAMPLE_FACTORS 20005 20005_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=33.67; Age=69; Sex=Female; RAW_FILE_NAME=DR_104 SUBJECT_SAMPLE_FACTORS 20006 20006_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=26.95; Age=80; Sex=Female; RAW_FILE_NAME=R_431 SUBJECT_SAMPLE_FACTORS 20007 20007_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=26.78; Age=61; Sex=Female; RAW_FILE_NAME=R_049 SUBJECT_SAMPLE_FACTORS 20009 20009_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=26.55; Age=42; Sex=Male; RAW_FILE_NAME=R_500 SUBJECT_SAMPLE_FACTORS 20012 20012_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=18.11; Age=85; Sex=Male; RAW_FILE_NAME=R_189 SUBJECT_SAMPLE_FACTORS 20014 20014_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=22.09; Age=56; Sex=Male; RAW_FILE_NAME=R_370 SUBJECT_SAMPLE_FACTORS 20015 20015_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=40.65; Age=77; Sex=Female; RAW_FILE_NAME=R_466 SUBJECT_SAMPLE_FACTORS 20016 20016_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=22.51; Age=59; Sex=Male; RAW_FILE_NAME=R_141 SUBJECT_SAMPLE_FACTORS 20019 20019_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=33.84; Age=31; Sex=Female; RAW_FILE_NAME=R_548 SUBJECT_SAMPLE_FACTORS 20020 20020_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=24.7; Age=87; Sex=Male; RAW_FILE_NAME=R_319 SUBJECT_SAMPLE_FACTORS 20023 20023_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=26.51; Age=70; Sex=Male; RAW_FILE_NAME=R_136 SUBJECT_SAMPLE_FACTORS 20024 20024_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=36.53; Age=65; Sex=Male; RAW_FILE_NAME=R_010 SUBJECT_SAMPLE_FACTORS 20025 20025_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=24.71; Age=60; Sex=Male; RAW_FILE_NAME=R_551 SUBJECT_SAMPLE_FACTORS 21002 21002_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=20.06; Age=83; Sex=Female; RAW_FILE_NAME=R_302 SUBJECT_SAMPLE_FACTORS 21003 21003_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=19.68; Age=29; Sex=Female; RAW_FILE_NAME=R_011 SUBJECT_SAMPLE_FACTORS 21004 21004_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=46.66; Age=78; Sex=Female; RAW_FILE_NAME=R_219 SUBJECT_SAMPLE_FACTORS 21006 21006_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=51.28; Age=81; Sex=Male; RAW_FILE_NAME=R_039 SUBJECT_SAMPLE_FACTORS 21007 21007_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=25.23; Age=71; Sex=Male; RAW_FILE_NAME=R_134 SUBJECT_SAMPLE_FACTORS 21008 21008_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=19.41; Age=82; Sex=Male; RAW_FILE_NAME=R_280 SUBJECT_SAMPLE_FACTORS 21009 21009_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=23.63; Age=77; Sex=Male; RAW_FILE_NAME=R_222 SUBJECT_SAMPLE_FACTORS 21011 21011_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=36.01; Age=75; Sex=Female; RAW_FILE_NAME=R_079 SUBJECT_SAMPLE_FACTORS 21012 21012_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=26.48; Age=77; Sex=Female; RAW_FILE_NAME=R_227 SUBJECT_SAMPLE_FACTORS 21014 21014_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=28.62; Age=86; Sex=Male; RAW_FILE_NAME=R_265 SUBJECT_SAMPLE_FACTORS 22001 22001_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=22.14; Age=61; Sex=Male; RAW_FILE_NAME=R_587 SUBJECT_SAMPLE_FACTORS 22002 22002_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=21.96; Age=77; Sex=Male; RAW_FILE_NAME=R_258 SUBJECT_SAMPLE_FACTORS 22003 22003_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=34.38; Age=50; Sex=Male; RAW_FILE_NAME=R_009 SUBJECT_SAMPLE_FACTORS 22004 22004_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=25.72; Age=60; Sex=Male; RAW_FILE_NAME=R_490 SUBJECT_SAMPLE_FACTORS 22005 22005_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=23.32; Age=29; Sex=Female; RAW_FILE_NAME=R_517 SUBJECT_SAMPLE_FACTORS 23001 23001_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=21.97; Age=30; Sex=Male; RAW_FILE_NAME=R_142 SUBJECT_SAMPLE_FACTORS 23003 23003_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=25.29; Age=67; Sex=Male; RAW_FILE_NAME=R_080 SUBJECT_SAMPLE_FACTORS 23004 23004_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=32.46; Age=64; Sex=Male; RAW_FILE_NAME=R_126 SUBJECT_SAMPLE_FACTORS 23005 23005_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=38.09; Age=29; Sex=Male; RAW_FILE_NAME=R_460 SUBJECT_SAMPLE_FACTORS 30001 30001_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=21.22; Age=64; Sex=Male; RAW_FILE_NAME=DR_014 SUBJECT_SAMPLE_FACTORS 30002 30002_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=21.8; Age=32; Sex=Female; RAW_FILE_NAME=DR_114 SUBJECT_SAMPLE_FACTORS 30003 30003_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=40.88; Age=57; Sex=Female; RAW_FILE_NAME=R_527 SUBJECT_SAMPLE_FACTORS 31002 31002_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=33.21; Age=53; Sex=Male; RAW_FILE_NAME=DR_018 SUBJECT_SAMPLE_FACTORS 31003 31003_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=30.85; Age=21; Sex=Female; RAW_FILE_NAME=DR_113 SUBJECT_SAMPLE_FACTORS 31005 31005_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=32.53; Age=61; Sex=Male; RAW_FILE_NAME=R_094 SUBJECT_SAMPLE_FACTORS 31006 31006_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=41.16; Age=52; Sex=Male; RAW_FILE_NAME=R_336 SUBJECT_SAMPLE_FACTORS 31007 31007_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=35.9; Age=29; Sex=Female; RAW_FILE_NAME=R_006 SUBJECT_SAMPLE_FACTORS 40003 40003_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=29.32; Age=70; Sex=Male; RAW_FILE_NAME=R_065 SUBJECT_SAMPLE_FACTORS 50002 50002_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=31.15; Age=64; Sex=Female; RAW_FILE_NAME=DR_128 SUBJECT_SAMPLE_FACTORS 50004 50004_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=56.99; Age=71; Sex=Female; RAW_FILE_NAME=DR_077 SUBJECT_SAMPLE_FACTORS 50005 50005_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=21.94; Age=53; Sex=Female; RAW_FILE_NAME=DR_115 SUBJECT_SAMPLE_FACTORS 50006 50006_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=49.6; Age=60; Sex=Female; RAW_FILE_NAME=R_449 SUBJECT_SAMPLE_FACTORS 50007 50007_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=27.22; Age=68; Sex=Female; RAW_FILE_NAME=R_427 SUBJECT_SAMPLE_FACTORS 50008 50008_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=19.22; Age=45; Sex=Male; RAW_FILE_NAME=R_164 SUBJECT_SAMPLE_FACTORS 50009 50009_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=23.6; Age=84; Sex=Female; RAW_FILE_NAME=R_509 SUBJECT_SAMPLE_FACTORS 50010 50010_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=21.83; Age=56; Sex=Male; RAW_FILE_NAME=R_078 SUBJECT_SAMPLE_FACTORS 50011 50011_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=32.46; Age=61; Sex=Female; RAW_FILE_NAME=R_090 SUBJECT_SAMPLE_FACTORS 50012 50012_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=26.16; Age=43; Sex=Male; RAW_FILE_NAME=R_371 SUBJECT_SAMPLE_FACTORS 50013 50013_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=22.97; Age=69; Sex=Male; RAW_FILE_NAME=R_311 SUBJECT_SAMPLE_FACTORS 50015 50015_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=NA; Age=75; Sex=Female; RAW_FILE_NAME=R_108 SUBJECT_SAMPLE_FACTORS 50016 50016_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=NA; Age=78; Sex=Female; RAW_FILE_NAME=R_060 SUBJECT_SAMPLE_FACTORS 50019 50019_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=37.97; Age=63; Sex=Female; RAW_FILE_NAME=R_257 SUBJECT_SAMPLE_FACTORS 50021 50021_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=46.25; Age=36; Sex=Male; RAW_FILE_NAME=R_282 SUBJECT_SAMPLE_FACTORS 50022 50022_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=40.34; Age=56; Sex=Female; RAW_FILE_NAME=R_245 SUBJECT_SAMPLE_FACTORS 50023 50023_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=25.75; Age=70; Sex=Female; RAW_FILE_NAME=R_214 SUBJECT_SAMPLE_FACTORS 50024 50024_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=45.01; Age=48; Sex=Male; RAW_FILE_NAME=R_348 SUBJECT_SAMPLE_FACTORS 50025 50025_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=29.11; Age=41; Sex=Male; RAW_FILE_NAME=R_064 SUBJECT_SAMPLE_FACTORS 50026 50026_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=23.07; Age=63; Sex=Male; RAW_FILE_NAME=R_452 SUBJECT_SAMPLE_FACTORS 50027 50027_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=30.36; Age=46; Sex=Male; RAW_FILE_NAME=R_242 SUBJECT_SAMPLE_FACTORS 60001 60001_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=36.62; Age=46; Sex=Male; RAW_FILE_NAME=DR_055 SUBJECT_SAMPLE_FACTORS 60002 60002_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=31.08; Age=65; Sex=Male; RAW_FILE_NAME=DR_075 SUBJECT_SAMPLE_FACTORS 70001 70001_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=41.52; Age=59; Sex=Female; RAW_FILE_NAME=R_451 SUBJECT_SAMPLE_FACTORS 70002 70002_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=49.41; Age=54; Sex=Male; RAW_FILE_NAME=R_536 SUBJECT_SAMPLE_FACTORS 70003 70003_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=35.24; Age=66; Sex=Male; RAW_FILE_NAME=R_133 SUBJECT_SAMPLE_FACTORS 70004 70004_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=17.98; Age=42; Sex=Male; RAW_FILE_NAME=R_595 SUBJECT_SAMPLE_FACTORS 70005 70005_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=19.66; Age=32; Sex=Male; RAW_FILE_NAME=R_514 SUBJECT_SAMPLE_FACTORS 70007 