#METABOLOMICS WORKBENCH jkempa_20200923_094913 DATATRACK_ID:2178 STUDY_ID:ST001614 ANALYSIS_ID:AN002649 PROJECT_ID:PR001037
VERSION             	1
CREATED_ON             	December 1, 2020, 2:09 pm
#PROJECT
PR:PROJECT_TITLE                 	NMR and MS Metabolomics Reveal a Distinct Metabolic State of Ricin-induced
PR:PROJECT_TITLE                 	Hypoglycemia
PR:PROJECT_TYPE                  	Targeted NMR and Untargeted MS
PR:PROJECT_SUMMARY               	Ricin toxin is a ribosome inactivating protein. Due to its toxic and chemical
PR:PROJECT_SUMMARY               	properties, ricin is a potential agent of bioterrorism but has also been studied
PR:PROJECT_SUMMARY               	for therapeutic use in immunotoxins. Previous research by our group has
PR:PROJECT_SUMMARY               	demonstrated lethal hypoglycemia associated with ricin toxicity. Research
PR:PROJECT_SUMMARY               	efforts have focused on better understanding this ricin-induced metabolic state
PR:PROJECT_SUMMARY               	of hypoglycemia to aid in better understanding the systemic effects of
PR:PROJECT_SUMMARY               	hypoglycemia, and the use of ricin in immunotherapy. Here, we have used a mouse
PR:PROJECT_SUMMARY               	model to characterize liver metabolome changes associated with hypoglycemia
PR:PROJECT_SUMMARY               	induced by two conditions. Mice were challenged with intraperitoneal injections
PR:PROJECT_SUMMARY               	of ricin at high and low doses for 2 hrs, 8 hrs, and overnight. To understand
PR:PROJECT_SUMMARY               	how ricin-induced hypoglycemia differs from that of fasting, another group of
PR:PROJECT_SUMMARY               	mice had food withheld for 8-hours and overnight. 1H NMR-based metabolomics was
PR:PROJECT_SUMMARY               	performed on polar molecules extracted from mouse livers, with metabolites
PR:PROJECT_SUMMARY               	annotated using Chenomx software. MetaboAnalyst was employed for multivariate
PR:PROJECT_SUMMARY               	statistical analysis. In this study, similar decreases in blood glucose in mice
PR:PROJECT_SUMMARY               	were observed following injection of a lethal dose of ricin and with overnight
PR:PROJECT_SUMMARY               	fasting. NMR analyses identified 59 polar metabolites present in mice livers
PR:PROJECT_SUMMARY               	from all treatments. Multivariate statistical analyses were used to evaluate
PR:PROJECT_SUMMARY               	global metabolic state differences. Results from these analyses indicated that
PR:PROJECT_SUMMARY               	the profiled liver metabolomes for mice subjected to the two conditions differ
PR:PROJECT_SUMMARY               	significantly at both 8 hours and overnight. Additionally, ricin treatment with
PR:PROJECT_SUMMARY               	a lethal dose reveal a progression of metabolic changes over time, from 2 to 22
PR:PROJECT_SUMMARY               	hours. Additionally, mass spectrometry supported these findings, and NMR
PR:PROJECT_SUMMARY               	analyses revealed key metabolites that contribute to these differences. While
PR:PROJECT_SUMMARY               	both ricin and fasting induce hypoglycemia, the metabolic states resulting from
PR:PROJECT_SUMMARY               	these two conditions are different. Further analyses may give insights into
PR:PROJECT_SUMMARY               	mechanisms of ricin toxicity, specific metabolic pathways that are altered, and
PR:PROJECT_SUMMARY               	potential treatments for hypoglycemia. We propose to extend these studies to
PR:PROJECT_SUMMARY               	insulin-induced hypoglycemia.
PR:INSTITUTE                     	Montana State University
PR:DEPARTMENT                    	Chemistry & Biochemistry
PR:LABORATORY                    	Copié
PR:LAST_NAME                     	Kempa
PR:FIRST_NAME                    	Jake
PR:ADDRESS                       	103 Chemistry and Biochemistry Building, Bozeman, Montana, 59717, USA
PR:EMAIL                         	jkempa97@gmail.com
PR:PHONE                         	4067997200
#STUDY
ST:STUDY_TITLE                   	NMR metabolomics analysis of ricin-induced and fasting hypoglycemia (part-I)
ST:STUDY_TYPE                    	Targeted NMR
ST:STUDY_SUMMARY                 	Mice were subject to ricin exposure or fasting conditions for 2 hours, 8 hours,
ST:STUDY_SUMMARY                 	or an overnight time period. Following treatment, livers were removed and
ST:STUDY_SUMMARY                 	metabolites were extracted and analyzed by NMR.
ST:INSTITUTE                     	Montana State Universty
ST:DEPARTMENT                    	Chemistry & Biochemistry
ST:LABORATORY                    	Copié
ST:LAST_NAME                     	Kempa
ST:FIRST_NAME                    	Jake
ST:ADDRESS                       	103 Chemistry and Biochemistry Building
ST:EMAIL                         	jkempa97@gmail.com
ST:PHONE                         	4067997200
ST:NUM_GROUPS                    	9
ST:TOTAL_SUBJECTS                	107
ST:NUM_MALES                     	54
ST:NUM_FEMALES                   	53
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
SU:GENOTYPE_STRAIN               	BALB/c
SU:AGE_OR_AGE_RANGE              	70-74
SU:GENDER                        	Male and female
SU:ANIMAL_ANIMAL_SUPPLIER        	Montana State University Animal Resource Center
SU:ANIMAL_FEED                   	PicoLab Rodent Diet 20 5053
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	1--2	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--2
SUBJECT_SAMPLE_FACTORS           	-	1--3	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--3
SUBJECT_SAMPLE_FACTORS           	-	1--4	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--4
SUBJECT_SAMPLE_FACTORS           	-	1--5	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--5
SUBJECT_SAMPLE_FACTORS           	-	1--6	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--6
SUBJECT_SAMPLE_FACTORS           	-	1--7	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--7
SUBJECT_SAMPLE_FACTORS           	-	1--8	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--8
SUBJECT_SAMPLE_FACTORS           	-	1--9	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--9
SUBJECT_SAMPLE_FACTORS           	-	1--10	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--10
SUBJECT_SAMPLE_FACTORS           	-	1--11	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--11
SUBJECT_SAMPLE_FACTORS           	-	1--12	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--12
SUBJECT_SAMPLE_FACTORS           	-	1--13	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--13
SUBJECT_SAMPLE_FACTORS           	-	1--14	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--14
SUBJECT_SAMPLE_FACTORS           	-	1--15	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--15
SUBJECT_SAMPLE_FACTORS           	-	1--16	Treatment:Control | Timepoint:Overnight	RAW_FILE_NAME=1--16
SUBJECT_SAMPLE_FACTORS           	-	7--1	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--1
SUBJECT_SAMPLE_FACTORS           	-	7--2	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--2
SUBJECT_SAMPLE_FACTORS           	-	7--3	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--3
SUBJECT_SAMPLE_FACTORS           	-	7--4	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--4
SUBJECT_SAMPLE_FACTORS           	-	7--5	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--5
SUBJECT_SAMPLE_FACTORS           	-	7--6	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--6
SUBJECT_SAMPLE_FACTORS           	-	7--7	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--7
SUBJECT_SAMPLE_FACTORS           	-	7--8	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--8
SUBJECT_SAMPLE_FACTORS           	-	7--9	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--9
SUBJECT_SAMPLE_FACTORS           	-	7--10	Treatment:Fast | Timepoint:8h	RAW_FILE_NAME=7--10
SUBJECT_SAMPLE_FACTORS           	-	2--1	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--1
SUBJECT_SAMPLE_FACTORS           	-	2--2	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--2
SUBJECT_SAMPLE_FACTORS           	-	2--3	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--3
SUBJECT_SAMPLE_FACTORS           	-	2--4	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--4
SUBJECT_SAMPLE_FACTORS           	-	2--5	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--5
SUBJECT_SAMPLE_FACTORS           	-	2--6	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--6
SUBJECT_SAMPLE_FACTORS           	-	2--7	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--7
SUBJECT_SAMPLE_FACTORS           	-	2--8	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--8
SUBJECT_SAMPLE_FACTORS           	-	2--9	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--9
SUBJECT_SAMPLE_FACTORS           	-	2--10	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--10
SUBJECT_SAMPLE_FACTORS           	-	2--11	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--11
SUBJECT_SAMPLE_FACTORS           	-	2--12	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--12
SUBJECT_SAMPLE_FACTORS           	-	2--13	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--13
SUBJECT_SAMPLE_FACTORS           	-	2--14	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--14
SUBJECT_SAMPLE_FACTORS           	-	2--15	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--15
SUBJECT_SAMPLE_FACTORS           	-	2--16	Treatment:Fast | Timepoint:Overnight	RAW_FILE_NAME=2--16
SUBJECT_SAMPLE_FACTORS           	-	3--1	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--1
SUBJECT_SAMPLE_FACTORS           	-	3--2	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--2
SUBJECT_SAMPLE_FACTORS           	-	3--3	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--3
SUBJECT_SAMPLE_FACTORS           	-	3--4	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--4
SUBJECT_SAMPLE_FACTORS           	-	3--5	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--5
SUBJECT_SAMPLE_FACTORS           	-	3--6	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--6
SUBJECT_SAMPLE_FACTORS           	-	3--7	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--7
SUBJECT_SAMPLE_FACTORS           	-	3--8	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--8
SUBJECT_SAMPLE_FACTORS           	-	3--9	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--9
SUBJECT_SAMPLE_FACTORS           	-	3--10	Treatment:Low Dose Ricin | Timepoint:2h	RAW_FILE_NAME=3--10
SUBJECT_SAMPLE_FACTORS           	-	8--1	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--1
SUBJECT_SAMPLE_FACTORS           	-	8--2	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--2
SUBJECT_SAMPLE_FACTORS           	-	8--3	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--3
SUBJECT_SAMPLE_FACTORS           	-	8--4	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--4
SUBJECT_SAMPLE_FACTORS           	-	8--5	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--5
SUBJECT_SAMPLE_FACTORS           	-	8--6	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--6
SUBJECT_SAMPLE_FACTORS           	-	8--7	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--7
SUBJECT_SAMPLE_FACTORS           	-	8--8	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--8
SUBJECT_SAMPLE_FACTORS           	-	8--9	Treatment:Low Dose Ricin | Timepoint:8h	RAW_FILE_NAME=8--9
SUBJECT_SAMPLE_FACTORS           	-	4--1	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--1
SUBJECT_SAMPLE_FACTORS           	-	4--2	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--2
SUBJECT_SAMPLE_FACTORS           	-	4--3	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--3
SUBJECT_SAMPLE_FACTORS           	-	4--4	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--4
SUBJECT_SAMPLE_FACTORS           	-	4--5	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--5
SUBJECT_SAMPLE_FACTORS           	-	4--6	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--6
SUBJECT_SAMPLE_FACTORS           	-	4--7	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--7
SUBJECT_SAMPLE_FACTORS           	-	4--8	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--8
SUBJECT_SAMPLE_FACTORS           	-	4--9	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--9
SUBJECT_SAMPLE_FACTORS           	-	4--10	Treatment:Low Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=4--10
SUBJECT_SAMPLE_FACTORS           	-	5--1	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--1
SUBJECT_SAMPLE_FACTORS           	-	5--2	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--2
SUBJECT_SAMPLE_FACTORS           	-	5--3	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--3
SUBJECT_SAMPLE_FACTORS           	-	5--4	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--4
SUBJECT_SAMPLE_FACTORS           	-	5--5	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--5
SUBJECT_SAMPLE_FACTORS           	-	5--6	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--6
SUBJECT_SAMPLE_FACTORS           	-	5--7	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--7
SUBJECT_SAMPLE_FACTORS           	-	5--8	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--8
SUBJECT_SAMPLE_FACTORS           	-	5--9	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--9
SUBJECT_SAMPLE_FACTORS           	-	5--10	Treatment:High Dose Ricin | Timepoint:2h	RAW_FILE_NAME=5--10
SUBJECT_SAMPLE_FACTORS           	-	9--1	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--1
SUBJECT_SAMPLE_FACTORS           	-	9--2	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--2
SUBJECT_SAMPLE_FACTORS           	-	9--3	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--3
SUBJECT_SAMPLE_FACTORS           	-	9--4	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--4
SUBJECT_SAMPLE_FACTORS           	-	9--5	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--5
SUBJECT_SAMPLE_FACTORS           	-	9--6	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--6
SUBJECT_SAMPLE_FACTORS           	-	9--7	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--7
SUBJECT_SAMPLE_FACTORS           	-	9--8	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--8
SUBJECT_SAMPLE_FACTORS           	-	9--9	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--9
SUBJECT_SAMPLE_FACTORS           	-	9--10	Treatment:High Dose Ricin | Timepoint:8h	RAW_FILE_NAME=9--10
SUBJECT_SAMPLE_FACTORS           	-	6--3	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--3
SUBJECT_SAMPLE_FACTORS           	-	6--4	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--4
SUBJECT_SAMPLE_FACTORS           	-	6--5	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--5
SUBJECT_SAMPLE_FACTORS           	-	6--6	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--6
SUBJECT_SAMPLE_FACTORS           	-	6--7	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--7
SUBJECT_SAMPLE_FACTORS           	-	6--8	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--8
SUBJECT_SAMPLE_FACTORS           	-	6--10	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--10
SUBJECT_SAMPLE_FACTORS           	-	6--11	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--11
SUBJECT_SAMPLE_FACTORS           	-	6--12	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--12
SUBJECT_SAMPLE_FACTORS           	-	6--13	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--13
SUBJECT_SAMPLE_FACTORS           	-	6--14	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--14
SUBJECT_SAMPLE_FACTORS           	-	6--15	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--15
SUBJECT_SAMPLE_FACTORS           	-	6--16	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--16
SUBJECT_SAMPLE_FACTORS           	-	6--17	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--17
SUBJECT_SAMPLE_FACTORS           	-	6--18	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--18
SUBJECT_SAMPLE_FACTORS           	-	6--19	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--19
SUBJECT_SAMPLE_FACTORS           	-	6--20	Treatment:High Dose Ricin | Timepoint:Overnight	RAW_FILE_NAME=6--20
#COLLECTION
CO:COLLECTION_SUMMARY            	Livers were removed from mice immediately following sacrificed, and stored at
CO:COLLECTION_SUMMARY            	-80° C. Before metabolite extraction, livers were homogenized into powder with
CO:COLLECTION_SUMMARY            	mortar and pestle over liquid nitrogen.
