#METABOLOMICS WORKBENCH Lamichhane_20211101_045243 DATATRACK_ID:2914 STUDY_ID:ST001991 ANALYSIS_ID:AN003248 PROJECT_ID:PR001265 VERSION 1 CREATED_ON November 16, 2021, 9:27 am #PROJECT PR:PROJECT_TITLE Dynamics of bile acid metabolism between the host and gut microbiome in PR:PROJECT_TITLE progression to islet autoimmunity PR:PROJECT_TYPE MS analysis PR:PROJECT_SUMMARY Here, we analyzed BAs in a longitudinal series of serum (n= 333) collected at 3, PR:PROJECT_SUMMARY 6, 12, 18, 24 and 36 months of age, from children who developed a single islet PR:PROJECT_SUMMARY autoantibody (P1Ab), multiple islet autoantibodies (P2Ab), and controls (CTRs) PR:PROJECT_SUMMARY who remained autoantibody (AAb) negative during the follow-up. PR:INSTITUTE University of Turku PR:DEPARTMENT University of Turku PR:LABORATORY Turku Metabolomics Center PR:LAST_NAME Lamichhane PR:FIRST_NAME Santosh PR:ADDRESS Yo Kylä 30A 5 PR:EMAIL santosh.lamichhane@utu.fi PR:PHONE 0452299070 PR:FUNDING_SOURCE Academy of Finland postdoctoral grant (No. 323171 to S.L.), the Novo Nordisk PR:FUNDING_SOURCE Foundation (Grant no. NNF20OC0063971 to T.H. and M.O.) PR:PROJECT_COMMENTS Part 1 Serum data for DIABIMMUNE study. Please put this study and Data track ID PR:PROJECT_COMMENTS into one project 2930. PR:CONTRIBUTORS Santosh Lamichhane, Partho Sen, Alex M. Dickens, Marina Amaral Alves, Taina PR:CONTRIBUTORS Härkönen, Jarno Honkanen, Tommi Vatanen, Ramnik J. Xavier, Tuulia PR:CONTRIBUTORS Hyötyläinen, Mikael Knip4,, Matej Oresic #STUDY ST:STUDY_TITLE Dynamics of bile acid metabolism between the host and gut microbiome in ST:STUDY_TITLE progression to islet autoimmunity (Blood) ST:STUDY_SUMMARY Previous studies suggest that the human gut microbiome is dysregulated in islet ST:STUDY_SUMMARY autoimmunity, preceding the clinical onset of type 1 diabetes (T1D). The Gut ST:STUDY_SUMMARY microbiota of the gut plays an important role in the regulation of bile acid ST:STUDY_SUMMARY (BA) metabolism. However, not much is known about the regulation of BAs during ST:STUDY_SUMMARY progression to T1D. Here, we analyzed BAs in a longitudinal series of serum (n= ST:STUDY_SUMMARY 333) and stool (n= 304) samples, collected at 3, 6, 12, 18, 24 and 36 months of ST:STUDY_SUMMARY age, from children who developed a single islet autoantibody (P1Ab), multiple ST:STUDY_SUMMARY islet autoantibodies (P2Ab), and controls (CTRs) who remained autoantibody (AAb) ST:STUDY_SUMMARY negative during the follow-up. In addition, we analyzed the stool microbiome by ST:STUDY_SUMMARY shotgun metagenomics in a subgroup of these children (n=111). Factor analysis ST:STUDY_SUMMARY showed that age had the strongest impact on BA and microbiome profiles. We found ST:STUDY_SUMMARY that, at an early age, the systemic BA (including taurine and glycine ST:STUDY_SUMMARY conjugates) and microbial secondary BA pathways were altered in the P2Ab group ST:STUDY_SUMMARY as compared to the P1Ab or CTR groups. Our findings thus suggest that ST:STUDY_SUMMARY dysregulated BA metabolism in early life may contribute to the risk and ST:STUDY_SUMMARY pathogenesis of T1D. ST:INSTITUTE University of Turku ST:DEPARTMENT University of Turku ST:LABORATORY Turku Metabolomics Center ST:LAST_NAME Lamichhane ST:FIRST_NAME Santosh ST:ADDRESS Yo Kylä 30A 6 ST:EMAIL santosh.lamichhane@utu.fi ST:PHONE 0452299070 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:GENDER Male and female #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 461 5000016 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000016.mzML SUBJECT_SAMPLE_FACTORS 94 5000018 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5000018.mzML SUBJECT_SAMPLE_FACTORS 461 5000047 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000047.mzML SUBJECT_SAMPLE_FACTORS 3950 5000049 Age:3 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5000049.mzML SUBJECT_SAMPLE_FACTORS 94 5000061 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5000061.mzML SUBJECT_SAMPLE_FACTORS 4341 5000069 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5000069.mzML SUBJECT_SAMPLE_FACTORS 3355 5000075 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5000075.mzML SUBJECT_SAMPLE_FACTORS 5643 5000089 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5000089.mzML SUBJECT_SAMPLE_FACTORS 3353 5000112 Age:6 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000112.mzML SUBJECT_SAMPLE_FACTORS 4341 5000122 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000122.mzML SUBJECT_SAMPLE_FACTORS 10532 5000153 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5000153.mzML SUBJECT_SAMPLE_FACTORS 5643 5000291 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5000291.mzML SUBJECT_SAMPLE_FACTORS 28183 5000292 Age:6 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5000292.mzML SUBJECT_SAMPLE_FACTORS 16812 5000306 Age:12 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5000306.mzML SUBJECT_SAMPLE_FACTORS 94 5000318 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5000318.mzML SUBJECT_SAMPLE_FACTORS 16834 5000336 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5000336.mzML SUBJECT_SAMPLE_FACTORS 2534 5000376 Age:24 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5000376.mzML SUBJECT_SAMPLE_FACTORS 19852 5000381 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5000381.mzML SUBJECT_SAMPLE_FACTORS 19853 5000388 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5000388.mzML SUBJECT_SAMPLE_FACTORS 10532 5000396 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5000396.mzML SUBJECT_SAMPLE_FACTORS 2473 5000419 Age:3 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5000419.mzML SUBJECT_SAMPLE_FACTORS 3251 5000437 Age:3 | sex:1 | Case:P2Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000437.mzML SUBJECT_SAMPLE_FACTORS 3989 5000439 Age:3 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5000439.mzML SUBJECT_SAMPLE_FACTORS 3061 5000443 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=02082019Plate9BA-5000443.mzML SUBJECT_SAMPLE_FACTORS 5804 5000468 Age:3 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5000468.mzML SUBJECT_SAMPLE_FACTORS 6574 5000484 Age:3 | sex:2 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5000484.mzML SUBJECT_SAMPLE_FACTORS 2473 5000486 Age:6 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5000486.mzML SUBJECT_SAMPLE_FACTORS 6646 5000492 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5000492.mzML SUBJECT_SAMPLE_FACTORS 7743 5000505 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5000505.mzML SUBJECT_SAMPLE_FACTORS 7980 5000512 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000512.mzML SUBJECT_SAMPLE_FACTORS 3989 5000514 Age:6 | sex:2 | Case:P2Ab RAW_FILE_NAME=29072019_Bile_Acid_Rerun_Plate_7&part8-5000514.mzML SUBJECT_SAMPLE_FACTORS 8643 5000525 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5000525.mzML SUBJECT_SAMPLE_FACTORS 3061 5000526 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5000526.mzML SUBJECT_SAMPLE_FACTORS 9667 5000544 Age:3 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5000544.mzML SUBJECT_SAMPLE_FACTORS 3251 5000545 Age:6 | sex:1 | Case:P2Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000545.mzML SUBJECT_SAMPLE_FACTORS 10590 5000570 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5000570.mzML SUBJECT_SAMPLE_FACTORS 10937 5000577 Age:3 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5000577.mzML SUBJECT_SAMPLE_FACTORS 5804 5000580 Age:6 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5000580.mzML SUBJECT_SAMPLE_FACTORS 6574 5000595 Age:6 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5000595.mzML SUBJECT_SAMPLE_FACTORS 6646 5000599 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5000599.mzML SUBJECT_SAMPLE_FACTORS 13487 5000608 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5000608.mzML SUBJECT_SAMPLE_FACTORS 7980 5000633 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5000633.mzML SUBJECT_SAMPLE_FACTORS 8643 5000648 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5000648.mzML SUBJECT_SAMPLE_FACTORS 9667 5000667 Age:6 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5000667.mzML SUBJECT_SAMPLE_FACTORS 15378 5000674 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000674.mzML SUBJECT_SAMPLE_FACTORS 15991 5000683 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5000683.mzML SUBJECT_SAMPLE_FACTORS 10590 5000692 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5000692.mzML SUBJECT_SAMPLE_FACTORS 10937 5000693 Age:6 | sex:1 | Case:P2Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5000693.mzML SUBJECT_SAMPLE_FACTORS 16924 5000713 Age:3 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5000713.mzML SUBJECT_SAMPLE_FACTORS 2473 5000718 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=02082019Plate8_restarted-5000718.mzML SUBJECT_SAMPLE_FACTORS 2338 5000722 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=29072019_Bile_Acid_Rerun_Plate_7&part8-5000722.mzML SUBJECT_SAMPLE_FACTORS 12678 5000732 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5000732.mzML SUBJECT_SAMPLE_FACTORS 17833 5000745 Age:3 | sex:1 | Case:P1Ab 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RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5001097.mzML