#METABOLOMICS WORKBENCH micaelaroy_20211227_102320 DATATRACK_ID:3007 STUDY_ID:ST002031 ANALYSIS_ID:AN003301 PROJECT_ID:PR001288 VERSION 1 CREATED_ON January 3, 2022, 7:48 am #PROJECT PR:PROJECT_TITLE Irradiation causes alterations of polyamine, purine and sulfur metabolism in red PR:PROJECT_TITLE blood cells and multiple organs PR:PROJECT_SUMMARY Investigating the metabolic effects of radiation is critical to understand the PR:PROJECT_SUMMARY impact of radiotherapy (e.g., for bone marrow irradiation prior to hematopoietic PR:PROJECT_SUMMARY stem cell transplantation in the clinic or in laboratory studies), space travel, PR:PROJECT_SUMMARY and exposure to environmental radiation. In patients undergoing hemopoietic stem PR:PROJECT_SUMMARY cell transplantation, iron overload is a common risk factor for poor outcomes. PR:PROJECT_SUMMARY Previous studies assert that both irradiation and iron independently modulate PR:PROJECT_SUMMARY tryptophan and indole metabolism of the microbiome, which may in turn impact PR:PROJECT_SUMMARY host immune response. However, no studies have interrogated the multi-organ PR:PROJECT_SUMMARY effects of these treatments concurrently. Herein, we use a model that PR:PROJECT_SUMMARY recapitulate transfusional iron overload, a condition often observed in PR:PROJECT_SUMMARY chronically transfused patients with thalassemia, sickle cell disease, or PR:PROJECT_SUMMARY myelodysplastic syndrome. We applied an omics approach to investigate the impact PR:PROJECT_SUMMARY of both iron load and irradiation on the host metabolome. Our results revealed PR:PROJECT_SUMMARY dose-dependent effects of irradiation in red blood cells (RBC), plasma, spleen, PR:PROJECT_SUMMARY and liver energy and redox metabolism. Increases in polyamines and purine PR:PROJECT_SUMMARY salvage metabolites were observed in organs with high oxygen consumption PR:PROJECT_SUMMARY including the heart, kidney, and brain. Irradiation also impacted the metabolism PR:PROJECT_SUMMARY of the duodenum, colon, and stool, suggesting a potential effect on the PR:PROJECT_SUMMARY microbiome. Iron infusion affected the respose to radiation in the organs and PR:PROJECT_SUMMARY blood, especially in RBC polyamine metabolism and spleen antioxidant metabolism, PR:PROJECT_SUMMARY and affected glucose, sulfur (especially methionine and glutathione systems) and PR:PROJECT_SUMMARY tryptophan metabolism in the liver, stool, and brain. Together, the results PR:PROJECT_SUMMARY suggest that radiation impacts metabolism on a multi-organ level with a PR:PROJECT_SUMMARY significant interaction of host iron status. PR:INSTITUTE University of Colorado Anschutz Medical Campus PR:LAST_NAME Roy PR:FIRST_NAME Micaela PR:ADDRESS 13001 E 17th Pl, Aurora PR:EMAIL micaela.roy@cuanschutz.edu PR:PHONE 9259977554 #STUDY ST:STUDY_TITLE Irradiation causes alterations of polyamine, purine and sulfur metabolism in red ST:STUDY_TITLE blood cells and multiple organs (Whole blood) ST:STUDY_SUMMARY Investigating the metabolic effects of radiation is critical to understand the ST:STUDY_SUMMARY impact of radiotherapy (e.g., for bone marrow irradiation prior to hematopoietic ST:STUDY_SUMMARY stem cell transplantation in the clinic or in laboratory studies), space travel, ST:STUDY_SUMMARY and exposure to environmental radiation. In patients undergoing hemopoietic stem ST:STUDY_SUMMARY cell transplantation, iron overload is a common risk factor for poor outcomes. ST:STUDY_SUMMARY Previous studies assert that both irradiation and iron independently modulate ST:STUDY_SUMMARY tryptophan and indole metabolism of the microbiome, which may in turn impact ST:STUDY_SUMMARY host immune response. However, no studies have interrogated the multi-organ ST:STUDY_SUMMARY effects of these treatments concurrently. Herein, we use a model that ST:STUDY_SUMMARY recapitulate transfusional iron overload, a condition often observed in ST:STUDY_SUMMARY chronically transfused patients with thalassemia, sickle cell disease, or ST:STUDY_SUMMARY myelodysplastic syndrome. We applied an omics approach to investigate the impact ST:STUDY_SUMMARY of both iron load and irradiation on the host metabolome. Our results revealed ST:STUDY_SUMMARY dose-dependent effects of irradiation in red blood cells (RBC), plasma, spleen, ST:STUDY_SUMMARY and liver energy and redox metabolism. Increases in polyamines and purine ST:STUDY_SUMMARY salvage metabolites were observed in organs with high oxygen consumption ST:STUDY_SUMMARY including the heart, kidney, and brain. Irradiation also impacted the metabolism ST:STUDY_SUMMARY of the duodenum, colon, and stool, suggesting a potential effect on the ST:STUDY_SUMMARY microbiome. Iron infusion affected the respose to radiation in the organs and ST:STUDY_SUMMARY blood, especially in RBC polyamine metabolism and spleen antioxidant metabolism, ST:STUDY_SUMMARY and affected glucose, sulfur (especially methionine and glutathione systems) and ST:STUDY_SUMMARY tryptophan metabolism in the liver, stool, and brain. Together, the results ST:STUDY_SUMMARY suggest that radiation impacts metabolism on a multi-organ level with a ST:STUDY_SUMMARY significant interaction of host iron status. ST:INSTITUTE University of Colorado Anschutz Medical Campus ST:LAST_NAME Roy ST:FIRST_NAME Micaela ST:ADDRESS 13001 E 17th Pl, Aurora, CO 80045 ST:EMAIL micaela.roy@cuanschutz.edu ST:PHONE 303-724-3339 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - 1 Treatment:Saline | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-1 SUBJECT_SAMPLE_FACTORS - 2 Treatment:Saline | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-2 SUBJECT_SAMPLE_FACTORS - 3 Treatment:Saline | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-3 SUBJECT_SAMPLE_FACTORS - 4 Treatment:Saline | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-4 SUBJECT_SAMPLE_FACTORS - 6 Treatment:IV iron | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-5 SUBJECT_SAMPLE_FACTORS - 7 Treatment:IV iron | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-6 SUBJECT_SAMPLE_FACTORS - 8 Treatment:IV iron | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-7 SUBJECT_SAMPLE_FACTORS - 9 Treatment:IV iron | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-8 SUBJECT_SAMPLE_FACTORS - 10 Treatment:IV iron | Radiation Dose:no irradiated RAW_FILE_NAME=AM4-9 SUBJECT_SAMPLE_FACTORS - 11 Treatment:Saline | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-10 SUBJECT_SAMPLE_FACTORS - 13 Treatment:Saline | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-11 SUBJECT_SAMPLE_FACTORS - 14 Treatment:Saline | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-12 SUBJECT_SAMPLE_FACTORS - 15 Treatment:Saline | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-13 SUBJECT_SAMPLE_FACTORS - 16 Treatment:IV iron | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-14 SUBJECT_SAMPLE_FACTORS - 17 Treatment:IV iron | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-15 SUBJECT_SAMPLE_FACTORS - 18 Treatment:IV iron | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-16 SUBJECT_SAMPLE_FACTORS - 19 Treatment:IV iron | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-17 SUBJECT_SAMPLE_FACTORS - 20 Treatment:IV iron | Radiation Dose:Gy7 RAW_FILE_NAME=AM4-18 SUBJECT_SAMPLE_FACTORS - 21 Treatment:Saline | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-19 SUBJECT_SAMPLE_FACTORS - 22 Treatment:Saline | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-20 SUBJECT_SAMPLE_FACTORS - 23 Treatment:Saline | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-21 SUBJECT_SAMPLE_FACTORS - 24 Treatment:Saline | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-22 SUBJECT_SAMPLE_FACTORS - 25 Treatment:Saline | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-23 SUBJECT_SAMPLE_FACTORS - 26 Treatment:IV iron | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-24 SUBJECT_SAMPLE_FACTORS - 27 Treatment:IV iron | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-25 SUBJECT_SAMPLE_FACTORS - 28 Treatment:IV iron | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-26 SUBJECT_SAMPLE_FACTORS - 29 Treatment:IV iron | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-27 SUBJECT_SAMPLE_FACTORS - 30 Treatment:IV iron | Radiation Dose:Gy8 RAW_FILE_NAME=AM4-28 SUBJECT_SAMPLE_FACTORS - 31 Treatment:Saline | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-29 SUBJECT_SAMPLE_FACTORS - 32 Treatment:Saline | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-30 SUBJECT_SAMPLE_FACTORS - 33 Treatment:Saline | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-31 SUBJECT_SAMPLE_FACTORS - 34 Treatment:Saline | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-32 SUBJECT_SAMPLE_FACTORS - 35 Treatment:Saline | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-33 SUBJECT_SAMPLE_FACTORS - 36 Treatment:IV iron | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-34 SUBJECT_SAMPLE_FACTORS - 37 Treatment:IV iron | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-35 SUBJECT_SAMPLE_FACTORS - 38 Treatment:IV iron | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-36 