#METABOLOMICS WORKBENCH nmatulionis_20230925_123530 DATATRACK_ID:4332 STUDY_ID:ST002878 ANALYSIS_ID:AN004716 PROJECT_ID:PR001761 VERSION 1 CREATED_ON September 25, 2023, 3:20 pm #PROJECT PR:PROJECT_TITLE Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy PR:PROJECT_SUMMARY Mounting evidence supports an instructive role for metabolism in stem cell fate PR:PROJECT_SUMMARY decisions. However, much is yet unknown about how fetal metabolism changes PR:PROJECT_SUMMARY during mammalian development and how altered maternal metabolism shapes fetal PR:PROJECT_SUMMARY metabolism. Here, we present a descriptive atlas of in vivo fetal murine PR:PROJECT_SUMMARY metabolism during mid-to-late gestation in normal and diabetic pregnancy. Using PR:PROJECT_SUMMARY 13C-glucose and LC-MS, we profiled the metabolism of fetal brains, hearts, PR:PROJECT_SUMMARY livers, and placentas harvested from pregnant dams between embryonic days PR:PROJECT_SUMMARY (E)10.5 and 18.5. Comparative analysis of our large metabolomics dataset PR:PROJECT_SUMMARY revealed metabolic features specific to fetal tissues developed under a PR:PROJECT_SUMMARY hyperglycemic environment as well as metabolic signatures that may denote PR:PROJECT_SUMMARY developmental transitions during euglycemic development. We observed sorbitol PR:PROJECT_SUMMARY accumulation in fetal tissues and altered neurotransmitter levels in fetal PR:PROJECT_SUMMARY brains isolated from dams with maternal hyperglycemia. Tracing 13C-glucose PR:PROJECT_SUMMARY revealed disparate nutrient sourcing in fetuses depending on maternal glycemic PR:PROJECT_SUMMARY states. Regardless of glycemic state, histidine-derived metabolites accumulated PR:PROJECT_SUMMARY during late development in fetal tissues and maternal plasma. Our rich dataset PR:PROJECT_SUMMARY presents a comprehensive overview of in vivo fetal tissue metabolism and PR:PROJECT_SUMMARY alterations occurring as a result of maternal hyperglycemia. PR:INSTITUTE University of California, Los Angeles PR:DEPARTMENT Biological Chemistry PR:LABORATORY Heather Christofk PR:LAST_NAME Matulionis PR:FIRST_NAME Nedas PR:ADDRESS 615 Charles E Young Drive South Los Angeles, CA, 90095 PR:EMAIL nmatulionis@mednet.ucla.edu PR:PHONE 3102060163 #STUDY ST:STUDY_TITLE Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy. ST:STUDY_TITLE Dynamic Labelling experiment. ST:STUDY_SUMMARY Mounting evidence supports an instructive role for metabolism in stem cell fate ST:STUDY_SUMMARY decisions. However, much is yet unknown about how fetal metabolism changes ST:STUDY_SUMMARY during mammalian development and how altered maternal metabolism shapes fetal ST:STUDY_SUMMARY metabolism. Here, we present a descriptive atlas of in vivo fetal murine ST:STUDY_SUMMARY metabolism during mid-to-late gestation in normal and diabetic pregnancy. Using ST:STUDY_SUMMARY 13C-glucose and LC-MS, we profiled the metabolism of fetal brains, hearts, ST:STUDY_SUMMARY livers, and placentas harvested from pregnant dams between embryonic days ST:STUDY_SUMMARY (E)10.5 and 18.5. Comparative analysis of our large metabolomics dataset ST:STUDY_SUMMARY revealed metabolic features specific to fetal tissues developed under a ST:STUDY_SUMMARY hyperglycemic environment as well as metabolic signatures that may denote ST:STUDY_SUMMARY developmental transitions during euglycemic development. We observed sorbitol ST:STUDY_SUMMARY accumulation in fetal tissues and altered neurotransmitter levels in fetal ST:STUDY_SUMMARY brains isolated from dams with maternal hyperglycemia. Tracing 13C-glucose ST:STUDY_SUMMARY revealed disparate nutrient sourcing in fetuses depending on maternal glycemic ST:STUDY_SUMMARY states. Regardless of glycemic state, histidine-derived metabolites accumulated ST:STUDY_SUMMARY during late development in fetal tissues and maternal plasma. Our rich dataset ST:STUDY_SUMMARY presents a comprehensive overview of in vivo fetal tissue metabolism and ST:STUDY_SUMMARY alterations occurring as a result of maternal hyperglycemia. ST:INSTITUTE University of California, Los Angeles ST:DEPARTMENT Biological Chemistry ST:LABORATORY Heather Christofk ST:LAST_NAME Matulionis ST:FIRST_NAME Nedas ST:ADDRESS 615 Charles E Young Drive South Los Angeles, CA, 90095 ST:EMAIL nmatulionis@mednet.ucla.edu ST:PHONE 3102060163 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 9 AK15-D9-B-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D9-B-01.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-B-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D9-B-02.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-B-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D9-B-03.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-B-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D9-B-04.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-B-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D9-B-05.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-B-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D9-B-06.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-B-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D4-B-01.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-B-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D4-B-02.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-B-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D4-B-03.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-B-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D4-B-04.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-B-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D4-B-05.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-B-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D4-B-06.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-B-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D3-B-01.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-B-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D3-B-02.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-B-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D3-B-03.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-B-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D3-B-04.