#METABOLOMICS WORKBENCH BPnorman_20220928_081002 DATATRACK_ID:3478 STUDY_ID:ST002297 ANALYSIS_ID:AN003752 PROJECT_ID:PR001471 VERSION 1 CREATED_ON September 30, 2022, 8:19 am #PROJECT PR:PROJECT_TITLE Metabolomic analysis in SONIA 2, a phase 3 international randomised-controlled PR:PROJECT_TITLE trial of nitisinone in alkaptonuria (AKU) PR:PROJECT_SUMMARY Abstract from main SONIA 2 publication: Background Alkaptonuria is a rare, PR:PROJECT_SUMMARY genetic, multisystem disease characterised by the accumulation of homogentisic PR:PROJECT_SUMMARY acid (HGA). No HGA-lowering therapy has been approved to date. The aim of SONIA PR:PROJECT_SUMMARY 2 was to investigate the efficacy and safety of once-daily nitisinone for PR:PROJECT_SUMMARY reducing HGA excretion in patients with alkaptonuria and to evaluate whether PR:PROJECT_SUMMARY nitisinone has a clinical benefit. Methods SONIA 2 was a 4-year, open-label, PR:PROJECT_SUMMARY evaluator-blind, randomised, no treatment controlled, parallel-group study done PR:PROJECT_SUMMARY at three sites in the UK, France, and Slovakia. Patients aged 25 years or older PR:PROJECT_SUMMARY with confirmed alkaptonuria and any clinical disease manifestations were PR:PROJECT_SUMMARY randomly assigned (1:1) to receive either oral nitisinone 10 mg daily or no PR:PROJECT_SUMMARY treatment. Patients could not be masked to treatment due to colour changes in PR:PROJECT_SUMMARY the urine, but the study was evaluator-blinded as far as possible. The primary PR:PROJECT_SUMMARY endpoint was daily urinary HGA excretion (u-HGA24) after 12 months. Clinical PR:PROJECT_SUMMARY evaluation Alkaptonuria Severity Score Index (cAKUSSI) score was assessed at 12, PR:PROJECT_SUMMARY 24, 36, and 48 months. Efficacy variables were analysed in all randomly assigned PR:PROJECT_SUMMARY patients with a valid u-HGA24 measurement at baseline. Safety variables were PR:PROJECT_SUMMARY analysed in all randomly assigned patients. The study was registered at PR:PROJECT_SUMMARY ClinicalTrials.gov (NCT01916382). Findings Between May 7, 2014, and Feb 16, PR:PROJECT_SUMMARY 2015, 139 patients were screened, of whom 138 were included in the study, with PR:PROJECT_SUMMARY 69 patients randomly assigned to each group. 55 patients in the nitisinone group PR:PROJECT_SUMMARY and 53 in the control group completed the study. u-HGA24 at 12 months was PR:PROJECT_SUMMARY significantly decreased by 99·7% in the nitisinone group compared with the PR:PROJECT_SUMMARY control group (adjusted geometric mean ratio of nitisinone/control 0·003 [95% PR:PROJECT_SUMMARY CI 0·003 to 0·004], p<0·0001). At 48 months, the increase in cAKUSSI score PR:PROJECT_SUMMARY from baseline was significantly lower in the nitisinone group compared with the PR:PROJECT_SUMMARY control group (adjusted mean difference –8·6 points [–16·0 to –1·2], PR:PROJECT_SUMMARY p=0·023). 400 adverse events occurred in 59 (86%) patients in the nitisinone PR:PROJECT_SUMMARY group and 284 events occurred in 57 (83%) patients in the control group. No PR:PROJECT_SUMMARY treatment-related deaths occurred. Interpretation Nitisinone 10 mg daily was PR:PROJECT_SUMMARY well tolerated and effective in reducing urinary excretion of HGA. Nitisinone PR:PROJECT_SUMMARY decreased ochronosis and improved clinical signs, indicating a slower disease PR:PROJECT_SUMMARY progression. PR:INSTITUTE University of Liverpool Institute of Life Course & Medical Sciences PR:DEPARTMENT Department of Musculoskeletal & Ageing Science PR:LAST_NAME Brendan PR:FIRST_NAME Norman PR:ADDRESS William Henry Duncan Building, 6 West Derby Street, Liverpool, UK. L7 8TX PR:EMAIL bnorman@liverpool.ac.uk PR:PHONE +447809606497 PR:FUNDING_SOURCE European Commission for the Framework 7 grant award (DevelopAKUre, project PR:FUNDING_SOURCE number: 304985), Alkaptonuria Society (BPN is funded by the Alkaptonuria Society PR:FUNDING_SOURCE through a Sireau Fellowship Award). #STUDY ST:STUDY_TITLE Comprehensive biotransformation analysis of phenylalanine-tyrosine metabolism ST:STUDY_TITLE reveals alternative routes of metabolite clearance in nitisinone-treated ST:STUDY_TITLE alkaptonuria (Urine metabolomic analysis) ST:STUDY_SUMMARY Background: Metabolomic analyses in alkaptonuria (AKU) have recently revealed ST:STUDY_SUMMARY alternative pathways in phenylalanine-tyrosine (phe-tyr) metabolism from ST:STUDY_SUMMARY biotransformation of homo-gentisic acid (HGA), the active molecule in this ST:STUDY_SUMMARY disease. The aim of this research was to study the phe-tyr metabolic pathway and ST:STUDY_SUMMARY whether the metabolites upstream of HGA, increased in nitisinone-treated ST:STUDY_SUMMARY patients, also undergo phase 1 and 2 biotransformation reactions. Methods: ST:STUDY_SUMMARY Metabolomic analyses were performed on serum and urine from patients partaking ST:STUDY_SUMMARY in the SONIA 2 phase 3 international randomised-controlled trial of nitisinone ST:STUDY_SUMMARY in AKU (EudraCT no. 2013-001633-41). Serum and urine samples were taken from the ST:STUDY_SUMMARY same patients at baseline (pre-nitisinone) then at 24 and 48 months on ST:STUDY_SUMMARY nitisinone treatment (patients N = 47 serum; 53 urine) or no treatment (patients ST:STUDY_SUMMARY N = 45 serum; 50 urine). Targeted feature extraction was per-formed to ST:STUDY_SUMMARY specifically mine data for the entire complement of theoretically predicted ST:STUDY_SUMMARY phase 1 and 2 biotransformation products derived from phenylalanine, tyrosine, ST:STUDY_SUMMARY 4-hydroxyphenylpyruvic acid and 4-hydroxyphenyllactic acid, in addition to ST:STUDY_SUMMARY phenylalanine-derived metabolites with known increases in phenylketonuria. ST:STUDY_SUMMARY Results: In total, we ob-served 13 phase 1 and 2 biotransformation products from ST:STUDY_SUMMARY phenylalanine through to HGA. Each of these products were observed in urine and ST:STUDY_SUMMARY two were detected in serum. The derivatives of the metabolites upstream of HGA ST:STUDY_SUMMARY were markedly increased in urine of nitisinone-treated patients (fold change ST:STUDY_SUMMARY 1.2-16.2) and increases in 12 of these compounds were directly proportional to ST:STUDY_SUMMARY the degree of nitisinone-induced hypertyrosinaemia (correlation coefficient with ST:STUDY_SUMMARY serum tyrosine = 0.2-0.7). Increases in the urinary phenylalanine metabolites ST:STUDY_SUMMARY were also observed across consecutive visits in the treated group. Conclusions: ST:STUDY_SUMMARY Nitisinone treatment results in marked increases in a wider network of phe-tyr ST:STUDY_SUMMARY metabolites than shown before. This network comprises alternative ST:STUDY_SUMMARY biotransformation products from the major metabolites of this pathway, produced ST:STUDY_SUMMARY by reactions including hydration (phase 1) and bioconjugation (phase 2) of ST:STUDY_SUMMARY acetyl, methyl, acetylcysteine, glucuronide, glycine and sulfate groups. We ST:STUDY_SUMMARY propose that these alternative routes of phe-tyr metabolism, predominantly in ST:STUDY_SUMMARY urine, minimise tyrosinaemia as well as phenylalanaemia. ST:INSTITUTE University of Liverpool Institute of Life Course & Medical Sciences ST:DEPARTMENT Department of Musculoskeletal & Ageing Science ST:LAST_NAME Brendan ST:FIRST_NAME Norman ST:ADDRESS William Henry Duncan Building, 6 West Derby Street, Liverpool, UK. L7 8TX ST:EMAIL bnorman@liverpool.ac.uk ST:NUM_GROUPS 2 ST:TOTAL_SUBJECTS 103 ST:NUM_MALES 65 ST:NUM_FEMALES 38 ST:STUDY_TYPE Urine metabolomic analysis (study 2 of 2) ST:PHONE +447809606497 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS F01 F01_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=7.1; sTyr groups=1) <701; RAW_FILE_NAME=F01_V1 SUBJECT_SAMPLE_FACTORS F01 F01_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=6.3; sTyr groups=3) 901-1100; RAW_FILE_NAME=F01_V4 SUBJECT_SAMPLE_FACTORS F01 F01_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=2.5; sTyr groups=3) 901-1100; RAW_FILE_NAME=F01_V6 SUBJECT_SAMPLE_FACTORS F02 F02_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=11.9; sTyr groups=None; RAW_FILE_NAME=F02_V1 SUBJECT_SAMPLE_FACTORS F02 F02_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=12.2; sTyr groups=None; RAW_FILE_NAME=F02_V4 SUBJECT_SAMPLE_FACTORS F02 F02_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7.5; sTyr groups=None; RAW_FILE_NAME=F2_V6 SUBJECT_SAMPLE_FACTORS F03 F03_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=15; sTyr groups=None; RAW_FILE_NAME=F03_V1 SUBJECT_SAMPLE_FACTORS F03 F03_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=13.8; sTyr groups=None; RAW_FILE_NAME=F03_V4 SUBJECT_SAMPLE_FACTORS F03 F03_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=11; sTyr groups=None; RAW_FILE_NAME=F03_V6 SUBJECT_SAMPLE_FACTORS F04 F04_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=9.5; sTyr groups=1) <701; RAW_FILE_NAME=F04_V1 SUBJECT_SAMPLE_FACTORS F04 F04_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=13.3; sTyr groups=2) 701-900; RAW_FILE_NAME=F04_V4 SUBJECT_SAMPLE_FACTORS F04 F04_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11.4; sTyr groups=1) <701; RAW_FILE_NAME=F04_V6 SUBJECT_SAMPLE_FACTORS F05 F05_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=14.5; sTyr groups=1) <701; RAW_FILE_NAME=F05_V1 SUBJECT_SAMPLE_FACTORS F05 F05_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=10.7; sTyr groups=3) 901-1100; RAW_FILE_NAME=F05_V4 SUBJECT_SAMPLE_FACTORS F05 F05_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=8.1; sTyr groups=4) >1100; RAW_FILE_NAME=F05_V6 SUBJECT_SAMPLE_FACTORS F06 F06_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.9; sTyr groups=None; RAW_FILE_NAME=F06_V1 SUBJECT_SAMPLE_FACTORS F06 F06_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=19.5; sTyr groups=None; RAW_FILE_NAME=F06_V4 SUBJECT_SAMPLE_FACTORS F06 F06_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=4.9; sTyr groups=None; RAW_FILE_NAME=F06_V6 SUBJECT_SAMPLE_FACTORS F07 F07_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=8.3; sTyr groups=None; RAW_FILE_NAME=F07_V1 SUBJECT_SAMPLE_FACTORS F07 F07_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=7.7; sTyr groups=None; RAW_FILE_NAME=F07_V4 SUBJECT_SAMPLE_FACTORS F07 F07_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=2.9; sTyr groups=None; RAW_FILE_NAME=F07_V6 SUBJECT_SAMPLE_FACTORS F08 F08_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=13.3; sTyr groups=1) <701; RAW_FILE_NAME=F08_V1 SUBJECT_SAMPLE_FACTORS F08 F08_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=15.8; sTyr groups=4) >1100; RAW_FILE_NAME=F08_V4 SUBJECT_SAMPLE_FACTORS F08 F08_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=15.9; sTyr groups=3) 901-1100; RAW_FILE_NAME=F08_V6 SUBJECT_SAMPLE_FACTORS F09 F09_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10.8; sTyr groups=1) <701; RAW_FILE_NAME=F09_V1 SUBJECT_SAMPLE_FACTORS F09 F09_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=5.1; sTyr groups=2) 701-900; RAW_FILE_NAME=F09_V4 SUBJECT_SAMPLE_FACTORS F09 F09_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7.3; sTyr groups=2) 701-900; RAW_FILE_NAME=F09_V6 SUBJECT_SAMPLE_FACTORS F10 F10_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.1; sTyr groups=None; RAW_FILE_NAME=F10_V1 SUBJECT_SAMPLE_FACTORS F10 F10_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=5.5; sTyr groups=None; RAW_FILE_NAME=F10_V4 SUBJECT_SAMPLE_FACTORS F10 F10_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=3.6; sTyr groups=None; RAW_FILE_NAME=F10_V6 SUBJECT_SAMPLE_FACTORS F11 F11_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=6.8; sTyr groups=1) <701; RAW_FILE_NAME=F11_V1 SUBJECT_SAMPLE_FACTORS F11 F11_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=6; sTyr groups=4) >1100; RAW_FILE_NAME=F11_V4 SUBJECT_SAMPLE_FACTORS F11 F11_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=6; sTyr groups=2) 701-900; RAW_FILE_NAME=F11_V6 SUBJECT_SAMPLE_FACTORS F12 F12_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.5; sTyr groups=None; RAW_FILE_NAME=F12_V1 SUBJECT_SAMPLE_FACTORS F12 F12_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=5; sTyr groups=None; RAW_FILE_NAME=F12_V4 SUBJECT_SAMPLE_FACTORS F12 F12_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7.25; sTyr groups=None; RAW_FILE_NAME=F12_V6 SUBJECT_SAMPLE_FACTORS F13 F13_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=13.7; sTyr groups=None; RAW_FILE_NAME=F13_V1 SUBJECT_SAMPLE_FACTORS F13 F13_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=10.8; sTyr groups=None; RAW_FILE_NAME=F13_V4 SUBJECT_SAMPLE_FACTORS F13 F13_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=6.6; sTyr groups=None; RAW_FILE_NAME=F13_V6 SUBJECT_SAMPLE_FACTORS F14 F14_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=12.3; sTyr groups=None; RAW_FILE_NAME=F14_V1 SUBJECT_SAMPLE_FACTORS F14 F14_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=24.7; sTyr groups=None; RAW_FILE_NAME=F14_V4 SUBJECT_SAMPLE_FACTORS F14 F14_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=6.4; sTyr groups=None; RAW_FILE_NAME=F14_V6 SUBJECT_SAMPLE_FACTORS F15 F15_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=5.6; sTyr groups=1) <701; RAW_FILE_NAME=F15_V1 SUBJECT_SAMPLE_FACTORS F15 F15_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=7.9; sTyr groups=4) >1100; RAW_FILE_NAME=F15_V4 SUBJECT_SAMPLE_FACTORS F15 F15_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=3.8; sTyr