70007_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=83.83; Age=64; Sex=Female; RAW_FILE_NAME=R_118 SUBJECT_SAMPLE_FACTORS 70008 70008_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=25.09; Age=61; Sex=Male; RAW_FILE_NAME=R_047 SUBJECT_SAMPLE_FACTORS 70009 70009_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=25.03; Age=66; Sex=Male; RAW_FILE_NAME=R_119 SUBJECT_SAMPLE_FACTORS 70010 70010_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=31.33; Age=59; Sex=Male; RAW_FILE_NAME=R_187 SUBJECT_SAMPLE_FACTORS 70011 70011_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=24.13; Age=41; Sex=Male; RAW_FILE_NAME=R_275 SUBJECT_SAMPLE_FACTORS 70012 70012_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=34.66; Age=59; Sex=Male; RAW_FILE_NAME=R_394 SUBJECT_SAMPLE_FACTORS 80003 80003_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=26.55; Age=48; Sex=Male; RAW_FILE_NAME=R_351 SUBJECT_SAMPLE_FACTORS 80004 80004_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=24.75; Age=60; Sex=Female; RAW_FILE_NAME=R_093 SUBJECT_SAMPLE_FACTORS 80005 80005_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=29.02; Age=70; Sex=Female; RAW_FILE_NAME=R_402 SUBJECT_SAMPLE_FACTORS 80006 80006_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=16; Age=65; Sex=Male; RAW_FILE_NAME=R_173 SUBJECT_SAMPLE_FACTORS 80008 80008_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=48.35; Age=39; Sex=Female; RAW_FILE_NAME=R_243 SUBJECT_SAMPLE_FACTORS 80009 80009_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=20.6; Age=66; Sex=Male; RAW_FILE_NAME=R_231 SUBJECT_SAMPLE_FACTORS 80010 80010_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=15.75; Age=54; Sex=Female; RAW_FILE_NAME=R_375 SUBJECT_SAMPLE_FACTORS 80012 80012_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=31.7; Age=68; Sex=Male; RAW_FILE_NAME=R_418 SUBJECT_SAMPLE_FACTORS 80013 80013_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=25.13; Age=49; Sex=Female; RAW_FILE_NAME=R_565 SUBJECT_SAMPLE_FACTORS 80014 80014_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=29.65; Age=77; Sex=Male; RAW_FILE_NAME=R_156 SUBJECT_SAMPLE_FACTORS 80015 80015_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=21.33; Age=91; Sex=Male; RAW_FILE_NAME=R_003 SUBJECT_SAMPLE_FACTORS 90003 90003_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=34.29; Age=86; Sex=Female; RAW_FILE_NAME=R_503 SUBJECT_SAMPLE_FACTORS 90004 90004_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=26.66; Age=46; Sex=Male; RAW_FILE_NAME=R_501 SUBJECT_SAMPLE_FACTORS 90006 90006_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=NA; Age=62; Sex=Male; RAW_FILE_NAME=R_235 SUBJECT_SAMPLE_FACTORS 90007 90007_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=22.46; Age=61; Sex=Female; RAW_FILE_NAME=R_433 SUBJECT_SAMPLE_FACTORS 91001 91001_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=22.14; Age=69; Sex=Male; RAW_FILE_NAME=R_175 SUBJECT_SAMPLE_FACTORS 91002 91002_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=17.96; Age=79; Sex=Male; RAW_FILE_NAME=R_293 SUBJECT_SAMPLE_FACTORS 91004 91004_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=35.31; Age=52; Sex=Male; RAW_FILE_NAME=R_131 SUBJECT_SAMPLE_FACTORS 91005 91005_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=32.72; Age=80; Sex=Male; RAW_FILE_NAME=R_146 SUBJECT_SAMPLE_FACTORS 91006 91006_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=19.13; Age=92; Sex=Male; RAW_FILE_NAME=R_557 SUBJECT_SAMPLE_FACTORS 91007 91007_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=20.66; Age=63; Sex=Male; RAW_FILE_NAME=R_209 SUBJECT_SAMPLE_FACTORS 100001 100001_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=29.26; Age=71; Sex=Male; RAW_FILE_NAME=R_184 SUBJECT_SAMPLE_FACTORS 100002 100002_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=25.01; Age=74; Sex=Female; RAW_FILE_NAME=R_202 SUBJECT_SAMPLE_FACTORS 100004 100004_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=30.84; Age=65; Sex=Male; RAW_FILE_NAME=R_195 SUBJECT_SAMPLE_FACTORS 100005 100005_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=26.61; Age=89; Sex=Male; RAW_FILE_NAME=R_478 SUBJECT_SAMPLE_FACTORS 110001 110001_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=23.32; Age=55; Sex=Male; RAW_FILE_NAME=R_248 SUBJECT_SAMPLE_FACTORS 110002 110002_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=39.67; Age=75; Sex=Female; RAW_FILE_NAME=R_381 SUBJECT_SAMPLE_FACTORS 110003 110003_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=21.92; Age=48; Sex=Male; RAW_FILE_NAME=R_193 SUBJECT_SAMPLE_FACTORS 110004 110004_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=26.41; Age=67; Sex=Female; RAW_FILE_NAME=R_470 SUBJECT_SAMPLE_FACTORS 110005 110005_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=22.07; Age=63; Sex=Female; RAW_FILE_NAME=R_326 SUBJECT_SAMPLE_FACTORS 110007 110007_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=39.99; Age=60; Sex=Female; RAW_FILE_NAME=R_072 SUBJECT_SAMPLE_FACTORS 110008 110008_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=36.79; Age=68; Sex=Male; RAW_FILE_NAME=R_464 SUBJECT_SAMPLE_FACTORS 110009 110009_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=29.59; Age=59; Sex=Male; RAW_FILE_NAME=R_599 SUBJECT_SAMPLE_FACTORS 110010 110010_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=19.39; Age=59; Sex=Female; RAW_FILE_NAME=R_396 SUBJECT_SAMPLE_FACTORS 110011 110011_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=24.9; Age=79; Sex=Male; RAW_FILE_NAME=R_483 SUBJECT_SAMPLE_FACTORS 110012 110012_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=21.53; Age=32; Sex=Male; RAW_FILE_NAME=R_144 SUBJECT_SAMPLE_FACTORS 110013 110013_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=23.41; Age=65; Sex=Male; RAW_FILE_NAME=R_255 SUBJECT_SAMPLE_FACTORS 110015 110015_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=29.03; Age=47; Sex=Male; RAW_FILE_NAME=R_531 SUBJECT_SAMPLE_FACTORS 110016 110016_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=17.02; Age=50; Sex=Female; RAW_FILE_NAME=R_027 SUBJECT_SAMPLE_FACTORS 110017 110017_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=25.5; Age=61; Sex=Male; RAW_FILE_NAME=R_333 SUBJECT_SAMPLE_FACTORS 110019 110019_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=40.04; Age=26; Sex=Female; RAW_FILE_NAME=R_239 SUBJECT_SAMPLE_FACTORS 110020 110020_T48 L-carnitine Dose (g):12 Timepoint=T48; BMI=47.25; Age=62; Sex=Female; RAW_FILE_NAME=R_331 SUBJECT_SAMPLE_FACTORS 110021 110021_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=27.62; Age=55; Sex=Male; RAW_FILE_NAME=R_182 SUBJECT_SAMPLE_FACTORS 110022 110022_T48 L-carnitine Dose (g):6 Timepoint=T48; BMI=32.4; Age=69; Sex=Female; RAW_FILE_NAME=R_157 SUBJECT_SAMPLE_FACTORS 110023 110023_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=23.63; Age=41; Sex=Female; RAW_FILE_NAME=R_487 SUBJECT_SAMPLE_FACTORS 110024 110024_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=25.42; Age=88; Sex=Male; RAW_FILE_NAME=R_286 SUBJECT_SAMPLE_FACTORS 110025 110025_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=21.92; Age=52; Sex=Female; RAW_FILE_NAME=R_277 SUBJECT_SAMPLE_FACTORS 110026 110026_T48 L-carnitine Dose (g):18 Timepoint=T48; BMI=31.24; Age=69; Sex=Female; RAW_FILE_NAME=R_586 SUBJECT_SAMPLE_FACTORS 110027 110027_T48 L-carnitine Dose (g):- Timepoint=T48; BMI=35.9; Age=51; Sex=Male; RAW_FILE_NAME=R_066 #COLLECTION CO:COLLECTION_SUMMARY Serum collected via existing intravenous or arterial catheter CO:COLLECTION_PROTOCOL_FILENAME mchughce_20200409_121816_PR_CO_235.1_NMR_of_CAPS_RACE_Human_Sepsis_Serum.pdf;mchughce_20200409_121816_PR_CO_Expt._235.1_Filtration_of_CaPS_RACE_Serums.pdf;mchughce_20200409_121816_PR_CO_235.01-Serum_MeOH_Precip_and_Resuspension.pdf CO:COLLECTION_PROTOCOL_COMMENTS T0: collected before carnitine or placebo administration, T24: collected 24h CO:COLLECTION_PROTOCOL_COMMENTS after administration of L-carnitine or placebo (±4h), T48: collected 48h after CO:COLLECTION_PROTOCOL_COMMENTS administration of L-carnitine or placebo (±4h) CO:SAMPLE_TYPE Blood (serum) CO:COLLECTION_METHOD via existing intravenous or arterial catheter CO:COLLECTION_FREQUENCY 1/timepoint, 5 collections/72h CO:STORAGE_CONDITIONS -80℃ CO:COLLECTION_VIALS SST: Becton-Dickinson 10mL vacutainer Serum Separator tubes CO:STORAGE_VIALS Sterile 1mL cryovials #TREATMENT TR:TREATMENT_SUMMARY Pharmacists and staff prepared either levocarnitine or placebo in identical TR:TREATMENT_SUMMARY polypropylene infusion bags with labels that included the study identification TR:TREATMENT_SUMMARY number, patient name, medical record number, and infusion rate. For each dose of TR:TREATMENT_SUMMARY levocarnitine, 33% of the total dose was administered as a 20-mL bolus over 2 to TR:TREATMENT_SUMMARY 3 minutes, followed by a fixed-rate continuous infusion of 1 L over the next 12 TR:TREATMENT_SUMMARY hours. The study solution was administered through intravenous (IV) catheters TR:TREATMENT_SUMMARY using US Food and Drug JAMA Network Open | Critical Care Medicine Effect of TR:TREATMENT_SUMMARY Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock JAMA TR:TREATMENT_SUMMARY Network Open. 2018;1(8):e186076. doi:10.1001/jamanetworkopen.2018.6076 TR:TREATMENT_SUMMARY (Reprinted) December 21, 2018 3/12 Downloaded From: https://jamanetwork.com/ by TR:TREATMENT_SUMMARY a University of Michigan User on 02/07/2020 