SUBJECT_SAMPLE_FACTORS 11676 5001108 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5001108.mzML SUBJECT_SAMPLE_FACTORS 12808 5001127 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001127.mzML SUBJECT_SAMPLE_FACTORS 23390 5001132 Age:6 | sex:1 | Case:P1Ab RAW_FILE_NAME=02082019Plate8_restarted-5001132.mzML SUBJECT_SAMPLE_FACTORS 13815 5001145 Age:12 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5001145.mzML SUBJECT_SAMPLE_FACTORS 12374 5001159 Age:12 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5001164.mzML SUBJECT_SAMPLE_FACTORS 12983 5001164 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5001174.mzML SUBJECT_SAMPLE_FACTORS 14197 5001174 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5001176.mzML SUBJECT_SAMPLE_FACTORS 25411 5001176 Age:6 | sex:1 | Case:CTR 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RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001288.mzML SUBJECT_SAMPLE_FACTORS 3353 5001288 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5001293.mzML SUBJECT_SAMPLE_FACTORS 21076 5001293 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=02082019Plate8_restarted-5001295.mzML SUBJECT_SAMPLE_FACTORS 12121 5001295 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5001298.mzML SUBJECT_SAMPLE_FACTORS 3355 5001298 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001302.mzML SUBJECT_SAMPLE_FACTORS 13828 5001302 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5001308.mzML SUBJECT_SAMPLE_FACTORS 12808 5001308 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5001318.mzML SUBJECT_SAMPLE_FACTORS 23390 5001318 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5001324.mzML SUBJECT_SAMPLE_FACTORS 12374 5001324 Age:18 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001325.mzML SUBJECT_SAMPLE_FACTORS 4341 5001325 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5001329.mzML SUBJECT_SAMPLE_FACTORS 3950 5001329 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5001336.mzML SUBJECT_SAMPLE_FACTORS 13815 5001336 Age:18 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5001342.mzML SUBJECT_SAMPLE_FACTORS 12138 5001342 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5001354.mzML SUBJECT_SAMPLE_FACTORS 25411 5001354 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001358.mzML SUBJECT_SAMPLE_FACTORS 5643 5001358 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5001361.mzML SUBJECT_SAMPLE_FACTORS 12983 5001361 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5001362.mzML SUBJECT_SAMPLE_FACTORS 25418 5001362 Age:12 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5001365.mzML SUBJECT_SAMPLE_FACTORS 14197 5001365 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5001373.mzML SUBJECT_SAMPLE_FACTORS 14800 5001373 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5001389.mzML SUBJECT_SAMPLE_FACTORS 16812 5001389 Age:18 | sex:1 | Case:P2Ab RAW_FILE_NAME=02082019Plate8_restarted-5001401.mzML SUBJECT_SAMPLE_FACTORS 28183 5001401 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5001433.mzML SUBJECT_SAMPLE_FACTORS 16834 5001433 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5001459.mzML SUBJECT_SAMPLE_FACTORS 10532 5001457 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5001462.mzML SUBJECT_SAMPLE_FACTORS 19852 5001459 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001472.mzML SUBJECT_SAMPLE_FACTORS 19853 5001462 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5001482.mzML SUBJECT_SAMPLE_FACTORS 21076 5001472 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5001489.mzML SUBJECT_SAMPLE_FACTORS 12121 5001482 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5001504.mzML SUBJECT_SAMPLE_FACTORS 12374 5001489 Age:24 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001519.mzML SUBJECT_SAMPLE_FACTORS 25411 5001504 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5001524.mzML SUBJECT_SAMPLE_FACTORS 12138 5001519 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5001530.mzML SUBJECT_SAMPLE_FACTORS 23390 5001524 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5001535.mzML SUBJECT_SAMPLE_FACTORS 14197 5001530 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5001536.mzML SUBJECT_SAMPLE_FACTORS 12808 5001535 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5001562.mzML SUBJECT_SAMPLE_FACTORS 14800 5001536 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5001563.mzML SUBJECT_SAMPLE_FACTORS 28183 5001562 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5001577.mzML SUBJECT_SAMPLE_FACTORS 94 5001563 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5001584.mzML SUBJECT_SAMPLE_FACTORS 16834 5001577 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5001591.mzML SUBJECT_SAMPLE_FACTORS 16812 5001584 Age:24 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5001679.mzML SUBJECT_SAMPLE_FACTORS 461 5001591 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5001837.mzML SUBJECT_SAMPLE_FACTORS 2473 5001679 Age:36 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5001858.mzML SUBJECT_SAMPLE_FACTORS 26325 5001740 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5001903.mzML SUBJECT_SAMPLE_FACTORS 5804 5001837 Age:36 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5001908.mzML SUBJECT_SAMPLE_FACTORS 26079 5001858 Age:24 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5001928.mzML SUBJECT_SAMPLE_FACTORS 8643 5001903 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001942.mzML SUBJECT_SAMPLE_FACTORS 7303 5001908 Age:36 | sex:2 | Case:P1Ab RAW_FILE_NAME=02082019Plate8_restarted-5001952.mzML SUBJECT_SAMPLE_FACTORS 7743 5001928 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5001991.mzML SUBJECT_SAMPLE_FACTORS 10937 5001942 Age:36 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5001992.mzML SUBJECT_SAMPLE_FACTORS 7980 5001952 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5002506.mzML SUBJECT_SAMPLE_FACTORS 33156 5001991 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002517.mzML SUBJECT_SAMPLE_FACTORS 31941 5001992 Age:24 | sex:2 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002523.mzML SUBJECT_SAMPLE_FACTORS 19187 5002506 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5002538.mzML SUBJECT_SAMPLE_FACTORS 3989 5002517 Age:12 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5002549.mzML SUBJECT_SAMPLE_FACTORS 19349 5002523 Age:3 | sex:2 | Case:P1Ab RAW_FILE_NAME=02082019Plate8_restarted-5002564.mzML SUBJECT_SAMPLE_FACTORS 15991 5002538 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5002566.mzML SUBJECT_SAMPLE_FACTORS 3061 5002549 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5002571.mzML SUBJECT_SAMPLE_FACTORS 15378 5002564 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5002577.mzML SUBJECT_SAMPLE_FACTORS 4934 5002566 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002582.mzML SUBJECT_SAMPLE_FACTORS 20682 5002571 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5002583.mzML SUBJECT_SAMPLE_FACTORS 20808 5002577 Age:3 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5002586.mzML SUBJECT_SAMPLE_FACTORS 16148 5002582 Age:6 | sex:1 | Case:P2Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002593.mzML SUBJECT_SAMPLE_FACTORS 20781 5002583 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5002601.mzML SUBJECT_SAMPLE_FACTORS 6574 5002586 Age:12 | sex:2 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5002608.mzML SUBJECT_SAMPLE_FACTORS 22852 5002593 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5002644.mzML SUBJECT_SAMPLE_FACTORS 5804 5002601 Age:12 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5002651.mzML SUBJECT_SAMPLE_FACTORS 6646 5002608 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5002656.mzML SUBJECT_SAMPLE_FACTORS 24213 5002644 Age:3 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5002677.mzML SUBJECT_SAMPLE_FACTORS 17751 5002651 Age:6 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5002678.mzML SUBJECT_SAMPLE_FACTORS 23535 5002656 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002708.mzML SUBJECT_SAMPLE_FACTORS 23681 5002677 Age:3 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5002711.mzML SUBJECT_SAMPLE_FACTORS 17833 5002678 Age:6 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5002721.mzML SUBJECT_SAMPLE_FACTORS 7743 5002708 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5002726.mzML SUBJECT_SAMPLE_FACTORS 25671 5002711 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002733.mzML SUBJECT_SAMPLE_FACTORS 7980 5002721 Age:12 | sex:2 | Case:CTR 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RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002837.mzML SUBJECT_SAMPLE_FACTORS 19349 5002832 Age:6 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5002853.mzML SUBJECT_SAMPLE_FACTORS 20808 5002833 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002864.mzML SUBJECT_SAMPLE_FACTORS 20682 5002837 Age:6 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5002884.mzML SUBJECT_SAMPLE_FACTORS 20781 5002853 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5002888.mzML SUBJECT_SAMPLE_FACTORS 22852 5002864 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate9BA-5002890.mzML