CO:SAMPLE_TYPE                   	Liver
CO:STORAGE_CONDITIONS            	-80℃
#TREATMENT
TR:TREATMENT_SUMMARY             	Mice were injected via intraperitoneal (IP) route with either ricin or saline in
TR:TREATMENT_SUMMARY             	10 µL per g body weight. Mice in all but the fasted group were given food and
TR:TREATMENT_SUMMARY             	water ad libitum. Fasted mice were transferred to new cages with fresh bedding
TR:TREATMENT_SUMMARY             	where they had food withheld while given water ad libitum. Mice were sacrificed
TR:TREATMENT_SUMMARY             	at 2hr (ricin), 8 hr (ricin and fasted), and overnight (16-22 hr, control,
TR:TREATMENT_SUMMARY             	ricin, fasted).
TR:TREATMENT_ROUTE               	Intraperitoneal
TR:TREATMENT_DOSE                	0.6 µg/kg body weight or 30 µg/kg body weight
TR:TREATMENT_VEHICLE             	saline
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Frozen livers were homogenized in liquid nitrogen using a mortar and pestle.
SP:SAMPLEPREP_SUMMARY            	Liver powder was weighed (60-80 mg) into 2-mL microcentrifuge tubes. 900 µL of
SP:SAMPLEPREP_SUMMARY            	ice-cold 1:2 MeOH/CHCl3 was added to the liver tissue and tissue was mixed into
SP:SAMPLEPREP_SUMMARY            	suspension and lysed using a FastPrep-24TM 5G homogenizer using the S. aureus
SP:SAMPLEPREP_SUMMARY            	setting of 6.0 meters/second speed for 2 x 40 seconds. Tubes were placed back on
SP:SAMPLEPREP_SUMMARY            	ice and 200 µL of ice-cold H2O was added, before repeating the lysis step.
SP:SAMPLEPREP_SUMMARY            	Samples were then placed at -20 ºC for approximately 45 minutes to precipitate
SP:SAMPLEPREP_SUMMARY            	protein, then centrifuged at 14,000 g for 10 minutes. 250 µL of upper polar
SP:SAMPLEPREP_SUMMARY            	phase were transferred to a 1.5 mL Eppendorf tube and dried overnight using a
SP:SAMPLEPREP_SUMMARY            	Savant™ Universal SpeedVac™ vacuum system with no heat. Dried metabolite
SP:SAMPLEPREP_SUMMARY            	mixtures were re-suspended in 600 µL of NMR buffer containing 0.25 mM
SP:SAMPLEPREP_SUMMARY            	4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS), 90%H2O/10% D2O, 25 mM sodium
SP:SAMPLEPREP_SUMMARY            	phosphate, pH 7.
#ANALYSIS
AN:LABORATORY_NAME               	Copie Lab
#NMR
NM:INSTRUMENT_NAME               	Bruker Avance III Solution NMR Spectrometer
NM:INSTRUMENT_TYPE               	FT-NMR
NM:NMR_EXPERIMENT_TYPE           	1D-1H
NM:SPECTROMETER_FREQUENCY        	600.13 MHz (1H Larmor Frequency)
NM:NMR_PROBE                     	5 mm liquid-helium-cooled TCI cryoprobe with Z-gradient
NM:NMR_SOLVENT                   	0.25 mM 4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS), 90%H2O/10% D2O, 25 mM
NM:NMR_SOLVENT                   	sodium phosphate, pH 7
NM:NMR_TUBE_SIZE                 	5 mm
NM:SHIMMING_METHOD               	topshim
NM:PULSE_SEQUENCE                	zgesgp
NM:NUMBER_OF_SCANS               	256
NM:NUM_DATA_POINTS_ACQUIRED      	64K
#NMR_METABOLITE_DATA
NMR_METABOLITE_DATA:UNITS	µM/mg liver tissue
NMR_METABOLITE_DATA_START
Samples	1--2	1--3	1--4	1--5	1--6	1--7	1--8	1--9	1--10	1--11	1--12	1--13	1--14	1--15	1--16	7--1	7--2	7--3	7--4	7--5	7--6	7--7	7--8	7--9	7--10	2--1	2--2	2--3	2--4	2--5	2--6	2--7	2--8	2--9	2--10	2--11	2--12	2--13	2--14	2--15	2--16	3--1	3--2	3--3	3--4	3--5	3--6	3--7	3--8	3--9	3--10	8--1	8--2	8--3	8--4	8--5	8--6	8--7	8--8	8--9	4--1	4--2	4--3	4--4	4--5	4--6	4--7	4--8	4--9	4--10	5--1	5--2	5--3	5--4	5--5	5--6	5--7	5--8	5--9	5--10	9--1	9--2	9--3	9--4	9--5	9--6	9--7	9--8	9--9	9--10	6--3	6--4	6--5	6--6	6--7	6--8	6--10	6--11	6--12	6--13	6--14	6--15	6--16	6--17	6--18	6--19	6--20
Factors	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Control | Timepoint:Overnight	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:8h	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Fast | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:2h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:8h	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:Low Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:2h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:8h	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight	Treatment:High Dose Ricin | Timepoint:Overnight
3-Hydroxybutyrate	0.409231	0.193056	0.29186	0.313889	0.154054	0.219178	0.246809	0.303896	0.255405	0.287187	0.226054	0.204456	0.478912	0.313669	0.280593	0.307692	0.238095	0.333874	0.565724	0.354472	0.466346	0.624413	1.060656	0.954474	0.541159	1.71	1.491667	2.198333	1.723333	1.524286	1.165714	1.026667	1.405714	1.4	1.165	1.769565	2.0375	2.055325	1.857656	1.805668	1.09589	0.285	0.19875	0.26	0.25125	0.25125	0.187143	0.2675	0.185	0.3675	0.188889	0.230159	0.260465	0.254808	0.172185	0.217054	0.237785	0.186275	0.217247	0.182708	0.3	0.261667	0.268333	0.273333	0.311429	0.215556	0.193333	0.2	0.192857	0.195	0.296296	0.531695	0.244083	0.316597	0.298561	0.249052	0.418663	0.365753	0.335357	0.332461	0.316993	0.297806	0.302782	0.329545	0.234646	0.244262	0.283763	0.259494	0.323764	0.296296	0.532213	7.451613	0.558783	0.601563	0.52161	0.525268	0.458886	0.171157	0.348438	0.273973	0.462903	0.316393	0.233918	0.263158	0.250358	0.285008	0.388715
3-Hydroxyisobutyrate	0.0662	0.0375	0.0372	0.0306	0.0392	0.0384	0.0351	0.0416	0.0338	0.0471	0.014	0.0118	0.0367	0.036	0.0346	0.290424	0.300493	0.254457	0.31614	0.326829	0.294872	0.28795	0.32459	0.307692	0.330793	0.07	0.0967	0.0917	0.0833	0.0857	0.0957	0.0867	0.0971	0.0883	0.1	0.0203	0.01875	0.0221	0.0419	0.0472	0.0511	0.03	0.02	0.0271	0.0225	0.0225	0.0329	0.03625	0.01875	0.03375	0.0311	0.296825	0.324031	0.349359	0.34106	0.294574	0.309446	0.346405	0.349917	0.326264	0.0229	0.0333	0.0367	0.0133	0.0357	0	0.00833	0.00857	0.0243	0.02625	0.0437	0.0401	0.00888	0.0279	0.0252	0.0215	0.0416	0.0452	0.041	0.0406	0.0686	0.047	0.0491	0.0487	0.0488	0.0525	0.044	0.0759	0.0702	0.0602	0.035	0.274194	0.0235	0.0234	0.0238	0.023	0.0186	0.046	0.0422	0.0426	0.0339	0.0328	0.0292	0.0319	0.0372	0.0428	0.0361
4-Hydroxybenzoate	0.0323	0.0292	0.0244	0.0278	0.027	0.0301	0.0202	0.0325	0.0257	0.0471	0.00511	0.00262	0.0068	0.00144	0.00124	0.033	0.0394	0.0438	0.0399	0.0423	0.0401	0.0391	0.041	0.0392	0.0381	0.0525	0.065	0.0633	0.0567	0.05	0.0543	0.0633	0.05	0.0733	0.0683	0.0435	0.00375	0.00138	0.0012	0.00135	0.00249	0.06	0.04875	0.0514	0.04	0.045	0.0529	0.045	0.0425	0.045	0.0422	0.0413	0.0419	0.0353	0.0414	0.0403	0.0375	0.0392	0.0431	0.044	0.0186	0.0183	0.0167	0.0183	0.0171	0.0156	0.0167	0.0157	0.0143	0.03125	0.00397	0.00776	0.00148	0.00558	0.0036	0.00506	0.00883	0.0123	0.0121	0.00785	0.0556	0.0533	0.0507	0.0552	0.0457	0.0557	0.0455	0.0522	0.0478	0.0494	0.0154	0.145161	0.0152	0.01875	0.0179	0.0153	0.0172	0.0555	0.05625	0.0487	0.0629	0.0574	0.0497	0.0606	0.0515	0.061	0.0611
ADP	0.230769	0.275	0.196512	0.2375	0.254054	0.258904	0.224468	0.292208	0.221622	0.393225	0.283525	0.211009	0.458503	0.385612	0.289246	0.485086	0.47619	0.497569	0.520799	0.502439	0.371795	0.43349	0.440984	0.489796	0.42378	0.23375	0.19	0.275	0.248333	0.224286	0.347143	0.331667	0.314286	0.37	0.323333	0.252174	0.35875	0.297372	0.318182	0.315789	0.351183	0.283333	0.29125	0.291429	0.30625	0.3025	0.255714	0.36625	0.33375	0.43125	0.493333	0.614286	0.462016	0.508013	0.597682	0.508527	0.493485	0.633987	0.73466	0.569331	0.324286	0.365	0.408333	0.396667	0.338571	0.41	0.355	0.361429	0.477143	0.40875	0.404762	0.507115	0.39645	0.3947	0.356115	0.493047	0.437579	0.609589	0.534143	0.456806	0.694444	0.670846	0.765957	0.602273	0.648819	0.754098	0.676783	0.620253	0.54386	0.612654	0.333333	5.258065	0.461964	0.704688	0.66617	0.612557	0.860743	0.673534	0.660938	0.570776	0.662903	0.739344	0.625731	0.602871	0.595136	0.711697	0.336991
AMP	1.033846	1.168056	1.15814	1.276389	1.131081	1.630137	1.635106	1.52987	1.633784	1.188513	1.030651	1.057667	1.453061	1.667626	1.358467	1.55102	1.264368	1.306321	1.34609	1.255285	1.628205	2.153365	2.140984	2.050235	1.809451	0.74125	0.663333	1.083333	0.625	0.94	1.462857	1.69	1.535714	2.273333	1.675	1.384058	1.5575	1.529737	1.801435	1.785425	2.052304	1.511667	1.375	1.331429	1.30125	1.30125	1.52	1.7475	1.51	2.14125	1.932222	1.412698	1.60155	1.246795	1.443709	1.376744	1.736156	1.591503	1.447761	1.87602	1.412857	1.655	1.876667	1.545	1.601429	1.874444	1.69	1.614286	1.407143	1.695	1.096561	1.783959	0.835799	1.249651	1.308153	1.372946	1.65826	1.80137	2.119879	1.83377	1.423203	1.490596	1.903437	1.314935	1.529134	2.186885	1.877086	2.261076	2.786284	1.834877	0.809524	15.064516	1.344398	1.957813	2.235469	2.154671	2.480106	1.933439	2.276563	1.844749	1.972581	1.67541	1.421053	1.223285	1.170243	1.443163	1.431034