Administration–approved medical TR:TREATMENT_SUMMARY equipment (IV tubing, IV pumps, etc). Levocarnitine was provided by Leadiant TR:TREATMENT_SUMMARY Biosciences (formerly Sigma-Tau Pharmaceuticals) and maintained by pharmacy TR:TREATMENT_SUMMARY staff, with tracking of lot numbers of levocarnitine administered. TR:TREATMENT_ROUTE Intravenous TR:TREATMENT_DOSE 0 (0.9% normal saline), 6, 12, 18g TR:TREATMENT_DOSEDURATION 12h (following initial 33% bolus) TR:TREATMENT_COMPOUND ). Levocarnitine was provided by Leadiant Biosciences (formerly Sigma-Tau TR:TREATMENT_COMPOUND Pharmaceuticals) #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Methanol precipitation, ultrafiltration SP:SAMPLEPREP_PROTOCOL_ID Methanol precipitation, Ultrafiltration SP:SAMPLEPREP_PROTOCOL_FILENAME 235.01-Serum_MeOH_Precip_and_Resuspension.pdf;Expt._235.1_Filtration_of_CaPS_RACE_Serums.pdf SP:PROCESSING_METHOD Methanol precipitation, dried by lyophilization, ultrafiltered SP:PROCESSING_STORAGE_CONDITIONS On ice SP:EXTRACTION_METHOD Methanol precipitation SP:EXTRACT_ENRICHMENT Lyophilization SP:SAMPLE_RESUSPENSION 500 uL 50mM sodium phosphate buffer in Deuterium Oxide (D2O) SP:SAMPLE_SPIKING CaFormate internal standard #ANALYSIS AN:DATA_FORMAT .fid #NMR NM:INSTRUMENT_NAME Varian 11.74T NM:INSTRUMENT_TYPE FT-NMR NM:NMR_EXPERIMENT_TYPE 1D-1H NM:NMR_COMMENTS Arrayed for water saturation frequency and 90deg. pulse width for each sample. NM:NMR_COMMENTS Varian (now Agilent, Inc., Santa Clara, CA) 11.74 Tesla (500 MHz) NMR NM:NMR_COMMENTS spectrometer NM:SPECTROMETER_FREQUENCY 500 MHz NM:NMR_PROBE 5-mm Agilent “One-probe NM:NMR_SOLVENT D20 NM:NMR_TUBE_SIZE 5mm NM:SHIMMING_METHOD Auto shim (gradient shimming) NM:PULSE_SEQUENCE 1 H,1 H-NOESY (commonly referred to as a 1D-NOESY or METNOESY) NM:WATER_SUPPRESSION saturation at 80 Hz induced field strength NM:PULSE_WIDTH ~5.5ms, arrayed for in each sample NM:TEMPERATURE 25 NM:NUMBER_OF_SCANS 32 #NMR_METABOLITE_DATA NMR_METABOLITE_DATA:UNITS μM NMR_METABOLITE_DATA_START Samples 10001_T48 10002_T48 10003_T48 10004_T48 10005_T48 10006_T48 10007_T48 10008_T48 10009_T48 10010_T48 10011_T48 10012_T48 10013_T48 10015_T48 10016_T48 10018_T48 10019_T48 10020_T48 10021_T48 10022_T48 10025_T48 10026_T48 10028_T48 10030_T48 10032_T48 10034_T48 10035_T48 10036_T48 10037_T48 10039_T48 10040_T48 10041_T48 10042_T48 10043_T48 10044_T48 10045_T48 10046_T48 10051_T48 10053_T48 10054_T48 10055_T48 10057_T48 10058_T48 10059_T48 10060_T48 10061_T48 10064_T48 10065_T48 10067_T48 10068_T48 10069_T48 10070_T48 10071_T48 10072_T48 10073_T48 20001_T48 20005_T48 20006_T48 20007_T48 20009_T48 20012_T48 20014_T48 20015_T48 20016_T48 20019_T48 20020_T48 20023_T48 20024_T48 20025_T48 21002_T48 21003_T48 21004_T48 21006_T48 21007_T48 21008_T48 21009_T48 21011_T48 21012_T48 21014_T48 22001_T48 22002_T48 22003_T48 22004_T48 22005_T48 23001_T48 23003_T48 23004_T48 23005_T48 30001_T48 30002_T48 30003_T48 31002_T48 31003_T48 31005_T48 31006_T48 31007_T48 40003_T48 50002_T48 50004_T48 50005_T48 50006_T48 50007_T48 50008_T48 50009_T48 50010_T48 50011_T48 50012_T48 50013_T48 50015_T48 50016_T48 50019_T48 50021_T48 50022_T48 50023_T48 50024_T48 50025_T48 50026_T48 50027_T48 60001_T48 60002_T48 70001_T48 70002_T48 70003_T48 70004_T48 70005_T48 70007_T48 70008_T48 70009_T48 70010_T48 70011_T48 70012_T48 80003_T48 80004_T48 80005_T48 80006_T48 80008_T48 80009_T48 80010_T48 80012_T48 80013_T48 80014_T48 80015_T48 90003_T48 90004_T48 90006_T48 90007_T48 91001_T48 91002_T48 91004_T48 91005_T48 91006_T48 91007_T48 100001_T48 100002_T48 100004_T48 100005_T48 110001_T48 110002_T48 110003_T48 110004_T48 110005_T48 110007_T48 110008_T48 110009_T48 110010_T48 110011_T48 110012_T48 110013_T48 110015_T48 110016_T48 110017_T48 110019_T48 110020_T48 110021_T48 110022_T48 110023_T48 110024_T48 110025_T48 110026_T48 110027_T48 Factors L-carnitine Dose (g):6 L-carnitine Dose (g):- L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):6 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):12 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):6 L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):6 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):12 L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):6 L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):6 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):12 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- L-carnitine Dose (g):12 L-carnitine Dose (g):18 L-carnitine Dose (g):6 L-carnitine Dose (g):- L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):18 L-carnitine Dose (g):- 2-Hydroxybutyric acid 60.54 97.73 111.5 482.8 119.58 36.62 106.67 76.4 28.9 38.39 316.13 61.96 80.56 71.27 139.78 75.18 58.33 70.23 127.2963801 69.70039702 68.79954143 101.6549456 164.8995141 63.02359438 159.6871352 74.23146067 98.28125 64.62730902 68.58694204 114.9586435 66.09611429 71.29834811 90.06 264.3421053 68.30842264 81.84448217 70.37706237 40.35384615 94.77357384 42 41.39278637 41.02459016 73.76470588 54.23318486 79.02588132 63.55284615 130.0869565 45.2105615 33.12698678 362.2014052 126.5359477 78.46358543 73.91363636 152.45635 31.45604396 133.5 34.87 36.2081158 236.6987238 110.9070724 133.7074094 92.29885057 35.33388158 43.74495968 110.3181963 44.49426129 111.51 58.01071705 24.80906921 269.1408935 149.9716294 58.20195652 99.825 72.83741899 345.2078313 109.002781 156.1314548 92.69512195 44.64602541 80.50879751 110.4696314 62.41523747 89.94768612 59.71287129 73.81043856 30.95876289 274.2024475 20.73 35.66 29.86134792 231.36 77.47 141.7545996 374.6616541 71.17931548 192.2736626 92.02 83.46 74.43 56.6560274 98.75190894 36.43292683 126.6531915 55.51807229 121.6545679 16.95190058 24.15114811 28.92431611 69.26203877 68.69164382 109.6762139 52.62865933 45.85757736 78.45377604 77.35159817 92.71420155 47.17573222 70.96 163.9 105.5133333 43.36330049 85.84577723 89.03758865 61.05901121 79.54292169 159.1120741 15.90980255 76.242375 157.7922374 103.950603 39.38238189 160.826546 112.4342629 63.11571181 14.12284946 146.0339431 55.30954015 72.10933667 121.0010716 110.2481777 72.49882838 26.19863889 65.3214375 225.2077295 31.62831325 58.60124844 28.51764706 190.6244545 59.3258427 50.43519737 48.09886696 110.3517455 56.48220875 43.2157398 39.67484536 51.95628866 58.69786905 89.93015625 68.88054113 109.9804964 27.28658537 238.573324 47.65625 48.05107527 94.13165266 91.08536585 52.86109628 65.56424581 202.733376 30.24852151 41.12170385 294.3134938 54.58559519 76.11839903 57.36863544 116.9359606 55.49678801 42.13358045 185.5098935 Ketoleucine 4.43 8.42 15.13 46.99 10.65 4.05 16.01 9.21 6.66 9.46 24.22 8.25 6.29 14.46 18.67 8.73 12.66 12.94117647 14.54275201 7.530298067 6.964341225 17.62993197 10.96870817 8.951720057 13.45955056 11.40625 14.54330446 11.23655914 19.86857143 13.21902312 19.8075 18.68421053 9.434865006 6.3638833 11.47008547 14.625 8.366627031 15.12124317 18.60294118 16.58084633 12.45790167 9.766473016 13.73061497 7.054821259 14.95576373 10.13276144 14.91316527 10.61136364 8.366507012 4.395604396 12.48 7.96 8.229117228 7.167350138 15.04373227 8.392269737 11.45213629 6.701149425 6.332236842 12.78310502 12.88705739 17.06785714 21.98187984 15.48316151 16.69469027 10.83413043 7.890720391 16.91746988 7.165795971 16.3566286 14.75609756 8.590780399 7.908271575 18.01650641 21.12763852 8.432595573 7.894164552 7.711340206 8.403480229 10.05 14.28 9.208345174 25.86 7.54 15.16504329 21.22807018 8.356481481 23.3127572 12.72 9.8 14.37 9.255068493 11.28231052 16.94840426 15.31851852 5.089322399 8.087841945 13.43364809 20.33551555 18.11806305 5.220708807 7.018229167 9.835515921 8.77 20.29 9.082926829 14.15640394 8.078335373 10.76855792 10.57093993 9.430346386 10.17203704 7.613279748 12.915375 26.043379 14.89179987 10.844424 18.13985617 9.621513944 13.06693548 6.792276423 5.605696637 7.64795995 18.14349033 10.02256161 17.6946293 6.147166667 12.8638125 23.53132045 6.497289157 8.977777778 10.79006346 14.83146067 12.48717105 12.41721491 10.64416443 15.28646934 14.61708846 6.890309278 5.315221346 11.12068359 23.95844909 20.16943359 12.5 16.54843866 7.65625 13.61904762 14.05317073 6.542214886 21.17178771 17.407289 9.836917563 8.98170326 12.15887665 8.646840509 12.03716904 13.55973825 17.14641328 12.05629561 3-Hydroxybutyric acid 324.05 47.22 44.88 2154.82 71.24 60.23 414.39 32.76 34.17 28.11 456.31 296.22 471.59 915.9 126.99 85.97 671.83 84.43 653.4049774 570.9667861 111.756469 23.86005831 1369.043507 510.9699562 28.68651685 46.875 213.0757519 122.8101266 161.0573477 35.49851429 576.7150406 45.6 94.73684211 223.9207961 84.47962649 26.57857143 27.21538462 121.4540169 152.625 130.5634166 43.1284153 265.1323529 106.5089087 53.10337885 76.57481017 342.9130435 47.08326362 474.3696331 519.9836601 45.41736695 100.2590909 377.5552291 430.6318681 120.89 71.54 84.19019934 138.5943846 564.8643092 72.57977285 693.7586207 84.72532895 84.16330645 161.4506164 64.43528694 35.27357143 28.52282946 25.33412888 232.1264605 287.3170224 550.2730435 361.4875 29.37775899 2887.248193 152.6865757 1374.287239 104.3658537 28.50577132 27.35484102 41.24831731 1015.739446 39.50827185 394.8193069 57.36426241 19.50515464 181.2973049 33.56 32.79 157.5942503 1010.11 60.09 108.4686147 4144.573935 36.4103836 1816.584362 63.16 128.74 76.49 32.76794521 59.20043835 57.92682927 82.24574468 156.7228916 133.9093827 51.65657895 30.44340126 