#METABOLOMICS WORKBENCH DanielaWeber_22_20210810_072947 DATATRACK_ID:2793 STUDY_ID:ST001903 ANALYSIS_ID:AN003817 PROJECT_ID:PR001499 VERSION 1 CREATED_ON November 8, 2022, 11:35 am #PROJECT PR:PROJECT_TITLE Effect of ketogenic diet on the plasma and tumor metabolome of melanoma-bearing PR:PROJECT_TITLE mice PR:PROJECT_TYPE Metabolomics analysis PR:PROJECT_SUMMARY Growing evidence supports the use of low-carbohydrate/high-fat ketogenic diets PR:PROJECT_SUMMARY (KDs) together with standard therapies to improve cancer treatment outcomes. PR:PROJECT_SUMMARY However, conflicting data exist regarding the efficacy of KDs in melanoma, the PR:PROJECT_SUMMARY deadliest skin cancer. Here, we show that two different KD formulations PR:PROJECT_SUMMARY effectively reduced tumor growth in immunocompromised mice bearing genetically PR:PROJECT_SUMMARY and metabolically heterogeneous human melanoma xenografts. Furthermore, the KDs PR:PROJECT_SUMMARY exerted a metastasis-reducing effect in an immunocompetent syngeneic melanoma PR:PROJECT_SUMMARY mouse model. Ketone bodies did not directly influence melanoma cell PR:PROJECT_SUMMARY proliferation; therefore, we performed an in-depth metabolomics analysis using PR:PROJECT_SUMMARY the MxP® Quant 500 kit combined with a acylcarnitine assay (biocrates life PR:PROJECT_SUMMARY sciences ag)to elucidate potential antitumor mechanisms in vivo. Targeted PR:PROJECT_SUMMARY analysis of plasma and tumor metabolomes revealed distinct changes in amino acid PR:PROJECT_SUMMARY metabolism induced by the KDs. Moreover, the KDs increased sphingomyelin PR:PROJECT_SUMMARY synthesis and hydroxylation of certain lipids. Thus, KDs simultaneously affect PR:PROJECT_SUMMARY multiple metabolic pathways to create an unfavorable environment for melanoma PR:PROJECT_SUMMARY cell proliferation, supporting their potential as a complementary nutritional PR:PROJECT_SUMMARY approach to melanoma therapy. PR:INSTITUTE University Hospital of the Paracelsus Medical University Salzburg PR:LAST_NAME Weber PR:FIRST_NAME Daniela PR:ADDRESS Müllner Hauptstraße 48, Salzburg, Salzburg, 5020, Austria PR:EMAIL d.weber@salk.at PR:PHONE 0043 57255 26274 #STUDY ST:STUDY_TITLE Effect of ketogenic diet on the plasma and tumor metabolome of melanoma-bearing ST:STUDY_TITLE mice ST:STUDY_SUMMARY Growing evidence supports the use of low-carbohydrate/high-fat ketogenic diets ST:STUDY_SUMMARY (KDs) together with standard therapies to improve cancer treatment outcomes. ST:STUDY_SUMMARY However, conflicting data exist regarding the efficacy of KDs in melanoma, the ST:STUDY_SUMMARY deadliest skin cancer. Here, we show that two different KD formulations ST:STUDY_SUMMARY effectively reduced tumor growth in immunocompromised mice bearing genetically ST:STUDY_SUMMARY and metabolically heterogeneous human melanoma xenografts. Furthermore, the KDs ST:STUDY_SUMMARY exerted a metastasis-reducing effect in an immunocompetent syngeneic melanoma ST:STUDY_SUMMARY mouse model. Ketone bodies did not directly influence melanoma cell ST:STUDY_SUMMARY proliferation; therefore, we performed an in-depth metabolomics analysis using ST:STUDY_SUMMARY the MxP® Quant 500 kit combined with a acylcarnitine assay (biocrates life ST:STUDY_SUMMARY sciences ag)to elucidate potential anti-tumor mechanisms in vivo. Targeted ST:STUDY_SUMMARY analysis of plasma and tumor metabolomes revealed distinct changes in amino acid ST:STUDY_SUMMARY metabolism induced by the KDs. Moreover, the KDs increased sphingomyelin ST:STUDY_SUMMARY synthesis and hydroxylation of certain lipids. Thus, KDs simultaneously affect ST:STUDY_SUMMARY multiple metabolic pathways to create an unfavorable environment for melanoma ST:STUDY_SUMMARY cell proliferation, supporting their potential as a complementary nutritional ST:STUDY_SUMMARY approach to melanoma therapy. ST:INSTITUTE University Hospital of the Paracelsus Medical University Salzburg ST:LAST_NAME Weber ST:FIRST_NAME Daniela ST:ADDRESS Müllner Hauptstraße 48, 5020 Salzburg, Austria ST:EMAIL d.weber@salk.at ST:STUDY_TYPE Metabolomics analysis ST:PHONE 0043 57255 26274 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - plasma # 227 Sample description:A375 CTRL | Tissue:plasma RAW_FILE_NAME=1020494983 SUBJECT_SAMPLE_FACTORS - plasma # 228 Sample description:A375 CTRL | Tissue:plasma RAW_FILE_NAME=1020494998 SUBJECT_SAMPLE_FACTORS - plasma # 229 Sample description:A375 CTRL | Tissue:plasma RAW_FILE_NAME=1020497666 SUBJECT_SAMPLE_FACTORS - plasma # 230 Sample description:A375 CTRL | Tissue:plasma RAW_FILE_NAME=1020497671 SUBJECT_SAMPLE_FACTORS - plasma # 231 Sample description:A375 CTRL | Tissue:plasma RAW_FILE_NAME=1020497685 SUBJECT_SAMPLE_FACTORS - 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tumor # 62 Sample description:WM47 CTRL | Tissue:tumor RAW_FILE_NAME=1020491831 SUBJECT_SAMPLE_FACTORS - tumor # 63 Sample description:WM47 CTRL | Tissue:tumor RAW_FILE_NAME=1020491846 SUBJECT_SAMPLE_FACTORS - tumor # 64 Sample description:WM47 CTRL | Tissue:tumor RAW_FILE_NAME=1020491851 SUBJECT_SAMPLE_FACTORS - tumor # 65 Sample description:WM47 CTRL | Tissue:tumor RAW_FILE_NAME=1020491865 SUBJECT_SAMPLE_FACTORS - tumor # 66 Sample description:WM47 CTRL | Tissue:tumor RAW_FILE_NAME=1020491870 SUBJECT_SAMPLE_FACTORS - tumor # 67 Sample description:WM47 CTRL | Tissue:tumor RAW_FILE_NAME=1020491884 SUBJECT_SAMPLE_FACTORS - tumor # 68 Sample description:WM47 LCT | Tissue:tumor RAW_FILE_NAME=1020491899 SUBJECT_SAMPLE_FACTORS - tumor # 69 Sample description:WM47 LCT | Tissue:tumor RAW_FILE_NAME=1020491900 SUBJECT_SAMPLE_FACTORS - tumor # 71 Sample description:WM47 LCT | Tissue:tumor RAW_FILE_NAME=1020491929 SUBJECT_SAMPLE_FACTORS - tumor # 72 Sample description:WM47 LCT | Tissue:tumor RAW_FILE_NAME=1020491933 SUBJECT_SAMPLE_FACTORS - tumor # 74 Sample description:WM47 LCT | Tissue:tumor RAW_FILE_NAME=1020491952 SUBJECT_SAMPLE_FACTORS - tumor # 75 Sample description:WM47 LCT | Tissue:tumor RAW_FILE_NAME=1020491967 SUBJECT_SAMPLE_FACTORS - tumor # 77 Sample description:WM47 LCT | Tissue:tumor RAW_FILE_NAME=1020491986 SUBJECT_SAMPLE_FACTORS - tumor # 80 Sample description:WM47 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020492002 SUBJECT_SAMPLE_FACTORS - tumor # 81 Sample description:WM47 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020492017 SUBJECT_SAMPLE_FACTORS - tumor # 82 Sample description:WM47 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020492021 SUBJECT_SAMPLE_FACTORS - tumor # 84 Sample description:WM47 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020492041 SUBJECT_SAMPLE_FACTORS - tumor # 85 Sample description:WM47 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020492055 SUBJECT_SAMPLE_FACTORS - tumor # 86 Sample description:WM47 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020492060 SUBJECT_SAMPLE_FACTORS - tumor # 87 Sample description:WM47 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020492074 SUBJECT_SAMPLE_FACTORS - tumor # 14 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488737 SUBJECT_SAMPLE_FACTORS - tumor # 15 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488741 SUBJECT_SAMPLE_FACTORS - tumor # 16 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488756 SUBJECT_SAMPLE_FACTORS - tumor # 17 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488761 SUBJECT_SAMPLE_FACTORS - tumor # 18 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488775 SUBJECT_SAMPLE_FACTORS - tumor # 19 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488780 SUBJECT_SAMPLE_FACTORS - tumor # 21 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488805 SUBJECT_SAMPLE_FACTORS - tumor # 23 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488810 SUBJECT_SAMPLE_FACTORS - tumor # 24 Sample description:WM3311 CTRL | Tissue:tumor RAW_FILE_NAME=1020488824 SUBJECT_SAMPLE_FACTORS - tumor # 25 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488839 SUBJECT_SAMPLE_FACTORS - tumor # 26 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488843 SUBJECT_SAMPLE_FACTORS - tumor # 27 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488858 SUBJECT_SAMPLE_FACTORS - tumor # 28 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488862 SUBJECT_SAMPLE_FACTORS - tumor # 29 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488877 