ATP	0.198462	0.2875	0.226744	0.234722	0.201351	0.242466	0.356383	0.128571	0.391892	0.156112	0.108557	0.115334	0.0952	0.117986	0.106304	0.0675	0.0985	0.12966	0.0832	0.0959	0.0705	0.0595	0.0803	0.0738	0.0976	0.20375	0.145	0.228333	0.186667	0.18	0.19	0.17	0.194286	0.266667	0.341667	0.102899	0.10125	0.0581	0.0849	0.0823	0.0922	0.3	0.225	0.215714	0.21375	0.2175	0.265714	0.24375	0.22125	0.2525	0.152222	0.160317	0.147287	0.113782	0.107616	0.0899	0.109121	0.101307	0.114428	0.12398	0.268571	0.228333	0.221667	0.273333	0.201429	0.208889	0.276667	0.255714	0.28	0.19	0.199735	0.241915	0.0784	0.0837	0.142686	0.0936	0.0984	0.1	0.127466	0.129581	0.138889	0.0987	0.152209	0.12013	0.148031	0.198361	0.151745	0.125	0.14992	0.137346	0.0924	1.677419	0.149378	0.153125	0.137109	0.128637	0.168435	0.110935	0.0953	0.0928	0.0984	0.0639	0.0585	0.0574	0.0773	0.0758	0.117555
Acetate	1.095385	1.023611	1.416279	0.9125	0.604054	0.652055	0.544681	0.750649	0.591892	0.44919	0.167305	0.171691	0.587755	0.486331	0.478368	1.22135	1.2578	1.275527	1.33777	1.227642	1.253205	1.474178	1.809836	1.44898	1.407012	0.78625	0.838333	0.916667	0.728333	0.735714	0.754286	0.788333	0.787143	0.958333	1.06	0.633333	0.29	0.255878	0.33134	0.310391	0.508095	0.603333	0.41625	0.551429	0.40875	0.40875	0.575714	0.59375	0.4825	0.63	1.007778	1.234921	1.337984	1.421474	1.427152	1.128682	1.661238	1.627451	1.665008	1.681892	0.28	0.291667	0.29	0.233333	0.262857	0.385556	0.788333	0.308571	0.371429	0.6	1.298942	1.460543	0.815089	1.04463	1.257794	1.489254	1.721311	1.813699	1.3217	1.496073	1.001634	0.805643	1.116203	0.681818	0.988976	1.029508	1.051593	0.993671	1.406699	1.037037	1.180672	13.903226	1.551867	0.765625	1.420268	1.315467	1.197613	0.380349	0.620313	0.525114	0.614516	0.62459	0.557018	0.421053	0.436338	0.502471	0.445141
Alanine	4.715385	4.472222	4.22907	4.566667	3.421622	3.335616	2.868085	2.662338	4.401351	3.298969	3.077905	3.158585	4.155102	4.110791	3.53152	2.731554	3.559934	2.171799	1.69218	2.173984	1.634615	1.696401	1.345902	1.315542	1.346037	3.04375	3.631667	3.206667	2.93	3.112857	2.428571	2.015	2.614286	2.461667	3.866667	2.03913	2.385	2.295989	2.354067	2.520918	2.326276	6.048333	4.09875	4.508571	3.38875	3.38875	4.157143	4.34875	3.38125	3.9925	3.313333	3.314286	3.108527	2.899038	2.854305	2.390698	2.63355	2.718954	2.691542	2.781403	3.807143	4.076667	3.681667	3.846667	3.112857	4.257778	4.111667	3.202857	3.557143	3.24	3.498677	4.688228	1.223373	3.100418	3.701439	3.475348	4.92686	5.352055	5.992413	5.158377	3.730392	2.805643	3.572831	2.667208	2.87874	2.996721	2.811836	2.19462	2.620415	3.027778	3.964986	28.16129	2.437068	2.014063	1.545455	1.618683	1.375332	2.459588	1.795313	1.392694	1.1	1.457377	1.940058	1.795853	2.281831	2.555189	2.39185
Aspartate	0.276923	0.190278	0.295349	0.261111	0.262162	0.286301	0.329787	0.314286	0.381081	0.231222	0.229885	0.180865	0.263946	0.188489	0.161928	0.394035	0.330049	0.270665	0.242928	0.268293	0.360577	0.338028	0.452459	0.370487	0.490854	0.31	0.491667	0.366667	0.348333	0.365714	0.401429	0.421667	0.541429	0.636667	0.446667	0.242029	0.2275	0.230982	0.261962	0.252362	0.211706	0.17	0.23875	0.184286	0.225	0.225	0.524286	0.46125	0.27875	0.41375	0.424444	0.21746	0.249612	0.227564	0.261589	0.226357	0.289902	0.323529	0.268657	0.278956	0.132857	0.318333	0.2	0.295	0.165714	0.305556	0.418333	0.287143	0.231429	0.2675	0.179894	0.282018	0.0621	0.188285	0.236211	0.288243	0.287516	0.312329	0.286798	0.339005	0.411765	0.416928	0.441899	0.366883	0.43622	0.35082	0.38695	0.438291	0.572568	0.296296	1.196078	7.822581	0.608575	0.435938	0.38003	0.679939	0.437666	0.321712	0.404688	0.418569	0.437097	0.444262	0.415205	0.419458	0.39628	0.433278	0.666144
Benzoate	0.0138	0.0194	0.101163	0.00833	0.00946	0.0137	0.0543	0.0104	0.0135	0.108984	0.0805	0.0708	0.129252	0.138129	0.118665	0.177394	0.17734	0.228525	0.198003	0.222764	0.225962	0.241002	0.267213	0.210361	0.155488	0.15625	0.195	0.233333	0.2	0.172857	0.117143	0.166667	0.142857	0.218333	0.22	0.118841	0.13875	0.15491	0.147129	0.153846	0.154421	0.223333	0	0.192857	0.15875	0.16	0.214286	0.1775	0.18875	0.17375	0.146667	0.196825	0.212403	0.208333	0.18543	0.19845	0.223127	0.238562	0.228856	0.23491	0.197143	0.178333	0.218333	0.173333	0.207143	0.156667	0.23	0.172857	0.167143	0	0.23545	0.188875	0.309172	0.311018	0.18705	0.217446	0.176545	0.223288	0.230653	0.232984	0.210784	0.202194	0.188216	0.204545	0.16378	0.190164	0.165402	0.223101	0.23764	0.182099	0.229692	2.129032	0.210235	0.235938	0.23845	0.269525	0.212202	0.103011	0.14375	0.14003	0.169355	0.27541	0.125731	0.114833	0.123033	0.131796	0.137931
Betaine	2.906154	2.727778	2.265116	2.429167	0.87973	1.182192	1.106383	1.167532	0.972973	1.067747	1.268199	1.301442	1.647619	1.020144	1.457355	0.766091	0.881773	0.841167	0.900166	1.320325	1.477564	1.061033	1.885246	1.285714	0.934451	0.6675	1.118333	1.668333	0.83	1.131429	0.767143	0.696667	0.795714	1.028333	0.723333	0.898551	1.03125	1.713693	1.100478	0.955466	0.838107	1.738333	1.74375	1.39	1.2975	1.2975	1.447143	1.28625	1.00125	1.83375	1.835556	1.109524	1.165891	1.121795	1.319536	1.181395	1.086319	1.148693	0.91874	0.836868	1.331429	1.56	0.96	1.076667	1.421429	1.49	0.778333	0.88	0.941429	1.56875	0.90873	2.350582	0.576923	0.845188	1.863309	1.05689	1.278689	1.212329	1.204856	1.204188	0.73366	0.60815	0.713584	0.594156	0.817323	0.942623	0.995448	0.947785	1.245614	1.054012	2.441176	21.66129	2.414938	1.6625	1.549925	2.686064	2.058355	1	0.765625	0.642314	0.779032	0.886885	0.587719	0.917065	0.822604	0.591433	0.979624
Cadaverine	0.104615	0.0514	0.0767	0.0778	0.0311	0.0836	0.0383	0.0481	0.0189	0.0457	0.0192	0.017	0.0327	0.0345	0.0309	0.0471	0.0312	0.047	0.0399	0.0341	0.0208	0.0376	0.023	0.0235	0.0305	0.025	0.02	0.0467	0.02	0.0214	0.0343	0.136667	0.0257	0.02	0.04	0.029	0.03	0.0277	0.0395	0.0283	0.0274	0.0567	0.0325	0.0257	0.04375	0.03625	0.0286	0.03875	0.025	0.045	0.0333	0.027	0.0388	0.0401	0.0298	0.0403	0.0261	0.0359	0.0282	0.0294	0.0371	0.0517	0.025	0.025	0.0314	0.0311	0.00833	0.0271	0.0271	0.05375	0.0265	0.0427	0.0104	0.0391	0.03	0.0316	0.0378	0.0342	0.0455	0.051	0.0539	0.0266	0.036	0.0227	0.0189	0.0475	0.041	0.0364	0.0255	0.0432	0.0196	0.177419	0.018	0.021875	0.0134	0.00919	0.0159	0.0301	0.021875	0.0137	0.0226	0.0197	0.0249	0.0255	0.03	0.0313	0.0094
Carnitine	0.733846	0.636111	0.510465	0.513889	0.374324	0.369863	0.4	0.397403	0.381081	0.521355	0.376756	0.294889	0.284354	0.300719	0.258344	0.397174	0.385878	0.372771	0.374376	0.35935	0.304487	0.305164	0.316393	0.312402	0.280488	0.51625	0.638333	0.861667	0.53	0.614286	0.484286	0.445	0.487143	0.571667	0.535	0.33913	0.43875	0.755187	0.380383	0.37247	0.389788	0.718333	0.585	0.567143	0.62625	0.62625	0.428571	0.4025	0.38875	0.47125	0.406667	0.533333	0.468217	0.583333	0.523179	0.451163	0.410423	0.313725	0.379768	0.349103	0.687143	0.705	0.703333	0.588333	0.525714	0.504444	0.435	0.431429	0.478571	0.375	0.425926	0.545925	0.178994	0.401674	0.553957	0.402023	0.340479	0.317808	0.370258	0.281414	0.638889	0.377743	0.463175	0.23539	0.555906	0.340984	0.254932	0.416139	0.443381	0.345679	0.438375	6.064516	0.525588	0.58125	0.624441	0.609495	0.477454	0.348653	0.45	0.350076	0.45	0.331148	0.461988	0.489633	0.555079	0.5486	0.396552
Cholate	0.776923	0.354167	0.15	0.516667	0.209459	0.175342	0.335106	0.281818	0.132432	0.194404	0.324393	0.137615	0.752381	0.353957	0.145859	1.524333	0.292282	2.732577	2.487521	2.481301	0.913462	0.528951	0.598361	0.709576	0.868902	0.5575	0.558333	0.486667	0.92	0.28	1.101429	1.005	1.055714	0.168333	0.295	0.144928	1.125	0.222683	0.0981	0.527665	0.442092	0.58	0.77625	0.8	0.72125	0.72125	0.282857	0.14	0.23125	0.33625	0.0811	1.64127	0.826357	1.483974	2.031457	0.407752	0.363192	0.434641	0.228856	0.352365	0.17	1.196667	0.435	0.433333	0.824286	0.105556	0.185	0.195714	0.114286	0.08625	0.384921	0.827943	0.158284	0.126918	0.931655	0.115044	0.286255	0.110959	0.115326	0.0681	0.397059	0.399687	0.328969	0.724026	0.0866	0.168852	0.14871	0.128165	0.167464	0.112654	0.109244	1.080645	0.0885	0.0234	0.0566	0.0322	0.0199	0.291601	0.075	0.0776	0.0565	0.0475	0.0614	0.0702	0.0858	0.125206	0.5