SUBJECT_SAMPLE_FACTORS 12678 5002884 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002920.mzML SUBJECT_SAMPLE_FACTORS 2338 5002888 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5002923.mzML SUBJECT_SAMPLE_FACTORS 30933 5002890 Age:3 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002933.mzML SUBJECT_SAMPLE_FACTORS 2473 5002920 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=02082019Plate8_restarted-5002960.mzML SUBJECT_SAMPLE_FACTORS 10937 5002923 Age:12 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5002961.mzML SUBJECT_SAMPLE_FACTORS 10590 5002931 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5002975.mzML SUBJECT_SAMPLE_FACTORS 23535 5002933 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5002979.mzML SUBJECT_SAMPLE_FACTORS 3061 5002960 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5002998.mzML SUBJECT_SAMPLE_FACTORS 24646 5002961 Age:6 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5003521.mzML SUBJECT_SAMPLE_FACTORS 3251 5002975 Age:18 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5003523.mzML SUBJECT_SAMPLE_FACTORS 26079 5002979 Age:6 | sex:2 | Case:P2Ab 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RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004045.mzML SUBJECT_SAMPLE_FACTORS 4016 5004013 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5004051.mzML SUBJECT_SAMPLE_FACTORS 25671 5004026 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5004073.mzML SUBJECT_SAMPLE_FACTORS 3989 5004036 Age:18 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004075.mzML SUBJECT_SAMPLE_FACTORS 33156 5004045 Age:3 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5004081.mzML SUBJECT_SAMPLE_FACTORS 4934 5004051 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5004085.mzML SUBJECT_SAMPLE_FACTORS 6574 5004073 Age:18 | sex:2 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004088.mzML SUBJECT_SAMPLE_FACTORS 16148 5004075 Age:12 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004092.mzML SUBJECT_SAMPLE_FACTORS 30933 5004081 Age:6 | sex:1 | Case:P1Ab RAW_FILE_NAME=02082019Plate9BA-5004095.mzML SUBJECT_SAMPLE_FACTORS 15378 5004085 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5004102.mzML SUBJECT_SAMPLE_FACTORS 15991 5004088 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5004115.mzML SUBJECT_SAMPLE_FACTORS 5804 5004092 Age:18 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004124.mzML SUBJECT_SAMPLE_FACTORS 16924 5004095 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5004139.mzML SUBJECT_SAMPLE_FACTORS 17751 5004102 Age:12 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004143.mzML SUBJECT_SAMPLE_FACTORS 6646 5004115 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004146.mzML SUBJECT_SAMPLE_FACTORS 7303 5004124 Age:18 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004149.mzML SUBJECT_SAMPLE_FACTORS 7743 5004139 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004155.mzML SUBJECT_SAMPLE_FACTORS 8643 5004143 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004158.mzML SUBJECT_SAMPLE_FACTORS 31941 5004146 Age:6 | sex:2 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5004162.mzML SUBJECT_SAMPLE_FACTORS 7980 5004149 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5004166.mzML SUBJECT_SAMPLE_FACTORS 18574 5004155 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=29072019_Bile_Acid_Rerun_Plate_7&part8-5004170.mzML SUBJECT_SAMPLE_FACTORS 18113 5004158 Age:12 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5004176.mzML SUBJECT_SAMPLE_FACTORS 10937 5004162 Age:18 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5004186.mzML SUBJECT_SAMPLE_FACTORS 23535 5004166 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5004189.mzML SUBJECT_SAMPLE_FACTORS 9667 5004170 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5004192.mzML SUBJECT_SAMPLE_FACTORS 10590 5004176 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004195.mzML SUBJECT_SAMPLE_FACTORS 19187 5004186 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5004197.mzML SUBJECT_SAMPLE_FACTORS 19349 5004189 Age:12 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004207.mzML SUBJECT_SAMPLE_FACTORS 33156 5004192 Age:6 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004229.mzML SUBJECT_SAMPLE_FACTORS 20808 5004195 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5004277.mzML SUBJECT_SAMPLE_FACTORS 20682 5004197 Age:12 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5004285.mzML SUBJECT_SAMPLE_FACTORS 24213 5004207 Age:12 | sex:2 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004292.mzML SUBJECT_SAMPLE_FACTORS 20781 5004229 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004293.mzML SUBJECT_SAMPLE_FACTORS 2338 5004277 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5004303.mzML SUBJECT_SAMPLE_FACTORS 23681 5004285 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5004323.mzML SUBJECT_SAMPLE_FACTORS 24646 5004292 Age:12 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004324.mzML SUBJECT_SAMPLE_FACTORS 3061 5004293 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5004334.mzML SUBJECT_SAMPLE_FACTORS 25671 5004303 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5004373.mzML SUBJECT_SAMPLE_FACTORS 26079 5004323 Age:12 | sex:2 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5004379.mzML SUBJECT_SAMPLE_FACTORS 13487 5004324 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004385.mzML SUBJECT_SAMPLE_FACTORS 26325 5004334 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5004386.mzML SUBJECT_SAMPLE_FACTORS 2473 5004373 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5004390.mzML SUBJECT_SAMPLE_FACTORS 30933 5004379 Age:12 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5004400.mzML SUBJECT_SAMPLE_FACTORS 4934 5004385 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5004406.mzML SUBJECT_SAMPLE_FACTORS 15378 5004386 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=29072019_Bile_Acid_Rerun_Plate_7&part8-5004416.mzML SUBJECT_SAMPLE_FACTORS 16148 5004390 Age:18 | sex:1 | Case:P2Ab RAW_FILE_NAME=02082019Plate8_restarted-5004417.mzML SUBJECT_SAMPLE_FACTORS 15991 5004400 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5004428.mzML SUBJECT_SAMPLE_FACTORS 4016 5004404 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004430.mzML SUBJECT_SAMPLE_FACTORS 6646 5004406 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5004443.mzML SUBJECT_SAMPLE_FACTORS 17833 5004416 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5004494.mzML SUBJECT_SAMPLE_FACTORS 5804 5004417 Age:24 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005537.mzML SUBJECT_SAMPLE_FACTORS 7303 5004428 Age:24 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005538.mzML SUBJECT_SAMPLE_FACTORS 17751 5004430 Age:18 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5005548.mzML SUBJECT_SAMPLE_FACTORS 7743 5004443 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5005552.mzML SUBJECT_SAMPLE_FACTORS 20781 5004494 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5005553.mzML SUBJECT_SAMPLE_FACTORS 3989 5005537 Age:24 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5005559.mzML SUBJECT_SAMPLE_FACTORS 12678 5005538 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5005569.mzML SUBJECT_SAMPLE_FACTORS 18574 5005548 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5005577.mzML SUBJECT_SAMPLE_FACTORS 31941 5005552 Age:12 | sex:2 | Case:P1Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5005639.mzML SUBJECT_SAMPLE_FACTORS 8643 5005553 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5005652.mzML SUBJECT_SAMPLE_FACTORS 7980 5005559 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005654.mzML SUBJECT_SAMPLE_FACTORS 18113 5005569 Age:18 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5005655.mzML SUBJECT_SAMPLE_FACTORS 19187 5005577 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005656.mzML SUBJECT_SAMPLE_FACTORS 33156 5005639 Age:12 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5005659.mzML SUBJECT_SAMPLE_FACTORS 20808 5005652 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005660.mzML SUBJECT_SAMPLE_FACTORS 22852 5005654 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5005667.mzML SUBJECT_SAMPLE_FACTORS 9667 5005655 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5005682.mzML SUBJECT_SAMPLE_FACTORS 10937 5005656 Age:24 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5005699.mzML SUBJECT_SAMPLE_FACTORS 10590 5005659 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5005708.mzML SUBJECT_SAMPLE_FACTORS 19349 5005660 Age:18 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5005728.mzML SUBJECT_SAMPLE_FACTORS 22137 5005667 Age:18 | sex:2 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5005746.mzML SUBJECT_SAMPLE_FACTORS 23681 5005682 Age:18 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5005766.mzML SUBJECT_SAMPLE_FACTORS 23535 5005699 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5005768.mzML SUBJECT_SAMPLE_FACTORS 23681 5005708 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5005774.mzML SUBJECT_SAMPLE_FACTORS 23535 5005728 