#METABOLOMICS WORKBENCH araskind_20210611_105341 DATATRACK_ID:2683 STUDY_ID:ST001828 ANALYSIS_ID:AN002966 PROJECT_ID:PR001155 VERSION 1 CREATED_ON June 14, 2021, 3:05 pm #PROJECT PR:PROJECT_SUMMARY Preterm birth is the leading cause of infant mortality worldwide, and also PR:PROJECT_SUMMARY greatly increases the risk of developing serious health complications in PR:PROJECT_SUMMARY childhood and throughout life. Conditions that contribute to preterm birth PR:PROJECT_SUMMARY remain largely unclear, though an influence by environmental exposures is PR:PROJECT_SUMMARY suspected but poorly understood. In our preliminary work, we found that exposure PR:PROJECT_SUMMARY to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to PR:PROJECT_SUMMARY this serious but understudied public health problem. We also observed strong PR:PROJECT_SUMMARY associations between phthalates/BPA and general markers of oxidative stress, and PR:PROJECT_SUMMARY in turn between these general markers of oxidative stress and risk of preterm PR:PROJECT_SUMMARY birth. In this nested case-control study within an ongoing cohort of pregnant PR:PROJECT_SUMMARY women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well PR:PROJECT_SUMMARY as levels of eicosanoids specific to arachidonic acid oxidation pathways, in PR:PROJECT_SUMMARY relation to both environmental exposures and preterm birth. PR:INSTITUTE University of Michigan PR:DEPARTMENT Nutritional Sciences PR:LABORATORY Meeker Lab PR:FIRST_NAME John PR:ADDRESS Ann Arbor, MI PR:EMAIL meekerj@umich.edu PR:PHONE 734-764-7184 PR:PROJECT_TITLE Nested case–control study of environmental exposure within the ongoing Puerto PR:PROJECT_TITLE Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort. PR:LAST_NAME Meeker #STUDY ST:STUDY_TITLE Nested case–control study of environmental exposure within the ongoing Puerto ST:STUDY_TITLE Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort. ST:STUDY_SUMMARY Preterm birth is the leading cause of infant mortality worldwide, and also ST:STUDY_SUMMARY greatly increases the risk of developing serious health complications in ST:STUDY_SUMMARY childhood and throughout life. Conditions that contribute to preterm birth ST:STUDY_SUMMARY remain largely unclear, though an influence by environmental exposures is ST:STUDY_SUMMARY suspected but poorly understood. In our preliminary work, we found that exposure ST:STUDY_SUMMARY to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to ST:STUDY_SUMMARY this serious but understudied public health problem. We also observed strong ST:STUDY_SUMMARY associations between phthalates/BPA and general markers of oxidative stress, and ST:STUDY_SUMMARY in turn between these general markers of oxidative stress and risk of preterm ST:STUDY_SUMMARY birth. In this nested case-control study within an ongoing cohort of pregnant ST:STUDY_SUMMARY women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well ST:STUDY_SUMMARY as levels of eicosanoids specific to arachidonic acid oxidation pathways, in ST:STUDY_SUMMARY relation to both environmental exposures and preterm birth. ST:INSTITUTE University of Michigan ST:DEPARTMENT MRC2 ST:LAST_NAME Kachman ST:FIRST_NAME Maureen ST:ADDRESS Ann Arbor, MI, 48105, USA ST:EMAIL mkachman@med.umich.edu ST:STUDY_TYPE Observational ST:PHONE 734-232-0842 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - Sample0002 PRETERM BIRTH:YES RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035268-P;20180810-EX00864-A003-IN0026-S00035268-N SUBJECT_SAMPLE_FACTORS - Sample1001 PRETERM BIRTH:NO RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035269-P;20180810-EX00864-A003-IN0026-S00035269-N SUBJECT_SAMPLE_FACTORS - Sample1006 PRETERM BIRTH:NO RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035270-P;20180810-EX00864-A003-IN0026-S00035270-N SUBJECT_SAMPLE_FACTORS - Sample1019 PRETERM BIRTH:YES RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035271-P;20180810-EX00864-A003-IN0026-S00035271-N SUBJECT_SAMPLE_FACTORS - 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Sample7128 PRETERM BIRTH:YES RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035354-P;20180810-EX00864-A003-IN0026-S00035354-N SUBJECT_SAMPLE_FACTORS - Sample7130 PRETERM BIRTH:NO RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035355-P;20180810-EX00864-A003-IN0026-S00035355-N SUBJECT_SAMPLE_FACTORS - Sample7138 PRETERM BIRTH:YES RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035361-P;20180810-EX00864-A003-IN0026-S00035361-N SUBJECT_SAMPLE_FACTORS - Sample7141 PRETERM BIRTH:YES RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035359-P;20180810-EX00864-A003-IN0026-S00035359-N SUBJECT_SAMPLE_FACTORS - Sample7148 PRETERM BIRTH:YES RAW_FILE_NAME=20180810-EX00864-A003-IN0026-S00035365-P;20180810-EX00864-A003-IN0026-S00035365-N #COLLECTION CO:COLLECTION_SUMMARY Standard blood plasma collection protocol CO:SAMPLE_TYPE Blood (plasma) CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY This is an observational study, no specific treatment was applied. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY MRC2 untargeted metabolomics sample preparation protocol SP:SAMPLEPREP_PROTOCOL_FILENAME Untargeted_metabolomics_analysis.DOC #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Negative mode RP CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1290 Infinity II CH:COLUMN_NAME Waters Acquity BEH C18 (100 x 2mm, 1.7um) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Agilent 6445 Q-TOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Negative mode untargeted analysis MS:MS_RESULTS_FILE ST001828_AN002966_Results.txt UNITS:Peak area Has m/z:Yes Has RT:Yes RT units:Minutes #END