74.29848024 41.74484053 88.35739669 60.05755592 125.2241637 22.15273737 682.2721354 46.37747336 43.68126188 39.22325164 18.92 522.26 51.01577236 26.22660099 404.1321909 124.7576832 1304.169991 299.8576807 111.7853333 27.72014678 54.300125 360.7773973 66.42910728 36.18613061 776.1628959 29.04780876 34.46276315 13.99086022 145.5957317 58.79752917 24.58272841 61.36768789 3449.097536 73.97338082 37.46844444 35.5843125 542.9527375 19.73704819 1478.040449 26.00915033 275.7888839 94.30337079 64.54407895 112.8967471 201.5874406 22.28197226 35.33522254 417.7527835 270.1461249 40.13116253 69.05851563 19.01050852 266.6424491 130.0304878 734.0611582 23.75 87.18860878 541.6976829 32.18769724 256.4518156 200.0959079 89.02410394 12.57674104 244.4585322 112.9223332 55.0253487 24.07433809 652.7470039 54.9732334 31.09255184 590.1826484 Alanine 104.28 349.94 264.75 3722.92 159.25 65.23 191.53 176.48 83.68 161.25 688.64 50.68 106.27 166.99 281.48 335.47 91.61 265.47 367.3303167 147.3927569 394.8272191 229.2123533 312.5667638 92.8621988 219.8946717 228.8123596 283.28125 136.4219324 303.6139241 113.518059 190.2084571 100.5489525 185.82 159.6052632 311.9795362 171.5943973 93.33695506 204.2717949 276.6645944 202.375 273.6767737 59.82752732 690.0882353 750.9741648 714.2530292 246.5680579 184.9673913 123.9104278 205.3566449 556.0824876 139.2636846 159.4691877 73.66969697 268.790638 49.17582418 137.58 102.3 109.2573564 158.610804 469.5564946 135.5674342 377.1768524 108.3563218 140.5756579 154.6875 135.7565753 146.0985348 329.9785714 276.1138566 123.2577566 976.6487973 123.7371161 162.763913 115.6375 192.7763689 430.1 141.6622742 146.714002 173.7195122 107.9054083 282.2345446 328.2481036 90.96174142 200.820702 182.5272277 165.251178 156.8350515 478.375893 138.74 314.33 126.2858767 227.52 193.33 239.8133117 223.8596491 281.1359127 305.1028807 258.78 388.43 245.89 123.0673973 109.4003818 193.1402439 1693.395213 95.13253012 256.3298765 204.2236842 83.46488734 90.33708207 225.1407129 368.6636207 221.7926896 282.3706289 325.5182491 121.4404297 303.3789954 426.9771029 157.7017334 706.04 1501.38 139.8770732 283.2770936 97.90942472 93.50260047 128.5868066 189.2902861 842.780037 218.6377774 383.8505 376.097032 445.878008 173.6249358 200.9571775 489.4143426 107.8776915 166.5704301 400.9634146 118.4670556 128.9227534 127.1378403 175.4616453 252.2713469 177.2433056 296.8700625 141.0435588 155.8123494 81.51660424 106.2810458 177.6506877 143.1235955 162.1710526 223.652595 104.052138 278.3951069 388.8145531 112.5787629 81.19000606 291.3619101 249.1989844 276.6940452 155.6471385 215.5487805 440.4642756 241.09375 189.0120968 158.3548086 95.37939024 377.3549546 117.2985335 569.5172634 114.968974 264.959432 674.0182533 123.9170621 203.4627774 144.9582485 120.2923314 204.5789615 168.6612302 997.0319635 Betaine 278.35 8.05 7.5 145.69 7.35 4.31 25.8 17.93 6.91 11.89 194.33 7.15 9.03 39.36 14.84 52.46 23.91 17.49 20.78054299 25.81010942 80.77956109 12.46250535 23.19727891 54.75058568 3.609564539 17.13033708 13.90625 10.32579186 31.42071952 27.22704715 16.42468571 34.73509267 33.915 15.52631579 40.50702043 26.6614601 20.33947015 7.299145299 31.32052012 20.375 123.0774871 5.522540984 40.27941176 126.7743875 37.12203024 14.29585181 24.63043478 4.688502674 14.56973956 74.91478012 26.44403595 6.270308123 28.90681818 25.76352953 55.90659341 22.55 15.32 47.47567632 45.65867495 5.281310267 21.56167763 168.3612764 23.51724138 10.63815789 646.3608871 20.70863014 13.29401709 25.28571429 13.93972868 29.53460621 66.77113402 17.67673087 22.17217391 28.325 9.468864469 58.5253012 7.992618583 32.05238332 25.62195122 21.21662432 52.11680612 12.32708333 27.57882586 7.49564051 65.75742574 5.262776368 32.77319588 89.01464243 30.78 16.26 21.96848063 18.74 11.86 12.08062771 14.19799499 19.54819775 23.3127572 9 115.23 10.01 4.252328767 9.507565045 182.0121951 64.50904255 35.27710843 478.3207407 359.1550152 31.11319575 60.38217078 14.9127114 26.49920786 4.515207617 44.11458333 16.07305936 59.30237541 31.27077107 33.69 50.11 26.94601626 17.58374384 16.5875153 68.81371158 26.97956309 38.95143072 21.30774074 8.882159706 13.60975 38.60547945 74.16700329 26.14076943 9.221938051 22.7250996 28.38886619 103.0836022 166.7394309 14.32566918 9.286808511 6.270176806 80.98229781 29.12241072 65.13069444 6.1813125 33.2037037 11.52349398 21.72184769 6.073202614 26.4613461 11.37078652 12.64934211 6.137244152 19.76773394 10.23416168 13.85445776 8.112783505 34.01741662 34.81257472 16.38914063 22.39594154 46.30090102 20.27439024 33.7863956 13.28125 29.40188172 11.6162465 32.40036585 102.843618 81.95530726 43.43030691 25.94487007 9.467883705 71.20277802 12.80562541 14.28038811 60.95417515 26.71671201 12.43442184 13.95992123 16.57534247 Carnitine 113.27 21.5 1959.58 16.3 20.77 55.06 22 33.93 235.81 351.63 18.05 17 111.01 21.84 38.13 142.01 214.6493213 30.26464607 94.8132984 585.9821143 73.17084548 88.49330656 137.7409828 62.13146067 414.0625 11.78355071 76.48700866 85.8588365 162.9222857 43.45402281 895.185 46.57894737 115.4813243 24.20771294 580.8216453 169.875 17.83412604 132 600.710245 10.19282864 26.61010039 35.15217391 79.03475936 203.3628911 25.69672131 203.1495098 746.9424242 32.80201955 28.66 19.42 42.15840057 71.05762904 88.82894737 15.3190914 5.436781609 46.35197368 21.29032258 50.36543379 36.08376068 70.16785714 27.87945736 431.8615752 81.40756014 40.96512233 71.68163043 11.9625 125.8873392 148.9042169 35.27776478 117.3051142 10.73170732 34.23295826 36.42990677 61.16129808 155.3123351 22.79923988 330.3707865 72.69072165 34.39202094 44.15 20.84 24.73098418 109.86 25.06 59.63203463 86.97994987 27.75545635 51.15226337 19.43 127.73 49.02 98.80410959 193.3204893 277.875 17.34939759 605.7197531 114.5254386 46.9142992 112.5443769 7.504690432 23.95898061 37.82405892 25.75969508 323.4017456 264.938151 71.15677321 504.2148309 20.08338314 137.31 15.52 102.7884553 26.37561576 131.2998776 332.5120567 16.88194884 392.247741 467.8066296 79.64661891 339.271625 19.91552511 144.8300537 48.51452841 187.4789604 97.1314741 67.07694896 437.5443548 557.9526423 17.31537406 188.9057523 481.2165915 189.9715062 81.08405556 212.0023125 31.03824477 59.70150602 109.0535948 204.8827526 51.41573034 21.08223684 64.5124269 81.6776699 128.1213405 503.844684 13.44721649 185.6341055 257.7097546 22.39594154 54.03885982 250.152439 525.8266384 14.6875 17.47311828 38.72082166 21.34 95.38549303 24.79219949 223.6669131 146.5709836 14.74587169 27.6598778 368.1267554 48.29791221 32.23472721 30.63926941 Choline 3.39 5.61 5.13 33.37 2.54 5.77 3.86 3.95 2.39 7.43 12.95 5.09 2.46 15.36 9.85 13.43 4.85 11.69 32.60180995 6.681804977 14.50100402 8.429213483 4.251796646 4.488674217 12.67714364 5.033371429 4.025542403 9.982562039 4.379487179 10.44017337 3.5 18.49464923 4.207650273 4.529411765 22.39905553 6.935611272 6.441358541 10.6049961 9.267769608 27.09154651 8.28 7.6 15.82522544 8.361908494 3.744243421 30.34072472 4.804597701 10.51151316 2.827620968 4.474086758 4.205250305 8.723571429 4.988066826 21.53127148 6.325 6.312576313 11.27831325 8.921797418 15.82926829 7.028820327 4.537532871 8.547823219 2.967024368 7.693069307 8.731958763 7.936620216 5.65 5.21 6.840484986 19.56 5.79 7.582521645 6.065162907 5.222800926 5.771604938 9.43 11.49 6.55 5.753150685 28.24734043 8.963855422 3.289969605 7.063052087 5.829514457 10.59968314 29.70214844 12.72450533 7.952480574 14.91 7.11495935 3.57635468 3.628830124 18.45067771 6.34439979 5.361872146 6.392502568 3.749579207 7.239043825 11.22350524 7.523387097 6.901829268 4.982841455 2.731414268 6.003360772 17.50607428 22.48692474 7.171694444 7.362560386 3.309939759 3.405592105 4.852704678 5.104854369 7.77278102 3.813153512 3.66742268 13.0222923 10.6459375 7.161492934 6.596292748 6.097560976 6.875 8.400537634 4.806722689 5.335 11.77598679 9.345071685 3.674104124 3.905088374 7.372935843 5.76456034 2.561099796 8.11509636 4.695609869 Citric acid 49.86 236.1 27.38 34.39 20.17 8.7 129.71 22.72 14.2 22.3 105.8 31.04 48.69 181.15 275.47 131.15 25.53 20.77 36.7081448 25.67909364 87.45414347 14.78395242 16.82488286 19.20288335 20.12134831 38.125 19.31530476 33.75483011 89.60435622 18.80891429 43.59465072 28.215 289.0842638 31.93174873 12.85254863 19.91623932 166.2307605 102.375 23.11831153 732.7941176 22.56837416 260.2317238 24.0326087 36.80776309 33.03864169 12.72773693 158.6218487 28.2969697 213.4123296 25.13736264 16.82 17.37 32.5366635 166.1763402 25.69325658 23.94537588 29.20689655 136.0164474 46.23991935 21.85910959 20.89059829 12.64285714 24.55536822 40.76426117 9.539823009 51.77706522 18.975 23.91495257 55.01987952 36.79360624 26.76539225 43.06097561 11.06388385 17.89084389 26.23456197 20.14453387 25.09405941 26.18231243 27.78350515 32.8358209 19.65 39.26 13.94406555 25.45 35.03 34.31412338 22.05513784 41.18551587 38.13786008 22.72 50.01 36.58 21.01150685 29.41006787 41.31097561 38.49521277 21.8313253 43.01950617 12.68055556 8.698114645 38.38297872 31.5822389 63.56746878 14.7771413 25.02018231 26.24464427 40.10416667 18.75190259 41.07774296 92.19 289.67 16.65203252 47.53571429 32.52876377 46.61997636 34.23722334 45.10165663 133.3072222 35.52863883 27.49725 44.27374429 65.99111316 26.14076943 63.43882659 32.98804781 29.57723734 47.78010753 66.27947154 16.81708991 26.22157697 14.0078418 48.91010066 64.14303121 32.34580556 14.00330113 19.49186747 26.25717853 19.80392157 49.19755125 27.56179775 24.48782895 