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5005776.mzML SUBJECT_SAMPLE_FACTORS 18574 5005746 Age:24 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5005793.mzML SUBJECT_SAMPLE_FACTORS 24646 5005766 Age:18 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5005795.mzML SUBJECT_SAMPLE_FACTORS 20682 5005768 Age:18 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5005813.mzML SUBJECT_SAMPLE_FACTORS 25671 5005774 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5005823.mzML SUBJECT_SAMPLE_FACTORS 13487 5005776 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5005832.mzML SUBJECT_SAMPLE_FACTORS 26325 5005793 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5005836.mzML SUBJECT_SAMPLE_FACTORS 16148 5005795 Age:24 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005859.mzML SUBJECT_SAMPLE_FACTORS 6574 5005813 Age:24 | sex:2 | Case:P2Ab RAW_FILE_NAME=29072019_Bile_Acid_Rerun_Plate_7&part8-5005860.mzML SUBJECT_SAMPLE_FACTORS 15991 5005823 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5005863.mzML SUBJECT_SAMPLE_FACTORS 26079 5005832 Age:18 | sex:2 | Case:P2Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5005867.mzML SUBJECT_SAMPLE_FACTORS 15378 5005836 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005880.mzML SUBJECT_SAMPLE_FACTORS 31941 5005859 Age:18 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005905.mzML SUBJECT_SAMPLE_FACTORS 19349 5005860 Age:24 | sex:2 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005927.mzML SUBJECT_SAMPLE_FACTORS 18113 5005863 Age:24 | sex:1 | Case:P2Ab RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5005933.mzML SUBJECT_SAMPLE_FACTORS 25671 5005864 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005937.mzML SUBJECT_SAMPLE_FACTORS 4016 5005867 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5005946.mzML SUBJECT_SAMPLE_FACTORS 18268 5005880 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5005970.mzML SUBJECT_SAMPLE_FACTORS 33156 5005905 Age:18 | sex:2 | Case:CTR RAW_FILE_NAME=26072019_Bile_Acid_Rerun_Plate_7&part8-5005981.mzML SUBJECT_SAMPLE_FACTORS 20682 5005927 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5005982.mzML SUBJECT_SAMPLE_FACTORS 20808 5005933 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5600536.mzML SUBJECT_SAMPLE_FACTORS 19187 5005937 Age:24 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5600656.mzML SUBJECT_SAMPLE_FACTORS 20781 5005946 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=02082019Plate8_restarted-5600666.mzML SUBJECT_SAMPLE_FACTORS 2338 5005970 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5600712.mzML SUBJECT_SAMPLE_FACTORS 22852 5005981 Age:24 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5600751.mzML SUBJECT_SAMPLE_FACTORS 22137 5005982 Age:24 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5600757.mzML SUBJECT_SAMPLE_FACTORS 6574 5600536 Age:36 | sex:2 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5600819.mzML SUBJECT_SAMPLE_FACTORS 15991 5600656 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5600829.mzML SUBJECT_SAMPLE_FACTORS 15378 5600666 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5600873.mzML SUBJECT_SAMPLE_FACTORS 17751 5600712 Age:36 | sex:1 | Case:P2Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5600874.mzML SUBJECT_SAMPLE_FACTORS 17833 5600751 Age:36 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_6-5600881.mzML SUBJECT_SAMPLE_FACTORS 18268 5600757 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5600896.mzML SUBJECT_SAMPLE_FACTORS 19187 5600819 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5600897.mzML SUBJECT_SAMPLE_FACTORS 18113 5600829 Age:36 | sex:1 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_2-5600901.mzML SUBJECT_SAMPLE_FACTORS 22137 5600873 Age:36 | sex:2 | Case:P2Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_1-5600919.mzML SUBJECT_SAMPLE_FACTORS 18574 5600874 Age:36 | sex:1 | Case:P1Ab RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5600956.mzML SUBJECT_SAMPLE_FACTORS 16870 5600881 Age:36 | sex:1 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5600978.mzML SUBJECT_SAMPLE_FACTORS 20781 5600896 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_4-5601111.mzML SUBJECT_SAMPLE_FACTORS 19349 5600897 Age:36 | sex:2 | Case:P1Ab RAW_FILE_NAME=25072019_Bile_Acid_Rerun_Plate_5-5601174.mzML SUBJECT_SAMPLE_FACTORS 20808 5600901 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=21072019_Bile_Acid_Rerun_Plate_3-5601269.mzML SUBJECT_SAMPLE_FACTORS 20682 5600902 Age:36 | sex:1 | Case:CTR RAW_FILE_NAME=20190805_BA_rerun_10-5001159v2.mzML SUBJECT_SAMPLE_FACTORS 22852 5600919 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=20190805_BA_rerun_10-5001457v2.mzML SUBJECT_SAMPLE_FACTORS 23681 5600956 Age:36 | sex:1 | Case:P1Ab RAW_FILE_NAME=20190805_BA_rerun_10-5001740v2.mzML SUBJECT_SAMPLE_FACTORS 26325 5600978 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=20190805_BA_rerun_10-5002931v2.mzML SUBJECT_SAMPLE_FACTORS 30933 5601111 Age:36 | sex:1 | Case:P1Ab RAW_FILE_NAME=20190805_BA_rerun_10-5004404v2.mzML SUBJECT_SAMPLE_FACTORS 33156 5601174 Age:36 | sex:2 | Case:CTR RAW_FILE_NAME=20190805_BA_rerun_10-5005864v2.mzML SUBJECT_SAMPLE_FACTORS 28183 5601269 Age:36 | sex:1 | Case:P1Ab RAW_FILE_NAME=20190805_BA_rerun_10-5600902v2.mzML #COLLECTION CO:COLLECTION_SUMMARY The DIABIMMUNE study recruited 832 families in Finland (Espoo), Estonia (Tartu), CO:COLLECTION_SUMMARY and Russia (Petrozavodsk) with infants carrying HLA alleles that conferred risk CO:COLLECTION_SUMMARY for autoimmunity. The subjects involved in the current study were chosen from CO:COLLECTION_SUMMARY the subset (n = 74) of international DIABIMMUNE study children who progressed to CO:COLLECTION_SUMMARY at least a single AAb (P1Ab, n = 23), who progressed to multiple islet AAb CO:COLLECTION_SUMMARY (P2Ab, n = 13), and controls (CTRs, n = 38), i.e. the children who remained CO:COLLECTION_SUMMARY islet AAb- negative during the follow-up in a longitudinal series of samples CO:COLLECTION_SUMMARY collected at 3, 6, 12, 18, 24 and 36 months from each child (Kostic et al. CO:COLLECTION_SUMMARY 2015). The study groups were matched for HLA-associated diabetes risk, sex, CO:COLLECTION_SUMMARY country and period of birth. This study was conducted according to the CO:COLLECTION_SUMMARY guidelines in the Declaration of Helsinki. The Ethics and Research Committee of CO:COLLECTION_SUMMARY the participating Universities and Hospitals approved the study protocol. All CO:COLLECTION_SUMMARY families provided written informed consent prior to sample collection. CO:SAMPLE_TYPE Blood (serum) CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY The bile acids were measured in serum and fecal sample as described previously TR:TREATMENT_SUMMARY (Jäntti et al., 2014; Salihović et al., 2020). #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Briefly, 20 μL of serum (prepared by adding 1:20 (m/v) ultrapure water to 50 mg SP:SAMPLEPREP_SUMMARY of feces) was filtered through a Ostro Protein Precipitation and Phospholipid SP:SAMPLEPREP_SUMMARY Removal 96-well plate (Waters Corporation, Milford, USA), using 100 μL of cold SP:SAMPLEPREP_SUMMARY methanol contemning the internal standard mixtures (LCA-d4, TCA-d4, GUDCA-d4, SP:SAMPLEPREP_SUMMARY GCA-d4, CA-d4, UDCA-d4, GCDCA-d4, CDCA-d4, DCA-d4, GLCA-d4). The eluent was SP:SAMPLEPREP_SUMMARY collected and evaporated to dryness and the residue was re-suspended in 20 μL SP:SAMPLEPREP_SUMMARY of a 40:60 MeOH: H2O v/v mixture. The analyses were performed on an ACQUITY HSS SP:SAMPLEPREP_SUMMARY T3 (2.1×100 mm, 1.8 μm) column, Waters (Milford), coupled to a triple SP:SAMPLEPREP_SUMMARY quadrupole mass spectrometer (Waters Corporation, Milford, USA) with an SP:SAMPLEPREP_SUMMARY atmospheric electrospray interface operating in negative ion mode. Separation SP:SAMPLEPREP_SUMMARY was performed using gradient elution with 0.1 % formic acid in water (v/v) (A) SP:SAMPLEPREP_SUMMARY and 0.1 % formic acid in acetonitrile:methanol (3:1, v/v) (B) at a flow rate of SP:SAMPLEPREP_SUMMARY 0.5 mL/ min. Gradient program was 0 min 15 % B, 0-1 min; 30 % B, 1- 16 min; SP:SAMPLEPREP_SUMMARY 16-18 min; 70 % B, 18–23 min 100 % B, and equilibrium time between runs was 7 SP:SAMPLEPREP_SUMMARY min. The injection volume was 5 μL and the column was kept at 35 °C. An SP:SAMPLEPREP_SUMMARY external calibration with nine calibration points (0.0025–600 ng/mL) was SP:SAMPLEPREP_SUMMARY carried out for use in quantitation. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY The analyses were performed on an ACQUITY HSS T3 (2.1×100 mm, 1.8 μm) column, CH:CHROMATOGRAPHY_SUMMARY Waters (Milford), coupled to a triple quadrupole mass spectrometer (Waters CH:CHROMATOGRAPHY_SUMMARY Corporation, Milford, USA) with an atmospheric electrospray interface operating CH:CHROMATOGRAPHY_SUMMARY in negative ion mode. Separation was performed using gradient elution with 0.1 % CH:CHROMATOGRAPHY_SUMMARY formic acid in water (v/v) (A) and 0.1 % formic acid in acetonitrile:methanol CH:CHROMATOGRAPHY_SUMMARY (3:1, v/v) (B) at a flow rate of 0.5 mL/ min. Gradient program was 0 min 15 % B, CH:CHROMATOGRAPHY_SUMMARY 0-1 min; 30 % B, 1- 16 min; 16-18 min; 70 % B, 18–23 min 100 % B, and CH:CHROMATOGRAPHY_SUMMARY equilibrium time between runs was 7 min. The injection volume was 5 μL and the CH:CHROMATOGRAPHY_SUMMARY column was kept at 35 °C. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Waters CH:COLUMN_NAME ACQUITY HSS T3 (2.1×100 mm, 1.8 μm) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex 5500 QTrap MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS The bile acids were measured in serum and fecal sample as described based on . MS:MS_COMMENTS 20 μL of serum, using the same internal standard mixtures, was filtered through MS:MS_COMMENTS a frit filter plate (96-Well Protein Precipitation Filter Plate, Sigma Aldrich), MS:MS_COMMENTS and the effluent was collected and evaporated to dryness and the residue was MS:MS_COMMENTS dissolved in 20 μL of a 40:60 MeOH: H2O v/v mixture containing the same MS:MS_COMMENTS injection standards. Analyses were performed on an ACQUITY UPLC system coupled MS:MS_COMMENTS to a triple quadrupole mass spectrometer (Waters Corporation, Milford, USA) with MS:MS_COMMENTS an atmospheric electrospray interface operating in negative ion mode. An MS:MS_COMMENTS external calibration with six calibration points (0.5–600 ng/mL), including a MS:MS_COMMENTS solvent blank, was carried out for use in quantitation. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS ng/ml MS_METABOLITE_DATA_START Samples 5000419 5000486 5000718 5001679 5002920 5004373 5000376 5000819 5001058 5000437 5000545 5002975 5000112 5000839 5001288 5003525 5000049 5000867 5001093 5001329 5003532 5000439 5000514 5002517 5004036 5005537 5002566 5004051 5004385 5000468 5000580 5001837 5002601 5004092 5004417 5000484 5000595 5002586 5004073 5005813 5600536 5001908 5004124 5004428 5000544 5000667 5002828 5004170 5005655 5000577 5000693 5001942 5002923 5004162 5005656 5001281 5001295 5001482 5003645 5000899 5001159 5001324 5001489 5000912 5001145 5001336 5003656 5000897 5001174 5001256 5001365 5001530 5002582 5004075 5004390 5005795 5000306 5000903 5001389 5001584 5003679 5600881 5000713 5004095 5002651 5004102 5004430 5600712 5000745 5002678 5004416 5600751 5000759 5004158 5005569 5005863 5600829 5002780 5004155 5005548 5005746 5600874 5002523 5002832 5004189 5005660 5005860 5600897 5000388 5001097 5001462 5003521 5003718 5000962 5001088 5001293 5001472 5005667 5005982 5600873 5000992 5001132 5001318 5001524 5002677 5004285 5005682 5005708 5600956 5002644 5004207 5002733 5002961 5004292 5005766 5001054 5001362 5003553 5003732 5001858 5002738 5002979 5004323 5005832 5000292 5001401 5001562 5601269 5002890 5004081 5004379 5601111 5001992 5004012 5004146 5005552 5005859 5000018 5000061 5000318 5000975 5001563 5000016 5000047 5001033 5001240 5001591 5000722 5002888 5004277 5005970 5000443 5000526 5002549 5002960 5004293 5000075 5001298 5000800 5004013 5004404 5005867 5000069 5000122 5000888 5001325 5003541 5000089 5000291 5000933 5001358 5003569 5000492 5000599 5002608 5004115 5004406 5000505 5001928 5002708 5004139 5004443 5000512 5000633 5001952 5002721 5004149 5005559 5000525 5000648 5001903 5002754 5004143 5005553 5000153 5000396 5000860 5001457 5000570 5000692 5002931 5004176 5005659 5000852 5001108 5000807 5000900 5001342 5001519 5000732 5002884 5005538 5000893 5001127 5001235 5001308 5001535 5001164 5001273 5001361 5000608 5000761 5004006 5004324 5005776 5000881 5001178 5001263 5001302 5000820 5000908 5001187 5001373 5001536 5000674 5002564 5004085 5004386 5005836 5600666 5000683 5002538 5004088 5004400 5005823 5600656 5000336 5000880 5001433 5001577 5003681 5005880 5600757 5002506 5002779 5004186 5005577 5005937 5600819 5000381 5000987 5001459 5003523 5002571 5002837 5004197 5005768 5005927 5600902 5002583 5002853 5004229 5004494 5005946 5600896 5002577 5002833 5004195 5005652 5005933 5600901 5002593 5002864 5005654 5005981 5600919 5002656 5002933 5004166 5005699 5005728 5001051 5001176 5001354 5001504 5002711 5004026 5004303 5005774 5005864 5002726 5001740 5002777 5002998 5004334 5005793 5600978 5001991 5004045 5004192 5005639 5005905 5601174 Factors Age:3 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:24 | sex:2 | Case:P1Ab Age:12 | sex:2 | Case:P1Ab Age:18 | sex:2 | Case:P1Ab Age:3 | sex:1 | Case:P2Ab Age:6 | sex:1 | Case:P2Ab Age:18 | sex:1 | Case:P2Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:2 | Case:P2Ab Age:6 | sex:2 | Case:P2Ab Age:12 | sex:2 | Case:P2Ab Age:18 | sex:2 | Case:P2Ab Age:24 | sex:2 | Case:P2Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:3 | sex:2 | Case:P1Ab Age:6 | sex:2 | Case:P1Ab Age:36 | sex:2 | Case:P1Ab Age:12 | sex:2 | Case:P1Ab Age:18 | sex:2 | Case:P1Ab Age:24 | sex:2 | Case:P1Ab Age:3 | sex:2 | Case:P2Ab Age:6 | sex:2 | Case:P2Ab Age:12 | sex:2 | Case:P2Ab Age:18 | sex:2 | Case:P2Ab Age:24 | sex:2 | Case:P2Ab Age:36 | sex:2 | Case:P2Ab Age:36 | sex:2 | Case:P1Ab Age:18 | sex:2 | Case:P1Ab Age:24 | sex:2 | Case:P1Ab Age:3 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P2Ab Age:6 | sex:1 | Case:P2Ab Age:36 | sex:1 | Case:P2Ab Age:12 | sex:1 | Case:P2Ab Age:18 | sex:1 | Case:P2Ab Age:24 | sex:1 | Case:P2Ab Age:6 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:6 | sex:2 | Case:P1Ab Age:12 | sex:2 | Case:P1Ab Age:18 | sex:2 | Case:P1Ab Age:24 | sex:2 | Case:P1Ab Age:6 | sex:1 | Case:P2Ab Age:12 | sex:1 | Case:P2Ab Age:18 | sex:1 | Case:P2Ab Age:36 | sex:1 | Case:P2Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P2Ab Age:12 | sex:1 | Case:P2Ab Age:18 | sex:1 | Case:P2Ab Age:24 | sex:1 | Case:P2Ab Age:12 | sex:1 | Case:P2Ab Age:3 | sex:1 | Case:P2Ab Age:18 | sex:1 | Case:P2Ab Age:24 | sex:1 | Case:P2Ab Age:36 | sex:1 | Case:P2Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P2Ab Age:12 | sex:1 | Case:P2Ab Age:18 | sex:1 | Case:P2Ab Age:36 | sex:1 | Case:P2Ab Age:3 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P2Ab Age:12 | sex:1 | Case:P2Ab Age:18 | sex:1 | Case:P2Ab Age:24 | sex:1 | Case:P2Ab Age:36 | sex:1 | Case:P2Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:2 | Case:P1Ab Age:6 | sex:2 | Case:P1Ab Age:12 | sex:2 | Case:P1Ab Age:18 | sex:2 | Case:P1Ab Age:24 | sex:2 | Case:P1Ab Age:36 | sex:2 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:18 | sex:2 | Case:P2Ab Age:24 | sex:2 | Case:P2Ab Age:36 | sex:2 | Case:P2Ab Age:3 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:24 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:2 | Case:P2Ab Age:12 | sex:2 | Case:P2Ab Age:3 | sex:2 | Case:P1Ab Age:6 | sex:2 | Case:P1Ab Age:12 | sex:2 | Case:P1Ab Age:18 | sex:2 | Case:P1Ab Age:3 | sex:1 | Case:P2Ab Age:12 | sex:1 | Case:P2Ab Age:24 | sex:1 | Case:P2Ab Age:36 | sex:1 | Case:P2Ab Age:24 | sex:2 | Case:P2Ab Age:3 | sex:2 | Case:P2Ab Age:6 | sex:2 | Case:P2Ab Age:12 | sex:2 | Case:P2Ab Age:18 | sex:2 | Case:P2Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:18 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:3 | sex:1 | Case:P1Ab Age:6 | sex:1 | Case:P1Ab Age:12 | sex:1 | Case:P1Ab Age:36 | sex:1 | Case:P1Ab Age:24 | sex:2 | Case:P1Ab Age:3 | sex:2 | Case:P1Ab Age:6 | sex:2 | Case:P1Ab Age:12 | sex:2 | Case:P1Ab Age:18 | sex:2 | Case:P1Ab Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:3 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:24 | sex:1 | Case:CTR Age:36 | sex:1 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:3 | sex:1 | Case:CTR Age:6 | sex:1 | Case:CTR Age:12 | sex:1 | Case:CTR Age:18 | sex:1 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:3 | sex:1 | Case:CTR Age:24 | sex:2 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR Age:24 | sex:2 | Case:CTR Age:3 | sex:2 | Case:CTR Age:6 | sex:2 | Case:CTR Age:12 | sex:2 | Case:CTR Age:18 | sex:2 | Case:CTR Age:36 | sex:2 | Case:CTR 12OXOLCA 9.439386266 5.49472248 8.89662696 8.152972118 8.735106241 7.506706957 3.679168608 0.867023672 0.867023672 0.867023672 5.865837669 0.867023672 6.920553878 5.020349554 6.588915388 4.968885505 9.389899878 0.867023672 8.351750903 0.867023672 7.614669194 0.867023672 6.527210973 7.825330688 6.352968143 3.38947583 9.582007308 5.302762919 8.445590587 5.925009715 7.121432544 3.690470653 8.737802932 7.737666773 8.215199659 8.258206422 0.867023672 0.867023672 4.927503881 6.287697183 5.106504735 0.867023672 7.074155508 4.071160289 0.867023672 0.867023672 5.348474624 6.300195942 5.070846647 7.36748867 0.867023672 6.359438852 5.61414654 0.867023672 5.359783232 0.867023672 5.232818414 7.070710028 7.15604518 0.867023672 4.823827819 7.840816933 8.681017337 5.501100557 0.867023672 0.867023672 6.252222899 2.496171214 6.601438087 10.57302215 0.867023672 7.23928771 0.867023672 7.954320329 10.13008185 6.586642669 3.793293538 9.036324585 6.762077973 0.867023672 6.946917006 7.687902726 0.867023672 9.158516848 7.338262077 2.556016067 6.789143487 7.798368687 0.867023672 3.805076641 6.540040627 0.867023672 9.041289482 6.190202986 0.867023672 0.867023672 6.718177207 0.867023672 6.038313511 0.867023672 6.767356158 7.683507403 0.867023672 5.251463088 4.42319709 3.961308798 5.379180393 4.760644154 5.469498198 5.545867664 4.623379711 8.256995606 0.867023672 0.867023672 0.867023672 7.020217526 6.330459159 6.483826358 8.1294068 4.102356849 