SUBJECT_SAMPLE_FACTORS - 39 Treatment:IV iron | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-37 SUBJECT_SAMPLE_FACTORS - 40 Treatment:IV iron | Radiation Dose:Gy9 RAW_FILE_NAME=AM4-38 SUBJECT_SAMPLE_FACTORS - 41 Treatment:Saline | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-39 SUBJECT_SAMPLE_FACTORS - 42 Treatment:Saline | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-40 SUBJECT_SAMPLE_FACTORS - 43 Treatment:Saline | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-41 SUBJECT_SAMPLE_FACTORS - 44 Treatment:Saline | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-42 SUBJECT_SAMPLE_FACTORS - 45 Treatment:Saline | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-43 SUBJECT_SAMPLE_FACTORS - 46 Treatment:IV iron | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-44 SUBJECT_SAMPLE_FACTORS - 47 Treatment:IV iron | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-45 SUBJECT_SAMPLE_FACTORS - 48 Treatment:IV iron | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-46 SUBJECT_SAMPLE_FACTORS - 49 Treatment:IV iron | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-47 SUBJECT_SAMPLE_FACTORS - 50 Treatment:IV iron | Radiation Dose:Gy10 RAW_FILE_NAME=AM4-48 SUBJECT_SAMPLE_FACTORS - 51 Treatment:Saline | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-49 SUBJECT_SAMPLE_FACTORS - 52 Treatment:Saline | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-50 SUBJECT_SAMPLE_FACTORS - 53 Treatment:Saline | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-51 SUBJECT_SAMPLE_FACTORS - 54 Treatment:Saline | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-52 SUBJECT_SAMPLE_FACTORS - 55 Treatment:Saline | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-53 SUBJECT_SAMPLE_FACTORS - 56 Treatment:IV iron | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-54 SUBJECT_SAMPLE_FACTORS - 57 Treatment:IV iron | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-55 SUBJECT_SAMPLE_FACTORS - 58 Treatment:IV iron | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-56 SUBJECT_SAMPLE_FACTORS - 59 Treatment:IV iron | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-57 SUBJECT_SAMPLE_FACTORS - 60 Treatment:IV iron | Radiation Dose:Gy11 RAW_FILE_NAME=AM4-58 #COLLECTION CO:COLLECTION_SUMMARY At day +4 post irradiation, mice were euthanized and blood was collected by CO:COLLECTION_SUMMARY cardiac puncture in heparinized syringe CO:SAMPLE_TYPE Blood (whole) #TREATMENT TR:TREATMENT_SUMMARY After one week of acclimatization in a pathogen-free facility, cohorts of mice TR:TREATMENT_SUMMARY were retro-orbitally infused with phosphate buffer saline (PBS) or 12.5 mg of TR:TREATMENT_SUMMARY iron dextran (Henry Shein Animal Health, Dublin, OH), twice a week for 2 weeks TR:TREATMENT_SUMMARY for a total of 50 mg of iron. After 2 days of rest, mice were then divided in TR:TREATMENT_SUMMARY groups and irradiated with 7, 8, 9, 10, 11 Gy of C-137 (n=5 per group). Total TR:TREATMENT_SUMMARY dose was split in 2 doses 3 hours apart. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY A volume of 50μl of RBC aliquots was extracted in either 450μl, respectively SP:SAMPLEPREP_SUMMARY of methanol:acetonitrile:water (5:3:2, v/v/v).29 After vortexing at 4°C for 30 SP:SAMPLEPREP_SUMMARY min, extracts were separated from the protein pellet by centrifugation for 10 SP:SAMPLEPREP_SUMMARY min at 10,000g at 4°C and stored at −80°C until analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Vanquish CH:COLUMN_NAME Phenomenex Kinetex C18 (150 x 2.1mm, 2.6 um) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Samples (10uL injection for cells, 20uL injection for SUPs) were introduced to MS:MS_COMMENTS the MS via electrospray ionization with the MS scanning in full MS mode (2 MS:MS_COMMENTS µscans) and ddMS2 (top15) over the range of 65-950 m/z. Technical replicates MS:MS_COMMENTS were injected every six to twelve samples to ensure instrument stability (Nemkov MS:MS_COMMENTS et al., 2019). Metabolites were manually selected integrated with Maven MS:MS_COMMENTS (Princeton University) in conjunction with the KEGG database. Peak quality was MS:MS_COMMENTS determined using blanks, technical mixes, and 13C abundance. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS peak area top MS_METABOLITE_DATA_START Samples 1 2 3 4 6 7 8 9 10 11 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 Factors Treatment:Saline | Radiation Dose:no irradiated Treatment:Saline | Radiation Dose:no irradiated Treatment:Saline | Radiation Dose:no irradiated Treatment:Saline | Radiation Dose:no irradiated Treatment:IV iron | Radiation Dose:no irradiated Treatment:IV iron | Radiation Dose:no irradiated Treatment:IV iron | Radiation Dose:no irradiated Treatment:IV iron | Radiation Dose:no irradiated Treatment:IV iron | Radiation Dose:no irradiated Treatment:Saline | Radiation Dose:Gy7 Treatment:Saline | Radiation Dose:Gy7 Treatment:Saline | Radiation Dose:Gy7 Treatment:Saline | Radiation Dose:Gy7 Treatment:IV iron | Radiation Dose:Gy7 Treatment:IV iron | Radiation Dose:Gy7 Treatment:IV iron | Radiation Dose:Gy7 Treatment:IV iron | Radiation Dose:Gy7 Treatment:IV iron | Radiation Dose:Gy7 Treatment:Saline | Radiation Dose:Gy8 Treatment:Saline | Radiation Dose:Gy8 Treatment:Saline | Radiation Dose:Gy8 Treatment:Saline | Radiation Dose:Gy8 Treatment:Saline | Radiation Dose:Gy8 Treatment:IV iron | Radiation Dose:Gy8 Treatment:IV iron | Radiation Dose:Gy8 Treatment:IV iron | Radiation Dose:Gy8 Treatment:IV iron | Radiation Dose:Gy8 Treatment:IV iron | Radiation Dose:Gy8 Treatment:Saline | Radiation Dose:Gy9 Treatment:Saline | Radiation Dose:Gy9 Treatment:Saline | Radiation Dose:Gy9 Treatment:Saline | Radiation Dose:Gy9 Treatment:Saline | Radiation Dose:Gy9 Treatment:IV iron | Radiation Dose:Gy9 Treatment:IV iron | Radiation Dose:Gy9 Treatment:IV iron | Radiation Dose:Gy9 Treatment:IV iron | Radiation Dose:Gy9 Treatment:IV iron | Radiation Dose:Gy9 Treatment:Saline | Radiation Dose:Gy10 Treatment:Saline | Radiation Dose:Gy10 Treatment:Saline | Radiation Dose:Gy10 Treatment:Saline | Radiation Dose:Gy10 Treatment:Saline | Radiation Dose:Gy10 Treatment:IV iron | Radiation Dose:Gy10 Treatment:IV iron | Radiation Dose:Gy10 Treatment:IV iron | Radiation Dose:Gy10 Treatment:IV iron | Radiation Dose:Gy10 Treatment:IV iron | Radiation Dose:Gy10 Treatment:Saline | Radiation Dose:Gy11 Treatment:Saline | Radiation Dose:Gy11 Treatment:Saline | Radiation Dose:Gy11 Treatment:Saline | Radiation Dose:Gy11 Treatment:Saline | Radiation Dose:Gy11 Treatment:IV iron | Radiation Dose:Gy11 Treatment:IV iron | Radiation Dose:Gy11 Treatment:IV iron | Radiation Dose:Gy11 Treatment:IV iron | Radiation Dose:Gy11 Treatment:IV iron | Radiation Dose:Gy11 L-alanine 1.28E+07 1.64E+07 2.00E+07 2.00E+07 1.44E+07 1.47E+07 2.05E+07 1.61E+07 1.95E+07 1.36E+07 2.39E+07 2.04E+07 9.49E+06 1.71E+07 2.00E+07 1.99E+07 2.00E+07 2.39E+07 1.46E+07 1.93E+07 1.38E+07 1.69E+07 2.01E+07 1.07E+07 1.36E+07 1.91E+07 1.58E+07 1.27E+07 1.82E+07 2.04E+07 2.20E+07 1.93E+07 2.54E+07 1.32E+07 5.03E+06 1.65E+07 1.73E+07 1.92E+07 1.43E+07 1.56E+07 2.02E+07 3.35E+07 3.69E+07 1.22E+07 1.62E+07 2.26E+07 2.39E+07 1.77E+07 2.18E+07 2.48E+07 1.31E+07 2.20E+07 2.18E+07 1.56E+07 1.27E+07 1.97E+07 2.37E+07 6.66E+06 L-arginine 3.98E+06 6.83E+06 5.85E+06 3.94E+06 2.61E+06 4.02E+06 3.38E+06 2.51E+06 3.56E+06 4.01E+06 5.11E+06 3.39E+06 1.97E+06 2.54E+06 3.84E+06 3.49E+06 2.83E+06 2.62E+06 4.24E+06 3.86E+06 2.54E+06 3.60E+06 3.70E+06 2.30E+06 2.39E+06 2.58E+06 2.49E+06 4.96E+05 4.45E+06 3.71E+06 3.55E+06 3.34E+06 3.26E+06 1.88E+06 2.35E+06 1.84E+06 2.85E+06 2.86E+06 4.81E+06 4.16E+06 3.84E+06 3.09E+06 3.40E+06 1.14E+06 2.63E+06 2.86E+06 2.92E+06 1.72E+06 4.35E+06 3.20E+06 4.42E+06 4.03E+06 2.94E+06 3.12E+06 1.95E+06 3.69E+06 2.03E+06 3.42E+06 L-asparagine 8.88E+05 1.56E+06 6.75E+05 8.41E+05 6.54E+05 4.77E+05 5.22E+05 5.21E+05 3.44E+05 4.79E+05 7.22E+05 7.08E+05 1.82E+05 3.31E+05 4.18E+05 4.79E+05 3.06E+05 4.60E+05 4.60E+05 4.99E+05 3.27E+05 3.63E+05 4.39E+05 4.84E+05 4.92E+05 4.08E+05 3.24E+05 6.61E+05 5.26E+05 6.24E+05 5.48E+05 5.66E+05 5.84E+05 4.51E+05 1.52E+06 7.18E+05 3.50E+05 4.42E+05 5.59E+05 7.52E+05 7.59E+05 9.03E+05 8.22E+05 7.71E+05 3.43E+05 5.21E+05 4.73E+05 4.14E+05 5.62E+05 5.69E+05 8.10E+05 4.07E+05 3.79E+05 4.49E+05 3.72E+05 6.42E+05 6.06E+05 1.40E+06 L-aspartate 1.43E+05 1.49E+05 2.00E+05 2.12E+05 1.34E+05 1.15E+05 1.56E+05 1.34E+05 1.24E+05 6.52E+04 4.14E+04 1.90E+05 6.02E+04 6.75E+04 9.77E+04 8.62E+04 6.95E+04 9.67E+04 1.30E+05 1.39E+05 5.98E+04 1.03E+05 1.14E+05 5.24E+04 1.13E+05 7.51E+04 8.36E+04 1.08E+05 4.63E+04 7.84E+04 2.18E+05 1.31E+05 1.18E+05 8.37E+04 2.89E+04 1.11E+05 8.13E+04 7.17E+04 9.09E+04 8.14E+04 1.52E+05 4.38E+05 2.84E+05 6.73E+04 8.64E+04 1.74E+05 2.10E+05 1.18E+05 1.16E+05 1.54E+05 1.17E+05 1.49E+05 7.87E+04 1.59E+05 1.10E+05 8.86E+04 1.31E+05 1.60E+05 L-glutamate 4.31E+06 3.63E+06 3.59E+06 2.69E+06 3.94E+06 3.11E+06 2.78E+06 2.35E+06 2.49E+06 2.52E+06 2.26E+06 2.40E+06 6.59E+05 2.29E+06 1.89E+06 2.06E+06 2.07E+06 1.81E+06 2.72E+06 2.12E+06 1.42E+06 1.86E+06 