Choline	0.547692	0.238889	0.272093	0.316667	0.243243	0.472603	0.404255	0.492208	0.42973	0.166421	0.111111	0.100917	0.376871	0.258993	0.241038	0.461538	0.522167	0.58671	0.404326	0.395122	0.532051	1.28169	0.763934	1.078493	0.942073	0.545	0.523333	0.568333	0.463333	0.565714	0.61	0.556667	0.534286	0.573333	0.716667	0.397101	0.35625	0.427386	0.569378	0.51417	0.559153	0.316667	0.21625	0.275714	0.26125	0.2275	0.584286	0.36625	0.3975	0.63875	0.356667	0.2	0.189147	0.217949	0.190397	0.178295	0.345277	0.302288	0.190713	0.342577	0.407143	0.451667	0.418333	0.405	0.395714	0.558889	0.47	0.318571	0.242857	0.32625	0.149471	0.232859	0.071	0.129707	0.206235	0.271808	0.351828	0.263014	0.298938	0.299738	0.531046	0.399687	0.495908	0.413961	0.549606	0.470492	0.359636	0.97943	1.044657	0.532407	0.743697	3.564516	0.598893	0.45	0.675112	0.387443	0.401857	0.278922	0.601563	0.537291	0.556452	0.25082	0.397661	0.355662	0.354793	0.390445	0.512539
Creatine	0.516923	1.7875	0.326744	0.538889	0.887838	0.610959	0.36383	0.425974	0.283784	0.434462	0.302682	0.201835	0.261224	0.305036	0.273177	0.307692	0.431856	0.518639	0.469218	0.263415	0.610577	0.267606	0.385246	0.254317	0.262195	0.68875	0.455	1.025	0.568333	0.532857	0.75	0.478333	1.128571	0.506667	1.141667	0.328986	0.41625	0.576763	0.405502	0.591093	0.326276	0.743333	0.7275	0.344286	0.385	0.35	0.461429	0.48	0.4375	0.6525	0.953333	0.838095	0.457364	0.270833	0.518212	0.734884	0.571661	0.264706	0.532338	0.368679	0.941429	0.99	0.646667	1.456667	0.61	1.19	0.645	1.102857	0.865714	0.55875	0.251323	0.355757	0.16568	0.308229	0.423261	0.249052	0.476671	0.453425	0.588771	0.291885	0.542484	0.446708	0.490998	0.589286	0.896063	0.513115	0.368741	0.371835	0.527911	0.540123	0.991597	18.83871	1.533887	2.198438	2.055142	2.189893	1.962865	0.299525	1.221875	1.339422	1.732258	1.760656	1.05848	1.346093	1.074392	1.650741	1.755486
Dimethylamine	0.247692	0.316667	0.22907	0.233333	0.172973	0.20274	0.0947	0.172727	0.0716	0.12813	0.108557	0.132372	0.157823	0.189928	0.138443	0.21978	0.178982	0.23825	0.206323	0.180488	0.149038	0.203443	0.139344	0.133438	0.184451	0.23875	0.25	0.275	0.225	0.137143	0.184286	0.225	0.194286	0.221667	0.21	0.0058	0.11625	0.0553	0.111244	0.0688	0.156912	0.25	0.16375	0.00714	0.17375	0.17375	0.227143	0.22	0.2	0.1325	0.138889	0.131746	0.189147	0.190705	0.135762	0.275969	0.20684	0.207516	0.19403	0.202284	0.188571	0.25	0.216667	0.235	0.212857	0.141111	0.221667	0.198571	0.171429	0.16625	0.26455	0.244502	0.034	0.308229	0.21223	0.212389	0.17024	0.254795	0.353566	0.147906	0.179739	0.0987	0.10311	0.102273	0.0992	0.106557	0.0956	0.0949	0.100478	0.165123	0.284314	1.983871	0.193638	0.159375	0.199702	0.173047	0.15252	0.120444	0.123438	0.115677	0.124194	0.121311	0.108187	0.111643	0.100143	0.120264	0.109718
Formate	0.06	0.0556	0.0465	0.0361	0.0189	0.0178	0.00106	0.0013	0.00135	0.136966	0.0243	0.0249	0.0408	0.0446	0.0383	0.142857	0.152709	0.155592	0.159734	0.0959	0.121795	0.122066	0.155738	0.164835	0.160061	0.25	0.37	0.468333	0.306667	0.39	0.254286	0.305	0.331429	0.35	0.365	0.155072	0.07875	0.105118	0.0897	0.103914	0.0672	0.25	0.1575	0.195714	0.1525	0.13	0.164286	0.15625	0.1425	0.16125	0.162222	0.11746	0.105426	0.108974	0.112583	0.0992	0.118893	0.124183	0.117745	0.127243	0.118571	0.135	0.188333	0.168333	0.12	0.107778	0.156667	0.128571	0.104286	0.21375	0.0939	0.12031	0.868343	0.129707	0.0635	0.0645	0.0656	0.0863	0.118361	0.0798	0.125817	0.0878	0.130933	0.0617	0.0803	0.0787	0.104704	0.112342	0.111643	0.0741	0.123249	0.951613	0.0788	0.09375	0.082	0.134763	0.145889	0.0681	0.084375	0.0822	0.0871	0.0705	0.0629	0.0686	0.0615	0.0774	0.0737
Fumarate	0.161538	0.129167	0.123256	0.0986	0.102703	0.10137	0.126596	0.107792	0.167568	0.0943	0.0613	0.055	0.0367	0.0388	0.0433	0.0204	0.0246	0.0194	0.0166	0.013	0.0337	0.00626	0.018	0.0204	0.0244	0.05875	0.055	0.06	0.0483	0.06	0.0329	0.035	0.0514	0.0483	0.09	0.0594	0.0075	0.00968	0.0156	0.0162	0.0286	0.05	0.0325	0.0243	0.0375	0.0375	0.0743	0.07	0.065	0.0575	0.0744	0.0508	0.0667	0.0593	0.0414	0.0403	0.0635	0.0719	0.0813	0.0506	0.03	0.055	0.0333	0.08	0.0343	0.0422	0.143333	0.0857	0.0829	0.09375	0.0251	0.0207	0.0325	0.0209	0.0324	0.0531	0.0404	0.0507	0.0895	0.0484	0.0523	0.0486	0.0491	0.0503	0.0583	0.0967	0.091	0.0554	0.0447	0.108025	0.0826	0.629032	0.0733	0.114063	0.0894	0.119449	0.0663	0.0317	0.05625	0.0548	0.0565	0.0787	0.0556	0.075	0.0773	0.089	0.0721
GTP	0.0277	0.0167	0.0349	0.0167	0.0284	0.0452	0.0223	0.0143	0.0338	0.0309	0.023	0.0249	0.0327	0.0345	0.0297	0.0283	0.0181	0.00972	0.0116	0.0358	0.0321	0.0172	0.0246	0.0235	0.0229	0.01625	0.03	0.00833	0.025	0.0257	0.0157	0.0283	0.0257	0.035	0.0333	0.0377	0.0325	0.036	0.0275	0.031	0.0286	0.00167	0.02875	0.02	0.01625	0.01625	0.0214	0.03625	0.025	0.02125	0.0256	0.0254	0.014	0.0144	0.0248	0.0233	0.0277	0.0327	0.0249	0.0245	0.00143	0.025	0.025	0.02	0.0143	0.0167	0.03	0.0257	0.0243	0.02875	0.0278	0.0272	0.0281	0.0237	0.0276	0.0367	0.0366	0.0301	0.0425	0.034	0.0294	0.0313	0.0327	0.0325	0.0315	0.0328	0.0516	0.0222	0.0319	0.0278	0.014	0.16129	0.0263	0.04375	0.0522	0.0536	0.0385	0.0158	0.015625	0.0152	0.0161	0.0328	0.0292	0.0383	0.0343	0.0395	0.0251
Glucose	54.544615	36.425	29.748837	26.294444	32.101351	45.075342	32.434043	36.375325	37.351351	31.269514	26.916986	26.132372	34.058503	36.018705	38.92089	4.180534	2.275862	5.262561	5.402662	6.894309	2.592949	2.050078	1.806557	1.99843	2.57622	13.28	10.331667	8.421667	12.128333	10.948571	8.392857	8.601667	10.422857	9.973333	20.588333	7.886957	12.5075	4.125864	12	6.48583	22.011208	26.176667	20.45	16.905714	20.63625	20.63625	16.974286	22.7825	16.7	17.73375	21.001111	11.536508	15.308527	13.554487	11.933775	12.950388	14.579805	10.594771	11.444444	7.712887	20.484286	26.146667	25.965	23.42	22.71	22.217778	18.153333	25.24	26.514286	26.66875	19.433862	31.280724	17.689349	19.580195	28.839329	20.903919	22.566204	23.7	29.68437	21.801047	7.740196	5.247649	5.08838	4.459416	3.601575	17.285246	13.532625	3.294304	2.99681	7.884259	1.065826	26.435484	2.766252	5.428125	3.561848	2.433384	2.45756	15.472266	4.421875	3.590563	2.653226	3.781967	3.701754	4.143541	5.776824	6.998353	3.180251
Glutamate	0.790769	0.572222	0.498837	0.651389	0.340541	0.430137	0.518085	0.366234	0.601351	0.67894	0.578544	0.554391	0.55102	0.411511	0.527812	0.726845	1.022989	0.752026	0.738769	0.554472	0.798077	1.170579	0.97541	1.197802	1.16311	0.6375	0.733333	0.783333	0.676667	0.805714	0.448571	0.471667	0.622857	0.776667	0.791667	0.982609	0.72125	0.791148	0.894737	0.765182	0.673724	0.891667	0.69875	0.701429	0.65125	0.665	1.487143	0.665	0.5375	0.8325	0.828889	0.673016	0.699225	0.692308	0.668874	0.562791	0.669381	0.637255	0.671642	0.631321	0.804286	0.898333	0.735	0.996667	0.688571	0.684444	0.753333	0.557143	0.474286	0.4625	0.519841	0.711514	0.273669	0.521618	0.706235	0.830594	0.953342	0.828767	0.93475	0.778796	1.205882	0.982759	1.319149	1.006494	1.327559	0.906557	0.742033	1.525316	1.634769	0.915123	2.697479	20.16129	2.218534	0.767188	0.700447	1.411945	0.786472	0.62916	0.709375	0.687976	0.779032	0.944262	0.931287	0.859649	0.95279	0.853377	1.214734
Glutamine	1.232308	0.577778	0.656977	0.705556	0.864865	1.369863	1.196809	1.231169	2.293243	1.297496	1.215837	1.183486	1.12517	0.935252	0.970334	1.208791	0.802956	1.050243	1.191348	1.206504	1.322115	1.312989	1.540984	1.285714	1.390244	1.35875	1.446667	1.61	1.503333	1.495714	1.28	1.233333	1.495714	1.626667	1.621667	2.073913	1.29	1.304288	1.702153	1.419703	1.499377	1.253333	1.345	1.104286	1.1775	1.1775	1.555714	2.215	1.4325	1.95625	1.865556	0.787302	0.765891	0.974359	0.998344	0.706977	1.276873	1.441176	1.356551	1.378467	1.334286	1.53	1.051667	1.241667	1.287143	1.555556	1.936667	1.442857	0.965714	0.74125	1.002646	0.905563	0.420118	0.934449	0.911271	1.154235	1.240858	1.379452	2.496206	1.450262	2.168301	1.940439	2.207856	1.923701	2.119685	2.422951	1.734446	1.427215	1.889952	1.617284	1.52521	22.322581	1.798064	1.29375	0.983607	1.376723	1.270557	1.508716	1.339063	1.284627	1.419355	1.778689	1.912281	1.821372	1.633763	1.764415	2.07837
Glutathione	2.766154	2.3375	2.256977	1.720833	1.772973	2.382192	1.667021	2.006494	2.736486	2.724595	2.422733	2.360419	3.204082	2.761151	2.540173	1.740973	1.039409	1.23987	1.440932	0.95935	0.655449	0.816901	0.852459	0.750392	0.990854	1.3825	1.308333	0.953333	1.22	1.227143	1.147143	0.831667	0.88	1.128333	1.376667	1.486957	1.53875	1.542185	1.348086	1.25641	1.494396	2.021667	1.87375	1.742857	1.7075	1.7075	0.685714	1.5625	1.5975	1.815	1.881111	2.053968	1.846512	1.911859	2.269868	1.64031	1.664495	1.477124	1.257048	1.323002	2.01	2.623333	2.85	2.266667	1.832857	1.885556	1.866667	2.454286	2.122857	1.7225	2.011905	2.92238	0.448225	1.680614	2.311751	2.102402	2.679697	2.642466	3.00607	2.942408	3.035948	2.065831	2.765957	2.097403	1.914961	1.785246	1.837633	1.128165	1.655502	1.237654	1.768908	26.967742	2.362379	1.41875	1.068554	0.880551	1.083554	2.082409	1.232813	1.200913	0.853226	1.290164	1.179825	1.483254	2	1.912685	1.688088