5.557289787 5.267616611 8.64909171 0.867023672 5.339526642 0.867023672 0.867023672 6.819772075 0.867023672 0.867023672 10.24859512 6.310668218 0.867023672 8.715848594 7.578539666 8.615392004 7.519111437 1.885745234 6.554817488 8.865754615 0.867023672 0.867023672 6.200512448 5.442816644 5.107757435 7.642304727 6.979430789 4.5571006 10.73620216 10.44058026 6.386825882 8.373887097 6.51150596 0.867023672 0.867023672 7.87340206 4.212475079 0.867023672 6.724934914 6.336875783 0.867023672 0.867023672 8.222063672 5.46517024 6.887830306 0.867023672 7.25429402 6.473861629 7.991194256 4.897057661 4.621803766 9.850531962 5.470965551 10.52508045 11.86596531 0.867023672 7.90880181 7.189330509 5.01797756 4.614954994 4.238663283 7.396301676 4.35043003 0.867023672 1.867023672 9.087771564 0.867023672 5.46691316 0.867023672 5.912871202 5.034583974 0.867023672 5.20188198 0.867023672 7.902493755 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7.904577747 7.128532342 6.744294069 3.947339507 0.867023672 7.755658021 6.959053525 9.628067208 4.83717493 4.966632021 5.283880027 0.867023672 0.867023672 7.744984715 6.881463569 10.17473772 6.043352776 0.867023672 0.867023672 8.861341013 8.190873655 9.209312542 6.00784476 8.88155492 5.936894438 0.867023672 6.091800072 9.894893547 3.970743979 0.867023672 6.138211908 5.159114528 0.867023672 5.263499559 0.867023672 7.017318409 0.867023672 10.78767008 9.964647794 0.867023672 6.054902886 5.025715941 8.097006594 5.581422251 5.876750897 0.867023672 5.325643054 8.590869801 7.317777599 9.118281788 8.647290316 4.875118295 8.516072784 4.357259292 6.649782278 7OXODCA 3.617826548 1.083929273 2.186053955 2.378550843 1.826718226 0.494610376 -9.018422968 -9.018422968 0.366590043 2.098056828 -0.367908368 -9.018422968 -0.733650061 -1.180988478 -9.018422968 -0.124515239 0.611119181 -9.018422968 3.41022587 -9.018422968 -9.018422968 6.464894906 1.425761639 1.99466374 -8.018422968 1.624419035 3.848107526 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1.95758566 0.75116151 0.832888438 0.749436086 1.868025271 0.700593576 0.749829578 0.915900782 -0.394777289 0.951771698 1.127768663 0.831777532 0.833522865 0.672118632 0.724258524 -0.394777289 0.76838711 0.756441178 0.809768258 0.832759562 0.615780402 0.753747568 0.793480285 0.983763915 0.983727652 0.678365481 1.27546984 0.688240918 4.901410229 0.890149689 -0.394777289 0.703080869 1.739920621 1.656630516 0.755804118 0.700038521 0.876546762 1.02073356 0.692241044 0.701360097 3.458786739 5.846034822 3.755411858 1.27240958 1.255352106 -0.394777289 0.828230288 1.761611438 0.701757462 0.774008604 2.273836237 1.844232123 0.748805959 0.738527899 0.905773704 -0.394777289 3.759035947 -0.394777289 0.823927925 0.87877205 0.818329404 1.605682844 3.87963106 0.879384751 0.665554351 0.775898239 0.838900159 2.730127063 0.804306911 1.111868063 0.855861 3.732822962 5.226610489 0.806078149 0.772091017 0.89090329 0.786797242 0.954229399 0.675530619 3.707890484 0.886598293 1.68279562 1.850626869 0.77083016 0.685944019 1.400316873 1.440738365 3.929418247 4.35141974 0.76633967 0.963492092 1.539548783 0.747498851 0.70415701 0.749851951 0.805960345 3.848335171 0.638507976 3.994449054 0.637685009 0.670944262 1.763055924 3.571464365 0.759802149 0.81173764 0.774377258 0.918493566 0.781756196 1.803844313 2.230188066 0.719736288 0.679520379 3.73013008 0.848033789 0.735099968 -0.394777289 1.180636011 3.909515502 0.692129111 0.889635716 -0.394777289 0.870648253 0.738806932 0.945357584 0.67916341 1.609941333 0.663287205 0.981966731 0.663034816 0.928344576 0.804594312 0.710818468 0.992563666 0.812071318 0.853727802 0.712458727 0.718987597 1.014347735 2.389973558 2.234370618 5.101329399 1.081431367 0.817663836 0.764877358 1.833682394 -0.394777289 2.008131625 0.833744437 0.872679257 3.835031188 -0.394777289 2.16906134 3.638240757 1.743784361 0.722340299 0.675495713 0.754463423 0.716579605 1.014698039 4.850082869 0.760555661 0.696535192 0.82453936 1.56659018 1.047894203 0.96477291 2.579168741 0.823230909 1.607398475 4.026051674 0.85632016 0.752818597 0.828945074 1.265593317 0.931270617 2.05841447 0.832074158 0.73059674 0.879379367 3.666780882 2.473806434 3.018839361 0.737924936 0.816351872 0.864659017 1.659128643 5.576732416 -0.394777289 0.723708702 0.689282135 0.95014759 0.817592462 0.794113802 0.76880229 1.791064871 0.688623038 0.751367413 0.90216159 2.757174515 2.411084922 2.848674052 0.848029232 1.671806041 0.750262927 0.815330852 0.693815837 2.200853728 1.050374801 4.810719133 0.68088558 0.792446432 0.815246544 2.744849614 2.623077083 HCA 5.857962577 4.709456279 3.127133245 2.515458436 2.81093518 3.487332278 1.953756591 2.093848944 2.983060476 5.089405734 1.493432889 3.626789134 3.841635973 4.427438749 1.992564573 2.525262896 3.788828853 3.483976484 3.626056865 3.980702892 2.615892736 8.720080946 2.852600325 2.932206245 4.529282019 3.318206855 3.259524885 2.154598716 4.864096299 8.790860488 6.444226436 0.449447178 3.141988139 2.416388011 3.948394761 5.585146397 3.452077033 4.007157738 5.202856085 3.298844908 2.511850783 2.392899293 2.888509553 2.95259915 6.045061631 4.414739461 2.947576924 2.365744776 2.946741796 6.20661376 3.499993555 2.523494728 2.748645433 3.110634734 2.752455611 2.751877093 2.022930158 2.769845151 3.480435408 3.647195707 3.393153574 1.884113431 3.168777137 2.56259185 2.688137793 2.881324 2.626411871 0.449447178 2.788011443 7.836275403 2.428758739 3.092083368 5.647078162 2.853468769 3.02316391 3.068522269 4.096790843 7.032098111 3.011001398 2.310094531 2.900621611 3.868458299 0.449447178 1.918128007 3.699061558 2.570795704 1.848616087 2.23397355 3.887034595 5.449582287 1.925834732 1.831652697 4.425130263 6.24073833 2.5583721 3.462961103 3.413040797 4.379937319 2.84102712 2.716390523 1.550130151 2.17448794 1.890007174 4.646623175 3.540954455 3.161440614 1.770632526 1.848271941 2.038109539 4.946377579 2.673571249 1.834268394 2.490004234 7.01088674 0.449447178 3.140778384 3.792727509 3.203126724 2.457065374 1.449447178 7.607160158 6.03767354 4.276091123 2.478990669 3.478223031 3.696380187 3.928397254 2.242953685 1.574866404 5.184133565 2.963254408 5.980480794 3.832426888 1.90465612 1.832525822 5.227614839 3.931222282 3.104839533 2.660651522 4.468951505 6.976634794 4.983229505 3.401578319 2.227872978 4.869409519 3.898460438 2.325690777 1.843654867 7.696643489 6.415976646 2.866069952 3.239716536 2.0594819 3.512387367 3.590618156 3.863926694 4.156690709 4.61900913 3.730586503 2.217386831 2.675867738 1.884438555 6.797516915 5.741440759 3.406032039 1.570844845 4.070952356 3.552325146 2.983673065 2.559018813 0.449447178 7.689542989 3.361677034 2.736311162 4.52184417 1.758356176 5.57236024 1.814243597 3.330890699 1.971996166 2.673080052 2.341628504 7.976426669 3.417739148 0.449447178 1.733566625 1.576463624 6.599191207 4.741929399 2.47043977 2.429222621 1.875966305 8.391787837 5.419911875 4.217623569 1.47157759 3.053359308 7.097619791 3.947361193 3.536794302 2.823178064 3.161004148 6.235385666 4.470834469 3.789234546 4.930547152 2.923808397 4.77840912 5.816050911 6.229385533 2.305798137 1.803371674 3.034758508 2.452093135 6.652019257 0.449447178 4.202923473 3.772353581 7.915626525 2.050012178 3.491498559 2.239318467 2.077234481 7.131316141 3.303130625 6.974162276 2.859975184 2.190965493 2.301851073 5.663192778 6.583608852 3.26737707 5.346222647 1.601700264 6.512768186 3.321017056 1.516053265 2.476385029 6.456688288 3.239499003 5.655162073 4.088810533 3.889378462 2.310629096 2.536304502 0.449447178 2.937753464 1.586384547 1.519601121 0.449447178 2.486281237 3.104804543 1.727912057 3.147373051 5.98445855 5.182844088 3.600713301 3.409779418 3.659171629 2.84686312 6.805594335 5.158052506 3.573650304 2.325667432 3.72528602 2.750292472 2.623350638 5.653507349 2.461700132 2.564931495 2.429868625 2.604146033 1.969010415 5.925588182 3.662186861 4.287683049 2.213462055 4.211956029 2.17461633 1.991492305 7.195245273 3.260032874 3.719408663 6.092091634 5.632483516 3.206936121 3.067975363 2.382392614 3.164752378 7.336559211 5.341158879 3.371157184 2.349019571 3.891857076 2.646711764 7.319304338 3.826149756 3.566804515 2.20056279 2.928714206 2.117301389 4.925579104 3.903247046 2.791122916 0.449447178 3.760218636 6.816022148 3.836388483 2.60132676 2.020694446 2.54283368 5.091596214 4.388572297 3.231614111 3.547387093 7.347261042 8.912484628 2.169215253 2.223712321 3.06051183 7.386383723 4.599003166 4.506510126 5.689468415 2.238674096 2.832106464 2.49623284 2.615326648 5.270075016 3.612569399 3.932669808 0.449447178 2.434155768 HDCA 2.378823467 2.492419574 3.101098724 6.80818821 3.291653741 7.88462675 2.018767915 0.277768172 1.998547032 2.873832233 1.296428837 0.277768172 4.8434324 2.064856128 2.438406265 5.180794636 9.40558507 0.277768172 8.763078661 3.724091209 5.018389119 2.367441678 2.165696615 3.797704761 3.526482648 2.674947041 9.48963896 5.843097119 8.411288716 1.884416775 2.90227134 0.277768172 8.058479973 6.472214485 6.87447685 2.462930403 3.884539512 8.032599698 2.705588649 0.277768172 3.097345057 0.277768172 6.521583553 2.191540881 5.032192133 3.814942876 2.16053213 6.399634751 0.277768172 4.602811848 1.842876786 1.673905728 1.755172487 4.091044378 1.450093977 0.277768172 