SUBJECT_SAMPLE_FACTORS - tumor # 30 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488896 SUBJECT_SAMPLE_FACTORS - tumor # 31 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488881 SUBJECT_SAMPLE_FACTORS - tumor # 33 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488907 SUBJECT_SAMPLE_FACTORS - tumor # 34 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488911 SUBJECT_SAMPLE_FACTORS - tumor # 35 Sample description:WM3311 LCT | Tissue:tumor RAW_FILE_NAME=1020488926 SUBJECT_SAMPLE_FACTORS - tumor # 47 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489033 SUBJECT_SAMPLE_FACTORS - tumor # 48 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489048 SUBJECT_SAMPLE_FACTORS - tumor # 49 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489052 SUBJECT_SAMPLE_FACTORS - tumor # 50 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489067 SUBJECT_SAMPLE_FACTORS - tumor # 52 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489071 SUBJECT_SAMPLE_FACTORS - tumor # 53 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489086 SUBJECT_SAMPLE_FACTORS - tumor # 54 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489091 SUBJECT_SAMPLE_FACTORS - tumor # 55 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020489101 SUBJECT_SAMPLE_FACTORS - tumor # 56 Sample description:WM3311 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020491778 SUBJECT_SAMPLE_FACTORS - tumor # 277 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020495294 SUBJECT_SAMPLE_FACTORS - tumor # 278 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020495305 SUBJECT_SAMPLE_FACTORS - tumor # 279 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020495310 SUBJECT_SAMPLE_FACTORS - tumor # 280 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020495324 SUBJECT_SAMPLE_FACTORS - tumor # 281 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020495339 SUBJECT_SAMPLE_FACTORS - tumor # 282 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020497995 SUBJECT_SAMPLE_FACTORS - tumor # 283 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020498007 SUBJECT_SAMPLE_FACTORS - tumor # 284 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020498011 SUBJECT_SAMPLE_FACTORS - tumor # 285 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020498026 SUBJECT_SAMPLE_FACTORS - tumor # 286 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020498031 SUBJECT_SAMPLE_FACTORS - tumor # 287 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020498045 SUBJECT_SAMPLE_FACTORS - tumor # 288 Sample description:WM3000 CTRL | Tissue:tumor RAW_FILE_NAME=1020498050 SUBJECT_SAMPLE_FACTORS - tumor # 289 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498064 SUBJECT_SAMPLE_FACTORS - tumor # 290 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498079 SUBJECT_SAMPLE_FACTORS - tumor # 291 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498083 SUBJECT_SAMPLE_FACTORS - tumor # 292 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498098 SUBJECT_SAMPLE_FACTORS - tumor # 293 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498109 SUBJECT_SAMPLE_FACTORS - tumor # 294 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498113 SUBJECT_SAMPLE_FACTORS - tumor # 295 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498128 SUBJECT_SAMPLE_FACTORS - tumor # 296 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498132 SUBJECT_SAMPLE_FACTORS - tumor # 297 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498147 SUBJECT_SAMPLE_FACTORS - tumor # 298 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498151 SUBJECT_SAMPLE_FACTORS - tumor # 299 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498166 SUBJECT_SAMPLE_FACTORS - tumor # 300 Sample description:WM3000 LCT | Tissue:tumor RAW_FILE_NAME=1020498171 SUBJECT_SAMPLE_FACTORS - tumor # 301 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020498185 SUBJECT_SAMPLE_FACTORS - tumor # 302 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020498190 SUBJECT_SAMPLE_FACTORS - tumor # 303 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020498201 SUBJECT_SAMPLE_FACTORS - tumor # 304 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020498215 SUBJECT_SAMPLE_FACTORS - tumor # 305 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020498220 SUBJECT_SAMPLE_FACTORS - tumor # 306 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020503583 SUBJECT_SAMPLE_FACTORS - tumor # 307 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020503598 SUBJECT_SAMPLE_FACTORS - tumor # 308 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020503609 SUBJECT_SAMPLE_FACTORS - tumor # 309 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020503613 SUBJECT_SAMPLE_FACTORS - tumor # 310 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020503628 SUBJECT_SAMPLE_FACTORS - tumor # 311 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020503632 SUBJECT_SAMPLE_FACTORS - tumor # 312 Sample description:WM3000 LCT-MCT | Tissue:tumor RAW_FILE_NAME=1020503647 #COLLECTION CO:COLLECTION_SUMMARY Human melanoma xenografts were established in mice using A375 and WM47 (BRAF CO:COLLECTION_SUMMARY mutant), WM3311 (BRAF/NRAS wild-type) and WM3000 (NRAS mutant) cells. Blood was CO:COLLECTION_SUMMARY taken by cardiac puncture, collected in heparin-coated tubes and centrifuged for CO:COLLECTION_SUMMARY 3 min at 2000 g. Plasma samples were stored at -80 °C until analysis. Tumors CO:COLLECTION_SUMMARY were harvested and snap frozen in liquid nitrogen and stored at -80°C for CO:COLLECTION_SUMMARY metabolomics. CO:SAMPLE_TYPE Blood (plasma) and tumor tissue #TREATMENT TR:TREATMENT_SUMMARY Human melanoma xenografts were established in mice using A375 and WM47 (BRAF TR:TREATMENT_SUMMARY mutant), WM3311 (BRAF/NRAS wild-type) and WM3000 (NRAS mutant) cells. Once the TR:TREATMENT_SUMMARY tumor volume reached 100 mm3, mice were equally assigned to control diet (CTRL) TR:TREATMENT_SUMMARY and two ketogenic diet (KDs) differing in their fat composition (LCT: long-chain TR:TREATMENT_SUMMARY triglyceride-based KD and LCT-MCT: long-chain triglyceride-based KD supplemented TR:TREATMENT_SUMMARY with C8 and C10 medium-chain triglycerides, ratio of fat to the sum of TR:TREATMENT_SUMMARY carbohydrate and protein of 8:1). Both KDs were administered ad libitum as TR:TREATMENT_SUMMARY monotherapy. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY To capture a broad spectrum of metabolites, we used the MxP® Quant 500 kit SP:SAMPLEPREP_SUMMARY combined with the in-house acylcarnitine (AC) assay (biocrates life sciences SP:SAMPLEPREP_SUMMARY ag). Samples were prepared the same way for both assays. Therefore, 50-80 mg of SP:SAMPLEPREP_SUMMARY tumor tissues were transferred to 0.5 ml Precellys® vials followed by the SP:SAMPLEPREP_SUMMARY addition of 85:15 ethanol:0.01 M phosphate as a lysis buffer with a volume [µl] SP:SAMPLEPREP_SUMMARY of 3 times the tissue weight [mg]. Tissue homogenization was carried out at 4 SP:SAMPLEPREP_SUMMARY °C and 5800 rpm using a Precellys® 24 homogenizer coupled to a Cryolys® SP:SAMPLEPREP_SUMMARY cooling unit. The homogenates were centrifuged at 10,000 g for 2 min at 2-4 °C. SP:SAMPLEPREP_SUMMARY Supernatants were collected and stored at -80 °C until analysis. Plasma samples SP:SAMPLEPREP_SUMMARY as well as tissue homogenate supernatant were thawed on ice, then vortexed SP:SAMPLEPREP_SUMMARY before use. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME Biocrates Acylcarnitine Column #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo TQS Vantage MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS MS acquisition data were obtained using MRM transition (Q1 and Q3 pair) in MS:MS_COMMENTS positive ion mode. Raw data files of the AC assay were generated by using MS:MS_COMMENTS XcaliburTM software (Thermo Fisher) and exported to MetIDQTM for further MS:MS_COMMENTS analysis, including peak integration, retention time correction, area MS:MS_COMMENTS calculation, calibration curve preparation and concentration calculation. MS:MS_COMMENTS Downstream analysis was performed using MetaboAnalyst 5.0. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS uM MS_METABOLITE_DATA_START Samples plasma # 14 plasma # 15 plasma # 16 plasma # 17 plasma # 18 plasma # 19 plasma # 21 plasma # 22 plasma # 227 plasma # 228 plasma # 229 plasma # 23 plasma # 230 plasma # 231 plasma # 232 plasma # 233 plasma # 234 plasma # 235 plasma # 236 plasma # 237 plasma # 238 plasma # 239 plasma # 24 plasma # 240 plasma # 241 plasma # 243 plasma # 244 plasma # 245 plasma # 246 plasma # 247 plasma # 248 plasma # 249 plasma # 25 plasma # 251 plasma # 252 plasma # 253 plasma # 254 plasma # 255 plasma # 256 plasma # 257 plasma # 258 plasma # 259 plasma # 26 plasma # 261 plasma # 262 plasma # 263 plasma # 27 plasma # 277 plasma # 278 plasma # 279 plasma # 28 plasma # 280 plasma # 281 plasma # 282 plasma # 283 plasma # 284 plasma # 285 plasma # 286 plasma # 287 plasma # 288 plasma # 289 plasma # 29 plasma # 290 plasma # 291 plasma # 292 plasma # 293 plasma # 294 plasma # 295 plasma # 296 plasma # 297 plasma # 298 plasma # 299 plasma # 30 plasma # 300 plasma # 301 plasma # 302 plasma # 303 plasma # 304 plasma # 305 plasma # 306 plasma # 307 plasma # 308 plasma # 309 plasma # 31 plasma # 310 plasma # 311 plasma # 312 plasma # 32 plasma # 33 plasma # 34 plasma # 35 plasma # 47 plasma # 48 plasma # 49 plasma # 50 plasma # 51 plasma # 52 plasma # 53 plasma # 54 plasma # 55 plasma # 56 plasma # 58 plasma # 59 plasma # 60 plasma # 61 plasma # 62 plasma # 63 plasma # 64 plasma # 65 plasma # 66 plasma # 67 plasma # 68 plasma # 69 plasma # 71 plasma # 72 plasma # 74 plasma # 75 plasma # 77 plasma # 80 plasma # 81 plasma # 82 plasma # 84 plasma # 85 plasma # 86 plasma # 87 tumor # 14 tumor # 15 tumor # 16 tumor # 17 tumor # 18 tumor # 19 tumor # 21 tumor # 227 tumor # 228 tumor # 229 tumor # 23 tumor # 230 tumor # 231 tumor # 232 tumor # 233 tumor # 234 tumor # 235 tumor # 236 tumor # 237 tumor # 238 tumor # 239 tumor # 24 tumor # 240 tumor # 241 tumor # 243 tumor # 244 tumor # 245 tumor # 246 tumor # 247 tumor # 248 tumor # 249 tumor # 25 tumor # 250 tumor # 251 tumor # 252 tumor # 253 tumor # 254 tumor # 255 tumor # 256 tumor # 257 tumor # 258 tumor # 259 tumor # 26 tumor # 261 tumor # 262 tumor # 263 tumor # 27 tumor # 277 tumor # 278 tumor # 279 tumor # 28 tumor # 280 tumor # 281 tumor # 282 tumor # 283 tumor # 284 tumor # 285 tumor # 286 tumor # 287 tumor # 288 tumor # 289 tumor # 29 tumor # 290 tumor # 291 tumor # 292 tumor # 293 tumor # 294 tumor # 295 tumor # 296 tumor # 297 tumor # 298 tumor # 299 tumor # 30 tumor # 300 tumor # 301 tumor # 302 tumor # 303 tumor # 304 tumor # 305 tumor # 306 tumor # 307 tumor # 308 tumor # 309 tumor # 31 tumor # 310 tumor # 311 tumor # 312 tumor # 33 tumor # 34 tumor # 35 tumor # 47 tumor # 48 tumor # 49 tumor # 50 tumor # 52 tumor # 53 tumor # 54 tumor # 55 tumor # 56 tumor # 58 tumor # 59 tumor # 60 tumor # 61 tumor # 62 tumor # 63 tumor # 64 tumor # 65 tumor # 66 tumor # 67 tumor # 68 tumor # 69 tumor # 71 tumor # 72 tumor # 74 tumor # 75 tumor # 77 tumor # 80 tumor # 81 tumor # 82 tumor # 84 tumor # 85 tumor # 86 tumor # 87 Factors Sample description:WM3311 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:A375 CTRL | Tissue:plasma Sample description:WM3311 CTRL | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:A375 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 CTRL | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3000 LCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3000 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3311 LCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM3311 LCT-MCT | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 CTRL | Tissue:plasma Sample description:WM47 LCT | Tissue:plasma Sample description:WM47 LCT | Tissue:plasma Sample description:WM47 LCT | Tissue:plasma Sample description:WM47 LCT | Tissue:plasma Sample description:WM47 LCT | Tissue:plasma Sample description:WM47 LCT | Tissue:plasma Sample description:WM47 LCT | Tissue:plasma Sample description:WM47 LCT-MCT | Tissue:plasma Sample description:WM47 LCT-MCT | Tissue:plasma Sample description:WM47 LCT-MCT | Tissue:plasma Sample description:WM47 LCT-MCT | Tissue:plasma Sample description:WM47 LCT-MCT | Tissue:plasma Sample description:WM47 LCT-MCT | Tissue:plasma Sample description:WM47 LCT-MCT | Tissue:plasma Sample description:WM3311 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:A375 CTRL | Tissue:tumor Sample description:WM3311 CTRL | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:A375 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 CTRL | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3000 LCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3000 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3311 LCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM3311 LCT-MCT | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 CTRL | Tissue:tumor Sample description:WM47 LCT | Tissue:tumor Sample description:WM47 LCT | Tissue:tumor Sample description:WM47 LCT | Tissue:tumor Sample description:WM47 LCT | Tissue:tumor Sample description:WM47 LCT | Tissue:tumor Sample description:WM47 LCT | Tissue:tumor Sample description:WM47 LCT | Tissue:tumor Sample description:WM47 LCT-MCT | Tissue:tumor Sample description:WM47 LCT-MCT | Tissue:tumor Sample description:WM47 LCT-MCT | Tissue:tumor Sample description:WM47 LCT-MCT | Tissue:tumor Sample description:WM47 LCT-MCT | Tissue:tumor Sample description:WM47 LCT-MCT | Tissue:tumor Sample description:WM47 LCT-MCT | Tissue:tumor C4-2M 0.153 0.14 0.121 0.177 0.103 0.121 0.114 0.105 0.156 0.09 0.104 0.187 0.126 0.084 0.084 0.113 0.077 0.097 0.096 0.1 0.106 0.104 0.105 0.062 0.066 0.105 0.099 0.114 0.061 0.069 0.088 0.07 0.21 0.064 0.084 0.098 0.099 0.1 0.041 0.111 0.151 0.069 0.078 0.15 0.123 0.102 0.055 0.084 0.05 0.095 0.164 0.042 0.129 0.045 0.071 0.101 0.057 0.074 0.073 0.059 0.058 0.049 0.045 0.04 0.051 0.035 0.032 0.07 0.047 0.066 0.048 0.034 0.066 0.062 0.162 0.122 0.073 0.073 0.094 0.098 0.083 0.163 0.112 0.079 0.115 0.099 0.073 0.055 0.043 0.077 0.075 0.08 0.056 0.11 0.101 0.151 0.115 0.069 0.141 0.108 0.061 0.221 0.17 0.184 0.258 0.086 0.205 0.178 0.104 0.164 0.185 0.067 0.079 0.109 0.105 0.074 0.091 0.13 0.176 0.129 0.034 0.178 0.111 0.12 0.316 1.56 1.43 0.976 0.975 0.901 0.591 1.5 0.416 0.564 0.244 1.43 0.56 0.61 0.426 0.681 0.285 0.189 0.155 0.715 0.436 0.324 0.946 0.157 0.838 0.291 0.393 0.632 0.726 2.11 0.447 0.3 0.93 0.362 0.508 0.193 0.183 0.231 0.387 0.395 0.757 0.281 0.463 0.328 0.276 0.55 0.393 0.865 0.453 0.818 0.372 0.691 0.435 0.685 0.347 0.382 0.485 0.368 0.529 0.705 0.412 0.422 0.567 0.177 0.169 0.142 0.098 0.179 0.184 0.118 0.221 0.23 0.174 0.447 0.146 0.222 0.194 0.123 0.144 0.138 0.238 0.15 0.423 0.126 1.41 0.21 0.188 0.168 1.31 1.05 0.514 0.427 0.895 0.879 1.15 1.15 0.679 0.862 1.16 0.753 0.362 0.285 0.283 0.436 0.631 0.347 0.514 0.571 0.431 0.455 0.414 0.593 0.442 0.476 0.385 0.461 0.607 0.367 0.402 0.312 0.679 0.394 0.493 0.513 C8-DC 0.016 0.011 0.027 0.037 0.029 0.023 0.016 0.017 0.021 0.014 0.025 0.036 0.012 0.023 0.013 0.025 0.02 0.015 0.021 0.02 0.014 0.017 0.022 0.02 0.041 0.026 0.041 0.055 0.056 0.054 0.035 0.086 0.117 0.024 0.025 0.044 0.02 0.031 0.053 0.03 0.018 0.072 0.046 0.022 0.07 0.045 0.075 0.008 0.009 0.017 0.038 0.009 0.017 0.008 0.014 0.013 0.013 0.012 0.014 0.009 0.031 0.099 0.014 0.016 0.019 0.012 0.016 0.027 0.024 0.018 0.011 0.032 0.025 0.023 0.03 0.04 0.04 0.024 0.031 0.033 0.061 0.038 0.016 0.147 0.024 0.041 0.021 0.017 0.08 0.05 0.047 0.024 0.364 0.037 0.025 0.044 0.034 0.321 0.157 0.094 0.04 0.029 0.023 0.024 0.039 0.009 0.029 0.018 0.022 0.014 0.046 0.041 0.078 0.05 0.038 0.037 0.058 0.061 0.066 0.033 0.049 0.089 0.041 0.065 0.048 CAR 10:0 0.01 0.011 0.015 0.018 0.008 0.013 0.01 0.008 0.01 0.009 0.011 0.016 0.01 0.01 0.007 0.013 0.01 0.01 0.015 0.01 0.009 0.009 0.015 0.011 0.022 0.011 0.017 0.039 0.01 0.025 0.011 0.026 0.019 0.009 0.012 0.027 0.024 0.024 0.031 0.023 0.031 0.039 0.007 0.024 0.058 0.047 0.028 0.009 0.009 0.024 0.023 0.016 0.014 0.01 0.015 0.02 0.015 0.016 0.014 0.011 0.011 0.01 0.01 0.011 0.01 0.013 0.015 0.022 0.014 0.011 0.012 0.013 0.011 0.016 0.034 0.041 0.043 0.025 0.028 0.06 0.049 0.039 0.037 0.018 0.029 0.041 0.028 0.003 0.02 0.011 0.009 0.018 0.069 0.035 0.028 0.062 0.041 0.123 0.072 0.047 0.017 0.025 0.01 0.012 0.026 0.012 0.014 0.014 0.009 0.011 0.018 0.013 0.013 0.014 0.01 0.008 0.013 0.02 0.043 0.025 0.02 0.335 0.035 0.04 0.044 