groups=4) >1100; RAW_FILE_NAME=F15_V6 SUBJECT_SAMPLE_FACTORS F16 F16_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=4.3; sTyr groups=1) <701; RAW_FILE_NAME=F16_V1 SUBJECT_SAMPLE_FACTORS F16 F16_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=8.8; sTyr groups=3) 901-1100; RAW_FILE_NAME=F16_V4 SUBJECT_SAMPLE_FACTORS F16 F16_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=2.4; sTyr groups=3) 901-1100; RAW_FILE_NAME=F16_V6 SUBJECT_SAMPLE_FACTORS F17 F17_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=6.5; sTyr groups=1) <701; RAW_FILE_NAME=F17_V1 SUBJECT_SAMPLE_FACTORS F17 F17_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=2.5; sTyr groups=3) 901-1100; RAW_FILE_NAME=F17_V4 SUBJECT_SAMPLE_FACTORS F17 F17_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=5.1; sTyr groups=2) 701-900; RAW_FILE_NAME=F17_V6 SUBJECT_SAMPLE_FACTORS F18 F18_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=6.5; sTyr groups=None; RAW_FILE_NAME=F18_V1 SUBJECT_SAMPLE_FACTORS F18 F18_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=11.4; sTyr groups=None; RAW_FILE_NAME=F18_V4 SUBJECT_SAMPLE_FACTORS F18 F18_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=1.6; sTyr groups=None; RAW_FILE_NAME=F18_V6 SUBJECT_SAMPLE_FACTORS F20 F20_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10.3; sTyr groups=1) <701; RAW_FILE_NAME=F20_V1 SUBJECT_SAMPLE_FACTORS F20 F20_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=3.6; sTyr groups=4) >1100; RAW_FILE_NAME=F20_V4 SUBJECT_SAMPLE_FACTORS F20 F20_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=4.6; sTyr groups=4) >1100; RAW_FILE_NAME=F20_V6 SUBJECT_SAMPLE_FACTORS F21 F21_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=14.9; sTyr groups=None; RAW_FILE_NAME=F21_V1 SUBJECT_SAMPLE_FACTORS F21 F21_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=10.9; sTyr groups=None; RAW_FILE_NAME=F21_V4 SUBJECT_SAMPLE_FACTORS F21 F21_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=5.2; sTyr groups=None; RAW_FILE_NAME=F21_V6 SUBJECT_SAMPLE_FACTORS F23 F23_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=8.2; sTyr groups=None; RAW_FILE_NAME=F23_V1 SUBJECT_SAMPLE_FACTORS F23 F23_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=7.85; sTyr groups=None; RAW_FILE_NAME=F23_V4 SUBJECT_SAMPLE_FACTORS F23 F23_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7.5; sTyr groups=None; RAW_FILE_NAME=F23_V6 SUBJECT_SAMPLE_FACTORS F24 F24_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=9.1; sTyr groups=1) <701; RAW_FILE_NAME=F24_V1 SUBJECT_SAMPLE_FACTORS F24 F24_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=9.6; sTyr groups=2) 701-900; RAW_FILE_NAME=F24_V4 SUBJECT_SAMPLE_FACTORS F24 F24_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=5.8; sTyr groups=2) 701-900; RAW_FILE_NAME=F24_V6 SUBJECT_SAMPLE_FACTORS F25 F25_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=10.6; sTyr groups=None; RAW_FILE_NAME=F25_V1 SUBJECT_SAMPLE_FACTORS F25 F25_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=21.6; sTyr groups=None; RAW_FILE_NAME=F25_V4 SUBJECT_SAMPLE_FACTORS F25 F25_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=8.9; sTyr groups=None; RAW_FILE_NAME=F25_V6 SUBJECT_SAMPLE_FACTORS F26 F26_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=8.3; sTyr groups=1) <701; RAW_FILE_NAME=F26_V1 SUBJECT_SAMPLE_FACTORS F26 F26_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=15.1; sTyr groups=2) 701-900; RAW_FILE_NAME=F26_V4 SUBJECT_SAMPLE_FACTORS F26 F26_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=6.2; sTyr groups=3) 901-1100; RAW_FILE_NAME=F26_V6 SUBJECT_SAMPLE_FACTORS F29 F29_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12; sTyr groups=1) <701; RAW_FILE_NAME=F29_V1 SUBJECT_SAMPLE_FACTORS F29 F29_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=6.1; sTyr groups=2) 701-900; RAW_FILE_NAME=F29_V4 SUBJECT_SAMPLE_FACTORS F29 F29_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=6.7; sTyr groups=2) 701-900; RAW_FILE_NAME=F29_V6 SUBJECT_SAMPLE_FACTORS F31 F31_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10.4; sTyr groups=1) <701; RAW_FILE_NAME=F31_V1 SUBJECT_SAMPLE_FACTORS F31 F31_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=14.3; sTyr groups=1) <701; RAW_FILE_NAME=F31_V4 SUBJECT_SAMPLE_FACTORS F31 F31_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11; sTyr groups=1) <701; RAW_FILE_NAME=F31_V6 SUBJECT_SAMPLE_FACTORS F32 F32_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=7.7; sTyr groups=1) <701; RAW_FILE_NAME=F32_V1 SUBJECT_SAMPLE_FACTORS F32 F32_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=14.1; sTyr groups=2) 701-900; RAW_FILE_NAME=F32_V4 SUBJECT_SAMPLE_FACTORS F32 F32_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=2.4; sTyr groups=2) 701-900; RAW_FILE_NAME=F32_V6 SUBJECT_SAMPLE_FACTORS L01 L01_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=11.7; sTyr groups=None; RAW_FILE_NAME=L01_V1 SUBJECT_SAMPLE_FACTORS L01 L01_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=14.8; sTyr groups=None; RAW_FILE_NAME=L01_V4 SUBJECT_SAMPLE_FACTORS L01 L01_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=10; sTyr groups=None; RAW_FILE_NAME=L01_V6 SUBJECT_SAMPLE_FACTORS L03 L03_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=8.9; sTyr groups=None; RAW_FILE_NAME=L03_V1 SUBJECT_SAMPLE_FACTORS L03 L03_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=10.7; sTyr groups=None; RAW_FILE_NAME=L3_V4 SUBJECT_SAMPLE_FACTORS L03 L03_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=5.6; sTyr groups=None; RAW_FILE_NAME=L03_V6 SUBJECT_SAMPLE_FACTORS L06 L06_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=6.9; sTyr groups=1) <701; RAW_FILE_NAME=L06_V1 SUBJECT_SAMPLE_FACTORS L06 L06_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=7.3; sTyr groups=1) <701; RAW_FILE_NAME=L06_V4 SUBJECT_SAMPLE_FACTORS L06 L06_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=3.4; sTyr groups=4) >1100; RAW_FILE_NAME=L06_V6 SUBJECT_SAMPLE_FACTORS L07 L07_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=8.8; sTyr groups=1) <701; RAW_FILE_NAME=L07_V1 SUBJECT_SAMPLE_FACTORS L07 L07_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=6.5; sTyr groups=3) 901-1100; RAW_FILE_NAME=L07_V4 SUBJECT_SAMPLE_FACTORS L07 L07_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7.7; sTyr groups=3) 901-1100; RAW_FILE_NAME=L07_V6 SUBJECT_SAMPLE_FACTORS L08 L08_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.8; sTyr groups=1) <701; RAW_FILE_NAME=L08_V1 SUBJECT_SAMPLE_FACTORS L08 L08_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=11.4; sTyr groups=1) <701; RAW_FILE_NAME=L08_V4 SUBJECT_SAMPLE_FACTORS L08 L08_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11.3; sTyr groups=1) <701; RAW_FILE_NAME=L08_V6 SUBJECT_SAMPLE_FACTORS L09 L09_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=4.5; sTyr groups=None; RAW_FILE_NAME=L09_V1 SUBJECT_SAMPLE_FACTORS L09 L09_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=6; sTyr groups=None; RAW_FILE_NAME=L09_V4 SUBJECT_SAMPLE_FACTORS L09 L09_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=5.5; sTyr groups=None; RAW_FILE_NAME=L09_V6 SUBJECT_SAMPLE_FACTORS L10 L10_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=6.2; sTyr groups=1) <701; RAW_FILE_NAME=L10_V1 SUBJECT_SAMPLE_FACTORS L10 L10_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=6.6; sTyr groups=2) 701-900; RAW_FILE_NAME=L10_V4 SUBJECT_SAMPLE_FACTORS L10 L10_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7.4; sTyr groups=3) 901-1100; RAW_FILE_NAME=L10_V6 SUBJECT_SAMPLE_FACTORS L11 L11_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.1; sTyr groups=None; RAW_FILE_NAME=L11_V1 SUBJECT_SAMPLE_FACTORS L11 L11_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=6.6; sTyr groups=None; RAW_FILE_NAME=L11_V4 SUBJECT_SAMPLE_FACTORS L11 L11_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=4.7; sTyr groups=None; RAW_FILE_NAME=L11_V6 SUBJECT_SAMPLE_FACTORS L12 L12_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=8.4; sTyr groups=1) <701; RAW_FILE_NAME=L12_V1 SUBJECT_SAMPLE_FACTORS L12 L12_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=11.2; sTyr groups=2) 701-900; RAW_FILE_NAME=L12_V4 SUBJECT_SAMPLE_FACTORS L12 L12_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=8.6; sTyr groups=3) 901-1100; RAW_FILE_NAME=L12_V6 SUBJECT_SAMPLE_FACTORS L13 L13_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=10.2; sTyr groups=None; RAW_FILE_NAME=L13_V1 SUBJECT_SAMPLE_FACTORS L13 L13_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=6.4; sTyr groups=None; RAW_FILE_NAME=L13_V4 SUBJECT_SAMPLE_FACTORS L13 L13_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7; sTyr groups=None; RAW_FILE_NAME=L13_V6 SUBJECT_SAMPLE_FACTORS L14 L14_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10.2; sTyr groups=1) <701; RAW_FILE_NAME=L14_V1 SUBJECT_SAMPLE_FACTORS L14 L14_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=13.5; sTyr groups=2) 701-900; RAW_FILE_NAME=L14_V4 SUBJECT_SAMPLE_FACTORS L14 L14_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7.9; sTyr groups=2) 701-900; RAW_FILE_NAME=L14_V6 SUBJECT_SAMPLE_FACTORS L15 L15_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=13.2; sTyr groups=None; RAW_FILE_NAME=L15_V1 SUBJECT_SAMPLE_FACTORS L15 L15_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=11.3; sTyr groups=None; RAW_FILE_NAME=L15_V4 SUBJECT_SAMPLE_FACTORS L15 L15_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7.6; sTyr groups=None; RAW_FILE_NAME=L15_V6 SUBJECT_SAMPLE_FACTORS L16 L16_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=14.3; sTyr groups=1) <701; RAW_FILE_NAME=L16_V1 SUBJECT_SAMPLE_FACTORS L16 L16_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=11.2; sTyr groups=3) 901-1100; RAW_FILE_NAME=L16_V4 SUBJECT_SAMPLE_FACTORS L16 L16_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=8.7; sTyr groups=3) 901-1100; RAW_FILE_NAME=L16_V6 SUBJECT_SAMPLE_FACTORS L17 L17_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=13.7; sTyr groups=None; RAW_FILE_NAME=L17_V1 SUBJECT_SAMPLE_FACTORS L17 L17_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=13.5; sTyr groups=None; RAW_FILE_NAME=L17_V4 SUBJECT_SAMPLE_FACTORS L17 L17_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7.2; sTyr groups=None; RAW_FILE_NAME=L17_V6 SUBJECT_SAMPLE_FACTORS L18 L18_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.5; sTyr groups=1) <701; RAW_FILE_NAME=L18_V1 SUBJECT_SAMPLE_FACTORS L18 L18_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=10.5; sTyr groups=3) 901-1100; RAW_FILE_NAME=L18_V4 SUBJECT_SAMPLE_FACTORS L18 L18_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=10.6; sTyr groups=3) 901-1100; RAW_FILE_NAME=L18_V6 SUBJECT_SAMPLE_FACTORS L21 L21_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=8.6; sTyr groups=None; RAW_FILE_NAME=L21_V1 SUBJECT_SAMPLE_FACTORS L21 L21_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=9.9; sTyr groups=None; RAW_FILE_NAME=L21_V4 SUBJECT_SAMPLE_FACTORS L21 L21_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=6.8; sTyr groups=None; RAW_FILE_NAME=L21_V6 SUBJECT_SAMPLE_FACTORS L22 L22_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=9.4; sTyr groups=1) <701; RAW_FILE_NAME=L22_V1 SUBJECT_SAMPLE_FACTORS L22 L22_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=10.5; sTyr groups=1) <701; RAW_FILE_NAME=L22_V4 SUBJECT_SAMPLE_FACTORS L22 L22_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=4.3; sTyr groups=1) <701; RAW_FILE_NAME=L22_V6 SUBJECT_SAMPLE_FACTORS L23 L23_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=8.2; sTyr groups=None; RAW_FILE_NAME=L23_V1 SUBJECT_SAMPLE_FACTORS L23 L23_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=8.3; sTyr groups=None; RAW_FILE_NAME=L23_V4 SUBJECT_SAMPLE_FACTORS L23 L23_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=3.4; sTyr groups=None; RAW_FILE_NAME=L23_V6 SUBJECT_SAMPLE_FACTORS L24 L24_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=12.1; sTyr groups=None; RAW_FILE_NAME=L24_V1 SUBJECT_SAMPLE_FACTORS L24 L24_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=13.4; sTyr groups=None; RAW_FILE_NAME=L24_V4 SUBJECT_SAMPLE_FACTORS L24 L24_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7.7; sTyr groups=None; RAW_FILE_NAME=L24_V6 SUBJECT_SAMPLE_FACTORS L28 L28_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.9; sTyr groups=1) <701; RAW_FILE_NAME=L28_V1 SUBJECT_SAMPLE_FACTORS L28 L28_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=13.3; sTyr groups=4) >1100; RAW_FILE_NAME=L28_V4 SUBJECT_SAMPLE_FACTORS L28 L28_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11.9; sTyr groups=4) >1100; RAW_FILE_NAME=L28_V6 SUBJECT_SAMPLE_FACTORS L29 L29_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=7.7; sTyr groups=None; RAW_FILE_NAME=L29_V1 SUBJECT_SAMPLE_FACTORS L29 L29_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=9; sTyr groups=None; RAW_FILE_NAME=L29_V4 SUBJECT_SAMPLE_FACTORS L29 L29_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=5.5; sTyr groups=None; RAW_FILE_NAME=L29_V6 SUBJECT_SAMPLE_FACTORS L30 L30_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=11.6; sTyr groups=1) <701; RAW_FILE_NAME=L30_V1 SUBJECT_SAMPLE_FACTORS L30 L30_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=12.7; sTyr groups=3) 901-1100; RAW_FILE_NAME=L30_V4 SUBJECT_SAMPLE_FACTORS L30 L30_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7; sTyr