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-B-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D3-B-05.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-B-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D3-B-06.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-B-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D6-B-01.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-B-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D6-B-02.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-B-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D6-B-03.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-B-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D6-B-04.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-B-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D6-B-05.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-B-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D6-B-06.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-B-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D7-B-01.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-B-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D7-B-02.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-B-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D7-B-03.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-B-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D7-B-04.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-B-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D7-B-05.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-B-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D7-B-06.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-H-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D9-H-01.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-H-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D9-H-02.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-H-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D9-H-03.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-H-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D9-H-04.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-H-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D9-H-05.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-H-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D9-H-06.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-H-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D4-H-01.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-H-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D4-H-02.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-H-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D4-H-03.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-H-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D4-H-04.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-H-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D4-H-05.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-H-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D4-H-06.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-H-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D3-H-01.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-H-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D3-H-02.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-H-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D3-H-03.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-H-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D3-H-04.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-H-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D3-H-05.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-H-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D3-H-06.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-H-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D6-H-01.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-H-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D6-H-02.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-H-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D6-H-03.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-H-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D6-H-04.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-H-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D6-H-05.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-H-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D6-H-06.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-H-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D7-H-01.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-H-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D7-H-02.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-H-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D7-H-03.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-H-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D7-H-04.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-H-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D7-H-05.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-H-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D7-H-06.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-L-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D9-L-01.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-L-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D9-L-02.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-L-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D9-L-03.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-L-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D9-L-04.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-L-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D9-L-05.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-L-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D9-L-06.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-L-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D4-L-01.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-L-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D4-L-02.