#METABOLOMICS WORKBENCH arthurzhu233_20230210_050308 DATATRACK_ID:3732 STUDY_ID:ST002475 ANALYSIS_ID:AN004043 PROJECT_ID:PR001598 VERSION 1 CREATED_ON February 13, 2023, 8:02 am #PROJECT PR:PROJECT_TITLE Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and PR:PROJECT_TITLE insomnia symptoms in test anxious college students via modulating the gut PR:PROJECT_TITLE microbiota and its metabolism PR:PROJECT_SUMMARY Test anxiety frequently occurs in college students and harms their physical and PR:PROJECT_SUMMARY psychological health, but suitable interventions or therapeutical strategies are PR:PROJECT_SUMMARY still missing. The present study aims to evaluate the potential effects of PR:PROJECT_SUMMARY Lactobacillus plantarum JYLP-326 on test anxious college students. Sixty anxious PR:PROJECT_SUMMARY students were enrolled and randomly allocated to the placebo group and the PR:PROJECT_SUMMARY probiotic group, which were instructed to take placebo and JYLP-326 products PR:PROJECT_SUMMARY twice per day for three weeks, respectively. Thirty unanxious students with no PR:PROJECT_SUMMARY treatments were assigned to a regular control group. The anxiety, depression, PR:PROJECT_SUMMARY and insomnia questionnaires were used to measure students’ mental states at PR:PROJECT_SUMMARY the baseline and the end of this study. 16S rRNA sequencing and untargeted PR:PROJECT_SUMMARY metabolomics were performed to analyze the changes in the gut microbiota and PR:PROJECT_SUMMARY fecal metabolism. The questionnaire results suggested that JYLP-326 PR:PROJECT_SUMMARY administration could relieve the symptoms of anxiety, depression, and insomnia PR:PROJECT_SUMMARY in test anxious students. The gut microbiomes of the placebo group showed a PR:PROJECT_SUMMARY significantly greater α diversity index than the control group (p < 0.05). An PR:PROJECT_SUMMARY increased abundance of Bacteroides and Roseburia was observed in the placebo PR:PROJECT_SUMMARY group, and the relative abundance of Prevotella and Bifidobacterium decreased. PR:PROJECT_SUMMARY Whereas JYLP-326 administration could partly restore the disturbed gut PR:PROJECT_SUMMARY microbiota. Additionally, test anxiety was correlation with disordered fecal PR:PROJECT_SUMMARY metabolomics such as a higher Ethyl sulfate and a lower Cyclohexylamine, which PR:PROJECT_SUMMARY could be reversed after taking JYLP-326. Furthermore, the changed microbiota and PR:PROJECT_SUMMARY fecal metabolites were significantly associated with anxiety-related symptoms. PR:PROJECT_SUMMARY These results indicated that the intervention of L. plantarum JYLP-326 could be PR:PROJECT_SUMMARY an effective strategy to alleviate anxiety, depression and insomnia in test PR:PROJECT_SUMMARY anxious college students. PR:INSTITUTE Nanchang university PR:LAST_NAME Ruizhe PR:FIRST_NAME Zhu PR:ADDRESS National Engineering Research Center for Bioengineering Drugs and the PR:ADDRESS Technologies, Institute of Translational Medicine, Nanchang University, PR:ADDRESS Nanchang, China PR:EMAIL arthurzhu233@outlook.com PR:PHONE 18779116254 #STUDY ST:STUDY_TITLE Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and ST:STUDY_TITLE insomnia symptoms in test anxious college students via modulating the gut ST:STUDY_TITLE microbiota and its metabolism ST:STUDY_SUMMARY Test anxiety frequently occurs in college students and harms their physical and ST:STUDY_SUMMARY psychological health, but suitable interventions or therapeutical strategies are ST:STUDY_SUMMARY still missing. The present study aims to evaluate the potential effects of ST:STUDY_SUMMARY Lactobacillus plantarum JYLP-326 on test anxious college students. Sixty anxious ST:STUDY_SUMMARY students were enrolled and randomly allocated to the placebo group and the ST:STUDY_SUMMARY probiotic group, which were instructed to take placebo and JYLP-326 products ST:STUDY_SUMMARY twice per day for three weeks, respectively. Thirty unanxious students with no ST:STUDY_SUMMARY treatments were assigned to a regular control group. The anxiety, depression, ST:STUDY_SUMMARY and insomnia questionnaires were used to measure students’ mental states at ST:STUDY_SUMMARY the baseline and the end of this study. 16S rRNA sequencing and untargeted ST:STUDY_SUMMARY metabolomics were performed to analyze the changes in the gut microbiota and ST:STUDY_SUMMARY fecal metabolism. The questionnaire results suggested that JYLP-326 ST:STUDY_SUMMARY administration could relieve the symptoms of anxiety, depression, and insomnia ST:STUDY_SUMMARY in test anxious students. The gut microbiomes of the placebo group showed a ST:STUDY_SUMMARY significantly greater α diversity index than the control group (p < 0.05). An ST:STUDY_SUMMARY increased abundance of Bacteroides and Roseburia was observed in the placebo ST:STUDY_SUMMARY group, and the relative abundance of Prevotella and Bifidobacterium decreased. ST:STUDY_SUMMARY Whereas JYLP-326 administration could partly restore the disturbed gut ST:STUDY_SUMMARY microbiota. Additionally, test anxiety was correlation with disordered fecal ST:STUDY_SUMMARY metabolomics such as a higher Ethyl sulfate and a lower Cyclohexylamine, which ST:STUDY_SUMMARY could be reversed after taking JYLP-326. Furthermore, the changed microbiota and ST:STUDY_SUMMARY fecal metabolites were significantly associated with anxiety-related symptoms. ST:STUDY_SUMMARY These results indicated that the intervention of L. plantarum JYLP-326 could be ST:STUDY_SUMMARY an effective strategy to alleviate anxiety, depression and insomnia in test ST:STUDY_SUMMARY anxious college students. ST:INSTITUTE Nanchang university ST:LAST_NAME Ruizhe ST:FIRST_NAME Zhu ST:ADDRESS National Engineering Research Center for Bioengineering Drugs and the ST:ADDRESS Technologies, Institute of Translational Medicine, Nanchang University, ST:ADDRESS Nanchang, China ST:EMAIL arthurzhu233@outlook.com ST:PHONE 18779116254 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - NHP1 treatment:Control RAW_FILE_NAME=HP1_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP2 treatment:Control RAW_FILE_NAME=HP2_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP3 treatment:Control RAW_FILE_NAME=HP3_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP4 treatment:Control RAW_FILE_NAME=HP4_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP5 treatment:Control RAW_FILE_NAME=HP5_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP6 treatment:Control RAW_FILE_NAME=HP6_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP7 treatment:Control RAW_FILE_NAME=HP7_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP8 treatment:Control RAW_FILE_NAME=HP8_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP9 treatment:Control RAW_FILE_NAME=HP9_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP10 treatment:Control RAW_FILE_NAME=HP10_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP11 treatment:Control RAW_FILE_NAME=HP11_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP12 treatment:Control RAW_FILE_NAME=HP12_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP13 treatment:Control RAW_FILE_NAME=HP13_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP14 treatment:Control RAW_FILE_NAME=HP14_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP15 treatment:Control RAW_FILE_NAME=HP15_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP16 treatment:Control RAW_FILE_NAME=HP16_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP17 treatment:Control RAW_FILE_NAME=HP17_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP18 treatment:Control RAW_FILE_NAME=HP18_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP19 treatment:Control RAW_FILE_NAME=HP19_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP20 treatment:Control RAW_FILE_NAME=HP20_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP21 treatment:Control RAW_FILE_NAME=HP21_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP22 treatment:Control RAW_FILE_NAME=HP22_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP23 treatment:Control RAW_FILE_NAME=HP23_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP24 treatment:Control RAW_FILE_NAME=HP24_NEG.wiff SUBJECT_SAMPLE_FACTORS - NHP25 treatment:Control RAW_FILE_NAME=HP25_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP1 treatment:Placebo RAW_FILE_NAME=P1_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP2 treatment:Placebo RAW_FILE_NAME=P2_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP3 treatment:Placebo RAW_FILE_NAME=P3_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP4 treatment:Placebo RAW_FILE_NAME=P4_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP5 treatment:Placebo RAW_FILE_NAME=P5_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP6 treatment:Placebo RAW_FILE_NAME=P6_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP7 treatment:Placebo RAW_FILE_NAME=P7_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP8 treatment:Placebo RAW_FILE_NAME=P8_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP9 treatment:Placebo RAW_FILE_NAME=P9_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP10 treatment:Placebo RAW_FILE_NAME=P10_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP11 treatment:Placebo RAW_FILE_NAME=P11_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP12 treatment:Placebo RAW_FILE_NAME=P12_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP13 treatment:Placebo RAW_FILE_NAME=P13_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP14 