Glycerol	0.975385	0.536111	0.369767	0.368056	0.374324	0.521918	0.687234	0.507792	0.259459	0.357879	0.255428	0.325033	0.393197	0.385612	0.567367	0.248038	0.303777	0.377634	0.291181	0.235772	0.373397	0.522692	0.521311	0.472527	0.379573	0.54375	0.375	0.358333	0.38	0.352857	0.557143	0.465	0.572857	0.438333	0.606667	0.526087	0.67375	0.48686	0.57177	0.635628	0.986301	0.65	0.4925	0.304286	0.415	0.30125	0.337143	0.24	0.2625	0.3825	0.25	0.290476	0.511628	0.246795	0.306291	0.291473	0.568404	0.392157	0.33665	0.360522	0.255714	0.218333	0.211667	0.161667	0.202857	0.174444	0.156667	0.237143	0.284286	0.2575	0.502646	0.880983	0.319527	0.531381	0.736211	0.451327	0.906683	0.510959	0.75569	0.48822	0.526144	0.257053	0.343699	0.332792	0.289764	0.472131	0.37481	0.463608	0.599681	0.552469	0.441176	1.725806	0.308437	0.225	0.292101	0.137825	0.104775	0.412044	0.270313	0.25723	0.272581	0.186885	0.188596	0.205742	0.158798	0.281713	0.612853
Glycine	1.755385	1.540278	1.386047	1.594444	1.440541	1.612329	1.978723	1.703896	2.413514	1.237113	1.265645	1.179554	1.941497	1.538129	1.469716	1.310832	1.380952	1.440843	1.479201	1.261789	2.30609	2.28482	2.347541	2.015699	2.152439	1.9975	2.175	2.436667	1.958333	2.251429	2.754286	2.528333	2.44	2.996667	3.521667	1.572464	1.6375	1.741355	2.379187	3.013495	2.496887	1.636667	1.5375	1.694286	1.495	1.495	3.907143	2.1775	1.79	2.37875	2.261111	1.253968	1.206202	1.224359	1.425497	1.181395	1.786645	1.379085	1.597015	2.011419	1.457143	1.511667	1.601667	1.696667	1.392857	2.006667	1.995	1.85	1.445714	1.485	1.26455	1.452781	0.531065	1.179916	1.616307	1.785082	1.93947	1.856164	2.250379	1.689791	1.98366	1.61442	1.949264	1.672078	1.555906	2.285246	1.962064	2.060127	2.574163	1.981481	1.635854	12.935484	1.356846	1.3	1.247392	1.07657	1.192308	1.675119	1.451563	1.245053	1.282258	1.022951	1.20614	1.100478	1.237482	1.308072	1.974922
Histidine	0.296923	0.243056	0.266279	0.331944	0.204054	0.293151	0.243617	0.215584	0.402703	0.369661	0.375479	0.328965	0.390476	0.313669	0.28801	0.370487	0.348112	0.264182	0.241265	0.263415	0.288462	0.395931	0.363934	0.313972	0.318598	0.29875	0.3	0.338333	0.253333	0.26	0.265714	0.21	0.224286	0.321667	0.3	0.407246	0.25875	0.340249	0.388756	0.394062	0.32254	0.425	0.3775	0.38	0.3425	0.3425	0.381429	0.41	0.29625	0.385	0.356667	0.347619	0.303876	0.282051	0.304636	0.255814	0.330619	0.424837	0.38806	0.384992	0.328571	0.36	0.325	0.385	0.257143	0.317778	0.445	0.335714	0.232857	0.2125	0.239418	0.282018	0.113905	0.218968	0.22542	0.2933	0.326608	0.430137	0.424886	0.374346	0.454248	0.333856	0.391162	0.293831	0.330709	0.440984	0.443096	0.424051	0.513557	0.432099	0.596639	6.451613	0.55325	0.553125	0.52161	0.759571	0.644562	0.286846	0.46875	0.38965	0.462903	0.477049	0.346491	0.331738	0.327611	0.365733	0.438871
IMP	0.206154	0.679167	0.2	0.373611	0.389189	0.452055	0.284043	0.34026	0.251351	0.241532	0.154534	0.0944	0.227211	0.185612	0.173053	0.22606	0.174056	0.231767	0.322795	0.170732	0.274038	0.181534	0.25082	0.139717	0.240854	0.19625	0.166667	0.313333	0.22	0.252857	0.48	0.413333	0.56	0.451667	1.008333	0.153623	0.1725	0.157676	0.26555	0.278003	0.22665	0.471667	0.4175	0.172857	0.19375	0.2125	0.402857	0.3225	0.2275	0.5175	0.421111	0.401587	0.170543	0.176282	0.230132	0.226357	0.309446	0.297386	0.318408	0.340946	0.684286	0.611667	0.358333	0.868333	0.405714	0.86	0.413333	0.582857	0.494286	0.26375	0.146825	0.097	0.0607	0.0809	0.161871	0.102402	0.121059	0.131507	0.218513	0.125654	0.281046	0.221003	0.284779	0.219156	0.338583	0.327869	0.277693	0.186709	0.263158	0.33642	0.0336	1.516129	0.163209	0.403125	0.408346	0.185299	0.214854	0.328051	0.25	0.315068	0.330645	0.240984	0.289474	0.242424	0.228898	0.372323	0.211599
Inosine	1.358462	0.816667	0.745349	0.706944	0.418919	0.50137	0.524468	0.583117	0.416216	0.5081	0.284802	0.269987	0.395918	0.407194	0.407911	0.416013	0.573071	0.525122	0.524126	0.521951	0.38141	0.471049	0.481967	0.486656	0.51372	1.08625	1.193333	1.236667	1.088333	1.187143	0.668571	0.438333	0.574286	0.501667	0.83	0.373913	0.35375	0.500692	0.433014	0.37247	0.419676	0.956667	0.57	0.742857	0.80375	0.80375	0.642857	0.39875	0.37625	0.455	0.295556	0.35873	0.311628	0.434295	0.349338	0.243411	0.439739	0.357843	0.25539	0.243067	0.615714	0.806667	0.63	0.415	0.538571	0.357778	0.253333	0.315714	0.338571	0.2925	0.376984	0.627426	0.127219	0.274756	0.585132	0.228824	0.228247	0.250685	0.242792	0.256545	0.558824	0.322884	0.325696	0.295455	0.289764	0.391803	0.288316	0.243671	0.355662	0.262346	0.27451	4.564516	0.488243	0.278125	0.372578	0.303216	0.189655	0.272583	0.189063	0.18417	0.145161	0.14918	0.133041	0.173844	0.224607	0.214168	0.213166
Isoleucine	0.229231	0.191667	0.163953	0.186111	0.122973	0.187671	0.16383	0.172727	0.22027	0.20324	0.189017	0.145478	0.160544	0.155396	0.112485	0.186813	0.154351	0.184765	0.108153	0.112195	0.134615	0.302034	0.22623	0.178964	0.21189	0.14125	0.15	0.158333	0.141667	0.18	0.222857	0.15	0.15	0.165	0.235	0.169565	0.07375	0.146611	0.253589	0.263158	0.174346	0.183333	0.1475	0.162857	0.15625	0.15625	0.225714	0.28375	0.12375	0.195	0.164444	0.103175	0.11938	0.123397	0.102649	0.0961	0.169381	0.20098	0.144279	0.168026	0.132857	0.15	0.148333	0.141667	0.118571	0.133333	0.176667	0.134286	0.118571	0.11	0.126984	0.111255	0.0459	0.0976	0.0983	0.111252	0.148802	0.138356	0.179059	0.132199	0.218954	0.163009	0.145663	0.108766	0.149606	0.295082	0.300455	0.289557	0.328549	0.282407	0.261905	2.870968	0.246196	0.198438	0.217586	0.32925	0.311671	0.158479	0.239063	0.205479	0.229032	0.231148	0.135965	0.137161	0.141631	0.143328	0.18652
Lactate	22.647692	26.294444	19.559302	19.552778	20.164865	19.310959	16.275532	18.942857	19.05	12.447717	11.404853	9.597641	15.122449	15.473381	15.332509	6.524333	5.937603	7.019449	5.628952	6.889431	3.330128	2.669797	2.419672	2.452119	2.669207	10.95375	9.825	9.165	8.905	7.377143	7.994286	6.876667	8.421429	7.556667	16.65	4.43913	8.76875	5.510373	7.307416	5.985155	11.622665	26.428333	19.7925	17.357143	17.11625	17.11625	19.234286	20.075	13.50625	15.69125	17.291111	13.863492	13.955039	13.977564	2.586093	11.976744	12.234528	11.673203	12.515755	12.225122	19.325714	16.855	19.861667	18.341667	15.611429	20.613333	14.363333	17.671429	19.291429	18.1025	16.32672	20.57956	8.565089	14.750349	20.898082	13.844501	17.007566	19.260274	21.062215	17.435864	15.035948	9.587774	10.252046	7.310065	8.505512	17.427869	12.054628	4.18038	7.181818	10.160494	6.690476	55.806452	6.427386	10.504688	7.064083	7.258806	3.840849	13.435816	6.00625	5.634703	3.677419	5.168852	6.273392	6.700159	8.474964	10.383855	9.87931
Leucine	0.458462	0.393056	0.317442	0.393056	0.344595	0.423288	0.454255	0.457143	0.375676	0.372607	0.335888	0.259502	0.473469	0.348201	0.299135	0.397174	0.224959	0.32577	0.430948	0.421138	0.400641	0.635368	0.688525	0.659341	0.643293	0.31625	0.405	0.418333	0.373333	0.347143	0.47	0.348333	0.437143	0.343333	0.511667	0.27971	0.32625	0.278008	0.47488	0.535762	0.494396	0.45	0.23125	0.24	0.22625	0.2225	0.377143	0.46	0.27	0.37125	0.303333	0.28254	0.339535	0.315705	0.349338	0.186047	0.465798	0.452614	0.396352	0.424144	0.291429	0.236667	0.221667	0.16	0.171429	0.258889	0.303333	0.27	0.207143	0.18	0.202381	0.214748	0.0991	0.174338	0.193046	0.214918	0.326608	0.236986	0.282246	0.336387	0.441176	0.318182	0.302782	0.279221	0.261417	0.504918	0.591806	0.525316	0.523126	0.521605	0.492997	5.419355	0.471646	0.4	0.454545	0.574273	0.555703	0.301109	0.439063	0.39726	0.420968	0.378689	0.273392	0.250399	0.276109	0.281713	0.363636
Lysine	0.293846	0.229167	0.20814	0.266667	0.132432	0.175342	0.173404	0.164935	0.283784	0.234168	0.247765	0.19135	0.204082	0.166906	0.132262	0.398744	0.469622	0.241491	0.272879	0.269919	0.233974	0.464789	0.383607	0.260597	0.335366	0.15375	0.193333	0.193333	0.155	0.214286	0.215714	0.178333	0.16	0.205	0.255	0.333333	0.1625	0.185339	0.232057	0.265857	0.171856	0.37	0.23125	0.275714	0.29	0.27375	0.278571	0.2675	0.1475	0.2675	0.187778	0.279365	0.24031	0.222756	0.206954	0.213953	0.241042	0.26634	0.228856	0.228385	0.181429	0.213333	0.208333	0.293333	0.177143	0.183333	0.326667	0.205714	0.151429	0.1875	0.132275	0.181113	0.115385	0.124128	0.125899	0.166877	0.213115	0.194521	0.261002	0.247382	0.526144	0.45768	0.486088	0.353896	0.395276	0.390164	0.397572	0.469937	0.491228	0.45216	1.002801	6.322581	0.477178	0.321875	0.330849	0.565084	0.498674	0.229794	0.392188	0.255708	0.293548	0.32459	0.280702	0.196172	0.300429	0.270181	0.302508