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-L-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D4-L-03.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-L-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D4-L-04.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-L-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D4-L-05.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-L-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D4-L-06.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-L-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D3-L-01.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-L-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D3-L-02.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-L-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D3-L-03.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-L-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D3-L-04.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-L-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D3-L-05.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-L-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D3-L-06.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-L-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D6-L-01.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-L-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D6-L-02.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-L-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D6-L-03.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-L-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D6-L-04.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-L-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D6-L-05.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-L-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D6-L-06.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-L-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D7-L-01.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-L-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D7-L-02.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-L-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D7-L-03.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-L-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D7-L-04.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-L-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D7-L-05.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-L-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D7-L-06.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-P-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D4-P-01.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-P-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D4-P-02.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-P-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D4-P-03.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-P-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D4-P-04.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-P-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D4-P-05.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-P-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D4-P-06.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-P-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D9-P-01.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-P-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D9-P-02.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-P-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D9-P-03.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-P-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D9-P-04.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-P-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D9-P-05.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-P-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D9-P-06.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-P-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D4-P-01.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-P-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D4-P-02.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-P-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D4-P-03.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-P-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D4-P-04.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-P-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D4-P-05.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-P-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D4-P-06.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-P-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D3-P-01.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-P-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D3-P-02.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-P-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D3-P-03.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-P-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D3-P-04.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-P-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D3-P-05.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-P-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D3-P-06.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-P-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D6-P-01.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-P-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D6-P-02.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-P-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D6-P-03.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-P-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D6-P-04.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-P-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D6-P-05.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-P-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D6-P-06.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-P-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D7-P-01.