treatment:Placebo RAW_FILE_NAME=P14_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP15 treatment:Placebo RAW_FILE_NAME=P15_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP16 treatment:Placebo RAW_FILE_NAME=P16_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP17 treatment:Placebo RAW_FILE_NAME=P17_NEG.wiff SUBJECT_SAMPLE_FACTORS - NP18 treatment:Placebo RAW_FILE_NAME=P18_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB1 treatment:Treatment RAW_FILE_NAME=PB1_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB2 treatment:Treatment RAW_FILE_NAME=PB2_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB3 treatment:Treatment RAW_FILE_NAME=PB3_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB4 treatment:Treatment RAW_FILE_NAME=PB4_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB5 treatment:Treatment RAW_FILE_NAME=PB5_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB6 treatment:Treatment RAW_FILE_NAME=PB6_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB7 treatment:Treatment RAW_FILE_NAME=PB7_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB8 treatment:Treatment RAW_FILE_NAME=PB8_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB9 treatment:Treatment RAW_FILE_NAME=PB9_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB10 treatment:Treatment RAW_FILE_NAME=PB10_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB11 treatment:Treatment RAW_FILE_NAME=PB11_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB12 treatment:Treatment RAW_FILE_NAME=PB12_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB13 treatment:Treatment RAW_FILE_NAME=PB13_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB14 treatment:Treatment RAW_FILE_NAME=PB14_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB15 treatment:Treatment RAW_FILE_NAME=PB15_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB16 treatment:Treatment RAW_FILE_NAME=PB16_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB17 treatment:Treatment RAW_FILE_NAME=PB17_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB18 treatment:Treatment RAW_FILE_NAME=PB18_NEG.wiff SUBJECT_SAMPLE_FACTORS - NPB19 treatment:Treatment RAW_FILE_NAME=PB19_NEG.wiff SUBJECT_SAMPLE_FACTORS - PHP1 treatment:Control RAW_FILE_NAME=HP1_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP2 treatment:Control RAW_FILE_NAME=HP2_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP3 treatment:Control RAW_FILE_NAME=HP3_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP4 treatment:Control RAW_FILE_NAME=HP4_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP5 treatment:Control RAW_FILE_NAME=HP5_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP6 treatment:Control RAW_FILE_NAME=HP6_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP7 treatment:Control RAW_FILE_NAME=HP7_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP8 treatment:Control RAW_FILE_NAME=HP8_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP9 treatment:Control RAW_FILE_NAME=HP9_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP10 treatment:Control RAW_FILE_NAME=HP10_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP11 treatment:Control RAW_FILE_NAME=HP11_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP12 treatment:Control RAW_FILE_NAME=HP12_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP13 treatment:Control RAW_FILE_NAME=HP13_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP14 treatment:Control RAW_FILE_NAME=HP14_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP15 treatment:Control RAW_FILE_NAME=HP15_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP16 treatment:Control RAW_FILE_NAME=HP16_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP17 treatment:Control RAW_FILE_NAME=HP17_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP18 treatment:Control RAW_FILE_NAME=HP18_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP19 treatment:Control RAW_FILE_NAME=HP19_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP20 treatment:Control RAW_FILE_NAME=HP20_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP21 treatment:Control RAW_FILE_NAME=HP21_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP22 treatment:Control RAW_FILE_NAME=HP22_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP23 treatment:Control RAW_FILE_NAME=HP23_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP24 treatment:Control RAW_FILE_NAME=HP24_POS.wiff SUBJECT_SAMPLE_FACTORS - PHP25 treatment:Control RAW_FILE_NAME=HP25_POS.wiff SUBJECT_SAMPLE_FACTORS - PP1 treatment:Placebo RAW_FILE_NAME=P1_POS.wiff SUBJECT_SAMPLE_FACTORS - PP2 treatment:Placebo RAW_FILE_NAME=P2_POS.wiff SUBJECT_SAMPLE_FACTORS - PP3 treatment:Placebo RAW_FILE_NAME=P3_POS.wiff SUBJECT_SAMPLE_FACTORS - PP4 treatment:Placebo RAW_FILE_NAME=P4_POS.wiff SUBJECT_SAMPLE_FACTORS - PP5 treatment:Placebo RAW_FILE_NAME=P5_POS.wiff SUBJECT_SAMPLE_FACTORS - PP6 treatment:Placebo RAW_FILE_NAME=P6_POS.wiff SUBJECT_SAMPLE_FACTORS - PP7 treatment:Placebo RAW_FILE_NAME=P7_POS.wiff SUBJECT_SAMPLE_FACTORS - PP8 treatment:Placebo RAW_FILE_NAME=P8_POS.wiff SUBJECT_SAMPLE_FACTORS - PP9 treatment:Placebo RAW_FILE_NAME=P9_POS.wiff SUBJECT_SAMPLE_FACTORS - PP10 treatment:Placebo RAW_FILE_NAME=P10_POS.wiff SUBJECT_SAMPLE_FACTORS - PP11 treatment:Placebo RAW_FILE_NAME=P11_POS.wiff SUBJECT_SAMPLE_FACTORS - PP12 treatment:Placebo RAW_FILE_NAME=P12_POS.wiff SUBJECT_SAMPLE_FACTORS - PP13 treatment:Placebo RAW_FILE_NAME=P13_POS.wiff SUBJECT_SAMPLE_FACTORS - PP14 treatment:Placebo RAW_FILE_NAME=P14_POS.wiff SUBJECT_SAMPLE_FACTORS - PP15 treatment:Placebo RAW_FILE_NAME=P15_POS.wiff SUBJECT_SAMPLE_FACTORS - PP16 treatment:Placebo RAW_FILE_NAME=P16_POS.wiff SUBJECT_SAMPLE_FACTORS - PP17 treatment:Placebo RAW_FILE_NAME=P17_POS.wiff SUBJECT_SAMPLE_FACTORS - PP18 treatment:Placebo RAW_FILE_NAME=P18_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB1 treatment:Treatment RAW_FILE_NAME=PB1_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB2 treatment:Treatment RAW_FILE_NAME=PB2_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB3 treatment:Treatment RAW_FILE_NAME=PB3_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB4 treatment:Treatment RAW_FILE_NAME=PB4_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB5 treatment:Treatment RAW_FILE_NAME=PB5_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB6 treatment:Treatment RAW_FILE_NAME=PB6_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB7 treatment:Treatment RAW_FILE_NAME=PB7_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB8 treatment:Treatment RAW_FILE_NAME=PB8_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB9 treatment:Treatment RAW_FILE_NAME=PB9_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB10 treatment:Treatment RAW_FILE_NAME=PB10_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB11 treatment:Treatment RAW_FILE_NAME=PB11_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB12 treatment:Treatment RAW_FILE_NAME=PB12_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB13 treatment:Treatment RAW_FILE_NAME=PB13_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB14 treatment:Treatment RAW_FILE_NAME=PB14_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB15 treatment:Treatment RAW_FILE_NAME=PB15_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB16 treatment:Treatment RAW_FILE_NAME=PB16_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB17 treatment:Treatment RAW_FILE_NAME=PB17_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB18 treatment:Treatment RAW_FILE_NAME=PB18_POS.wiff SUBJECT_SAMPLE_FACTORS - PPB19 treatment:Treatment RAW_FILE_NAME=PB19_POS.wiff #COLLECTION CO:COLLECTION_SUMMARY The first pooped fecal sample in a day were collected during 3 days after the CO:COLLECTION_SUMMARY indicated time points and stored at -80 oC immediately for further research CO:SAMPLE_TYPE Feces #TREATMENT TR:TREATMENT_SUMMARY Out of those 60 students with anxiety and depression facing UNGEE, 30 were TR:TREATMENT_SUMMARY selected randomly as the PB group to receive the probiotic product; another 30 TR:TREATMENT_SUMMARY received placebo product were regarded as the P group. The 30 un-anxious TR:TREATMENT_SUMMARY students were assigned as the healthy control group (HP group). #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Stool weighing 100 mg was added with 400 ml extract of SP:SAMPLEPREP_SUMMARY methanol-acetonitrile-water (2:2:1, vol/vol/vol), vortexed and centrifuged at SP:SAMPLEPREP_SUMMARY 14,000 g for 20min, and the supernatant was collected for further measurement. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Agilent 1290 Infinity CH:COLUMN_NAME Waters ACQUITY UPLC HSS T3 (150 x 2.1mm,1.7um) CH:SOLVENT_A 100% water; 25 mM ammonium acetate; 25 mM ammonia CH:SOLVENT_B 100% acetonitrile CH:FLOW_GRADIENT The gradient elution program was as follows: 0 --- 0.5 min, 95% B; 0.5 --- 7 CH:FLOW_GRADIENT min, B varied linearly from 95% to 65 %; 7 --- 8 min, B varied linearly from 65% CH:FLOW_GRADIENT to 40%; 8---9 min, B was maintained at 40%; 9---9.1 min, B varied linearly from CH:FLOW_GRADIENT 40% to 95%; 9.1--12 min, B maintained at 95%. CH:FLOW_RATE 0.5 mL/min CH:COLUMN_TEMPERATURE 25 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex 6600 TripleTOF MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Ion Source Gas1（Gas1）：60，Ion Source Gas2（Gas2）：60，Curtain gas MS:MS_COMMENTS （CUR）：30，source temperature：600℃，IonSapary Voltage Floating MS:MS_COMMENTS （ISVF） The raw data in Wiff format was converted to .mzXML format by MS:MS_COMMENTS ProteoWizard and then converted to .mzXML format using XCMS software. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Original peak intensity values MS_METABOLITE_DATA_START Samples NHP1 NHP2 NHP3 NHP4 NHP5 NHP6 NHP7 NHP8 NHP9 NHP10 NHP11 NHP12 NHP13 NHP14 NHP15 NHP16 NHP17 NHP18 NHP19 NHP20 NHP21 NHP22 NHP23 NHP24 NHP25 NP1 NP2 NP3 NP4 NP5 NP6 NP7 NP8 NP9 NP10 NP11 NP12 NP13 NP14 NP15 NP16 NP17 NP18 NPB1 NPB2 NPB3 NPB4 NPB5 NPB6 NPB7 NPB8 NPB9 NPB10 NPB11 NPB12 NPB13 NPB14 NPB15 NPB16 NPB17 NPB18 NPB19 Factors treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Control treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Placebo treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment treatment:Treatment Malate 48153.95899 81801.32767 496306.6504 54225.12226 93391.00552 88954.1934 94686.2199 869797.8274 140290.246 328217.3759 986800.8233 136906.3272 450282.6568 214650.7975 636953.2371 533738.7295 114363.209 342280.8165 676279.3324 44552.87426 119330.7258 4064.785389 101836.3577 107128.506 225369.5771 3529165.507 156441.6965 290792.6451 430267.3361 2369437.733 243515.926 3010598.596 2705227.529 95710.38457 39955.48781 1933200.397 311908.3911 1687816.204 1312937.752 69592.45419 1559197.695 366701.4625 2229035.854 106275.2032 378110.1721 330793.5913 3190149.528 116162.322 78014.42285 903143.9074 201112.8071 5143900.863 103977.8186 265135.8827 205524.6754 2367956.004 118873.0205 927433.4176 525158.5923 205209.7073 284534.2524 1177015.284 D-glucose 6-phosphate 10042.58954 5390.939842 87894.53722 7702.670688 33272.50331 22985.82108 34754.17156 93293.43574 110444.8143 68309.70353 73445.79237 13729.36302 29429.07404 17566.6073 20633.80324 29998.82993 27292.82637 14853.62167 40512.32284 7949.037914 5657.640007 5662.798922 4725.475006 8188.10278 28099.41579 300374.8029 555993.7996 40837.83363 65363.39012 106865.3107 109733.2297 29080.68374 612064.0635 38085.26996 2739.941269 129240.9189 46223.70928 133261.4155 40699.96274 49488.2486 474586.9466 5560.296376 382919.6833 8412.012176 56099.63746 18422.60824 778140.7854 20401.97921 42016.32777 118123.4761 10470.49724 27693.48938 9262.66574 36609.63288 67994.23146 100399.7249 38357.87315 8575.277226 626320.5577 38403.93523 30238.13404 26435.72806 Quinate 16638.79447 16962.48518 539067.2908 14016.26206 17709.04449 119731.166 18397.83955 249916.8629 128947.9197 306419.583 420652.1562 66750.71493 95228.05629 272954.8541 91123.4732 151440.595 98707.67967 46430.49179 72792.45528 30595.54782 26289.81978 4377.01135 109718.3676 31490.67193 216206.0372 2431643.296 194544.9857 204519.8397 75089.04988 569337.3936 878145.5052 391418.8729 2941093.227 56566.30906 16425.2609 242426.2363 161095.1388 1619292.266 635206.0827 26098.04759 1159192.775 459802.2435 1176603.852 19124.20454 91609.22116 87334.53857 1464039.388 51610.62727 79974.31271 131255.1387 45112.49907 393516.067 42877.67999 135401.4311 543488.2616 559834.2334 207868.8061 107567.2628 22131.8188 71168.21644 131644.9316 130796.053 D-psicose 31174.50772 19256.70369 82549.21669 96409.94716 58633.43938 27334.68865 33420.41879 17977.29266 30646.97319 68749.51661 131588.5293 40000.67742 99798.31472 57066.61022 160881.7829 201438.9841 186752.302 28544.45627 163351.3763 71364.94633 79531.23511 44753.34245 26132.74047 19699.39118 113781.003 67612.45749 152794.8764 296278.0201 212297.4937 141562.9086 390633.7816 604158.8735 285248.7164 99929.46969 14495.62979 565058.1438 151979.3826 1290840.822 62949.66985 39979.97099 347947.7829 72389.38123 645325.0974 38353.40222 67571.1471 33945.60986 103531.5035 58716.29791 24819.09325 1451492.887 273369.4416 148167.5117 153876.0203 105136.185 30500.89095 118545.1072 32272.86185 140376.6058 79480.01377 438306.8874 99526.15826 67296.44808 3-Methoxy-4-Hydroxyphenylglycol Sulfate 52051.99248 26707.7171 118163.3185 79296.29087 33232.22847 113041.524 156209.1663 115113.8088 121098.3516 236100.1788 161745.2067 197993.1104 425633.8265 27924.96852 185126.4442 137197.9012 135508.2924 109097.7922 42323.05864 81718.26174 120390.9575 71352.51006 28683.92988 29501.02191 1232831.938 128329.2784 194045.5403 167046.2486 49484.29189 1398853.655 1601011.774 1508877.815 167796.0557 85521.74302 56331.96684 1329177.445 212252.303 919453.0774 981652.3278 349119.7287 1282729.517 76917.29908 163812.2139 144452.7212 339783.6039 135661.3436 130919.4424 115347.8477 47512.92494 506395.5517 459560.1495 52345.82205 69885.15662 71485.91891 45773.99434 521485.0591 69811.80718 35372.93053 137144.3572 14228.42876 60893.54587 104038.1777 Fructose 1-phosphate 9512.894646 11740.29712 97244.03106 7498.343182 54735.03963 15949.99506 26554.83648 88347.62855 139898.3965 30140.96662 103900.62 15523.11939 64726.14835 11540.45854 31937.94514 123407.9382 179950.6619 92469.89168 92298.17819 8912.753469 16097.51174 12617.84958 15792.99075 22135.49383 48922.33454 160484.1351 279101.1945 48904.10596 32807.00924 168220.0747 110890.8684 173541.2532 321134.3761 45015.49134 33608.03331 495713.1877 59398.01066 625700.3434 54433.26938 105966.2782 176450.4705 13656.6917 247937.4752 14126.02523 21543.59328 187235.9629 400189.9594 52221.97656 244827.0198 380540.9189 87784.52923 35840.0966 18284.29887 38266.18814 56204.20309 316050.9188 25908.32658 26964.10873 378473.0408 3384855.384 19279.44772 90304.28039 3-Hydorxy-3-methylglutaric acid 29287.51725 21029.14726 317315.19 24648.72794 31952.19997 48225.91742 39835.07693 120894.2425 18978.71818 75943.1273 183629.8886 30821.46928 66557.9996 65090.27766 31707.34058 35332.53503 242169.5275 23877.9389 43627.31196 26333.77703 36045.494 4222.630513 25191.92199 15228.0498 93084.59514 565884.414 35992.66884 317630.5517 99362.65657 174996.2423 278074.5328 122212.4429 224193.8061 38129.64697 17749.16864 81541.88141 90119.33844 210306.9517 59859.0087 42376.75207 447849.97 162632.5355 469981.9442 41708.07377 41961.45701 25378.05352 531048.0887 188100.4713 15020.64994 175164.1394 107545.3645 51179.637 148066.1468 193264.9304 133388.6587 341779.4582 192136.1932 101257.479 49013.51681 43499.72255 99137.64144 194220.9121 2-keto-3-deoxyoctonic acid 16776.16978 68229.3756 122370.7877 23573.10133 50496.44068 23323.52962 20677.10013 80753.90777 78632.16068 88877.77748 141452.2262 145309.0741 128441.3741 34756.73376 10283.64566 26217.01912 53026.32096 8642.569152 29182.23952 10178.65424 34575.98878 3533.775303 12283.8888 23779.08115 60572.2718 174930.2741 131818.9367 97956.92102 119969.2597 174243.4785 54734.33257 306659.2406 211805.3111 13784.68436 10390.69747 196324.2515 57149.53761 135876.6233 91807.41205 32916.28834 77237.99504 60997.38847 101854.6332 30406.65872 25252.63055 35225.65818 100456.6117 48457.04038 40105.44886 125090.5964 91449.59154 79771.55458 21326.23971 53948.34406 85277.45757 56807.92548 109345.5129 13588.95743 22140.46533 11480.83832 38883.49232 52423.0405 Allantoin 12622.26528 869.6113466 50649.29005 2586.190818 7769.842754 4227.600434 8539.951102 68583.31521 6723.96454 52323.65218 57985.07139 17133.36779 107903.3093 6858.606781 1697.083034 6858.803395 24418.9435 8240.42067 92489.97848 8395.726565 8377.466397 6877.895096 7615.522807 9510.288291 60265.85158 105652.894 9477.798064 66987.74927 135384.5785 247743.0656 112126.0989 139654.1718 504378.6476 6498.291926 5717.505039 176560.1581 56490.96787 183280.3295 26094.90749 9840.435841 29659.5032 5516.244214 119254.556 5691.552948 6272.845658 2198.489069 94499.93005 7741.643508 9000.20822 6973.916588 35648.58687 11523.49982 7278.180142 38004.79012 11942.0575 148854.0776 10663.87454 6278.674064 6561.436677 6008.157149 15047.86848 343193.23 D-glucarate 33862.12398 3625.781464 326767.0725 3957.620965 370105.0955 9523.572331 5708.825539 180137.4781 149610.3307 456096.3024 488732.6648 164603.5545 89031.9185 13326.49524 10541.62843 10691.66297 5900.348504 18718.38952 116251.5497 3297.978473 13197.47891 3012.048814 3432.748228 13179.34754 123257.4498 1443629.708 207359.5504 5513.590202 117174.6288 1254843.668 197111.0728 530058.7136 490197.6592 24352.65664 3665.810259 184974.1979 51978.60271 802155.759 257129.4486 3523.416213 1154934.762 16179.45092 883137.3397 3142.834732 2254.993265 55585.45867 952421.4526 59715.7946 78147.90095 195642.9384 20981.97442 130327.4681 5410.562498 208907.5034 290619.5047 368271.9027 521103.4382 3489.871155 8889.855671 16598.11334 39291.75987 147447.7342 Propanoic acid, 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]- 31593.55686 17588.19658 51438.06885 13348.29747 12300.20135 37860.89439 42747.94472 31966.15204 31727.87277 119152.3733 62513.1073 37812.49014 159771.2226 15557.79709 52085.45378 53299.60449 62486.26073 18706.7412 58298.38075 12670.28211 21612.38976 1950.819813 6848.46174 9082.030236 57283.34658 24355.46235 25551.32855 88327.98238 52451.21299 242263.898 53949.87636 165486.3536 160048.997 41335.94674 8448.109657 199914.8182 135596.6579 112040.1679 36613.36611 54362.64188 84216.08828 49861.77888 461645.0963 33899.5559 27583.2446 96571.88097 29896.66875 50256.57716 137932.5676 98276.77652 39433.66431 197484.7394 27632.48391 9945.329015 95985.44736 78468.23439 31846.36782 49305.23112 3012.899906 85703.48129 18461.36313 52025.63221 Ethyl sulfate 28110.17019 1228.959463 143491.9642 6679.568984 6701.371057 1560.568431 2167.144711 74720.29602 56138.4823 33694.70458 49192.40163 64994.97262 22009.05024 2773.667829 8777.262217 15153.00242 279735.4614 26322.332 59429.19507 2285.27371 2663.035549 4410.087133 