5.065858717 6.422718279 5.921530558 2.183455999 8.783429988 3.15721549 7.471977209 0.277768172 1.591031162 4.170100983 0.277768172 0.277768172 2.10310827 4.886287662 2.959820085 6.064699368 1.829551256 2.112147395 1.841118681 6.2695744 0.277768172 3.058287592 6.055150007 4.874683324 5.09353374 7.763157786 0.277768172 4.842127245 1.809358714 2.392453756 7.386532047 6.206712188 0.277768172 1.277768172 5.462312841 1.647945799 0.277768172 2.682565069 2.177166919 0.277768172 6.234793686 0.277768172 4.852307793 1.48988089 6.060841313 6.463894388 0.277768172 1.559723829 1.653995276 1.484153779 2.610471366 4.35126679 0.277768172 4.373633724 2.882547249 7.501937298 0.277768172 1.498065952 0.277768172 3.99089838 0.277768172 6.078105721 6.537766874 2.337098817 0.277768172 1.365065867 7.84587297 5.013707243 0.277768172 1.398726648 7.575993567 2.005295724 5.033280432 0.277768172 5.275708878 1.434124718 0.277768172 3.178265754 6.038145759 2.700834043 6.611412378 2.638747512 6.376267129 2.444930846 0.277768172 2.735428419 1.529493902 6.281119144 3.131550127 6.886697192 5.976978524 3.841326843 4.83616511 4.540416728 7.190075492 8.200230538 6.796015639 2.053232475 0.277768172 3.47446201 2.700876025 0.277768172 0.277768172 1.914028453 5.622406574 2.881475759 8.834399296 4.546952356 6.953365039 1.471327414 7.611027837 5.466297571 7.81154862 1.822546333 1.529131671 4.022039095 1.736302176 3.248865964 10.63125752 2.0669927 0.277768172 6.069506467 1.579521443 3.444428027 8.629474666 6.417306292 2.334791365 4.152060321 0.277768172 2.167163291 3.970020855 0.277768172 2.400525219 5.411337575 2.038912775 2.797634648 1.649700545 2.043379887 5.68298585 1.376351891 4.644528344 2.555898892 6.935069979 4.349093068 7.227042281 6.193270368 3.549965806 2.270597205 8.020813543 3.006542142 2.570808845 11.69265617 0.277768172 5.098456484 6.104651475 4.938621798 6.847782179 7.365987407 4.619514362 3.285293184 4.629493397 7.801799294 4.377664068 0.277768172 7.317199678 6.455280942 7.281544997 2.844849695 0.277768172 0.277768172 6.238418054 1.716074708 1.925453403 0.277768172 6.699477761 2.342841583 0.277768172 2.634456477 3.539160334 0.277768172 2.933746385 2.24432945 6.644695032 8.303052234 1.949756113 0.277768172 0.277768172 5.276794214 6.590058304 0.277768172 7.676130321 0.277768172 2.505154385 0.277768172 6.132141867 2.176754996 4.331147218 6.464914814 3.578309951 4.67121104 8.554186672 8.323697185 2.849419647 6.427463577 3.129512558 3.420049184 5.822825415 4.73057594 6.146685602 7.384515951 1.398084093 0.277768172 2.74800468 3.728146564 4.654964988 2.85794019 0.277768172 0.277768172 0.277768172 3.220558204 6.306999704 2.277273323 3.063689004 4.789867599 4.947518076 2.865621391 4.195411768 2.962208148 4.340090374 5.524011999 0.277768172 1.760295888 8.306376746 0.277768172 0.277768172 5.072171917 6.838381525 8.460062894 3.037197517 2.391405733 0.277768172 8.72039962 7.397250633 8.278736845 1.74409702 2.069595567 2.063646121 2.467965645 3.899735997 8.509646779 2.978478049 5.133211159 1.29123969 5.080271352 4.695022107 2.240985269 3.706324759 3.218546463 3.966879534 5.06343771 4.35407487 5.132664374 1.98609133 5.934577311 3.027156818 8.543450612 1.671967508 2.014791627 2.539431748 2.653497206 4.935624933 2.286981196 7.889723433 0.277768172 8.015900676 1.501614263 5.993324002 TaMCA 9.988261054 6.55395439 4.098208068 4.055376017 3.832897104 3.341810697 4.760905655 6.465589098 4.077010769 7.770173838 2.531626215 7.384801544 6.54210668 4.287078913 4.569182007 4.225101316 4.327119159 8.166312966 5.104402552 4.191780728 5.473102532 9.560609362 7.368479733 4.147837148 5.605432268 4.576991496 4.036120535 4.941641686 7.168120391 9.764450971 8.15713549 3.664013678 4.616621461 4.240202618 4.371927434 7.952001845 6.129173929 5.643663095 5.599618045 5.950454953 5.14465338 5.692755731 6.224127405 6.61661069 8.481037475 6.478232078 4.949831675 4.367317583 5.781913732 9.392134003 6.966589437 6.840478273 4.932754112 4.351040848 6.693250877 6.293253428 5.437699052 6.603463028 5.714147407 8.398522695 7.598686587 6.143527504 6.628669255 5.852079223 6.346251882 4.371596491 6.845739907 1.208488811 4.58419348 6.948388975 6.556974277 5.313098359 8.42951989 8.103654828 6.779964675 6.029120863 3.888577871 9.482571045 5.858030708 6.039861777 5.439725204 6.864358314 1.208488811 3.279065453 6.780506365 4.71606241 3.091377446 4.329165754 9.885066687 8.50201683 3.641390034 5.140482592 8.931624027 9.385621929 3.490857183 3.604291167 5.819301736 8.654304206 6.284845382 4.582041294 5.396736643 5.528408691 10.65661813 8.838076764 7.606578656 7.691636618 5.726658189 7.742097997 5.027808697 7.263640699 4.578365365 4.635604203 4.963494479 10.67282151 1.208488811 8.141958857 7.617626476 6.493753161 5.958318719 2.767719518 9.440378483 6.626483177 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4.823047622 4.327383009 8.595232913 7.920297636 4.665987394 2.65931076 4.862381273 3.508655541 9.653468932 7.406456273 7.912971132 7.79125769 8.472225957 3.521823528 7.673932186 6.572557322 4.351731309 7.32741361 5.920065958 9.209543144 3.623734411 6.4414486 5.295032461 7.63741648 7.631844617 6.44617348 8.809627657 2.511325799 8.913454209 5.017329968 4.22443688 3.252737697 8.601200048 6.219442476 9.606313264 8.404423038 4.791721854 5.441420916 4.816913427 2.208488811 4.929033227 1.208488811 3.288189209 1.208488811 3.525875855 6.419039096 5.171643581 6.024967195 8.863703552 6.169636665 5.819272073 5.812219443 5.40302733 5.758461212 8.465576364 7.429405596 6.3909796 6.180815898 5.478396454 4.761857797 6.746125051 9.419357585 6.483163806 5.541120556 5.127883434 4.372808111 4.924340555 9.62691787 7.684677548 4.496519332 4.055491531 6.65016172 5.183596754 6.457322166 9.049809935 4.747785428 6.773413241 10.91248394 7.600591692 5.571897057 7.050527626 5.517711697 6.472927946 8.780471674 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10.69784833 11.38739345 12.23339668 10.23611385 9.719866136 10.24860376 10.52231253 9.649745548 7.651051514 10.73004657 11.02897019 11.28398086 10.12048208 10.95851168 10.57494799 11.61340937 8.047358462 9.41068229 9.620976682 11.22795127 0.714909851 10.96463372 -0.285090149 10.99712738 9.782409031 11.674721 10.77801066 9.911239494 10.06457227 9.823187508 11.96970529 10.63455681 10.86895688 11.21674107 11.70676167 1.764515359 9.770923891 9.967818668 11.3888982 9.200085596 8.442046312 10.55362577 8.01424158 9.898126431 10.39805185 9.764274178 11.30800478 8.78126042 7.924325097 10.51490922 11.15746739 10.29965294 10.4692909 10.2540548 10.12863102 11.43818232 10.36508972 10.99767018 10.77155542 7.184387334 10.84050006 10.3004219 10.16285814 11.12024786 10.45408199 10.52681207 10.56965207 0.98005519 10.32564979 11.27091775 10.67666355 9.965827436 6.100036316 11.0127505 9.772432576 8.828964162 8.583473735 10.02148234 9.265907326 10.17989985 9.876858192 6.336075388 12.32759202 9.427807923 10.34655389 10.33689692 9.626592411 8.874954375 9.716377047 11.06277633 9.173874392 9.953638257 10.23680477 17.44321661 11.86096352 11.51690513 9.85823916 9.257752587 9.733247477 9.722051962 10.38866101 12.45180089 11.31457298 8.625088815 9.230960646 10.48337069 11.30287967 11.45502891 10.65239554 10.5904178 8.670032368 10.55846023 17.08414382 10.74248761 9.855780268 11.89835664 11.1798209 10.99906228 7.830180469 10.74473613 10.43226014 9.32479004 8.954964367 8.03448712 13.00268532 9.446543844 16.99743714 10.48364526 8.084675067 10.59714883 11.3876677 9.789446607 9.3531817 -0.285090149 9.769462508 12.17835648 9.786054218 7.007359863 9.027525903 10.36914058 12.36074459 11.02174262 8.803808212 9.868686615 10.60803891 11.37214641 12.07583307 11.54530247 7.339171145 10.11258397 9.803223009 11.63920643 10.86457145 11.09674188 10.15294418 10.96986852 11.73845222 9.693512351 10.33563076 11.40546314 9.463354943 10.49209465 11.48602127 9.115214686 7.943602928 10.54885171 9.223330401 11.22950204 9.703709499 9.636084071 -0.285090149 11.20653032 7.188217867 7.636004255 11.11261092 9.653930491 12.0977546 9.654180444 11.67363969 6.699737752 11.62031801 9.94006635 10.03461242 10.69262907 10.59256407 10.955336 5.151596314 11.58311711 10.56994051 10.48865671 7.267402482 12.58475186 10.38388934 11.00667748 11.04891257 16.77871833 11.22562893 10.53323532 1.211439293 8.81480409 1.204746873 6.627203061 2.119166054 8.262531837 11.15885448 10.78649884 10.27748584 12.40445734 8.85107311 10.84329071 9.70096546 10.51761335 10.33181906 11.94270935 9.885140396 11.36150898 11.30270176 10.59369108 10.16031486 8.654681169 13.45682127 9.682863394 8.612435514 9.295226465 10.07432336 10.13441775 12.37634035 10.33784424 10.557241 8.499420277 11.58990757 11.11918925 10.40810412 11.08783475 10.95328842 9.731511016 13.96052492 12.96018463 11.19286185 12.23779426 9.583138159 -0.285090149 11.70966856 11.73726002 10.52683608 9.218152122 9.360813573 11.0932754 11.64838232 9.820957691 10.76698012 10.11202892 10.04072409 9.586623884 9.705335891 10.56164132 10.94809429 7.462178803 10.42591585 10.75482717 10.34588972 7.360454148 7.363261552 10.07749297 11.78106264 9.774012819 9.820024909 7.901114095 11.32657804 13.24120372 10.52793186 11.42807635 10.84210894 11.10284304 -0.285090149 13.12486077 11.85855981 16.76794928 