groups=4) >1100; RAW_FILE_NAME=L30_V6 SUBJECT_SAMPLE_FACTORS L31 L31_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=6.9; sTyr groups=None; RAW_FILE_NAME=L31_V1 SUBJECT_SAMPLE_FACTORS L31 L31_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=5.6; sTyr groups=None; RAW_FILE_NAME=L31_V4 SUBJECT_SAMPLE_FACTORS L31 L31_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=3.4; sTyr groups=None; RAW_FILE_NAME=L31_V6 SUBJECT_SAMPLE_FACTORS L33 L33_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=8.7; sTyr groups=1) <701; RAW_FILE_NAME=L33_V1 SUBJECT_SAMPLE_FACTORS L33 L33_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=8.3; sTyr groups=2) 701-900; RAW_FILE_NAME=L33_V4 SUBJECT_SAMPLE_FACTORS L33 L33_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=5.2; sTyr groups=2) 701-900; RAW_FILE_NAME=L33_V6 SUBJECT_SAMPLE_FACTORS L35 L35_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=13.9; sTyr groups=1) <701; RAW_FILE_NAME=L35_V1 SUBJECT_SAMPLE_FACTORS L35 L35_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=9.8; sTyr groups=1) <701; RAW_FILE_NAME=L35_V4 SUBJECT_SAMPLE_FACTORS L35 L35_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7.4; sTyr groups=1) <701; RAW_FILE_NAME=L35_V6 SUBJECT_SAMPLE_FACTORS L37 L37_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=11.7; sTyr groups=None; RAW_FILE_NAME=L37_V1 SUBJECT_SAMPLE_FACTORS L37 L37_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=14.6; sTyr groups=None; RAW_FILE_NAME=L37_V4 SUBJECT_SAMPLE_FACTORS L37 L37_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=11.7; sTyr groups=None; RAW_FILE_NAME=L37_V6 SUBJECT_SAMPLE_FACTORS L38 L38_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=7.5; sTyr groups=None; RAW_FILE_NAME=L38_V1 SUBJECT_SAMPLE_FACTORS L38 L38_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=9.5; sTyr groups=None; RAW_FILE_NAME=L38_V4 SUBJECT_SAMPLE_FACTORS L38 L38_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=4.7; sTyr groups=None; RAW_FILE_NAME=L38_V6 SUBJECT_SAMPLE_FACTORS L40 L40_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10.5; sTyr groups=1) <701; RAW_FILE_NAME=L40_V1 SUBJECT_SAMPLE_FACTORS L40 L40_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=14.3; sTyr groups=1) <701; RAW_FILE_NAME=L40_V4 SUBJECT_SAMPLE_FACTORS L40 L40_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11; sTyr groups=2) 701-900; RAW_FILE_NAME=L40_V6 SUBJECT_SAMPLE_FACTORS P01 P01_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.4; sTyr groups=None; RAW_FILE_NAME=P01_V1 SUBJECT_SAMPLE_FACTORS P01 P01_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=9.5; sTyr groups=None; RAW_FILE_NAME=P01_V4 SUBJECT_SAMPLE_FACTORS P01 P01_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=10.9; sTyr groups=None; RAW_FILE_NAME=P01_V6 SUBJECT_SAMPLE_FACTORS P02 P02_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=9.3; sTyr groups=1) <701; RAW_FILE_NAME=P02_V1 SUBJECT_SAMPLE_FACTORS P02 P02_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=10.1; sTyr groups=3) 901-1100; RAW_FILE_NAME=P02_V4 SUBJECT_SAMPLE_FACTORS P02 P02_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=5; sTyr groups=2) 701-900; RAW_FILE_NAME=P02_V6 SUBJECT_SAMPLE_FACTORS P03 P03_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=14.6; sTyr groups=1) <701; RAW_FILE_NAME=P03_V1 SUBJECT_SAMPLE_FACTORS P03 P03_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=17.6; sTyr groups=2) 701-900; RAW_FILE_NAME=P03_V4 SUBJECT_SAMPLE_FACTORS P03 P03_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=14.3; sTyr groups=2) 701-900; RAW_FILE_NAME=P03_V6 SUBJECT_SAMPLE_FACTORS P05 P05_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=10.1; sTyr groups=None; RAW_FILE_NAME=P05_V1 SUBJECT_SAMPLE_FACTORS P05 P05_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=14.6; sTyr groups=None; RAW_FILE_NAME=P05_V4 SUBJECT_SAMPLE_FACTORS P05 P05_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=5.6; sTyr groups=None; RAW_FILE_NAME=P05_V6 SUBJECT_SAMPLE_FACTORS P06 P06_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=12.5; sTyr groups=None; RAW_FILE_NAME=P06_V1 SUBJECT_SAMPLE_FACTORS P06 P06_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=12.7; sTyr groups=None; RAW_FILE_NAME=P06_V4 SUBJECT_SAMPLE_FACTORS P06 P06_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=11.1; sTyr groups=None; RAW_FILE_NAME=P06_V6 SUBJECT_SAMPLE_FACTORS P07 P07_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10.4; sTyr groups=1) <701; RAW_FILE_NAME=P07_V1 SUBJECT_SAMPLE_FACTORS P07 P07_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=10.7; sTyr groups=3) 901-1100; RAW_FILE_NAME=P07_V4 SUBJECT_SAMPLE_FACTORS P07 P07_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7; sTyr groups=2) 701-900; RAW_FILE_NAME=P07_V6 SUBJECT_SAMPLE_FACTORS P09 P09_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=12.6; sTyr groups=None; RAW_FILE_NAME=P09_V1 SUBJECT_SAMPLE_FACTORS P09 P09_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=14.3; sTyr groups=None; RAW_FILE_NAME=P09_V4 SUBJECT_SAMPLE_FACTORS P09 P09_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=12; sTyr groups=None; RAW_FILE_NAME=P09_V6 SUBJECT_SAMPLE_FACTORS P11 P11_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.2; sTyr groups=1) <701; RAW_FILE_NAME=P11_V1 SUBJECT_SAMPLE_FACTORS P11 P11_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=12.6; sTyr groups=3) 901-1100; RAW_FILE_NAME=P11_V4 SUBJECT_SAMPLE_FACTORS P11 P11_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=12.2; sTyr groups=3) 901-1100; RAW_FILE_NAME=P11_V6 SUBJECT_SAMPLE_FACTORS P12 P12_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=14.1; sTyr groups=None; RAW_FILE_NAME=P12_V1 SUBJECT_SAMPLE_FACTORS P12 P12_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=11.4; sTyr groups=None; RAW_FILE_NAME=P12_V4 SUBJECT_SAMPLE_FACTORS P12 P12_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=15.8; sTyr groups=None; RAW_FILE_NAME=P12_V6 SUBJECT_SAMPLE_FACTORS P13 P13_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.3; sTyr groups=None; RAW_FILE_NAME=P13_V1 SUBJECT_SAMPLE_FACTORS P13 P13_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=9.7; sTyr groups=None; RAW_FILE_NAME=P13_V4 SUBJECT_SAMPLE_FACTORS P13 P13_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=7.4; sTyr groups=None; RAW_FILE_NAME=P13_V6 SUBJECT_SAMPLE_FACTORS P15 P15_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=15.1; sTyr groups=1) <701; RAW_FILE_NAME=P15_V1 SUBJECT_SAMPLE_FACTORS P15 P15_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=12.3; sTyr groups=1) <701; RAW_FILE_NAME=P15_V4 SUBJECT_SAMPLE_FACTORS P15 P15_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=15.7; sTyr groups=1) <701; RAW_FILE_NAME=P15_V6 SUBJECT_SAMPLE_FACTORS P16 P16_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=8.5; sTyr groups=None; RAW_FILE_NAME=P16_V1 SUBJECT_SAMPLE_FACTORS P16 P16_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=10.3; sTyr groups=None; RAW_FILE_NAME=P16_V4 SUBJECT_SAMPLE_FACTORS P16 P16_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=10.1; sTyr groups=None; RAW_FILE_NAME=P16_V6 SUBJECT_SAMPLE_FACTORS P17 P17_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=15.8; sTyr groups=None; RAW_FILE_NAME=P17_V1 SUBJECT_SAMPLE_FACTORS P17 P17_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=13.8; sTyr groups=None; RAW_FILE_NAME=P17_V4 SUBJECT_SAMPLE_FACTORS P17 P17_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=8.3; sTyr groups=None; RAW_FILE_NAME=P17_V6 SUBJECT_SAMPLE_FACTORS P18 P18_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=14.2; sTyr groups=1) <701; RAW_FILE_NAME=P18_V1 SUBJECT_SAMPLE_FACTORS P18 P18_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=14.2; sTyr groups=2) 701-900; RAW_FILE_NAME=P18_V4 SUBJECT_SAMPLE_FACTORS P18 P18_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11.8; sTyr groups=2) 701-900; RAW_FILE_NAME=P18_V6 SUBJECT_SAMPLE_FACTORS P20 P20_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=12.5; sTyr groups=None; RAW_FILE_NAME=P20_V1 SUBJECT_SAMPLE_FACTORS P20 P20_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=15.1; sTyr groups=None; RAW_FILE_NAME=P20_V4 SUBJECT_SAMPLE_FACTORS P20 P20_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=13.9; sTyr groups=None; RAW_FILE_NAME=P20_V6 SUBJECT_SAMPLE_FACTORS P21 P21_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=18.7; sTyr groups=None; RAW_FILE_NAME=P21_V1 SUBJECT_SAMPLE_FACTORS P21 P21_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=8.7; sTyr groups=None; RAW_FILE_NAME=P21_V4 SUBJECT_SAMPLE_FACTORS P21 P21_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=11.8; sTyr groups=None; RAW_FILE_NAME=P21_V6 SUBJECT_SAMPLE_FACTORS P22 P22_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=9.7; sTyr groups=1) <701; RAW_FILE_NAME=P22_V1 SUBJECT_SAMPLE_FACTORS P22 P22_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=9.6; sTyr groups=2) 701-900; RAW_FILE_NAME=P22_V4 SUBJECT_SAMPLE_FACTORS P22 P22_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=6.7; sTyr groups=4) >1100; RAW_FILE_NAME=P22_V6 SUBJECT_SAMPLE_FACTORS P23 P23_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=16.4; sTyr groups=1) <701; RAW_FILE_NAME=P23_V1 SUBJECT_SAMPLE_FACTORS P23 P23_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=13.9; sTyr groups=4) >1100; RAW_FILE_NAME=P23_V4 SUBJECT_SAMPLE_FACTORS P23 P23_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11.3; sTyr groups=3) 901-1100; RAW_FILE_NAME=P23_V6 SUBJECT_SAMPLE_FACTORS P24 P24_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=13.1; sTyr groups=None; RAW_FILE_NAME=P24_V1 SUBJECT_SAMPLE_FACTORS P24 P24_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=11.9; sTyr groups=None; RAW_FILE_NAME=P24_V4 SUBJECT_SAMPLE_FACTORS P24 P24_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=8.8; sTyr groups=None; RAW_FILE_NAME=P24_V6 SUBJECT_SAMPLE_FACTORS P26 P26_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.6; sTyr groups=1) <701; RAW_FILE_NAME=P26_V1 SUBJECT_SAMPLE_FACTORS P26 P26_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=12; sTyr groups=3) 901-1100; RAW_FILE_NAME=P26_V4 SUBJECT_SAMPLE_FACTORS P26 P26_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=12.5; sTyr groups=4) >1100; RAW_FILE_NAME=P26_V6 SUBJECT_SAMPLE_FACTORS P28 P28_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=18.4; sTyr groups=None; RAW_FILE_NAME=P28_V1 SUBJECT_SAMPLE_FACTORS P28 P28_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=13.9; sTyr groups=None; RAW_FILE_NAME=P28_V4 SUBJECT_SAMPLE_FACTORS P28 P28_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=18.6; sTyr groups=None; RAW_FILE_NAME=P28_V6 SUBJECT_SAMPLE_FACTORS P29 P29_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.9; sTyr groups=None; RAW_FILE_NAME=P29_V1 SUBJECT_SAMPLE_FACTORS P29 P29_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=7.6; sTyr groups=None; RAW_FILE_NAME=P29_V4 SUBJECT_SAMPLE_FACTORS P29 P29_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=9.6; sTyr groups=None; RAW_FILE_NAME=P29_V6 SUBJECT_SAMPLE_FACTORS P30 P30_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=13.6; sTyr groups=1) <701; RAW_FILE_NAME=P30_V1 SUBJECT_SAMPLE_FACTORS P30 P30_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=16; sTyr groups=3) 901-1100; RAW_FILE_NAME=P30_V4 SUBJECT_SAMPLE_FACTORS P30 P30_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=16.3; sTyr groups=1) <701; RAW_FILE_NAME=P30_V6 SUBJECT_SAMPLE_FACTORS P31 P31_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=9.7; sTyr groups=1) <701; RAW_FILE_NAME=P31_V1 SUBJECT_SAMPLE_FACTORS P31 P31_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=10.8; sTyr groups=4) >1100; RAW_FILE_NAME=P31_V4 SUBJECT_SAMPLE_FACTORS P31 P31_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=8.4; sTyr groups=3) 901-1100; RAW_FILE_NAME=P31_V6 SUBJECT_SAMPLE_FACTORS P32 P32_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.1; sTyr groups=None; RAW_FILE_NAME=P32_V1 SUBJECT_SAMPLE_FACTORS P32 P32_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=11.1; sTyr groups=None; RAW_FILE_NAME=P32_V4 SUBJECT_SAMPLE_FACTORS P32 P32_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=8.5; sTyr groups=None; RAW_FILE_NAME=P32_V6 SUBJECT_SAMPLE_FACTORS P33 P33_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=15.5; sTyr groups=None; RAW_FILE_NAME=P33_V1 SUBJECT_SAMPLE_FACTORS P33 P33_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=14.4; sTyr groups=None; RAW_FILE_NAME=P33_V4 SUBJECT_SAMPLE_FACTORS P33 P33_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=16.9; sTyr groups=None; RAW_FILE_NAME=P33_V6 SUBJECT_SAMPLE_FACTORS P34 P34_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.6; sTyr groups=1) <701; RAW_FILE_NAME=P34_V1 SUBJECT_SAMPLE_FACTORS P34 P34_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=15.3; sTyr groups=2) 701-900; RAW_FILE_NAME=P34_V4 SUBJECT_SAMPLE_FACTORS P34 P34_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=25.1; sTyr groups=2) 701-900; RAW_FILE_NAME=P34_V6 SUBJECT_SAMPLE_FACTORS P35 P35_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=6.1; sTyr groups=None; RAW_FILE_NAME=P35_V1 SUBJECT_SAMPLE_FACTORS P35 P35_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=7.3; sTyr groups=None; RAW_FILE_NAME=P35_V4 SUBJECT_SAMPLE_FACTORS P35 P35_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=8.2; sTyr groups=None; RAW_FILE_NAME=P35_V6 