1316.489731 34655.9778 6768.127368 343881.8623 73537.80237 114020.8496 18391.91822 37960.17143 1592244.419 21851.87391 679205.3879 14612.90562 99647.78081 53535.65421 45769.3879 35546.88777 119526.1338 59123.78952 1153686.342 6605.288872 736944.2704 72100.33601 13970.01729 15040.55163 25852.28749 12478.67766 24733.61727 80818.96855 5061.54844 4696.575359 11988.56233 141809.365 58590.73309 69679.61983 11700.24857 6740.535749 1258.502997 4156.267913 10154.17306 9569.130037 Corticosterone 282561.5339 97165.81827 121214.5249 379783.4477 49043.29035 172549.939 81025.84466 63174.12233 10762.18268 99027.01669 146691.7403 242592.6822 172147.6383 212175.6678 89363.13424 103749.7523 23641.8553 108788.6624 77846.87427 342027.2308 64107.23401 28807.62766 49051.804 56187.90606 131225.6432 4637.97376 204638.4629 22300.58408 30135.24137 131398.1957 88853.60381 28664.21382 44872.35609 79041.53037 51132.41468 25855.51279 30538.98056 53142.67627 115462.2127 60578.21295 77622.68485 85790.39525 65739.0694 82579.63001 71541.4426 90471.34559 54661.89165 123069.7865 105100.4391 40018.20901 81423.33984 68124.43696 42860.25103 54412.11173 60498.20051 35835.89679 26782.00384 35622.56995 46940.1517 546543.9885 175522.778 14651.86922 N-Acetyl-D-Glucosamine 6-Phosphate 7799.312501 8963.604726 79320.61634 13942.02929 19367.39768 12706.6252 14102.70012 67583.86731 9286.702732 5405.481225 50167.75635 15348.37347 41572.75656 29298.79409 22092.99999 20214.00328 18846.26517 30635.63548 401430.1746 12752.49586 11942.63818 308022.86 7018.005131 9782.718566 933687.5796 18338.13972 12200.77303 15560.84522 12003.64091 2791236.575 736064.0418 500054.8434 2557.133168 522927.605 11012.79134 525677.2743 40115.501 916051.4457 2173204.412 3107.680816 711733.0264 217522.5646 9556.33835 18094.90963 341640.582 78759.49403 301671.3413 14728.90716 24075.69739 3909679.892 5065349.502 169802.0634 102768.4462 10854.49262 15082.70718 3780936.658 6287.949147 20609.87857 29856.90185 671815.6756 14793.71515 750546.3584 Silybin 30250.81038 9104.710217 21367.24576 27407.41674 15693.61501 22314.51572 18477.4161 16736.69678 27324.62689 17576.40618 26120.07488 12414.95872 797813.2625 22210.75409 20484.10222 16132.81115 465352.7871 106652.2341 28654.35741 12366.56631 6183.081302 20365.18626 14378.41774 8087.555389 731560.3657 30627.32928 15509.03027 10749.71088 20974.41318 770830.9951 1106154.438 3124115.219 37942.82425 35808.65128 8340.483674 4839108.4 249253.6697 2472928.192 539025.6133 5198.069392 913396.8222 11508.79385 37487.8734 63294.89332 715985.9772 81923.48009 71432.77993 21097.3144 8670.356423 500140.3635 3374331.458 11876.12078 23384.53163 14991.68167 7813.371705 1037896.802 4641.801897 418464.3111 5573.862666 9286.405895 16081.60317 211115.0606 Ostruthin 920473.9299 203599.7646 347126.4354 225306.2127 665977.4402 358369.1 136946.1105 1335247.14 551477.3734 264007.6258 619880.5659 332841.276 83558.09419 139017.948 129879.2815 244994.2596 80661.77685 175261.8929 119787.5717 292259.9008 115794.5075 169528.889 113858.7343 134336.5473 108819.7074 4014299.116 206001.5207 262563.4649 216822.1388 194102.5812 2270218.093 830364.5861 3039270.857 198281.8802 95277.62676 362803.2102 70091.46738 212499.4529 1187118.233 320614.0012 1606407.785 164647.3007 3749870.434 222789.668 154036.6667 566500.0504 3227439.257 456018.8753 71485.54671 232004.9263 84714.62023 159160.6967 233893.4976 3555562.816 4648725.491 1696031.058 2923809.237 130514.9735 198060.1203 202278.0121 904911.548 275277.8001 L-gulono-1,4-lactone 79747.43096 24759.74699 2375175.116 50633.76563 262897.4893 34290.77533 46483.9869 53042.77418 35407.02525 232874.1215 156457.7947 42983.12998 96982.59211 47900.23998 62155.56094 153705.6532 754029.4544 21280.65854 57348.84143 26396.85555 21887.71784 3957.817655 18247.29174 7629.373475 620704.1677 336781.1712 50764.83326 109109.707 72638.74198 7371755.675 3541756.194 272122.045 114150.06 61602.4109 205317.1122 202366.0034 248055.0038 130633.912 7781240.893 174825.0335 4251184.511 37829.09057 8719700.255 28691.14164 39118.12046 198363.4876 185376.4032 32821.86953 62624.72403 207430.9064 175826.0512 723979.1482 54310.89863 11002.50137 72996.33294 980998.8528 37814.87643 33188.02401 22941.80132 49707.96525 19802.67332 559504.2138 1-hexadecyl lysophosphatidic acid 14732.95052 39031.66982 26948.12946 26073.18544 16676.99886 10684.49695 3650.376695 142384.754 12088.48911 21050.39407 96007.61671 23640.72127 370527.8543 299628.0183 53949.92552 44335.74087 15521.40839 8525.5961 51405.69569 53685.68396 17216.44133 2089.889232 13660.26127 12605.00953 321166.5554 31356.37045 29864.28478 48455.31804 15713.76651 543008.4807 760209.3986 554545.5841 15709.80167 6351.594759 15567.5155 562339.9553 248771.6723 158524.0931 471135.0667 20391.86024 495983.9053 21908.89422 7072.961085 12097.88978 79177.93736 26261.01369 39371.51614 20524.63859 90479.98512 26809.72045 466614.8555 26724.25718 523513.639 11730.22138 14609.54362 108627.3945 16384.66245 79338.70339 7753.122288 330244.3857 21342.25314 104912.9131 D-gluconate 90811.27314 29533.55503 1276559.155 199105.8153 86600.22312 35067.62058 57506.91091 35030.35297 32263.12938 83514.20201 52464.30801 34125.1329 67497.57221 40331.93392 42477.50381 105468.4344 250504.6102 16619.98559 41386.79437 112665.0514 18926.20215 3299.47227 14132.97184 43654.99997 329040.5611 142133.3816 35904.71547 82426.85871 27408.47166 2161460.761 1030718.658 96928.96038 85525.05916 65088.54244 134636.9768 82510.54899 105883.6057 79367.58391 2274912.008 589074.5732 2185896.4 29929.52494 3530551.068 80180.85596 49127.19498 165899.5104 63135.30076 26455.25182 34848.57547 117276.2563 58010.61624 251293.8205 229749.263 9413.271898 62376.08021 493029.9656 39658.42021 40711.94758 21690.58285 41124.17566 28786.76562 187337.185 D-fructose 52969.34366 7155.032505 4332220.623 36539.31572 139259.5282 13759.61523 28428.7015 1086856.561 28858.87208 429522.5872 2218159.322 48200.728 314193.8873 89886.18003 98797.44537 113111.1672 98816.82577 64333.20083 87036.66703 15751.89477 29608.24105 2871.41979 31345.17596 123208.1875 340764.1517 6404749.322 116794.2488 62404.79516 88011.09813 1666966.308 2870450.267 1227225.208 2819267.692 27955.79748 15869.60534 485587.8778 242949.5252 2871578.696 465043.9439 23777.57515 7412133.146 153301.0192 5597368.869 30273.79254 51110.07183 147407.2437 7259113.429 59043.40613 13415.66583 383247.6701 56015.42646 227928.2526 49804.66524 667137.422 1227358.97 4502645.492 1911598.921 72313.62338 40513.3951 35365.539 633696.4166 1026877.909 Daidzin 19918.71753 6915.342295 11460.24055 31118.35808 9764.960669 17274.09646 28612.20133 15679.77235 9436.915618 14923.26734 47735.54595 4541.761059 172411.4101 60978.13664 44004.96819 22562.54684 70430.59325 77573.65926 75010.71219 26920.3373 16081.84943 17923.6839 8958.395253 3816.776069 252079.905 27091.71593 14150.4954 18988.56145 20169.81648 127072.4196 354197.2839 429295.4078 40739.58156 34915.74133 5100.614581 690360.892 53803.44162 291254.3237 86735.84054 5757.274333 290399.3328 19800.74626 47236.15517 10969.39454 159252.6733 39231.4249 57578.10052 17563.07619 14562.57737 619453.9202 87771.95791 46523.10407 14400.49413 10482.77463 5912.207117 189610.2489 5292.854377 39082.77062 30225.87713 431298.9553 14948.90165 129436.7805 D-fructose 6-phosphate 8906.334205 27592.12513 476903.7809 1126.863313 62805.81549 6410.254317 30750.82201 519148.3064 752179.1207 167717.3465 456846.5085 94811.13506 128258.2535 61403.42491 229913.9583 176383.5723 800119.4638 112035.5592 279874.8282 37721.95569 18720.57726 35486.05524 24452.85021 47982.41747 162613.8257 731965.4846 2366289.381 297447.675 304691.647 500252.4644 646743.5181 230781.3551 1325738.029 25592.92747 8065.858306 70795.46398 81992.09183 191910.0533 178753.2274 566492.1732 970834.4683 38797.19899 2007949.221 22505.45744 56973.78603 58417.60884 2138900.57 464819.1482 251772.5261 425965.8726 9948.873486 158723.6913 26436.92676 156808.156 122437.2439 219353.8962 85354.98209 4452.794426 1416331.386 40294.63655 86658.54054 92707.88002 Glutamic acid 25205.25124 19183.58966 337264.1171 36261.50313 75505.67335 16239.19924 21268.64076 26065.59837 27684.53414 61989.28688 147403.0216 180689.5608 410291.9444 33867.71411 75566.90007 127506.5338 224103.2545 10658.96673 123725.5645 89845.35761 2544.35924 2260.230753 7427.028265 4932.604322 193829.5797 164747.3651 129858.0149 122311.3431 51717.49731 1351130.753 349428.3371 307950.629 3931325.982 41803.07979 103484.7264 223539.382 234936.2724 129376.8623 889679.6758 3017950.29 572696.0106 86163.96156 39500.63194 16129.15879 18977.84754 30507.46896 94510.79153 31098.37263 89095.31037 84494.18645 54439.86106 97634.97057 262627.2924 39616.3201 125177.6036 184059.7244 170680.9484 13383.46583 15254.75226 72296.85855 21881.66628 379047.859 Mestranol 83458.06639 81914.89706 220339.0652 122833.5315 134720.087 121854.2144 142036.7319 1126331.792 332430.9179 139724.7558 421978.4778 424334.4954 60305.70807 92515.19864 125380.867 181201.7373 26492.23859 79237.14421 79390.49143 79968.11172 33274.24407 130446.4463 73680.57296 69327.02125 88903.83693 3994069.116 165442.4601 229576.2625 84801.70556 89218.28913 1141056.397 418227.1732 2748512.164 118969.6989 67121.07801 202721.3584 62617.60342 223811.07 908898.5556 354249.3343 681369.9193 109719.9761 4403487.284 82075.75961 87909.89325 285533.8028 3541953.936 106115.7459 56477.42183 86170.44636 43307.6731 23607.97561 109204.5088 5777015.065 5011616.409 2287202.818 