Malate	0.643077	0.288889	0.437209	0.255556	0.310811	0.231507	0.492553	0.306494	0.306757	0.618557	0.417625	0.251638	0.357823	0.34964	0.375773	0.346939	0.34647	0.213938	0.281198	0.201626	0.479167	0.13302	0.252459	0.282575	0.375	0.325	0.281667	0.311667	0.281667	0.164286	0.14	0.173333	0.284286	0.22	0.59	0.311594	0.29125	0.443983	0.41866	0.403509	0.524284	0.375	0.3475	0.248571	0.27375	0.285	0.577143	0.655	0.66	0.67875	1.018889	0.666667	0.87907	0.820513	0.798013	0.683721	0.705212	0.883987	0.854063	0.613377	0.297143	0.488333	0.261667	0.445	0.335714	0.484444	0.595	0.565714	0.778571	0.9525	0.219577	0.404916	0.170118	0.329149	0.586331	0.835651	0.672131	0.936986	0.775417	0.959424	0.707516	0.568966	0.824877	0.590909	0.823622	0.816393	0.869499	0.632911	0.652313	0.99537	0.859944	10.951613	1.136929	1.01875	0.776453	0.7366	0.653846	0.711569	0.565625	0.444444	0.519355	0.896721	0.916667	0.985646	1.237482	1.230643	1.210031
Malonate	0.150769	0.116667	0.0977	0.0722	0.0473	0.0699	0.066	0.0779	0.0784	0.410898	0.11622	0.102228	0.155102	0.0719	0.12979	0.0581	0.0525	0.06	0.0466	0.0455	0.0449	0.0595	0.0574	0.0549	0.0579	0.15125	0.183333	0.15	0.1	0.204286	0.0743	0.0617	0.0571	0.065	0.0667	0.773913	0.33625	0.192254	0.154306	0.180837	0.115816	0.205	0.145	0.121429	0.115	0.105	0.0571	0.05875	0.0625	0.0725	0.0478	0.0476	0.0465	0.0401	0.0497	0.0496	0.0472	0.049	0.0381	0.0326	0.357143	0.436667	0.29	0.435	0.184286	0.0778	0.168333	0.117143	0.0829	0.09375	0.0595	0.088	0.134615	0.0516	0.0647	0.0556	0.0643	0.0493	0.0713	0.0537	0.130719	0.111285	0.11293	0.11039	0.0819	0.0656	0.0561	0.0585	0.0622	0.0694	0.0728	1.16129	0.102351	0.114063	0.120715	0.136294	0.107427	0.144216	0.135938	0.13242	0.140323	0.142623	0.102339	0.105263	0.093	0.089	0.0502
Methionine	0.0923	0.0861	0.0988	0.0681	0.0554	0.0767	0.0787	0.0883	0.0757	0.0574	0.0345	0.0419	0.0599	0.0647	0.047	0.0549	0.0772	0.0697	0.0449	0.0309	0.0817	0.120501	0.0787	0.0895	0.109756	0.0825	0.0833	0.0933	0.0833	0.11	0.0814	0.07	0.0743	0.0933	0.105	0.042	0.05125	0.065	0.100478	0.0634	0.0511	0.085	0.065	0.07	0.0625	0.0625	0.0857	0.0875	0.05125	0.1	0.0833	0.0889	0.100775	0.0801	0.0877	0.0744	0.0814	0.0784	0.0978	0.0799	0.0529	0.0917	0.0817	0.07	0.0557	0.0678	0.0783	0.0557	0.0629	0.05	0.0291	0.044	0.0296	0.0321	0.0528	0.0657	0.0719	0.0753	0.0744	0.244764	0.0719	0.069	0.0556	0.0487	0.0819	0.0967	0.110774	0.0823	0.137161	0.0864	0.077	0.709677	0.0719	0.0609	0.0596	0.0582	0.0796	0.0745	0.0672	0.0563	0.0565	0.0574	0.0643	0.0558	0.0472	0.0626	0.0533
NAD+	0.0738	0.075	0.0907	0.106944	0.110811	0.149315	0.155319	0.162338	0.232432	0.458027	0.475096	0.433814	0.712925	0.644604	0.609394	0.483516	0.336617	0.444084	0.472546	0.461789	0.479167	0.544601	0.470492	0.456829	0.452744	0.09875	0.111667	0.12	0.095	0.195714	0.127143	0.106667	0.265714	0.308333	0.145	0.482609	0.59125	0.520055	0.572967	0.538462	0.62142	0.125	0.29125	0.217143	0.22125	0.22125	0.222857	0.38875	0.285	0.32375	0.732222	0.246032	0.423256	0.354167	0.418874	0.575194	0.397394	0.423203	0.441128	0.305057	0.0886	0.101667	0.108333	0.148333	0.115714	0.156667	0.138333	0.201429	0.215714	0.23875	0.481481	0.721863	0.390533	0.655509	0.701439	0.756005	0.74401	0.769863	0.817906	0.647906	0.539216	0.545455	0.487725	0.527597	0.431496	0.483607	0.590288	0.639241	0.400319	0.501543	0.341737	4.016129	0.387275	0.4	0.47541	0.433384	0.523873	0.469097	0.446875	0.348554	0.403226	0.454098	0.483918	0.389155	0.377682	0.439868	0.426332
NADP+	0.0538	0.0486	0.0512	0.0694	0.0486	0.074	0.066	0.0662	0.073	0.122239	0.113665	0.097	0.17415	0.14964	0.128554	0.174254	0.157635	0.176661	0.18802	0.18374	0.174679	0.181534	0.165574	0.166405	0.161585	0.06625	0.065	0.0783	0.065	0.0857	0.0657	0.065	0.108571	0.14	0.08	0.217391	0.2475	0.230982	0.228469	0.210526	0.251557	0.0817	0.0975	0.0914	0.10125	0.10125	0.0757	0.1125	0.1	0.1325	0.174444	0.111111	0.139535	0.13141	0.149007	0.156589	0.131922	0.153595	0.160862	0.115824	0.07	0.08	0.101667	0.0983	0.0829	0.112222	0.0883	0.0986	0.0914	0.0975	0.12037	0.164295	0.0902	0.153417	0.147482	0.145386	0.136192	0.175342	0.186646	0.137435	0.174837	0.159875	0.184943	0.154221	0.165354	0.152459	0.147193	0.183544	0.172249	0.140432	0.130252	1.83871	0.165975	0.160938	0.172876	0.151608	0.19496	0.160063	0.157813	0.111111	0.15	0.165574	0.147661	0.143541	0.147353	0.158155	0.094
Niacinamide	0.798462	0.822222	0.674419	0.713889	0.495946	0.647945	0.589362	0.503896	0.493243	0.340206	0.173691	0.158585	0.214966	0.258993	0.222497	0.326531	0.428571	0.398703	0.415973	0.396748	0.267628	0.312989	0.370492	0.346939	0.341463	0.71125	0.778333	0.94	0.738333	0.641429	0.542857	0.523333	0.53	0.61	0.916667	0.175362	0.28125	0.355463	0.288278	0.268556	0.342466	0.83	0.68125	0.77	0.69875	0.69875	0.665714	0.63375	0.48875	0.6625	0.452222	0.330159	0.350388	0.405449	0.379139	0.316279	0.350163	0.305556	0.351575	0.422512	0.728571	0.66	0.623333	0.503333	0.66	0.68	0.398333	0.39	0.465714	0.45625	0.321429	0.451488	0.133136	0.242678	0.398082	0.283186	0.282472	0.306849	0.314112	0.34555	0.477124	0.304075	0.414075	0.248377	0.305512	0.470492	0.314112	0.286392	0.435407	0.305556	0.294118	3.596774	0.362379	0.378125	0.38152	0.295559	0.314324	0.383518	0.35625	0.273973	0.275806	0.240984	0.263158	0.266348	0.30186	0.341021	0.278997
O-Acetylcarnitine	0.0815	0.0333	0.0349	0.0514	0.0351	0.0438	0.0362	0.0429	0.0365	0.110457	0.146871	0.131062	0.144218	0.0921	0.0742	0.0879	0.0673	0.0567	0.106489	0.130081	0.0288	0.0266	0.0557	0.0345	0.0335	0.0425	0.0683	0.065	0.08	0.0514	0.0514	0.05	0.0429	0.0817	0.0333	0.0768	0.12125	0.123098	0.0658	0.0985	0.0722	0.0933	0.05125	0.0657	0.07125	0.0725	0.0314	0.055	0.08875	0.085	0.104444	0.236508	0.244961	0.237179	0.231788	0.217054	0.159609	0.199346	0.197347	0.138662	0.11	0.075	0.11	0.103333	0.0971	0.05	0.05	0.09	0.0871	0.08375	0.17328	0.248383	0.119822	0.195258	0.196643	0.184576	0.126103	0.178082	0.171472	0.157068	0.253268	0.233542	0.276596	0.198052	0.23937	0.209836	0.185129	0.0554	0.0702	0.146605	0.0854	2.016129	0.172891	0.264063	0.242921	0.211332	0.238727	0.122029	0.132813	0.149163	0.158065	0.22623	0.171053	0.199362	0.188841	0.205931	0.144201
O-Phosphocholine	2.258462	2.016667	1.554651	1.347222	1.205405	1.686301	1.671277	1.823377	1.998649	1.587629	1.218391	1.087811	1.514286	1.214388	1.12979	0.544741	0.469622	0.557536	0.497504	0.708943	0.637821	0.643192	0.806557	0.77237	0.554878	0.3925	0.36	0.421667	0.341667	0.4	0.52	0.47	0.5	0.535	0.408333	0.455072	0.4075	0.320885	0.325359	0.300945	0.277709	1.483333	1.45875	1.515714	1.2225	1.2225	0.768571	1.20625	1.0675	1.06625	1.208889	2.057143	2.017054	1.916667	1.763245	1.812403	1.529316	2.055556	1.638474	1.65416	3.871429	3.053333	3.351667	3.135	2.634286	0.404444	1.993333	2.231429	2.41	2.635	1.425926	2.653299	1.047337	1.715481	2.405276	1.34134	1.547289	1.790411	1.921093	1.616492	1.689542	1.512539	2.220949	1.475649	2.508661	1.529508	1.261002	1.281646	1.499203	1.140432	1.969188	55.967742	4.713693	4.415625	5.131148	5.303216	5.722812	1.950872	4.426563	3.56621	4.86129	4.796721	4.277778	4.539075	4.985694	5.108731	3.183386
Ornithine	0.18	0.0694	0.110465	0.122222	0.12027	0.163014	0.218085	0.105195	0.224324	0.104566	0.046	0.140236	0.129252	0.107914	0.123609	0.133438	0.210181	0.175041	0.104825	0.121951	0.185897	0.358372	0.244262	0.22606	0.278963	0.07125	0.101667	0.163333	0.113333	0.168571	0.172857	0.173333	0.142857	0.18	0.23	0.123188	0.0875	0.102351	0.141148	0.180837	0.119552	0.243333	0.15125	0.157143	0.135	0.13	0.197143	0.22625	0.17	0.195	0.14	0.150794	0.141085	0.142628	0.162252	0.124031	0.14658	0.173203	0.126036	0.127243	0.137143	0.16	0.136667	0.188333	0.114286	0.155556	0.181667	0.181429	0.108571	0.11125	0.0701	0.139715	0.0666	0.0865	0.109113	0.108723	0.216898	0.19863	0.192716	0.235602	0.178105	0.148903	0.1473	0.142857	0.173228	0.185246	0.194234	0.259494	0.242424	0.20679	0.536415	2.451613	0.29184	0.204688	0.216095	0.326187	0.297082	0.160063	0.220313	0.188737	0.208065	0.178689	0.124269	0.15949	0.16309	0.199341	0.18652