SUBJECT_SAMPLE_FACTORS P37 P37_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=15.8; sTyr groups=None; RAW_FILE_NAME=P37_V1 SUBJECT_SAMPLE_FACTORS P37 P37_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=15.7; sTyr groups=None; RAW_FILE_NAME=P37_V4 SUBJECT_SAMPLE_FACTORS P37 P37_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=4; sTyr groups=None; RAW_FILE_NAME=P37_V6 SUBJECT_SAMPLE_FACTORS P39 P39_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10.5; sTyr groups=1) <701; RAW_FILE_NAME=P39_V1 SUBJECT_SAMPLE_FACTORS P39 P39_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=8.6; sTyr groups=1) <701; RAW_FILE_NAME=P39_V4 SUBJECT_SAMPLE_FACTORS P39 P39_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=3.8; sTyr groups=1) <701; RAW_FILE_NAME=P39_V6 SUBJECT_SAMPLE_FACTORS P40 P40_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=8.4; sTyr groups=1) <701; RAW_FILE_NAME=P40_V1 SUBJECT_SAMPLE_FACTORS P40 P40_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=9.1; sTyr groups=1) <701; RAW_FILE_NAME=P40_V4 SUBJECT_SAMPLE_FACTORS P40 P40_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=9.6; sTyr groups=1) <701; RAW_FILE_NAME=P40_V6 SUBJECT_SAMPLE_FACTORS P41 P41_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=9.2; sTyr groups=None; RAW_FILE_NAME=P41_V1 SUBJECT_SAMPLE_FACTORS P41 P41_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=9.8; sTyr groups=None; RAW_FILE_NAME=P41_V4 SUBJECT_SAMPLE_FACTORS P41 P41_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=9.1; sTyr groups=None; RAW_FILE_NAME=P41_V6 SUBJECT_SAMPLE_FACTORS P42 P42_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=11.3; sTyr groups=None; RAW_FILE_NAME=P42_V1 SUBJECT_SAMPLE_FACTORS P42 P42_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=8.6; sTyr groups=None; RAW_FILE_NAME=P42_V4 SUBJECT_SAMPLE_FACTORS P42 P42_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=2.3; sTyr groups=None; RAW_FILE_NAME=P42_V6 SUBJECT_SAMPLE_FACTORS P43 P43_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=11.3; sTyr groups=1) <701; RAW_FILE_NAME=P43_V1 SUBJECT_SAMPLE_FACTORS P43 P43_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=8.9; sTyr groups=3) 901-1100; RAW_FILE_NAME=P43_V4 SUBJECT_SAMPLE_FACTORS P43 P43_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=8.7; sTyr groups=1) <701; RAW_FILE_NAME=P43_V6 SUBJECT_SAMPLE_FACTORS P44 P44_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=14.8; sTyr groups=1) <701; RAW_FILE_NAME=P44_V1 SUBJECT_SAMPLE_FACTORS P44 P44_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=15; sTyr groups=2) 701-900; RAW_FILE_NAME=P44_V4 SUBJECT_SAMPLE_FACTORS P44 P44_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=14.9; sTyr groups=2) 701-900; RAW_FILE_NAME=P44_V6 SUBJECT_SAMPLE_FACTORS P46 P46_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=8.8; sTyr groups=1) <701; RAW_FILE_NAME=P46_V1 SUBJECT_SAMPLE_FACTORS P46 P46_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=12.4; sTyr groups=1) <701; RAW_FILE_NAME=P46_V4 SUBJECT_SAMPLE_FACTORS P46 P46_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=2.3; sTyr groups=2) 701-900; RAW_FILE_NAME=P46_V6 SUBJECT_SAMPLE_FACTORS P47 P47_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.7; sTyr groups=1) <701; RAW_FILE_NAME=P47_V1 SUBJECT_SAMPLE_FACTORS P47 P47_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=12.1; sTyr groups=3) 901-1100; RAW_FILE_NAME=P47_V4 SUBJECT_SAMPLE_FACTORS P47 P47_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=8.3; sTyr groups=2) 701-900; RAW_FILE_NAME=P47_V6 SUBJECT_SAMPLE_FACTORS P48 P48_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=7.6; sTyr groups=1) <701; RAW_FILE_NAME=P48_V1 SUBJECT_SAMPLE_FACTORS P48 P48_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=13.7; sTyr groups=1) <701; RAW_FILE_NAME=P48_V4 SUBJECT_SAMPLE_FACTORS P48 P48_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=3.7; sTyr groups=2) 701-900; RAW_FILE_NAME=P48_V6 SUBJECT_SAMPLE_FACTORS P49 P49_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=13.8; sTyr groups=None; RAW_FILE_NAME=P49_V1 SUBJECT_SAMPLE_FACTORS P49 P49_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=13.7; sTyr groups=None; RAW_FILE_NAME=P49_V4 SUBJECT_SAMPLE_FACTORS P49 P49_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=9.2; sTyr groups=None; RAW_FILE_NAME=P49_V6 SUBJECT_SAMPLE_FACTORS P50 P50_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=11.6; sTyr groups=None; RAW_FILE_NAME=P50_V1 SUBJECT_SAMPLE_FACTORS P50 P50_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=10; sTyr groups=None; RAW_FILE_NAME=P50_V4 SUBJECT_SAMPLE_FACTORS P50 P50_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=4.6; sTyr groups=None; RAW_FILE_NAME=P50_V6 SUBJECT_SAMPLE_FACTORS P52 P52_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=12.2; sTyr groups=1) <701; RAW_FILE_NAME=P52_V1 SUBJECT_SAMPLE_FACTORS P52 P52_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=11.4; sTyr groups=2) 701-900; RAW_FILE_NAME=P52_V4 SUBJECT_SAMPLE_FACTORS P52 P52_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=6.4; sTyr groups=2) 701-900; RAW_FILE_NAME=P52_V6 SUBJECT_SAMPLE_FACTORS P55 P55_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=11.3; sTyr groups=1) <701; RAW_FILE_NAME=P55_V1 SUBJECT_SAMPLE_FACTORS P55 P55_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=12.4; sTyr groups=1) <701; RAW_FILE_NAME=P55_V4 SUBJECT_SAMPLE_FACTORS P55 P55_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11; sTyr groups=1) <701; RAW_FILE_NAME=P55_V6 SUBJECT_SAMPLE_FACTORS P60 P60_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=10; sTyr groups=1) <701; RAW_FILE_NAME=P60_V1 SUBJECT_SAMPLE_FACTORS P60 P60_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=8.9; sTyr groups=2) 701-900; RAW_FILE_NAME=P60_V4 SUBJECT_SAMPLE_FACTORS P60 P60_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=7; sTyr groups=1) <701; RAW_FILE_NAME=P60_V6 SUBJECT_SAMPLE_FACTORS P61 P61_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=12.1; sTyr groups=None; RAW_FILE_NAME=P61_V1 SUBJECT_SAMPLE_FACTORS P61 P61_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=11.8; sTyr groups=None; RAW_FILE_NAME=P61_V4 SUBJECT_SAMPLE_FACTORS P61 P61_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=11.4; sTyr groups=None; RAW_FILE_NAME=P61_V6 SUBJECT_SAMPLE_FACTORS P62 P62_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=14.9; sTyr groups=1) <701; RAW_FILE_NAME=P62_V1 SUBJECT_SAMPLE_FACTORS P62 P62_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=16.6; sTyr groups=2) 701-900; RAW_FILE_NAME=P62_V4 SUBJECT_SAMPLE_FACTORS P62 P62_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=11.8; sTyr groups=3) 901-1100; RAW_FILE_NAME=P62_V6 SUBJECT_SAMPLE_FACTORS P63 P63_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=5; sTyr groups=None; RAW_FILE_NAME=P63_V1 SUBJECT_SAMPLE_FACTORS P63 P63_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=6.1; sTyr groups=None; RAW_FILE_NAME=P63_V4 SUBJECT_SAMPLE_FACTORS P63 P63_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=10.3; sTyr groups=None; RAW_FILE_NAME=P63_V6 SUBJECT_SAMPLE_FACTORS P64 P64_V1 Treatedrial arm:Treated Time point=Baseline; 24h Creatinine=6.1; sTyr groups=1) <701; RAW_FILE_NAME=P64_V1 SUBJECT_SAMPLE_FACTORS P64 P64_V4 Treatedrial arm:Treated Time point=24 months; 24h Creatinine=8.2; sTyr groups=2) 701-900; RAW_FILE_NAME=P64_V4 SUBJECT_SAMPLE_FACTORS P64 P64_V6 Treatedrial arm:Treated Time point=48 months; 24h Creatinine=4; sTyr groups=2) 701-900; RAW_FILE_NAME=P64_V6 SUBJECT_SAMPLE_FACTORS P65 P65_V1 Treatedrial arm:Untreated Time point=Baseline; 24h Creatinine=10.3; sTyr groups=None; RAW_FILE_NAME=P65_V1 SUBJECT_SAMPLE_FACTORS P65 P65_V4 Treatedrial arm:Untreated Time point=24 months; 24h Creatinine=9.5; sTyr groups=None; RAW_FILE_NAME=P65_V4 SUBJECT_SAMPLE_FACTORS P65 P65_V6 Treatedrial arm:Untreated Time point=48 months; 24h Creatinine=13.4; sTyr groups=None; RAW_FILE_NAME=P65_V6 #COLLECTION CO:COLLECTION_SUMMARY Serum and urine samples were collected at the three study sites; Liverpool, CO:COLLECTION_SUMMARY Paris and Piešťany. Samples collected at Paris and Piešťany were transported CO:COLLECTION_SUMMARY frozen to the Royal Liverpool University Hospital for metabolite analysis and CO:COLLECTION_SUMMARY storage at -80 °C. Urine was collected over 24-h into 2.5 L bottles containing CO:COLLECTION_SUMMARY 30 mL of 5 mol/L sulphuric acid which was subsequently aliquoted and stored at CO:COLLECTION_SUMMARY -80 °C. CO:SAMPLE_TYPE Urine CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Samples studied were from patients partaking in the SONIA 2 clinical trial of TR:TREATMENT_SUMMARY nitisinone in AKU. SONIA 2 was a 4-year, open-label, evaluator-blind, TR:TREATMENT_SUMMARY randomised, no treatment controlled, parallel-group study undertaken at three TR:TREATMENT_SUMMARY study sites; Liverpool (UK), Paris (France) and Piešťany (Slovakia). The TR:TREATMENT_SUMMARY details and outcomes of the trial are published (1). Serum and urine samples TR:TREATMENT_SUMMARY were collected from participants at baseline (pre-treatment) then at 3 months TR:TREATMENT_SUMMARY and 1, 2, 3 and 4 years on 10 mg oral daily nitisinone (Orfadin®) treatment or TR:TREATMENT_SUMMARY no treatment. The serum and urine samples from visit 1 (baseline; TR:TREATMENT_SUMMARY pre-treatment), visit 4 (2 years), visit 6 (4 years) underwent metabolomic TR:TREATMENT_SUMMARY analysis. In this study, only the data from patients with samples available for TR:TREATMENT_SUMMARY these three time points were included; 53 and 50 patients in treated and TR:TREATMENT_SUMMARY untreated groups respectively for urine, and 47 and 45 patients in treated and TR:TREATMENT_SUMMARY untreated groups respectively for serum. Reference: (1) Ranganath, L.R.; TR:TREATMENT_SUMMARY Psarelli, E.E.; Arnoux, J.B.; Braconi, D.; Briggs, M.; Bröijersén, A.; Loftus, TR:TREATMENT_SUMMARY N.; Bygott, H.; Cox, T.F.; Davison, A.S.; et al. Efficacy and Safety of TR:TREATMENT_SUMMARY Once-Daily Nitisinone for Patients with Alkaptonuria (SONIA 2): An TR:TREATMENT_SUMMARY International, Multicentre, Open-Label, Randomised Controlled Trial. Lancet TR:TREATMENT_SUMMARY Diabetes Endocrinol. 2020, 8, 762–772, doi:10.1016/S2213-8587(20)30228-X. TR:TREATMENT_PROTOCOL_ID Clinical trial ID: EudraCT no. 2013-001633-41 TR:TREATMENT_COMPOUND Nitisinone (NTBC) TR:TREATMENT_DOSE 10 mg daily TR:TREATMENT_DOSEDURATION 48 months total #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Prior to analysis, urine samples were thawed at room temperature before SP:SAMPLEPREP_SUMMARY vortexing and centrifugation at 1500 ×g for 5 minutes. 150 µL of each urine SP:SAMPLEPREP_SUMMARY sample was aliquoted into a 1 mL 96-well plate (Waters Corporation, Wilmslow, SP:SAMPLEPREP_SUMMARY UK) and diluted with 450 µL of deionised water. Samples were mixed on a plate SP:SAMPLEPREP_SUMMARY shaker (MTS 2/4m IKA) at 600 rpm for 10 min and sub-aliquoted into multiple SP:SAMPLEPREP_SUMMARY replicate 96-well plates before storage at -80 °C ready for analysis. Prior to SP:SAMPLEPREP_SUMMARY analysis, sample plates were thawed then agitated on a plate shaker (MTS 2/4m SP:SAMPLEPREP_SUMMARY IKA) at 600 rpm for 10 min. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Analysis of serum and urine samples was performed using a published LC-QTOF-MS CH:CHROMATOGRAPHY_SUMMARY acquisition method, which employed a 1290 Infinity II HPLC coupled to a 6550 CH:CHROMATOGRAPHY_SUMMARY QTOF-MS equipped with dual AJS electrospray ionisation source (Agilent, Cheadle, CH:CHROMATOGRAPHY_SUMMARY UK). Data acquisition parameters are detailed in brief below and in full in CH:CHROMATOGRAPHY_SUMMARY Supplementary Materials. Reversed-phase LC was performed on an Atlantis dC18 CH:CHROMATOGRAPHY_SUMMARY column (3×100 mm, 3 μm, Waters, Manchester, UK) maintained at 60 °C. Mobile CH:CHROMATOGRAPHY_SUMMARY phase composition was (A) water and (B) methanol, both with 5 mmol/L ammonium CH:CHROMATOGRAPHY_SUMMARY formate and 0.1 % formic acid. The elution gradient began at 5 % B 0–1 min and CH:CHROMATOGRAPHY_SUMMARY increased linearly to 100 % B by 12 min, held at 100 % B until 14 min, then at 5 CH:CHROMATOGRAPHY_SUMMARY % B for a further 5 min. MS data acquisition was performed in positive and CH:CHROMATOGRAPHY_SUMMARY negative ionisation polarity with mass range 50–1700 in 2 GHz mode with CH:CHROMATOGRAPHY_SUMMARY acquisition rate at 3 spectra/second. Sample injection volume was 1 and 2 µL in CH:CHROMATOGRAPHY_SUMMARY negative and positive polarities, respectively. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 1290 Infinity II CH:COLUMN_NAME Waters Atlantis dC18 (3x100 mm, 3 µm) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Agilent 6550 QTOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS MS acquisition conditions detailed in attached Supplementary Materials. Raw data MS:MS_COMMENTS were mined using the targeted feature extraction function in Masshunter MS:MS_COMMENTS Profinder (build 10.00, Agilent) with mass targets based on chemical formulae of MS:MS_COMMENTS known/predicted phe-tyr pathway metabolites from the customised compound MS:MS_COMMENTS databases described below. A combined compound database was compiled using PCDL MS:MS_COMMENTS Manager (Agilent, build 08.00). Accurate mass retention time (AMRT) matched MS:MS_COMMENTS metabolites were present in our published AMRT database, which was generated MS:MS_COMMENTS from chemical standards using the same LC-QTOF-MS methodology employed here: MS:MS_COMMENTS phenylalanine, phenylethylamine, tyrosine, N-acetyl-tyrosine, tyramine, HPPA, MS:MS_COMMENTS HPLA and HGA. Other established phenylalanine metabolites added to the database MS:MS_COMMENTS for mining by accurate mass alone were hydroxyphenylacetic acid, MS:MS_COMMENTS phenylacetaldehyde, phenylacetamide, phenylacetic acid, phenylacetylglutamine, MS:MS_COMMENTS phenylethylamine, phenyllactic acid and phenylpyruvic acid. The remaining MS:MS_COMMENTS formulae were from non-established but theoretically possible phase 1 and 2 MS:MS_COMMENTS biotransformation products derived from phenylalanine (n=74), tyrosine (n=74), MS:MS_COMMENTS HPPA (n=67) and HPLA (n=67) predicted using the Biotransformation Mass Defects MS:MS_COMMENTS tool (Agilent), in addition to the HGA biotransformation products (n=7) MS:MS_COMMENTS previously established by our group. Feature extraction parameters were accurate MS:MS_COMMENTS mass match window ±5 ppm with addition of matched retention time (RT; window MS:MS_COMMENTS ±0.3 min) for AMRT database metabolites. Allowed ion species were: H+, Na+, and MS:MS_COMMENTS NH4+ in positive polarity, and H− and CHO2- in negative polarity. Charge state MS:MS_COMMENTS range was 1–2, and dimers were allowed. ‘Find by formula’ filters were: MS:MS_COMMENTS score >60 in at least 60 % of samples in at least one sample group. Where MS:MS_COMMENTS compounds were detected in both positive and negative ionisation, the polarity MS:MS_COMMENTS with the clearest signal was selected for further analysis. Extracted peak area MS:MS_COMMENTS intensity data were exported in .csv file format and imported into Mass Profiler MS:MS_COMMENTS Professional (MPP; build 15.1, Agilent), in which all statistical analyses were MS:MS_COMMENTS performed unless stated otherwise. In MPP, all data were log2 transformed and MS:MS_COMMENTS pareto scaled. Urine data were normalised to 24-h creatinine values. QC was MS:MS_COMMENTS performed based on compound signal intensity data from the pooled samples MS:MS_COMMENTS interspersed throughout each analytical sequence. Compounds were retained for MS:MS_COMMENTS subsequent statistical analyses if a) observed in 100 % of replicate injections MS:MS_COMMENTS for at least one sample group pool, and b) peak area coefficient of variation MS:MS_COMMENTS (CV) remained <30% across replicate injections for each sample group pool across MS:MS_COMMENTS batches 1 and 2 combined. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS peak area (pareto-scaled, log2-transformed, 24h creatinine normalised) MS_METABOLITE_DATA_START Samples F01_V1 F01_V4 F01_V6 F02_V1 F02_V4 F02_V6 F03_V1 F03_V4 F03_V6 F04_V1 F04_V4 F04_V6 F05_V1 F05_V4 F05_V6 F06_V1 F06_V4 F06_V6 F07_V1 F07_V4 F07_V6 F08_V1 F08_V4 F08_V6 F09_V1 F09_V4 F09_V6 F10_V1 F10_V4 F10_V6 F11_V1 F11_V4 F11_V6 F12_V1 F12_V4 F12_V6 F13_V1 F13_V4 F13_V6 F14_V1 F14_V4 F14_V6 F15_V1 F15_V4 F15_V6 F16_V1 F16_V4 F16_V6 F17_V1 F17_V4 F17_V6 F18_V1 F18_V4 F18_V6 F20_V1 F20_V4 F20_V6 F21_V1 F21_V4 F21_V6 F23_V1 F23_V4 F23_V6 F24_V1 F24_V4 F24_V6 F25_V1 F25_V4 F25_V6 F26_V1 F26_V4 F26_V6 F29_V1 F29_V4 F29_V6 F31_V1 F31_V4 F31_V6 F32_V1 F32_V4 F32_V6 L01_V1 L01_V4 L01_V6 L03_V1 L03_V4 L03_V6 L06_V1 L06_V4 L06_V6 L07_V1 L07_V4 L07_V6 L08_V1 L08_V4 L08_V6 L09_V1 L09_V4 L09_V6 L10_V1 L10_V4 L10_V6 L11_V1 L11_V4 L11_V6 L12_V1 L12_V4 L12_V6 L13_V1 L13_V4 L13_V6 L14_V1 L14_V4 L14_V6 L15_V1 L15_V4 L15_V6 L16_V1 L16_V4 L16_V6 L17_V1 L17_V4 L17_V6 L18_V1 L18_V4 L18_V6 L21_V1 L21_V4 L21_V6 L22_V1 L22_V4 L22_V6 L23_V1 L23_V4 L23_V6 L24_V1 L24_V4 L24_V6 L28_V1 L28_V4 L28_V6 L29_V1 L29_V4 L29_V6 L30_V1 L30_V4 L30_V6 L31_V1 L31_V4 L31_V6 L33_V1 L33_V4 L33_V6 L35_V1 L35_V4 L35_V6 L37_V1 L37_V4 L37_V6 L38_V1 L38_V4 L38_V6 L40_V1 L40_V4 L40_V6 P01_V1 P01_V4 P01_V6 P02_V1 P02_V4 P02_V6 P03_V1 P03_V4 P03_V6 P05_V1 P05_V4 P05_V6 P06_V1 P06_V4 P06_V6 P07_V1 P07_V4 P07_V6 P09_V1 P09_V4 P09_V6 P11_V1 P11_V4 P11_V6 P12_V1 P12_V4 P12_V6 P13_V1 P13_V4 P13_V6 P15_V1 P15_V4 P15_V6 P16_V1 P16_V4 P16_V6 P17_V1 P17_V4 P17_V6 P18_V1 P18_V4 P18_V6 P20_V1 P20_V4 P20_V6 P21_V1 P21_V4 P21_V6 P22_V1 P22_V4 P22_V6 P23_V1 P23_V4 P23_V6 P24_V1 P24_V4 P24_V6 P26_V1 P26_V4 P26_V6 P28_V1 P28_V4 P28_V6 P29_V1 P29_V4 P29_V6 P30_V1 P30_V4 P30_V6 P31_V1 P31_V4 P31_V6 P32_V1 P32_V4 P32_V6 P33_V1 P33_V4 P33_V6 P34_V1 P34_V4 P34_V6 P35_V1 P35_V4 P35_V6 P37_V1 P37_V4 P37_V6 P39_V1 P39_V4 P39_V6 P40_V1 P40_V4 P40_V6 P41_V1 P41_V4 P41_V6 P42_V1 P42_V4 P42_V6 P43_V1 P43_V4 P43_V6 P44_V1 P44_V4 P44_V6 P46_V1 P46_V4 P46_V6 P47_V1 P47_V4 P47_V6 P48_V1 P48_V4 P48_V6 P49_V1 P49_V4 P49_V6 P50_V1 P50_V4 P50_V6 P52_V1 P52_V4 P52_V6 P55_V1 P55_V4 P55_V6 P60_V1 P60_V4 P60_V6 P61_V1 P61_V4 P61_V6 P62_V1 P62_V4 P62_V6 P63_V1 P63_V4 P63_V6 P64_V1 P64_V4 P64_V6 P65_V1 P65_V4 P65_V6 P63_V1 P63_V4 P63_V6 P64_V1 P64_V4 P64_V6 P65_V1 P65_V4 P65_V6 Factors Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Treated Treatedrial arm:Untreated Treatedrial arm:Untreated Treatedrial arm:Untreated Phenylalanine N-acetylcysteine 0.17472485 2.785885 3.16244 -0.21332519 -0.29267415 0.81904835 -0.7951523 -0.58136535 0.23733962 -0.42368832 2.1397374 -0.13409573 -0.46003547 2.0736625 2.5637782 -1.5197818 -1.2719804 -0.13590118 -0.47644198 -0.5435934 0.20877124 -0.6411354 1.853588 1.7634971 -0.5914222 2.5034723 2.2841341 -0.18153088 0.7432497 0.98313344 -0.863317 2.4733114 2.4422407 -0.44535765 -0.05822792 -0.15095212 -2.2396302 -0.15609705 0.4076311 -1.6529616 -1.4413451 -0.5815135 -0.31125382 2.5977812 3.0140007 -0.55520535 2.0400789 2.9829926 -0.20805101 3.1031566 2.825017 -0.73500645 -1.3442 0.8907142 -0.72764134 2.9642296 2.5468006 -0.76470983 0.040513948 0.15455168 -0.108588904 0.09163194 0.47840425 -0.52114004 2.0977633 2.4935505 -0.43797684 -0.8579001 -0.063306354 -0.7218643 1.6057227 2.292824 -0.8811365 2.6468143 2.2989218 -0.21579303 1.9481566 1.8119861 -0.25322813 1.779059 2.9013894 -1.331248 -0.9225161 -1.1467308 -0.50490224 -0.26528454 -0.94649863 -1.3833367 2.522956 3.0819647 -2.1202612 2.4154415 2.229382 -1.400517 2.284198 2.1987233 -0.49001297 -0.2515849 -0.9765556 -0.92124593 2.7233791 2.2405393 -1.0068867 -1.2587895 -0.21601419 -2.2593815 1.8788061 2.5063012 -1.2957926 -0.9878112 -1.4552377 -0.75445074 1.9175918 2.3282857 -0.8402554 -0.8188964 -0.7398097 -1.6791059 1.6536883 2.4303253 -1.0982981 -1.098324 -1.3296189 -2.768376 2.1374187 2.172374 -2.8235085 -0.52841 -0.6477333 -0.90073913 2.0134642 2.6693244 -1.1406467 -0.7697547 -0.19144173 -1.214304 -1.3239268 -0.15485178 -1.8193469 2.1463091 2.318337 -0.9520875 -1.0401063 -0.7371261 -0.7233864 1.8823012 2.6415443 -0.99738085 -0.12648131 -0.29631698 -0.29485703 2.273503 2.7115774 -1.0499761 -1.7299644 -0.60014886 -2.753577 -0.94676197 -1.794224 -0.08564077 -1.8476238 -0.9741256 -0.2596654 2.0708578 1.9822662 -3.7861164 -0.46545836 -1.3410741 -2.1563897 2.1149426 2.6253757 -2.554628 1.6148355 2.002341 -2.5628421 -0.7122768 -0.21874319 -2.0469158 -1.0873717 -0.24293986 -1.2835004 2.1218903 2.342699 -1.374543 -2.2983453 -1.0102267 -2.6191666 2.0472147 1.8899914 -1.1173838 -0.007251048 -0.29956236 -2.2026992 -0.18196562 -0.7223834 -1.865599 1.8277227 1.7473533 -1.9721351 -0.48424402 -0.84369975 -1.0780989 -1.7739 -0.96972144 -1.8261254 1.9082136 1.8670524 -2.8605278 -2.1194444 -1.8704768 -1.943485 -2.1970994 -1.4949477 -1.5570774 2.0738268 2.537007 -2.6074696 1.9248786 1.8791872 -2.2534232 -1.721454 -1.1985658 -2.027145 2.1054568 2.2723486 -2.2565806 -2.2668598 -1.7377253 -1.0211369 -1.1593755 -1.9814457 -2.1059203 1.800651 0.010766806 -2.0023663 2.2756886 2.2995057 -1.828744 -0.8188407 0.5098033 -1.8267456 -1.0107934 -1.1349237 -1.3478147 1.4002228 1.4393363 -1.1844666 -0.98644966 -1.3844268 -2.5708983 -1.438191 1.0266235 -2.8355868 2.0393565 2.565695 -0.8007569 1.83E-04 -0.7903545 -2.6859794 -0.96288186 -0.6598935 -0.07432406 0.42463404 1.0098433 -1.6078835 2.3208957 2.0026174 -1.342136 2.0334406 1.9178255 -1.2778282 1.6188271 3.256642 -1.2699159 2.280464 2.471745 -1.1183246 0.17761391 2.8774798 -1.0355221 -1.0158978 -0.18289945 -1.6910158 -0.5217321 -0.051620327 -2.3712323 2.138698 2.4499328 -1.4046308 2.1818695 2.127337 -0.80770564 2.166958 2.3685431 -1.5847212 -0.7912397 -1.8286711 -1.105315 1.8035233 1.9314035 -1.1172736 -0.27283838 -0.91148865 -0.16411594 2.4666498 2.7633166 -0.07940249 -1.8440859 -0.50665414 -1.1172736 -0.27283838 -0.91148865 -0.16411594 2.4666498 2.7633166 -0.07940249 -1.8440859 -0.50665414 O-Methyl-phenylalanine -0.32286927 2.7383566 2.6667795 0.12196792 -0.49585965 0.55520725 -0.3074548 -1.6423736 -0.62630934 0.8853168 2.2233477 -0.17636564 0.27783883 1.5844793 1.9441684 -0.5281938 -0.94385177 -0.66544604 -2.1680129 -3.3020585 -0.211075 -0.3065522 2.29914 2.3839037 0.20691499 1.9067512 1.6339391 -0.71796024 1.482825 0.9847348 -3.194978 1.5084046 0.70729285 -0.589465 -0.5229062 -3.250181 -1.4744302 0.033909813 0.57776433 -0.30925262 -1.2942653 -0.9656005 0.8171948 3.561594 4.5966773 0.50471556 2.085192 3.1510658 0.986454 3.075445 2.0213592 -1.065593 -1.7585139 0.007414532 -0.27490604 4.006635 3.0287664 -0.7692327 0.58237934 -1.6515727 -0.7194858 -1.0476278 0.75229317 -1.1572001 2.0253525 2.051231 -0.1886708 -1.3562894 -0.33156314 0.36285365 1.5386049 2.0191433 -1.8840183 2.3811145 2.1264646 1.2145932 1.1149122 1.2796725 -1.8716568 1.5374506 2.6094956 0.1778551 -0.16471823 -1.058097 -0.09841653 0.93098795 -0.03820705 -0.78535956 0.91467595 1.3368715 -1.1346216 1.1168268 1.7997553 0.51350474 1.5203983 1.6368707 0.575956 -1.906037 -0.20609894 0.56749535 2.5931644 0.9707696 -2.0937068 -0.90938985 0.709239 -2.1028872 -0.014639431 1.9626843 -1.0157101 -1.2461363 -1.2126436 0.4416476 0.67950714 1.9820179 0.58885765 0.1961924 0.46785358 -0.2975454 1.455233 1.3971177 0.085362226 -0.35566294 0.29103464 -1.5331295 2.0820332 2.3686504 -1.3616023 -1.0342014 -1.2690692 0.20701608 2.0218935 1.8468877 -0.20931818 0.235986 0.41798174 1.2912568 -1.0419904 1.1378614 -0.11537656 2.788256 3.2785063 -1.3218215 -1.6469256 -0.76615584 0.4620979 1.7036892 2.8833363 0.48657727 -0.43304172 -0.57221055 0.94884884 2.217493 2.4429665 -1.8040612 -3.509816 -1.4163995 -0.8296882 -1.490626 -3.6624763 0.8288126 -0.9310853 -0.4617776 0.23152903 2.1688504 1.8179437 -0.5562423 -0.47242588 -0.8557273 -3.4647017 1.1932306 1.3360732 -3.8532372 0.95912385 1.6395365 -1.3257754 -1.6214879 0.54385597 -3.7194548 -2.5151272 -0.5577366 -1.5888067 2.5024416 1.7961881 0.57339907 -0.65922827 -0.753706 -1.7284507 1.7044672 1.8025725 -0.34430254 0.5812606 -0.33754802 -3.4647017 -1.468859 -2.0439408 -3.882246 -0.06549446 0.576657 -0.30273816 -0.6484196 -1.1416483 -2.0646682 -1.4601817 0.12954019 -1.241261 1.7619361 1.7703893 -0.44516295 -1.7769582 -0.23584875 -1.0976831 -0.6116249 -1.3433356 -0.86155957 1.2715303 2.078278 -2.0978198 1.0805422 0.6248845 -0.33413374 -2.2833607 -0.15019496 -3.1151562 0.94665414 1.5172662 -1.793873 -2.5778348 -2.809333 -3.5185618 -3.290797 -0.5475914 -0.56024224 0.84870255 -0.16491754 -3.50098 2.1398602 2.782843 -3.445973 -1.8988665 -0.39252803 -1.2195898 -0.9299247 -0.37460673 -0.26803592 1.3758479 1.9050297 -1.6481231 -0.8410121 -1.0475937 -2.0804873 -1.2523504 -0.2818405 -1.0266272 0.68109596 0.57601064 0.18061191 0.67418087 -0.5049584 -1.2112547 -2.0809627 -3.445973 0.033479292 0.44000524 0.97582304 -0.1804385 2.9182706 2.275708 -0.3994588 2.349634 2.0356588 0.022815917 0.30373728 2.7016518 -1.7686783 1.9534166 2.3319616 -0.37379038 -0.16398075 1.9695338 -0.73043966 -0.27968162 0.7705382 -0.9700173 -1.5265417 -1.6069683 -1.4196745 1.5344118 1.7940013 -0.17959683 2.8515985 2.2054083 -3.52722 -0.26456013 0.7532493 -1.3587674 -0.40495706 -1.1828127 -2.6093419 1.3461413 1.7688905 -1.4620006 -1.0917933 -2.1743898 -1.2816269 2.6588302 2.9579263 0.654173 -3.4830317 -0.1153982 -1.4620006 -1.0917933 -2.1743898 -1.2816269 2.6588302 2.9579263 0.654173 -3.4830317 -0.1153982 Phenyllactic acid 0.19785361 2.6583734 2.5657578 0.06918559 0.14231008 -0.17350319 -0.7761929 -0.42199227 0.23464501 0.010664406 1.9593012 -0.31662253 -0.18727891 2.509953 2.7774467 -1.4061508 -0.77482826 -0.08473119 -0.44351822 -0.8580697 -0.13019742 -0.8175225 1.3674773 1.862605 -0.6841222 2.3236256 2.067554 0.030945942 0.7891179 1.0846038 -0.53985614 2.142731 1.1482936 0.021716963 0.54394513 -0.49605724 -0.9942389 -0.028110482 0.68568766 -0.83592063 -1.5892956 -0.2772227 0.12509836 1.3268203 3.3330286 -0.14630389 0.7650842 2.3876045 0.3823068 3.525443 2.414038 -0.29516676 -1.1575642 0.7709809 0.5001804 3.61604 3.266667 -0.2753399 -0.053714454 0.37715465 -0.47393137 1.0188341 1.1649207 -0.53738135 2.504199 2.6665647 -0.33693457 0.23207687 -0.35895425 -0.41793317 1.5728217 2.3499794 -1.3596826 2.3683496 2.272691 -0.14110228 1.9197378 2.3710728 -0.19246037 1.59682 3.0458755 -0.68046343 -0.23160265 -0.8069399 0.38853922 0.27393684 0.29628545 -1.0666536 1.1187295 1.9822057 -1.7802217 1.0610975 2.0181868 -0.26192853 1.8312343 1.6337566 -0.009348596 0.5790924 -0.091600135 -0.3278356 2.4614937 1.2760541 -1.0649698 -0.9875024 -0.44050395 -1.2818215 0.7567841 2.0346308 -0.6726815 -0.8062771 -0.848513 -1.1196357 0.9147692 2.0884142 -0.28728288 -0.5284984 -0.18151584 -1.7591864 1.9569442 1.6950871 -0.17988938 -0.6648611 -0.7649908 -1.1870136 1.5684996 2.0820243 -1.2840863 -0.058572456 -0.24997517 -1.3781344 1.389486 1.2713902 -0.5270825 -0.7042109 -0.49399868 -0.5743076 -2.5080976 -0.97545874 -1.5517492 2.0577319 2.4162827 -0.7047217 -1.3429792 -1.0720048 -0.5601596 2.3878 2.408909 -0.84679747 -0.67780805 -0.6309967 -0.05621425 2.1804402 2.7772284 -0.26967144 -0.8254052 -0.20879814 -0.5269336 -1.529339 -1.7347579 -0.101918496 -2.05046 -1.5869124 0.38218722 1.6872362 1.5448858 -1.9589851 -0.063658096 -1.2580087 -0.9594902 0.48432785 1.1422089 -2.486183 1.8533126 0.95051813 -1.0938773 -0.54433084 0.40670606 -1.7147931 -1.7947578 -0.8300703 -1.9427853 0.2767918 1.056735 -1.5555612 -1.965976 -1.709492 -2.0740018 0.82889485 1.6003256 -0.9267701 -0.28964356 -0.9040724 -0.904463 -0.8090308 -0.1972903 -1.8283818 0.29453084 0.80568266 -1.2776641 -0.61609495 -1.5856173 -1.3162236 -1.6963601 -1.096725 -1.5667608 1.5501503 1.4258196 -1.6502031 -1.7595129 -1.2781347 -1.7927694 -1.0859795 -1.0542231 -1.1403903 1.1753947 1.5738837 -1.5572896 1.6794219 1.0190477 -1.6927997 -1.756141 -0.87381244 -1.4698236 1.2005831 1.6843336 -1.5422834 -1.7781789 -1.3471011 -0.70712143 -1.3403121 -1.3053071 -1.3667912 1.1200489 -0.9619015 -0.9279541 1.6874009 2.5264616 -1.7328379 -1.3035678 -0.2833367 -1.2904017 -0.84664667 -1.6230251 -1.1032156 1.0408281 0.90475285 -0.07632307 -0.1634625 -0.65761256 -2.8892643 -1.9860122 -0.008937864 -1.9313664 0.742088 0.98216105 -0.25202456 -0.15360554 -0.8212942 -1.1687058 -1.1580842 -0.028587738 0.2977923 0.894927 1.7146984 -0.5814042 0.90534484 0.7902652 -0.15907566 2.1453087 2.066204 -0.9572687 0.71271425 3.1909895 -0.30693522 2.4120703 2.7577584 -0.5740873 -0.9739916 2.2614675 -0.96863437 -0.43453884 0.49512714 -2.0736175 -2.5975726 -1.3833891 -1.3157048 1.4869658 2.0612593 -1.5793446 1.5695529 0.8924761 -1.3735058 1.1241074 1.996172 -0.9840408 -0.1534316 -1.2266624 -0.7193879 0.3453738 1.7081182 -1.0626256 -0.69370395 -1.4753432 0.05505651 1.6321467 2.5642197 0.054098945 -1.9259025 -0.72182727 -1.0626256 -0.69370395 -1.4753432 0.05505651 1.6321467 2.5642197 0.054098945 -1.9259025 -0.72182727 Tyrosine -0.6239922 1.986868 1.9875165 -0.14962272 -0.020906396 1.0333515 -0.78808194 -1.0777038 -0.6766957 0.3924816 2.032037 -0.1768572 0.27217597 2.4234936 2.9810777 -1.6177515 -2.4393785 -0.8769445 -0.5875458 -0.53941727 0.6426652 -0.19098896 1.605237 1.4976736 0.7469079 2.891894 2.628567 -1.5766253 -0.63050544 -0.05555753 -1.981648 0.9524959 0.2649962 -0.12221155 0.1837613 -0.5281719 -0.60155135 -0.15397757 0.4608241 -1.3840528 -2.0393481 -0.7418761 0.24001324 1.6323342 3.0524898 0.21823186 1.010769 2.2473204 -0.16923477 2.6415844 1.6173444 -1.3553511 -2.1388328 -0.12669519 0.2282767 3.5354092 3.2067158 0.28354624 0.8735028 0.9022439 -0.18810256 -0.8518172 0.017135298 0.22657657 2.5435863 2.5791059 -0.4001474 -0.67145616 -0.24579318 -0.38197017 0.74412054 1.8950802 -0.20122989 3.529063 2.9278202 0.045227945 1.4625591 1.944342 -1.5599087 -0.06666632 1.6201816 -0.87689143 -0.68461 -0.5408009 -0.26445386 -0.25783843 -0.6203797 -1.0193079 -0.42987353 1.4591964 -1.2952076 1.4650418 1.9977963 0.2171129 1.9716581 1.9204315 -0.47494355 -0.71804965 -1.0463773 0.0748434 3.0922651 1.6846806 -1.1020216 -0.9659235 0.1857766 -1.4259497 0.61248934 1.3709306 -1.1196868 -0.60341394 -0.42623574 0.08108994 1.1776655 1.9265926 0.35419527 -0.10913664 0.24585596 -0.8547612 1.3439277 1.5600473 -0.56208396 -0.85074353 -0.4351681 -1.7346445 0.6283471 1.2302097 -1.5559797 -1.6661783 -1.1899774 -0.60176885 1.2781099 1.7019355 -1.0235041 -1.0416516 -0.8884487 0.31789514 -0.7097205 0.28957728 -0.253536 2.3448641 2.1962698 -0.98975253 -1.4007409 -1.1638974 0.015263663 1.5773307 2.1427639 -0.40466082 -0.76961994 -0.5005672 0.8549651 1.5373055 2.3299143 -0.27622536 -0.6377531 -0.11035722 -0.60740703 -1.2629374 -1.533258 -0.23150611 -1.0501491 -0.7832165 -0.9864351 1.4330479 1.1076772 -1.4932444 -1.654777 -1.7947122 -1.4772869 0.39146554 1.0155438 -1.7800899 0.8149333 1.1234592 -1.2197572 -1.2638758 -0.18424991 -1.3646789 -1.754129 -1.1868204 -1.7715576 0.6099284 0.7082909 0.6341445 -0.27207568 -0.032331005 -1.2917038 1.229481 1.4683293 -0.31328076 0.1778901 -0.44929725 -1.0502254 -1.1673443 -0.5564056 -1.175887 0.7504745 0.8681882 -0.10351527 -1.1848763 -1.5905914 -0.6598665 -0.5178456 -0.29162428 -1.4237705 1.4032726 1.1680355 -1.3783175 -0.85893226 -0.41992965 -1.5580242 -0.84233993 -1.2610736 -0.56325793 1.3980525 2.1028278 -0.5073289 1.5123101 1.1009233 -0.020048887 -0.81519216 0.2626709 -0.73641527 0.955258 1.3362871 -0.5314945 -1.1051668 -1.277075 -1.0544624 -1.1194681 -0.6201603 -1.3162596 1.3173314 0.74407524 -1.2785875 1.2892594 1.7731353 -1.2343316 -0.8016817 0.002946595 -0.5144796 -0.88260275 -1.2385143 -0.52073973 0.4195284 0.5840744 -0.50439656 -0.60143876 -1.0179048 -0.5112437 -0.1036434 0.65380186 -0.6126984 0.9549124 1.5863097 -0.5206129 0.34507462 -0.56109893 -0.9130181 -1.2282592 -0.6861743 -0.26371092 0.34637284 1.1612544 -0.6303805 1.8736548 0.951718 -0.83672506 1.8094329 1.5432931 -1.1715012 0.035168875 2.3056712 -0.33670792 2.3373764 2.514629 -0.016592316 0.8922256 3.403437 -1.8313683 -1.4919474 -0.90572315 -1.1267612 -1.0736629 -0.104048535 -1.1739746 1.5081178 1.6646465 -0.62958187 1.2973764 0.76233274 -0.88683206 1.127706 1.5898937 -0.8814618 -0.85891414 -0.87505084 -1.2431138 0.5597567 0.98473954 -0.63367724 -1.2625899 -1.5675001 -1.5153234 0.6671984 0.9979484 -0.8805635 -1.769418 -1.4614486 -0.63367724 -1.2625899 -1.5675001 -1.5153234 0.6671984 0.9979484 -0.8805635 -1.769418 -1.4614486 N-Acetyl-tyrosine 0.033034347 2.7336977 2.8950183 -0.61893475 -0.7707927 0.2336305 -1.0325943 -1.2751961 -0.81476575 0.3002599 2.214348 -0.08743676 -0.22430925 1.719449 2.024142 -0.27580535 -0.8308565 -0.32578275 -1.3014315 -1.4792292 -0.06707461 -0.32707623 2.2686992 2.77528 0.11209919 1.9536558 1.819704 -1.9905591 -1.1313018 -0.3747744 -1.9198171 1.5451472 0.9652275 -0.9404345 -0.051887605 -1.0408276 -0.6231906 -0.6724456 0.61021525 -1.3579658 -2.4177887 -0.48339272 1.0393932 3.4084847 4.6849895 0.58397 2.299206 3.3652866 -0.10683455 3.2100697 2.0012817 -0.34374267 -0.5809788 0.73819953 -0.01115639 4.3144345 3.3524072 -0.6824136 -0.49953136 0.26028803 -0.3249004 -0.97212684 -0.067965046 -0.62578046 2.3845038 2.247302 -1.3452018 -1.4372461 -0.8580222 -0.3244875 1.7029154 2.3784094 -0.99692154 2.416072 2.2118177 -0.52328086 0.78184575 1.1291155 -1.069974 1.8504835 2.7180972 -1.4064049 -1.487455 -0.975632 -0.21620297 -0.6592733 -0.44141823 -1.0133616 0.9567793 1.3180362 -1.2097319 1.1035991 1.7072775 -0.19443646 1.4796641 1.2938675 0.96375036 0.007718235 0.5330802 -1.0982236 2.2783055 1.2197583 -1.8015033 -1.5444276 -1.2045562 -1.4364902 0.34598145 1.6318252 -0.46921915 -0.39443147 -0.10201109 -0.16598594 0.53564644 2.1444151 3.46E-05 -0.3806015 -0.016183116 -0.541097 1.558976 1.2531097 -0.34131274 -0.8174417 -0.07041864 -1.3999189 2.3267586 2.6962416 -0.839341 -1.6767169 -0.9970601 -1.2597041 2.2127047 2.0471108 -1.1353335 -1.0554585 -0.8476696 0.30019578 -1.1934923 0.12981834 -0.1986842 2.7394478 3.0524101 -0.84316665 -1.0737545 -0.79334456 -0.66574425 1.8028436 2.642326 -0.6078361 -0.64206463 -0.45644704 0.047920503 2.3939867 2.766446 -1.443747 -2.121433 -0.78108585 -0.9969308 -1.5228137 -1.2663033 -0.59729415 -1.0024471 -0.625311 -0.6797313 2.0539906 2.0402045 -1.5920699 -1.4016588 -1.405779 -1.8804567 1.1516327 1.5652206 -2.6159377 1.1576232 1.6693689 -0.7285913 -1.052685 0.65392953 -1.5159765 -1.6285204 -1.4650614 -1.0164325 2.488406 1.8929816 0.6319852 -0.11344812 -0.48583418 -1.5690428 1.6261545 2.0061648 -0.12199731 0.053610723 -0.43296665 -1.0631987 -1.2374307 -0.6394724 -1.7486439 -0.17798021 0.70782787 -1.4332945 -2.4433491 -1.9207295 -1.2522845 -1.3686892 -0.4983216 -1.0158498 1.9811218 1.9964751 -0.088025756 -0.6074654 0.057666175 -1.4623255 -0.68038267 -0.66843516 -1.1445577 1.5667115 2.1288598 -1.5910593 1.2144088 0.8711327 -0.21600547 -0.7203898 -0.25665873 -1.8316938 0.7950371 1.6150179 -1.1858884 -1.0599084 -1.566181 -1.21564 -0.9442792 -0.9401683 -2.2078784 0.5732698 -1.4534084 -1.5428085 2.2196457 3.1110365 -1.5592266 -1.3903518 -0.8178673 -1.8065007 -1.8091234 -2.4243076 0.004161125 1.6810957 2.0256364 -0.8035135 -0.7092507 -1.1571474 -2.3190293 -1.2889811 -0.7240404 -1.2158628 0.75684553 1.0794442 -0.25032234 0.71477693 -0.15296611 -1.7012061 -1.5843413 -0.7010919 -0.583314 0.32337302 0.52082205 -0.6582016 2.9358199 2.5912585 -0.85378134 2.2755198 2.1534765 -1.5996581 0.36429825 2.9145951 -0.8171414 1.9543442 2.1141427 -1.7205462 -1.5267161 1.8440356 -0.51119477 -0.45584014 0.7567901 -1.5707595 -1.4185418 -0.71018964 -1.688997 1.5398254 2.0237875 0.015967727 2.717164 2.1737924 -2.024157 0.36732468 0.9054819 -1.0851125 -1.4811435 -1.1016241 -1.322028 1.2511382 2.0135493 -0.43243828 -1.2139976 -1.1388687 -0.34378022 2.7029285 3.1911292 -1.1406577 -1.947174 -1.8697912 -0.43243828 -1.2139976 -1.1388687 -0.34378022 2.7029285 3.1911292 -1.1406577 -1.947174 -1.8697912 Tyrosine-sulfate 0.30063385 1.7400807 1.6473886 0.44432887 0.112061016 1.1639843 0.015455253 -0.53654236 -0.13906658 1.0499117 0.58493227 0.04024538 0.21778359 1.3783975 1.7253286 0.05481021 -0.7360979 1.5056279 -0.2976831 -0.067520194 0.90066 -0.29487798 -0.24923496 0.17722093 0.019724717 1.6902533 1.4063478 -0.73471147 0.023239171 0.93777984 -0.3331213 1.0626224 0.27628538 0.81714207 0.9692375 0.748907 -0.31368157 0.56656873 1.0502053 -0.74045 -1.1390201 0.37862024 0.76237833 1.0294815 2.6177905 0.45483682 -0.17703591 1.3921341 0.9518038 2.6151264 1.2193613 0.23613684 -0.5721168 1.9189054 0.75183576 2.7708426 2.0978875 -0.26992804 0.7241358 1.2293828 -0.057779863 -0.22851117 0.5417085 0.7085247 1.3409572 1.309442 0.28643826 -0.81059974 0.15289687 -0.27798358 -0.18017483 0.5935853 0.033303075 2.0681689 1.5285947 0.49462715 0.6917791 0.80369836 -0.41856566 0.09606096 1.9114703 -0.0689688 -0.3458974 -0.12298621 0.36609763 0.54424363 0.077491194 0.1542447 0.4325747 1.0697136 -0.75000846 0.57688457 1.0657244 0.52755 1.321116 1.1751527 0.44455642 0.04985502 0.14892657 0.14388478 1.7817283 0.41536456 -1.263799 -0.72598124 0.54502463 -0.20700088 -0.14703235 0.9824191 -0.88808304 -0.13665196 -0.40786564 0.29117066 0.020387614 0.8556956 0.29295385 -0.1133073 0.17116904 -0.33070195 0.4089143 0.68240166 -0.07796593 -0.7308632 -0.15985413 -0.69145864 0.3046498 0.44942108 -0.51345044 -0.58773184 -0.4298475 0.17253341 -0.29565582 0.27790642 -0.2749769 -0.61626554 -0.21043976 0.51206714 -0.47640932 1.0044591 -0.11754605 0.90429884 1.1305261 0.61654973 -0.27293706 0.2301873 0.15161832 0.19854935 1.6063851 -0.04480378 -0.25066468 0.112769574 1.2207886 0.742123 1.2289056 -1.048778 -1.0878739 -0.19970429 -0.06803508 -0.40540537 -1.0608479 0.2112538 -0.85326445 -0.5681646 -0.690358 0.23834676 -0.27016422 -1.111976 -0.7066273 -0.97115535 -0.9422658 -0.0385598 0.43314624 -1.5157131 -0.43708348 -0.019816043 -0.9010135 -0.99969614 0.45919526 -0.8211691 -0.7370214 -0.25450113 -1.2132716 -0.11747047 0.47394747 -0.08401073 -1.2194952 -0.27434552 -0.9624424 0.54088193 0.51834893 -0.42426407 0.51918894 -0.23215237 -0.76992214 -0.5435414 9.86E-04 -1.5514638 -0.5039518 -0.43271482 -1.0004157 -0.83717465 -1.178805 -0.7864662 -0.7437487 0.12448285 -0.821647 0.33071926 0.15319762 -1.2202628 -0.49577975 -0.45008004 -1.9854391 -0.9788062 -1.3385937 -0.35281295 0.076262236 0.66277456 -0.6671314 0.025440428 -0.28547618 -0.40139806 -1.0723722 0.19343354 -1.0429167 0.08074033 0.27491236 -0.79013574 -1.3154026 -1.4800041 -0.7630782 -0.8627245 -0.4390147 -0.6294235 0.5363141 0.18037322 0.47774297 1.0716913 1.5264076 -0.92083895 -0.26915413 0.8432919 -0.73522 -0.8243017 -0.9661151 -0.27937785 -0.67550427 -0.55509794 0.00507171 -0.09474777 -0.39531863 -0.84408 -0.48967984 0.95844066 -0.72372484 -0.22608553 0.034054935 -0.064671785 0.18353891 -0.02444451 -0.32890615 -0.48167625 -0.15822445 0.09050585 0.5579259 1.3887329 -0.59067476 0.7369513 -0.16595325 -0.44195914 0.7778352 0.38725758 -0.06185093 -0.678718 2.0327568 -0.5763327 1.1994185 1.458071 0.082208626 -0.13508841 1.5712358 -0.72507423 0.053737927 0.29960328 -0.45467386 -0.011613287 1.0724604 -0.7319906 0.7750828 0.803337 0.19002852 0.8237301 0.21919204 -0.67464846 -0.032685842 0.2886167 -0.9368343 -0.77102196 -0.45517614 -0.42915705 -0.59117544 -0.042788323 0.48653698 -0.17069036 -0.21200016 -0.2842063 0.6596097 1.036768 -0.20334472 -1.0706977 -0.75376934 0.48653698 -0.17069036 -0.21200016 -0.2842063 0.6596097 1.036768 -0.20334472 -1.0706977 -0.75376934 HPPA -1.4381306 3.5037386 3.6750417 -1.2148069 -0.44575545 1.8797653 -0.14920692 -1.1094654 -0.55829525 0.13633037 3.01064 0.097905606 -0.12927419 3.099355 3.4211044 -1.7083036 -2.1790009 -1.1840918 -1.9556205 -2.1031697 -0.562086 -0.66004825 2.6807528 2.9715059 -0.08780062 3.1952462 3.3845851 -1.5184116 -1.3110747 -0.61536413 -1.5667212 3.2960513 3.309121 -1.515862 -1.5416821 -1.4953215 -2.0025244 -1.9010838 -0.9606879 -0.5358137 -1.643661 -0.5374658 -1.1926562 2.5979025 3.906694 -0.8920183 2.268993 3.6264832 -0.69912124 3.9650378 3.320513 -1.7508167 -2.5469172 -0.8654165 -1.3839434 3.8649766 3.5178325 -1.4189607 -1.60068 -0.82599086 -0.17640725 -1.943118 -1.4944153 -1.3093158 3.0634956 3.541855 -1.8175887 -2.3283098 -1.5955065 -1.3473239 2.2691262 3.061936 -1.9841268 3.5885026 3.416522 -1.1043451 2.9919312 3.2346234 -1.9530638 2.3743043 3.516904 -0.75705105 0.14000994 -0.21513498 -1.1726838 -0.8025172 -1.0495147 -1.2680167 2.7753677 3.2466242 -1.758866 3.0119224 3.2754428 -0.12748344 3.2949753 3.1987598 -1.1760647 -1.0676287 -1.5592718 -1.7194059 3.6936605 3.2240856 -1.8470633 -1.599449 -1.4483916 -1.9818927 2.8094616 3.2809248 -1.4819655 -1.0436711 -1.3753625 -0.7837671 2.6675446 3.281162 -1.366801 -1.5301722 -1.4831791 -0.67183846 2.8923085 3.1926718 -1.36608 -1.7319987 -1.4610441 -2.0668533 3.022196 3.189745 -1.8692728 -1.7633829 -1.3780382 -1.7771016 3.0945086 3.3949049 -1.7213314 -1.5352446 -1.3444176 -0.4772204 -1.2183871 -0.4195939 -1.6085519 3.2162697 3.261945 -1.6784332 -1.6237636 -1.4959004 -1.2954315 2.9302263 3.3255296 -1.3339381 -1.2979807 -1.1827147 -1.2449253 3.266217 3.5768192 -1.9970322 -0.8368622 -0.60388386 -1.6697266 -1.9303273 -1.68841 -1.4086404 -1.9017974 -0.7220461 -1.9651997 2.8025968 2.8954926 -2.7005408 -2.176778 -2.307541 -1.4612237 2.946344 3.405279 -2.5818417 1.9283552 2.752381 -0.97817206 -1.6248289 -0.58345985 -0.49781832 -1.671214 -0.9139576 -2.4630513 1.8874409 2.9153144 -0.28524697 -1.3025831 -1.148833 -1.3215668 2.8768787 3.0188534 -0.87368584 -2.044762 -1.703055 -0.69607025 -1.646824 -1.0319973 -1.2470634 2.5241106 2.6137977 -0.83331823 -1.3817766 -1.2724752 -0.5165658 -0.9534787 -1.0399145 -2.2310994 2.7701776 2.8538222 -1.0412627 -0.76915824 -1.0582954 -2.058417 -1.6628 -1.668768 -2.2017248 2.2950954 2.6044927 -0.5528258 2.8987157 2.9810176 -0.71109587 -1.3133703 -0.9283773 -2.2895179 2.821085 3.077535 -1.9558886 -2.0188742 -2.1266205 -1.9443063 -1.908609 -1.999537 -2.189499 2.7217352 1.7265353 -2.0816274 2.8012576 3.1221266 -2.022352 -1.7219739 -1.3211335 -1.8711878 -1.7267035 -2.3397377 -2.142907 2.4604657 2.503047 -0.4657501 -0.9688718 -1.3593224 -2.9999564 -2.2163095 -1.3353615 -1.9639077 2.2485867 2.7012541 -1.9273735 1.0422331 -0.74978 -2.3115766 -1.7096056 -1.2985587 -1.7588454 -1.5617819 -0.65522397 -1.9034553 2.347763 2.358558 -2.3610249 3.0410058 2.8256664 -2.526506 2.7855403 3.847954 -1.6579286 3.1482484 3.1679482 -2.0411272 1.8650217 3.1590774 -2.031466 -1.9610555 -1.4426235 -2.0464616 -2.188651 -1.5646698 -1.9736731 3.0107436 3.0622838 -1.3223219 2.9346604 2.7582624 -2.0296597 2.9127915 3.0742044 -0.83203137 -1.17258 -1.7750162 -3.0701704 2.4182873 3.0662708 -1.6772941 -2.0666323 -1.991312 -1.3155904 3.3261793 3.496049 -1.9764198 -2.3118682 -2.2083979 -1.6772941 -2.0666323 -1.991312 -1.3155904 3.3261793 3.496049 -1.9764198 -2.3118682 -2.2083979 HPPA-sulfate 2.0650928 2.3131778 2.5675986 0.9730388 1.3550266 0.67839926 -1.3114604 0.77745634 0.2384849 -1.1456409 -0.41778448 1.5432761 -1.7007097 2.1307251 -0.5712616 -0.4425053 -0.28780356 1.0261762 0.8489628 1.3951173 1.6529183 0.5741204 0.064849466 0.82388467 -0.582239 2.223041 2.4648983 1.2295476 1.4557339 0.7959387 0.17159244 2.8797693 1.8610382 -1.2393532 1.5836776 0.7671982 -1.4221013 0.101492204 0.46300232 -0.95956904 -1.6138694 0.7969399 0.42664996 -1.7016382 1.8244175 0.66618055 0.7602566 2.583126 0.85817724 2.9496708 1.5743557 0.19238305 -0.6331776 1.7655456 1.3681674 1.0901005 3.365304 1.5471908 1.5303909 1.8272363 1.0635272 1.1369157 0.5175833 -0.25355408 2.0496747 2.4008873 0.0343615 0.4028164 1.503168 1.1296896 2.9146054 2.0024607 0.010421063 1.8686991 3.15824 0.52303946 0.23463842 3.2049787 1.0477486 0.6799729 3.7536461 0.44645867 0.044776767 -0.7631521 0.39752442 1.2173971 0.7973681 -1.0382868 -0.51322687 -0.32677966 -1.5216053 -0.17174439 2.357109 -2.125269 -1.1391796 -0.8231442 0.68028647 1.6547264 0.3790717 0.21968257 2.3779268 -0.009679323 -0.51115423 -0.17042832 0.41874385 -0.27907136 -0.019587863 -0.8436573 -2.5088181 -1.8194898 -0.21547422 -0.4932688 -1.1188751 0.8261504 -0.21990728 -0.27401438 0.25062317 -0.60953784 1.9950356 -0.045949902 0.7721251 -0.7581898 -0.63972574 -2.1458898 0.2852667 0.9539326 -0.71370983 0.18949336 0.026730333 -0.3462993 1.600636 0.88803166 -0.8719986 -1.0263642 -0.12994361 -0.29947436 -2.3191683 -0.28040546 -0.59387696 -0.60102135 -0.39622766 1.1104616 -0.28676242 -0.0232193 -0.42705238 0.8736849 0.10206653 -0.45442724 0.36877364 0.80868995 0.37395874 1.712953 1.8714586 0.68464416 -1.0895873 1.0246515 -2.4922101 -2.1394987 -0.6078631 0.64033616 0.87456703 -0.79832554 2.0451238 0.054521766 1.022624 -0.9973424 -0.44181314 -0.8699086 -2.0280838 0.00850297 1.336042 -2.978663 -1.0524932 -1.5429264 -1.321217 -0.3777022 -1.2276663 -1.7793908 0.26791885 -0.5821817 -0.22337389 -0.49007326 1.8527323 0.64632547 0.23956533 1.0361472 0.9279002 -0.54864496 1.8423827 0.6315035 -0.7992772 -0.7662562 -0.8109589 -0.5067418 1.072902 -1.4141386 -2.8689582 -1.0148866 -1.0983182 -0.41140887 -0.11420223 -1.7309208 -2.1271312 -1.8451539 -1.435497 -0.07299058 -0.102159895 -1.7863935 -2.8299596 -0.98489827 -0.46205196 -1.189003 -0.05403049 -0.85838264 0.56643516 -0.10056438 -0.8237211 1.0380924 2.0049977 -2.621125 -0.56440693 -0.75622016 -1.8688278 -1.0995641 -1.0687805 -2.2029934 -2.7216249 -0.732319 -2.2847805 -1.6888187 -0.9466182 -1.511125 -0.6035917 -0.47596216 -2.1032107 -1.5784707 0.20787461 -1.2436683 -1.6948769 -0.6166301 -2.1613007 -1.3105364 -1.611408 -0.62749094 0.38599205 -0.27845 -0.57991844 -0.2638026 -0.44883457 -3.1668377 -0.18781543 -0.28766575 -1.6015528 0.19460763 -0.015291308 -0.22666278 0.3670854 1.1394874 -2.5212 0.5566161 1.2897856 0.9857424 0.5370327 0.85344225 0.93318444 -0.057224095 0.6354891 -0.45218915 1.8295633 1.63293 0.45175967 1.5650543 1.4256947 0.7491614 1.197902 1.7777677 -0.1641641 -0.51039773 0.57521755 0.029671537 -0.7408844 0.74388486 -1.7854187 -1.6321844 -0.6850646 -1.6138353 -0.75209683 1.2344416 0.56964165 1.0462464 -0.20755975 -1.2654107 0.45380524 2.400242 -1.3301146 -0.6998029 -1.4699429 0.48801222 -1.6227735 0.04318125 0.9880513 1.7441949 0.94523257 0.7517369 0.16614142 2.1525974 -0.18617356 0.059983082 -0.46126515 0.9880513 1.7441949 0.94523257 0.7517369 0.16614142 2.1525974 -0.18617356 0.059983082 -0.46126515 HPLA 8.49E-04 2.7249959 3.2157269 -0.2391437 -0.5500997 0.61544985 -0.99675995 -0.6154733 0.20228502 -0.6606533 2.1912458 -0.14567252 -0.5621138 2.4792042 2.7070296 -1.5196958 -1.8046929 -0.5564986 -0.5038891 -0.86847395 -0.65921557 -0.74952555 1.9185292 2.0192645 -0.79313314 2.8389125 2.5878549 0.08380499 -0.19444226 0.9288221 -1.3754395 2.6562324 2.4424272 -0.95973086 -0.21356854 -0.7981851 -1.8482668 -0.59073794 0.009818235 -1.3803813 -1.9446833 -0.9070714 0.011446783 2.5282178 3.1990986 -0.5036585 2.2126272 3.262018 -0.28769714 3.49607 2.9065607 -0.3603594 -1.5831592 0.6528952 -0.6394597 3.2403388 2.970368 -0.603052 -0.039735176 -0.1376563 0.107215896 0.05883798 0.23977634 -0.8728137 2.434874 2.7504117 -0.31560186 -0.85414356 -0.42446262 -0.5032034 2.0398376 2.6805544 -1.163473 2.7085145 2.5641346 -0.7471929 2.0991695 2.236233 0.22776732 2.1241672 3.3108 -1.1310204 -0.79843104 -1.2384597 -0.5287469 -0.16102742 -0.7746671 -0.9888989 2.4106133 2.969474 -1.6896684 2.406242 2.4768593 -1.2553942 2.28092 2.1912448 -0.39044574 -0.055098232 -0.65303606 -0.8151839 2.7636564 2.3699954 -0.7103414 -1.2058061 -1.1242123 -1.644441 1.9539531 2.4701338 -0.7574959 -1.2997079 -1.5751598 -1.1974797 1.984369 2.5041182 -1.1190614 -1.2389251 -1.1250246 -1.7670592 2.259206 2.4144235 -1.2180661 -1.7944007 -1.3317927 -1.8562809 2.2697968 2.314291 -2.2212255 -0.688307 -1.323378 -1.7653801 2.2126975 2.662676 -1.2226671 -1.8406909 -1.3967581 -1.2797959 -2.6533988 -1.0032078 -1.5901774 1.9544287 2.440278 -1.3537337 -1.0186974 -1.055998 -0.793926 2.105353 2.7514546 -1.2841939 -0.3444586 -0.25658223 -0.36450016 2.4372416 2.7967212 -1.1107237 -1.4504517 -0.59935004 -1.7630986 -2.1962173 -1.9973363 -0.44816333 -2.8298714 -1.0860955 -0.16460083 2.065421 2.127853 -2.100988 -0.061961405 -1.2739246 -1.1534885 2.1659849 2.5505154 -1.9455972 1.7906635 2.011038 -1.2581095 -0.31615695 -0.11165155 -1.3336105 -1.135752 -1.1315887 -1.3508909 2.1069858 2.464483 -1.4480314 -2.070554 -1.4434295 -2.2109327 1.9800773 2.1201253 -0.82157356 -0.64087296 -1.2011358 -1.2303935 -0.76417947 -0.8821176 -1.7560211 1.806798 1.7799412 -1.46602 -0.5786136 -0.8467477 -0.81686956 -1.8378751 -1.2782296 -1.6491812 2.0951123 2.076922 -1.7928389 -1.876198 -1.6623555 -1.9162343 -1.5319293 -1.67211 -1.4404753 2.1809673 2.4743166 -1.7250624 2.0572731 1.9609805 -1.6244464 -1.5561239 -1.3048375 -1.2750388 2.1727788 2.227727 -1.8963141 -1.9799063 -1.6217684 -0.655886 -1.1716913 -1.5821164 -2.1715503 1.8616717 -0.25392514 -1.5866479 2.311988 2.575955 -1.7304353 -0.74557763 -0.023839474 -1.976039 -1.2629502 -1.5724685 -1.557685 1.745358 1.5977192 -0.6268201 -0.6753378 -0.9036633 -2.3970008 -2.1728013 0.8402529 -2.485703 2.1051674 2.5588818 -0.5293285 0.1047394 -0.83841515 -1.8388119 -1.121042 -0.5473406 0.18342915 0.45082858 1.2117448 -1.1729718 2.2594848 2.0489824 -1.3190506 2.1438456 2.0680904 -1.6166143 1.7864431 3.365782 -0.9410852 2.3720536 2.0786352 -0.80089426 0.4507 2.7977867 -0.7866118 -0.7323248 -0.002027524 -1.8839122 -2.0336807 -1.4288154 -1.6816655 2.2095976 2.5635092 -1.8744624 2.2336166 2.0021749 -0.8442069 2.1427312 2.4554627 -0.79128313 -0.40819448 -1.4359958 -1.1296735 1.7327051 2.124011 -2.0144992 -0.72713304 -1.5748868 0.017545681 2.3943992 2.9578488 -0.49101886 -2.345378 -1.1064922 -2.0144992 -0.72713304 -1.5748868 0.017545681 2.3943992 2.9578488 -0.49101886 -2.345378 -1.1064922 HPLA-glycine -1.1361474 4.266197 3.5624728 -1.4866307 -1.5035274 -1.1733428 -1.6437458 -1.5871589 -1.4332597 -1.3337675 2.9068987 -1.4574996 -1.6207385 3.512604 3.3170714 -1.3617569 -1.8217987 -0.8844643 -1.2421255 -1.191203 -0.52849686 -1.5621138 2.6497247 2.540304 -1.4208071 4.1683874 3.587941 -1.304574 -0.9628569 -0.6752361 -1.1068487 4.5781913 2.559565 -1.3337675 -0.89817476 -1.1503357 -1.5822233 -1.4208071 -1.086589 -1.5090674 -1.9822234 -1.0657059 -0.97508514 3.7409039 3.6090496 -0.7958192 3.7861567 3.3966272 -1.0762278 4.662786 2.8730302 -1.0762278 -1.4574996 -0.12490018 -1.3886378 4.351811 3.829407 -1.6392063 -1.4270619 -0.9247919 -1.2338994 -1.2042964 -1.1733428 -1.304574 3.9482055 3.6364625 -1.4081218 -1.8912101 -1.2894922 -1.2421255 3.450709 3.3585553 -1.4923098 3.8674057 3.192119 -1.3951948 3.1960886 3.2375712 -1.191203 3.306922 3.3877246 -1.4751279 -1.6346363 -1.3685776 -1.2894922 -1.4144942 -0.97508514 -1.1167561 -1.155 -0.6364458 -1.2818239 2.6169088 3.6373372 -1.5361087 2.8495245 2.7613745 -0.82667214 -1.021907 -0.9628569 -1.0441597 3.4227939 2.642663 -1.304574 -1.086589 -0.85618323 -1.2502531 2.6192296 2.4571683 -1.3820167 -1.0657059 -1.126521 -1.3820167 2.189046 3.1897862 -1.5569918 -1.4515204 -1.1823317 -1.6113127 3.20653 2.482568 -1.5822233 -1.5722431 -1.1456391 -1.5200136 2.5643737 3.5177634 -1.2662221 -1.3617569 -1.1068487 -1.3265861 2.6788619 -0.7958192 -1.2338994 -1.2421255 -0.6364458 -1.4979419 -1.5671973 -1.191203 -1.5413901 2.9443867 2.7279437 -1.191203 -1.297075 -0.9628569 -1.4693027 3.0007489 3.2909133 -1.1167561 -0.97508514 -0.6364458 -1.2740678 2.5819013 3.0366518 -1.592059 -1.3548672 -1.1642333 -1.4751279 -1.6254028 -1.4751279 -1.1733428 -1.3337675 -0.85618323 -1.4016889 2.4727592 2.297943 -1.3265861 -1.3337675 -1.4270619 -1.3193277 -1.3753304 3.4422178 -1.6254028 3.487112 -1.6113127 -1.3753304 -1.6254028 -0.97508514 -1.5200136 -1.530786 -1.4394015 -1.3951948 3.356759 3.5870066 -1.5254211 -1.6113127 -1.4923098 -1.5035274 2.1827352 2.485887 -1.6017542 -1.4574996 -1.6790081 -1.3193277 -1.3479066 -1.1642333 -1.6482551 -1.5090674 2.3261886 -1.2582846 -1.3886378 -1.3753304 -1.6790081 -1.5871589 -1.2421255 -1.6065502 3.158867 2.8506904 -1.5200136 -1.6482551 -1.592059 -1.7933695 -1.2740678 -1.4809037 -1.3479066 3.7499013 4.001948 -1.7043023 3.5550022 2.6440685 -1.551831 -1.4866307 -1.2818239 -1.5254211 2.7634876 2.487972 -1.7823938 -1.592059 -1.7897307 -1.3617569 -1.1823317 -1.3408738 -1.5772516 2.8372393 -1.7001516 -1.3479066 2.877005 3.8297002 -1.304574 -1.4394015 -1.2582846 -1.6659985 -1.616042 -1.7246836 -1.5254211 3.2051384 2.2261496 -1.0331246 -1.155 -1.2338994 -1.6790081 -1.6746992 -0.7467389 -1.4016889 3.8670924 3.719171 -1.2502531 -1.304574 -1.3408738 -1.311991 -1.3548672 -1.304574 -1.4515204 -1.2662221 -0.3711852 -1.4515204 3.594951 3.3495963 -1.6346363 3.2087584 3.2413795 -1.2818239 -1.5145626 4.7394924 -1.530786 3.5237362 3.656291 -1.1823317 -1.5822233 3.7173595 -1.5871589 -1.5822233 -1.311991 -1.4693027 -1.3685776 -0.8415881 -1.5035274 3.3010101 3.7181907 -1.4515204 2.8617458 -1.4332597 -1.3685776 3.5710967 3.467632 -1.4979419 -1.4809037 -1.4574996 -1.6392063 2.5354383 3.0453656 -0.89817476 -1.0331246 -1.3886378 -1.0331246 2.534215 4.1912484 -1.3886378 -1.3337675 -1.5671973 -0.89817476 -1.0331246 -1.3886378 -1.0331246 2.534215 4.1912484 -1.3886378 -1.3337675 -1.5671973 HPLA sulfate -0.31655407 2.6785839 2.7976468 -0.44714978 -0.52789724 0.012428501 -0.9951886 -0.52109617 -0.41255808 -0.21906795 1.7402418 -0.17108412 -1.6179156 2.6331055 2.5229893 -0.61232907 -1.1861345 0.36288747 -0.64752835 -0.41226426 0.020373218 -0.8881431 0.7065636 2.0454102 -1.2462577 3.0391223 2.5676546 -0.35007718 0.72629225 0.76049745 -0.9899945 2.6861792 2.5409045 -1.125403 -0.3074375 -0.18266922 -1.6217942 -0.49063694 -0.21587563 -0.94192624 -1.4368775 -0.19044034 -0.45306113 1.9044257 3.369522 -0.6121249 1.6661922 2.7126842 0.2807694 4.1431246 2.3108666 -0.18195605 -0.68849826 1.040295 -0.18353139 3.8598902 2.0569887 -0.63922703 -0.37819627 0.49301812 -0.38048303 -0.4160935 -0.13416517 -0.21961515 2.489669 2.5281482 -1.2039465 -0.86966544 -0.044221442 -0.5595289 1.7750423 1.7467349 -0.851067 2.1446187 1.8825722 