1.57E+06 2.65E+06 1.51E+06 1.50E+06 2.01E+06 1.13E+06 2.02E+06 1.61E+06 2.26E+06 1.27E+06 1.50E+06 1.62E+06 2.15E+06 2.22E+06 1.73E+06 1.42E+06 2.23E+06 1.87E+06 1.82E+06 2.22E+06 1.55E+06 2.12E+06 1.88E+06 2.00E+06 2.36E+06 1.40E+06 1.96E+06 1.63E+06 1.85E+06 1.65E+06 1.29E+06 1.56E+06 1.88E+06 1.80E+06 1.44E+06 2.07E+06 L-glutamine 9.96E+06 1.04E+07 9.48E+06 8.06E+06 9.63E+06 8.99E+06 8.75E+06 7.89E+06 9.03E+06 1.02E+07 8.42E+06 8.23E+06 4.92E+06 1.10E+07 9.20E+06 9.12E+06 9.45E+06 7.44E+06 1.10E+07 9.85E+06 5.31E+06 9.05E+06 1.00E+07 9.56E+06 8.93E+06 9.15E+06 7.28E+06 7.44E+06 8.99E+06 8.76E+06 7.52E+06 7.84E+06 8.51E+06 8.32E+06 7.40E+06 7.82E+06 5.87E+06 6.95E+06 9.86E+06 6.87E+06 7.08E+06 9.63E+06 1.00E+07 1.06E+07 7.51E+06 8.65E+06 8.93E+06 9.36E+06 8.40E+06 9.03E+06 7.07E+06 7.55E+06 6.64E+06 8.29E+06 8.25E+06 7.38E+06 9.12E+06 9.03E+06 L-histidine 3.22E+06 3.31E+06 3.35E+06 3.31E+06 2.08E+06 2.15E+06 1.93E+06 2.09E+06 2.48E+06 3.05E+06 3.57E+06 3.34E+06 1.49E+06 2.43E+06 2.43E+06 2.80E+06 2.39E+06 2.71E+06 2.62E+06 2.96E+06 2.29E+06 3.07E+06 3.65E+06 2.22E+06 2.03E+06 2.25E+06 2.31E+06 2.69E+06 3.06E+06 2.74E+06 3.76E+06 3.47E+06 2.66E+06 1.87E+06 9.31E+05 3.17E+06 2.13E+06 2.30E+06 3.24E+06 2.54E+06 3.23E+06 3.64E+06 3.04E+06 2.71E+06 1.79E+06 2.11E+06 2.78E+06 3.58E+06 2.73E+06 3.23E+06 2.33E+06 3.34E+06 2.55E+06 2.59E+06 1.94E+06 1.44E+06 2.05E+06 1.34E+06 L-leucine/isoleucine 1.45E+08 2.11E+08 1.14E+08 1.36E+08 1.33E+08 1.40E+08 1.22E+08 9.67E+07 9.82E+07 1.20E+08 1.58E+08 1.59E+08 3.85E+07 1.22E+08 1.25E+08 1.14E+08 1.01E+08 1.08E+08 8.66E+07 9.72E+07 6.45E+07 1.19E+08 1.03E+08 1.18E+08 9.86E+07 1.28E+08 7.35E+07 1.15E+08 1.13E+08 1.20E+08 1.06E+08 1.09E+08 1.05E+08 8.86E+07 9.74E+07 1.06E+08 1.24E+08 8.33E+07 1.14E+08 1.25E+08 1.47E+08 1.48E+08 1.36E+08 1.04E+08 1.22E+08 1.01E+08 1.09E+08 9.17E+07 1.00E+08 1.27E+08 8.29E+07 1.16E+08 7.56E+07 1.52E+08 1.38E+08 7.17E+07 8.77E+07 1.08E+08 L-lysine 1.84E+07 2.26E+07 1.68E+07 1.83E+07 1.24E+07 1.54E+07 9.05E+06 1.14E+07 1.30E+07 1.33E+07 1.59E+07 1.43E+07 5.99E+06 9.82E+06 1.61E+07 1.26E+07 1.22E+07 1.15E+07 1.67E+07 1.27E+07 1.07E+07 1.28E+07 1.60E+07 1.19E+07 9.32E+06 8.51E+06 1.09E+07 1.19E+07 1.38E+07 1.32E+07 1.76E+07 1.69E+07 1.40E+07 8.23E+06 8.51E+06 1.31E+07 1.08E+07 1.18E+07 1.42E+07 1.34E+07 1.58E+07 1.32E+07 1.49E+07 1.13E+07 8.56E+06 1.18E+07 1.32E+07 8.67E+06 1.24E+07 1.35E+07 1.67E+07 1.47E+07 1.01E+07 1.29E+07 9.86E+06 1.35E+07 1.10E+07 1.47E+07 L-methionine 3.15E+07 3.92E+07 2.76E+07 3.09E+07 2.48E+07 2.25E+07 3.11E+07 1.47E+07 1.65E+07 2.54E+07 3.08E+07 1.84E+07 8.03E+06 2.04E+07 1.99E+07 1.98E+07 2.07E+07 2.63E+07 1.60E+07 1.78E+07 1.42E+07 1.78E+07 1.72E+07 1.80E+07 1.40E+07 1.60E+07 1.18E+07 1.67E+07 3.34E+07 2.68E+07 2.21E+07 2.31E+07 2.33E+07 1.14E+07 6.50E+06 2.40E+07 1.59E+07 1.78E+07 2.58E+07 2.05E+07 2.46E+07 5.08E+07 4.13E+07 2.41E+07 1.60E+07 1.67E+07 1.93E+07 1.71E+07 2.72E+07 2.17E+07 1.30E+07 2.31E+07 1.92E+07 1.75E+07 1.39E+07 1.35E+07 1.49E+07 8.19E+06 L-phenylalanine 2.22E+07 2.47E+07 1.45E+07 1.83E+07 1.88E+07 1.98E+07 1.75E+07 1.53E+07 1.39E+07 1.92E+07 2.17E+07 2.04E+07 5.48E+06 1.89E+07 1.65E+07 1.86E+07 1.62E+07 1.61E+07 1.36E+07 1.95E+07 1.02E+07 1.89E+07 1.38E+07 2.21E+07 1.47E+07 1.88E+07 1.27E+07 1.84E+07 1.70E+07 1.83E+07 1.50E+07 1.44E+07 1.39E+07 1.29E+07 1.38E+07 2.29E+07 1.62E+07 1.42E+07 1.84E+07 1.80E+07 1.87E+07 2.01E+07 1.99E+07 2.56E+07 1.74E+07 1.58E+07 1.62E+07 2.05E+07 1.68E+07 1.90E+07 1.03E+07 1.87E+07 1.25E+07 1.98E+07 2.09E+07 1.15E+07 1.41E+07 1.55E+07 L-proline 4.57E+07 6.36E+07 5.69E+07 5.62E+07 4.27E+07 4.04E+07 4.52E+07 3.68E+07 4.04E+07 4.74E+07 6.70E+07 4.54E+07 2.19E+07 4.46E+07 4.64E+07 4.47E+07 3.97E+07 4.40E+07 3.73E+07 4.68E+07 3.25E+07 3.78E+07 4.37E+07 2.88E+07 3.46E+07 3.35E+07 3.02E+07 3.58E+07 6.01E+07 5.19E+07 5.32E+07 4.87E+07 5.26E+07 2.83E+07 1.81E+07 5.38E+07 3.83E+07 3.83E+07 4.47E+07 4.91E+07 5.38E+07 9.21E+07 6.87E+07 5.65E+07 3.53E+07 4.61E+07 5.01E+07 5.00E+07 6.05E+07 5.79E+07 3.99E+07 5.65E+07 4.44E+07 4.15E+07 2.90E+07 4.03E+07 4.72E+07 2.24E+07 L-serine 9.09E+05 1.09E+06 8.79E+05 7.91E+05 5.84E+05 6.73E+05 8.46E+05 6.06E+05 6.79E+05 7.39E+05 1.07E+06 7.03E+05 3.95E+05 6.08E+05 7.03E+05 6.63E+05 6.34E+05 7.10E+05 7.74E+05 9.22E+05 5.60E+05 7.58E+05 1.00E+06 5.33E+05 5.76E+05 5.92E+05 6.05E+05 6.21E+05 9.45E+05 8.57E+05 8.12E+05 9.23E+05 1.13E+06 5.06E+05 3.19E+05 6.53E+05 5.36E+05 5.57E+05 7.24E+05 6.17E+05 7.60E+05 1.17E+06 1.02E+06 7.33E+05 5.10E+05 6.27E+05 7.18E+05 6.54E+05 9.11E+05 9.38E+05 4.79E+05 8.77E+05 8.45E+05 6.76E+05 5.86E+05 4.88E+05 5.10E+05 3.02E+05 L-threonine 3.36E+06 5.05E+06 4.25E+06 3.02E+06 2.23E+06 2.40E+06 3.31E+06 1.99E+06 2.33E+06 3.07E+06 5.09E+06 2.87E+06 1.84E+06 2.18E+06 2.74E+06 2.12E+06 2.20E+06 2.78E+06 2.67E+06 2.51E+06 2.00E+06 2.79E+06 2.99E+06 1.81E+06 1.98E+06 1.82E+06 1.73E+06 2.67E+06 4.28E+06 4.06E+06 3.71E+06 3.43E+06 4.89E+06 1.88E+06 1.80E+06 1.81E+06 1.86E+06 2.16E+06 3.23E+06 2.75E+06 3.10E+06 6.85E+06 4.85E+06 2.24E+06 1.66E+06 1.96E+06 2.28E+06 1.98E+06 3.43E+06 3.52E+06 2.61E+06 3.38E+06 3.04E+06 2.77E+06 2.62E+06 2.17E+06 2.21E+06 2.40E+06 L-tryptophan 9.77E+07 9.13E+07 1.06E+08 5.95E+07 7.61E+07 7.97E+07 4.91E+07 4.95E+07 7.56E+07 1.20E+08 1.59E+08 9.93E+07 8.93E+07 9.17E+07 1.17E+08 8.08E+07 1.18E+08 7.74E+07 7.11E+07 8.56E+07 7.50E+07 7.01E+07 7.53E+07 6.42E+07 8.42E+07 5.91E+07 6.15E+07 8.29E+07 1.44E+08 9.52E+07 1.46E+08 1.02E+08 1.15E+08 7.59E+07 6.16E+07 9.71E+07 9.83E+07 6.74E+07 1.16E+08 1.25E+08 9.98E+07 9.74E+07 9.08E+07 1.16E+08 7.46E+07 7.75E+07 5.94E+07 7.85E+07 9.82E+07 9.49E+07 1.53E+08 9.89E+07 7.51E+07 7.98E+07 4.90E+07 7.12E+07 5.83E+07 4.47E+07 L-tyrosine 2.35E+07 2.54E+07 1.75E+07 1.62E+07 1.46E+07 1.20E+07 1.20E+07 8.03E+06 1.04E+07 1.76E+07 2.11E+07 1.85E+07 7.15E+06 1.41E+07 1.38E+07 1.29E+07 1.28E+07 9.34E+06 1.34E+07 2.12E+07 7.49E+06 1.31E+07 1.64E+07 1.57E+07 1.41E+07 1.38E+07 1.00E+07 2.11E+07 1.73E+07 1.76E+07 1.45E+07 1.33E+07 1.43E+07 1.08E+07 4.34E+06 2.39E+07 1.33E+07 9.63E+06 1.77E+07 1.47E+07 1.73E+07 2.75E+07 2.56E+07 2.68E+07 1.13E+07 1.33E+07 1.28E+07 2.21E+07 1.62E+07 1.96E+07 8.12E+06 1.69E+07 1.04E+07 1.50E+07 1.29E+07 4.58E+06 4.66E+06 4.47E+06 L-valine 1.34E+08 1.96E+08 1.29E+08 1.29E+08 1.27E+08 1.25E+08 1.19E+08 9.74E+07 9.71E+07 1.33E+08 1.61E+08 1.39E+08 7.36E+07 1.12E+08 1.18E+08 1.09E+08 9.46E+07 1.13E+08 1.09E+08 1.16E+08 7.44E+07 1.14E+08 1.09E+08 1.10E+08 9.54E+07 1.18E+08 7.41E+07 1.21E+08 1.29E+08 1.50E+08 1.41E+08 1.21E+08 1.20E+08 8.61E+07 8.72E+07 1.19E+08 1.11E+08 1.05E+08 1.49E+08 1.38E+08 1.39E+08 1.71E+08 1.44E+08 1.36E+08 1.08E+08 1.01E+08 1.24E+08 1.26E+08 1.31E+08 1.33E+08 1.03E+08 1.35E+08 1.04E+08 1.29E+08 1.09E+08 8.18E+07 8.80E+07 8.58E+07 L-cystine 3.04E+04 1.89E+04 3.57E+04 4.08E+04 1.18E+04 3.98E+04 3.59E+04 2.69E+04 3.79E+04 3.50E+04 4.43E+04 3.66E+04 3.20E+04 4.49E+04 4.08E+04 3.95E+04 6.87E+04 4.31E+04 3.82E+04 3.30E+04 2.32E+04 3.06E+04 4.33E+04 4.17E+04 3.49E+04 3.13E+04 4.74E+04 2.29E+04 1.92E+04 2.42E+04 5.19E+04 2.15E+04 7.30E+04 3.48E+04 5.34E+04 3.79E+04 2.41E+04 3.70E+04 4.13E+04 5.08E+04 5.62E+04 7.96E+04 5.44E+04 1.43E+04 5.87E+04 5.45E+04 3.37E+04 1.44E+04 3.98E+04 4.45E+04 4.46E+04 5.20E+04 3.74E+04 4.97E+04 4.74E+04 4.73E+04 5.93E+04 5.98E+04 Adenosine 1.44E+05 1.30E+05 1.77E+05 1.42E+05 1.64E+05 1.67E+05 1.37E+05 1.35E+05 1.84E+05 1.40E+05 1.42E+05 1.46E+05 1.62E+05 1.05E+05 1.84E+05 1.44E+05 1.90E+05 0.00E+00 1.38E+05 1.18E+05 1.79E+05 1.36E+05 1.47E+05 1.16E+05 1.41E+05 1.48E+05 3.44E+05 1.31E+05 1.44E+05 1.27E+05 1.41E+05 1.32E+05 2.51E+05 1.45E+05 1.42E+05 1.44E+05 1.61E+05 1.18E+05 1.26E+05 1.42E+05 1.43E+05 1.31E+05 1.28E+05 1.03E+05 2.03E+05 1.20E+05 1.87E+05 1.22E+05 1.06E+05 1.28E+05 1.68E+05 1.41E+05 1.06E+05 1.43E+05 1.54E+05 1.45E+05 1.36E+05 1.22E+05 Guanine 4.84E+04 3.76E+04 5.24E+04 3.06E+04 6.54E+04 5.71E+04 5.06E+04 4.93E+04 7.86E+04 6.98E+04 4.04E+04 5.32E+04 5.76E+04 5.53E+04 5.85E+04 6.85E+04 5.23E+04 4.87E+04 6.32E+04 4.27E+04 7.90E+04 4.74E+04 4.74E+04 6.80E+04 5.92E+04 5.03E+04 6.68E+04 3.24E+04 5.73E+04 5.19E+04 5.57E+04 3.34E+04 3.30E+04 5.82E+04 8.87E+04 4.82E+04 8.98E+04 5.55E+04 5.35E+04 4.47E+04 4.66E+04 2.72E+04 2.89E+04 4.58E+04 7.08E+04 5.20E+04 5.40E+04 3.08E+04 4.68E+04 4.54E+04 5.46E+04 3.92E+04 3.31E+04 5.97E+04 5.68E+04 5.68E+04 3.95E+04 7.78E+04 Cytidine 4.93E+05 3.08E+05 1.90E+05 8.58E+04 3.50E+05 2.70E+05 1.38E+05 1.37E+05 1.27E+05 2.19E+05 1.70E+05 1.67E+05 3.52E+04 2.19E+05 9.21E+04 1.01E+05 8.70E+04 7.09E+04 2.07E+05 2.10E+05 4.55E+04 1.21E+05 9.70E+04 2.51E+05 1.56E+05 1.32E+05 1.11E+05 1.23E+05 1.30E+05 8.02E+04 1.05E+05 5.82E+04 5.29E+04 1.41E+05 2.02E+05 1.39E+05 8.96E+04 4.88E+04 1.34E+05 9.98E+04 7.25E+04 1.09E+05 9.10E+04 1.82E+05 1.44E+05 1.40E+05 1.38E+05 8.57E+04 1.47E+05 1.23E+05 1.10E+05 8.15E+04 2.95E+04 1.41E+05 1.36E+05 1.06E+05 1.68E+05 1.47E+05 Cytosine 6.58E+05 4.85E+05 3.79E+05 2.98E+05 4.78E+05 3.75E+05 2.25E+05 3.95E+05 2.72E+05 2.64E+05 2.47E+05 2.42E+05 3.80E+04 2.53E+05 1.73E+05 1.79E+05 1.46E+05 1.36E+05 2.26E+05 2.48E+05 1.22E+05 1.85E+05 1.45E+05 