Oxypurinol	9.578462	2.204167	2.381395	2.479167	1.616216	3.964384	2.021277	3.377922	3.825676	1.804124	1.933589	1.44692	2.378231	1.374101	2.737948	2.828885	3.254516	3.147488	3.231281	3.157724	3.519231	3.43662	4.944262	4.458399	4.536585	7.32125	2.735	4.03	6.983333	3.365714	3.99	4.051667	3.748571	5.27	4.915	2.415942	2.09625	3.103734	3.545455	3.611336	3.882939	5.125	3.4875	3.502857	3.12875	3.12875	3.921429	4.55	3.79875	5.87875	5.228889	3.31746	3.665116	4.474359	3.594371	3.863566	4.959283	4.426471	4.257048	4.71615	4.282857	5.476667	4.118333	4.225	3.734286	4.143333	4.008333	3.888571	3.412857	3.8525	1.218254	2.712807	1.192308	2.351464	2.459233	2.883692	3.791929	3.771233	5.047041	3.689791	4.97549	3.159875	5.576105	3.272727	4.72126	4.914754	5.626707	5.311709	6.266348	6.217593	1.802521	35.806452	3.070539	5.107813	5.278689	4.646248	3.534483	5.123613	5.6375	4.523592	5.141935	4.259016	4.323099	4.266348	4.194564	4.126853	3.899687
Phenylalanine	0.103077	0.0931	0.0779	0.0806	0.0622	0.10137	0.0989	0.0818	0.0959	0.0987	0.114943	0.0878	0.104762	0.0964	0.0828	0.10675	0.0887	0.121556	0.0765	0.0748	0.0737	0.131455	0.0951	0.0911	0.118902	0.1075	0.11	0.11	0.11	0.122857	0.0943	0.1	0.0957	0.1	0.158333	0.107246	0.0925	0.0705	0.145933	0.147099	0.115816	0.155	0.1	0.125714	0.11125	0.11125	0.135714	0.145	0.08625	0.12375	0.0978	0.0794	0.0791	0.0801	0.0778	0.0589	0.105863	0.102941	0.0896	0.0946	0.0757	0.0717	0.09	0.0817	0.07	0.0722	0.1	0.0829	0.0743	0.0675	0.0886	0.0893	0.0281	0.0753	0.0743	0.0847	0.0845	0.0918	0.121396	0.0877	0.135621	0.094	0.0933	0.0812	0.085	0.154098	0.16085	0.143987	0.148325	0.155864	0.163866	1.467742	0.138313	0.11875	0.123696	0.128637	0.119363	0.0713	0.115625	0.101979	0.104839	0.0902	0.0746	0.0813	0.0758	0.084	0.0846
Pyruvate	0.146154	0.147222	0.0174	0.102778	0.217568	0.00959	0.215957	0.248052	0.297297	0.0486	0.0524	0.0301	0.0449	0.046	0.0494	0.0298	0.0263	0.0227	0.0233	0.0195	0.0176	0.0282	0.0246	0.0361	0.0274	0.04375	0.0267	0.02	0.035	0.0714	0.0357	0.04	0.0486	0.0567	0.0967	0.029	0.01875	0.0235	0.0215	0.0148	0.0336	0.0683	0.08	0.0529	0.0925	0.09125	0.0457	0.135	0.09125	0.08625	0.101111	0.0365	0.0403	0.0449	0.0381	0.0341	0.0456	0.0408	0.0398	0.0375	0.0229	0.0433	0.0633	0.065	0.0486	0.0778	0.116667	0.1	0.112857	0.1	0.0251	0.0362	0.0636	0.0293	0.036	0.0417	0.0404	0.026	0.0607	0.0249	0.049	0.0408	0.0393	0.0373	0.0346	0.0672	0.0577	0.0348	0.0463	0.0401	0.0266	0.306452	0.0664	0.0422	0.0417	0.0536	0.0371	0.0571	0.040625	0.0396	0.0387	0.0393	0.0424	0.0415	0.0372	0.0593	0.0643
Sarcosine	0.149231	0.0986	0.119767	0.0917	0.0811	0.0808	0.0745	0.074	0.116216	0.0707	0.0562	0.0695	0.0585	0.0863	0.0742	0.0392	0.0493	0.06	0.0133	0.039	0.0657	0.0892	0.0721	0.0691	0.0671	0.00875	0.00833	0.0167	0.00667	0.01	0.0329	0.03	0.0286	0.055	0.0767	0.0101	0.0125	0.0124	0.0311	0.0769	0.056	0.0667	0.065	0.0714	0.04625	0.04625	0.0929	0.17625	0.09875	0.08375	0.0944	0.0714	0.0744	0.0769	0.0464	0.0744	0.0977	0.0931	0.0846	0.0669	0.0314	0.055	0.03	0.0233	0.0286	0.0489	0.0367	0.0371	0.0714	0.08875	0.0397	0.0621	0.0178	0.0307	0.0731	0.0746	0.14628	0.163014	0.163885	0.204188	0.0474	0.0455	0.0344	0.0422	0.0409	0.0902	0.0319	0.115506	0.113238	0.12963	0.063	0.725806	0.0207	0.040625	0.0596	0.0704	0.0517	0.0777	0.0484	0.0472	0.0274	0.0213	0.019	0.0207	0.0258	0.0297	0.0141
Succinate	0.0477	0.0319	0.0326	0.0222	0.0243	0.0288	0.0755	0.0247	0.0676	0.60972	0.623244	0.917431	1.034014	0.917986	1.039555	0.464678	0.108374	0.179903	0.279534	0.213008	0.38141	0.107981	0.0754	0.281005	0.189024	0.03	0.025	0.0383	0.03	0.0529	0.0186	0.02	0.07	0.0683	0.06	0.766667	0.33	0.467497	0.83134	0.676113	0.945205	0.0483	0.04625	0.0343	0.05	0.05	0.0843	0.0925	0.18375	0.24125	0.233333	0.226984	0.627907	0.209936	0.248344	0.232558	0.405537	0.264706	0.311774	0.12398	0.0357	0.0483	0.0333	0.04	0.0457	0.0789	0.0867	0.111429	0.108571	0.1525	0.547619	1.386805	0.551775	0.672245	1.51199	1.10493	1.306431	1.093151	1.050076	0.795812	0.488562	0.424765	0.207856	0.910714	0.130709	0.22623	0.192716	0.441456	0.253589	0.29784	0.885154	10.193548	0.720609	0.410938	0.241431	0.327718	0.392573	0.415214	0.26875	0.123288	0.209677	0.236066	0.210526	0.186603	0.257511	0.247117	0.208464
Taurine	13.278462	13.091667	10.568605	11.597222	6.82973	7.569863	8.467021	9.268831	10.683784	9.159057	10.639847	10.423329	9.718367	4.923741	6.877627	15.139717	13.694581	15.779579	14.916805	16.521951	9.886218	8.328638	13.419672	7.031397	8.567073	13.595	15.306667	22.758333	14.353333	18.675714	12.03	8.918333	11.937143	12.903333	6.645	17.134783	11.915	11.295989	7.722488	9.689609	6.684932	14.828333	13.35875	11.16	11.27	11.27	10.752857	11.005	7.84875	10.07	12.051111	13.290476	11.333333	11.923077	13.337748	11.565891	8.258958	11.379085	11.27529	10.079935	11.497143	13.581667	14.3	19.625	11.071429	7.848889	10.441667	9.775714	8.301429	6.75625	8.818783	10.4489	6.482249	7.101813	9.406475	6.795196	6.978562	8.553425	10.584219	7.856021	21.006536	16.769592	20.620295	15.561688	18.2	13.557377	10.664643	11.246835	15.870813	13.944444	7.253501	133.451613	8.630705	15.248438	17.456036	15.101072	15.356764	7.131537	11.404688	10.17656	11.914516	10.767213	10.741228	8.385965	7.522175	10.085667	9.045455
Trimethylamine	0.0215	0.0139	0.0337	0.0208	0.0135	0.0123	0.0117	0.0234	0.0135	0.00884	0.00766	0.0105	0.0068	0.00719	0.00618	0.0141	0.00821	0.0194	0.015	0.0244	0.00481	0.00626	0.00984	0.00785	0.00915	0.0175	0.0217	0.02	0.0117	0.01	0.00857	0.00833	0.00429	0.00667	0.01	0.0203	0.00875	0.00277	0.00359	0.00405	0.00374	0.01	0.00625	0.00714	0.005	0.005	0.00857	0.005	0.00625	0.0075	0.00889	0.019	0.0171	0.0208	0.0166	0.0155	0.0212	0.0147	0.0149	0.0147	0.0214	0.025	0.0317	0.0117	0.03	0.0256	0.01	0.0143	0.0143	0.0075	0.00794	0.00776	0.00296	0.00837	0.00719	0.00253	0.0113	0.00685	0.00455	0.00916	0.0245	0.0125	0.0131	0.013	0.0173	0.0262	0.0121	0.0174	0.0159	0.017	0.0056	0.0645	0.00553	0.003125	0.00298	0.00306	0.00133	0.0238	0.0109	0.00913	0.00323	0.00328	0.00292	0.00957	0.0143	0.0198	0.0141
Tryptophan	0.0554	0.05	0.0326	0.0431	0.0216	0.0452	0.0277	0.0273	0.0324	0.0486	0.0332	0.0262	0.049	0.0518	0.0321	0.0455	0.0312	0.0502	0.0416	0.0407	0.0337	0.0391	0.041	0.0251	0.0366	0.03125	0.0517	0.0267	0.04	0.0386	0.0329	0.04	0.0343	0.035	0.0433	0.0333	0.0325	0.0277	0.0359	0.0391	0.0311	0.0617	0.04	0.0557	0.03875	0.0525	0.0529	0.06	0.0425	0.0475	0.0289	0.0429	0.0186	0.0321	0.0348	0.0202	0.0342	0.0245	0.0315	0.0245	0.0371	0.0517	0.0367	0.0517	0.0343	0.0267	0.0467	0.0343	0.0343	0.0275	0.0357	0.0349	0.0104	0.0335	0.0468	0.0253	0.0252	0.0411	0.0349	0.0445	0.0621	0.0408	0.0409	0.039	0.0362	0.0459	0.0379	0.0364	0.0319	0.0571	0.0532	0.483871	0.0443	0.021875	0.0209	0.0168	0.0398	0.0317	0.0375	0.0365	0.0387	0.023	0.0205	0.0335	0.0386	0.0428	0.0596
Tyrosine	0.232308	0.158333	0.130233	0.131944	0.113514	0.182192	0.17234	0.146753	0.178378	0.129602	0.112388	0.10616	0.129252	0.12518	0.10754	0.11146	0.129721	0.139384	0.0948	0.0992	0.112179	0.186228	0.113115	0.0926	0.16311	0.135	0.165	0.136667	0.116667	0.147143	0.137143	0.106667	0.107143	0.135	0.195	0.156522	0.1025	0.103734	0.184211	0.159244	0.146949	0.163333	0.095	0.125714	0.1	0.1	0.172857	0.16	0.07	0.135	0.102222	0.0698	0.0729	0.0721	0.0646	0.0512	0.109121	0.0915	0.0896	0.101142	0.124286	0.146667	0.12	0.128333	0.118571	0.124444	0.156667	0.13	0.105714	0.11625	0.082	0.0776	0.0207	0.0697	0.0875	0.0759	0.0757	0.10411	0.122914	0.113874	0.106209	0.069	0.0573	0.0357	0.0535	0.147541	0.0531	0.148734	0.143541	0.160494	0.212885	1.322581	0.109267	0.0953	0.108793	0.130168	0.128647	0.120444	0.126563	0.13242	0.112903	0.0869	0.0556	0.0702	0.0701	0.0758	0.173981
UDP-N-Acetylglucosamine	0.210769	0.198611	0.180233	0.198611	0.174324	0.145205	0.215957	0.233766	0.236486	0.157585	0.186462	0.119266	0.24898	0.240288	0.211372	0.196232	0.155993	0.162075	0.212978	0.18374	0.149038	0.15493	0.186885	0.158556	0.202744	0.19125	0.16	0.17	0.158333	0.172857	0.185714	0.155	0.198571	0.201667	0.256667	0.12029	0.2425	0.141079	0.197368	0.161943	0.22665	0.188333	0.155	0.142857	0.1525	0.15625	0.155714	0.18	0.14375	0.25125	0.234444	0.219048	0.227907	0.240385	0.268212	0.206202	0.214984	0.23366	0.240464	0.241436	0.26	0.298333	0.301667	0.318333	0.277143	0.394444	0.288333	0.291429	0.302857	0.2825	0.148148	0.199224	0.0917	0.16318	0.193046	0.173198	0.210593	0.230137	0.235205	0.209424	0.310458	0.255486	0.324059	0.232143	0.250394	0.32623	0.245827	0.216772	0.271132	0.262346	0.207283	4.532258	0.253112	0.314063	0.28465	0.251149	0.350133	0.290016	0.290625	0.272451	0.285484	0.32623	0.30848	0.293461	0.323319	0.327842	0.369906