0.033 0.033 0.033 0.029 0.026 0.018 0.029 0.012 0.021 0.015 0.036 0.02 0.026 0.013 0.024 0.021 0.027 0.014 0.038 0.023 0.023 0.04 0.021 0.024 0.019 0.033 0.033 0.02 0.053 0.027 0.024 0.03 0.024 0.03 0.023 0.021 0.026 0.02 0.014 0.029 0.022 0.025 0.02 0.025 0.022 0.019 0.051 0.052 0.123 0.119 0.037 0.107 0.123 0.113 0.084 0.118 0.096 0.097 0.127 0.08 0.089 0.022 0.085 0.073 0.114 0.087 0.1 0.128 0.081 0.122 0.12 0.104 0.028 0.153 0.184 0.134 0.219 0.114 0.219 0.315 0.211 0.257 0.207 0.039 0.163 0.264 0.225 0.058 0.038 0.029 0.035 0.048 0.066 0.04 0.037 0.128 0.061 0.039 0.031 0.068 0.056 0.034 0.043 0.04 0.062 0.112 0.064 0.042 0.058 0.108 0.07 0.091 0.07 0.069 0.066 0.064 0.084 0.046 0.039 0.162 0.069 0.117 0.1 CAR 12:0 0.019 0.015 0.02 0.031 0.015 0.02 0.014 0.009 0.023 0.02 0.026 0.02 0.021 0.021 0.016 0.029 0.023 0.02 0.025 0.023 0.02 0.022 0.021 0.023 0.052 0.023 0.037 0.082 0.031 0.065 0.022 0.071 0.053 0.02 0.031 0.038 0.025 0.029 0.037 0.024 0.031 0.053 0.015 0.023 0.046 0.048 0.091 0.015 0.017 0.036 0.034 0.023 0.025 0.016 0.03 0.034 0.022 0.029 0.026 0.017 0.021 0.026 0.021 0.021 0.018 0.019 0.022 0.038 0.025 0.022 0.017 0.024 0.02 0.026 0.036 0.046 0.037 0.032 0.03 0.034 0.043 0.042 0.05 0.047 0.034 0.047 0.027 0.008 0.038 0.019 0.018 0.014 0.054 0.027 0.023 0.025 0.023 0.082 0.069 0.052 0.021 0.037 0.02 0.021 0.034 0.018 0.024 0.027 0.015 0.014 0.033 0.033 0.051 0.031 0.027 0.015 0.035 0.047 0.035 0.031 0.023 0.056 0.037 0.044 0.04 0.079 0.089 0.078 0.06 0.065 0.043 0.071 0.027 0.046 0.024 0.102 0.054 0.06 0.028 0.054 0.047 0.055 0.023 0.061 0.043 0.041 0.089 0.043 0.06 0.041 0.063 0.087 0.029 0.097 0.06 0.037 0.083 0.04 0.047 0.05 0.025 0.047 0.04 0.025 0.042 0.033 0.045 0.067 0.036 0.051 0.042 0.107 0.147 0.27 0.205 0.092 0.257 0.226 0.205 0.276 0.302 0.244 0.293 0.252 0.215 0.238 0.062 0.249 0.178 0.234 0.248 0.297 0.288 0.253 0.27 0.189 0.253 0.088 0.266 0.348 0.286 0.273 0.239 0.233 0.331 0.333 0.341 0.294 0.121 0.242 0.307 0.275 0.145 0.108 0.086 0.097 0.061 0.102 0.079 0.082 0.091 0.113 0.083 0.072 0.189 0.167 0.088 0.157 0.127 0.167 0.326 0.275 0.131 0.13 0.217 0.236 0.205 0.203 0.19 0.199 0.171 0.147 0.124 0.097 0.249 0.166 0.274 0.205 CAR 12:0;OH 0.006 0.004 0.007 0.01 0.005 0.008 0.005 0.004 0.005 0.004 0.006 0.003 0.004 0.005 0.003 0.007 0.005 0.004 0.005 0.005 0.004 0.005 0.009 0.006 0.016 0.006 0.01 0.02 0.006 0.022 0.006 0.02 0.02 0.005 0.005 0.008 0.006 0.006 0.012 0.007 0.008 0.013 0.003 0.005 0.014 0.009 0.038 0.003 0.003 0.006 0.013 0.003 0.005 0.003 0.006 0.006 0.005 0.005 0.004 0.003 0.004 0.011 0.004 0.004 0.003 0.004 0.003 0.006 0.004 0.003 0.003 0.004 0.006 0.005 0.008 0.008 0.007 0.006 0.006 0.006 0.006 0.007 0.007 0.016 0.006 0.009 0.005 0.003 0.017 0.011 0.006 0.006 0.018 0.009 0.008 0.006 0.006 0.029 0.024 0.022 0.005 0.013 0.006 0.004 0.01 0.005 0.007 0.007 0.004 0.005 0.008 0.011 0.012 0.01 0.007 0.004 0.011 0.014 0.011 0.008 0.005 0.011 0.013 0.012 0.013 0.013 0.013 0.017 0.011 0.008 0.009 0.01 0.013 0.015 0.009 0.011 0.012 0.014 0.009 0.014 0.012 0.018 0.007 0.015 0.01 0.013 0.014 0.013 0.016 0.01 0.013 0.024 0.012 0.018 0.02 0.015 0.023 0.009 0.011 0.01 0.007 0.017 0.011 0.011 0.011 0.008 0.012 0.011 0.007 0.016 0.012 0.096 0.029 0.03 0.045 0.018 0.033 0.036 0.028 0.061 0.038 0.036 0.041 0.039 0.022 0.04 0.01 0.038 0.05 0.039 0.032 0.049 0.047 0.046 0.038 0.039 0.043 0.02 0.048 0.058 0.036 0.056 0.032 0.044 0.07 0.044 0.049 0.034 0.026 0.051 0.048 0.05 0.034 0.018 0.021 0.015 0.028 0.023 0.015 0.015 0.055 0.029 0.017 0.014 0.036 0.027 0.022 0.044 0.027 0.038 0.045 0.054 0.042 0.037 0.061 0.071 0.071 0.094 0.077 0.07 0.082 0.056 0.056 0.061 0.061 0.062 0.055 0.049 CAR 14:0 0.052 0.045 0.079 0.094 0.066 0.057 0.042 0.042 0.068 0.062 0.089 0.056 0.061 0.089 0.053 0.095 0.078 0.068 0.079 0.074 0.07 0.071 0.071 0.083 0.143 0.073 0.104 0.18 0.086 0.17 0.074 0.214 0.15 0.064 0.081 0.094 0.063 0.077 0.102 0.065 0.068 0.122 0.052 0.062 0.109 0.108 0.222 0.042 0.043 0.083 0.091 0.052 0.058 0.044 0.072 0.072 0.053 0.079 0.06 0.045 0.061 0.091 0.064 0.063 0.055 0.051 0.062 0.101 0.061 0.065 0.042 0.072 0.06 0.069 0.077 0.09 0.098 0.07 0.066 0.066 0.106 0.076 0.089 0.132 0.073 0.096 0.052 0.043 0.121 0.061 0.062 0.04 0.172 0.059 0.054 0.057 0.062 0.213 0.141 0.127 0.054 0.086 0.062 0.053 0.07 0.055 0.072 0.071 0.061 0.042 0.085 0.091 0.151 0.084 0.08 0.059 0.107 0.109 0.077 0.068 0.057 0.085 0.074 0.091 0.079 0.426 0.467 0.361 0.3 0.359 0.239 0.375 0.134 0.246 0.109 0.666 0.23 0.268 0.158 0.283 0.202 0.264 0.112 0.254 0.149 0.189 0.517 0.181 0.337 0.196 0.263 0.366 0.132 0.407 0.197 0.148 0.401 0.159 0.17 0.234 0.114 0.189 0.151 0.141 0.161 0.135 0.162 0.366 0.122 0.223 0.174 0.573 0.489 0.889 0.618 0.434 0.811 0.681 0.639 0.802 1.06 0.779 1.17 0.798 0.921 0.723 0.365 0.768 0.602 0.621 0.74 0.988 0.776 0.732 0.804 0.53 0.76 0.465 0.675 0.908 0.957 0.706 0.714 0.623 0.815 0.954 0.907 0.82 0.602 0.619 0.708 0.688 0.67 0.41 0.373 0.57 0.328 0.499 0.391 0.355 0.482 0.477 0.529 0.418 0.733 0.603 0.445 0.8 0.638 0.754 1.18 1.25 0.635 0.554 0.658 0.95 0.719 0.804 0.608 0.766 0.642 0.564 0.478 0.489 0.837 0.606 1.15 0.767 CAR 16:0 0.153 0.13 0.238 0.233 0.187 0.155 0.14 0.131 0.217 0.205 0.253 0.164 0.204 0.224 0.139 0.247 0.237 0.175 0.239 0.218 0.184 0.19 0.202 0.267 0.399 0.25 0.314 0.64 0.283 0.44 0.274 0.485 0.47 0.229 0.3 0.305 0.23 0.259 0.303 0.209 0.22 0.35 0.198 0.198 0.276 0.344 0.609 0.154 0.137 0.223 0.259 0.154 0.181 0.129 0.22 0.204 0.166 0.229 0.172 0.155 0.234 0.29 0.26 0.253 0.233 0.202 0.23 0.33 0.237 0.252 0.185 0.256 0.19 0.229 0.219 0.292 0.311 0.238 0.23 0.222 0.291 0.24 0.302 0.395 0.237 0.291 0.21 0.183 0.422 0.194 0.209 0.127 0.407 0.162 0.153 0.172 0.164 0.473 0.401 0.346 0.181 0.242 0.172 0.172 0.202 0.163 0.196 0.17 0.184 0.12 0.221 0.285 0.361 0.235 0.238 0.187 0.282 0.266 0.188 0.195 0.184 0.24 0.199 0.237 0.199 1.31 1.65 1.19 0.987 1.11 0.798 1.25 0.745 1.32 0.604 2.21 1.38 1.39 0.877 1.39 1.09 1.59 0.744 1.29 0.778 1 1.58 0.751 1.42 1.2 1.41 1.87 0.681 1.51 0.906 0.746 1.51 0.766 0.7 1.12 0.658 0.83 0.898 0.812 0.84 0.707 0.814 1.19 0.596 1.18 1.08 2.44 2.09 4.09 2.19 1.72 3.59 2.41 2.6 3.38 4.67 3.47 4.82 2.86 5.39 3.21 1.4 3.49 2.5 2.29 3.82 4.37 2.94 3.03 3.1 2 3.51 1.66 2.09 4.04 4.15 2.48 3.64 2.41 2.94 4.17 3.36 3.43 1.82 2.25 2.82 2.29 2.27 1.31 1.63 2.08 1.07 1.78 1.28 1.44 1.75 1.56 1.58 1.29 2.27 2.09 1.8 3.36 2.31 3.17 4.39 5.01 2.6 1.79 1.83 3.14 2.42 2.53 2.04 2.41 2.01 1.87 1.78 1.79 2.3 2.41 3.88 2.38 CAR 16:0;OH 0.009 0.009 0.017 0.021 0.014 0.013 0.01 0.009 0.012 0.01 0.015 0.009 0.009 0.011 0.007 0.013 0.012 0.012 0.012 0.011 0.012 0.013 0.021 0.018 0.035 0.02 0.023 0.053 0.018 0.051 0.023 0.054 0.045 0.016 0.019 0.028 0.013 0.013 0.023 0.014 0.014 0.031 0.013 0.015 0.022 0.021 0.057 0.007 0.006 0.013 0.022 0.008 0.008 0.007 0.012 0.011 0.008 0.011 0.009 0.007 0.015 0.027 0.015 0.014 0.01 0.011 0.012 0.022 0.014 0.013 0.011 0.015 0.014 0.017 0.019 0.02 0.022 0.017 0.019 0.014 0.024 0.013 0.016 0.036 0.015 0.024 0.014 0.012 0.035 0.021 0.014 0.012 0.035 0.014 0.014 0.012 0.01 0.035 0.028 0.033 0.011 0.017 0.011 0.01 0.01 0.007 0.013 0.011 0.01 0.007 0.013 0.024 0.022 0.018 0.015 0.011 0.019 0.019 0.014 0.012 0.008 0.012 0.015 0.016 0.015 0.036 0.056 0.064 0.041 0.031 0.039 0.037 0.08 0.085 0.058 0.054 0.074 0.106 0.061 0.091 0.082 0.085 0.043 0.094 0.058 0.062 0.059 0.067 0.099 0.077 0.103 0.141 0.06 0.1 0.076 0.082 0.068 0.06 0.064 0.07 0.042 0.073 0.086 0.061 0.057 0.057 0.055 0.067 0.05 0.104 0.105 0.221 0.12 0.128 0.145 0.06 0.156 0.141 0.117 0.225 0.181 0.161 0.213 0.163 0.142 0.186 0.04 0.156 0.227 0.172 0.175 0.241 0.196 0.194 0.153 0.164 0.184 0.12 0.19 0.274 0.156 0.199 0.139 0.228 0.277 0.208 0.183 0.171 0.078 0.217 0.185 0.153 0.115 0.06 0.123 0.094 0.062 0.117 0.047 0.068 0.146 0.072 0.051 0.039 0.124 0.097 0.058 0.139 0.086 0.155 0.153 0.238 0.132 0.106 0.152 0.196 0.169 0.208 0.204 0.198 0.198 0.131 0.15 0.149 0.147 0.178 0.143 0.131 CAR 16:1;OH 0.006 0.005 0.009 0.013 0.008 0.009 0.006 0.006 0.007 0.007 0.01 0.006 0.006 0.009 0.005 0.011 0.008 0.007 0.008 0.008 0.007 0.009 0.01 0.01 0.023 0.009 0.01 0.024 0.007 0.036 0.012 0.029 0.031 0.008 0.006 0.013 0.007 0.008 0.014 0.007 0.007 0.019 0.008 0.006 0.013 0.011 0.041 0.004 0.004 0.01 