0.26258558 1.6082684 1.6797309 -0.26166242 2.352353 3.3328295 -1.2318151 -0.65295464 -1.3865154 -0.24066342 -0.13387251 -0.36151156 -0.6629873 0.9582837 1.4296935 -1.4560812 0.9759831 2.5218492 -1.3899475 1.8465635 1.3254333 -0.33536953 -0.17393039 -0.19018756 -0.23213632 2.8379767 2.3442125 -1.4328225 -1.1714315 -0.8087663 -0.93253523 1.5465757 1.7414387 -1.420879 -0.46702918 -0.36870438 -1.1039642 0.27943864 2.8058777 -0.80715466 -0.63750684 -0.58195776 -0.75437737 2.306489 1.5715364 -0.71068084 -1.2294339 -0.7883462 -1.982921 2.2222173 2.5198984 -0.5590685 -0.69385886 -0.45765164 -1.1208553 1.6672226 1.7066758 -1.4572366 -1.213192 -0.2716781 -0.06842039 -1.668988 -0.4240963 -0.3661355 2.4278803 2.620632 -0.0579332 -0.7738872 -0.3198197 -0.8168131 2.2415001 2.4017575 -1.0515517 -0.7896183 -0.60636437 -0.37603444 2.843267 3.3041062 -1.0861452 -1.6889764 -0.450043 -1.6936187 -1.9296821 -1.4733765 -0.6822638 -1.3490199 -0.8865244 -0.4109323 1.5433183 2.281605 -1.2170342 -1.0909492 -1.4340072 -1.8398685 0.47657856 2.2057695 -2.0211444 1.7151073 1.2894123 -1.5491997 -1.3501542 -1.0412117 -1.8328998 -1.234042 -0.62630415 -1.4839991 1.0007133 2.9915292 -0.63081723 -1.1966012 -0.535127 -1.2974297 1.2188781 2.4776752 -0.8759926 -1.2275548 -1.1568741 -1.0626618 -0.8321694 -0.5529413 -1.5608598 0.2440534 2.2567291 -0.3873304 -0.22851996 -1.0000794 -1.1606569 -1.7944319 -1.0023134 -1.2926891 2.1473143 1.3121808 -1.742901 -1.2828593 -1.1276987 -1.8154767 -1.4094733 -0.9228263 -1.096257 1.9253995 1.0747402 -1.7200521 2.0381668 1.5144536 -1.6573354 -1.3887963 -0.6408276 -1.2436748 1.261309 1.7521418 -1.7357175 -1.623478 -1.3942618 -1.6402748 -1.6512041 -1.4881527 -1.4909714 1.0372746 -0.114691645 -1.7438716 1.3819512 3.0264447 -1.7221037 -1.3713233 -0.7177288 -2.1093972 -2.0366864 -2.2594821 -0.7435453 1.372355 0.89755815 -0.7152743 -1.0638735 -1.0858936 -2.1172462 -1.0834948 -0.38368884 -1.7456058 1.8065097 1.5616546 -0.9152546 -0.47450647 -0.4613818 -1.598743 -1.0747255 -0.56299096 -0.41388357 -0.00205392 -0.3095325 -1.1083031 1.4250513 1.6911612 -1.5905291 2.3929448 1.7911434 -0.49047858 1.7178674 3.9706752 -0.9041387 2.592913 2.8307874 -1.1529217 0.018482344 1.5565655 -1.0908612 -1.2585261 -0.07508771 -1.8277262 -1.7676682 -0.8876024 -1.6380197 1.933804 3.041757 -0.869981 2.3850517 1.2101445 -1.3703579 1.7598273 2.150262 -1.3524281 -0.6590255 -1.4048617 -0.8728871 0.32047772 1.9810454 -0.81365424 -1.1100262 -0.8664655 -0.54350805 1.8136233 2.9800467 -1.0783143 -1.4363567 -0.38527885 -0.81365424 -1.1100262 -0.8664655 -0.54350805 1.8136233 2.9800467 -1.0783143 -1.4363567 -0.38527885 HGA 1.3078661 -0.94549596 -1.8597862 1.0242822 0.87691426 1.5677495 1.1371841 0.8338247 1.3010653 1.6500258 0.003083633 1.2124139 1.2008011 -1.8220799 -1.4805485 1.0243826 0.51312584 1.3938564 1.0562999 1.0285914 2.146043 0.91962236 -2.895246 -2.8944094 1.3167866 -2.032027 -1.972922 1.0391693 1.502421 1.8482808 1.2919269 -3.0282974 -3.0025854 1.4539853 1.8079898 1.4577245 1.0527567 1.2845771 1.7310897 0.8190268 0.49072832 1.4813846 1.7409489 -2.893869 -2.4904208 1.7705666 -3.8975122 -3.1244066 1.7230835 -1.9042158 -2.9520173 1.2130684 0.8485683 2.2847836 1.2661858 -0.27486396 -2.1867948 1.0694677 1.3543745 1.8509449 1.3306038 1.228864 1.4579713 1.3628947 -2.6639028 -2.1724718 1.179814 0.5802802 1.1683025 1.2058171 -3.2634106 -2.8779097 0.8726592 -1.8408227 -2.509117 1.3704762 -3.5791743 -3.1905732 1.0728585 -5.0793805 -3.8873253 1.1542916 0.9737706 1.2880121 1.4503877 1.2271154 1.5380856 1.263607 -3.6405473 -2.3378963 0.98952204 -3.2133136 -2.7626343 1.3400716 -1.7747042 -2.2506166 1.7481049 1.5734268 1.5737522 1.5650523 -1.6653466 -2.0700927 1.0811667 1.3124312 1.6115568 1.2397822 -2.9643466 -2.2107072 1.1586883 1.4469758 1.2770187 1.4373997 -0.83593667 -0.25896698 1.06212 1.0936027 1.3508773 0.98145264 -3.0535855 -2.5349653 0.9867717 0.99652445 1.3933104 1.0162559 -2.0490563 -1.8423635 0.9539097 0.8580631 1.3583896 1.1106199 -2.153122 -2.5163054 1.1787951 1.2310162 1.6081058 1.2583714 0.8897326 1.5344348 1.160986 -1.6757579 -1.8495315 1.4123924 1.2487309 1.6119683 1.252717 -0.3794786 -2.0247254 1.6235008 1.6207173 1.918814 1.5965421 -2.1458433 -1.8168914 0.7673278 0.9672069 1.4607769 1.2563406 0.992165 1.0761027 1.5411481 0.9829804 1.3605458 1.102415 -3.7655244 -3.612811 0.96711856 1.0186579 0.84596246 0.9497861 -3.712142 -2.2318559 0.68481755 -2.5215642 -2.5436034 1.0924172 0.8485442 1.6655163 0.9329406 0.96842444 1.1086615 1.0477487 -2.1913269 -2.1148193 0.9083689 0.64952236 0.6969694 0.7848007 -2.5424547 -2.0513098 0.9180193 1.1626071 0.91862863 1.1265972 1.0867448 1.3853735 0.6629581 -2.130619 -1.8142253 1.0976791 0.9323745 0.93115985 1.0373485 1.0282813 1.2445401 1.0052605 -2.1329708 0.013461785 0.80559015 0.7818677 0.9455492 0.47883645 1.2529157 0.9055292 1.1961155 -2.687765 -2.491146 0.9757762 -2.0690205 -2.1427808 0.9452731 0.9607595 1.3243673 0.96232045 -2.1545944 -2.202722 0.77380425 0.89730716 0.6808676 0.98037755 1.1604398 1.1271071 0.8352501 -1.7495614 0.18371408 1.3418281 -2.8071709 -2.109734 1.096328 1.1721189 1.5440792 0.9008967 0.83530325 0.6094642 0.83468795 -2.6761584 -2.2777941 1.3854738 1.3965807 1.1894593 0.8324645 0.710911 1.907952 1.0190344 -2.9653766 -1.0294226 1.2844577 1.3205098 1.0691314 1.0568551 1.0116345 1.3143646 1.0900272 1.3563138 2.278503 0.8236503 -3.0041704 -0.58261395 0.8986031 -3.1166027 -2.0157135 1.1163244 -3.7494547 -0.88756543 1.0513172 -1.6897367 -1.388153 1.0779316 -0.15703744 0.8092289 0.86522514 0.93406785 1.4362996 1.0720153 1.1539423 1.8531291 0.9213569 -2.1902368 -0.4563185 1.2340345 -3.205362 -3.3338368 0.9917655 -2.9738462 -2.3771615 0.93431175 0.9426472 0.9918328 0.7086645 -3.401143 -1.9805508 1.6597636 1.3524492 1.1386999 1.4560772 -3.0812473 -2.5769157 1.1752136 0.95222336 0.878707 1.6597636 1.3524492 1.1386999 1.4560772 -3.0812473 -2.5769157 1.1752136 0.95222336 0.878707 Acetyl-HGA 1.8618062 0.028706884 0.32109535 1.5863447 1.5852056 2.3059433 1.2655277 1.4782757 1.1438272 2.0572956 -0.76365864 1.6833174 1.1170474 -0.99803025 -1.4652134 1.3966078 0.5729653 2.0257814 1.2528108 1.0462946 2.81215 1.4959145 -1.6973094 -0.8734992 1.3900688 -0.17659932 -0.18284808 1.3248044 1.9179714 2.2568817 1.5354242 -0.4006995 -0.64087784 2.048134 1.657718 1.9207885 0.70953923 1.4338491 2.1971836 0.025663028 -0.44882 1.8363134 1.6342108 -2.7623277 -0.15377338 1.395658 -1.8895732 -0.28029388 1.7280654 1.1960751 -0.3519733 1.3240628 0.07354494 2.4395483 2.2368221 0.29674384 0.7737167 1.6883309 1.2549839 2.8108418 1.6022738 1.28125 1.4626063 1.8895156 -0.6534191 0.012197294 1.231553 0.52494824 1.7840847 2.0291977 -1.1118584 -0.1489508 1.2076886 -0.08988289 -0.05379865 1.3584604 -1.1225513 0.51371187 0.8488773 -1.4896472 1.3650373 0.63429576 0.12969956 0.6554821 -0.8698742 2.0845668 1.4648695 -0.14226532 -1.9932446 -0.7388823 0.15712938 -1.7529749 0.08461496 1.6401229 -0.99543905 -0.92132217 1.8840495 1.8080393 1.5920912 1.1538182 0.17101859 -1.0379834 0.11493092 1.4005761 1.6061374 0.82361925 -1.6153512 -1.4205511 1.0193902 1.6294532 1.4734676 1.383533 -1.3237016 -0.05702873 1.7220889 0.87629193 1.2826742 0.80090463 -0.9149137 -1.4583219 1.280578 0.32622078 0.5633175 0.45801717 -2.1259537 -1.5081912 0.9763058 0.360183 0.8750924 0.88568527 -0.96456707 -0.6505111 0.9618976 1.2135543 0.9216012 1.760321 -0.13694437 1.634621 1.6412641 -1.3050786 -1.0176858 1.3597236 1.1238755 1.4872296 1.013331 -0.20832951 -0.8869272 1.4922749 1.550967 1.999333 2.051683 -0.78527576 -0.5518114 0.793066 0.25227425 1.4669789 1.2676988 0.53028375 0.54786694 1.5607268 0.99108964 0.22186218 1.2298696 -1.5874349 -1.6296738 -0.50838757 -1.1299943 0.084322035 -5.573584 -1.9275217 -0.7819814 -0.8189471 -3.8981206 -2.8350308 -0.7279899 -0.40833995 0.45325622 -0.9728623 -1.814027 0.41334215 0.42488402 -2.6970649 -1.5675455 1.2835603 -0.92428386 0.21900389 0.14012276 -1.8123264 -1.3468351 1.1240524 -0.7447984 0.2325306 -0.24362844 -0.94473195 0.13665476 -0.057804108 -3.8884463 -2.2845628 -0.450722 -0.8567895 0.5479809 0.28827298 0.023415094 0.91632795 0.41734362 -1.7195289 -0.12635946 -0.42683372 0.6870838 1.0606325 -2.2315335 -1.1309831 -0.003129347 0.18001032 -1.6656282 -1.2172104 -0.39854503 -1.692779 -1.9131103 -0.6501983 0.22873323 0.17442296 -0.21395864 -2.1232624 -2.096961 -0.46272245 0.123010755 -0.54588675 -0.010950062 0.20180574 -0.5047718 0.66646135 -1.170801 -1.0016918 -0.06786414 -2.387352 -2.0766356 -3.7772572 -0.022893535 0.16044031 0.63124394 0.5329154 -1.7811741 0.99742323 -1.5096486 -2.0007446 -0.036505066 -0.06408268 -0.82272786 -0.4803136 1.128987 0.646892 -0.7748009 -2.0768907 -2.5523174 0.6541958 0.72388506 0.84450936 -0.23546113 1.191102 0.5556452 0.6578434 1.0145538 -1.4236048 0.22893271 -2.4689 -1.3070025 0.17332749 -1.1187181 -1.4789456 0.33166897 -1.3625919 -0.22166868 1.0056986 -1.1460824 -0.4293295 -0.81805706 -1.1690296 -0.2532259 0.04795747 0.09973881 0.53702885 -0.026882425 -0.10232407 0.14646098 -0.2548966 -1.5007529 -1.1106907 1.0415045 -1.4474128 -1.7808175 0.2056263 -1.2893047 -1.0208861 -0.45134428 -0.21014933 -0.8282715 -0.08930103 -2.1649995 -1.0777166 -0.32488278 -0.39639184 1.1944727 1.3572814 -0.9081838 -0.034933105 0.7014123 -0.5833064 0.32349902 -0.32488278 -0.39639184 1.1944727 1.3572814 -0.9081838 -0.034933105 0.7014123 -0.5833064 0.32349902 HGA sulfate 1.7476889 -1.7791508 -2.6073241 1.3524642 1.43888 2.0075912 1.8062285 1.6743753 1.5800322 2.1538625 -1.151598 1.7059642 1.8567506 -1.621446 -3.2683258 1.8804629 1.6558018 2.2527163 1.5794864 1.5613222 2.5272307 1.6120025 -3.6745296 -2.1569312 1.6252583 -1.9021457 -1.9711256 1.7748854 1.4791507 2.4231272 1.6997944 -2.2090693 -3.2701707 1.5446454 2.3751523 2.030324 1.1471816 1.4946103 2.0141678 0.26093256 0.5028394 1.9593147 2.3962088 -3.3732955 -2.678259 1.7216643 -6.012784 -3.2454557 2.4031649 -1.6294383 -3.552876 1.7299087 1.4088912 2.735123 2.1010234 -0.44938013 -1.8613969 1.602981 1.666523 2.3975904 2.0296435 1.568224 1.828833 1.8058364 -2.6170695 -2.5605795 1.0127838 1.1536902 1.8734185 1.873948 -2.9211912 -2.43705 1.4788733 -2.738502 -2.5898242 1.948307 -3.0523956 -2.47776 1.8237132 -6.3349886 -5.1247606 1.4865476 1.156692 1.6189909 1.9689841 1.6401595 1.6833751 0.9233111 -4.739272 -3.6628025 0.3816115 -4.6804085 -2.4341464 1.3167069 -2.8721218 -3.4466014 1.9744337 1.9093717 1.8847189 0.9095506 -2.736851 -2.797231 1.1010118 1.202529 1.021152 1.5665722 -3.0690963 -2.8355112 0.47104803 1.5382931 1.6975563 1.8310938 -1.8577206 -0.5763332 1.6275868 1.3976487 1.4596664 1.8706905 -2.3380942 -3.115685 1.6566638 1.0846791 1.1216418 0.696156 -2.4132843 -2.0067947 1.3443282 0.5336544 0.7078658 0.5386712 -2.7068563 -4.2930856 0.41032112 0.3319632 0.108588316 1.8611773 0.54044855 2.1343565 1.7760583 -3.0047314 -2.531469 1.9882072 1.620068 2.0467055 2.0011296 -0.35419267 -3.1294324 1.5333974 1.7907896 1.9089552 2.1740878 -2.252466 -1.7712823 1.3345412 0.8409841 1.8193642 1.3457739 0.812574 1.3324593 1.6867591 1.4350839 0.6334931 1.8518486 -3.6563427 -3.1516645 -0.12033512 0.2289781 0.17273578 -0.2108022 -4.9879045 -3.0234795 0.62425566 -2.907037 -3.5272462 0.7862201 1.1655202 1.3050722 0.7085444 1.4171926 1.1942402 1.5264152 -2.677465 -2.0194306 1.9669808 1.4060495 1.4334276 1.4808259 -3.284794 -2.0188253 1.4975046 1.6369708 1.2855679 0.6954381 0.7493003 2.0525012 1.0689371 -2.9660728 -2.0599923 0.7819293 0.77327645 1.635946 1.2620472 1.3404652 1.190014 1.2997165 -2.4860036 -0.41896316 1.069557 1.204112 1.4075468 1.272923 1.0560164 1.7137315 1.14221 -3.1495981 -3.4513752 1.0264796 -2.1703472 -2.5014226 0.9138025 1.283093 1.3316199 0.64764893 -2.9030592 -2.9098535 0.48858464 1.0699179 0.8880097 1.0721918 1.3804722 0.62847006 0.4301886 -6.421389 -0.5552269 1.248738 -3.8219273 -2.6585448 1.2547218 1.0327299 2.081843 1.0890859 0.010009629 -0.37164614 1.5027627 -2.781563 -3.1306794 0.96401966 0.9834782 0.9444698 0.84967625 1.525875 1.9659598 0.6612454 -3.8752117 -1.8386253 1.2805295 1.3856398 1.7532216 0.37237084 1.4235269 1.8576171 1.5203377 1.5422726 1.8177006 1.4352456 -3.206965 -0.61807865 1.1810079 -2.57278 -2.318567 1.3945448 -2.599414 -0.5367668 1.7069229 -2.0797772 -1.8525336 0.75803226 -0.71839494 -0.11306475 1.3925759 1.3471256 2.2797365 0.7080465 0.8906243 1.6968026 0.72693485 -2.621368 -0.3143769 1.9743849 -2.5305014 -3.2245083 0.9317733 -4.1170073 -2.7023196 0.2884002 0.24893998 0.59481096 1.3657994 -3.8032327 -1.9949495 2.0503533 1.2742974 1.6544428 1.7920158 -3.8215492 -2.378256 1.1402501 0.97675496 0.48791417 2.0503533 1.2742974 1.6544428 1.7920158 -3.8215492 -2.378256 1.1402501 0.97675496 0.48791417 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name retention time neutral mass formula CAS-ID KEGG-ID Phenylalanine N-acetylcysteine 4.729989 326.0966 C14 H18 N2 O5 S O-Methyl-phenylalanine 4.9100037 179.0942 C10 H13 N O2 Phenyllactic acid 6.7199783 166.063 C9 H10 O3 6482-98-0 Tyrosine 2.17 181.0739 C9 H11 N O3 60-18-4 C00082 N-Acetyl-tyrosine 4.890012 223.0845 C11 H13 N O4 537-55-3 Tyrosine-sulfate 1.9800003 261.0306 C9 H11 N O6 S HPPA 3.680001 180.0425 C9 H8 O4 C01179 HPPA-sulfate 5.2900095 259.9991 C9 H8 O7 S HPLA 4.7399926 182.058 C9 H10 O4 6482-98-0 HPLA-glycine 4.6700096 239.0774 C11 H13 N O5 HPLA sulfate 3.8299978 262.0146 C9 H10 O7 S HGA 3.5200083 168.0425 C8 H8 O4 451-13-8 C00544 Acetyl-HGA 6.3800044 210.0525 C10 H10 O5 HGA sulfate 2.7600062 247.9991 C8 H8 O7 S METABOLITES_END #END