36.96619152 25.41565792 38.6048124 53.89256963 26.11649485 75.62064843 53.08960938 30.20847928 60.63515256 29.42073171 27.16702013 15.78125 22.83193277 62.97902439 33.10360732 36.87988827 29.71547315 25.69894713 21.62068966 27.59595784 27.29279759 27.64368708 34.06262729 47.79472098 17.1326306 45.20547945 Creatine 141.78 159.72 88.5 201.09 89.14 13.44 137.03 61.46 17.84 23.52 301.1 139.08 93.42 149.1 173.8 62.63 21.17 32.46 65.57692308 33.01597753 26.35604324 743.3517897 68.39883382 56.23786814 213.253073 43.36966292 19.53125 116.620708 176.9037772 134.3115429 86.345534 317.9175 130.3947368 121.8984559 53.63293718 17.34470154 31.6991453 53.7088919 92.125 71.55667856 114.2640027 214.3382353 94.41870824 81.79430391 156.1220252 110.3586957 53.83135352 269.3397086 136.0508578 16.09943978 451.6537879 510.3569277 4.258241758 91.97 16.65 88.74786426 14.60015769 175.7235961 87.40871711 412.1281774 133.2643678 8.231907895 52.89314516 117.2210731 10.17399267 40.96285714 10.72286822 212.7804296 773.4323024 110.9705882 20.03054348 82.3625 121.3956983 73.76626506 120.0270825 219.4101291 423.6341463 81.48225045 430.28776 120.9002404 10.6444591 143.3541247 248.3762376 143.8053643 8.731958763 201.5279055 4.31 9.79 23.81014966 70.6 71.94 71.45562771 282.1679198 22.83110119 8.71399177 329.23 164.56 90.73 105.5578082 268.2401018 64.17682927 464.3074468 28.77108434 19.02049383 7.875292398 23.96608184 128.0346505 168.3864916 11.35627983 82.29105292 88.86478543 397.9026713 137.8580729 184.5053272 61.03805469 21.16168559 214.38 143 184.6861789 8.344827586 51.91676867 237.3022459 10.72871515 44.55496988 41.54474074 13.66486109 136.0975 61.73812785 15.62179006 8.78969103 155.2528472 26.66533865 71.30226858 19.66639785 382.5585366 52.81811942 66.78307885 227.1938532 491.6400555 338.5326647 16.53880556 59.3071875 91.95982287 13.85271084 145.4886392 52.67843137 143.8675128 22.49438202 13.78453947 52.80884503 20.63664532 7.125049268 31.77627926 23.78268041 181.78057 6.28560377 27.87554688 113.2817973 54.29256338 132.0121951 251.2604603 148.125 56.1155914 75.83940243 42.54987805 11.5142982 36.02618715 135.5658568 21.64121864 9.185260311 189.2666165 11.7708274 18.47279563 68.38136456 72.36335564 3.533993576 57.10876868 121.0502283 Creatinine 50.65 31.97 46.88 290.11 21.67 61.35 97.56 31.21 38.57 47.58 169.69 108.16 37.89 234.83 89.01 139.43 33.93 75.54 117.4660633 31.31277234 44.83950213 141.730453 35.65753158 38.85525435 78.54412437 25.83146067 151.40625 55.51631621 42.19353764 31.69285911 44.63805714 16.59409285 50.73 30.65789474 57.48977744 39.06213922 59.52102616 41.3965812 189.1991419 39.875 60.32778438 27.2182377 64.54411765 123.3200445 69.21056485 66.66679407 71.02173913 33.32185829 81.28381016 28.55191257 70.31147876 55.75490196 172.8310606 110.2254098 35.02747253 41.66 21.11 27.85239677 102.9974761 116.8289847 45.06003289 66.63061114 43.36781609 58.88980263 82.16733871 36.30401826 40.42466422 44.37642857 51.79145349 57.75656325 170.6776632 16.41410724 43.58847826 12.5125 23.91495257 50.90481928 58.980013 46.2611718 69.62195122 42.04275862 56.00612001 43.93498932 72.89841689 29.98256204 140.5816832 86.30953244 38.55670103 39.52748108 26.03 32.25 30.1244435 90.16 60.76 42.79626623 91.80451128 26.4124504 52.39711934 98.03 75.35 32.47 43.7739726 38.79086538 23.47560976 76.07074468 13.59036145 125.1012346 70.07675439 21.28262094 41.26170213 39.7123202 36.42319017 55.17703219 27.85498129 55.45239355 223.0794271 38.50837139 81.43228623 38.279737 44.88 32.02 26.18910569 67.20566502 54.28641371 180.7016548 28.24176487 392.3844127 121.8502963 136.653 48.56324201 130.3762479 46.11733995 85.22692198 32.52988048 29.31315486 52.39973118 106.375813 17.56451613 22.12445557 75.37552969 140.5831309 131.1122879 46.10375 125.7980625 14.43639291 34.93825301 42.48888889 36.57124183 78.09950695 46.84269663 34.86677632 115.3230994 166.5051436 44.69349087 99.39620154 49.45463918 34.41605822 202.7832478 121.5878125 37.10955429 22.07221035 146.9512195 172.3795694 50 26.20967742 27.63865546 17.69658537 24.59872797 20.14734637 43.0786445 98.36917563 29.95807978 65.34514546 17.85026572 28.56077623 19.33630346 69.14123961 21.72751606 24.74713309 100.6240487 Glucose 2994.31 3139.32 5796 4270.16 4268.18 2408.53 4283.85 4269.79 3261.64 4948.47 11823.62 2178.31 4790.73 5213.45 7038.39 11617.09 4367.52 11016.26 7067.997738 3001.702624 6036.218474 5268.707409 9636.944995 4279.655288 3700.814331 2986.252809 5098.59375 3487.809529 2777.412059 4256.495037 8147.836229 5252.5929 3622.635 4350.263158 6455.586234 5252.30764 3739.342958 5732.435897 13389.40635 3672.25 5783.100674 5753.435792 3360.985294 3261.820935 5171.66508 5573.825231 4522.793478 4585.523061 6021.136579 5218.60981 3486.164216 5343.488796 8196.241667 7774.344238 3853.296703 3699.32 3241.25 3067.814903 3612.211741 2701.790301 6957.449836 4676.784749 3778.942529 3273.639803 3043.019153 2932.572123 4679.62967 6478.958571 6133.695078 3456.46778 4478.504467 4671.988027 6328.14 2759.075 6012.000564 12372.15723 3993.277609 14054.80487 6660.768293 3869.625917 4002.881855 4733.6 2442.419525 3129.89839 4808.351485 3865.509242 3399.340206 3157.841126 4427.95 3490.83 3471.283035 6363.58 3523.93 4609.273539 7088.245614 3177.40286 6069.125514 4801.56 4760.79 7504.16 3187.245479 6348.391332 4203.963415 4410.395213 1906.120482 5374.502222 4427.783041 3266.604715 4149.611246 4600.062539 4050.868108 4426.363884 3976.729961 7439.36895 3498.211263 4203.439878 2506.89944 1557.877466 4128.58 5519.07 3390.95935 3598.557882 3553.175031 3383.297045 2107.561426 7130.571913 10294.95807 3758.129617 9343.78775 5508.021461 4840.710947 3544.071915 3476.366625 5312.541833 7164.953703 4349.837634 6611.952439 2286.875086 4018.183529 3388.563635 6454.796946 3432.880964 4222.225333 4263.936188 6066.461031 5417.268072 3840.828464 4474.498039 7923.117908 3982.741573 4872.753618 10882.61842 7822.591944 4009.20045 7006.669578 5664.945567 3914.26188 7164.717983 6127.297344 4313.822925 6027.362498 2514.329268 4470.146993 3981.25 4698.084677 4360.365079 3529.688049 5349.830801 7868.392458 5123.545396 3448.577375 6326.948614 3668.179679 4562.941838 9071.714809 3889.286151 2185.265936 4743.404711 4473.900938 3176.773212 Glutamine 228.1 307.72 325.88 819.26 165.47 155.44 446.13 198.48 138.96 233.7 1038.05 110.7 227.04 319.07 496.98 618.1 279.04 328.26 468.6199095 225.0851167 618.5113004 230.4341675 757.8219631 285.0934572 333.0906157 320.8539326 265.15625 259.6025552 438.0946036 263.9150813 526.5171429 421.4618329 200.925 561.1842105 1119.100788 265.6845501 268.6557009 335.4478632 322.2533514 436.625 852.9556084 167.5170765 1302.852941 790.2385301 874.5698649 240.4817051 295.5652174 312.9575535 402.8916402 850.8469945 250.2297794 305.5504202 215.1545455 338.6443314 277.3351648 355.54 221.38 290.5511391 300.2323336 455.1529212 260.6768092 575.1352082 225.4367816 268.8667763 521.1139113 355.2424886 291.2474969 523.1614286 290.804186 296.0023866 889.3140893 315.3753254 383.4778261 242.1375 250.0751385 425.3753012 330.040026 378.3502979 366.7560976 197.3276225 846.3147024 517.5794605 262.4020449 347.1418511 383.5544554 261.5599855 225.8969072 440.560232 160.91 485.28 287.3003694 185.93 423.43 425.0067641 387.7568922 397.2313161 370.627572 313.37 652.16 508.2 138.4508219 190.2780684 357.0121951 792.6335106 165.3975904 270.4995062 265.4907895 146.5724851 413.9878419 499.0619137 494.4136461 407.5237316 396.7486051 484.9615181 280.4785156 617.9756469 603.5824697 520.9548715 1145.65 972.16 185.4430894 369.1096059 101.6793146 161.6596927 248.1804254 304.2311747 442.4300741 297.8939717 454.815625 535.7276256 524.1329563 299.0777987 392.8950969 647.2988048 231.0721667 266.3543011 754.4904472 283.5236788 164.1579975 207.3160586 451.6834432 350.8206017 326.8243611 399.7805625 319.6217391 218.4560241 162.5558052 238.3071895 232.7570832 275.247191 279.2585526 436.8861477 233.1940921 331.8977496 665.7766031 142.9183505 322.2352941 381.5844996 261.5258594 294.4024641 420.6405144 311.5853659 655.0423636 431.5625 356.5188172 265.1708683 223.2892683 311.8019615 322.3575419 684.5108696 285.0246864 338.7241379 414.3298765 257.276656 537.9382899 328.5891039 205.4098963 371.7237687 355.3434496 715.2511416 Glycine 103.37 116.89 165.25 468.02 47.78 48.25 170.01 131.76 113.58 102.72 525.5 33.95 90.27 138.66 167.79 381.15 99.21 136.6 205.8144796 109.0051322 265.7852932 162.9900209 284.7300292 224.7655622 107.7094058 127.9337079 159.53125 109.088954 209.7108594 97.95974635 140.8019429 217.9732536 88.35 126.4473684 367.833937 167.7191851 83.10482897 90.61367521 138.3902981 229.5 301.1985731 54.69945355 281.9558824 432.9443207 478.5595966 135.5982775 121.2391304 65.13669786 144.9305672 253.8400989 90.94771242 90.66526611 68.79090909 170.517381 107.967033 117.2 86.26 123.689962 185.4220026 234.6182076 89.21628289 229.4889129 90.40229885 86.75164474 256.6481855 95.23413242 79.49279609 165.495 94.03955426 107.2434368 483.4859107 80.94820406 162.6379348 81.125 71.50206631 193.103012 104.868668 113.6703078 129.7195122 103.6100181 904.0061917 147.4508814 54.18997361 132.110664 159.3564356 97.2297934 82.10309278 273.2687275 71.79 197.54 113.1310978 107.81 114.51 134.0435606 118.5463659 174.7399967 140.2160494 120.75 404.98 118.84 63.28465753 33.84693156 225.9146341 523.8239362 61.30120482 73.52888889 78.08552632 80.96649271 160.7972644 179.7998749 298.4485735 