#METABOLOMICS WORKBENCH araskind_20200318_123441 DATATRACK_ID:1944 STUDY_ID:ST001383 ANALYSIS_ID:AN002304 PROJECT_ID:PR000947 VERSION 1 CREATED_ON May 19, 2020, 11:06 am #PROJECT PR:PROJECT_TITLE Health impacts of endocrine disrupting chemicals PR:PROJECT_TYPE Observational study PR:PROJECT_SUMMARY Investigating exposures and health impacts of endocrine disrupting chemicals PR:PROJECT_SUMMARY among inner-city children. PR:INSTITUTE University of Michigan PR:DEPARTMENT Nutritional Sciences PR:LABORATORY Meeker Lab PR:LAST_NAME Meeker PR:FIRST_NAME John PR:ADDRESS Ann Arbor, MI PR:EMAIL meekerj@umich.edu PR:PHONE 734-764-7184 #STUDY ST:STUDY_TITLE Investigating exposures and health impacts of endocrine disrupting chemicals ST:STUDY_TITLE among inner-city children. ST:STUDY_TYPE Observational study ST:STUDY_SUMMARY Our CHEAR project will conduct untargeted metabolomics analyses among children ST:STUDY_SUMMARY with and without asthma to gain insight into potential mechanisms related to ST:STUDY_SUMMARY asthma development. Metabolomics analysis will be conducted in a subset of ST:STUDY_SUMMARY participants from DISCOVER, a panel study enriched with low-income African ST:STUDY_SUMMARY American children in Baltimore, MD enrolled from 2009 to 2013. We will conduct ST:STUDY_SUMMARY untargeted metabolomics in serum collected from 15 children with non-atopic ST:STUDY_SUMMARY asthma and 22 non-atopic children without asthma. For each child, we will ST:STUDY_SUMMARY conduct analyses in two serum samples collected 3-9 months apart (total = 74 ST:STUDY_SUMMARY samples). We will use these pilot data to explore differences in metabolomic ST:STUDY_SUMMARY profiles among non-atopic children with asthma compared to non-asthmatic ST:STUDY_SUMMARY controls, and leverage repeated sample measures to assess differences in ST:STUDY_SUMMARY metabolomic profiles among asthmatic children by symptom frequency or severity. ST:STUDY_SUMMARY Finally, these data will be used to explore differences in metabolomic profiles ST:STUDY_SUMMARY by exposure status after urinary organophosphate flame retardant biomarkers have ST:STUDY_SUMMARY been quantified by CHEAR. Together, these analyses will provide pilot data for ST:STUDY_SUMMARY future work in our Center to assess potential mechanisms related to asthma ST:STUDY_SUMMARY development and severity as well as effects of organophoshate flame retardant ST:STUDY_SUMMARY exposures. ST:INSTITUTE University of Michigan ST:DEPARTMENT Biomedical Research Core Facilities ST:LABORATORY Metabolomics core ST:LAST_NAME Kachman ST:FIRST_NAME Maureen ST:ADDRESS Ann Arbor, MI ST:EMAIL mkachman@med.umich.edu ST:PHONE 734-232-0842 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS SU0036817 C-1NXX5-S-00 Gender:Male | Condition:asthmatic Age (years)=9.4; Family ID=1001; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041078-P;20190723-EX00961-A003-IN0029-S00041078-N SUBJECT_SAMPLE_FACTORS SU0036818 C-1NXY3-S-00 Gender:Male | Condition:asthmatic Age (years)=9.4; Family ID=1001; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041079-P;20190723-EX00961-A003-IN0029-S00041079-N SUBJECT_SAMPLE_FACTORS SU0036819 C-1NY02-S-00 Gender:Male | Condition:control Age (years)=9.3; 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Family ID=1200; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041142-P;20190723-EX00961-A003-IN0029-S00041142-N SUBJECT_SAMPLE_FACTORS SU0036880 C-1NZX3-S-00 Gender:Male | Condition:control Age (years)=7.7; Family ID=1200; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041143-P;20190723-EX00961-A003-IN0029-S00041143-N SUBJECT_SAMPLE_FACTORS SU0036881 C-1NZY1-S-00 Gender:Male | Condition:asthmatic Age (years)=12.8; Family ID=1205; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041144-P;20190723-EX00961-A003-IN0029-S00041144-N SUBJECT_SAMPLE_FACTORS SU0036882 C-1P009-S-00 Gender:Male | Condition:asthmatic Age (years)=12.8; Family ID=1205; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041145-P;20190723-EX00961-A003-IN0029-S00041145-N SUBJECT_SAMPLE_FACTORS SU0036883 C-1P017-S-00 Gender:Female | Condition:control Age (years)=8.4; Family ID=1217; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041146-P;20190723-EX00961-A003-IN0029-S00041146-N SUBJECT_SAMPLE_FACTORS SU0036884 C-1P025-S-00 