11.48695181 11.06278149 10.30564408 11.58100654 10.93647228 10.96308076 5.847352033 11.19014648 TCA 9.441636544 5.551967503 4.359058933 6.49574032 4.309689608 3.951200428 5.844677715 7.38372813 5.877207021 7.46928511 1.110412145 6.777195515 5.538922885 5.444067622 6.895327433 5.413131668 4.97014796 15.41787479 6.736033206 4.988357491 11.82362008 7.708254259 6.719061452 5.818133855 7.526105611 5.679540561 5.820299229 6.8529707 7.503657299 8.541692269 7.319689136 3.50084501 5.892718072 4.596010427 5.365432453 6.511203516 5.75375237 6.703322721 5.859080964 5.976210058 5.880112993 5.587519783 6.272527357 6.817387968 6.815263401 6.017311998 6.621629653 6.01291987 7.553380414 7.928870796 6.89144113 6.374559348 6.511335868 5.593095519 6.419380894 4.791723394 5.436137841 6.833052413 6.393863469 7.860651642 7.465887613 7.694245407 7.63310718 4.881154781 4.395822193 6.65695725 7.088653549 2.131299857 6.771888039 1.110412145 6.812643516 6.013685586 7.732918829 8.36773806 6.648566046 6.370017439 4.331294423 7.754220846 6.342778612 7.592305031 6.365817213 7.312285072 2.110412145 4.620773001 6.191751573 6.467326199 4.098839019 3.546071661 8.684827147 6.958006383 5.939787621 6.517859282 6.689457341 8.225450475 4.155374328 3.645990826 5.911867007 9.668937504 7.469726509 7.744528303 7.935872288 6.991246892 9.561619204 8.045737363 7.789875695 8.793946524 4.024375021 7.817300645 7.46790573 6.364749936 5.901901252 5.253729953 5.737554315 8.713129613 1.110412145 7.658992947 7.824156276 6.63683806 6.858702045 3.396691796 7.535271977 5.521128331 4.731712234 3.639182381 8.167313716 4.765997096 5.130412305 7.499512421 1.110412145 11.33537571 4.971556932 8.379195845 7.205983964 5.839601622 4.183623155 5.545560052 6.073424597 5.042537116 5.805301601 6.830431005 15.41085345 9.384016656 7.401318345 4.473252533 5.2405742 6.209308574 5.156926908 5.904311947 9.041751769 7.761850643 5.522950371 4.461181738 7.20457731 9.707374282 8.141655301 6.356228581 6.488936612 8.771966126 9.571121008 13.40989299 7.716790096 7.610130917 7.102379534 7.563847882 7.087982338 5.429778576 7.559158775 6.646742983 5.228482529 5.612531155 5.194254963 9.50588399 4.469488813 11.95981116 4.854415818 4.317454697 8.866726792 7.790509587 4.170308613 5.511496507 1.110412145 4.978572415 8.956255956 6.650784661 3.385592351 4.393394863 5.714110906 8.476512593 5.996147299 3.989584358 5.871416307 6.556649147 8.490364289 8.900929349 8.214233426 3.367684916 6.231890188 5.601370373 7.45793601 6.428119745 6.980746817 6.884321963 7.205630901 8.199970322 5.043026796 6.142475267 7.085055056 4.055314564 7.566611085 7.971260829 5.018898299 3.325896081 6.528781208 4.351177317 9.000321953 7.43177043 7.354858664 1.110412145 6.93730412 3.845292645 5.029353529 7.342919746 5.110404581 7.720247338 6.259839704 8.639705121 4.63487397 8.30244094 6.085106864 6.530242045 6.242274185 6.480542893 7.040532518 2.903267083 8.167494615 4.9854572 6.230367257 2.731189613 7.877303521 4.990849381 8.888880709 8.726362149 11.39166911 6.919057221 5.90236057 2.292091918 4.214732034 1.110412145 3.45773988 2.347087615 4.074203242 7.267300959 6.563908501 6.720027118 8.021341405 5.631981181 6.175538465 6.610351669 6.171503228 5.966748757 8.733612526 7.169365231 6.890753871 7.2839581 6.578161761 5.286759701 5.614020181 10.19667142 6.523449331 5.340334045 4.933114254 5.921803847 6.716069713 8.758895388 7.510710844 5.019945742 4.664062609 7.067189059 6.043860818 7.331982182 7.277472325 6.136928269 6.196074149 10.94301187 9.613445796 6.360405732 8.781437554 5.408110346 1.110412145 8.022084995 8.64940074 6.677855125 4.797107358 3.777312912 5.733745347 8.706797513 7.041637506 6.002655517 6.623068656 6.007414419 5.829690481 7.53679433 7.174180386 6.607428623 3.65743467 5.420151617 6.684778673 7.597961546 5.037221061 5.193037429 6.825129814 10.90585315 7.7147163 7.054996641 4.588878927 5.971834213 9.051444793 7.756265537 9.605870059 8.435963875 8.009747801 1.110412145 10.09700515 8.470752089 12.97406001 7.476728947 7.499711521 6.62065917 7.725606709 8.335390106 7.51443276 2.768582485 7.661611168 TCDCA 11.32261894 7.815388145 6.034343092 8.153086142 6.060698418 5.729494122 7.822567279 9.500443817 8.055892099 10.00635574 3.650232982 0.620128633 8.067963995 8.087558848 8.848128503 7.261615106 6.41306273 0.620128633 8.61890309 7.310933817 0.620128633 11.15469045 8.224565084 7.354439405 9.055644928 7.166473184 7.510687296 0.620128633 8.822286375 10.94280308 9.799305872 4.551958775 7.910103721 6.88415939 7.018137179 8.928554853 8.236501024 0.620128633 8.149317532 7.546664358 0.620128633 0.620128633 8.344590764 9.413653695 9.562899605 9.168553934 8.534477801 7.71006197 9.023645375 10.38276898 9.495870428 8.360337693 9.289792348 8.219553191 7.880437636 7.438989987 7.682961595 8.517718338 8.760934572 11.20083702 9.466344967 9.309068629 9.666547581 7.921267346 6.886251396 0.620128633 0.620128633 0.620128633 8.625573014 0.620128633 8.287646685 7.779410263 11.03794394 10.85539088 8.563630775 8.27543327 7.081820524 11.03013293 8.380181247 9.151675851 8.092724233 9.747804561 1.867175964 7.087456144 8.878214466 8.424585125 5.980969965 5.408613071 10.57898191 8.593873101 6.693094291 7.951499392 9.472147812 10.97850306 6.421810045 5.870026967 7.596526546 11.45137835 9.265628913 8.953949009 8.909403007 8.826091645 11.08532191 9.963517033 9.171484168 8.99793511 5.336224349 9.382645562 8.514731399 9.683303864 8.48067314 7.502225273 8.243953032 10.63722758 0.620128633 10.13237389 9.861890345 8.081092859 8.086935036 4.943442063 10.78876957 8.74111263 7.298237795 5.753503427 10.68610428 7.056826747 0.620128633 10.13051381 0.620128633 12.92025516 6.614665071 10.08331183 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9.541286362 3.603225126 10.17125969 5.69396648 5.756753941 0.620128633 6.748923582 10.76150885 8.814002238 10.88736309 6.568350965 9.742730341 7.265635629 9.100408348 9.232028775 7.506122416 9.981574117 3.829064914 10.70212595 7.857377861 7.996579967 0.620128633 11.32414148 7.928743771 11.49137307 0.620128633 0.620128633 8.164248289 7.631865027 0.620128633 6.023536499 0.620128633 5.290570436 0.620128633 6.063102218 8.819102873 0.620128633 8.435252955 11.93820575 8.458430339 8.214977526 8.50211292 8.284842176 7.813267354 11.45912673 8.658231314 8.587235679 8.738042822 7.972148455 6.986638798 7.611555465 0.620128633 7.749792439 6.174706563 6.910918684 7.535152357 8.262382962 10.50514764 9.643273686 0.620128633 6.388560592 9.110757388 7.778943957 8.907609897 11.37932967 8.113495732 8.098845014 13.2603567 11.71687449 8.643051928 10.39690966 7.353916663 0.620128633 10.41109806 10.72796874 7.755813519 6.7909037 5.66814387 7.998240476 0.620128633 9.546429335 8.377126255 8.055885482 7.578570475 7.404487739 10.62290973 9.720956155 8.528443323 5.530639968 7.155908083 9.898953323 10.33744203 6.446981519 6.380163667 0.620128633 12.53599616 9.282663489 9.220622178 0.620128633 9.339428113 11.05291409 9.313374008 10.92937312 9.46524301 10.71546337 0.620128633 12.28834389 10.89026196 0.620128633 9.245914537 9.027756506 7.989960002 10.32137602 10.11552962 8.853066567 4.166536138 9.152790885 TDCA 0.729953987 0.729953987 0.729953987 6.163604957 0.729953987 3.379048123 4.770517008 5.724926584 0.729953987 0.729953987 0.729953987 3.563477559 0.729953987 2.280474079 6.594386935 5.066477661 3.488108699 0.729953987 3.87624546 5.201850343 11.68104059 0.729953987 0.729953987 0.729953987 0.729953987 0.729953987 0.729953987 0.729953987 5.95208935 0.729953987 0.729953987 2.777901011 3.434560841 3.161382655 4.244319027 0.729953987 0.729953987 0.729953987 0.729953987 5.412724675 5.818785717 3.903406083 0.729953987 4.16900286 0.729953987 0.729953987 0.729953987 4.967063697 0.729953987 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4.523073205 2.470160553 4.869663428 2.470160553 7.367094324 7.098733713 4.524318463 5.084650963 3.95758363 4.557112289 6.442416638 4.277279364 5.720731766 5.342323679 6.76315615 7.302312909 4.603985587 4.887327394 5.312086502 7.326930242 2.470160553 6.298390945 6.719684369 2.470160553 4.474831734 7.157016159 4.571987539 7.58010694 5.389151931 7.687084621 2.470160553 6.656324597 LCA -2.976252632 -2.976252632 -2.976252632 0.803808037 -2.976252632 4.327074134 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -0.798947562 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -0.984285209 -2.976252632 -2.976252632 -2.976252632 2.161069993 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 1.97142612 -0.058907829 -2.976252632 3.524993132 -2.976252632 3.903429454 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -0.345440132 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 -2.976252632 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448.3 74.002 GDCA 12.65 448.3 74.001 GHCA 7.78 464.3 74 GHDCA 8.84 448.3 74.003 GLCA 15.7 432.3 74 GUDCA 8.46 448.3 74 HCA 10.65 407.3 389.2 HDCA 11.93 391.3 391.303 LCA 18.14 375.3 375.3 TaMCA 4.35 514.3 106.902 TCA 6.77 514.3 124 TCDCA 9.1 498.3 124 TDCA 9.72 498.3 124.001 TDHCA 3.37 508.3 80 THCA 5.53 514.3 106.901 THDCA 6.36 498.3 80.001 TLCA 12.36 482.3 124 TUDCA 6.14 498.3 106.9 TwMCA 4.35 514.3 106.9 UDCA 11.39 391.3 391.3 wMCA 8.68 407.3 387.2 METABOLITES_END #END