UDP-galactose	0.123077	0.104167	0.110465	0.119444	0.128378	0.163014	0.176596	0.167532	0.17973	0.0663	0.0575	0.0577	0.115646	0.095	0.0816	0.0848	0.0805	0.0859	0.0915	0.0862	0.0849	0.0829	0.0902	0.0612	0.0838	0.1175	0.106667	0.13	0.135	0.104286	0.105714	0.0917	0.125714	0.121667	0.136667	0.1	0.1	0.11065	0.147129	0.103914	0.117061	0.133333	0.1375	0.115714	0.1175	0.1175	0.154286	0.11875	0.1175	0.15125	0.126667	0.153968	0.0868	0.0897	0.160596	0.0853	0.169381	0.191176	0.162521	0.151713	0.152857	0.21	0.198333	0.178333	0.174286	0.234444	0.206667	0.164286	0.162857	0.18	0.140212	0.121604	0.0902	0.114365	0.105516	0.140329	0.174023	0.19589	0.118361	0.179319	0.147059	0.159875	0.160393	0.11039	0.15748	0.162295	0.157815	0.129747	0.175439	0.138889	0.028	1.451613	0.124481	0.167188	0.18927	0.119449	0.108753	0.152139	0.139063	0.135464	0.114516	0.116393	0.103801	0.103668	0.0959	0.110379	0.105016
UDP-glucose	0.0523	0.1375	0.103488	0.227778	0.187838	0.165753	0.376596	0.333766	0.367568	0.170839	0.148148	0.144168	0.472109	0.280576	0.241038	0.285714	0.210181	0.262561	0.336106	0.247154	0.269231	0.29108	0.286885	0.291994	0.291159	0.0875	0.19	0.201667	0.203333	0.205714	0.221429	0.183333	0.271429	0.323333	0.271667	0.0507	0.0225	0.107884	0.254785	0.134953	0.124533	0.388333	0.33875	0.282857	0.27125	0.22	0.41	0.37375	0.28375	0.4825	0.487778	0.290476	0.302326	0.283654	0.403974	0.308527	0.369707	0.558824	0.454395	0.473083	0.528571	0.486667	0.55	0.535	0.467143	0.575556	0.538333	0.511429	0.331429	0.47625	0.342593	0.408797	0.137574	0.25802	0.213429	0.351454	0.300126	0.508219	0.490137	0.388743	0.356209	0.382445	0.476268	0.352273	0.448819	0.519672	0.388467	0.329114	0.357257	0.300926	0.0546	2.419355	0.207469	0.259375	0.360656	0.194487	0.299735	0.530903	0.492188	0.455099	0.404839	0.429508	0.340643	0.314195	0.286123	0.377265	0.335423
UMP	0.152308	0.2625	0.22093	0.213889	0.266216	0.379452	0.340426	0.423377	0.444595	0.260677	0.206897	0.144168	0.35102	0.372662	0.320148	0.249608	0.175698	0.230146	0.269551	0.261789	0.373397	0.392801	0.429508	0.356358	0.394817	0.11625	0.128333	0.216667	0.123333	0.188571	0.371429	0.468333	0.341429	0.656667	0.578333	0.171014	0.23375	0.239281	0.357656	0.356275	0.37609	0.301667	0.28125	0.214286	0.25875	0.25875	0.451429	0.50125	0.46125	0.67125	0.673333	0.474603	0.404651	0.392628	0.438742	0.396899	0.498371	0.563725	0.585406	0.4323	0.322857	0.38	0.378333	0.335	0.352857	0.501111	0.453333	0.397143	0.387143	0.42	0.238095	0.353169	0.153846	0.260809	0.35012	0.461441	0.489281	0.483562	0.610015	0.465969	0.584967	0.539185	0.713584	0.517857	0.535433	0.67541	0.646434	0.602848	0.741627	0.634259	0.103641	4.306452	0.378976	0.81875	0.770492	0.640123	0.828912	0.499208	0.70625	0.631659	0.698387	0.793443	0.590643	0.586922	0.547926	0.607908	0.525078
Uracil	0.0431	0.0278	0.0221	0.0292	0.0122	0.00959	0.0149	0.0156	0.0108	0.0295	0.00766	0.0118	0.0381	0.0403	0.0272	0.0188	0.0197	0.0194	0.015	0.013	0.0272	0.0188	0.0197	0.0188	0.0305	0.03125	0.0533	0.05	0.0433	0.0471	0.03	0.0233	0.0457	0.0183	0.0217	0.0188	0.015	0.0194	0.0108	0.0054	0.00498	0.0583	0.03	0.0529	0.04125	0.04125	0.0543	0.0375	0.02875	0.03875	0.03	0.0159	0.0109	0.00641	0.00662	0.00465	0.00651	0.0114	0.0116	0.0114	0.03	0.0233	0.0367	0.02	0.0286	0.02	0.02	0.0171	0.0157	0.015	0.0198	0.0168	0.00296	0.0112	0.0168	0.0114	0.0126	0.0123	0.0121	0.0105	0.0196	0.0094	0.0262	0.0195	0.011	0.0197	0.0182	0.0174	0.0191	0.0139	0.0252	0.241935	0.0456	0.0172	0.0194	0.0858	0.0159	0.0254	0.0297	0.0365	0.0403	0.041	0.0205	0.0223	0.02	0.0231	0.058
Urea	11.726154	9.566667	15.888372	10.754167	8.413514	9.328767	11.887234	9.48961	11.182432	6.013255	4.547893	4.973788	9.091156	7.294964	7.448702	4.751962	5.042693	4.833063	5.680532	6.481301	6.080128	8.503912	6.306557	7.158556	6.324695	5.2875	7.738333	10.728333	4.3	7.941429	7.27	9.228333	8.422857	14.008333	11.121667	8.265217	5.35	12.033195	8.94378	6.072874	7.105853	5.613333	6.61375	7.01	6.7075	6.7075	10.56	8.52625	7.40375	8.5225	9.96	7.5	7.72093	6.839744	6.049669	8.11938	8.413681	6.112745	8.011609	6.141925	8.895714	10.053333	6.878333	10.47	7.952857	9.928889	7.213333	8.001429	7.208571	8.94375	7.189153	12.517464	4.946746	6.944212	8.97482	13.013906	15.636822	13.873973	12.007587	13.615183	7.681373	5.410658	6.756137	4.935065	7.143307	6.445902	6.133536	6.193038	7.411483	5.919753	27.915966	294.548387	28.565698	21.479688	20.415797	30.427259	30.730769	13.131537	17.048438	13.255708	21.280645	21.091803	10.302632	20.599681	15.749642	19.164745	19.594044
Uridine	0.812308	0.4875	0.402326	0.254167	0.359459	0.483562	0.358511	0.380519	0.335135	0.33137	0.190294	0.209699	0.217687	0.316547	0.333745	0.166405	0.147783	0.176661	0.211314	0.18374	0.141026	0.170579	0.140984	0.211931	0.185976	0.5225	0.458333	0.523333	0.483333	0.404286	0.364286	0.248333	0.29	0.3	0.561667	0.310145	0.4275	0.35408	0.36244	0.348178	0.425903	0.238333	0.21625	0.188571	0.28375	0.28375	0.285714	0.21	0.20375	0.22625	0.14	0.220635	0.254264	0.285256	0.221854	0.193798	0.211726	0.163399	0.150912	0.176183	0.354286	0.416667	0.378333	0.245	0.268571	0.31	0.266667	0.267143	0.312857	0.3225	0.248677	0.408797	0.147929	0.262204	0.438849	0.231353	0.261034	0.190411	0.262519	0.204188	0.607843	0.308777	0.307692	0.258117	0.310236	0.260656	0.197269	0.256329	0.328549	0.239198	0.123249	3.467742	0.33195	0.320313	0.327869	0.215926	0.213528	0.142631	0.28125	0.208524	0.220968	0.172131	0.241228	0.226475	0.281831	0.289951	0.34953
Valine	0.46	0.340278	0.30814	0.351389	0.25	0.339726	0.364894	0.319481	0.439189	0.353461	0.342273	0.259502	0.311565	0.248921	0.213844	0.350078	0.288998	0.34846	0.237937	0.23252	0.269231	0.532081	0.442623	0.340659	0.439024	0.26	0.266667	0.261667	0.22	0.282857	0.354286	0.298333	0.284286	0.32	0.461667	0.268116	0.1825	0.206086	0.389952	0.439946	0.30137	0.376667	0.2725	0.295714	0.2625	0.27	0.427143	0.475	0.26125	0.38	0.33	0.225397	0.248062	0.25641	0.198675	0.258915	0.35342	0.379085	0.305141	0.311582	0.252857	0.295	0.241667	0.275	0.214286	0.211111	0.306667	0.267143	0.202857	0.21	0.187831	0.25097	0.0962	0.164575	0.151079	0.199747	0.317781	0.249315	0.326252	0.289267	0.431373	0.319749	0.333879	0.25487	0.329134	0.431148	0.52352	0.579114	0.617225	0.526235	0.581232	6.935484	0.5574	0.517188	0.740686	0.856049	0.810345	0.272583	0.6	0.544901	0.627419	0.542623	0.331871	0.304625	0.377682	0.375618	0.467085
Xanthosine	0.0615	0.0111	0.0163	0.0167	0.0216	0.0233	0.0138	0.0169	0.0162	0.0177	0.0153	0.00917	0.0136	0.0158	0.0321	0.011	0.0115	0.0113	0.0116	0.00976	0.0112	0.011	0.0115	0.011	0.0107	0.015	0.01	0.00667	0.00833	0.00857	0.00429	0.01	0.00857	0.00667	0.0133	0.00435	0.00875	0.00692	0.00359	0.00945	0.00374	0.015	0.0075	0.0114	0.00625	0.00625	0.00571	0.0125	0.01	0.00625	0.0156	0.0111	0.0124	0.0112	0.00993	0.0109	0.0163	0.0131	0.0133	0.0163	0.0171	0.015	0.0183	0.00833	0.01	0.0167	0.01	0.0157	0.0157	0.0175	0.0132	0.0103	0.0133	0.00837	0.0252	0.00885	0.00883	0.00548	0.0152	0.00524	0.0131	0.0141	0.00818	0.00974	0.00945	0.0115	0.0106	0.0111	0.0112	0.017	0.0056	0.0484	0.0111	0.00469	0	0.0107	0.00928	0.00951	0.00625	0.00609	0.00645	0.00656	0.00585	0.00638	0.00572	0.00659	0.00627
NMR_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	KEGG Compound ID	PubChem Compound
3-Hydroxybutyrate	C01089	92135
3-Hydroxyisobutyrate	C01188	87
4-Hydroxybenzoate	C00156	135
ADP	C00008	6022
AMP	C00020	6083
ATP	C00002	5957
Acetate	C00033	176
Alanine	C00041	5950
Aspartate	C00049	5960
Benzoate	C00180	243
Betaine	C00719	248
Cadaverine	C01672	273
Carnitine	C00318	10917
Cholate	C00695	221493
Choline	C00114	305
Creatine	C00300	586
Dimethylamine	C00543	674
Formate	C00058	284
Fumarate	C00122	723
GTP	C00044	6830
Glucose	C00031	5793
Glutamate	C00025	33032
Glutamine	C00064	5961
Glutathione	C00051	124886
Glycerol	C00116	753
Glycine	C00037	750
Histidine	C00135	6274
IMP	C00130	8582
Inosine	C00294	6021
Isoleucine	C00407	6306
Lactate	C00186	107689
Leucine	C00123	6106
Lysine	C00047	5962
Malate	C00711	525
Malonate	C00383	867
Methionine	C00073	6137
NAD+	C00003	5893
NADP+	C00006	5886
Niacinamide	C00153	936
O-Acetylcarnitine	C02571	18230
O-Phosphocholine	C00588	1014
Ornithine	C00077	6262
Oxypurinol	C07599	4644
Phenylalanine	C00079	6140
Pyruvate	C00022	1060
Sarcosine	C00213	1088
Succinate	C00042	1110
Taurine	C00245	1123
Trimethylamine	C00565	1146
Tryptophan	C00078	6305
Tyrosine	C00082	6057
UDP-N-Acetylglucosamine	C00043	445675
UDP-galactose	C00052	18068
UDP-glucose	C00029	8629
UMP	C00105	6030
Uracil	C00106	1174
Urea	C00086	1176
Uridine	C00299	6029
Valine	C00183	6287
Xanthosine	C01762	64959
METABOLITES_END
#END