2.73E+05 1.62E+05 1.59E+05 1.45E+05 1.58E+05 1.98E+05 1.70E+05 1.34E+05 1.79E+05 1.20E+05 1.86E+05 2.53E+05 1.95E+05 1.92E+05 1.87E+05 2.07E+05 1.94E+05 1.42E+05 2.74E+05 1.68E+05 1.84E+05 1.77E+05 1.73E+05 2.31E+05 1.61E+05 2.30E+05 2.44E+05 1.58E+05 1.45E+05 1.08E+05 1.88E+05 1.80E+05 1.88E+05 2.25E+05 1.54E+05 IMP 6.21E+06 4.95E+06 3.72E+06 3.50E+06 6.23E+06 6.68E+06 2.51E+06 4.65E+06 4.59E+06 5.61E+06 4.11E+06 4.52E+06 5.17E+05 5.36E+06 3.86E+06 5.11E+06 2.76E+06 2.26E+06 5.23E+06 2.71E+06 2.05E+06 4.36E+06 3.31E+06 6.31E+06 3.76E+06 2.17E+06 1.99E+06 1.13E+06 2.94E+06 2.93E+06 3.52E+06 1.98E+06 1.32E+06 4.56E+06 4.80E+06 3.47E+06 5.24E+06 2.22E+06 3.49E+06 2.06E+06 3.49E+06 2.53E+06 1.23E+06 5.27E+06 3.53E+06 1.90E+06 3.36E+06 5.51E+05 5.06E+06 4.96E+06 3.01E+06 3.07E+06 1.01E+06 3.95E+06 3.74E+06 1.97E+06 5.67E+05 2.37E+06 Inosine 3.58E+06 3.50E+06 1.43E+06 7.88E+05 1.46E+06 1.51E+06 3.70E+05 4.87E+05 3.68E+05 1.41E+06 5.23E+05 4.80E+05 1.30E+04 6.12E+05 1.60E+05 1.68E+05 6.53E+04 0.00E+00 7.52E+05 3.28E+05 1.05E+05 3.23E+05 1.71E+05 3.88E+05 1.16E+05 5.89E+04 1.63E+04 0.00E+00 1.30E+06 1.02E+06 4.85E+05 1.81E+05 2.28E+05 7.45E+05 9.90E+05 1.94E+05 3.50E+05 3.30E+04 8.63E+05 4.45E+05 4.14E+05 3.11E+05 3.60E+04 7.54E+05 5.97E+04 1.51E+04 1.11E+05 0.00E+00 1.03E+06 5.56E+05 1.64E+05 1.41E+05 0.00E+00 1.94E+05 6.45E+04 2.51E+04 0.00E+00 2.08E+04 Hypoxanthine 7.92E+07 8.60E+07 4.74E+07 3.57E+07 5.23E+07 4.49E+07 1.50E+07 2.02E+07 1.88E+07 6.37E+07 3.08E+07 3.29E+07 4.66E+06 2.88E+07 1.27E+07 1.40E+07 5.04E+06 2.51E+06 3.83E+07 1.32E+07 7.36E+06 2.00E+07 1.02E+07 2.30E+07 8.01E+06 2.73E+06 1.86E+06 6.71E+05 4.34E+07 3.82E+07 2.99E+07 1.26E+07 1.31E+07 2.66E+07 3.68E+07 1.41E+07 1.92E+07 3.18E+06 4.14E+07 2.27E+07 2.57E+07 1.89E+07 2.80E+06 3.61E+07 7.54E+06 3.36E+06 6.66E+06 3.77E+05 3.19E+07 2.82E+07 1.51E+07 1.30E+07 1.89E+06 1.13E+07 5.81E+06 2.57E+06 5.84E+05 2.91E+06 Xanthine 4.56E+06 3.52E+06 3.71E+06 2.70E+06 4.75E+06 4.13E+06 2.11E+06 2.64E+06 2.93E+06 3.51E+06 2.14E+06 2.64E+06 8.62E+05 2.66E+06 1.65E+06 2.12E+06 9.94E+05 5.30E+05 2.61E+06 1.61E+06 1.19E+06 1.66E+06 1.18E+06 2.12E+06 1.18E+06 7.59E+05 3.64E+05 4.83E+04 2.69E+06 2.58E+06 2.82E+06 1.59E+06 2.10E+06 2.97E+06 2.35E+06 2.31E+06 2.41E+06 8.28E+05 2.71E+06 1.95E+06 2.45E+06 1.48E+06 6.23E+05 3.41E+06 1.39E+06 8.09E+05 1.18E+06 1.36E+04 1.86E+06 2.13E+06 1.51E+06 1.49E+06 4.80E+05 1.32E+06 1.06E+06 4.96E+05 1.73E+04 5.24E+05 Allantoate 1.90E+05 2.75E+05 3.22E+05 3.00E+05 2.40E+05 2.78E+05 3.40E+05 2.78E+05 3.04E+05 2.45E+05 3.62E+05 4.39E+05 2.13E+05 3.12E+05 2.92E+05 2.37E+05 2.50E+05 2.95E+05 3.42E+05 2.63E+05 2.92E+05 3.12E+05 3.20E+05 2.40E+05 2.19E+05 2.12E+05 3.27E+05 5.55E+05 3.81E+05 3.70E+05 6.70E+05 4.10E+05 4.27E+05 3.98E+05 1.53E+05 5.30E+05 4.44E+05 3.61E+05 4.36E+05 3.22E+05 3.87E+05 6.60E+05 4.75E+05 4.88E+05 2.92E+05 3.13E+05 4.80E+05 5.64E+05 2.78E+05 4.02E+05 2.57E+05 3.76E+05 3.08E+05 3.85E+05 2.70E+05 2.75E+05 4.77E+05 2.44E+05 5-Hydroxyisourate 1.55E+06 1.56E+06 1.32E+06 1.25E+06 1.38E+06 1.22E+06 9.61E+05 1.04E+06 1.22E+06 1.17E+06 9.85E+05 9.38E+05 2.92E+05 1.12E+06 1.02E+06 8.95E+05 8.92E+05 9.10E+05 1.52E+06 1.01E+06 5.11E+05 1.02E+06 1.18E+06 1.43E+06 8.89E+05 1.02E+06 8.16E+05 8.86E+05 9.53E+05 9.15E+05 6.93E+05 1.16E+06 8.25E+05 8.65E+05 9.21E+05 9.88E+05 6.27E+05 7.94E+05 1.01E+06 7.53E+05 7.65E+05 9.80E+05 9.27E+05 9.93E+05 8.66E+05 8.53E+05 1.14E+06 1.12E+06 1.03E+06 9.90E+05 9.49E+05 8.72E+05 7.49E+05 1.08E+06 9.25E+05 9.56E+05 1.21E+06 1.18E+06 3',5'-Cyclic AMP 1.61E+05 2.33E+05 1.46E+05 1.76E+05 1.84E+05 2.06E+05 1.04E+05 1.50E+05 1.31E+05 1.25E+05 1.20E+05 1.26E+05 0.00E+00 1.04E+05 6.96E+04 8.00E+04 7.73E+04 6.94E+04 9.79E+04 1.29E+05 5.60E+04 1.20E+05 1.65E+05 1.05E+05 8.78E+04 8.83E+04 7.49E+04 8.34E+04 3.62E+04 8.12E+04 6.16E+04 1.68E+05 5.70E+04 4.52E+04 1.08E+05 8.75E+04 6.16E+04 6.60E+04 6.76E+04 7.11E+04 9.70E+04 1.19E+05 7.91E+04 1.14E+05 6.41E+04 7.51E+04 1.38E+05 4.99E+04 1.04E+05 1.07E+05 1.05E+05 1.03E+05 2.79E+04 1.19E+05 1.02E+05 7.63E+04 1.08E+05 6.65E+04 2',3'-Cyclic CMP 3.46E+04 4.30E+04 5.02E+04 5.25E+04 5.84E+04 5.27E+04 4.16E+04 5.25E+04 3.04E+04 5.57E+04 3.41E+04 6.50E+04 2.61E+04 3.19E+04 5.75E+04 5.94E+04 5.17E+04 5.25E+04 2.41E+04 4.52E+04 2.88E+04 5.03E+04 4.80E+04 4.37E+04 3.56E+04 5.52E+04 3.36E+04 3.19E+04 3.83E+04 3.42E+04 1.91E+04 3.84E+04 4.30E+04 4.66E+04 2.30E+04 4.91E+04 4.80E+04 2.63E+04 6.53E+04 3.04E+04 4.86E+04 3.29E+04 5.74E+04 4.69E+04 4.76E+04 2.79E+04 4.76E+04 4.08E+04 4.93E+04 6.31E+04 2.08E+04 4.50E+04 2.44E+04 2.88E+04 4.05E+04 3.57E+04 3.78E+04 4.80E+03 5-6-Dihydrothymine 3.83E+05 3.17E+05 3.19E+05 2.99E+05 4.05E+05 2.82E+05 2.83E+05 3.52E+05 2.97E+05 2.39E+05 2.49E+05 2.50E+05 1.18E+05 3.07E+05 2.60E+05 2.07E+05 1.98E+05 2.35E+05 1.94E+05 1.97E+05 1.38E+05 2.00E+05 2.13E+05 3.78E+05 2.13E+05 2.49E+05 2.09E+05 2.07E+05 3.44E+05 2.42E+05 2.23E+05 2.13E+05 2.35E+05 2.66E+05 1.50E+05 2.73E+05 1.86E+05 3.05E+05 2.25E+05 2.70E+05 2.43E+05 3.62E+05 3.23E+05 3.08E+05 2.86E+05 2.49E+05 2.95E+05 2.80E+05 3.16E+05 2.53E+05 1.94E+05 2.20E+05 2.54E+05 3.32E+05 2.93E+05 1.55E+05 2.28E+05 1.34E+05 Pyridoxamine 5'-phosphate 1.72E+05 1.81E+05 3.71E+05 2.20E+05 1.44E+05 1.77E+05 3.47E+05 2.29E+05 1.78E+05 2.30E+05 6.77E+05 2.04E+05 3.88E+05 3.23E+05 1.87E+05 1.84E+05 3.15E+05 2.23E+05 1.95E+05 6.20E+05 2.77E+05 3.37E+05 3.46E+05 2.22E+05 2.55E+05 5.37E+05 2.59E+05 1.86E+05 2.95E+05 6.47E+05 3.37E+05 1.80E+05 4.25E+05 2.11E+05 3.66E+05 2.31E+05 2.63E+05 6.01E+05 6.57E+05 6.93E+05 2.55E+05 4.30E+05 4.05E+05 2.53E+05 3.25E+05 2.31E+05 2.07E+05 4.49E+05 3.63E+05 2.49E+05 2.07E+05 2.84E+05 4.70E+05 2.01E+05 1.70E+05 2.45E+05 3.02E+05 2.39E+05 Nicotinamide 4.00E+07 3.89E+07 2.78E+07 2.88E+07 3.32E+07 3.28E+07 3.14E+07 2.58E+07 2.60E+07 2.58E+07 2.47E+07 2.46E+07 8.38E+06 2.52E+07 2.13E+07 2.10E+07 2.32E+07 2.19E+07 2.50E+07 2.01E+07 1.85E+07 2.67E+07 2.37E+07 2.59E+07 2.29E+07 2.64E+07 2.04E+07 2.00E+07 2.13E+07 2.23E+07 1.78E+07 1.76E+07 1.73E+07 1.52E+07 2.09E+07 2.48E+07 1.99E+07 1.70E+07 2.26E+07 1.98E+07 2.22E+07 2.19E+07 2.11E+07 2.02E+07 2.31E+07 2.06E+07 2.38E+07 1.77E+07 2.15E+07 2.29E+07 2.08E+07 2.04E+07 1.52E+07 2.20E+07 2.00E+07 2.26E+07 2.36E+07 2.50E+07 NADP+ 8.08E+04 1.24E+05 1.08E+05 1.49E+05 1.13E+05 1.08E+05 9.76E+04 1.37E+05 1.06E+05 8.90E+04 1.21E+05 9.63E+04 5.73E+04 9.36E+04 1.03E+05 1.04E+05 8.22E+04 1.07E+05 1.01E+05 1.20E+05 7.92E+04 1.16E+05 1.33E+05 9.99E+04 1.09E+05 1.10E+05 1.04E+05 1.16E+05 7.76E+04 9.12E+04 6.93E+04 1.80E+05 1.19E+05 9.44E+04 1.02E+05 9.32E+04 9.09E+04 1.11E+05 1.08E+05 1.01E+05 1.10E+05 1.45E+05 1.16E+05 1.17E+05 1.11E+05 9.90E+04 1.30E+05 1.26E+05 1.07E+05 8.90E+04 9.35E+04 9.38E+04 1.39E+05 9.37E+04 9.98E+04 9.95E+04 1.43E+05 7.98E+04 NAD+ 1.03E+05 3.36E+05 2.57E+05 3.90E+05 3.18E+05 3.48E+05 1.39E+05 3.66E+05 2.96E+05 2.16E+05 1.81E+05 1.82E+05 5.87E+04 2.08E+05 1.69E+05 2.34E+05 1.65E+05 3.41E+05 1.74E+05 2.32E+05 1.08E+05 2.31E+05 2.73E+05 3.00E+05 2.54E+05 2.27E+05 1.56E+05 3.00E+05 1.19E+05 2.07E+05 1.13E+05 3.96E+05 2.33E+05 2.45E+05 2.23E+05 4.01E+05 2.57E+05 2.56E+05 1.31E+05 2.17E+05 2.41E+05 3.00E+05 2.50E+05 4.15E+05 2.18E+05 2.10E+05 3.23E+05 2.83E+05 1.95E+05 1.59E+05 2.26E+05 2.09E+05 2.11E+05 1.71E+05 2.27E+05 2.46E+05 2.93E+05 1.66E+05 Phosphate 8.19E+06 1.10E+07 1.10E+07 1.57E+07 1.22E+07 1.22E+07 8.67E+06 1.13E+07 1.63E+07 1.44E+07 1.60E+07 2.24E+07 1.71E+07 1.24E+07 1.46E+07 2.00E+07 1.73E+07 2.54E+07 1.56E+07 1.17E+07 1.57E+07 1.51E+07 1.44E+07 1.65E+07 1.68E+07 1.11E+07 2.07E+07 2.50E+07 1.27E+07 1.07E+07 1.82E+07 2.14E+07 1.83E+07 1.55E+07 1.35E+07 2.42E+07 1.82E+07 1.63E+07 1.39E+07 1.37E+07 1.72E+07 1.45E+07 1.90E+07 1.71E+07 1.55E+07 2.22E+07 2.05E+07 2.03E+07 1.13E+07 1.55E+07 1.67E+07 1.61E+07 1.60E+07 1.55E+07 1.59E+07 2.01E+07 2.14E+07 2.46E+07 Glutathione disulfide 1.77E+07 2.65E+07 1.80E+07 1.90E+07 1.97E+07 1.84E+07 1.38E+07 1.58E+07 1.39E+07 1.42E+07 1.31E+07 1.33E+07 4.05E+06 1.36E+07 1.00E+07 1.46E+07 1.18E+07 1.42E+07 1.26E+07 1.18E+07 8.12E+06 1.40E+07 1.23E+07 1.59E+07 1.22E+07 1.10E+07 1.18E+07 7.49E+06 1.07E+07 1.03E+07 1.08E+07 1.62E+07 1.08E+07 1.01E+07 1.38E+07 1.30E+07 1.34E+07 1.11E+07 1.06E+07 1.05E+07 1.26E+07 1.46E+07 1.18E+07 1.24E+07 1.25E+07 1.08E+07 1.50E+07 8.38E+06 1.38E+07 1.22E+07 1.27E+07 1.13E+07 9.12E+06 1.26E+07 1.16E+07 1.19E+07 1.33E+07 1.07E+07 5-Oxoproline 1.03E+07 8.88E+06 7.44E+06 8.01E+06 1.07E+07 8.95E+06 6.69E+06 7.52E+06 6.15E+06 1.04E+07 6.36E+06 7.97E+06 2.61E+06 8.59E+06 7.25E+06 6.99E+06 6.31E+06 5.27E+06 9.37E+06 7.92E+06 3.87E+06 6.49E+06 7.39E+06 8.96E+06 6.75E+06 6.55E+06 5.33E+06 5.68E+06 7.81E+06 6.47E+06 5.49E+06 5.64E+06 5.92E+06 6.46E+06 5.78E+06 5.50E+06 5.70E+06 6.10E+06 6.97E+06 6.17E+06 6.15E+06 7.69E+06 7.37E+06 8.89E+06 5.36E+06 6.32E+06 8.44E+06 6.76E+06 5.90E+06 7.62E+06 5.81E+06 5.36E+06 4.85E+06 5.90E+06 6.09E+06 7.44E+06 6.27E+06 6.38E+06 S-Glutathionyl-L-cysteine 5.60E+05 5.71E+05 5.41E+05 6.50E+05 5.33E+05 6.25E+05 4.35E+05 5.97E+05 5.76E+05 5.54E+05 7.20E+05 7.09E+05 2.40E+05 4.86E+05 5.55E+05 5.02E+05 5.33E+05 6.17E+05 5.40E+05 4.77E+05 