2538801.947 29773.8649 64686.58369 113044.4014 1130060.166 106238.4762 6,8-dihydroxy-2,2,4,4-tetramethyl-7-(3-methylbutanoyl)-9-(2-methylpropyl)-9h-xanthene-1,3-dione 38355.59845 41959.81401 68186.57183 81961.21033 238941.291 54509.80467 19200.10776 257840.899 112436.5493 13841.59415 118872.4984 98529.93107 47715.29756 134882.805 27671.28841 38206.81479 14108.73618 27309.42765 24618.321 240049.2118 63731.97949 16375.50015 21704.76946 25290.97006 55934.80904 478187.5355 142153.3478 139274.5551 149379.1533 30914.61403 334735.7085 83835.66825 348859.3471 102719.6733 106527.0377 36982.30706 59218.70838 37412.74481 145252.2233 61147.47143 256305.0225 36616.16275 456159.2271 31835.009 22957.65077 53955.96436 385899.6323 165698.9172 10548.55721 24873.07273 59339.80903 33968.88252 42246.6324 586883.7761 619713.2616 221337.8603 381917.1224 122908.3527 145493.4238 32022.25462 135358.2001 45594.2447 1-palmitoyl-2-linoleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) 191587.7361 381821.5347 49977.34162 48121.79247 18091.48134 19925.76369 50814.39166 137549.0177 86205.54243 78504.74977 69543.90555 59545.84633 254982.019 97866.22128 54655.87291 44325.36985 32462.17194 77788.74007 77490.00191 36387.96769 30724.36254 19652.61461 42271.95321 111177.9366 193302.0403 53060.51215 488790.236 40192.34821 38427.91825 364293.7066 658293.0032 510180.5998 30453.09267 35278.36801 37019.68989 461683.7497 133503.3845 118536.8127 352502.5016 50229.67503 471962.4398 24630.23681 4825.798906 59037.836 81862.68998 338307.3114 78629.63243 16696.73978 109288.7752 39052.34916 271031.4997 63536.51161 509336.2605 23730.17436 59299.24751 194754.3701 17811.97107 80911.97131 23547.42847 938438.7846 100006.5388 130381.4798 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide (aicar) 7463.079347 10465.54677 31012.79294 6870.480743 16099.4799 11192.44585 16931.574 9536.99856 9656.456169 9941.369661 6316.25775 13330.83045 3783.201749 7683.020726 10375.28361 4284.795783 11849.13608 7252.623213 11470.92445 4553.564901 7462.896875 2018.458753 10517.8074 10487.605 14637.29745 46704.32701 13071.3795 3750.580514 17266.56395 414138.7099 11842.76055 62884.78703 33025.66761 11392.7583 7433.072601 37275.20893 7543.607745 5026.117931 124696.0673 8320.465664 490577.9771 23127.72848 760626.3782 10447.82611 13440.59943 5900.293772 35233.90821 5130.803983 4099.160233 11037.58494 4546.789256 84493.87606 9701.301404 10297.79458 12449.73274 171376.4641 16266.19986 8028.11699 9871.915992 3958.792022 8385.23332 39342.01541 Daidzein 4'-sulfate 8186.614387 6880.736991 4417.461202 23827.62405 7532.784666 12493.74018 39101.47135 6400.918993 4801.791119 37181.21022 31119.72804 16216.07133 963699.0157 15065.30312 47762.22827 24557.98768 12836.51732 22787.12928 27244.34515 121292.8702 24500.26911 24163.58512 6556.219803 21209.08303 916024.857 5944.057608 17965.59795 4437.356321 20437.37547 47800.48546 2071044.281 1991334.138 93845.99374 18872.62858 13746.22159 5120342.525 101971.6433 3134657.462 42123.70957 15665.25491 1759798.921 10726.48145 80601.99252 13772.90065 344285.9689 3407172.861 39758.37289 65703.79785 27903.89739 943560.8587 2409483.921 15833.38462 12651.94413 27178.49091 15317.45178 2227606.179 6330.213176 14390.59258 8612.786248 984300.6423 12708.68733 38895.02707 Thymol-beta-d-glucoside 348050.0491 833460.088 1252235.101 1101858.447 1665164.64 980594.5603 482453.1618 6535212.085 2120936.218 878716.2906 2311792.31 1235476.342 318159.9197 409482.417 742459.9559 913339.2765 393634.2565 683321.3053 457754.5113 777032.4873 391186.96 695059.1841 387738.7303 508326.6676 350753.2437 22589580.59 749122.2701 831088.3223 513989.5591 728463.3054 6213801.624 2687795.377 15532059.38 682375.862 364756.6416 1079731.971 150762.2637 748310.8686 5846788.729 1400723.487 4262691.728 604926.8497 25450765.32 737902.23 481232.3837 2448838.293 17409421.07 1520546.449 322062.0387 922717.0716 299399.1934 479450.9662 768008.9816 29687938.74 32338231.6 12056366.67 17892918.47 452987.4143 634632.8856 832309.5032 5770642.672 786294.1665 Biocytin 133615.1234 77594.78179 2654118.739 514897.3448 472995.5896 727357.674 389667.116 155909.2354 997974.453 366381.5639 421997.029 167632.1928 1751476.011 2541951.42 2228023.676 1941300.551 2743540.902 1488679.636 7467720.79 251644.1217 620708.8646 395149.813 1169265.784 1057088.468 108970.622 610021.805 196061.4891 535887.6608 721231.8864 61612.71313 897678.7395 56087.64843 79629.72005 434562.6221 294367.1888 62985.20984 412391.8707 441090.6707 97030.43949 266202.6013 707760.7319 519193.8456 1404902.526 123888.5776 544730.3522 1078464.097 815017.0451 958750.1793 363449.2676 2943916.804 1573796.283 2130914.164 1688431.752 334706.578 138476.547 251359.6231 518413.9273 5221250.475 1422921.312 927950.3005 2039216.785 757561.8582 .alpha.-keto-.gamma.-(methylthio)butyric acid 39275.89898 15258.44731 221809.0751 9084.347788 233168.8355 12081.21564 14451.33718 17631.42755 68137.92312 6840.724167 69129.65413 105194.5215 21131.24129 10567.70493 28937.31904 28690.24799 2332.221151 2653.838529 81011.73411 104186.4525 124518.2039 6135.907071 51712.90368 16393.81267 158330.4663 101075.6879 37305.37706 59113.5904 11035.25929 64957.39908 495645.8387 168136.349 49114.73198 30677.82276 12917.69164 291538.5082 139769.1637 72063.74558 85879.97274 246514.9963 137915.3434 531008.0846 63014.75543 9625.058645 65849.11088 18407.39286 135497.8365 15803.32547 59396.27453 53961.3489 69666.01056 32696.90798 18362.06073 81152.99719 124143.2978 229264.0064 31917.72994 451.7667816 11957.07004 40446.07325 48075.34091 8551.974075 1,2-propanediol, 3-(1,3-benzodioxol-5-yl)- 105568.7782 20887.74567 842617.1014 66798.59479 71680.27065 36164.68514 52182.10724 26321.43517 16754.92463 58137.32032 39748.20806 27842.74518 35628.12189 23539.93085 24804.52057 63545.30808 186626.343 17831.14699 30456.1732 30142.89056 17661.18674 4969.497896 15624.33906 48890.12497 437766.2782 81381.43816 31125.83979 68371.96485 22307.00811 1169752.611 663702.9523 53679.43679 46664.38908 54052.02914 112828.0183 76354.0616 100308.5417 36470.32937 1256677.071 169902.0147 1136524.281 22110.03445 1456787.975 22501.91568 44907.88903 169919.8709 37602.83888 25837.9825 29513.94846 84870.71216 37638.28015 124156.6424 69981.19182 9096.781272 55521.33954 273642.6124 24074.73108 24770.16935 21408.70273 17186.94537 24478.42613 156282.2789 Nocardamine 3930.324503 61791.08898 9652.385251 10885.11521 34566.55656 32261.09534 14167.94158 15438.17253 5640.379517 29531.96386 53764.34998 10205.19559 195369.1846 81227.93641 30262.87641 31991.53363 114223.4025 30574.82877 100724.3216 4566.435349 9812.006339 1656.709111 9088.178394 3844.564289 49495.75421 18329.05746 15471.63557 18690.89139 13943.11014 268600.0995 785914.8761 2200945.888 6798.536451 154612.2006 15646.0313 1849073.907 70516.43715 123024.4605 256548.6828 1335.004154 345218.5707 7398.284326 6324.404806 12546.4051 101672.6567 42397.21709 4603.162606 4487.256919 36723.28628 94274.68638 65542.00805 582883.3621 66459.61997 5597.230556 10807.91727 111962.3637 7640.299826 135972.1246 14854.69851 124742.5586 11052.98457 31629.36107 Indoxyl sulfate 7178.037259 1504.719328 10410.43116 4433.266286 8649.259193 1125.692148 2709.871854 36468.87404 23688.8066 38343.56605 27058.48182 25968.86462 22860.12146 3870.141543 10690.42116 12423.93445 23870.21218 2023.870726 10513.43481 3181.084437 8632.651557 53545.05764 2358.834796 31329.42414 1033225.611 28489.0113 21470.42056 32068.78751 47353.5639 251580.3396 2224715.999 8846553.297 1119633.458 7120.882171 7020.931544 4384450.528 76010.44687 727606.2363 184595.9103 388.9334629 1713635.62 4505.443807 22773.10794 4058.893111 342708.0858 549729.8293 85234.22244 12407.15517 821.9820202 60759.31782 14651.9481 141170.8278 4223.145555 23742.60682 190525.1798 398572.6194 11437.04469 7640.437022 2713.122161 792649.5568 5210.891535 10606.01183 Demethylbellidifolin 140397.6177 37343.42168 267795.1845 87029.91078 14635.10092 79311.87132 5284.433622 421007.7867 537664.5478 169948.1199 252485.2566 150713.5321 147561.022 53810.76552 167144.961 177080.2889 1148565.619 73653.73042 647327.2424 104347.5639 26856.00781 106505.0436 51812.18565 70906.91293 246768.518 1188401.548 514592.166 809820.6493 459577.4674 637690.6412 328173.3375 543125.5994 2447846.609 88617.95902 89004.29787 96645.87625 78226.2642 349281.8471 248103.5895 156746.5676 180843.2796 46543.78465 975652.9074 59237.09615 261208.0284 176755.1053 1278193.284 66778.27534 204072.5915 88494.06578 169144.391 286970.2944 644797.7853 558330.9509 123624.2468 298785.9478 195436.242 134138.3937 226916.0092 29744.46106 205616.7677 316178.0863 6,8-diprenylnaringenin 70738.10732 12322.54432 118781.4715 15297.77819 60558.37621 37049.47368 452111.645 158462.6472 148247.2282 57174.90569 127570.726 283524.1536 159855.5371 213639.5636 26555.17847 60634.98661 105715.8859 68695.90738 16818.93038 59463.33244 30475.20268 14867.24412 9237.480539 10493.66681 13428.01862 367563.657 251445.2446 272584.0777 100465.9918 112846.0062 150286.7336 130024.2317 364923.4124 48455.14633 30496.43122 103602.3597 65566.57301 222843.6037 114019.6473 272364.7606 89554.64558 113510.7882 346587.4952 35972.08862 52987.34485 68602.56229 295490.1058 28218.5757 7872.818259 33609.4728 2145.884941 94641.56851 121474.6596 228303.9604 239856.2024 168794.8543 237712.4101 47791.21557 25985.98809 61998.86158 359777.8577 85001.31344 5.beta.-androstan-3.alpha.