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-P-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D7-P-02.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-P-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D7-P-03.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-P-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D7-P-04.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-P-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D7-P-05.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-P-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D7-P-06.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-S-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D4-S-01.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-S-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D4-S-02.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-S-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D4-S-03.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-S-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D4-S-04.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-S-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D4-S-05.RAW SUBJECT_SAMPLE_FACTORS 4 AK15-D4-S-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D4-S-06.RAW SUBJECT_SAMPLE_FACTORS 8 AK15-D8-S-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D8-S-01.RAW SUBJECT_SAMPLE_FACTORS 8 AK15-D8-S-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D8-S-02.RAW SUBJECT_SAMPLE_FACTORS 8 AK15-D8-S-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D8-S-03.RAW SUBJECT_SAMPLE_FACTORS 8 AK15-D8-S-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D8-S-04.RAW SUBJECT_SAMPLE_FACTORS 8 AK15-D8-S-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D8-S-05.RAW SUBJECT_SAMPLE_FACTORS 8 AK15-D8-S-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D8-S-06.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-S-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D9-S-01.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-S-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D9-S-02.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-S-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D9-S-03.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-S-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D9-S-04.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-S-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D9-S-05.RAW SUBJECT_SAMPLE_FACTORS 9 AK15-D9-S-06 Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=AK15-D9-S-06.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-S-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D4-S-01.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-S-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D4-S-02.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-S-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D4-S-03.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-S-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D4-S-04.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-S-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D4-S-05.RAW SUBJECT_SAMPLE_FACTORS 4 WT15-D4-S-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D4-S-06.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-S-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D3-S-01.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-S-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D3-S-02.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-S-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D3-S-03.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-S-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D3-S-04.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-S-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D3-S-05.RAW SUBJECT_SAMPLE_FACTORS 3 WT15-D3-S-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D3-S-06.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-S-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D6-S-01.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-S-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D6-S-02.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-S-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D6-S-03.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-S-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D6-S-04.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-S-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D6-S-05.RAW SUBJECT_SAMPLE_FACTORS 6 WT15-D6-S-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D6-S-06.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-S-01 Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=WT15-D7-S-01.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-S-02 Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=WT15-D7-S-02.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-S-03 Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=WT15-D7-S-03.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-S-04 Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=WT15-D7-S-04.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-S-05 Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=WT15-D7-S-05.RAW SUBJECT_SAMPLE_FACTORS 7 WT15-D7-S-06 Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours RAW_FILE_NAME=WT15-D7-S-06.RAW SUBJECT_SAMPLE_FACTORS 10 AK15-D10-S-01 Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes RAW_FILE_NAME=AK15-D10-S-01.RAW SUBJECT_SAMPLE_FACTORS 10 AK15-D10-S-02 Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes RAW_FILE_NAME=AK15-D10-S-02.RAW SUBJECT_SAMPLE_FACTORS 10 AK15-D10-S-03 Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour RAW_FILE_NAME=AK15-D10-S-03.RAW SUBJECT_SAMPLE_FACTORS 10 AK15-D10-S-04 Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours RAW_FILE_NAME=AK15-D10-S-04.RAW SUBJECT_SAMPLE_FACTORS 10 AK15-D10-S-05 Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours RAW_FILE_NAME=AK15-D10-S-05.RAW #COLLECTION CO:COLLECTION_SUMMARY Healthy wildtype and Akita dams were set up for mating. The following morning, CO:COLLECTION_SUMMARY females displaying