4.69E+05 5.67E+05 6.40E+05 6.46E+05 4.13E+05 4.92E+05 6.07E+05 3.21E+05 4.48E+05 7.38E+05 6.74E+05 5.71E+05 5.74E+05 4.25E+05 5.09E+05 5.10E+05 5.34E+05 4.95E+05 7.55E+05 6.17E+05 7.47E+05 5.83E+05 6.14E+05 3.64E+05 5.83E+05 6.26E+05 5.82E+05 5.06E+05 4.93E+05 5.58E+05 5.62E+05 5.90E+05 5.99E+05 6.30E+05 5.89E+05 5.12E+05 5.36E+05 5.40E+05 gamma-Glutamyl-gamma-aminobutyrate 7.78E+04 4.70E+04 3.46E+04 9.87E+04 9.50E+04 1.03E+05 5.24E+04 6.60E+04 5.69E+04 1.19E+05 6.53E+04 5.45E+04 8.19E+03 1.08E+05 3.14E+04 1.09E+05 2.80E+04 5.70E+04 6.05E+04 6.50E+04 5.32E+04 5.02E+04 3.53E+04 1.10E+05 5.56E+04 6.39E+04 6.10E+04 6.04E+04 1.09E+05 4.80E+04 6.15E+04 7.94E+04 1.97E+04 1.22E+05 1.11E+05 6.18E+04 5.37E+04 5.27E+04 6.17E+04 7.75E+04 6.00E+04 4.35E+04 4.63E+04 9.45E+04 9.80E+04 6.82E+04 8.64E+04 5.20E+04 1.07E+05 9.11E+04 6.53E+04 4.91E+04 3.56E+04 8.49E+04 9.99E+04 9.89E+04 1.01E+05 1.68E+05 L-Homocysteine 9.87E+04 8.24E+04 2.55E+03 2.86E+04 7.22E+04 7.90E+04 1.75E+04 1.98E+04 4.06E+04 9.55E+04 1.00E+05 8.79E+04 1.96E+04 3.43E+04 2.79E+04 3.03E+04 2.67E+04 2.11E+04 1.54E+05 7.51E+04 3.61E+04 6.61E+04 1.13E+05 1.18E+05 1.18E+05 8.74E+04 7.71E+04 9.12E+04 7.48E+04 1.10E+05 9.41E+04 9.53E+04 5.87E+04 7.23E+04 1.34E+05 5.69E+04 5.96E+04 3.29E+04 9.79E+04 1.52E+04 7.74E+04 1.10E+04 6.70E+04 9.53E+04 7.79E+04 1.29E+05 6.85E+04 5.52E+04 1.33E+05 1.36E+05 1.01E+05 7.13E+04 3.02E+04 1.33E+05 1.94E+05 1.41E+05 8.82E+04 1.24E+05 Dimethylglycine 1.52E+06 1.68E+06 1.18E+06 1.23E+06 1.10E+06 1.05E+06 1.19E+06 1.20E+06 1.24E+06 1.26E+06 1.55E+06 1.28E+06 4.94E+05 8.03E+05 8.03E+05 9.30E+05 9.09E+05 1.01E+06 1.22E+06 1.50E+06 7.22E+05 9.51E+05 1.38E+06 1.47E+06 1.47E+06 1.20E+06 1.10E+06 1.95E+06 1.46E+06 1.47E+06 1.45E+06 1.19E+06 1.58E+06 9.75E+05 1.30E+06 1.33E+06 1.27E+06 1.32E+06 1.68E+06 1.04E+06 1.67E+06 1.97E+06 1.77E+06 1.34E+06 1.02E+06 1.25E+06 1.24E+06 1.99E+06 1.78E+06 1.70E+06 1.06E+06 1.19E+06 1.17E+06 1.18E+06 2.45E+06 1.55E+06 1.42E+06 2.63E+06 S-Adenosyl-L-methionine 5.36E+04 8.11E+04 7.18E+04 5.73E+04 6.31E+04 3.10E+04 5.20E+04 4.90E+04 3.27E+04 5.18E+04 3.50E+04 4.91E+04 1.30E+04 3.11E+04 4.06E+04 3.32E+04 3.91E+04 5.33E+04 3.69E+04 4.11E+04 3.02E+04 3.35E+04 4.63E+04 4.17E+04 2.92E+04 3.75E+04 3.07E+04 1.88E+04 2.87E+04 4.53E+04 2.81E+04 5.64E+04 3.58E+04 1.12E+04 3.45E+04 4.36E+04 2.95E+04 1.95E+04 4.28E+04 4.17E+04 2.52E+04 5.18E+04 4.31E+04 1.79E+04 2.70E+04 4.51E+04 2.90E+04 4.84E+04 3.40E+04 5.13E+04 2.31E+04 2.91E+04 3.94E+04 4.91E+04 3.69E+04 2.88E+04 3.19E+04 2.04E+04 Ornithine 1.50E+06 1.99E+06 1.61E+06 1.55E+06 1.52E+06 1.68E+06 8.80E+05 1.13E+06 2.00E+06 1.38E+06 1.67E+06 2.24E+06 6.65E+05 1.36E+06 1.55E+06 1.34E+06 1.11E+06 1.36E+06 1.66E+06 6.47E+05 8.81E+05 1.39E+06 1.47E+06 1.15E+06 9.35E+05 5.65E+05 1.22E+06 3.45E+06 1.85E+06 1.11E+06 3.51E+06 2.13E+06 1.96E+06 2.09E+06 5.27E+05 2.47E+06 1.70E+06 1.42E+06 1.36E+06 1.09E+06 1.77E+06 2.56E+06 1.78E+06 2.59E+06 9.86E+05 1.58E+06 2.16E+06 1.65E+06 1.24E+06 1.73E+06 1.58E+06 1.75E+06 1.04E+06 1.69E+06 1.17E+06 1.41E+06 1.97E+06 1.12E+06 L-Citrulline 1.82E+06 1.94E+06 1.55E+06 1.51E+06 1.41E+06 1.32E+06 1.37E+06 1.20E+06 1.35E+06 1.35E+06 1.65E+06 1.51E+06 6.14E+05 1.38E+06 1.20E+06 1.32E+06 1.35E+06 1.04E+06 1.18E+06 1.41E+06 8.83E+05 1.27E+06 1.33E+06 1.24E+06 1.03E+06 1.23E+06 1.00E+06 1.33E+06 1.33E+06 1.53E+06 1.49E+06 1.56E+06 1.66E+06 1.49E+06 6.55E+05 1.51E+06 1.01E+06 1.12E+06 1.29E+06 1.30E+06 1.40E+06 3.48E+06 1.62E+06 1.66E+06 1.21E+06 1.98E+06 1.62E+06 1.86E+06 1.34E+06 1.84E+06 8.86E+05 1.15E+06 1.14E+06 1.28E+06 1.41E+06 5.98E+05 8.21E+05 4.64E+05 Putrescine 6.43E+04 5.39E+04 5.82E+04 4.50E+04 4.63E+04 5.20E+04 3.67E+04 3.26E+04 4.58E+04 2.02E+04 1.65E+04 1.86E+04 6.76E+03 2.53E+04 2.50E+04 1.63E+04 1.90E+04 2.84E+04 2.11E+04 1.68E+04 7.06E+03 1.27E+04 1.66E+04 1.78E+04 1.54E+04 2.49E+04 1.52E+04 2.58E+04 1.36E+04 1.13E+04 1.29E+04 1.36E+04 6.22E+03 2.00E+04 1.54E+04 2.89E+04 1.57E+04 2.04E+04 1.52E+04 9.40E+03 1.32E+04 5.37E+03 1.56E+04 2.77E+04 1.42E+04 2.06E+04 2.19E+04 1.67E+04 1.74E+04 1.41E+04 4.33E+03 4.08E+03 6.24E+03 1.99E+04 1.83E+04 5.63E+03 1.78E+04 2.37E+04 Spermidine 2.22E+07 1.95E+07 2.00E+07 1.82E+07 1.36E+07 1.55E+07 1.37E+07 1.51E+07 1.41E+07 1.02E+06 1.55E+06 1.65E+06 3.02E+05 1.86E+06 1.54E+06 9.78E+05 1.38E+06 1.29E+06 1.83E+06 2.22E+06 7.41E+05 1.34E+06 1.43E+06 1.65E+06 1.03E+06 1.81E+06 1.49E+06 1.43E+06 1.25E+06 1.05E+06 9.15E+05 1.51E+06 6.73E+05 8.79E+05 1.17E+06 2.05E+06 7.92E+05 8.86E+05 1.32E+06 1.19E+06 1.36E+06 1.14E+06 1.25E+06 2.13E+06 9.04E+05 9.59E+05 1.95E+06 1.59E+06 1.09E+06 1.40E+06 1.08E+06 1.07E+06 6.11E+05 1.15E+06 9.57E+05 9.13E+05 1.34E+06 7.22E+05 Spermine 1.11E+06 9.88E+05 1.02E+06 1.01E+06 6.62E+05 7.33E+05 7.47E+05 8.79E+05 6.27E+05 1.31E+05 2.56E+05 1.59E+05 4.68E+04 1.50E+05 1.31E+05 1.14E+05 1.58E+05 1.56E+05 2.77E+05 2.52E+05 1.22E+05 1.83E+05 3.08E+05 1.66E+05 1.36E+05 2.65E+05 2.77E+05 1.02E+05 1.34E+05 1.74E+05 9.53E+04 2.16E+05 1.46E+05 9.21E+04 1.49E+05 1.21E+05 9.20E+04 1.28E+05 2.39E+05 1.96E+05 1.74E+05 1.98E+05 1.59E+05 1.58E+05 1.23E+05 1.22E+05 2.47E+05 1.71E+05 2.02E+05 5.59E+05 1.22E+05 1.39E+05 1.29E+05 1.23E+05 1.24E+05 1.51E+05 1.60E+05 1.11E+05 D-Glucosamine 6.14E+04 6.10E+04 3.88E+04 5.37E+04 5.53E+04 4.58E+04 2.86E+04 4.03E+04 4.77E+04 4.12E+04 3.31E+04 3.54E+04 2.66E+04 2.30E+04 2.88E+04 3.00E+04 2.71E+04 3.08E+04 4.90E+04 3.17E+04 4.72E+04 3.90E+04 2.85E+04 4.36E+04 3.76E+04 2.78E+04 2.31E+04 3.56E+04 3.81E+04 3.05E+04 2.80E+04 4.68E+04 2.90E+04 3.04E+04 2.23E+04 2.72E+04 2.45E+04 1.68E+04 2.56E+04 2.67E+04 3.41E+04 3.34E+04 2.51E+04 3.53E+04 2.31E+04 2.36E+04 3.03E+04 2.42E+04 4.01E+04 3.24E+04 3.98E+04 3.46E+04 2.47E+04 2.37E+04 2.93E+04 2.76E+04 1.65E+04 2.16E+04 Carnosine 4.63E+05 6.09E+05 4.31E+05 4.36E+05 3.20E+05 3.40E+05 3.06E+05 3.92E+05 3.91E+05 3.03E+05 2.80E+05 3.32E+05 1.30E+05 2.71E+05 2.47E+05 3.27E+05 3.26E+05 3.19E+05 2.88E+05 3.15E+05 3.17E+05 3.45E+05 2.75E+05 3.37E+05 3.18E+05 3.45E+05 2.03E+05 2.30E+05 2.48E+05 2.07E+05 2.61E+05 4.45E+05 3.00E+05 2.01E+05 3.21E+05 2.99E+05 3.08E+05 2.67E+05 2.42E+05 2.69E+05 2.86E+05 3.00E+05 2.93E+05 2.75E+05 4.04E+05 3.19E+05 3.61E+05 2.82E+05 2.88E+05 3.18E+05 3.14E+05 3.30E+05 2.86E+05 2.56E+05 3.22E+05 2.56E+05 2.99E+05 2.77E+05 5-Guanidino-2-oxopentanoate 2.37E+05 3.00E+05 1.90E+05 2.19E+05 1.80E+05 1.91E+05 1.43E+05 1.36E+05 1.10E+05 1.59E+05 1.77E+05 1.04E+05 3.12E+04 1.03E+05 1.34E+05 1.27E+05 1.28E+05 1.32E+05 1.44E+05 1.58E+05 7.90E+04 8.55E+04 1.80E+05 8.31E+04 1.04E+05 1.33E+05 7.92E+04 3.59E+04 1.68E+05 1.62E+05 1.05E+05 1.17E+05 1.45E+05 7.91E+04 8.36E+04 8.65E+04 6.47E+04 1.37E+05 1.96E+05 1.56E+05 1.42E+05 2.10E+05 1.70E+05 1.12E+05 1.30E+05 1.17E+05 1.50E+05 9.69E+04 2.15E+05 1.81E+05 1.08E+05 1.42E+05 1.19E+05 1.11E+05 1.00E+05 1.35E+05 1.15E+05 1.21E+05 Creatine 5.62E+07 5.93E+07 4.39E+07 3.18E+07 5.72E+07 4.30E+07 3.77E+07 3.90E+07 4.07E+07 5.03E+07 5.79E+07 4.34E+07 2.79E+07 4.69E+07 3.91E+07 4.46E+07 3.88E+07 4.37E+07 7.33E+07 5.30E+07 3.70E+07 4.25E+07 3.67E+07 3.72E+07 4.13E+07 4.36E+07 5.91E+07 4.80E+07 5.25E+07 5.83E+07 5.28E+07 3.59E+07 4.04E+07 3.25E+07 7.49E+07 5.44E+07 3.90E+07 3.65E+07 6.46E+07 6.45E+07 3.44E+07 4.79E+07 4.70E+07 5.23E+07 4.59E+07 5.13E+07 4.11E+07 6.04E+07 5.55E+07 4.06E+07 5.48E+07 3.50E+07 3.53E+07 5.34E+07 4.74E+07 7.00E+07 6.28E+07 7.74E+07 Creatinine 1.88E+06 1.90E+06 2.01E+06 1.53E+06 1.73E+06 1.44E+06 1.39E+06 1.30E+06 1.80E+06 1.89E+06 1.86E+06 1.25E+06 1.05E+06 1.63E+06 1.61E+06 1.54E+06 1.52E+06 1.90E+06 1.65E+06 1.19E+06 1.26E+06 1.64E+06 1.63E+06 2.28E+06 1.16E+06 1.17E+06 1.54E+06 1.34E+06 2.34E+06 1.67E+06 1.73E+06 1.48E+06 1.89E+06 1.70E+06 2.15E+06 1.18E+06 1.35E+06 1.51E+06 1.66E+06 1.75E+06 1.88E+06 3.33E+06 2.66E+06 1.72E+06 1.53E+06 1.74E+06 2.01E+06 1.59E+06 1.90E+06 1.37E+06 1.83E+06 1.66E+06 1.60E+06 1.68E+06 1.92E+06 1.62E+06 1.91E+06 1.83E+06 4-Acetamidobutanoate 1.76E+05 2.17E+05 1.97E+05 2.36E+05 2.51E+05 1.62E+05 2.13E+05 1.63E+05 1.72E+05 1.96E+05 1.52E+05 1.47E+05 7.68E+04 2.50E+05 2.02E+05 1.89E+05 2.08E+05 1.79E+05 1.61E+05 1.42E+05 1.22E+05 1.68E+05 1.53E+05 1.96E+05 1.77E+05 2.32E+05 1.43E+05 1.27E+05 1.92E+05 2.16E+05 1.99E+05 1.57E+05 1.50E+05 1.70E+05 1.27E+05 1.75E+05 1.99E+05 2.20E+05 1.71E+05 1.70E+05 1.58E+05 2.57E+05 1.88E+05 1.52E+05 1.73E+05 1.79E+05 2.07E+05 1.72E+05 2.25E+05 1.71E+05 1.31E+05 1.72E+05 1.67E+05 2.02E+05 1.91E+05 1.85E+05 2.03E+05 1.56E+05 N-Acetylornithine 2.21E+06 2.10E+06 2.16E+06 2.05E+06 2.86E+06 3.18E+06 2.75E+06 2.55E+06 2.58E+06 1.75E+06 1.77E+06 1.51E+06 4.97E+05 2.41E+06 1.82E+06 2.03E+06 1.67E+06 1.76E+06 1.45E+06 1.69E+06 8.88E+05 1.74E+06 1.27E+06 2.44E+06 1.56E+06 2.32E+06 1.56E+06 1.02E+06 1.60E+06 1.41E+06 1.13E+06 1.21E+06 9.94E+05 2.05E+06 7.74E+05 2.49E+06 1.91E+06 2.17E+06 1.14E+06 1.86E+06 1.56E+06 2.52E+06 1.79E+06 2.27E+06 1.90E+06 1.94E+06 2.22E+06 1.80E+06 1.55E+06 2.05E+06 8.53E+05 1.53E+06 1.20E+06 2.20E+06 1.92E+06 1.44E+06 1.83E+06 1.05E+06 Guanidinoacetate 2.48E+05 2.28E+05 1.47E+05 1.31E+05 1.26E+05 1.46E+05 9.95E+04 8.16E+04 7.00E+04 1.15E+05 1.00E+05 9.06E+04 