111.4386252 204.5985351 206.9940492 124.9495443 369.1780822 205.5333548 179.4025702 376.73 447.7 115.0504065 167.6416256 47.71603427 83.39066194 140.1043978 114.3942018 379.3634444 160.5621178 162.48375 170.9671233 214.7631139 94.4035647 95.66493978 326.7649402 91.76866048 221.7419355 384.7495935 108.9996568 72.10933667 71.10647314 265.1301631 179.1581217 143.7266111 143.67375 167.4621578 83.97439759 114.2187266 93.87058824 117.0208073 74.40449438 84.32894737 148.5783991 108.7225367 117.7576325 213.0281762 52.23298969 121.3199272 186.6340812 129.0119531 94.53170673 141.3128869 132.4695122 193.754636 195 165.3225806 71.16619981 101.365 341.503617 102.9563547 366.4322251 114.6000896 291.102096 239.7724262 78.51529924 154.0709763 167.2398167 125.2597603 136.124197 174.4990154 360.304414 Histidine 25 44.17 67.5 134.1 20.92 16.54 51.33 44.36 31.03 27.44 110.39 21.1 26.94 41.15 43.87 63 36.03 29.56 65.70135747 25.02401472 70.33982968 47.28421147 70.78483965 28.35132195 39.99397509 28.14269663 32.8125 31.34181528 47.22085276 55.76445714 43.3133949 37.36842105 80.38504985 34.25687606 22.71032864 30.03076923 69.9491616 39.75 53.94272691 27.34972678 129.4117647 99.48507795 119.1680089 40.33977985 45.91304348 25.95421123 23.15821761 62.54228467 50.78737745 38.80812325 35.19245013 32.41758242 35.54 25.46 19.62327954 37.69495258 65.29619966 11.87828947 75.40562466 20.10344828 33.18092105 56.38608871 32.21342466 20.61929182 46.14642857 29.80957364 50.27446301 88.0604811 33.24908902 29.98282609 22 16.50981497 41.60783133 31.6948668 21.47840119 39.57317073 10.41306715 179.8159455 50.7306891 24.67579156 46.69159401 40.02227723 33.41862994 23.4742268 36.570701 20.01 47.97 24.99407976 55.41 39.61 55.96491228 34.91815476 43.45679012 43.73 64.54 32.73 20.88643836 20.66310803 151.9817073 110.3617021 23.13253012 46.46617284 39.24298246 26.64954274 55.10699088 57.37961226 44.45568078 42.97572286 47.94507841 52.48928855 30.20345052 52.07001522 54.67389732 42.32337119 103.15 123.2 24.22113821 44.55541872 27.25091799 11.81914894 43.70373671 35.53463855 85.01681481 44.9955 51.7803653 57.669225 25.11340294 41.75207117 39.03585657 36.70746419 46.19623656 76.46788618 23.66849691 29.22613267 30.81725196 46.37105172 48.90598931 21.36872222 36.2525625 24.83059581 36.28674699 45.83071161 36.43921569 36.22378447 33.24719101 21.24440789 53.37975146 27.6965503 30.83203138 68.76386833 23.11587629 20.46360218 39.84105774 25.91445313 28.64597174 45.53979032 41.00609756 87.15511027 37.96875 30.74596774 10.68160598 31.4895122 29.04743409 23.39141061 51.6943734 42.29874552 52.70926302 54.80140685 17.85026572 38.38673135 27.14765784 20.8094993 29.44274296 81.87214612 Isoleucine 21.87 24.52 38.88 114.87 47.87 27.75 41.12 48.18 18.85 33.12 118.46 13.58 28.72 56.66 64.2 44.93 46.53 77.09 54.25339367 67.86617604 33.03062561 50.46092852 52.62468416 49.26623159 40.715888 65.25842697 29.0625 30.61293585 65.53464357 31.40474221 49.93634286 29.95374388 96.31578947 43.40037903 16.58590832 49.53846412 20.43760684 46.05276477 45.875 40.51208878 29.0590847 18.76470588 109.7302046 61.99587219 49.26086957 16.07486631 25.30533713 132.0186053 48.56311275 39.31652661 56.59393939 49.40223188 26.51098901 50.32 39.09 39.4997627 79.3796937 40.92845395 51.46024878 33.25287356 19.12335526 49.72627854 45.03687424 64.09928571 47.28784884 15.88305489 73.66597938 38.43987507 28.09315217 35.475 20.51587302 107.2963855 29.76561404 61.95692651 27.09756098 22.77858439 43.30102797 43.46087073 32.09465699 25.14162754 55.86633663 35.12903226 33.79381443 49.48716135 35.18 50.67 28.28277446 69.09 59.41 74.92559524 109.7243108 44.16997354 93.7037037 48.73 51.02 58.91 26.76465753 28.3959276 47.95478723 19.37349398 15.1908642 35.23859649 11.38157555 16.72401216 22.67041901 41.82434765 58.29514457 51.14963378 52.77148902 45.49316406 76.51445967 35.58142524 31.00119546 49.04 60.74 29.82227642 39.1908867 18.74173807 15.62754137 61.05901121 38.40474398 51.82385185 50.36477372 52.355875 70.77671233 33.57954873 32.64742383 65.06026625 56.26294821 22.31496924 28.24569892 44.47845528 36.49931366 23.89987484 44.02464566 74.83512669 40.42731278 31.17491667 33.5795625 76.07979066 25.00843373 29.95705368 22.97254902 43.93097266 31.02247191 23.67697368 35.82437865 24.32951869 32.77522663 79.31359304 27.89463918 35.74486355 38.58393699 34.59929688 34.63558401 64.94811321 21.34146341 82.19057867 34.0625 41.33064516 45.26330532 15.61463415 39.51497791 55.83205307 61.36508951 20.41160394 43.9479378 37.619018 31.69068915 51.09496665 28.42820774 58.53510771 45.41836188 59.13930268 55.92085236 Lactic acid 1727.53 4100.43 1702 48742.81 2053.67 468.75 1450.86 1432.87 485.48 1110.1 3340.21 1512.51 1193.89 1145.51 1984.2 3165.41 870.56 1128.82 2681.68552 1266.267551 3548.652964 1910.917487 1224.683771 695.2115964 1598.459561 1279.337079 5591.5625 1473.186798 898.9916722 1360.055831 1092.374057 845.7362239 7190.4075 1044.473684 1958.174782 1428.713243 578.4894702 2007.682051 1691.888096 896.625 1223.068767 605.6386612 13579.33824 5497.471715 1700.944009 1595.332136 1379.902174 1599.449198 2445.569126 3539.485428 847.0741422 1337.439776 1229.210606 2024.030688 856.8681319 809.67 588.85 1819.141315 2257.582565 3980.187465 1897.944079 3494.835046 1269.298851 1057.736842 1092.958669 1035.687169 1133.925397 2638.943571 1465.708857 1204.355609 6833.033677 1292.225143 1220.981304 1189.65 2483.391801 2445.56506 1967.700013 2042.265516 1546.707317 1338.079129 1765.359574 2099.713194 824.9455805 1421.67315 593.4653465 1426.212396 1316.257732 3858.131145 989.24 1597.69 1081.454367 3529.99 2325.31 1324.242424 2500.225564 2088.374256 1887.541152 1303.06 1435.44 1603.4 1169.015205 2772.025665 3487.5 15175.39096 1439.421687 5175.233827 1531.544152 629.7805136 741.6139818 1795.966229 1971.007006 1907.606929 2227.289234 1592.598387 903.7223307 1133.820396 2564.466136 1215.786013 2675.19 8980.89 1398.316585 2874.942118 1166.080783 2174.723404 891.2722334 1524.435994 4449.249 1002.805591 3355.7755 2178.605251 2355.386347 1230.442592 1703.32236 1902.585657 1779.123642 1273.300269 2105.496138 1520.389499 2262.430438 1711.758268 885.8608122 2623.474552 1729.988333 3150.464625 1650.80153 2505.011446 1729.035206 1666.169935 2790.002123 1224.707865 1699.552632 1613.809759 918.3307168 2517.992411 1393.453398 832.5049485 1275.387362 1690.247204 3863.354688 2342.589443 1012.150381 2411.432927 2686.914824 1493.28125 2113.74328 1868.880486 1601.540976 2187.585813 1476.219972 4204.299872 934.384207 1493.80595 8187.538454 1492.049385 1496.95151 1159.665988 1664.759944 1329.959582 943.5637669 4287.656012 Leucine 28.12 49.42 67.25 224.91 73.88 36.02 85 67.91 40.33 40.68 151.87 25.95 45.13 91.55 100.9 75.18 55.42 114.09 75.90497738 108.2190375 53.91008844 47.77293717 108.4307094 54.93649598 78.97727212 103.5977528 29.6875 55.39483631 82.41205863 48.54769782 76.9576 65.11072026 39.1875 174.4736842 67.05044064 28.0565365 78.73745808 39.72820513 38.7446434 77.25 74.85929449 41.02459016 70.04411765 90.04320713 180.9541677 93.84306681 83.09782609 42.53141711 51.22413697 193.473198 79.08496732 58.80532213 53.78863636 70.11929686 30.90659341 85.22 50.31 50.6407214 23.62570971 117.1490641 44.41447368 114.0751758 68.02298851 42.42598684 30.60483871 86.92511416 69.9970696 100.3842857 90.28655039 38.32935561 150.9608247 77.5812077 46.86391304 63.25 32.53404715 173.5945783 46.85328135 87.400571 47.2195122 45.55716878 65.72940473 90.24057158 82.41391821 37.94668008 82.51732673 55.25915187 42.86597938 85.74662234 62.37 82.65 34.46552051 130.93 103.87 113.0952381 200.1503759 62.07671958 167.037037 81.88 88.19 93.68 41.52273973 37.26965498 37.5 84.34787234 28.91566265 37.78567901 69.80979532 18.69169317 40.57629179 56.75422139 54.56553965 111.8453355 97.61568663 56.72229569 48.87695313 99.7869102 62.77373397 75.48117155 99.58 142.88 43.14390244 61.54310345 34.03671971 26.26477541 86.6185973 72.98268072 73.23866667 73.49743142 75.409125 142.9321918 94.31473253 50.79756505 101.3399786 78.71314741 30.501526 42.89650538 70.9902439 50.20212766 29.63584481 78.44391408 73.6324193 68.07517106 26.93044444 60.3095625 123.4311594 42.17108434 31.98601748 35.11895425 51.50970771 68.59550562 47.02960526 71.64875731 39.6440818 56.22311605 140.1969441 42.5643299 47.96987265 56.08692594 53.50984375 69.27116802 105.6675357 34.75609756 140.9375359 56.71875 69.55645161 78.24276377 40.07756098 46.44972569 75.63791899 96.00383632 34.67513441 50.58958756 63.26243166 66.48577234 74.41523347 53.14282077 61.89147857 59.94700214 88.07441214 175.2968037 Lysine 76.16 104.69 163.88 210.51 79.34 48.25 153.17 93.26 72.62 81.1 503.5 52.14 68.66 154.61 135.31 192.14 79.01 181.42 179.1855204 91.84206449 165.4954143 85.16045322 233.165792 56.05195783 104.5329891 117.8730337 64.84375 50.77859995 158.1808794 56.4709126 92.19017143 100.6895804 50.3025 202.3684211 192.0938515 99.6704584 76.61616365 61.62564103 165.7667528 93.625 176.1395164 57.85519126 159.5 147.9610245 375.1212615 113.3760128 121.5978261 41.0243984 130.0540963 332.6977622 64.00939542 79.14145658 53.91060606 92.42998222 78.02197802 109.68 61.41 58.23682962 34.64219233 158.2792683 89.86184211 131.7739319 58.4137931 82.31907895 145.5393145 72.60803653 81.25628816 199.3778571 85.56848837 99.23627685 238.6584192 110.5497137 96.62532609 67.65 59.48389218 260.9253012 34.45094217 85.7483863 43.73170732 34.10279492 256.0464977 