vaginal plugs were identified as pregnant, recorded as CO:COLLECTION_SUMMARY embryonic day (E) 0.5 and moved to a new cage until the appropriate embryonic CO:COLLECTION_SUMMARY day to be interrogated. CO:SAMPLE_TYPE Embryo #TREATMENT TR:TREATMENT_SUMMARY Pregnant mice were placed under a maintained plane of isoflurane anesthesia TR:TREATMENT_SUMMARY (2.5%). Retro-orbital blood draw for time zero was performed followed by opening TR:TREATMENT_SUMMARY a small incision to the lower abdomen of the pregnant mouse to expose a single TR:TREATMENT_SUMMARY conceptus for fetal tissue harvesting. Immediately after the first blood draw TR:TREATMENT_SUMMARY and fetus collection, a tail vein catheter was placed and bolus (4 µL/gBW) was TR:TREATMENT_SUMMARY administered followed by continuous infusion (0.085ul/gBW/min). A single TR:TREATMENT_SUMMARY conceptus, accessed via the initial small incision, was harvested at multiple TR:TREATMENT_SUMMARY time points during infusion of the nutrient tracer (13C glucose). Retro-orbital TR:TREATMENT_SUMMARY blood draws (<20 ul) were taken throughout the infusion to monitor tracer TR:TREATMENT_SUMMARY enrichment in maternal blood. Timepoints for harvesting after time zero were: 30 TR:TREATMENT_SUMMARY minutes, 1 hour, 2 hours, 3 hours, and 4 hours. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Fetal tissue extraction: Following infusion, mice were euthanized and blood was SP:SAMPLEPREP_SUMMARY collected via heart puncture. Fetal tissues (placenta, brain, liver, and heart) SP:SAMPLEPREP_SUMMARY were dissected in ice-cold sterile PBS. Immediately after dissection, weight was SP:SAMPLEPREP_SUMMARY recorded and fetal tissue was placed in a pre-filled bead mill tube containing SP:SAMPLEPREP_SUMMARY metal beads and 500 µL of methanol:water (80:20) solution kept cold on dry ice. SP:SAMPLEPREP_SUMMARY Fetal tissues were homogenized using a Fisherbrand™ Bead Mill Homogenizer. SP:SAMPLEPREP_SUMMARY Samples were spun twice at >17,000 g (4 °C) to remove precipitated cell SP:SAMPLEPREP_SUMMARY material (protein/DNA). Supernatants were collected, transferred to a clean SP:SAMPLEPREP_SUMMARY tube, and evaporated using a Nitrogen evaporator (Organomation). Evaporated SP:SAMPLEPREP_SUMMARY samples were stored at -80 °C. Pellets containing protein/DNA were dried on a SP:SAMPLEPREP_SUMMARY heat block (55 °C) and stored at -80 °C. Serum extraction: Collected blood was SP:SAMPLEPREP_SUMMARY centrifuged at 5,000g to collect serum. Serum was snap frozen in liquid nitrogen SP:SAMPLEPREP_SUMMARY and stored until extraction. For metabolite extraction 5 µL serum was mixed SP:SAMPLEPREP_SUMMARY with 500 µL 100% MeOH (-80 °C). Samples were centrifuged for 10 min at >17,000 SP:SAMPLEPREP_SUMMARY g (4 °C) and 450 µL of each sample evaporated using a Nitrogen evaporator SP:SAMPLEPREP_SUMMARY (Organomation). Evaporated samples were stored at -80 °C. SP:PROCESSING_STORAGE_CONDITIONS On ice SP:EXTRACT_STORAGE -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Dried metabolites were reconstituted in 100 µL of a 50% acetonitrile (ACN) 50% CH:CHROMATOGRAPHY_SUMMARY dH20 solution. Samples were vortexed and spun down for 10 min at 17,000g. 70 µL CH:CHROMATOGRAPHY_SUMMARY of the supernatant was then transferred to HPLC glass vials. 10 µL of these CH:CHROMATOGRAPHY_SUMMARY metabolite solutions were injected per analysis. Samples were run on a Vanquish CH:CHROMATOGRAPHY_SUMMARY (Thermo Scientific) UHPLC system with mobile phase A (20mM ammonium carbonate, CH:CHROMATOGRAPHY_SUMMARY pH 9.7) and mobile phase B (100% ACN) at a flow rate of 150 µL/min on a SeQuant CH:CHROMATOGRAPHY_SUMMARY ZIC-pHILIC Polymeric column (2.1 × 150 mm 5 μm, EMD Millipore) at 35°C. CH:CHROMATOGRAPHY_SUMMARY Separation was achieved with a linear gradient from 20% A to 80% A in 20 min CH:CHROMATOGRAPHY_SUMMARY followed by a linear gradient from 80% A to 20% A from 20 min to 20.5 min. 20% A CH:CHROMATOGRAPHY_SUMMARY was then held from 20.5 min to 28 min. CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Thermo Vanquish CH:COLUMN_NAME SeQuant ZIC-HILIC (150 x 2.1mm,5um) CH:SOLVENT_A 100% water; 20 mM ammonium carbonate, pH 9.7 CH:SOLVENT_B 100% acetonitrile CH:FLOW_GRADIENT Separation was achieved with a linear gradient from 20% A to 80% A in 20 min CH:FLOW_GRADIENT followed by a linear gradient from 80% A to 20% A from 20 min to 20.5 min. 20% A CH:FLOW_GRADIENT was then held from 20.5 min to 28 min. CH:FLOW_RATE 150 µL/min CH:COLUMN_TEMPERATURE 35°C #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME Heather Christofk AN:OPERATOR_NAME Nedas Matulionis #MS MS:INSTRUMENT_NAME Thermo Q Exactive Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS The UHPLC was coupled to a Q-Exactive (Thermo Scientific) mass analyzer running MS:MS_COMMENTS in polarity switching mode with spray-voltage=3.2kV, sheath-gas=40, aux-gas=15, MS:MS_COMMENTS sweep-gas=1, aux-gas-temp=350°C, and capillary-temp=275°C. For both polarities MS:MS_COMMENTS mass scan settings were kept at full-scan-range = (70-1000), MS:MS_COMMENTS ms1-resolution=70,000, max-injection-time=250ms, and AGC-target=1E6. MS2 data MS:MS_COMMENTS was also collected from the top three most abundant singly-charged ions in each MS:MS_COMMENTS scan with normalized-collision-energy=35. Each of the resulting “.RAW” files MS:MS_COMMENTS was then centroided and converted into two “.mzXML” files (one for positive MS:MS_COMMENTS scans and one for negative scans) using msconvert from ProteoWizard. These MS:MS_COMMENTS “.mzXML” files were imported into the MZmine 2 software package. Ion MS:MS_COMMENTS chromatograms were generated from MS1 spectra via the built-in Automated Data MS:MS_COMMENTS Analysis Pipeline (ADAP) chromatogram module and peaks were detected via the MS:MS_COMMENTS ADAP wavelets algorithm. Peaks were aligned across all samples via the Random MS:MS_COMMENTS sample consensus aligner module, gap-filled, and assigned identities using an MS:MS_COMMENTS exact mass MS1(+/-15ppm) and retention time RT (+/-0.5min) search of our MS:MS_COMMENTS in-house MS1-RT database. Peak boundaries and identifications were then further MS:MS_COMMENTS refined by manual curation. Peaks were quantified by area under the curve MS:MS_COMMENTS integration and exported as CSV files. If stable isotope tracing was used in the MS:MS_COMMENTS experiment, the peak areas were additionally processed via the R package AccuCor MS:MS_COMMENTS 2 to correct for natural isotope abundance. Peak areas for each sample were MS:MS_COMMENTS normalized by the measured area of the internal standard MS:MS_COMMENTS trifluoromethanesulfonate (present in the extraction buffer) and by the number MS:MS_COMMENTS of cells present in the extracted well. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Peak Area MS_METABOLITE_DATA_START Samples AK15-D9-B-01 AK15-D9-B-02 AK15-D9-B-03 AK15-D9-B-04 AK15-D9-B-05 AK15-D9-B-06 WT15-D4-B-01 WT15-D4-B-02 WT15-D4-B-03 WT15-D4-B-04 WT15-D4-B-05 WT15-D4-B-06 WT15-D3-B-01 WT15-D3-B-02 WT15-D3-B-03 WT15-D3-B-04 WT15-D3-B-05 WT15-D3-B-06 WT15-D6-B-01 WT15-D6-B-02 WT15-D6-B-03 WT15-D6-B-04 WT15-D6-B-05 WT15-D6-B-06 WT15-D7-B-01 WT15-D7-B-02 WT15-D7-B-03 WT15-D7-B-04 WT15-D7-B-05 WT15-D7-B-06 AK15-D9-H-01 AK15-D9-H-02 AK15-D9-H-03 AK15-D9-H-04 AK15-D9-H-05 AK15-D9-H-06 WT15-D4-H-01 WT15-D4-H-02 WT15-D4-H-03 WT15-D4-H-04 WT15-D4-H-05 WT15-D4-H-06 WT15-D3-H-01 WT15-D3-H-02 WT15-D3-H-03 WT15-D3-H-04 WT15-D3-H-05 WT15-D3-H-06 WT15-D6-H-01 WT15-D6-H-02 WT15-D6-H-03 WT15-D6-H-04 WT15-D6-H-05 WT15-D6-H-06 WT15-D7-H-01 WT15-D7-H-02 WT15-D7-H-03 WT15-D7-H-04 WT15-D7-H-05 WT15-D7-H-06 AK15-D9-L-01 AK15-D9-L-02 AK15-D9-L-03 AK15-D9-L-04 AK15-D9-L-05 AK15-D9-L-06 WT15-D4-L-01 WT15-D4-L-02 WT15-D4-L-03 WT15-D4-L-04 WT15-D4-L-05 WT15-D4-L-06 WT15-D3-L-01 WT15-D3-L-02 WT15-D3-L-03 WT15-D3-L-04 WT15-D3-L-05 WT15-D3-L-06 WT15-D6-L-01 WT15-D6-L-02 WT15-D6-L-03 WT15-D6-L-04 WT15-D6-L-05 WT15-D6-L-06 WT15-D7-L-01 WT15-D7-L-02 WT15-D7-L-03 WT15-D7-L-04 WT15-D7-L-05 WT15-D7-L-06 AK15-D4-P-01 AK15-D4-P-02 AK15-D4-P-03 AK15-D4-P-04 AK15-D4-P-05 AK15-D4-P-06 AK15-D9-P-01 AK15-D9-P-02 AK15-D9-P-03 AK15-D9-P-04 AK15-D9-P-05 AK15-D9-P-06 WT15-D4-P-01 WT15-D4-P-02 WT15-D4-P-03 WT15-D4-P-04 WT15-D4-P-05 WT15-D4-P-06 WT15-D3-P-01 WT15-D3-P-02 WT15-D3-P-03 WT15-D3-P-04 WT15-D3-P-05 WT15-D3-P-06 WT15-D6-P-01 WT15-D6-P-02 WT15-D6-P-03 WT15-D6-P-04 WT15-D6-P-05 WT15-D6-P-06 WT15-D7-P-01 WT15-D7-P-02 WT15-D7-P-03 WT15-D7-P-04 WT15-D7-P-05 WT15-D7-P-06 AK15-D4-S-01 AK15-D4-S-02 AK15-D4-S-03 AK15-D4-S-04 AK15-D4-S-05 AK15-D4-S-06 AK15-D8-S-01 AK15-D8-S-02 AK15-D8-S-03 AK15-D8-S-04 AK15-D8-S-05 AK15-D8-S-06 AK15-D9-S-01 AK15-D9-S-02 AK15-D9-S-03 AK15-D9-S-04 AK15-D9-S-05 AK15-D9-S-06 WT15-D4-S-01 WT15-D4-S-02 WT15-D4-S-03 WT15-D4-S-04 WT15-D4-S-05 WT15-D4-S-06 WT15-D3-S-01 WT15-D3-S-02 WT15-D3-S-03 WT15-D3-S-04 WT15-D3-S-05 WT15-D3-S-06 WT15-D6-S-01 WT15-D6-S-02 WT15-D6-S-03 WT15-D6-S-04 WT15-D6-S-05 WT15-D6-S-06 WT15-D7-S-01 WT15-D7-S-02 WT15-D7-S-03 WT15-D7-S-04 WT15-D7-S-05 WT15-D7-S-06 AK15-D10-S-01 AK15-D10-S-02 AK15-D10-S-03 AK15-D10-S-04 AK15-D10-S-05 Factors Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours Genotype:Akita | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:0 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:30 minutes Genotype:Wild Type | U13C Glucose Labelling Timepoint:1 hour Genotype:Wild Type | U13C Glucose Labelling Timepoint:2 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:3 hours Genotype:Wild Type | U13C Glucose Labelling Timepoint:4 hours Genotype:Akita | U13C Glucose Labelling Timepoint:0 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:30 minutes Genotype:Akita | U13C Glucose Labelling Timepoint:1 hour Genotype:Akita | U13C Glucose Labelling Timepoint:2 hours Genotype:Akita | U13C Glucose Labelling Timepoint:3 hours 3-methyl-2-oxobutyrate 1057807.04 1331521.409 2493784.272 2268028.887 2326734.986 2537815.627 99963.3535 260110.0704 219863.2781 497664.608 377210.3857 267042.3114 227378.1175 200686.728 162308.1362 296849.5326 412402.0669 374539.3485 1061475.684 1461186.015 709762.2518 1698867.261 926444.7876 556706.95 1577458.591 896956.4359 979393.0419 2187303.873 813274.8454 2875310.519 244916.682 992791.6251 1457226.966 1599153.023 541521.7933 1883060.942 366249.1416 343972.406 1703394.913 362211.0026 397198.7683 394046.7191 409169.3232 610351.0989 400919.0807 893613.6119 453434.2748 415941.0602 2329062.448 834836.5457 1454602.828 2433281.237 3891171.093 2743853.202 436524.703 672934.1719 2152264.197 2801835.937 3298466.587 1826747.626 372263.1604 673244.7187 1246535.544 1186524.636 647479.8405 1886303.806 90269.82869 196814.9378 262714.4127 159533.3208 292553.488 327740.871 276758.8681 224364.1375 254664.0877 248070.4028 275210.8952 276660.3608 1593603.73 1617906.638 2029668.87 1473408.415 1733229.709 518282.9202 1178909.655 770689.3112 664412.2102 525642.7229 1506431.142 1774198.734 1965160.103 979580.4203 2948483.001 2709899.735 2034349.219 636098.4318 2771294.558 863956.3045 2437901.863 2629861.39 789538.0519 1896223.638 293929.8158 583284.164 575643.8143 677416.089 584409.3403 615262.2768 434585.8711 409060.343 463335.9381 437465.2625 564478.348 648936.6765 1150894.677 879830.5793 885485.9994 1612632.129 623091.3885 705106.6446 915759.4539 2050155.204 3538190.698 1263508.973 1338474.844 605740.677 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 226230.1835 480209.295 801941.2176 689413.597 530759.3155 4-aminobutyrate 19471901.15 17121734.22 29830143 16146086.92 23581055.92 26175356.59 78792712.59 79181555.52 75571911.12 78838144.09 71595715.22 71024275.53 74330796.44 63573521.36 56969621.29 55045284.43 52634357.01 51818917.49 25434217.84 34235848.44 29469572.92 24827622.1 30403128.59 29439391.54 39196170.11 35130587.18 35948300.34 33909499.61 34406685.39 37119813.88 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2017517.67 1333332.977 1256986.8 1313771.682 972167.5068 699266.3481 1621672.994 1544374.524 873918.1822 1068587.152 603860.1242 491162.1528 35629833.41 28913510.52 22200128.84 23621745.98 21704193.17 21296836.33 33176005.9 23470535.25 19941321.33 20421766.53 18752930.14 20248329.16 2220360.447 1171772.708 931477.2603 1259778.774 664291.2356 711758.7387 2562183.567 1354784.143 1463035.768 984451.9183 1299648.995 913894.0497 