0.016 0.005 0.006 0.004 0.008 0.007 0.005 0.007 0.005 0.004 0.006 0.019 0.006 0.006 0.004 0.005 0.004 0.009 0.005 0.005 0.005 0.006 0.009 0.007 0.009 0.008 0.009 0.007 0.007 0.006 0.008 0.006 0.007 0.028 0.006 0.008 0.005 0.006 0.02 0.014 0.009 0.008 0.021 0.01 0.01 0.007 0.007 0.022 0.024 0.029 0.01 0.012 0.006 0.007 0.008 0.005 0.007 0.008 0.006 0.005 0.009 0.015 0.014 0.011 0.01 0.007 0.011 0.014 0.008 0.01 0.005 0.008 0.012 0.013 0.012 0.013 0.014 0.017 0.016 0.008 0.01 0.012 0.017 0.017 0.009 0.017 0.012 0.017 0.008 0.015 0.012 0.015 0.006 0.016 0.011 0.013 0.018 0.009 0.017 0.009 0.012 0.021 0.01 0.017 0.014 0.011 0.023 0.008 0.011 0.007 0.007 0.015 0.009 0.008 0.008 0.007 0.009 0.014 0.004 0.016 0.009 0.102 0.023 0.034 0.049 0.017 0.042 0.042 0.026 0.058 0.045 0.037 0.047 0.043 0.025 0.024 0.01 0.029 0.03 0.022 0.024 0.037 0.033 0.033 0.021 0.025 0.028 0.024 0.029 0.044 0.025 0.031 0.018 0.02 0.034 0.022 0.033 0.028 0.027 0.03 0.024 0.027 0.033 0.018 0.022 0.022 0.021 0.032 0.014 0.019 0.055 0.03 0.02 0.017 0.047 0.033 0.027 0.054 0.035 0.048 0.062 0.073 0.06 0.043 0.056 0.081 0.07 0.091 0.077 0.07 0.099 0.07 0.064 0.096 0.055 0.073 0.059 0.053 CAR 18:0 0.095 0.085 0.13 0.127 0.092 0.091 0.091 0.074 0.108 0.108 0.117 0.105 0.107 0.114 0.068 0.109 0.109 0.099 0.111 0.094 0.09 0.102 0.115 0.27 0.287 0.266 0.418 0.663 0.344 0.358 0.246 0.497 0.48 0.243 0.391 0.243 0.162 0.243 0.273 0.186 0.199 0.336 0.248 0.211 0.32 0.376 0.641 0.103 0.083 0.105 0.238 0.083 0.094 0.071 0.1 0.101 0.086 0.118 0.09 0.084 0.336 0.378 0.305 0.341 0.376 0.234 0.329 0.444 0.312 0.343 0.25 0.334 0.248 0.292 0.208 0.347 0.34 0.258 0.23 0.247 0.335 0.231 0.305 0.413 0.225 0.31 0.233 0.228 0.428 0.279 0.279 0.144 0.426 0.178 0.172 0.244 0.217 0.496 0.44 0.456 0.198 0.143 0.11 0.104 0.103 0.098 0.114 0.115 0.115 0.08 0.122 0.371 0.473 0.302 0.393 0.326 0.403 0.326 0.243 0.231 0.243 0.302 0.202 0.27 0.202 0.62 0.69 0.508 0.483 0.578 0.497 0.54 0.625 1 0.772 1.18 1.34 0.936 0.678 0.906 1.1 1.46 0.731 0.939 0.66 1.03 0.735 0.834 1.15 1.09 1.38 1.64 0.62 1.14 0.832 0.716 0.943 0.694 0.613 1.06 0.61 0.793 0.888 0.664 0.587 0.724 0.738 0.709 0.541 1.15 1.39 1.67 0.744 1.49 0.62 0.986 1.1 0.591 0.776 1.15 1.32 1.15 1.61 0.685 2.68 1.89 0.921 1.6 1.02 0.879 2.22 2.09 1.55 1.27 1.63 1.14 1.78 0.892 0.81 1.81 1.91 0.944 2.22 0.957 1.11 2.11 1.14 1.79 1.09 0.977 1.02 0.958 1.34 0.874 1.14 0.881 0.602 1.08 0.621 0.96 1.31 1.26 0.956 0.733 1.1 1.11 0.561 1.41 1.47 2.32 1.98 2.5 1.42 0.714 1.28 1.76 1.35 1.4 1.32 1.27 1.14 1.09 1.36 1.24 1.22 1.92 1.96 0.959 CAR 18:0;OH 0.017 0.016 0.02 0.027 0.02 0.015 0.015 0.015 0.018 0.019 0.02 0.016 0.016 0.017 0.013 0.015 0.019 0.02 0.018 0.016 0.017 0.018 0.024 0.029 0.033 0.028 0.032 0.054 0.03 0.053 0.032 0.057 0.054 0.031 0.034 0.033 0.021 0.026 0.03 0.021 0.023 0.034 0.018 0.023 0.029 0.032 0.057 0.02 0.015 0.024 0.03 0.022 0.017 0.017 0.022 0.02 0.018 0.022 0.019 0.018 0.027 0.034 0.031 0.032 0.026 0.025 0.029 0.041 0.029 0.025 0.026 0.032 0.019 0.032 0.029 0.035 0.038 0.032 0.03 0.026 0.037 0.027 0.032 0.044 0.026 0.038 0.028 0.017 0.043 0.026 0.021 0.016 0.037 0.02 0.018 0.018 0.018 0.037 0.032 0.035 0.017 0.023 0.017 0.016 0.014 0.013 0.018 0.019 0.014 0.014 0.018 0.029 0.03 0.021 0.022 0.019 0.027 0.022 0.017 0.017 0.015 0.021 0.018 0.017 0.018 0.053 0.083 0.096 0.055 0.051 0.054 0.05 0.081 0.1 0.088 0.084 0.094 0.102 0.081 0.103 0.104 0.128 0.062 0.118 0.081 0.098 0.075 0.101 0.125 0.12 0.15 0.223 0.102 0.14 0.116 0.122 0.094 0.094 0.099 0.128 0.074 0.106 0.129 0.084 0.096 0.091 0.084 0.084 0.073 0.143 0.165 0.239 0.107 0.133 0.121 0.082 0.126 0.108 0.111 0.161 0.146 0.134 0.185 0.118 0.215 0.2 0.067 0.163 0.176 0.141 0.195 0.236 0.192 0.159 0.141 0.148 0.181 0.107 0.134 0.246 0.187 0.169 0.188 0.17 0.214 0.219 0.168 0.158 0.1 0.19 0.166 0.135 0.131 0.094 0.132 0.112 0.086 0.133 0.063 0.088 0.131 0.109 0.075 0.056 0.122 0.104 0.055 0.125 0.118 0.167 0.179 0.275 0.134 0.091 0.146 0.194 0.155 0.175 0.179 0.166 0.155 0.121 0.155 0.115 0.14 0.159 0.147 0.112 CAR 18:1 0.222 0.202 0.441 0.383 0.299 0.258 0.195 0.238 0.315 0.322 0.392 0.324 0.295 0.398 0.231 0.464 0.429 0.314 0.356 0.376 0.325 0.342 0.311 0.446 0.699 0.355 0.438 1.12 0.33 0.835 0.466 0.716 0.835 0.36 0.379 0.428 0.369 0.37 0.508 0.321 0.344 0.602 0.448 0.257 0.454 0.645 0.979 0.261 0.237 0.359 0.522 0.243 0.29 0.197 0.362 0.293 0.265 0.374 0.239 0.232 0.319 0.66 0.363 0.401 0.344 0.3 0.316 0.453 0.35 0.329 0.26 0.384 0.318 0.347 0.328 0.385 0.451 0.328 0.267 0.279 0.368 0.266 0.423 0.707 0.315 0.34 0.237 0.344 0.663 0.399 0.465 0.28 0.593 0.326 0.275 0.301 0.388 0.636 0.848 0.734 0.402 0.442 0.341 0.294 0.458 0.302 0.336 0.414 0.287 0.264 0.375 0.548 0.644 0.408 0.485 0.449 0.48 0.572 0.391 0.405 0.288 0.359 0.407 0.46 0.411 3.75 1.73 1.74 1.33 1.55 0.979 2.09 0.618 1.31 0.356 3.03 0.896 1.16 0.54 1.3 0.66 0.972 0.42 0.881 0.642 0.886 2.4 0.523 1.13 0.849 0.837 1.24 0.591 1.33 0.638 0.485 1.59 0.503 0.512 0.717 0.454 0.664 0.627 0.687 0.798 0.462 0.587 0.956 0.388 0.846 0.676 4.7 1.19 3.76 2.44 1.85 3.3 2.48 2.37 3 4.3 2.57 4.22 2.62 3.45 1.97 1.45 2.59 1.66 1.37 2.04 3.2 1.83 1.36 1.92 1.46 1.78 1.69 1.06 2.76 2.23 1.59 1.81 1.12 1.7 2.06 2.01 2.42 2.19 1 1.86 1.77 2.41 1.43 1.22 2.02 2.02 2.22 2.83 1.95 1.71 2.24 3.02 2.89 4.06 2.93 4.65 5.86 4.15 3.26 5.68 6.85 3.1 3.74 2.74 5.33 5.19 5.05 3.06 4.12 3.93 4.09 2.77 3 4.52 3.52 6.91 4.98 CAR 18:2 0.032 0.04 0.07 0.062 0.039 0.041 0.035 0.031 0.066 0.048 0.071 0.044 0.064 0.065 0.038 0.087 0.073 0.046 0.057 0.059 0.041 0.053 0.047 0.106 0.184 0.089 0.105 0.255 0.079 0.19 0.108 0.19 0.163 0.087 0.086 0.122 0.1 0.097 0.109 0.08 0.1 0.167 0.075 0.071 0.149 0.147 0.2 0.034 0.037 0.051 0.102 0.046 0.04 0.033 0.054 0.054 0.038 0.048 0.05 0.036 0.075 0.107 0.097 0.096 0.071 0.079 0.077 0.119 0.074 0.08 0.062 0.083 0.066 0.086 0.095 0.089 0.118 0.086 0.063 0.073 0.094 0.069 0.108 0.129 0.08 0.079 0.059 0.062 0.11 0.071 0.093 0.05 0.138 0.059 0.054 0.059 0.068 0.111 0.149 0.14 0.069 0.078 0.062 0.066 0.088 0.054 0.058 0.057 0.052 0.042 0.081 0.117 0.132 0.081 0.094 0.087 0.114 0.124 0.097 0.081 0.056 0.086 0.086 0.104 0.105 1.2 0.427 0.419 0.352 0.33 0.202 0.473 0.219 0.757 0.127 0.577 0.296 0.346 0.154 0.376 0.205 0.388 0.178 0.247 0.145 0.247 0.574 0.273 0.53 0.421 0.458 0.445 0.278 0.576 0.296 0.233 0.51 0.286 0.274 0.452 0.136 0.315 0.313 0.35 0.402 0.24 0.276 0.292 0.27 0.423 0.303 1.54 0.225 0.767 0.366 0.54 0.608 0.348 0.443 0.577 0.99 0.411 0.867 0.545 0.721 0.916 0.445 0.925 0.808 0.546 0.987 1.42 0.711 0.532 0.816 0.696 0.725 0.396 0.38 1.09 0.927 0.675 0.867 0.608 0.776 1.14 0.735 0.998 0.654 0.309 0.574 0.72 0.997 0.467 0.334 0.479 0.791 0.657 0.974 0.774 0.627 0.777 1.06 1.02 0.988 0.831 1.08 1.34 1.05 0.777 1.52 1.71 0.726 0.81 0.975 1.74 1.74 1.56 1.14 1.53 1.33 1.18 0.813 0.888 1.65 1.25 1.97 1.73 CAR 2:0 8.92 10.8 12.2 13 6.26 9.31 9.95 7.27 9.86 6.34 10.6 7.66 6.6 8.31 6.4 9.32 9.08 7.53 8.55 9.28 8.93 9.21 13.7 8.58 22.5 12.8 18.7 33.5 8.46 21.7 13.8 21.7 24.5 11.1 11.8 27.1 19.6 18.3 23.1 20.6 17.8 21.8 6.29 14 24.3 18.4 30.1 4.35 6.19 8.53 13.3 5.32 6.96 4.55 8.66 6.97 5.47 7.18 10.5 5.57 6.43 7.73 7.93 7.49 4.62 5.8 6.64 12.3 5.9 6.21 6.87 7.29 7.67 8.44 17 13.7 14.8 10.3 15.5 17.1 12 15.2 20.4 15.6 17.5 13.4 19.6 2.95 15.6 7.56 5.63 12.5 22.7 14.6 13.3 11.8 6.94 22.6 39.8 19.4 8.57 23.5 12.4 8.38 21 14.8 15.3 15.7 7.58 10.8 14.2 12.2 16.1 18.2 11.8 6.43 17.3 22.5 26.2 20.6 10.8 26 26.8 24.4 24.3 42.3 29 36.2 30.7 23.3 16.8 30.6 30 26.3 14.1 29.7 21.5 33.5 30.6 35.1 20.5 39.4 9.95 39.1 28.6 23.9 41.1 24 39.5 35.7 35.8 65.9 27.2 59.4 46.6 23.6 41.1 35.5 49 43.5 15.8 39 38 46.9 59.8 25.4 32.5 24.1 38.2 38.6 36.7 37.9 47.7 60.7 51.8 28.6 59.2 58.6 52.1 59.2 69 51.1 65.6 51.6 57 68.6 18.3 55 72.9 60.3 49.4 70.4 64 49.6 72.2 57.9 59.4 19.3 59.1 87.5 72 80.5 53.1 62 89.6 73.8 82.4 58.3 45.5 86 66.6 85.1 44.7 35.3 21.4 21.5 37.6 32.4 41.7 30 36.4 34.2 39.6 33.9 54.2 40.6 35.3 47.3 45.9 34.5 52.8 59.6 40.8 43.2 79.6 90.4 85 90.8 75.8 81.5 84.7 57.3 60.3 50.2 93.1 55.7 80.5 79 CAR 20:4 0.029 0.041 0.043 0.066 0.029 0.031 0.033 0.038 0.052 0.039 0.038 0.042 0.041 0.033 0.03 0.044 0.033 0.042 0.037 0.036 0.041 0.039 0.038 0.062 0.065 0.047 0.05 0.115 0.041 0.098 0.066 0.078 0.094 0.048 0.046 0.064 