174.6336806 38.54584433 109.9360608 118.9678218 41.83907213 74.16494845 124.6516234 62.91 137.36 63.80067728 165.96 120.58 123.8906926 209.5238095 138.1803902 161.718107 228.35 323.55 110.88 57.65657534 47.53782523 109.9085366 212.1835106 74.45783133 88.97506173 83.55818713 27.57487409 148.7340426 136.3352095 139.0451823 145.3311511 128.1822148 65.18830997 77.5764974 302.7092846 199.4584773 132.4964136 377.77 385.24 46.47430894 102.3731527 88.64626683 26.9213948 100.3450417 85.82981928 204.6185556 110.2949502 167.066625 282.8004566 120.0103872 114.0376797 138.0250508 174.0119522 62.85162934 76.68575269 221.954065 80.34831846 52.0334418 41.89011738 131.7632766 89.57906083 46.83555556 91.7173125 101.6322061 67.30210843 89.3937578 68.25751634 59.21689589 92.3258427 28.86644737 91.48775585 93.40797356 106.0984609 209.0879176 47.89876289 81.19000606 84.71059849 78.30367188 78.12537746 102.3693894 76.98170732 140.110114 114.0625 70.56451613 37.25210084 31.87987805 85.703015 67.95460894 266.7359335 62.46442652 96.37457742 179.7642348 76.83375247 125.2481747 112.1761711 106.3298287 72.64320128 111.044828 365.3272451 Methionine 16.01 34.04 66.63 20.73 10.86 32.84 104.02 11.81 17.71 703.54 18.05 24.9 39.13 30.12 15.51 29.95 26.75339367 15.59087828 91.2192925 26.14682495 192.471137 9.574380857 20.21356142 29.50224719 15.625 11.78355071 34.83211193 12.96526055 19.60365714 18.14099981 58.68421053 30.31736622 35.96196944 8.360395708 11.15726496 39.78866074 17.625 31.92528736 3.944672131 41.57352941 26.71358575 241.2302778 50.67242522 36.4673913 7.702540107 13.80291116 137.4570648 15.44628268 11.69327731 20.97878788 28.4195635 10.57692308 30.57 14.24 10.50794969 63.5357629 14.58963816 30.19199567 10.36781609 10.76480263 21.62298387 17.25719178 14.10793651 43.99714286 21.76742248 20.08353222 131.0020619 21.88547631 25.69956522 12.65 16.38841927 49.53313253 15.70962963 24.45233366 22.13414634 6.768493648 81.1570165 44.09302885 9.354221636 26.07858261 20.51485149 14.86734324 16.67010309 55.40072151 12.47 31.89 11.31310978 38.99 27.62 41.76812771 19.29824561 26.56167328 34.51646091 41.3 124.01 29.26 15.50849315 14.93902439 66.74255319 11.27710843 48.12567901 18.15321637 10.4562442 36.60091185 43.62101313 59.82820591 21.14893617 23.78766101 27.93784713 28.19824219 32.31354642 150.1362577 20.75732218 138.69 103.64 11.80780488 43.06527094 8.401468788 7.61678487 15.61974705 15.03388554 88.44318519 30.06269439 43.8845 180.0057078 34.16354089 14.61143444 28.57787396 31.15537849 17.95760838 24.28602151 140.2276423 14.32566918 10.51594493 11.73990551 24.32141617 34.1604649 15.36791667 26.8970625 21.94331723 16.91746988 22.31860175 12.27843137 14.38675128 17.6741573 9.568092105 31.25712719 12.38198719 22.15242591 52.87572869 9.335257732 9.301637356 27.07644701 17.3696875 19.01050852 19.15461932 14.93902439 64.40100711 23.4375 19.32123656 17.22408964 4.684390244 21.98184202 11.6103352 57.32097187 5.656227599 34.1974307 42.56546328 13.71107367 23.71330503 17.5435336 22.55481215 15.70663812 16.87881385 64.45966514 CAR(2:0) 71.09 4.15 8.38 1225.52 7.44 7.15 25.39 5.14 2.76 6.76 66.12 220.19 23.25 6.26 54.23 12.93 34.25 70.42 140.2375566 16.63900455 40.73206682 132.3224833 21.60660836 133.5765562 85.18572312 20.39325843 135.3125 6.316955017 26.03431046 60.36049076 27.55108571 14.76593008 111.435 10.52631579 5.912515404 91.3 2.745204561 3.128205128 198.5952979 87.25 8.146452636 3.81318306 97.86764706 288.3224944 3.821663354 19.9673913 21.6006016 50.76403993 21.61787666 90.32986111 2.203081232 322.1219697 23.90430575 13.5 7.96 13.29318937 20.16500284 77.59621711 18.73985938 9.356321839 21.14967105 28.60887097 22.88175799 18.44884005 9.861428571 10.50841085 67.7326969 36.53058419 14.59031754 35.90380435 12.2375 23.79355687 148.5993976 13.36696556 135.8095829 19.31707317 8.720943739 31.7627301 5.689423077 137.5715699 4.997093673 12.18069307 109.0710402 19.6185567 23.49862064 18.31 7.37 7.761319504 86.88 5.52 16.19318182 63.4085213 7.46114418 32.25308642 11.29 97.15 9.5 56.40589041 50.96054864 8.68902439 88.42074468 7.373493976 298.9664198 29.63245614 28.4076723 56.75197568 5.472170106 18.83480556 9.62547736 21.56912268 200.2212378 235.3613281 20.92846271 135.8169037 12.53526599 37.85 22.12 35.27203252 8.195812808 141.3170135 327.7843972 9.939839034 185.0534639 138.1255556 24.79196226 82.7695 22.51986301 62.04916614 10.5019685 115.6289156 24.09960159 23.10721667 58.33924731 387.926626 3.363417982 2.867984981 76.44279382 205.7965984 88.4731465 46.83555556 76.6816875 24.68623188 11.15572289 7.161048689 30.10196078 158.1258109 16.06741573 13.29802632 34.53983918 73.42301177 49.48670583 136.5108957 8.335051546 127.8310734 110.4332232 6.72375 4.687522648 34.75738871 83.53658537 282.4266864 6.09375 15.35480859 30.83890244 41.87017527 7.683310056 17.5831202 164.2765233 4.38066261 69.12006422 9.701231372 5.50253487 4.738034623 288.3793839 19.50240899 9.518128113 34.82496195 Ornithine 38.15 41.12 66.25 82.91 48.34 35.93 66.51 52.37 39.83 29.2 238.04 18.31 18.6 36.68 51.67 52.71 30.38 70.04 120.9502262 20.04541493 16.2585981 142.2324587 21.65855087 41.43780091 69.88089888 23.59375 18.46494544 26.57295137 81.72605714 34.73509267 114.57 109.0789474 81.39143545 28.52156197 17.34470154 25.44273504 25.5204238 29.25 17.47058824 52.0454343 161.4493722 35.95194415 40.89130435 52.91115944 81.16900859 12.97487745 39.99439776 37.07878788 24.70111594 40.76 56.46 75.07486948 31.98761821 61.29520703 53.06496711 50.56787453 11.75862069 62.37399194 68.26178082 11.53052503 74.97214286 19.94453488 18.63961814 110.1965636 56.95835502 33.63619565 19.78749883 169.3271084 27.6985575 17.84359484 19.98780488 42.56341198 114.9940473 76.33309295 23.70811346 34.04270065 83.79950495 46.31243204 20.29896907 37.19318101 22.17 62.52 37.75421521 28.05 66.82 13.87987013 24.67418546 53.42179233 194.0843621 110.46 113.2 223.94 18.13493151 33.21309389 113.9090426 23.13253012 26.55209877 51.25614035 19.60273556 38.46153846 60.24367956 55.99045281 30.44327601 77.74623116 23.56119792 94.76407915 136.6847433 60.25014943 99.81 82.5 24.14039409 32.63647491 9.586643026 17.9863754 23.64420181 91.44125926 37.96879259 98.60125 74.75981735 60.15119164 43.72015149 15.80903666 59.92828685 53.47670143 47.91209677 176.1609756 75.49004804 35.35312454 56.12634502 33.54606805 39.07841667 70.01650564 29.00224719 23.63267974 31.39325843 15.08190789 35.68165205 22.48308201 48.19124232 122.0209124 15.22536082 105.2413827 25.62592306 13.16734375 22.65635946 57.21015441 12.95731707 84.81074813 69.375 38.47446237 22.6984127 98.13322328 28.17213687 157.1930946 24.83821685 79.27586207 9.372212098 34.14833443 89.74372347 23.17795316 33.02668921 32.06771949 57.10876868 97.94520548 Phenylalanine 32.68 78.33 126.5 104.43 48.72 32.92 80.04 79.39 51.14 44.33 109 36.13 45.27 92.29 105.76 138.18 44.92 49.56 133.2692308 42.84216132 84.03128071 58.03617687 103.5261419 37.92570281 97.74700772 72.6 76.09375 42.51796646 58.17321785 46.38682106 92.72 47.25097626 73.53 79.07894737 70.06959745 48.98268251 20.58903421 40.77094017 76.90927718 55.625 51.30063417 31.42588798 109.1911765 86.35857461 227.6398397 125.6902614 106.0543478 47.72225936 86.9583403 172.9430133 36.82393791 58.29691877 71.44731385 28.2967033 65.86 37.64 44.31063123 111.2266558 184.0456608 38.08799342 100.98702 30.59770115 44.07236842 44.24395161 50.10977169 57.92393162 78.765 51.79145349 61.82577566 254.0206186 71.26808954 59.83967391 40.975 44.06663849 135.4921687 69.03968811 77.8178997 55.26829268 67.68493648 255.5279225 81.8644765 51.12565963 62.61983009 66.39851485 90.25661472 39.12371134 71.42958195 51.69 66.48 37.09647627 93.99 94.04 93.94615801 97.18045113 81.32647156 93.93004115 92.88 155.78 68.92 46.77561644 43.10096154 95.88414634 137.1638298 41.92771084 76.33728395 66.87324561 15.91569914 64.15440729 199.0306442 77.00111686 106.9648118 79.00461507 89.45755091 53.76464844 92.25266362 124.5349884 74.4028691 220.73 180.52 126.1013008 155.4224138 51.37821297 67.63179669 41.33710836 131.8881777 160.6111111 136.1605801 60.27175 168.3627854 121.1783715 39.83898922 79.75456314 67.07569721 54.00486638 75.49784946 168.4922764 57.55181881 43.56605757 154.2196678 59.46719889 145.6120536 38.34661111 62.6484375 78.82270531 64.48253012 49.05318352 63.76862745 65.51109958 62.41573034 54.81381579 87.06323099 40.83883495 55.31629159 212.0113352 36.45195876 36.94078836 64.20986005 86.8484375 53.77630149 113.9129017 35.21341463 112.9430938 44.21875 44.0188172 53.67507003 57.77414634 68.03903481 40.12395251 176.3586957 38.36397849 70.51453685 67.81836809 42.81476779 63.93421468 40.72148676 37.05433424 46.72724839 47.20991544 138.7975647 Proline 77.07 108.47 122.88 1416.93 49.75 78.15 119.78 82.86 63.45 85.29 515.89 96.29 81.11 118.43 299.2 70.61 162.49 263.9253394 78.08540719 147.8676711 82.71682472 388.3887269 101.5999833 78.83288953 78.44606742 328.59375 94.63284536 111.4986676 83.98607665 126.2316571 97.31451063 100.89 180.9210526 292.8582098 126.486927 99.32649229 101.1452991 172.0308568 190.875 974.051526 665.8235294 923.1155902 470.8835158 140.4107425 95.5326087 356.575205 316.1104606 76.73713235 80.86590909 201.3273751 144.2 79.38 65.57973422 147.5943214 221.0148327 120.9777961 371.3764197 49.26480263 216.7288306 119.9055251 128.5992674 116.3142857 53.61434109 590.1745704 74.63508589 97.25521739 109.1347328 131.8343373 106.5223132 89.54841112 