-ol-17-one sulfate 314740.7543 246645.9985 1626797.075 459211.0984 1068119.782 4234234.516 1970903.116 1624114.389 3242837.462 805226.7764 741457.9417 626810.2387 4330764.492 20602619.68 8831758.609 7062027.845 11671850.78 12272637.41 21067798.38 577838.8273 2892468.362 1333815.65 8675798.588 10186849.98 435889.1697 919362.2265 499023.6037 4355540.675 9233256.478 258943.4909 3421362.138 606948.5073 394722.2455 2447714.396 415052.6427 795500.8221 3385433.87 1170525.722 298522.0785 886215.8573 2927977.362 3521158.037 1693735.525 220740.9083 3132676.123 6407660.148 2113975.87 2254056.676 3646478.366 13166485.38 5432178.632 7072972.372 14320268.45 1262885.861 183172.6224 2104754.073 868414.8641 17599464.86 9356280.179 5531829.241 3156879.446 2725537.869 Citrate 186331.5556 102318.2298 231663.1843 124650.5397 60413.14983 256961.8955 346085.09 99341.47414 131229.3833 1062250.258 361372.6326 260842.0896 1439231.069 102562.1654 594831.4334 502429.4128 514489.0599 86132.44144 338748.6079 64385.68134 45155.58004 2764.88561 18202.53743 32806.99306 370156.0914 131786.052 136208.1334 697352.2965 382162.8784 1954035.003 293283.5892 1084125.294 1212552.313 171415.8058 80652.17933 1530522.447 195464.0433 717321.5046 192294.9566 369930.7744 441778.0512 317359.2892 3682860.56 158826.6129 179282.671 789491.518 149085.4264 373591.423 1278581.142 773109.3788 65047.64959 1822959.498 151865.4879 70949.22791 444707.368 457235.9955 46002.63714 243932.7885 11999.45658 531841.8293 185947.8674 222312.7789 Hydroquinidine 453015.7049 930052.3959 1396751.689 1175303.425 1856753.582 1178578.749 459127.5024 4975129.389 2209513.947 925885.9183 1796011.02 1051654.158 297024.6426 362805.1612 902034.5706 1147145.472 530277.2241 735877.6563 593607.1215 817472.6816 476903.9916 864903.5542 456496.1009 551837.5512 435266.9199 24794305.87 828449.6858 647176.492 546817.1605 978753.7491 3871858.005 1733655.389 14940859.38 660095.3029 400566.0477 988688.5316 236524.1919 653790.981 4714174.469 1253220.611 3168777.458 669105.7072 27742047.62 837095.3175 526205.5031 2781964.962 17522784.63 1909286.251 400967.6588 1155864.28 334532.2762 564372.7185 813794.943 28994329.7 36220580.6 13061788.82 20250237.48 560754.002 750668.1097 988880.7549 7122350.942 893111.796 D-glucono-1,5-lactone 9073.620592 8929.339692 113696.3127 5949.867198 84805.1307 9853.644625 13888.38826 232525.0516 11611.74616 42204.78549 137514.2086 34432.17981 133205.0458 12317.53967 16363.24596 16916.70934 29544.87801 13116.0162 69697.30095 11535.60137 6823.865294 6158.574253 6357.694806 7167.233306 122848.8881 2929497.028 27002.59051 30726.43965 45441.73965 248379.3619 137584.8407 693967.1447 398139.8701 19014.47097 7465.797091 303991.1028 37198.93939 157514.5286 113038.5327 15757.64457 442743.6523 26657.67914 785051.9811 9389.334689 12144.52662 22780.902 1583967.705 29533.17356 12477.65248 109635.7301 21872.89006 265611.757 12264.15522 103041.6155 158211.5261 339607.2864 122466.4414 14330.04628 10972.24747 20186.77038 30300.53956 68268.25436 Propionic acid 1429293.803 19895.23609 1003470.266 1752798.371 1142303.121 543927.4593 1142693.644 752025.9057 245852.3816 2054098.643 1592017.934 914013.6724 1949721.005 962474.188 839613.2218 892964.4909 16036.79105 725619.6023 671652.8137 1371016.693 484449.4418 271546.792 291268.0967 884941.6252 1435738.421 779074.4491 622092.8871 48671.31858 1317356.474 838974.1123 73610.68258 415082.2762 496506.3887 2085507.98 20113.22515 507702.4012 1151805.368 746081.4137 648340.7802 11897.69488 60485.54663 589040.183 856612.959 24349.85539 625002.8771 2039401.504 1124614.616 2076415.934 1123373.665 1440525.795 1085587.111 1161748.978 17156.99692 443447.2188 181996.1363 474049.7361 451332.0139 469909.8995 1342568.986 356633.0975 1000450.156 592100.1377 Aleuritic acid 6486.37148 7904.277321 32313.46748 7845.481541 335138.4538 26319.75212 8521.105453 339080.7058 53823.71436 50257.19295 108268.8053 35472.96587 13829.67576 38712.54094 19289.67363 69139.97395 80884.0855 45786.94042 33514.38698 109279.0914 7088.145115 10958.4494 6523.882349 16519.75671 7490.171366 5677334.244 53505.67434 50259.59004 138684.4033 9000.128279 288915.3342 165691.1259 2522423.415 552653.2526 29459.86321 21730.37751 17518.278 67843.92327 348599.5402 100377.9827 107270.2539 21980.58704 6927950.636 53106.79539 43575.55433 255131.5811 2149970.572 157898.8947 29068.53658 139916.5451 19149.86039 98126.53825 79323.63334 3669854.827 6749127.095 3052330.638 5022349.335 97689.70712 96342.07398 67560.47549 863721.6637 18763.03707 5-(1,2,4a,5-tetramethyl-7-oxo-3,4,8,8a-tetrahydro-2h-naphthalen-1-yl)-3-methylpentanoic acid 429376.5877 14198.21699 56127.2405 6763.598624 59255.56584 61357.81029 30060.63228 437237.0004 220064.5233 26598.48577 138435.9873 214920.6031 35308.29859 80141.74678 84556.45113 82023.47196 32785.75288 74988.5702 46597.13351 163755.3055 116561.6089 64049.60563 28797.08521 37714.19093 29321.81094 3458045.933 151115.0469 73359.19335 23221.91167 41160.19847 227597.1694 82894.34751 2222591.428 132334.3023 34192.89482 14413.74894 12159.79027 541744.5601 199451.8369 125456.3914 67176.5844 100174.2784 3469001.077 19555.95342 31070.84353 174035.2658 2297451.076 70150.82155 60963.46303 41082.13696 26663.49048 45795.38219 143988.3686 5769552.27 4472313.868 1265728.525 3352065.419 30253.92079 83352.93143 86247.54106 1028436.906 17349.75331 1,2,3-benzenetriol 56174.56495 20460.56968 97230.55118 11224.74023 29383.20043 7259.053174 16893.12662 3385.38538 50044.38287 65266.99342 6381.111692 1503.861248 39459.0196 7558.38007 13154.13556 24641.38411 208973.9975 18156.28341 721.9334119 26250.08091 8135.743685 5068.006547 6774.846081 23417.49922 24287.67544 113448.1577 10708.53703 89762.63537 38625.36887 3057.586088 6514.04644 62821.79953 412862.3486 6924.615544 74870.24053 92294.20249 43550.23166 103752.7512 59786.98188 53493.95538 645562.8553 11662.03382 31829.89384 64316.74358 9468.473465 20143.66541 5992.2684 53717.76154 191131.7485 44524.18864 3764.3643 7971.840129 21434.93705 72550.99813 29806.60349 37746.17076 14601.8929 12596.53354 5020.535627 27122.6598 11270.20783 9890.089322 Pe(16:1e/15-hete) 63531.56278 175258.2121 87910.8526 264848.3012 67620.92893 47853.61706 45541.85029 657263.1918 57933.24495 187585.5812 256138.3241 51164.49464 595341.1343 181466.8929 81401.32619 87216.55054 59266.25272 106095.3167 63880.0437 54499.75851 47089.21381 28876.69802 50019.8929 74181.50916 237037.7556 106125.0027 92642.13212 3105.247734 21693.34088 352312.4994 868691.5544 953622.1988 18382.98131 31019.49408 136557.5621 612942.9972 441881.5203 448157.006 515082.5371 124741.1679 625217.9294 24160.0423 26749.41236 97408.54664 211326.9523 92806.85515 57675.47546 68627.98919 73852.45561 37874.49298 1554829.392 49884.95143 808173.5019 38250.68741 31327.86912 150810.1948 45144.67647 79848.83183 54595.36115 2601484.501 49422.34903 133941.8134 Gly-His-Lys 358743.5891 591936.7814 1094609.741 771647.4521 1329600.059 880702.19 417903.9282 3385616.584 2050991.453 698866.1432 1206031.126 794349.3319 265936.4194 296224.537 841376.0593 1038359.377 592827.4369 735939.8872 582702.8656 669871.952 407345.1488 772804.385 393889.7376 490871.3545 370168.7091 19121209.58 683691.1967 414741.1179 417103.9099 786848.7892 2039608.934 1013825.086 11171365.74 607092.7506 305285.3823 616776.8867 198124.9305 563762.871 2756391.376 720558.0666 2017814.512 564099.2266 20069953.86 766367.3705 480706.8515 2342631.452 13396561.33 1718594.404 386778.2327 1178293.4 306562.8023 442447.3131 684091.5024 21754509.43 26354180.06 11001497.74 15417541.72 532505.124 686657.0171 879079.7164 5386830.765 589974.2951 Lpe 18:2 26925.94769 25844.18926 29872.00975 39138.81338 16679.01855 29650.22296 17536.07167 129119.5558 22215.93238 49789.37589 315914.38 29363.62298 3391479.645 112108.7659 87521.55694 97684.08147 44235.14285 26854.09572 52159.66282 47739.53966 29645.04235 11716.49633 13309.67113 15430.21818 513958.0013 25653.58714 45937.67604 21873.70897 34774.92967 2439617.261 5224586.498 256626.8603 22200.49153 18230.72824 6139.419113 309368.1252 200801.4645 2066137.486 2312556.923 107431.0663 6867672.914 16955.16642 16405.97096 40484.11655 138929.3947 130667.3775 71024.03152 70885.4577 57969.63433 86957.20339 2282457.866 177037.2964 603364.5742 21906.71139 17833.38634 1093028.531 19568.6089 43492.30558 48768.46189 3085705.33 29364.73383 150938.5199 D-lyxose 19414620.03 617163.7295 5615379.964 17730430.38 23955497.97 1540030.365 4494264.324 332845.0943 5820521.286 20415440.41 8507320.395 29098444.54 551547.1643 602672.5935 795276.923 1092337.581 333666.8363 1568944.962 1111505.537 252313.8706 370375.03 3055143.389 575371.1575 7001733.329 235205.4901 3955672.872 7764275.112 49401.9497 4128339.795 628456.8591 1425037.685 64385.04656 3723255.634 9894756.136 357082.1674 28289.11295 1123117.765 2003909.982 1220950.655 101066.6421 115469.0171 1225319.423 7075594.715 172943.7692 194037.0565 5411583.739 5052400.313 8593602.608 1297641.56 4279159.887 1281377.413 511507.4211 207840.596 3234938.624 2404058.402 983655.6669 5159973.446 503423.9453 4725244.661 434164.0626 1560251.606 554919.3793 (1r,3r,4s,5r)-1,3,4-trihydroxy-5-[(e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxycyclohexane-1-carboxylic acid 17645.62179 12807.03756 154715.202 5793.592445 60942.29498 28362.84733 25292.69079 66652.19524 13565.79707 11641.38553 360149.2717 32581.33099 60135.99211 53633.92671 8719.526134 18786.0662 146173.5864 24521.50643 45677.48918 23545.02231 14562.71657 2839.904812 74770.62453 3897.767437 