3.70E+04 8.09E+04 1.09E+05 9.84E+04 8.93E+04 1.12E+05 1.03E+05 1.27E+05 6.66E+04 9.43E+04 9.50E+04 1.73E+05 7.09E+04 1.03E+05 6.71E+04 1.54E+05 1.52E+05 1.66E+05 1.37E+05 1.03E+05 1.24E+05 1.08E+05 8.59E+04 1.31E+05 8.45E+04 8.57E+04 1.45E+05 8.35E+04 7.98E+04 1.21E+05 1.19E+05 2.42E+05 1.09E+05 6.28E+04 1.18E+05 1.60E+05 1.44E+05 1.20E+05 8.94E+04 9.81E+04 8.00E+04 1.03E+05 6.49E+04 8.45E+04 1.02E+05 7.76E+04 trans-4-Hydroxy-L-proline 8.58E+05 8.64E+05 6.47E+05 8.93E+05 7.71E+05 4.98E+05 6.56E+05 4.74E+05 5.89E+05 8.66E+05 7.55E+05 7.08E+05 3.05E+05 7.25E+05 6.03E+05 5.76E+05 4.35E+05 5.36E+05 5.45E+05 5.99E+05 4.71E+05 6.47E+05 6.53E+05 6.39E+05 5.38E+05 5.07E+05 3.27E+05 2.96E+05 6.73E+05 6.75E+05 6.49E+05 8.65E+05 7.87E+05 3.93E+05 2.80E+05 5.49E+05 6.75E+05 6.21E+05 9.28E+05 3.09E+05 8.15E+05 1.35E+06 8.70E+05 6.81E+05 5.68E+05 5.33E+05 7.34E+05 4.72E+05 8.63E+05 8.80E+05 5.77E+05 7.63E+05 7.08E+05 4.78E+05 3.48E+05 5.26E+05 6.12E+05 3.66E+05 Pantothenol 1.00E+06 8.86E+05 7.50E+05 5.55E+05 1.35E+06 9.31E+05 6.24E+05 6.04E+05 6.75E+05 5.33E+05 5.48E+05 6.21E+05 2.62E+05 8.06E+05 5.65E+05 4.14E+05 4.51E+05 3.84E+05 6.34E+05 4.66E+05 4.31E+05 4.49E+05 4.12E+05 8.77E+05 7.31E+05 4.58E+05 4.65E+05 6.04E+05 5.70E+05 4.33E+05 4.61E+05 3.88E+05 3.90E+05 6.90E+05 1.77E+06 7.63E+05 5.69E+05 3.66E+05 4.94E+05 6.42E+05 3.97E+05 5.78E+05 4.38E+05 7.16E+05 5.42E+05 6.75E+05 5.79E+05 3.78E+05 6.45E+05 4.53E+05 6.05E+05 3.76E+05 2.96E+05 6.24E+05 6.16E+05 8.95E+05 5.22E+05 1.08E+06 5-6-Dihydrouracil 3.14E+05 5.65E+05 2.36E+05 1.96E+05 2.01E+05 1.87E+05 7.31E+04 1.52E+05 1.10E+05 1.33E+05 1.72E+05 1.78E+05 5.30E+04 6.15E+04 7.32E+04 6.77E+04 6.27E+04 1.10E+05 1.33E+05 9.98E+04 7.14E+04 1.02E+05 8.90E+04 1.45E+05 1.44E+05 1.05E+05 1.14E+05 2.21E+05 1.21E+05 1.39E+05 1.98E+05 2.30E+05 1.74E+05 1.49E+05 6.85E+05 2.83E+05 1.20E+05 1.26E+05 1.72E+05 2.48E+05 1.46E+05 2.50E+05 1.87E+05 2.44E+05 8.10E+04 1.72E+05 1.16E+05 1.25E+05 1.42E+05 1.62E+05 2.72E+05 1.13E+05 9.99E+04 1.02E+05 9.75E+04 2.19E+05 2.04E+05 5.45E+05 Pantetheine 4.98E+04 2.37E+04 5.14E+04 1.97E+04 4.44E+04 3.94E+04 1.13E+04 3.33E+04 2.26E+04 7.37E+04 5.13E+04 5.08E+04 1.89E+04 5.89E+04 5.20E+04 2.80E+04 5.11E+04 3.96E+04 4.56E+04 4.78E+04 3.51E+04 3.81E+04 3.86E+04 6.17E+04 4.04E+04 5.77E+03 3.68E+04 3.26E+04 5.41E+04 5.65E+04 6.59E+04 4.42E+04 3.73E+04 5.02E+04 5.08E+04 4.77E+04 3.25E+04 2.01E+04 5.01E+04 6.35E+04 4.49E+04 6.33E+04 3.26E+04 5.91E+04 4.14E+04 4.31E+04 3.81E+04 2.06E+04 5.96E+04 6.32E+04 6.52E+04 5.15E+04 3.35E+04 4.92E+04 2.23E+04 7.27E+04 4.47E+04 3.06E+04 Pantetheine 4--phosphate 6.65E+04 7.58E+04 6.06E+04 5.61E+04 5.43E+04 6.72E+04 2.21E+04 5.02E+04 6.37E+04 4.12E+04 3.18E+04 5.35E+04 1.57E+04 3.50E+04 5.08E+04 3.37E+04 3.56E+04 2.19E+04 5.13E+04 3.81E+04 3.44E+04 3.34E+04 4.43E+04 5.24E+04 3.89E+04 2.07E+04 3.52E+04 1.84E+04 4.57E+04 1.89E+04 5.01E+04 8.86E+04 2.97E+04 3.67E+04 2.67E+04 1.43E+04 4.72E+04 2.22E+04 3.17E+04 2.36E+04 5.21E+04 3.12E+04 2.80E+04 2.05E+04 3.33E+04 4.99E+04 4.89E+04 1.64E+04 3.93E+04 3.39E+04 5.96E+04 3.84E+04 3.43E+04 3.71E+04 3.00E+04 4.50E+04 3.21E+04 3.26E+04 Taurine 4.95E+06 4.28E+06 4.62E+06 2.44E+06 4.95E+06 4.91E+06 3.63E+06 4.40E+06 3.34E+06 3.25E+06 3.38E+06 3.09E+06 1.46E+06 3.02E+06 2.57E+06 3.73E+06 3.40E+06 3.27E+06 3.23E+06 2.30E+06 2.29E+06 3.08E+06 2.29E+06 2.31E+06 2.04E+06 2.21E+06 3.34E+06 2.42E+06 2.73E+06 2.17E+06 2.53E+06 1.60E+06 2.40E+06 2.69E+06 3.85E+06 3.07E+06 2.89E+06 3.18E+06 2.64E+06 2.71E+06 2.10E+06 1.82E+06 1.82E+06 2.90E+06 2.77E+06 2.82E+06 3.06E+06 2.54E+06 2.49E+06 1.50E+06 1.96E+06 2.07E+06 1.42E+06 2.69E+06 2.65E+06 2.04E+06 3.33E+06 3.28E+06 L-Methionine S-oxide 4.29E+05 5.13E+05 5.86E+05 5.00E+05 4.07E+05 5.16E+05 7.43E+05 4.58E+05 4.25E+05 4.26E+05 6.13E+05 5.07E+05 4.74E+05 4.08E+05 4.71E+05 4.90E+05 5.05E+05 4.94E+05 3.92E+05 5.75E+05 3.96E+05 4.44E+05 4.28E+05 3.73E+05 4.97E+05 6.69E+05 4.08E+05 5.71E+05 5.86E+05 7.53E+05 4.96E+05 4.75E+05 5.09E+05 4.35E+05 3.56E+05 5.03E+05 4.53E+05 5.37E+05 5.15E+05 5.39E+05 4.54E+05 9.06E+05 9.38E+05 4.73E+05 4.24E+05 4.89E+05 4.55E+05 5.19E+05 6.17E+05 3.81E+05 4.49E+05 4.34E+05 5.95E+05 4.06E+05 4.91E+05 4.40E+05 4.80E+05 3.95E+05 5-Hydroxyindoleacetate 4.57E+05 7.22E+05 4.23E+05 4.04E+05 5.38E+05 4.65E+05 2.96E+05 3.02E+05 3.66E+05 3.22E+05 1.26E+05 3.39E+05 1.06E+05 2.48E+05 3.26E+05 3.05E+05 1.78E+05 3.29E+05 2.39E+05 1.42E+05 2.38E+05 2.99E+05 2.71E+05 2.24E+05 2.77E+05 1.77E+05 2.41E+05 2.86E+05 2.45E+05 1.65E+05 1.81E+05 4.51E+05 2.28E+05 2.85E+05 2.59E+05 4.09E+05 2.97E+05 3.15E+05 7.55E+04 2.21E+05 3.10E+05 3.88E+05 2.39E+05 3.62E+05 2.69E+05 2.84E+05 3.44E+05 2.26E+05 2.44E+05 3.04E+05 3.86E+05 3.38E+05 2.52E+05 2.92E+05 2.68E+05 3.06E+05 2.88E+05 3.16E+05 Indole 1.02E+06 8.55E+05 1.02E+06 5.29E+05 7.49E+05 7.89E+05 3.11E+05 4.77E+05 6.71E+05 1.29E+06 1.59E+06 9.32E+05 9.41E+05 8.22E+05 1.24E+06 7.43E+05 1.05E+06 7.38E+05 6.55E+05 6.45E+05 6.53E+05 6.29E+05 6.34E+05 7.20E+05 7.25E+05 3.98E+05 5.65E+05 9.11E+05 1.47E+06 7.55E+05 1.65E+06 9.95E+05 1.13E+06 7.24E+05 5.18E+05 1.03E+06 9.61E+05 5.48E+05 9.96E+05 1.00E+06 1.02E+06 8.61E+05 6.99E+05 1.19E+06 7.33E+05 7.61E+05 5.65E+05 6.23E+05 8.35E+05 9.37E+05 1.48E+06 1.01E+06 6.05E+05 7.54E+05 4.56E+05 7.23E+05 5.42E+05 4.15E+05 Indolepyruvate 2.90E+05 3.71E+05 2.47E+05 2.45E+05 4.48E+05 2.20E+05 1.51E+05 2.54E+05 2.03E+05 2.77E+05 5.22E+03 2.88E+05 0.00E+00 3.87E+04 7.91E+04 1.87E+05 0.00E+00 1.44E+05 3.28E+05 1.57E+05 1.81E+05 2.86E+05 1.79E+05 1.21E+05 6.91E+04 8.03E+04 6.77E+04 1.09E+05 2.60E+05 1.46E+05 1.94E+04 3.81E+05 4.27E+04 1.57E+05 1.58E+04 5.28E+05 1.85E+05 1.72E+05 0.00E+00 1.44E+05 2.99E+05 2.51E+05 1.73E+05 2.91E+05 1.86E+05 2.23E+05 1.93E+05 1.47E+05 2.20E+05 3.36E+05 1.13E+05 4.13E+05 3.04E+05 2.19E+05 1.71E+05 5.85E+04 5.40E+04 1.67E+04 Indoxyl 3.22E+05 9.08E+05 6.14E+05 5.87E+05 5.65E+05 1.15E+06 7.54E+05 1.88E+06 2.13E+06 5.00E+05 6.63E+05 2.98E+06 6.43E+05 6.54E+05 5.50E+05 8.34E+05 1.36E+06 1.96E+06 3.50E+05 8.78E+05 1.40E+06 1.13E+06 1.48E+06 4.03E+05 8.03E+05 6.47E+05 7.78E+05 1.98E+06 2.26E+05 1.48E+06 3.32E+06 2.57E+06 1.78E+06 7.84E+05 8.20E+05 2.24E+06 1.03E+06 1.48E+06 1.89E+06 1.74E+06 3.63E+06 1.65E+06 1.74E+06 1.72E+06 9.51E+05 1.54E+06 1.28E+06 1.29E+06 1.19E+06 1.96E+06 1.36E+06 2.30E+06 1.94E+06 9.07E+05 9.15E+05 6.75E+05 8.62E+05 1.06E+06 kynurenine 2.61E+05 2.67E+05 1.94E+05 1.82E+05 1.84E+05 1.24E+05 1.63E+05 1.56E+05 1.65E+05 2.62E+05 1.65E+05 1.95E+05 5.35E+04 9.08E+04 1.31E+05 1.20E+05 8.46E+04 9.04E+04 2.10E+05 3.01E+05 1.65E+05 2.30E+05 1.95E+05 2.03E+05 9.86E+04 1.47E+05 1.17E+05 1.52E+05 1.53E+05 2.21E+05 2.61E+05 2.80E+05 3.07E+05 1.47E+05 1.43E+05 2.05E+05 1.36E+05 2.05E+05 2.10E+05 2.66E+05 2.83E+05 5.34E+05 3.37E+05 2.14E+05 1.36E+05 1.22E+05 1.89E+05 1.95E+05 3.52E+05 3.02E+05 2.94E+05 3.21E+05 3.54E+05 1.26E+05 2.06E+05 2.05E+05 2.07E+05 1.82E+05 N-formyl kynurenine 3.15E+05 4.87E+05 2.60E+05 2.95E+05 3.49E+05 3.64E+05 1.22E+05 3.33E+05 2.45E+05 3.30E+05 6.07E+04 3.20E+05 1.20E+04 3.84E+05 3.02E+05 3.66E+05 3.76E+04 2.54E+05 6.11E+05 2.49E+05 4.93E+05 2.49E+05 2.97E+05 3.26E+05 3.17E+05 2.50E+05 2.54E+05 3.64E+05 4.63E+05 2.64E+05 4.03E+04 3.68E+05 9.56E+04 3.62E+05 3.81E+05 2.57E+05 3.07E+05 1.91E+05 6.29E+04 4.05E+05 2.98E+05 3.06E+05 2.85E+05 3.84E+05 3.57E+05 3.31E+05 3.12E+05 2.55E+05 4.89E+05 4.33E+05 5.26E+05 4.86E+05 4.09E+05 3.14E+05 5.49E+05 4.79E+05 3.55E+05 2.94E+05 Anthranilate 2.89E+06 3.62E+06 3.69E+06 2.64E+06 3.30E+06 3.73E+06 2.61E+06 2.67E+06 3.19E+06 3.08E+06 3.03E+06 2.15E+06 1.60E+06 2.38E+06 2.69E+06 2.76E+06 2.45E+06 2.72E+06 1.50E+06 1.59E+06 1.88E+06 2.41E+06 1.77E+06 2.20E+06 1.11E+06 1.02E+06 1.89E+06 9.57E+05 3.91E+06 2.63E+06 3.38E+06 2.80E+06 2.26E+06 2.73E+06 1.44E+05 1.45E+06 1.62E+06 2.60E+06 2.41E+06 2.13E+06 2.22E+06 3.97E+06 3.41E+06 1.51E+06 2.39E+06 2.03E+06 3.16E+06 1.07E+06 3.26E+06 2.21E+06 1.52E+06 1.88E+06 2.23E+06 3.13E+06 2.69E+06 1.32E+06 1.34E+06 1.92E+05 g-Oxalo-crotonate 7.67E+06 1.00E+07 7.02E+06 5.51E+06 8.27E+06 7.03E+06 3.79E+06 3.60E+06 3.17E+06 1.05E+07 6.55E+06 7.47E+06 1.29E+06 5.78E+06 2.34E+06 2.57E+06 1.01E+06 4.82E+05 7.78E+06 3.70E+06 2.02E+06 4.30E+06 2.40E+06 3.75E+06 1.64E+06 9.17E+05 3.27E+05 1.36E+05 9.14E+06 1.14E+07 7.74E+06 2.17E+06 3.47E+06 5.86E+06 7.36E+06 2.79E+06 3.79E+06 8.54E+05 9.94E+06 6.41E+06 5.87E+06 4.23E+06 8.30E+05 6.95E+06 1.56E+06 6.63E+05 1.04E+06 8.48E+04 6.24E+06 6.34E+06 2.84E+06 2.67E+06 4.47E+05 1.90E+06 1.04E+06 4.63E+05 1.59E+04 5.26E+05 Hydroxyindole-acetylglycine 3.92E+04 5.53E+04 5.16E+04 1.60E+04 3.74E+04 3.78E+04 3.87E+04 3.11E+04 2.27E+04 3.22E+04 0.00E+00 2.66E+04 0.00E+00 2.27E+04 1.43E+04 2.61E+04 0.00E+00 5.33E+04 3.66E+04 1.63E+04 2.92E+04 3.45E+04 1.67E+04 7.01E+03 3.18E+04 6.65E+03 1.36E+04 2.28E+04 2.94E+04 5.52E+04 1.88E+03 4.74E+04 0.00E+00 2.62E+04 2.99E+04 1.45E+04 2.11E+04 6.12E+04 4.22E+03 3.37E+04 8.91E+04 9.15E+04 8.09E+04 2.35E+04 3.41E+04 1.83E+04 2.67E+04 1.73E+04 4.72E+04 3.73E+04 2.29E+04 3.54E+04 1.96E+04 5.93E+04 3.47E+04 2.62E+04 2.65E+04 1.10E+04 L-Adrenaline 3.10E+05 2.73E+05 2.22E+05 2.90E+05 