177.0731707 104.9116515 772.8066699 184.1160524 88.86510554 106.0320814 168.240099 160.5146792 98.65979381 260.5078871 102.85 191.08 57.88102681 72.92 262.98 70.29897186 86.29072682 123.5565476 81.14197531 164.33 396.7 193.78 132.9268293 537.7505319 433.5140741 84.75950292 61.904667 127.7604863 197.467167 201.2277389 119.4372613 81.46965766 233.5208939 113.1689453 139.6347032 410.1988699 121.8481769 458.08 673.81 102.4856911 196.2524631 92.97730496 59.79680943 281.7118889 266.1719727 243.309 220.1431507 335.7954873 120.4301823 149.0711085 239.438247 196.0040323 432.8432927 96.9162663 65.14423029 67.90468073 239.3387713 176.0861374 98.79375 133.8170625 148.4061192 72.69608434 106.2810458 104.9462125 71.19101124 105.0467836 68.53538525 124.623589 554.8138359 121.4528078 236.3387017 89.0896875 86.06812417 185.837863 97.56097561 245.0547958 300.78125 145.8333333 82.91596639 146.647439 317.0357334 110.9811453 298.7372123 123.4533154 233.729547 396.36647 83.81863905 292.8134627 143.0374236 109.9547092 123.4279979 99.49616588 219.8325723 Propylene glycol 309.6 24.52 98.75 449.05 18.94 10.51 45.95 28.82 19.22 40.95 193.49 19.4 18.33 30.71 47.83 41.04 30.05 34.87 23.39366516 31.7058197 40.73206682 19.67120942 44.27366375 9.388470549 147.9921461 16.85842697 301.25 21.13750333 26.3934044 21.46470913 22.2528 110.6741617 21.945 23.15789474 24.40485082 31.31171477 83.229611 39.41538462 86.88544284 32.75 100.6196988 19.32889344 124.3970588 87.7403118 64.80625618 49.11545126 28.45652174 22.60528075 41.56209916 42.01209992 42.50816993 20.67507003 27.56515152 31.60680427 146.8406593 26.75 11.1 191.5485287 29.28726602 283.6587171 42.68523526 49.81609195 22.66940789 127.4092742 35.40920091 66.06312576 29.45785714 37.42281008 17.32696897 30.36151203 17.9573139 31.49456522 14.9875 29.49915469 69.80361446 21.22178038 1954.36929 15.02439024 78.61865699 162.4436768 112.9982639 33.54617414 29.04560698 167.6905941 210.5110547 61.57731959 90.72646247 52.32 35.84 40.77981434 18.47 33.14 53.07765152 43.83458647 40.43940146 35.08230453 16.43 233.49 25.92 16.00876712 47.66459276 310.5182927 66.0856383 37.59036145 277.3928395 61.26710526 55.14974818 64.70273556 58.630394 55.67346939 48.398527 64.33761165 165.5105792 54.39127604 35.99695586 85.77148443 993.46 2288.98 37.84552846 60.79802956 90.58506732 257.7887707 104.9205231 160.4525602 708.1879259 37.77358029 74.9925 54.69109589 64.67713082 38.92577456 116.7436553 122.7888446 72.35859848 130.9333333 350.6786585 23.54392588 90.54638298 41.42658799 36.98669041 80.64497222 186.44175 52.83719807 73.06385542 88.08089888 46.20915033 103.533228 70.20224719 34.38026316 129.0248538 25.08981615 17.74785 297.0446586 42.78659794 23.12121286 394.5425135 83.34648438 18.61988163 17.12499079 38.1097561 45.50820631 32.34375 86.18951613 44.99626517 64.41036585 38.46822353 21.51326816 52.74936061 16.84572133 33.77349561 33.32342079 30.13849213 23.5822923 95.65707739 27.52224101 46.20369379 28.17365921 26.11872146 Pyruvic acid 49.6 130.43 67.63 626.07 70.86 20.68 54.09 55.36 22.49 57.31 138.93 40.13 39.12 29.82 68.42 156.63 32.31 18.06 108.6312217 37.86356154 142.3910907 95.42369292 57.39669582 21.28673025 62.6620404 56.1494382 268.75 44.70460474 44.34810127 54.74221119 58.4136 25.03176719 335.73 46.97368421 86.67495986 50.37775891 14.59949698 100.9367521 50.92484567 77.375 69.575109 31.68886612 295.5441176 131.7256125 43.53973716 71.90388829 34.31521739 105.8262032 142.4767163 113.7997658 40.65461601 90.15686275 51.83712121 84.72748371 27.1978022 31.59 23.89 45.07024205 40.88044153 125.1510493 87.27960526 122.1065441 32.87356322 37.99342105 44.07762097 34.89787671 47.74993895 102.9128571 59.40468992 46.9928401 175.2742268 48.96173868 45.60413043 40.8375 113.9905607 53.19096386 84.61151397 70.21785005 65.46341463 45.42700544 63.5254602 78.54564637 33.86873351 65.89917281 8.425742574 65.91627401 56.58762887 109.867723 30.69 66.84 32.3607559 98.37 55.1 43.05330087 47.69423559 56.25702712 48.09670782 67.16 51.02 65.58 33.14315068 118.7811793 106.8597561 309.8010638 69.39759036 164.0358025 49.3874269 45.71136846 18.91732523 73.17073171 71.32297695 70.4964539 109.4478911 59.96760116 29.4514974 41.68949772 91.70172197 41.91900777 82.5 175.39 28.30845528 83.29926108 29.5128519 61.59089835 24.29738431 43.46159639 139.8387407 36.40709418 115.26625 95.90091324 90.08078943 46.68809911 55.63564824 77.24701195 60.60692829 60.71505376 72.63353659 36.87302677 124.2793492 74.97530564 17.63970843 59.71937389 70.98513889 103.0775625 51.97101449 123.8162651 17.30586767 72.21830065 95.44068037 28.42696629 84.00460526 50.09703947 46.16091717 84.85285947 49.44389053 29.56164948 27.77203153 53.76608763 98.19476563 108.2036478 42.11479216 83.23170732 90.87850897 79.375 106.686828 85.9869281 45.67280488 96.30140312 64.19832402 127.1259591 52.25862455 55.95943205 177.2910122 43.97891555 49.91585203 39.31288187 65.11359459 54.9732334 46.06774007 107.4885845 Tyrosine 30.47 43.32 34.75 92.33 29.87 18.01 80.31 22 25.13 48.25 138.51 19.64 30.23 47.41 54.86 78.44 28.11 30.24 74.16289593 29.74058294 97.38044546 20.89302367 43.61088435 24.07538487 36.09564539 55.60561798 38.4375 34.37881288 75.05063291 33.85373587 71.12948571 39.65706936 26.3625 53.02631579 51.57726203 51.9278438 19.34121395 17.62222222 47.32878596 36.5 33.24633373 72.63235294 22.91380846 52.85170407 47.70002038 43.76086957 33.89381518 226.5118397 22.98406863 23.55602241 26.95530303 59.62796267 21.84065934 29.94 23.89 33.42287613 29.7312302 71.05762904 30.21217105 54.58355868 34.51724138 27.35526316 26.61290323 41.28942922 38.25421245 50.82428571 37.3155814 34.39140811 149.9931271 39.28162415 26.95934783 22.4125 31.68427726 120.5560241 37.48262508 49.73075968 30.18292683 27.98511797 20.09478843 79.96800214 32.41721636 34.355019 45.79207921 52.23305545 37.42268041 103.6429228 42.63 45.82 25.52027091 37.21 36.64 77.49594156 51.27819549 38.35028108 67.33539095 52.01 95.29 63.01 31.0169863 29.02976527 89.32926829 92.36223404 36 45.06197531 42.71345029 12.5845063 56.75197568 93.02689181 133.3670423 63.31123841 55.58671044 27.65564665 33.96321615 43.36377473 92.42492167 35.31440526 142.5 158.64 38.75382114 71.67610837 26.17380661 34.9321513 37.07717735 47.56174699 155.4715556 73.10700681 65.410125 116.5824201 90.3727855 28.99456522 51.0753492 60.11155378 41.32890753 32.33736559 98.59756098 51.57240906 18.02733417 28.68272369 29.93405068 80.36310807 49.32369444 36.9208125 55.002657 31.26054217 35.80524345 45.94509804 37.76522211 33.86516854 36.65065789 47.81341374 38.77517042 61.53451641 89.48200241 26.11649485 24.58289873 55.99022435 36.14015625 37.89080807 88.92310031 32.31707317 42.88803686 43.125 33.09811828 32.31185808 31.87987805 39.7766665 98.81713555 19.79679659 12.43542934 69.25023383 34.79508319 55.4183869 41.61787169 33.02668921 32.59127409 35.91507008 175.7990868 Valine 49.73 72.96 184.13 282.09 102.43 68.85 137.16 158.9 74 83.8 252.24 58.81 67.02 112.42 141.32 208.84 85.63 155.82 168.6085973 152.3713566 83.86013757 92.49133872 249.0724976 97.41700134 142.505608 173.8865169 61.875 97.66984296 143.637575 79.37620623 148.2195429 75.37655737 73.53 223.8157895 104.6641025 49.137691 142.6258551 81.22905983 74.8212425 109.375 92.91359493 76.13217213 101.1029412 65.74766147 296.8504045 221.9395607 130.923913 85.06283422 114.870894 251.5287536 121.5931373 94.39355742 94.89242424 110.0926081 41.8956044 168.28 83.48 75.8344803 60.65701876 178.6043108 87.02138158 159.1400757 117.7126437 82.95230263 63.20564516 144.8325799 145.2846154 141.9792857 122.7768411 74.1646778 187.0075601 126.2623634 100.7826087 101.6125 63.36855452 241.2644578 70.27992203 106.4006951 88.53658537 96.71136116 111.364021 135.9139957 101.7674802 76.20567852 114.0222772 124.7277999 80.17525773 104.5766429 98.36 131.43 72.74592687 153.51 163.42 152.5500541 251.7042607 126.2425595 221.0185185 165.19 124.35 165.68 71.41410959 79.99031391 75.15243902 130.5946809 51.03614458 62.55061728 138.952193 39.32658217 74.02431611 90.68167605 107.1922023 180.9860884 138.1656373 137.7138323 81.46158854 172.1156773 99.94619855 123.4656306 147.35 187.37 98.24699187 102.5221675 64.08812729 52.52955083 134.7400402 124.2345633 126.4544815 171.103582 138.875 156.260274 175.0516475 107.6451772 120.7972545 135.7091633 82.92189753 65.07069892 117.002439 121.4567605 69.51449312 141.9461302 109.3127386 124.3539226 104.06275 117.1108125 210.6269726 80.41927711 66.83645443 105.2248366 85.42133572 136.4494382 77.19342105 142.7266082 71.25073332 106.875739 252.4307625 92.35237113 86.37234688 89.54567832 93.99242188 123.9589322 196.1128575 51.06707317 161.3472769 100.625 117.4395161 131.6507937 130.772561 111.6101859 121.7377793 181.2819693 76.85091846 112.3427992 109.3424745 112.0168849 147.1273014 87.33350305 69.27549445 129.5797645 127.1621916 230.7153729 NMR_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name KEGG ID 2-Hydroxybutyric acid C05984 Ketoleucine C00233 3-Hydroxybutyric acid C01089 Alanine C00041 Betaine C00719 Carnitine C00318 Choline C00114 Citric acid C00158 Creatine C00300 Creatinine C00791 Glucose C00221 Glutamine C00064 Glycine C00037 Histidine C00135 Isoleucine C00407 Lactic acid C00186 Leucine C00123 Lysine C00047 Methionine C00073 CAR(2:0) C02571 Ornithine C00077 Phenylalanine C00079 Proline C00148 Propylene glycol C00583 Pyruvic acid C00022 Tyrosine C00082 Valine C00183 METABOLITES_END #END