57668.82427 4616749.526 23976.05723 6152.798434 24666.58232 175657.8062 237667.948 384313.0481 1046519.197 23770.7319 22437.26769 199155.1744 20790.24221 133549.4106 157260.5918 25344.25647 650384.9017 26227.23038 1309603.889 21551.77983 43316.00074 52042.90679 3971749.834 40077.86159 85527.02498 98888.4256 38138.07665 231343.4608 41026.37702 60763.49816 330480.98 489785.025 620669.8251 45566.16832 20863.42781 137015.9266 69085.94893 284086.9485 Dl-lactate 16675.87727 103123.9489 1193016.131 141461.7582 437872.545 41284.96628 71320.39832 232340.1654 850871.5984 1942361.719 2565035.275 160046.3728 1463949.425 38467.94982 100718.1309 83447.21587 35459.29021 69843.14744 2132401.182 39100.36021 50690.54902 5622.611586 14821.96638 51793.20562 1530799.989 319200.3936 114784.1028 38195.59382 1625026.863 1096166.038 3294161.386 1018824.848 6120958.599 51588.27 22564.37325 1252140.044 259315.6042 5563486.024 256411.019 151132.5318 2598135.73 296859.1582 1912060.468 30489.76121 12762.17184 126388.2727 9805770.019 495888.704 189937.2742 307624.2656 221345.8327 663231.0359 26258.74288 437139.1637 263184.2928 913563.874 565706.8232 39919.03488 26239.00376 1353751.625 47000.22102 1028586.974 Dl-malic acid 1371.8154 14914.21034 1916988.98 11127.75503 49434.43748 8034.849835 8807.656116 67700.24188 528071.9315 72981.69591 61570.07861 158927.7672 95559.04049 203842.3017 7068.130993 8612.972244 16818.53795 1285.122996 81410.11912 13791.42856 1863958.374 6978095.252 4041443.843 3738947.486 319530.0706 132325.1476 49392.06482 489272.312 18596.71664 95376.0321 34130.37881 749.7302346 383968.7641 783.2276835 2808.536632 177142.6749 98924.2116 3500.019032 2052.952343 2485.341449 5125.672924 186405.2316 3686.870141 21037.6098 9755.609355 855.0365514 19964.62703 10556.45082 7570.750943 11582.19573 2874.536142 50532.96252 16104.92683 210982.1706 93193.07329 1879.862216 1399.589523 4464.880795 1343.947336 24854.95711 71243.22986 747511.9241 Pristimerin 793687.0018 2162230.162 523960.4582 936597.0478 1211738.9 944221.3615 516278.1234 194948.5877 395513.4095 600359.4844 2021804.282 485234.065 334312.7979 468803.9137 643432.1986 592318.9796 601572.9534 196841.8946 304105.7466 643696.5173 303237.0896 63009.03579 234527.1321 360330.233 311629.4512 200628.2154 496688.946 315855.424 460229.9673 349118.6476 328284.457 130820.5443 358126.0921 639056.9727 729639.9341 122963.5598 283396.6826 183187.7749 324505.0714 838555.8266 342569.093 663421.0774 318070.387 648002.0006 352414.2304 208560.8032 213480.8811 218514.7547 221472.0761 329730.9814 281981.1223 469662.3144 533072.7121 324791.3678 528513.0687 221468.5597 696670.2352 662391.8366 332783.4419 271760.7032 336287.2758 719562.419 2-linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine 65222.53467 145531.8315 73614.41598 149426.4307 31725.78057 23087.76312 34951.10452 918912.1066 21310.1027 40293.50994 201867.2472 20021.26693 594013.3494 279188.7747 112068.8049 119297.4616 40150.41436 131825.2389 61861.61658 20619.26968 266236.3306 56642.13242 113951.457 57986.27235 415295.9887 166587.9551 34002.18231 53956.59932 23285.70822 473572.2029 1614597.952 779816.0628 27075.87516 24773.2468 131293.0347 512020.3785 330401.4206 258278.4265 664021.5446 129569.3146 1577970.674 27422.20094 17570.55151 40863.35389 293815.2493 92940.01702 41859.87044 58974.86124 115893.306 39091.11117 1130666.285 81470.87281 2489299.511 41051.8843 32358.80896 176950.261 39918.2487 79769.05077 41630.08212 2371761.856 31061.76139 132394.4767 1h-indole-3-propanoic acid 896694.6549 96028.93138 524733.9452 730672.296 324005.3838 109362.7857 178011.9964 112025.0763 86504.07419 568871.1492 194261.2401 155535.5659 340860.6306 134234.4082 2483.445921 11147.78858 867872.4359 501979.0836 384501.2501 141545.5225 70800.57508 750157.2032 119422.4555 1085031.661 580898.7901 526318.8537 318433.8293 119815.0923 159975.1267 248420.6966 71866.7125 2676.411431 81600.21722 98434.80149 355277.211 4963.155003 1072547.198 174893.274 171294.7708 125954.8418 26487.85196 151541.5928 98010.12066 204413.818 7166.906544 364194.4336 75256.83195 276789.9032 338053.165 200334.85 208091.5519 145073.4899 115504.9776 272254.015 57545.7561 181417.2586 263050.3502 125261.0108 598063.7305 272101.1221 114963.9419 178719.1139 Homovanillic acid sulfate 12950.26136 6985.044009 34289.7738 10263.05012 12045.24686 13235.23568 17634.28716 65524.24269 46388.59532 30673.72312 45718.51018 22521.59145 2462756.831 37600.45241 44841.79158 14451.08571 77441.62796 994225.1026 437872.8293 18100.77927 13926.26607 649253.225 26202.26023 117422.7453 3960065.456 31117.13817 132010.2198 35784.35418 32700.54369 51444009.18 6548307.443 492213.4231 101817.5387 13820.82918 15639.72322 385794.6262 1442726.31 17180853.8 13350632.63 40496.08177 3991524.114 11387.1802 143947.2689 11255.95316 285915.4557 1494481.365 123649.9403 72733.61646 116216.3661 11104952.76 4593143.421 1050835.193 12268.56197 35379.09025 18512.29882 3173741.134 19873.48424 14081.66636 12052.77224 3604868.612 24858.51365 1182261.905 Polydatin 23674.65963 14045.66345 22544.57865 26437.31014 20894.78864 30254.69817 57243.33712 33555.22872 9990.327231 47026.4072 25975.46115 19146.42823 11837.48655 52468.8921 87222.23437 77736.11874 31263.68966 158553.8261 19814.74112 41789.41548 13459.28694 66956.76731 14502.93177 16223.12053 2108593.308 49587.32615 32031.76614 23588.90097 49436.18421 1222924.014 408850.7161 421291.9412 54483.07301 38321.98873 16454.07536 779327.5393 341087.2147 4147212.561 874968.1175 17292.71238 521861.5445 17093.97393 59406.13201 22102.54891 830134.1633 98633.61736 32942.18724 50464.11521 16007.62674 362488.2534 476751.941 137143.4844 12806.02049 13683.63873 23972.82798 612693.2266 18133.44256 63964.32484 33355.03416 302901.6046 27122.78285 289884.7114 Taurocholate 8754.28022 37874.72319 26686.83215 9986.831507 20003.01757 138226.1498 19437.81945 7236.509 1876.09639 29120.59633 23147.18957 27739.31987 120967.5179 19792.94472 41737.96389 67588.083 195053.369 144903.8693 388208.5224 15947.28136 10025.80052 27236.93028 4811.219897 8367.409562 98322.92442 10834.12241 75513.33192 17477.67032 10698.7631 280262.4937 154085.0824 15312.59964 9855.601101 14440.52547 11361.44273 29612.32941 935707.4984 142436.4546 207439.3015 16429.78339 191144.8676 9625.532542 6793.417383 4255063.096 5555153.46 341852.1114 19604.1259 12827.8828 67623.14922 161418.4133 93394.47504 554336.9364 108358.2312 11846.14684 9684.790212 54024.70436 194415.8462 183584.152 17116.3222 183906.6035 12116.92445 47676.43223 N-Acetylmannosamine 41092.02895 12048.73589 263869.7753 95162.27588 1202765.29 39475.18715 119951.4326 24735.96641 80180.03751 415342.4862 325696.439 108341.1041 132562.4805 141762.2653 81419.71915 59081.58038 81105.55649 111030.2914 174098.4976 12189.7686 89920.44786 3694.6647 26284.53996 22175.02726 264810.0773 756512.8921 102222.2098 49017.03922 164766.5601 597492.9547 97050.28954 423754.7589 42771.18424 525931.1011 8309.937737 422220.2071 129225.5327 1622850.845 343352.837 9428.896143 560835.9171 522824.3781 45829.53502 11327.85063 75444.83486 173226.8729 263634.6034 54095.40369 146522.5342 484099.2766 90844.36751 179996.604 88320.43423 40568.43458 37429.83567 1426749.897 221773.5082 151266.508 73902.82963 491911.7504 38653.38319 119549.9908 Glycerol 2749.934054 2161.63399 1786.902612 2749.409937 1265.609355 2650.6378 1053.291296 3508.076727 2374.116254 5311.465641 5111.444765 2227.772042 6279.833723 1657.826582 334600.3471 412.7005665 1997.585671 3309.90124 3610.500109 3546.284775 1785849.604 4912275.46 3033480.498 2935490.632 6345.105883 4207.524958 1599.934067 180.3859569 792.4814183 3874.363996 48360.23569 1611.515243 938.9499285 2988.636497 9112.497145 2790.587982 214.9748273 8117.125094 5038.764317 4544.214403 9885.375244 239.8241874 1174.707959 296199.1603 1406.589241 4055.560568 2365.80198 1821.808434 23699.51002 327.0150436 3018.595188 99.05022478 1131.000023 7439.667828 1765.368937 5594.08414 9039.009042 1997.585671 2076.494065 2420.133552 3751.164952 1366.231263 Zinniol 337375.0125 227668.298 1604584.105 535985.0377 282604.2985 414069.5159 341705.199 2312508.643 810428.4049 437660.3996 1622327.571 688820.0711 741016.2572 1182344.404 615145.1053 817616.9224 156829.4725 1106185.265 1209604.229 254473.6598 626828.7972 507265.8957 279231.2011 250265.5723 379145.5147 10010567.17 541493.0269 414750.0662 173241.9887 465870.2484 2604644.725 1666595.878 4207639.652 191135.3163 213200.5096 1181524.44 661467.0051 1441431.03 2358508.229 391723.2062 1115434.739 209867.4154 2140167.918 180622.2624 506854.5205 2482831.301 11623358.87 1606070.788 307314.0749 1383053.497 831380.8751 266403.4404 675545.1115 6869190.282 9763062.406 7117638.4 5249048.751 1062934.151 5399747.002 3008225.268 2462002.82 1071762.696 .beta.