0.064 0.055 0.072 0.05 0.069 0.08 0.063 0.063 0.067 0.075 0.087 0.032 0.036 0.047 0.065 0.042 0.048 0.032 0.048 0.048 0.027 0.046 0.045 0.039 0.056 0.062 0.058 0.044 0.041 0.046 0.038 0.067 0.043 0.045 0.038 0.037 0.05 0.052 0.071 0.069 0.065 0.065 0.048 0.046 0.05 0.06 0.074 0.082 0.065 0.057 0.05 0.038 0.063 0.06 0.056 0.049 0.057 0.052 0.035 0.045 0.054 0.047 0.1 0.081 0.047 0.047 0.031 0.047 0.062 0.045 0.047 0.058 0.03 0.037 0.055 0.077 0.077 0.062 0.058 0.054 0.063 0.078 0.057 0.054 0.037 0.053 0.067 0.058 0.067 0.392 0.133 0.116 0.113 0.092 0.079 0.148 0.148 0.626 0.107 0.174 0.209 0.246 0.087 0.256 0.112 0.162 0.132 0.146 0.081 0.203 0.156 0.118 0.251 0.126 0.168 0.179 0.161 0.275 0.148 0.14 0.16 0.094 0.12 0.134 0.074 0.174 0.164 0.162 0.226 0.088 0.179 0.072 0.106 0.285 0.163 0.351 0.128 0.644 0.16 0.186 0.286 0.175 0.189 0.359 0.428 0.186 0.566 0.255 0.509 0.434 0.119 0.313 0.244 0.168 0.415 0.415 0.275 0.145 0.286 0.29 0.24 0.107 0.127 0.471 0.411 0.198 0.413 0.238 0.306 0.455 0.278 0.343 0.224 0.118 0.15 0.262 0.279 0.192 0.085 0.105 0.244 0.157 0.294 0.174 0.103 0.209 0.266 0.302 0.278 0.263 0.305 0.385 0.319 0.267 0.571 0.304 0.248 0.217 0.287 0.473 0.438 0.51 0.31 0.464 0.363 0.373 0.342 0.309 0.465 0.438 0.508 0.444 CAR 3:0 0.197 0.257 0.39 0.301 0.107 0.218 0.257 0.25 0.225 0.147 0.172 0.21 0.122 0.121 0.177 0.179 0.157 0.137 0.173 0.334 0.179 0.218 0.437 0.173 0.134 0.339 0.423 0.585 0.269 0.177 0.143 0.191 0.698 0.126 0.319 0.309 0.452 0.303 0.185 0.388 0.395 0.16 0.459 1.44 0.278 0.253 0.26 0.108 0.107 0.179 0.406 0.114 0.179 0.081 0.2 0.178 0.099 0.157 0.166 0.137 0.125 0.215 0.1 0.149 0.085 0.149 0.102 0.304 0.134 0.098 0.137 0.113 0.225 0.13 0.292 0.32 0.187 0.203 0.396 0.226 0.225 0.362 0.5 0.195 0.31 0.491 0.308 0.043 0.253 0.37 0.134 0.804 0.133 0.293 0.416 0.629 0.357 0.12 0.51 0.37 0.247 0.544 0.274 0.186 0.25 0.368 0.247 0.305 0.133 0.341 0.304 0.171 0.193 0.353 0.255 0.737 0.24 0.327 0.391 0.306 0.215 0.482 0.361 0.401 0.471 2.43 1.11 1.05 1.12 0.847 0.453 1.47 0.595 0.577 0.334 1.13 0.445 0.598 0.645 0.666 0.329 0.51 0.204 1.13 0.488 0.524 1.31 0.334 1.27 0.552 0.623 1.14 0.754 2.3 0.823 0.497 1.08 0.622 1.04 0.499 0.326 0.543 0.454 0.728 0.816 0.319 0.604 0.493 0.459 0.636 0.571 0.935 0.861 1.67 1.51 0.739 1.26 1.76 1.23 1.27 1.4 0.964 1.41 1.4 1.02 1.34 0.383 1.02 1.23 0.936 0.703 1.06 1.22 0.668 1.46 0.999 0.88 0.347 1.19 1.59 1.06 1.47 0.712 1.08 1.79 1.16 1.67 1.24 1.35 1.44 1.97 1.87 1.25 0.872 0.437 0.419 1.27 0.805 1.23 0.773 0.658 1.29 0.961 0.893 1.41 0.908 0.787 1.33 0.88 0.717 1.31 1.35 0.855 1.09 1.41 1.72 1.69 1.59 1.4 1.75 1.59 1.13 1.06 0.894 2.13 0.902 1.55 1.64 CAR 4:0 0.095 0.127 0.259 0.202 0.078 0.157 0.134 0.215 0.238 0.134 0.162 0.098 0.16 0.114 0.321 0.111 0.26 0.176 0.288 0.218 0.219 0.189 0.277 0.056 0.152 0.092 0.159 0.324 0.062 0.157 0.073 0.157 0.117 0.072 0.081 0.197 0.184 0.147 0.191 0.159 0.145 0.143 0.049 0.207 0.189 0.154 0.087 0.108 0.121 0.264 0.107 0.199 0.211 0.068 0.221 0.215 0.1 0.22 0.173 0.157 0.053 0.074 0.047 0.049 0.035 0.042 0.044 0.078 0.048 0.041 0.047 0.071 0.053 0.056 0.123 0.148 0.121 0.098 0.146 0.166 0.126 0.134 0.185 0.067 0.132 0.119 0.166 0.02 0.094 0.08 0.043 0.108 0.137 0.095 0.086 0.13 0.094 0.136 0.218 0.137 0.063 0.415 0.155 0.127 0.259 0.25 0.169 0.189 0.081 0.325 0.256 0.06 0.067 0.096 0.062 0.061 0.069 0.117 0.144 0.108 0.083 0.286 0.131 0.127 0.153 2.92 2.28 3.08 2.39 1.57 2.69 2.19 1.55 1.49 0.684 1.77 1.19 1.89 2 2.22 1.15 2.07 0.499 2.77 1.88 1.36 3.99 0.984 2.26 1.74 1.71 3.13 1.51 3.81 2.16 1.39 2.79 1.76 1.95 1.82 0.768 1.96 2.18 3.06 2.67 1.14 1.52 3.53 1.74 2.87 2.65 2.2 2.82 2.31 3.45 2.67 3.41 2.96 2.83 2.75 3.53 3.58 2.95 3.67 2.24 3.98 1.84 3.67 4.39 4.73 3.23 3.79 3.56 4.64 4.22 3.97 4.62 2.56 4.02 5.65 4.01 5.35 2.57 4.67 5.78 4.28 4.6 3.7 2.56 6.25 3.79 4.4 3.48 3.02 2.69 3.25 2.3 3.83 2.77 3.57 2.41 1.98 3.04 2.57 3.86 2.84 2.3 2.85 2.34 2.52 2.42 3.3 2.58 3.42 4.03 4.86 4.31 4.75 4.25 3.7 4.67 2.53 3.1 2.57 5.69 2.64 4.2 4.41 CAR 4:0;OH 0.109 0.111 0.182 0.156 0.108 0.122 0.107 0.099 0.088 0.055 0.129 0.086 0.053 0.101 0.042 0.112 0.095 0.072 0.079 0.085 0.079 0.091 0.211 0.153 0.411 0.209 0.254 1.12 0.089 0.563 0.215 0.664 0.915 0.143 0.176 0.407 0.224 0.171 0.386 0.211 0.228 0.46 0.217 0.194 0.397 0.332 0.828 0.031 0.033 0.074 0.407 0.026 0.048 0.027 0.077 0.047 0.055 0.052 0.071 0.03 0.105 0.305 0.11 0.171 0.083 0.105 0.13 0.224 0.114 0.102 0.098 0.163 0.156 0.159 0.297 0.288 0.361 0.183 0.328 0.327 0.256 0.195 0.246 0.509 0.213 0.206 0.239 0.041 0.528 0.366 0.168 0.239 0.58 0.244 0.275 0.303 0.092 0.648 0.891 0.649 0.176 0.338 0.132 0.137 0.214 0.123 0.204 0.153 0.124 0.142 0.163 0.322 0.338 0.41 0.294 0.252 0.396 0.442 0.4 0.392 0.156 0.409 0.345 0.361 0.48 2.16 0.656 1.07 0.784 0.547 0.637 0.622 1.19 0.809 0.394 0.624 0.573 1.19 0.766 1.5 0.753 1.97 0.233 1.37 0.895 0.72 1.23 1.43 3.22 2.04 1.9 4.88 1.52 4.32 2.57 2.24 3.49 1.82 2.43 1.85 0.404 1.78 2.03 2.62 2.82 1.2 2.05 2 1.65 2.93 2.6 3.57 0.785 1.11 1.7 1.87 0.895 1.21 0.959 1.52 1.2 1.31 1.17 1.84 0.707 7.02 1.58 5.19 8.82 6.2 3.88 6.04 5.96 5.04 7.17 5.36 6.27 1.41 6.96 9.08 5.5 9.39 4.09 5.74 9.38 4.71 7.43 4.87 3.51 7.63 6.44 7.93 3.03 2.54 1.36 1.5 3.07 1.91 2.11 1.63 3.78 2.54 2.91 1.6 1.57 0.964 1.29 1.79 0.976 1.01 1.05 1.53 0.968 1.14 8.96 8.43 8.08 7.84 7.03 7.04 7.94 4.27 5.98 4.59 8.09 4.53 5.66 5.94 CAR 5:0 0.007 0.009 0.019 0.009 0.007 0.008 0.007 0.009 0.006 0.004 0.004 0.008 0.003 0.003 0.008 0.006 0.007 0.005 0.007 0.008 0.005 0.005 0.016 0.005 0.007 0.006 0.01 0.017 0.005 0.005 0.004 0.007 0.009 0.004 0.006 0.007 0.009 0.008 0.007 0.007 0.008 0.007 0.006 0.039 0.008 0.006 0.01 0.005 0.004 0.006 0.011 0.005 0.005 0.003 0.007 0.006 0.004 0.005 0.005 0.003 0.004 0.007 0.004 0.004 0.003 0.003 0.005 0.007 0.004 0.003 0.004 0.005 0.007 0.004 0.008 0.009 0.006 0.005 0.008 0.008 0.007 0.009 0.009 0.008 0.007 0.009 0.005 0.004 0.01 0.009 0.006 0.011 0.008 0.01 0.01 0.017 0.014 0.008 0.018 0.009 0.008 0.025 0.008 0.008 0.009 0.008 0.008 0.009 0.006 0.019 0.014 0.007 0.008 0.008 0.008 0.011 0.01 0.01 0.011 0.008 0.007 0.017 0.009 0.009 0.011 0.047 0.04 0.045 0.041 0.029 0.043 0.051 0.02 0.021 0.008 0.038 0.021 0.027 0.02 0.027 0.013 0.011 0.006 0.045 0.017 0.012 0.05 0.007 0.029 0.012 0.015 0.022 0.022 0.037 0.014 0.012 0.035 0.013 0.017 0.009 0.009 0.01 0.018 0.016 0.022 0.011 0.015 0.036 0.012 0.023 0.022 0.034 0.043 0.035 0.048 0.034 0.048 0.05 0.04 0.038 0.053 0.033 0.045 0.036 0.03 0.035 0.028 0.033 0.03 0.032 0.021 0.03 0.034 0.027 0.032 0.026 0.028 0.03 0.028 0.049 0.037 0.042 0.022 0.036 0.042 0.036 0.053 0.027 0.043 0.057 0.035 0.034 0.05 0.04 0.033 0.039 0.029 0.099 0.043 0.072 0.029 0.03 0.042 0.036 0.04 0.032 0.027 0.033 0.031 0.031 0.034 0.043 0.031 0.037 0.038 0.045 0.038 0.042 0.035 0.038 0.043 0.029 0.031 0.028 0.054 0.028 0.041 0.041 CAR 5:1 0.013 0.011 0.01 0.01 0.01 0.011 0.013 0.009 0.011 0.006 0.007 0.014 0.006 0.006 0.006 0.009 0.005 0.006 0.007 0.011 0.009 0.007 0.009 0.003 0.005 0.005 0.005 0.006 0.004 0.005 0.005 0.006 0.009 0.004 0.004 0.006 0.005 0.005 0.006 0.005 0.007 0.005 0.006 0.006 0.007 0.005 0.008 0.006 0.005 0.007 0.01 0.006 0.008 0.005 0.007 0.008 0.004 0.007 0.005 0.006 0.004 - 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.003 0.003 - 0.004 0.006 0.005 0.005 0.006 0.005 0.005 0.005 0.007 0.006 - 0.005 0.007 0.004 - 0.008 0.01 - - - 0.008 0.01 0.009 0.01 - 0.011 0.014 0.008 0.009 0.012 0.008 0.012 0.008 0.013 0.01 0.01 0.009 0.013 - - 0.009 - - - 0.009 - - - 0.01 - - 0.009 0.897 0.562 0.593 0.48 0.316 0.39 0.633 0.045 0.052 0.021 0.604 0.093 0.077 0.027 0.086 0.025 0.019 0.018 0.07 0.03 0.05 0.757 0.022 0.119 0.028 0.045 0.091 0.071 0.144 0.027 0.035 0.593 0.032 0.042 0.019 0.021 0.027 0.034 0.042 0.049 0.017 0.061 0.38 0.019 0.081 0.049 0.511 0.016 0.025 0.026 0.413 0.022 0.032 0.019 0.022 0.027 0.016 0.022 0.04 0.022 0.013 0.36 0.012 0.013 0.013 - 0.012 0.016 0.011 0.013 0.013 0.011 0.343 0.019 0.015 0.011 0.014 - 0.014 0.018 0.01 0.016 - 0.614 0.015 0.012 0.016 0.697 0.526 0.27 0.314 0.694 0.452 0.812 0.409 0.471 0.425 0.618 0.551 0.042 0.027 0.038 0.039 0.026 0.026 0.035 0.034 0.039 0.04 0.042 0.05 0.05 0.063 0.045 0.045 0.043 0.044 0.045 0.047 0.05 0.04 0.039 0.058 CAR 6:0 0.015 0.016 0.034 0.037 