Gender:Female | Condition:control Age (years)=8.4; Family ID=1217; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041147-P;20190723-EX00961-A003-IN0029-S00041147-N SUBJECT_SAMPLE_FACTORS SU0036885 C-1P033-S-00 Gender:Male | Condition:control Age (years)=7.9; Family ID=1218; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041148-P;20190723-EX00961-A003-IN0029-S00041148-N SUBJECT_SAMPLE_FACTORS SU0036886 C-1P041-S-00 Gender:Male | Condition:control Age (years)=7.9; Family ID=1218; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041149-P;20190723-EX00961-A003-IN0029-S00041149-N SUBJECT_SAMPLE_FACTORS SU0036887 C-1P058-S-00 Gender:Male | Condition:control Age (years)=7.8; Family ID=1220; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041150-P;20190723-EX00961-A003-IN0029-S00041150-N SUBJECT_SAMPLE_FACTORS SU0036888 C-1P066-S-00 Gender:Male | Condition:control Age (years)=7.8; Family ID=1220; Sample type=Sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-S00041151-P;20190723-EX00961-A003-IN0029-S00041151-N SUBJECT_SAMPLE_FACTORS - R00CHRPL1-1 Gender:CHEAR | Condition:CHEAR Age (years)=CHEAR; Family ID=CHEAR; Sample type=CHEAR reference; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-R00CHRPL1-1-P;20190723-EX00961-A003-IN0029-R00CHRPL1-1-N SUBJECT_SAMPLE_FACTORS - R00CHRPL1-2 Gender:CHEAR | Condition:CHEAR Age (years)=CHEAR; Family ID=CHEAR; Sample type=CHEAR reference; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-R00CHRPL1-2-P;20190723-EX00961-A003-IN0029-R00CHRPL1-2-N SUBJECT_SAMPLE_FACTORS - R00CHRPL1-3 Gender:CHEAR | Condition:CHEAR Age (years)=CHEAR; Family ID=CHEAR; Sample type=CHEAR reference; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-R00CHRPL1-3-P;20190723-EX00961-A003-IN0029-R00CHRPL1-3-N SUBJECT_SAMPLE_FACTORS - R00CHRPL1-4 Gender:CHEAR | Condition:CHEAR Age (years)=CHEAR; Family ID=CHEAR; Sample type=CHEAR reference; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-R00CHRPL1-4-P;20190723-EX00961-A003-IN0029-R00CHRPL1-4-N SUBJECT_SAMPLE_FACTORS - Master pool-01 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-01-P;20190723-EX00961-A003-IN0029-CS00000MP-01-N SUBJECT_SAMPLE_FACTORS - Master pool-02 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-02-P;20190723-EX00961-A003-IN0029-CS00000MP-02-N SUBJECT_SAMPLE_FACTORS - Master pool-03 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-03-P;20190723-EX00961-A003-IN0029-CS00000MP-03-N SUBJECT_SAMPLE_FACTORS - Master pool-04 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-04-P;20190723-EX00961-A003-IN0029-CS00000MP-04-N SUBJECT_SAMPLE_FACTORS - Master pool-05 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-05-P;20190723-EX00961-A003-IN0029-CS00000MP-05-N SUBJECT_SAMPLE_FACTORS - Master pool-06 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-06-P;20190723-EX00961-A003-IN0029-CS00000MP-06-N SUBJECT_SAMPLE_FACTORS - Master pool-07 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-07-P;20190723-EX00961-A003-IN0029-CS00000MP-07-N SUBJECT_SAMPLE_FACTORS - Master pool-08 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-08-P;20190723-EX00961-A003-IN0029-CS00000MP-08-N SUBJECT_SAMPLE_FACTORS - Master pool-09 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-09-P;20190723-EX00961-A003-IN0029-CS00000MP-09-N SUBJECT_SAMPLE_FACTORS - Master pool-10 Gender:POOL | Condition:POOL Age (years)=POOL; Family ID=POOL; Sample type=Pooled sample; RAW_FILE_NAME=20190723-EX00961-A003-IN0029-CS00000MP-10-P;20190723-EX00961-A003-IN0029-CS00000MP-10-N #COLLECTION CO:COLLECTION_SUMMARY Standard blood serum collection protocol CO:SAMPLE_TYPE Blood (serum) CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY This is observational study #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Standard untargeted metabolomics sample preparation (see enclosed protocol) #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY RP-LCMS-Positive CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1290 Infinity II CH:COLUMN_NAME Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Agilent 6540 QTOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Untargeted recursive search (Agilent Qual/MPP/In-house software) MS:MS_RESULTS_FILE ST001383_AN002304_Results.txt UNITS:Peak area normalized Has m/z:Yes Has RT:Yes RT units:Minutes #END