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 158208.3056 305085.1816 373413.8501 294493.8962 354449.4871 6-phosphogluconic acid 469200.3524 654680.0534 733443.6861 1024657.057 976969.4262 1259080.632 296032.0783 414570.5664 890126.5083 614949.463 647205.5336 710828.5718 355052.7291 423411.5405 486712.6309 536046.1695 551718.5542 549317.0743 435743.4362 499088.6798 685317.8687 882262.8651 1145904.997 958146.7327 590427.9251 646200.0849 796090.6734 2046879.266 2039983.942 1290382.744 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1182498.539 1071583.106 924220.2534 1055276.822 936086.7469 2068838.188 697513.5267 1130572.386 900541.858 870975.0934 744099.999 289348.4738 1090835.615 708256.68 673287.157 255000.2002 253554.6006 409391.6617 1469555.688 1316879.654 706570.6368 1021803.837 1066303.194 1203139.772 2279923.645 1055791.654 1839717.591 2135990.214 2353504.942 916467.0014 342353.6784 248453.6511 204639.0452 210801.5081 237042.1952 170055.2152 397016.6666 300043.5129 226467.6646 229009.1315 210576.8777 212619.8863 643497.9903 9179.209009 500476.6 369274.7845 45772.18072 365762.739 341076.9241 362705.7709 372659.1816 206856.2366 244964.2315 273649.9753 300978.3894 209007.2366 152704.5611 193276.8316 132159.0476 233178.7685 371066.125 259761.4202 241971.673 214816.2305 223098.3025 168758.7399 357122.5825 300531.37 444770.3858 313235.9752 584050.318 2885577.167 179685.9987 613952.5486 1621198.537 577354.9256 920109.7676 342012.256 315833.9982 545837.4414 373240.7166 502051.2554 839367.6499 152935.7022 124398.6798 158157.1751 262325.7727 253683.6337 108607.0966 54602.96227 94659.15441 334313.8916 358335.0035 155622.6971 261682.2426 46118.95294 801268.7987 242762.1114 118577.2703 153176.8819 202520.9635 98801.21323 246896.7675 239647.7113 300221.5736 127062.9503 184093.959 142970.5772 0 0 0 0 0 acetyl-CoA 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 453185.4677 408260.4566 281415.5275 197424.5311 461910.8818 324050.6679 0 71340.7797 112851.4796 114500.3054 101508.5816 75242.01845 42682.02008 136755.8724 223588.8329 45899.5038 175647.9952 280113.4751 0 0 0 0 28567.02796 174117.5764 681861.809 248624.9106 398225.2501 327280.3517 217297.8879 256195.0867 283696.8365 170138.7492 223245.8668 255864.7043 232259.4604 291526.1582 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 adenylosuccinic acid 171970.1497 41561.50985 43392.12861 35628.64457 52195.72797 49548.80739 101209.6673 41024.80005 41978.5028 253996.6268 184154.0101 37825.82555 155656.7318 40891.38461 18011.35875 15095.22575 41893.85614 29593.60083 478200.2026 159621.9227 279116.356 243931.2495 245363.3275 111680.2167 94119.01875 207932.7515 25511850.42 218162.4263 257750.6315 985107.5142 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 888174.804 484453.2014 855253.4303 472394.4371 292237.3283 2151622.003 1106783.432 140890.5036 367504.1439 1875483.476 975909.3867 188639.7398 3512454.163 417810.7854 253608.4116 515565.8287 505400.2179 410789.1145 2408562.861 2549880.996 2709745.152 2089583.542 2521462.698 627979.8624 1745659.6 790778.0568 1991973.553 2269780.687 1797600.595 2664365.541 142814.4519 103379.8248 56051.94213 73651.92234 228681.8992 401312.5375 1017531.068 857953.7986 746556.4842 694470.4786 821416.8343 440832.5263 165556.4695 65914.04889 142997.8803 220337.3283 118622.3947 102846.0386 294315.8754 119676.4338 148274.8991 24407.52712 77689.34614 19524.11967 111664.9989 104765.9111 203754.7395 118986.2407 84926.63329 51927.71503 67466.25438 152462.5991 165165.3015 115366.401 199076.5942 232805.1504 0 72127.84154 42493.583 240513.885 585836.9044 1037977.729 0 31062.3102 46886.61466 34933.42806 112642.4998 27864.67375 46177.90003 70503.73627 44535.61305 13664.66654 96205.0737 0 0 25465.05971 0 18379.93789 35207.18192 0 0 12915.58296 0 21592.81149 140846.1633 0 94808.55171 0 0 0 0 0 0 0 40564.75268 0 0 0 0 37127.23881 41905.07015 35563.01735 0 ADP 59211246.62 63114427.48 70224713.47 62028901.32 50808527.77 60158242.12 43826739.86 43256292.74 43837130.16 51754732.83 54921973.87 43918032.42 50438335.37 46952696.75 54431341.15 49148779.71 54936343.73 50400325.33 73571375.25 73030232.12 75611938.01 87038982.4 89357520.24 100553329.5 74488341.35 78457782.55 204912954.9 104364617.3 110332998.1 127287020.6 3514222.604 30319596.88 10627722.68 2068536.297 869200.4398 12683054.72 11723545.26 1145330.802 7672881.035 16107673.39 10797269.29 5300430.45 10333027.4 27294787.9 30275436.86 12001068.57 30932094.26 15464077.08 7913557.707 22925035.7 35557089.24 50013253.05 52771795.97 73426063.16 9824416.022 9958510.49 19552541.22 38388484.02 25225488.89 58558169.18 59387252.57 63661339.84 65663046.07 57685046.59 47667638.66 100452247.9 48098071.95 41482938.31 42528933.26 45932063.13 40158831.04 21456616.97 90877610.76 53864821.94 46112947.92 50457911.31 43716288.05 40529250.14 105910395 102181586.4 118276791.3 86066532.85 111187396 85537180.88 73808054.05 59844070.62 127802157 123504672.7 150880592.1 126649664.1 28039578.29 26949289.48 22707540.33 23197220.03 31345936.36 28369165.56 27267055.58 29717686.4 27539320.23 25804724.8 24632812.36 19402289.09 28812879.57 33475896.99 34558019.04 39530435.9 29092583.11 27987319.42 45765009.98 33184223.38 31792960.69 24000249.69 29317413.58 25921251.88 42519090.05 36484543.3 37707257.3 36628800.46 23311362.64 31533573.52 45942706.67 49524012.86 41180190.7 42358573.19 39383935.01 41542767.11 15813206.77 57048251.38 50546120.68 69486154.14 60022504.08 75502445.92 6834354.574 11546183.06 27403441.41 12041957.47 36874286.21 8537693.448 9034007.697 15401931.03 19870804.9 12106255.94 18246132.15 2218031.502 1573704.165 3638160.471 12070264.78 6047409.23 10585796.91 1750627.264 646510.3715 16580869.56 10046928.43 6151926.041 18816964.69 1501833.374 32783741.3 83732335.69 62617793.75 54404893.37 53814950.73 28459461.8 66936223.36 52396678.05 134358279.7 45086809.51 25986297 10704855.92 1538392.132 4540226.232 3829566.582 3072503.601 4865322.858 AICAR 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576135.1672 405539.658 389959.4363 191055.1377 56908.58904 794.7336481 521540.8405 402560.3504 261168.6424 343849.3313 115640.7356 22557.25528 402911.1209 270208.9472 