0.01 0.021 0.014 0.018 0.036 0.029 0.037 0.013 0.025 0.029 0.034 0.038 0.039 0.033 0.05 0.037 0.033 0.029 0.034 0.019 0.043 0.02 0.039 0.066 0.022 0.051 0.021 0.05 0.029 0.02 0.017 0.051 0.038 0.035 0.058 0.045 0.032 0.043 0.008 0.034 0.065 0.059 0.04 0.016 0.019 0.035 0.031 0.028 0.025 0.015 0.037 0.035 0.02 0.029 0.026 0.024 0.016 0.016 0.021 0.015 0.01 0.012 0.013 0.023 0.017 0.012 0.015 0.017 0.012 0.015 0.035 0.036 0.036 0.022 0.03 0.043 0.038 0.031 0.044 0.023 0.035 0.033 0.029 0.003 0.026 0.015 0.01 0.023 0.047 0.023 0.019 0.052 0.039 0.084 0.083 0.046 0.014 0.053 0.015 0.013 0.047 0.027 0.025 0.03 0.012 0.037 0.042 0.019 0.021 0.022 0.014 0.014 0.02 0.034 0.054 0.033 0.026 0.201 0.037 0.039 0.043 0.126 0.085 0.117 0.098 0.065 0.075 0.107 0.066 0.082 0.038 0.078 0.082 0.142 0.084 0.123 0.078 0.111 0.041 0.14 0.076 0.07 0.134 0.059 0.101 0.062 0.07 0.115 0.071 0.126 0.094 0.05 0.087 0.06 0.074 0.069 0.048 0.091 0.078 0.085 0.107 0.059 0.091 0.101 0.075 0.119 0.068 0.163 0.308 0.584 0.483 0.122 0.601 0.523 0.448 0.475 0.518 0.408 0.454 0.562 0.329 0.416 0.069 0.477 0.374 0.331 0.276 0.368 0.383 0.303 0.432 0.31 0.288 0.066 0.401 0.566 0.39 0.435 0.256 0.408 0.531 0.419 0.516 0.46 0.125 0.402 0.407 0.445 0.146 0.113 0.071 0.098 0.107 0.135 0.123 0.117 0.162 0.112 0.128 0.104 0.266 0.188 0.128 0.244 0.154 0.194 0.332 0.266 0.203 0.247 0.271 0.244 0.256 0.24 0.224 0.216 0.242 0.18 0.189 0.159 0.398 0.189 0.302 0.28 CAR 6:0;OH 0.014 0.013 0.019 0.024 0.013 0.017 0.014 0.013 0.007 0.002 0.008 0.013 - 0.003 0.002 0.007 0.003 0.004 0.007 0.007 0.003 0.007 0.02 0.002 0.01 0.002 0.012 0.032 - 0.013 0.006 0.016 0.029 0.003 0.002 0.016 0.008 0.011 0.016 0.011 0.013 0.014 0.012 0.009 0.021 0.015 0.03 - - 0.005 0.025 - 0.002 - 0.008 0.003 0.002 - 0.003 - - 0.02 - - - - - 0.004 - - - - 0.015 0.002 0.009 0.011 0.012 0.006 0.014 0.011 0.01 0.007 0.009 0.024 0.009 0.008 0.009 0.008 0.027 0.018 0.012 0.018 0.037 0.02 0.02 0.026 0.014 0.044 0.043 0.04 0.018 0.034 0.016 0.015 0.021 0.014 0.021 0.017 0.018 0.017 0.022 0.015 0.018 0.022 0.015 0.014 0.018 0.02 0.027 0.02 0.016 0.029 0.025 0.027 0.03 0.031 0.021 0.024 0.021 0.014 0.016 0.022 0.02 0.027 0.013 0.022 0.021 0.027 0.02 0.028 0.019 0.041 0.01 0.024 0.013 0.018 0.031 0.02 0.037 0.021 0.031 0.057 0.029 0.037 0.037 0.023 0.037 0.014 0.031 0.024 0.01 0.044 0.036 0.037 0.067 0.03 0.039 0.023 0.027 0.051 0.028 0.138 0.091 0.11 0.123 0.034 0.109 0.144 0.098 0.102 0.122 0.084 0.099 0.125 0.067 0.14 0.019 0.109 0.112 0.117 0.078 0.113 0.148 0.097 0.13 0.103 0.106 0.021 0.122 0.161 0.132 0.158 0.103 0.133 0.185 0.11 0.181 0.118 0.038 0.154 0.146 0.183 0.044 0.029 0.022 0.022 0.069 0.034 0.041 0.037 0.104 0.042 0.032 0.029 0.113 0.095 0.1 0.14 0.072 0.085 0.125 0.142 0.086 0.103 0.158 0.204 0.164 0.198 0.156 0.162 0.157 0.147 0.152 0.111 0.219 0.144 0.173 0.182 CAR 8:0 0.006 0.01 0.011 0.015 0.006 0.011 0.008 0.006 0.011 0.013 0.013 0.011 0.012 0.011 0.01 0.015 0.01 0.013 0.02 0.012 0.012 0.012 0.012 0.01 0.019 0.01 0.016 0.028 0.01 0.021 0.012 0.018 0.012 0.01 0.011 0.02 0.016 0.02 0.02 0.018 0.02 0.022 0.007 0.018 0.046 0.032 0.015 0.01 0.01 0.017 0.032 0.013 0.012 0.009 0.015 0.017 0.011 0.013 0.013 0.011 0.009 0.009 0.012 0.01 0.009 0.01 0.011 0.014 0.01 0.008 0.01 0.01 0.008 0.011 0.023 0.023 0.024 0.016 0.019 0.03 0.025 0.019 0.022 0.013 0.019 0.021 0.016 0.004 0.016 0.01 0.006 0.014 0.027 0.019 0.018 0.053 0.035 0.045 0.042 0.029 0.01 0.019 0.007 0.008 0.021 0.01 0.011 0.013 0.007 0.011 0.016 0.011 0.011 0.011 0.008 0.008 0.01 0.015 0.031 0.017 0.012 0.387 0.02 0.028 0.026 0.071 0.036 0.037 0.035 0.029 0.027 0.04 0.021 0.027 0.016 0.037 0.034 0.041 0.022 0.036 0.027 0.036 0.018 0.042 0.027 0.025 0.042 0.025 0.027 0.02 0.024 0.032 0.022 0.042 0.031 0.021 0.029 0.021 0.025 0.024 0.02 0.03 0.02 0.022 0.037 0.021 0.025 0.026 0.02 0.036 0.022 0.055 0.096 0.136 0.156 0.058 0.132 0.18 0.146 0.112 0.147 0.13 0.124 0.172 0.093 0.097 0.027 0.098 0.118 0.119 0.072 0.095 0.131 0.106 0.115 0.134 0.094 0.026 0.167 0.127 0.103 0.184 0.089 0.157 0.251 0.137 0.218 0.143 0.041 0.156 0.244 0.186 0.051 0.04 0.027 0.031 0.075 0.116 0.049 0.044 0.086 0.055 0.042 0.037 0.108 0.075 0.058 0.089 0.061 0.078 0.116 0.102 0.063 0.093 0.115 0.087 0.107 0.086 0.08 0.082 0.077 0.087 0.071 0.062 0.251 0.085 0.123 0.134 CAR DC3:0 0.046 0.05 0.038 0.041 0.043 0.058 0.067 0.044 0.013 0.033 0.013 0.07 0.01 0.021 0.012 0.011 0.017 0.01 0.016 0.023 0.016 0.042 0.051 0.022 0.013 0.041 0.02 0.028 0.009 0.017 0.031 0.015 0.064 0.018 0.018 0.045 0.02 0.023 0.028 0.016 0.037 0.023 0.072 0.032 0.055 0.024 0.032 0.017 0.009 0.014 0.064 0.008 0.013 0.007 0.042 0.014 0.018 0.008 0.013 0.007 0.016 0.058 0.014 0.01 0.022 0.015 0.008 0.031 0.02 0.008 0.015 0.017 0.046 0.027 0.024 0.032 0.03 0.026 0.049 0.026 0.034 0.026 0.021 0.06 0.03 0.033 0.018 0.054 0.062 0.101 0.056 0.055 0.04 0.041 0.052 0.065 0.041 0.035 0.04 0.081 0.053 0.042 0.042 0.027 0.025 0.024 0.038 0.041 0.028 0.027 0.036 0.048 0.029 0.058 0.032 0.037 0.032 0.033 0.036 0.035 0.034 0.036 0.028 0.037 0.045 CAR DC4:0 0.059 0.048 0.03 0.034 0.028 0.085 0.073 0.031 0.021 0.035 0.017 0.058 0.021 0.028 0.019 0.025 0.025 0.019 0.023 0.054 0.018 0.055 0.053 0.039 0.015 0.041 0.027 0.026 0.025 0.02 0.037 0.013 0.03 0.024 0.029 0.046 0.028 0.029 0.017 0.027 0.058 0.02 0.067 0.052 0.06 0.02 0.025 0.026 0.013 0.02 0.073 0.017 0.025 0.019 0.089 0.027 0.021 0.012 0.018 0.015 0.022 0.063 0.014 0.02 0.025 0.018 0.015 0.052 0.021 0.013 0.019 0.015 0.067 0.028 0.035 0.058 0.046 0.034 0.087 0.04 0.051 0.036 0.037 0.024 0.049 0.038 0.03 0.051 0.066 0.17 0.053 0.057 0.058 0.037 0.043 0.059 0.064 0.064 0.04 0.118 0.051 0.031 0.038 0.021 0.019 0.019 0.027 0.028 0.027 0.025 0.026 0.053 0.036 0.076 0.041 0.043 0.035 0.035 0.057 0.029 0.043 0.049 0.024 0.028 0.047 0.098 0.12 0.073 0.059 0.046 0.063 0.068 0.057 0.074 0.028 0.051 0.121 0.131 0.044 0.179 0.049 0.04 0.031 0.074 0.034 0.059 0.084 0.04 0.087 0.044 0.061 0.073 0.075 0.102 0.076 0.036 0.046 0.041 0.056 0.037 0.026 0.047 0.035 0.047 0.067 0.023 0.057 0.057 0.031 0.069 0.069 0.132 0.148 0.101 0.186 0.053 0.177 0.178 0.166 0.155 0.214 0.145 0.15 0.166 0.12 0.065 0.028 0.078 0.116 0.106 0.058 0.078 0.102 0.106 0.084 0.099 0.092 0.054 0.13 0.105 0.092 0.115 0.08 0.12 0.126 0.099 0.155 0.088 0.046 0.134 0.131 0.146 0.054 0.056 0.05 0.052 0.068 0.067 0.072 0.07 0.091 0.053 0.062 0.059 0.419 0.315 0.456 0.379 0.274 0.223 0.3 0.35 0.248 0.409 0.322 0.333 0.378 0.285 0.292 0.247 0.33 0.242 0.181 0.244 0.307 0.21 0.334 0.389 CAR DC5:0 0.029 0.043 0.032 0.039 0.038 0.036 0.037 0.03 0.023 0.022 0.039 0.053 0.027 0.029 0.022 0.05 0.026 0.025 0.05 0.046 0.014 0.022 0.032 0.047 0.013 0.068 0.036 0.118 0.026 0.018 0.04 0.054 0.059 0.042 0.073 0.111 0.056 0.137 0.046 0.079 0.158 0.041 0.108 0.117 0.022 0.049 0.052 0.024 0.021 0.021 0.102 0.014 0.024 0.008 0.031 0.018 0.04 0.013 0.015 0.012 0.035 0.14 0.025 0.036 0.032 0.032 0.019 0.056 0.038 0.015 0.036 0.018 0.08 0.059 0.098 0.122 0.155 0.088 0.108 0.099 0.107 0.098 0.073 0.077 0.111 0.108 0.046 0.06 0.094 0.074 0.073 0.074 0.088 0.056 0.06 0.074 0.047 0.086 0.06 0.085 0.09 0.05 0.034 0.032 0.027 0.021 0.033 0.034 0.037 0.03 0.053 0.075 0.058 0.068 0.071 0.173 0.059 0.074 0.046 0.095 0.118 0.044 0.037 0.057 0.064 CAR DC5:0;3Me 0.032 0.032 0.043 0.044 0.035 0.036 0.027 0.029 0.039 0.024 0.039 0.043 0.033 0.034 0.024 0.042 0.035 0.028 0.039 0.037 0.023 0.026 0.041 0.045 0.047 0.06 0.047 0.082 0.039 0.044 0.055 0.081 0.186 0.053 0.072 0.118 0.056 0.078 0.074 0.068 0.061 0.077 0.183 0.072 0.07 0.085 0.118 0.022 0.024 0.034 0.117 0.022 0.027 0.021 0.032 0.03 0.036 0.023 0.027 0.022 0.047 0.351 0.034 0.06 0.055 0.043 0.052 0.073 0.077 0.038 0.036 0.054 0.09 0.057 0.091 0.133 0.133 0.082 0.11 0.097 0.118 0.086 0.069 0.196 0.088 0.087 0.055 0.073 0.176 0.172 0.124 0.085 0.394 0.081 0.078 0.152 0.083 0.393 0.202 0.208 0.121 0.043 0.03 0.025 0.034 0.019 0.034 0.027 0.041 0.026 0.056 0.077 0.091 0.075 0.121 0.176 0.127 0.099 0.086 0.113 0.154 0.151 0.066 0.15 0.09 0.032 - 0.027 - - - - 0.017 0.016 0.019 - 0.016 0.019 0.015 0.015 0.018 0.049 0.016 0.017 0.015 0.016 - 0.059 0.024 0.026 0.038 0.028 0.022 0.021 0.026 0.035 0.051 0.03 0.022 0.026 0.016 0.044 0.05 0.029 0.027 0.028 0.031 0.045 0.032 0.026 0.029 0.043 