2.97E+05 3.68E+05 1.53E+05 2.92E+05 3.52E+05 2.28E+05 2.05E+05 2.75E+05 3.71E+05 2.33E+05 3.73E+05 3.04E+05 2.56E+05 2.87E+05 3.25E+05 1.87E+05 4.15E+05 2.51E+05 3.27E+05 3.08E+05 3.13E+05 2.36E+05 3.02E+05 2.69E+05 2.02E+05 1.36E+05 1.82E+05 3.03E+05 2.33E+05 3.01E+05 3.72E+05 3.20E+05 2.84E+05 1.89E+05 1.95E+05 2.22E+05 3.36E+05 2.62E+05 2.24E+05 4.01E+05 3.79E+05 2.73E+05 3.87E+05 2.23E+05 2.65E+05 2.78E+05 3.07E+05 2.94E+05 2.81E+05 3.37E+05 4.65E+05 4.56E+05 3.15E+05 4.19E+05 Dopamine 4.27E+05 4.84E+05 3.90E+05 3.83E+05 3.91E+05 5.13E+05 3.26E+05 4.42E+05 4.78E+05 3.88E+05 2.86E+05 3.39E+05 1.60E+05 3.74E+05 4.64E+05 3.71E+05 2.41E+05 3.59E+05 3.96E+05 3.57E+05 3.75E+05 3.47E+05 4.03E+05 4.07E+05 4.04E+05 3.36E+05 3.89E+05 4.05E+05 3.03E+05 2.80E+05 2.66E+05 4.33E+05 2.77E+05 4.01E+05 4.27E+05 3.97E+05 4.27E+05 3.48E+05 2.34E+05 3.42E+05 4.33E+05 3.38E+05 3.19E+05 5.28E+05 4.10E+05 3.30E+05 4.46E+05 3.70E+05 3.61E+05 3.53E+05 4.40E+05 3.87E+05 3.44E+05 4.56E+05 4.47E+05 4.82E+05 4.21E+05 4.15E+05 Ectoine 9.94E+05 1.18E+06 1.10E+06 9.13E+05 9.23E+05 9.80E+05 1.04E+06 7.01E+05 6.58E+05 9.76E+05 7.54E+05 5.72E+05 3.37E+05 7.77E+05 7.59E+05 7.23E+05 6.12E+05 8.53E+05 4.95E+05 7.08E+05 6.45E+05 6.19E+05 4.88E+05 5.77E+05 2.73E+05 5.44E+05 4.02E+05 3.36E+05 1.01E+06 1.04E+06 6.52E+05 9.35E+05 6.49E+05 5.52E+05 1.51E+05 7.67E+05 5.33E+05 1.05E+06 6.85E+05 8.37E+05 7.09E+05 1.56E+06 1.36E+06 6.83E+05 6.11E+05 5.85E+05 6.37E+05 5.29E+05 1.06E+06 6.25E+05 4.72E+05 8.62E+05 6.98E+05 6.23E+05 4.97E+05 5.07E+05 6.22E+05 2.30E+05 N-Methylethanolamine phosphate 2.47E+05 2.49E+05 3.65E+05 1.82E+05 1.81E+05 2.33E+05 1.50E+05 1.87E+05 1.95E+05 2.56E+05 5.31E+05 3.11E+05 6.94E+04 1.96E+05 2.12E+05 1.39E+05 1.63E+05 2.05E+05 4.42E+05 2.42E+05 1.53E+05 2.89E+05 3.23E+05 1.02E+05 2.06E+05 2.22E+05 1.38E+05 2.07E+05 3.86E+05 5.75E+05 4.07E+05 3.94E+05 2.73E+05 1.34E+05 9.37E+04 2.36E+05 2.09E+05 2.58E+05 5.68E+05 6.62E+05 2.18E+05 4.13E+05 5.26E+05 2.80E+05 1.98E+05 2.82E+05 4.80E+05 4.33E+05 4.99E+05 2.41E+05 1.80E+05 4.91E+05 2.89E+05 2.23E+05 2.39E+05 1.56E+05 1.45E+05 7.15E+04 Sphingosine 1.31E+06 1.87E+06 7.99E+05 1.62E+06 2.24E+06 1.36E+06 1.09E+06 2.10E+06 1.75E+06 1.59E+06 8.96E+05 1.72E+06 1.27E+06 1.89E+06 2.18E+06 1.51E+06 1.77E+06 1.84E+06 1.64E+06 8.26E+05 1.81E+06 1.39E+06 6.74E+05 1.48E+06 2.26E+06 5.70E+05 1.85E+06 2.95E+06 1.60E+06 1.00E+06 1.71E+06 2.18E+06 1.49E+06 1.97E+06 9.03E+05 1.72E+06 1.42E+06 8.74E+05 1.00E+06 6.59E+05 1.54E+06 1.44E+06 9.09E+05 2.12E+06 1.21E+06 1.70E+06 2.43E+06 1.64E+06 1.54E+06 1.83E+06 2.75E+06 1.87E+06 1.42E+06 1.62E+06 1.89E+06 1.50E+06 7.82E+05 1.43E+06 Acetylcholine 5.13E+06 5.95E+06 5.51E+06 4.10E+06 3.57E+06 3.72E+06 3.19E+06 2.83E+06 2.93E+06 2.56E+06 2.69E+06 2.49E+06 1.53E+06 1.55E+06 1.48E+06 1.34E+06 1.31E+06 1.39E+06 2.59E+06 3.14E+06 2.28E+06 2.46E+06 3.13E+06 2.08E+06 1.45E+06 1.93E+06 3.46E+06 4.70E+06 4.98E+06 3.79E+06 1.92E+06 2.71E+06 2.17E+06 1.03E+06 1.12E+06 2.46E+06 1.15E+06 1.31E+06 2.22E+06 2.43E+06 2.08E+06 2.10E+06 2.19E+06 2.91E+06 1.08E+06 1.25E+06 1.63E+06 2.39E+06 2.14E+06 1.77E+06 2.02E+06 2.22E+06 1.93E+06 1.51E+06 1.43E+06 1.29E+06 1.55E+06 1.06E+06 L-Carnitine 2.32E+07 1.77E+07 1.88E+07 1.57E+07 2.12E+07 1.66E+07 1.73E+07 1.54E+07 1.34E+07 1.62E+07 1.43E+07 1.72E+07 8.54E+06 2.04E+07 1.74E+07 1.50E+07 1.23E+07 1.43E+07 1.72E+07 1.44E+07 1.38E+07 1.46E+07 1.34E+07 2.05E+07 1.43E+07 1.61E+07 1.79E+07 1.36E+07 1.21E+07 1.49E+07 1.45E+07 1.18E+07 1.26E+07 1.37E+07 7.62E+06 2.00E+07 1.42E+07 1.27E+07 1.59E+07 1.51E+07 1.36E+07 1.48E+07 1.57E+07 1.95E+07 2.03E+07 2.02E+07 1.73E+07 2.35E+07 1.89E+07 1.69E+07 1.23E+07 1.43E+07 1.25E+07 1.81E+07 1.62E+07 1.52E+07 2.04E+07 5.27E+06 acetyl-carnitine (acyl-C2) 1.30E+08 1.60E+08 1.16E+08 1.12E+08 1.35E+08 1.18E+08 1.14E+08 8.44E+07 8.08E+07 8.62E+07 1.13E+08 9.94E+07 4.24E+07 9.80E+07 7.98E+07 7.32E+07 6.57E+07 7.58E+07 8.69E+07 9.27E+07 6.88E+07 8.80E+07 8.58E+07 1.05E+08 7.93E+07 9.24E+07 7.46E+07 8.03E+07 6.91E+07 8.58E+07 6.31E+07 7.40E+07 7.84E+07 6.25E+07 1.16E+08 1.05E+08 7.19E+07 6.52E+07 7.49E+07 8.06E+07 7.99E+07 8.29E+07 7.78E+07 1.08E+08 8.40E+07 7.24E+07 8.01E+07 6.81E+07 8.01E+07 8.19E+07 6.87E+07 7.78E+07 6.11E+07 8.32E+07 7.37E+07 7.09E+07 8.55E+07 1.02E+08 propionyl-carnitine (acyl-C3) 2.89E+06 3.04E+06 1.91E+06 1.86E+06 1.88E+06 1.58E+06 1.89E+06 1.51E+06 1.16E+06 1.38E+06 1.26E+06 1.03E+06 3.78E+05 9.62E+05 7.61E+05 7.94E+05 5.90E+05 6.55E+05 8.76E+05 9.24E+05 7.25E+05 8.12E+05 5.81E+05 9.47E+05 6.98E+05 6.92E+05 5.97E+05 8.07E+05 7.98E+05 1.43E+06 7.30E+05 7.93E+05 7.92E+05 8.41E+05 1.14E+06 2.25E+06 8.36E+05 5.41E+05 1.10E+06 1.21E+06 1.02E+06 1.16E+06 1.07E+06 2.46E+06 9.47E+05 7.79E+05 7.89E+05 9.39E+05 1.03E+06 1.12E+06 4.97E+05 8.89E+05 5.56E+05 9.34E+05 1.04E+06 8.21E+05 7.45E+05 7.80E+05 butanoyl-l-carnitine (acyl-C4) 8.60E+05 5.76E+05 6.35E+05 4.39E+05 6.03E+05 5.53E+05 7.68E+05 5.30E+05 3.54E+05 4.97E+05 5.27E+05 3.62E+05 1.70E+05 4.31E+05 3.45E+05 4.49E+05 3.27E+05 4.63E+05 3.83E+05 3.19E+05 2.55E+05 2.76E+05 2.60E+05 8.19E+05 2.35E+05 2.50E+05 2.50E+05 3.26E+05 8.45E+05 5.59E+05 4.60E+05 3.13E+05 3.38E+05 5.42E+05 7.08E+05 7.32E+05 3.21E+05 4.96E+05 5.97E+05 6.80E+05 3.93E+05 5.30E+05 6.73E+05 8.84E+05 3.77E+05 3.04E+05 3.08E+05 6.02E+05 5.18E+05 3.24E+05 3.05E+05 3.33E+05 4.05E+05 4.96E+05 3.40E+05 3.87E+05 4.45E+05 3.72E+05 acyl-C4-OH (Hydroxybutyrylcarnitine) 5.23E+05 7.68E+05 3.73E+05 4.40E+05 4.86E+05 3.77E+05 3.75E+05 3.36E+05 2.71E+05 3.02E+05 3.38E+05 3.33E+05 1.22E+05 2.70E+05 2.04E+05 2.25E+05 1.77E+05 1.84E+05 3.05E+05 2.83E+05 2.04E+05 2.85E+05 2.78E+05 3.72E+05 2.28E+05 2.27E+05 2.26E+05 3.70E+05 2.07E+05 2.10E+05 2.30E+05 2.01E+05 2.39E+05 2.64E+05 8.64E+05 2.87E+05 2.04E+05 1.77E+05 2.53E+05 2.26E+05 1.68E+05 2.24E+05 1.97E+05 5.59E+05 2.07E+05 1.49E+05 2.11E+05 2.60E+05 1.66E+05 2.53E+05 1.89E+05 1.81E+05 1.63E+05 2.67E+05 3.01E+05 2.18E+05 2.02E+05 7.55E+05 acyl-C5:1 (Tiglylcarnitine) 2.66E+05 2.61E+05 3.16E+05 1.55E+05 2.04E+05 1.48E+05 1.57E+05 2.00E+05 1.01E+05 2.18E+05 1.64E+04 1.37E+05 2.02E+04 1.35E+05 1.67E+05 1.90E+05 1.78E+04 2.09E+05 2.01E+05 1.56E+05 1.20E+05 1.68E+05 1.61E+05 1.56E+05 1.10E+05 9.10E+04 9.86E+04 1.53E+05 2.64E+05 2.74E+05 3.14E+04 2.49E+05 7.19E+04 1.52E+05 1.66E+05 1.56E+05 1.71E+05 1.77E+05 4.50E+04 2.09E+05 1.91E+05 4.35E+05 3.34E+05 1.42E+05 2.07E+05 1.22E+05 1.88E+05 1.50E+05 3.04E+05 1.89E+05 1.57E+05 2.12E+05 1.93E+05 2.94E+05 2.58E+05 1.88E+05 1.98E+05 2.25E+05 acyl-C5-OH (hydroxyisovalerylcarnitine) 2.58E+05 3.05E+05 2.34E+05 2.34E+05 2.79E+05 2.10E+05 1.96E+05 1.77E+05 1.90E+05 2.44E+05 2.75E+05 2.45E+05 7.97E+04 1.52E+05 1.70E+05 1.93E+05 9.78E+04 9.31E+04 1.60E+05 1.98E+05 7.98E+04 2.07E+05 1.92E+05 2.83E+05 2.03E+05 1.69E+05 2.66E+05 2.63E+05 2.24E+05 1.77E+05 1.35E+05 1.89E+05 1.53E+05 2.02E+05 1.83E+05 2.92E+05 1.22E+05 1.60E+05 1.61E+05 1.80E+05 1.96E+05 1.92E+05 1.60E+05 2.85E+05 2.03E+05 1.51E+05 1.54E+05 2.49E+05 1.69E+05 1.60E+05 1.57E+05 2.02E+05 9.58E+04 1.41E+05 1.14E+05 1.35E+05 1.93E+05 1.04E+05 hexanoyl-L-carnitine (acyl-C6) 2.72E+05 2.19E+05 1.81E+05 1.40E+05 1.98E+05 1.87E+05 1.61E+05 1.40E+05 1.66E+05 7.39E+04 4.60E+04 7.33E+04 3.94E+04 9.32E+04 7.10E+04 7.61E+04 5.61E+04 7.49E+04 9.14E+04 5.29E+04 5.09E+04 4.80E+04 6.29E+04 1.73E+05 8.94E+04 7.54E+04 9.59E+04 1.24E+05 6.38E+04 8.24E+04 5.34E+04 6.80E+04 5.39E+04 1.22E+05 1.84E+05 1.57E+05 8.19E+04 6.20E+04 6.43E+04 8.49E+04 6.82E+04 7.67E+04 5.74E+04 1.93E+05 1.08E+05 8.30E+04 7.08E+04 1.23E+05 7.00E+04 7.19E+04 7.38E+04 6.71E+04 4.24E+04 1.06E+05 1.32E+05 9.29E+04 8.12E+04 2.99E+05 L-octanoylcarnitine (acyl-C8) 4.81E+05 3.49E+05 3.59E+05 2.99E+05 3.38E+05 2.92E+05 3.83E+05 3.79E+05 3.39E+05 5.16E+04 7.08E+04 6.11E+04 3.35E+04 7.32E+04 7.54E+04 5.06E+04 7.72E+04 4.77E+04 6.88E+04 7.95E+04 6.13E+04 6.55E+04 5.73E+04 7.78E+04 7.18E+04 4.74E+04 6.06E+04 1.26E+05 3.74E+04 4.62E+04 2.22E+04 5.59E+04 4.17E+04 6.38E+04 1.21E+05 1.05E+05 5.66E+04 5.66E+04 3.11E+04 5.14E+04 4.46E+04 6.26E+04 3.28E+04 9.83E+04 7.58E+04 7.20E+04 5.96E+04 1.11E+05 6.83E+04 6.29E+04 3.78E+04 2.73E+04 3.05E+04 5.63E+04 8.24E+04 7.23E+04 8.54E+04 1.47E+05 octenoyl-l-carnitine (acyl-C8:1) 9.50E+04 8.98E+04 6.78E+04 4.27E+04 5.01E+04 6.05E+04 6.58E+04 5.59E+04 4.08E+04 2.02E+04 5.87E+03 1.69E+04 0.00E+00 1.70E+04 1.31E+04 1.61E+04 7.83E+03 1.18E+04 1.92E+04 9.01E+03 1.17E+04 1.54E+04 1.79E+04 4.35E+04 6.91E+03 2.01E+04 1.88E+04 2.89E+04 1.09E+04 1.72E+04 5.40E+03 1.14E+04 6.48E+03 1.38E+04 3.32E+04 2.37E+04 1.10E+04 2.05E+04 6.51E+03 1.52E+04 2.22E+04 2.06E+04 1.68E+04 2.97E+04 2.31E+04 1.59E+04 9.32E+03 3.38E+04 2.16E+04 7.78E+03 2.56E+04 1.93E+04 3.03E+04 2.47E+04 1.60E+04 1.65E+04 2.67E+04 1.55E+04 O-Decenoyl-L-carnitine (acyl-C10:1) 3.30E+05 2.35E+05 2.45E+05 2.13E+05 2.42E+05 1.83E+05 2.06E+05 2.16E+05 1.88E+05 2.87E+04 4.21E+04 4.95E+04 1.93E+04 3.17E+04 4.66E+04 2.62E+04 4.78E+04 3.70E+04 4.61E+04 4.03E+04 3.29E+04 4.27E+04 6.53E+04 7.52E+04 3.25E+04 3.45E+04 3.76E+04 7.60E+04 2.32E+04 4.95E+04 2.92E+04 5.32E+04 2.36E+04 3.61E+04 6.27E+04 5.54E+04 3.82E+04 3.24E+04 3.54E+04 4.91E+04 