-hydroxypropionic acid 26870.89625 35442.13457 344597.5217 204258.8277 128447.7208 22291.67427 23408.91912 138433.5317 53865.84839 157588.7479 647056.1659 89558.1545 290829.7232 52972.73 93835.58332 80970.46717 115169.4061 54645.3465 221014.8902 23457.49498 23284.69728 17563.68871 184347.3515 41252.84643 146235.0152 1165449.749 47288.68048 26998.07598 157377.6928 342271.0347 334535.6995 66257.46702 142087.4247 43020.27178 91716.93964 162198.281 223124.8692 1103370.069 166876.4338 148393.4325 452646.504 68070.95939 272610.7484 17875.33177 70324.66075 158471.9238 713343.4754 150862.9043 55356.89113 259900.7802 226885.2033 171360.3285 223324.1122 168958.2917 159194.1138 665292.0289 466753.4114 137423.1267 106299.236 216119.3182 94867.93754 160518.9141 Pyruvate 7297851.473 720088.3803 4797355.817 7885758.579 6358002.622 1802789.799 6571857.408 2487868.018 2373783.834 13411961.21 7575501.093 5776458.659 4527913.714 1885480.928 4493601.969 6149631.139 948335.565 3986846.35 7123055.38 3131543.789 1336624.97 1214746.357 1411588.257 11023760.17 7410524.726 1474429.517 6068760.645 111302.7754 5139934.198 6250801.712 1210531.498 3332274.756 958676.2618 7534105.795 3483342.051 5660169.396 3081775.568 3585644.557 4338610.733 288378.7785 870200.3443 568576.7612 5779640.23 2883142.104 4475495.014 10789202.75 3330978.375 8465637.523 8187628.195 4947962.803 1598546.66 879438.6582 1419782.82 1016937.932 367805.0614 2730118.117 1321515.821 1831054.553 7502348.873 8401392.306 4064174.569 3631291.442 Glycocholic acid 7950.209565 85105.37971 53578.59147 23684.66342 23107.12671 570870.8667 8513.531375 18321.5565 6552.637196 43336.23579 59141.84265 39877.27826 50776.28995 43670.7258 26195.87073 38123.76567 124259.8007 18187.75445 65035.39528 35775.49902 24133.36191 2775.784774 4987.85909 6583.428078 73443.30671 6121.127869 183268.6267 17736.82072 14579.15692 202278.4043 66277.75365 19435.87208 16225.73057 22608.52808 3877.226609 67737.08097 3449977.32 111063.5502 104967.7993 13950.90452 113763.4537 9859.740635 12136.62774 14507750.18 6978608.775 215557.7211 16618.27631 14020.74055 67261.17703 63963.24712 47141.90665 131186.9185 14062.45489 23677.14215 3719.325295 43676.54547 331591.1478 16334.49193 18379.06852 24030.76255 14753.60603 17377.60216 4'-demethylpodophyllotoxin 6895.823181 5165.54327 119132.8241 4155.157542 8559.296595 10495.945 14574.0243 2689.30466 3602.119382 19648.43184 3923.646401 7652.466906 6785.562022 8725.641783 1243.503904 8586.139297 25628.41234 5824.574899 4053.896202 44556.17152 656.8830461 2287.552611 3697.858696 3645.81668 7802.028453 4690.88403 7072.145552 10669.07976 15174.97876 548202.1628 88544.23878 7077.162702 3874.807148 12628.00493 1134.864043 4856.443507 4307.004465 1806.805625 233328.1667 4080.240704 751003.2774 31870.23041 2447876.934 16101.81261 17235.93755 7920.147167 14942.37363 31402.0969 1973.66889 12921.84267 3901.917634 5234.57785 10517.24414 6627.504714 4371.049394 100223.7862 7266.601279 14355.21474 17677.4318 4104.786543 7766.00848 3860.739302 Succinate 88279.76513 37932.91565 559066.1823 43293.90773 844795.8701 48050.5377 17131.80163 160778.3687 30870.4087 140027.2984 434816.5358 668632.7747 2147101.505 93706.17078 21202.14826 20561.37671 53746.29227 46346.49654 55863.34345 47125.03773 17286.84069 12536.14075 31254.21209 9824.244454 468432.5021 222091.6451 117507.3422 467774.413 157388.4139 2213091.698 392785.9953 703507.1618 491910.8097 41231.81784 108086.0122 498895.3295 314284.4904 1576550.244 632425.0458 280320.0501 368060.5485 76273.67302 1489286.173 41575.95268 116526.3313 193047.8798 131626.7057 23747.17435 375196.935 173959.7261 1438258.951 240263.7772 233480.5893 72990.88317 354729.5421 437438.1895 469900.6436 24988.7789 33991.622 174460.0667 235599.6847 896797.67 Sinapic acid 55661.71868 41555.90126 169612.3485 23945.04751 50262.5154 84966.1806 3355.147922 22032.71445 82794.40629 21473.77715 226281.4349 55335.44148 132836.5248 23747.36885 48109.6836 41300.6718 54688.22629 13698.6011 44374.24198 30438.64134 44501.96838 18701.90464 17694.01578 27601.94308 45720.64995 179000.3297 47533.17581 32934.1828 50241.97749 15022.48225 157228.5562 121689.5801 234886.9337 30515.64519 25206.40026 118653.4589 26340.06916 212225.2552 183277.9784 24890.23779 350191.2571 27438.76725 1556558.271 43351.84576 22525.12426 35652.95031 281452.8816 66298.22573 38306.86017 95764.49145 86937.71302 40404.66187 22153.42117 26797.95487 15997.36794 102248.162 23251.23648 69517.63523 9532.345299 36292.72038 61743.03351 57509.64078 Hippuric acid 4715.316683 3152.628836 4602.149483 3183.985451 3912.059448 7632.422047 3499.403328 7253.96254 18134.70174 5963.271076 3443.676536 5906.318665 5492.072719 6143.183362 5432.838897 6937.325183 29816.12008 5962.720673 16386.62929 4328.188837 2484.234714 2427.209666 2124.213715 2862.004681 34348.24047 3661.71601 5454.551179 4408.203961 7080.688854 27966.83686 93789.70145 3885709.661 198633.8731 6027.500472 5722.287562 2170289.012 7054.97336 202551.1481 27661.58815 3449.240928 68317.19378 5351.385358 4931.968895 1753.829176 6598.51517 13478.72016 3921.31502 9137.699154 3441.763424 17889.91553 4105.408529 604.4230479 3999.484554 2787.463921 105964.4877 219667.7675 2615.481329 48641.16864 3601.402866 37466.63279 3128.056095 7472.661884 Cis-4-hydroxycyclohexanecarboxylic acid 16507.65321 20836.34938 16637.49378 100510.681 11112.68749 21021.96377 102049.7006 49827.77473 7243.81359 55358.76582 35541.23903 249113.4808 672746.9288 43521.06894 33453.27071 36502.76925 12502.40699 514965.0413 1805716.179 4710.615104 8807.837848 25339.83906 25183.03678 14260.77073 3842958.079 14867.70576 47192.40637 21057463.52 58061.29206 4480639.103 453037.5956 4255651.169 26258.8802 124357.9217 28013.05035 4082855.906 267543.8827 287879.2029 3346729.964 42446.8044 382246.9798 189701.4888 20146.8699 30156.76232 33851.49137 439688.5851 203908.2255 17145.6832 182841.3892 1421333.382 395023.5695 178389.9424 25312.60583 32121.75872 22553.06881 1929148.694 16548.58351 12717.93972 507592.8604 1769180.606 4661.444436 3236153.788 Alpha-ketoisovaleric acid 50183.84456 175996.3702 660333.1518 160084.8258 1914319.736 285697.3606 158797.0924 213903.2051 76313.32706 1123056.393 511685.3959 380844.3315 481120.2199 368325.4207 165867.5959 208304.5015 11134.47211 140729.8214 163950.1952 451221.9226 1331604.089 180323.4121 712779.9033 548805.1186 542965.9394 2325078.758 92820.97603 461820.9666 579841.2424 1810456.677 1513416.755 262158.4461 288838.1254 130723.3506 312830.3194 43545.27391 346838.2415 74483.54209 1069437.849 1181178.211 1785701.62 5946001.754 124654.2819 250385.8289 101017.3335 295986.2613 316969.4517 87504.68283 45825.89489 81081.69921 488653.4751 398020.8264 494540.2887 259587.351 1136654.8 402489.7251 2425568.719 19973.32847 190099.9954 31603.59194 882829.0603 803983.8175 D-allose 155302.9342 29182.85221 3869995.824 2150983.006 560979.0784 54529.89817 210445.5133 1766338.814 234908.4215 801707.7424 7419734.916 687523.4691 3327636.205 532541.8429 1164442.02 1081865.262 1692177.611 512937.2592 1747766.269 111350.8687 89834.79529 13192.86012 85331.62373 92731.21775 1681550.602 10286278.97 458614.6967 188306.0688 213782.6407 5521518.412 1377418.297 211124.0301 621354.0495 282351.75 990506.6033 123209.1686 3636348.734 14682347.96 1852132.63 1834379.563 6891320.133 163171.2624 3119286.934 192124.5561 660925.1282 2336885.929 7203818.949 765441.2889 590752.0878 3201539.234 1567100.007 2044436.207 3051520.893 1025829.96 1571403.896 6294722.732 2771677.771 1348277.754 1054407.783 2043583.313 692870.4745 1936167.755 3.beta.,7.alpha.-dihydroxy-5-cholestenoic acid 26553.93724 43644.0469 46878.55943 43573.9464 58813.57275 96886.63885 151711.6959 30281.18419 74573.77211 52343.92589 460955.8433 64538.3584 116140.5305 18527.44402 18634.96252 54758.98496 95951.17136 43215.80444 31083.34955 78506.29398 25637.67436 23067.50517 24719.75728 79537.92071 34556.85467 43995.61976 90334.82664 25061.67919 42136.28876 75624.90326 87025.60907 802416.7665 66662.82752 481828.8356 51057.18247 432521.5584 35162.27563 26348.77842 305318.9762 97987.26618 68591.09226 85595.46871 46576.56964 37141.06914 48400.90961 49104.76784 61805.62124 85227.00267 78649.86399 20557.5967 55570.3302 25063.22203 24734.68174 133545.3181 57243.74434 44835.11542 56743.0721 45057.03616 55854.80936 70631.20489 52957.67022 145442.1842 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Malate D-glucose 6-phosphate Quinate D-psicose 3-Methoxy-4-Hydroxyphenylglycol Sulfate Fructose 1-phosphate 3-Hydorxy-3-methylglutaric acid 2-keto-3-deoxyoctonic acid Allantoin D-glucarate Propanoic acid, 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]- Ethyl sulfate Corticosterone N-Acetyl-D-Glucosamine 6-Phosphate Silybin Ostruthin L-gulono-1,4-lactone 1-hexadecyl lysophosphatidic acid D-gluconate D-fructose Daidzin D-fructose 6-phosphate Glutamic acid Mestranol 6,8-dihydroxy-2,2,4,4-tetramethyl-7-(3-methylbutanoyl)-9-(2-methylpropyl)-9h-xanthene-1,3-dione 1-palmitoyl-2-linoleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide (aicar) Daidzein 4'-sulfate Thymol-beta-d-glucoside Biocytin .alpha.-keto-.gamma.-(methylthio)butyric acid 1,2-propanediol, 3-(1,3-benzodioxol-5-yl)- Nocardamine Indoxyl sulfate Demethylbellidifolin 6,8-diprenylnaringenin 5.beta.-androstan-3.alpha.-ol-17-one sulfate Citrate Hydroquinidine D-glucono-1,5-lactone Propionic acid Aleuritic acid 5-(1,2,4a,5-tetramethyl-7-oxo-3,4,8,8a-tetrahydro-2h-naphthalen-1-yl)-3-methylpentanoic acid 1,2,3-benzenetriol Pe(16:1e/15-hete) Gly-His-Lys Lpe 18:2 D-lyxose (1r,3r,4s,5r)-1,3,4-trihydroxy-5-[(e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxycyclohexane-1-carboxylic acid Dl-lactate Dl-malic acid Pristimerin 2-linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine 1h-indole-3-propanoic acid Homovanillic acid sulfate Polydatin Taurocholate N-Acetylmannosamine Glycerol Zinniol .beta.-hydroxypropionic acid Pyruvate Glycocholic acid 4'-demethylpodophyllotoxin Succinate Sinapic acid Hippuric acid Cis-4-hydroxycyclohexanecarboxylic acid Alpha-ketoisovaleric acid D-allose 3.beta.,7.alpha.-dihydroxy-5-cholestenoic acid METABOLITES_END #END