0.016 0.017 0.016 0.038 0.015 0.016 0.016 0.02 0.017 0.017 0.017 0.016 0.016 0.025 0.054 0.021 0.029 0.024 0.03 0.025 0.027 0.036 0.021 0.018 0.039 0.036 0.024 0.041 0.04 0.053 0.036 0.057 0.039 0.083 0.038 0.04 0.051 0.035 0.034 0.028 0.05 0.063 0.041 0.039 0.072 0.041 0.035 0.036 0.1 0.069 0.05 0.043 0.027 0.027 0.028 0.027 - 0.034 0.031 0.03 0.028 0.027 0.038 0.037 0.043 0.05 0.053 0.042 0.046 0.045 0.056 0.045 0.078 0.044 0.042 0.037 Carnitine 10.5 14.8 14 11.2 9.57 10 13.8 7.06 9.11 7.12 6.34 13.2 8.62 7.41 6.64 5.63 7.46 8.82 8.46 8.76 10.2 10.8 13.7 7.59 8.72 12.2 10.5 7.56 6.6 6.77 6.2 6.7 8.35 5.57 11 11 13.8 11.2 8.07 12.3 12.6 7.04 7.61 16.5 10.7 9.76 8.09 10.3 8.8 7.55 10.2 8.59 12 7.75 11.9 10.6 6.59 9.04 10 7.96 5.44 4.63 7.6 4.82 5.63 5.28 4.38 9.03 5.76 4.91 7.71 4.6 7.12 7.61 9.51 11.4 9.48 8.35 13.9 10.9 9.7 17.1 19.6 5.58 13.4 15.9 15.3 4.76 5.81 10.7 5.03 11 8.22 11.8 12 10.7 7.99 4.62 12.3 9.61 8.01 14.2 13.8 11.9 13.5 14.5 18 10.3 11.5 10.5 15.4 7.09 6.3 11 6.81 4.86 7.58 9.11 14 8.94 7.81 12.5 11.2 11 12.5 37.3 34.6 32.5 33 25.6 27.3 34 20.5 17 7.07 33 17.7 19.8 14.5 20.1 10.3 14.5 5.1 20.7 13.7 14.7 46 10.6 20.4 15.2 14.1 21.8 10.5 28.9 18.2 11.4 27.5 12.9 18.5 15.6 8.45 18.2 10.3 19.7 18.8 9.28 15.6 31.9 10.9 21.9 18 26.7 48.2 56.4 45 25.2 52.3 65 55 48 51.4 40 52.1 47.9 49.1 47.7 13.4 39.3 41.3 43.6 27.6 30.4 49.2 34.8 52 41.1 32.2 28.9 55.6 51.1 50.2 53.6 28.4 44.1 59.2 46.9 66.7 47.6 28.4 66.7 74.6 77.4 38.5 33.9 26.6 26.5 34.2 41.3 44.1 41.9 22 24.1 22.9 27.5 88.1 80 95.2 86 69.7 50.2 86 84.5 60.6 82.8 90.8 88.4 100 105 83.6 84.4 90.2 64.2 64.1 79.2 108 69.7 106 94.3 Hydroxyoctadecenoic acid 0.003 0.002 0.005 0.007 0.004 0.004 0.003 0.004 0.004 0.004 0.005 0.003 0.004 0.004 0.003 0.005 0.004 0.004 0.004 0.005 0.004 0.005 0.007 0.005 0.01 0.004 0.004 0.011 0.003 0.017 0.005 0.013 0.015 0.004 0.003 0.006 0.003 0.004 0.006 0.003 0.004 0.008 0.005 0.003 0.006 0.005 0.016 0.002 0.002 0.006 0.007 0.003 0.003 0.003 0.005 0.004 0.003 0.005 0.003 0.002 0.003 0.01 0.003 0.003 0.003 0.003 0.002 0.005 0.003 0.003 0.003 0.003 0.004 0.004 0.004 0.004 0.005 0.004 0.003 0.003 0.004 0.003 0.003 0.012 0.003 0.004 0.002 0.004 0.01 0.008 0.006 0.004 0.007 0.004 0.004 0.003 0.003 0.007 0.01 0.013 0.005 0.006 0.003 0.003 0.004 0.003 0.004 0.005 0.003 0.003 0.004 0.008 0.007 0.005 0.005 0.004 0.006 0.006 0.004 0.004 0.002 0.003 0.005 0.005 0.005 0.013 0.013 0.02 0.013 0.008 0.011 0.011 0.017 0.017 0.009 0.018 0.013 0.019 0.009 0.017 0.013 0.016 0.006 0.016 0.01 0.014 0.018 0.01 0.02 0.012 0.015 0.024 0.013 0.02 0.013 0.013 0.019 0.008 0.01 0.009 0.007 0.015 0.012 0.01 0.01 0.008 0.009 0.013 0.006 0.02 0.014 0.081 0.018 0.025 0.038 0.018 0.033 0.028 0.023 0.04 0.035 0.028 0.041 0.034 0.022 0.024 0.011 0.025 0.027 0.021 0.019 0.03 0.028 0.022 0.018 0.023 0.018 0.026 0.02 0.038 0.02 0.024 0.018 0.021 0.037 0.022 0.025 0.022 0.023 0.025 0.025 0.022 0.032 0.017 0.027 0.022 0.016 0.032 0.015 0.02 0.047 0.022 0.019 0.014 0.045 0.03 0.025 0.049 0.03 0.044 0.054 0.066 0.056 0.038 0.049 0.064 0.068 0.076 0.064 0.068 0.088 0.058 0.06 0.077 0.048 0.065 0.049 0.062 Iso-C4 0.058 0.104 0.247 0.106 0.082 0.106 0.051 0.109 0.235 0.056 0.055 0.152 0.041 0.065 0.08 0.098 0.098 0.074 0.081 0.126 0.066 0.064 0.188 0.043 0.046 0.138 0.124 0.121 0.066 0.069 0.043 0.073 0.189 0.042 0.143 0.057 0.086 0.059 0.047 0.056 0.098 0.046 0.143 0.235 0.066 0.094 0.084 0.135 0.045 0.071 0.088 0.08 0.068 0.062 0.08 0.081 0.064 0.055 0.091 0.05 0.051 0.066 0.038 0.051 0.043 0.042 0.04 0.097 0.05 0.046 0.035 0.046 0.052 0.046 0.075 0.1 0.055 0.054 0.093 0.066 0.069 0.094 0.114 0.077 0.07 0.106 0.052 0.027 0.05 0.075 0.04 0.139 0.051 0.051 0.08 0.131 0.136 0.061 0.121 0.077 0.058 0.297 0.154 0.187 0.119 0.079 0.196 0.085 0.075 0.273 0.159 0.044 0.074 0.074 0.074 0.184 0.066 0.065 0.081 0.08 0.043 0.178 0.064 0.078 0.094 1.74 1.75 1.12 0.999 1.11 0.534 1.68 0.507 0.456 0.329 1.4 0.387 0.522 0.605 0.492 0.261 0.256 0.181 0.802 0.672 0.392 1.35 0.128 0.64 0.266 0.377 0.46 0.481 1.43 0.619 0.319 0.741 0.531 0.779 0.271 0.313 0.226 0.635 0.604 1.05 0.369 0.39 0.289 0.661 0.545 0.415 0.788 0.144 0.24 0.102 0.784 0.139 0.169 0.12 0.133 0.17 0.095 0.239 0.182 0.159 0.188 0.559 0.071 0.055 0.048 0.075 0.091 0.081 0.064 0.074 0.065 0.131 0.426 0.046 0.115 0.117 0.114 0.08 0.058 0.086 0.12 0.153 0.061 1.22 0.058 0.089 0.085 1.22 1.05 0.536 0.589 0.902 0.837 1.09 1.22 0.575 0.82 1.13 0.812 0.311 0.232 0.222 0.333 0.594 0.275 0.42 0.588 0.353 0.264 0.211 0.361 0.34 0.286 0.261 0.298 0.247 0.181 0.237 0.171 0.448 0.235 0.361 0.299 Iso-C5 0.049 0.047 0.045 0.05 0.035 0.045 0.052 0.052 0.088 0.042 0.047 0.051 0.045 0.037 0.039 0.068 0.037 0.051 0.043 0.059 0.045 0.049 0.033 0.029 0.049 0.034 0.051 0.09 0.042 0.05 0.044 0.056 0.059 0.024 0.028 0.046 0.044 0.042 0.043 0.055 0.072 0.062 0.027 0.048 0.059 0.052 0.054 0.037 0.027 0.035 0.06 0.031 0.056 0.024 0.046 0.043 0.023 0.037 0.043 0.03 0.035 0.023 0.024 0.022 0.019 0.021 0.02 0.033 0.025 0.026 0.022 0.022 0.036 0.03 0.059 0.057 0.038 0.04 0.042 0.036 0.044 0.071 0.037 0.047 0.051 0.065 0.04 0.014 0.026 0.039 0.023 0.042 0.025 0.042 0.041 0.065 0.057 0.023 0.131 0.064 0.038 0.103 0.059 0.059 0.111 0.062 0.092 0.083 0.038 0.053 0.075 0.042 0.052 0.094 0.061 0.039 0.066 0.099 0.092 0.074 0.034 0.142 0.084 0.084 0.116 0.296 0.31 0.16 0.147 0.228 0.15 0.284 0.168 0.215 0.171 0.324 0.179 0.214 0.176 0.192 0.117 0.083 0.108 0.316 0.258 0.139 0.157 0.076 0.284 0.109 0.171 0.204 0.222 0.71 0.199 0.124 0.16 0.124 0.218 0.096 0.118 0.105 0.195 0.162 0.34 0.161 0.158 0.068 0.154 0.19 0.208 0.189 0.092 0.246 0.056 0.131 0.075 0.102 0.058 0.083 0.094 0.054 0.145 0.103 0.118 0.13 0.134 0.066 0.048 0.034 0.064 0.071 0.065 0.042 0.059 0.055 0.056 0.106 0.041 0.093 0.094 0.04 0.076 0.041 0.056 0.066 0.114 0.041 0.285 0.045 0.056 0.043 0.254 0.213 0.125 0.088 0.232 0.219 0.215 0.279 0.134 0.23 0.235 0.166 0.172 0.154 0.122 0.28 0.454 0.206 0.405 0.437 0.239 0.127 0.2 0.332 0.241 0.208 0.171 0.308 0.174 0.152 0.209 0.165 0.339 0.241 0.25 0.184 Tetradecadienoic acid 0.016 0.015 0.019 0.028 0.014 0.018 0.015 0.014 0.028 0.024 0.024 0.018 0.025 0.031 0.023 0.03 0.028 0.024 0.029 0.031 0.022 0.023 0.021 0.019 0.041 0.019 0.028 0.047 0.02 0.043 0.025 0.04 0.035 0.018 0.022 0.027 0.025 0.023 0.028 0.024 0.028 0.043 0.021 0.018 0.033 0.035 0.05 0.01 0.014 0.024 0.037 0.018 0.02 0.013 0.022 0.023 0.015 0.021 0.024 0.016 0.017 0.023 0.018 0.017 0.014 0.017 0.016 0.026 0.019 0.015 0.013 0.017 0.026 0.022 0.026 0.031 0.028 0.024 0.018 0.02 0.027 0.024 0.038 0.033 0.025 0.028 0.023 0.016 0.028 0.023 0.022 0.023 0.032 0.028 0.026 0.022 0.031 0.036 0.046 0.038 0.029 0.029 0.022 0.02 0.037 0.02 0.025 0.022 0.016 0.015 0.028 0.03 0.037 0.034 0.029 0.017 0.034 0.045 0.035 0.034 0.032 0.037 0.039 0.039 0.04 0.032 0.024 0.024 0.023 0.021 0.017 0.022 0.014 0.036 0.013 0.025 0.022 0.024 0.012 0.022 0.019 0.021 0.013 0.023 0.017 0.019 0.023 0.026 0.029 0.027 0.039 0.034 0.016 0.045 0.031 0.02 0.034 0.025 0.035 0.028 0.011 0.027 0.023 0.012 0.022 0.02 0.023 0.022 0.019 0.029 0.024 0.04 0.027 0.051 0.037 0.035 0.044 0.034 0.032 0.05 0.048 0.04 0.047 0.042 0.038 0.064 0.027 0.059 0.057 0.047 0.063 0.075 0.081 0.059 0.057 0.052 0.056 0.024 0.046 0.087 0.06 0.074 0.065 0.053 0.064 0.079 0.061 0.066 0.04 0.035 0.05 0.06 0.056 0.04 0.028 0.03 0.033 0.036 0.038 0.039 0.036 0.047 0.034 0.033 0.049 0.06 0.028 0.04 0.04 0.05 0.103 0.073 0.04 0.038 0.065 0.108 0.064 0.113 0.075 0.084 0.064 0.071 0.065 0.042 0.088 0.073 0.1 0.074 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name HMDB PubChem KEGG C4-2M NA NA NA C8-DC NA NA NA CAR 10:0 NA NA NA CAR 12:0 NA NA NA CAR 12:0;OH NA NA NA CAR 14:0 NA NA NA CAR 16:0 NA NA NA CAR 16:0;OH NA NA NA CAR 16:1;OH NA NA NA CAR 18:0 NA NA NA CAR 18:0;OH NA NA NA CAR 18:1 NA NA NA CAR 18:2 NA NA NA CAR 2:0 NA 18230 NA CAR 20:4 NA NA NA CAR 3:0 NA NA NA CAR 4:0 HMDB0002013 439829 C02862 CAR 4:0;OH NA NA NA CAR 5:0 NA NA NA CAR 5:1 NA NA NA CAR 6:0 NA NA NA CAR 6:0;OH NA NA NA CAR 8:0 NA NA NA CAR DC3:0 NA NA NA CAR DC4:0 NA 71464481 NA CAR DC5:0 NA 53481622 NA CAR DC5:0;3Me NA NA NA Carnitine HMDB0000062 10917 C00318 Hydroxyoctadecenoic acid NA NA NA Iso-C4 NA NA NA Iso-C5 NA NA NA Tetradecadienoic acid NA NA NA METABOLITES_END #END