3.37E+04 3.55E+04 8.13E+03 9.91E+04 4.60E+04 5.66E+04 5.17E+04 8.06E+04 2.76E+04 4.42E+04 3.81E+04 3.46E+04 3.26E+04 4.13E+04 4.73E+04 6.40E+04 6.38E+04 9.05E+04 O-dodecanoyl-carnitine (acyl-C12) 1.20E+05 1.15E+05 9.33E+04 5.28E+04 7.89E+04 8.14E+04 6.48E+04 9.69E+04 8.37E+04 6.00E+04 5.53E+04 4.35E+04 3.03E+04 3.95E+04 2.63E+04 4.19E+04 5.75E+04 4.10E+04 5.16E+04 3.09E+04 6.24E+04 4.00E+04 4.53E+04 5.88E+04 4.50E+04 2.78E+04 3.84E+04 1.01E+05 4.79E+04 2.86E+04 2.88E+04 4.21E+04 3.76E+04 3.64E+04 1.04E+05 8.79E+04 5.84E+04 3.53E+04 3.46E+04 3.29E+04 4.07E+04 3.15E+04 1.97E+04 6.88E+04 4.27E+04 2.50E+05 3.76E+04 7.08E+04 4.87E+04 4.27E+04 6.13E+04 5.33E+04 2.99E+04 3.73E+04 3.87E+04 5.00E+04 4.81E+04 1.20E+05 O-dodecenoyl-carnitine (acyl-C12:1) 5.72E+04 3.79E+04 1.73E+04 2.73E+04 3.85E+04 3.89E+04 1.16E+04 2.63E+04 4.02E+04 2.60E+04 4.58E+03 2.75E+04 9.63E+03 1.63E+04 2.60E+04 9.01E+03 1.77E+04 2.58E+04 2.95E+04 1.16E+04 7.16E+03 1.45E+04 2.23E+04 4.94E+04 2.27E+04 1.56E+04 1.15E+04 3.60E+04 1.74E+04 9.11E+03 2.05E+04 2.44E+04 1.42E+04 2.59E+04 3.00E+04 2.34E+04 3.89E+04 1.55E+04 1.80E+04 2.41E+04 2.79E+04 2.28E+04 1.13E+04 6.41E+04 1.81E+04 3.79E+04 4.16E+04 3.34E+04 1.61E+04 1.92E+04 1.71E+04 2.60E+04 1.72E+04 2.56E+04 2.18E+04 2.09E+04 3.52E+04 6.90E+04 O-tetradecanoyl-L-carnitine (acyl-C14) 3.35E+05 3.53E+05 1.69E+05 2.12E+05 1.88E+05 1.88E+05 1.04E+05 1.77E+05 2.17E+05 1.47E+05 9.27E+04 1.75E+05 8.09E+04 1.33E+05 1.54E+05 1.03E+05 1.18E+05 1.21E+05 1.06E+05 5.18E+04 1.15E+05 1.08E+05 8.13E+04 1.54E+05 1.42E+05 5.95E+04 1.22E+05 2.39E+05 7.48E+04 7.02E+04 1.04E+05 1.30E+05 1.27E+05 1.63E+05 1.67E+05 2.20E+05 9.40E+04 5.53E+04 7.77E+04 6.61E+04 1.01E+05 8.94E+04 8.16E+04 3.21E+05 1.07E+05 1.04E+05 1.55E+05 1.41E+05 9.14E+04 1.24E+05 1.60E+05 1.02E+05 7.73E+04 1.30E+05 1.06E+05 1.16E+05 8.74E+04 1.66E+05 Tetradecenoyl Carnitine (acyl-C14:1) 1.14E+05 9.84E+04 6.29E+04 7.59E+04 8.96E+04 6.32E+04 1.99E+04 8.45E+04 7.86E+04 4.28E+04 4.12E+04 6.85E+04 2.78E+04 6.82E+04 6.63E+04 3.64E+04 5.99E+04 3.89E+04 5.51E+04 2.41E+04 5.22E+04 4.69E+04 3.52E+04 9.96E+04 5.55E+04 2.41E+04 5.04E+04 1.15E+05 5.64E+04 3.51E+04 4.96E+04 3.47E+04 4.15E+04 1.07E+05 1.15E+05 8.07E+04 6.75E+04 2.59E+04 5.43E+04 2.41E+04 5.53E+04 4.59E+04 2.32E+04 1.15E+05 5.55E+04 6.07E+04 7.78E+04 6.50E+04 6.06E+04 9.07E+04 6.23E+04 4.59E+04 2.50E+04 7.81E+04 5.97E+04 7.28E+04 8.21E+04 1.50E+05 L-Palmitoylcarnitine (acyl-C16) 1.32E+06 1.13E+06 1.32E+06 1.03E+06 1.03E+06 1.14E+06 4.00E+05 9.44E+05 1.37E+06 6.68E+05 6.40E+05 1.01E+06 5.25E+05 8.61E+05 8.26E+05 6.99E+05 6.58E+05 6.79E+05 8.02E+05 2.53E+05 7.29E+05 8.61E+05 8.41E+05 7.65E+05 9.76E+05 3.38E+05 6.56E+05 1.27E+06 6.62E+05 4.66E+05 5.55E+05 1.04E+06 5.71E+05 6.43E+05 7.48E+05 1.23E+06 7.20E+05 4.14E+05 5.38E+05 3.47E+05 6.68E+05 5.80E+05 3.28E+05 1.09E+06 5.15E+05 5.01E+05 9.08E+05 7.30E+05 8.35E+05 6.37E+05 7.99E+05 6.89E+05 4.34E+05 7.50E+05 7.31E+05 6.96E+05 7.65E+05 7.53E+05 Hexadecenoyl-carnitine (acyl-C16:1) 1.74E+05 1.96E+05 1.22E+05 1.16E+05 1.63E+05 2.00E+05 3.71E+04 1.62E+05 1.89E+05 9.25E+04 7.38E+04 1.87E+05 5.71E+04 8.54E+04 9.83E+04 1.11E+05 8.79E+04 9.53E+04 7.07E+04 4.22E+04 6.40E+04 7.35E+04 9.00E+04 1.44E+05 7.74E+04 4.15E+04 8.29E+04 2.53E+05 6.45E+04 4.49E+04 7.44E+04 8.80E+04 6.99E+04 1.03E+05 1.11E+05 1.53E+05 9.00E+04 5.82E+04 8.73E+04 3.16E+04 6.75E+04 5.65E+04 3.54E+04 1.20E+05 7.48E+04 8.02E+04 8.53E+04 1.11E+05 8.83E+04 6.45E+04 1.44E+05 6.98E+04 3.43E+04 8.98E+04 1.17E+05 9.30E+04 8.16E+04 2.01E+05 O-octadecenoyl-L-carnitine (acyl-C18:1) 6.04E+05 3.93E+05 3.82E+05 3.78E+05 4.51E+05 4.48E+05 1.54E+05 3.53E+05 4.25E+05 2.63E+05 2.71E+05 3.67E+05 1.95E+05 4.18E+05 3.35E+05 2.67E+05 3.58E+05 3.08E+05 3.85E+05 1.50E+05 2.58E+05 3.13E+05 2.74E+05 4.59E+05 4.35E+05 1.49E+05 2.44E+05 4.74E+05 2.39E+05 1.43E+05 2.50E+05 4.06E+05 2.52E+05 2.74E+05 5.20E+05 4.67E+05 3.43E+05 2.01E+05 1.99E+05 1.51E+05 2.70E+05 1.95E+05 1.71E+05 3.97E+05 3.44E+05 4.01E+05 4.30E+05 2.70E+05 2.75E+05 3.97E+05 3.49E+05 2.99E+05 2.26E+05 3.60E+05 3.58E+05 4.41E+05 4.20E+05 5.22E+05 acyl-C18:2 (Linoleoyl-CoA) 4.02E+05 4.28E+05 3.91E+05 4.19E+05 3.33E+05 3.51E+05 1.80E+05 2.80E+05 3.15E+05 2.52E+05 2.78E+05 2.94E+05 1.10E+05 2.30E+05 2.11E+05 1.76E+05 2.09E+05 1.72E+05 2.88E+05 1.41E+05 1.48E+05 1.70E+05 1.58E+05 2.23E+05 1.91E+05 8.71E+04 1.63E+05 3.55E+05 1.89E+05 1.04E+05 2.24E+05 3.22E+05 2.10E+05 2.54E+05 1.74E+05 3.16E+05 1.44E+05 1.30E+05 1.83E+05 8.16E+04 1.38E+05 1.80E+05 1.18E+05 3.40E+05 1.95E+05 1.63E+05 2.38E+05 2.41E+05 2.50E+05 2.13E+05 2.86E+05 2.24E+05 1.01E+05 1.76E+05 1.45E+05 1.70E+05 1.92E+05 2.34E+05 acyl-C20:4 1.83E+05 1.70E+05 1.57E+05 1.24E+05 1.48E+05 1.14E+05 4.48E+04 1.27E+05 1.15E+05 8.48E+04 7.78E+04 8.06E+04 2.00E+04 7.54E+04 5.62E+04 5.83E+04 4.87E+04 4.48E+04 7.61E+04 3.82E+04 4.87E+04 6.04E+04 5.19E+04 4.96E+04 5.27E+04 2.62E+04 6.67E+04 1.81E+05 6.12E+04 4.23E+04 5.93E+04 7.40E+04 5.08E+04 8.10E+04 3.75E+04 8.63E+04 3.72E+04 3.66E+04 7.07E+04 2.46E+04 4.98E+04 5.98E+04 2.34E+04 9.78E+04 4.25E+04 3.87E+04 6.85E+04 7.12E+04 7.79E+04 6.73E+04 8.36E+04 5.39E+04 3.19E+04 4.64E+04 4.79E+04 5.97E+04 4.54E+04 5.23E+04 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name KEGG ID parent medRt L-alanine C00041 90.0549 0.66 L-arginine C00062 175.1189 0.62 L-asparagine C00152 133.0606 0.68 L-aspartate C00049 134.0446 0.67 L-glutamate C00025 148.0604 0.66 L-glutamine C00064 147.0763 0.65 L-histidine C00135 156.0768 0.60 L-leucine/isoleucine C00123 132.1017 0.68 L-lysine C00047 147.1127 0.59 L-methionine C00073 150.0583 0.68 L-phenylalanine C00079 166.0860 0.68 L-proline C00148 116.0704 0.68 L-serine C00065 106.0498 0.65 L-threonine C00188 120.0654 0.65 L-tryptophan C00078 205.0969 1.72 L-tyrosine C00082 182.0811 0.68 L-valine C00183 118.0860 0.68 L-cystine C00491 241.0298 0.66 Adenosine C00212 268.1035 0.89 Guanine C00242 152.0566 0.82 Cytidine C00475 244.0920 0.67 Cytosine C00380 112.0505 0.68 IMP C00130 349.0538 0.68 Inosine C00294 269.0871 0.68 Hypoxanthine C00262 137.0458 0.68 Xanthine C00385 153.0407 0.68 Allantoate C00499 177.0609 0.60 5-Hydroxyisourate C11821 185.0322 0.65 3',5'-Cyclic AMP C00575 330.0579 0.68 2',3'-Cyclic CMP C02354 306.0488 0.68 5-6-Dihydrothymine C00906 129.0658 0.67 Pyridoxamine 5'-phosphate C00647 249.0605 1.72 Nicotinamide C00153 123.0551 0.68 NADP+ C00006 744.0812 0.85 NAD+ C00003 664.1144 0.67 Phosphate C00009 98.9840 0.71 Glutathione disulfide C00127 613.1581 0.68 5-Oxoproline C01879 130.0498 0.67 S-Glutathionyl-L-cysteine C05526 427.0941 0.66 gamma-Glutamyl-gamma-aminobutyrate C15767 233.1127 0.68 L-Homocysteine C00155 136.0427 0.68 Dimethylglycine C01026 104.0704 0.69 S-Adenosyl-L-methionine C00019 399.1435 0.65 Ornithine C01602 133.0971 0.59 L-Citrulline C00327 176.1028 0.65 Putrescine C00134 89.1072 0.58 Spermidine C00315 146.1651 0.59 Spermine C00750 203.2227 0.61 D-Glucosamine C00329 180.0875 1.67 Carnosine C00386 227.1151 0.64 5-Guanidino-2-oxopentanoate C03771 174.0872 0.67 Creatine C00300 132.0767 0.66 Creatinine C00791 114.0660 0.66 4-Acetamidobutanoate C02946 146.0811 0.68 N-Acetylornithine C00437 175.1076 0.68 Guanidinoacetate C00581 118.0613 0.65 trans-4-Hydroxy-L-proline C01157 132.0656 0.67 Pantothenol C00864 220.1174 1.69 5-6-Dihydrouracil C00429 115.0502 0.68 Pantetheine C00831 279.1335 1.69 Pantetheine 4--phosphate C01134 359.1067 0.86 Taurine C00245 126.0219 0.67 L-Methionine S-oxide C02989 166.0531 0.84 5-Hydroxyindoleacetate C05635 192.0654 1.80 Indole C00463 118.0650 1.72 Indolepyruvate C00331 204.0654 1.84 Indoxyl C05658 134.0599 1.84 kynurenine C00328 209.0917 0.68 N-formyl kynurenine C02700 237.0868 1.79 Anthranilate C00108 138.0549 0.67 g-Oxalo-crotonate C03453 159.0277 0.68 Hydroxyindole-acetylglycine C05832 249.0867 1.78 L-Adrenaline C00788 184.0967 1.88 Dopamine C03758 154.0862 1.79 Ectoine C06231 143.0814 0.67 N-Methylethanolamine phosphate C01210 156.0420 0.65 Sphingosine C00319 300.2891 1.98 Acetylcholine C01996 146.1175 0.67 L-Carnitine C00318 162.1123 0.65 acetyl-carnitine (acyl-C2) C02571 204.1228 0.68 propionyl-carnitine (acyl-C3) C03017 218.1384 0.68 butanoyl-l-carnitine (acyl-C4) C02862 232.1541 1.71 acyl-C4-OH (Hydroxybutyrylcarnitine) HMDB13127 248.1486 0.68 acyl-C5:1 (Tiglylcarnitine) HMDB02366 244.1540 1.82 acyl-C5-OH (hydroxyisovalerylcarnitine) ac107 262.1642 0.68 hexanoyl-L-carnitine (acyl-C6) HMDB00756 260.1854 1.77 L-octanoylcarnitine (acyl-C8) C02838 288.2164 1.82 octenoyl-l-carnitine (acyl-C8:1) ac111 286.2007 1.79 O-Decenoyl-L-carnitine (acyl-C10:1) CID57357170 314.2319 1.85 O-dodecanoyl-carnitine (acyl-C12) HMDB02250 344.2791 1.93 O-dodecenoyl-carnitine (acyl-C12:1) HMDB13326 342.2636 1.91 O-tetradecanoyl-L-carnitine (acyl-C14) HMDB05066 372.3103 1.99 Tetradecenoyl Carnitine (acyl-C14:1) HMDB13329 370.2947 1.96 L-Palmitoylcarnitine (acyl-C16) C02990 400.3417 2.06 Hexadecenoyl-carnitine (acyl-C16:1) HMDB06317 398.3261 2.01 O-octadecenoyl-L-carnitine (acyl-C18:1) HMDB06351 426.3573 2.07 acyl-C18:2 (Linoleoyl-CoA) HMDB01064 424.3415 2.02 acyl-C20:4 ac125 448.3406 2.01 METABOLITES_END #END