428197.0446 270555.6462 195175.3483 182112.2543 25938.41894 40462.36565 38615.75414 48353.17377 71932.27535 62826.3561 450391.8477 122836.9165 93305.78454 213100.2017 171765.1267 420470.737 759314.1928 174752.2658 231302.1358 199223.0647 136865.3409 48192.46803 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 alpha-ketoglutarate 4298344.136 3231165.329 3364370.598 1630829.222 1282619.241 1401006.105 3507129.632 4179052.66 2549487.379 3386950.846 1338782.329 1335065.013 9187742.935 4755103.056 2883841.893 2882339.034 5099239.935 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22169975.7 carbamoyl-aspartate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7066.857006 38084.86832 33518.35681 30230.44451 34096.36992 32902.17683 34713.40178 20490.36708 19005.70139 24051.17514 37600.91963 32356.77359 702800.7673 742581.6056 306989.1819 630579.9283 390776.3201 411001.091 1604240.544 995936.5578 714913.9917 318278.8689 505367.7936 314018.4422 41208.95606 31737.78291 25308.25631 33163.43386 0 15998.35017 12366.44926 49397.30562 0 25349.97294 41133.35646 36172.22152 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CDP 1860169.543 1532740.083 1545609.11 1128681.286 1078609.793 1243069.08 5424243.021 6058801.411 6011559.067 3021321.936 3195915.61 2387720.198 11223707.73 9258492.407 9639215.872 9431752.704 2198996.96 2630657.907 4748411.118 3138554.328 3309057.489 3592033.794 3635822.451 2809539.228 2930532.26 3201916.797 14675019.3 3006077.94 2743124.705 4391066.507 58221.65907 328872.4494 155503.7293 38962.18575 23518.7773 161712.1751 184190.2806 52279.4816 134416.5764 225873.1959 158592.0056 75770.78433 152273.3398 407977.1649 450000.2919 163180.4832 345258.5397 140647.0525 158191.8009 400502.6065 305706.0113 559329.679 669073.5773 923936.983 137756.7013 120359.5455 363676.7237 554431.0476 258660.9205 814502.2384 2957630.173 2091738.743 2226682.084 1727963.914 1138235.563 2185524.705 2355223.151 1158076.484 1123511.23 1201245.244 751916.4921 441575.3768 2913504.341 1466895.301 1196345.714 1427965.696 947085.4221 682262.586 4001627.982 2674052.055 2429434.887 3215500.41 3363322.895 3092188.683 4812636.414 2841210.731 4483764.562 5026932.766 5367228.826 3149705.017 513638.266 507380.1559 405731.1845 360308.7994 445575.5751 203490.8203 1095448.199 1318183.686 1258120.445 957441.5345 778261.1021 510515.0494 650748.1739 754556.5453 805987.0785 1277607.929 414122.9849 478802.6364 1186504.612 748117.1298 708625.3933 401335.6601 658686.7881 473708.3941 1247476.865 1280646.014 1413858.79 2209505.974 1222663.137 1309499.363 1492865.018 2567148.055 2757657.763 2004458.178 1730456.208 1221702.108 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CDP-ethanolamine 17008510.4 20210329.9 21893671.49 19733343.2 20165513.26 22013504.48 10825327.21 13588472.38 14699078.65 13486314.19 14119698.36 12405609.29 12404301.06 14618651.03 15479798.22 13087909.74 14998858.94 13361797.17 20510556.13 23357622.39 26825138.74 23073184.41 23388458.25 22668430.42 19146534.85 24612535.07 31046993.45 29147054.14 29642133.46 36650946 4972829 7351200.921 5970807.58 4648040.109 5154355.248 5625592.242 7918127.163 7507116.54 8882784.599 6383682.006 8569333.628 8294824.044 9210814.903 9943360.123 9097741.6 8584823.061 9093521.003 8081204.246 10405206.26 13729960.67 11115370.53 7561401.431 13465081.76 10921792.97 7964039.262 10067301.12 10574845.79 9762836.114 10786283.84 14099053.72 17861938.28 23200623.06 21762778.85 22816587.88 21291729.6 25360415.14 12145129.34 16637328.68 16134035.02 15606403.58 14991471.88 14369418.71 14281300.92 17152616.17 18107269.79 17987304.93 16021275.8 16679864.71 24820263.84 25876517.29 29741624.33 22951929.57 24721594.33 22624223.87 22873760.96 28844941.13 35404052.42 32482736.67 39044492.75 35036459.47 102188.6889 0 0 0 158901.1416 185827.6557 0 91439.76744 0 67077.9834 66324.55434 129841.2782 4258994.315 6257717.858 4999589.063 4042347.927 6926311.117 7787863.413 4621800.859 4984706.183 4948018.861 3415164.169 4796174.415 5108845.172 0 133561.3271 106418.5323 33288.42087 49863.01801 0 0 132518.221 124276.6077 143852.4065 125466.8861 134020.7269 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 cholic acid 218552.3903 230786.4306 226625.599 201190.1661 114439.7867 112757.4707 0 0 0 0 0 0 0 0 0 0 0 0 43696.07245 44299.01273 58410.81322 43572.49743 65206.86225 81692.53784 132368.8099 110276.0358 185987.5201 92483.3609 108510.6297 104520.2183 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 800706.2901 464503.7603 257567.1947 175153.4016 141278.6194 117955.5468 0 0 0 0 0 0 0 0 0 0 0 0 174789.5737 64023.12732 37482.16685 34627.09271 43231.05559 31885.96206 843699.6504 175764.3068 86889.9531 73396.54306 70888.44535 117902.0841 13904830.84 11684519.06 11488841.43 12212000.5 9559073.552 8167172.197 11190852.04 9593732.557 6057219.952 7606185.164 7066134.416 5301706.734 665384.1911 1010096.907 575152.6404 448497.4807 359894.7771 200319.2495 168702.3229 238271.3791 490606.8478 148628.149 226948.5217 164827.7354 3013416.982 2368865.21 2232638.291 2330151.222 1916627.636 2710969.778 6786917.543 5302914.04 4721023.67 4306508.341 4545160.576 5014604.823 46950599.47 27149956.58 27660707.85 28886605.38 15322578.43 10496106.86 32677987.07 13810321.35 8075516.644 10801456.85 9513933.573 5641504.957 35277144.66 24372031.8 22948096.72 21616417.01 11766844.37 6147010.791 599094.2413 2707235.631 1645713.455 854035.7319 819374.1471 986781.9024 4668851.506 4023586.582 2836039.432 2781917.382 2344767.628 1978680.927 13400051.75 7423171.703 7175744.618 6634818.855 12202207.44 9823961.276 20468414.4 11006674.1 9086065.671 6962615.709 5960045.031 10846933.72 28245859.35 14140545.76 31439134.18 4488396.24 5004127.379 cis-aconitate 3790918.408 4737685.973 4762775.303 4429431.772 4283740.917 3887720.581 3998153.357 6023401.085 5299809.024 3743603.34 3642144.289 3925229.78 5572447.109 4882999.924 4125896.737 4014736.108 3939710.721 3919160.539 4192761.45 5949725.654 4968269.084 4063069.705 3745057.187 4228042.629 5008499.121 6151247.863 4839268.282 5468482.107 5739167.637 7079431.776 998423.8701 1508617.867 1497910.352 1639990.65 1843726.902 1450307.447 2282883.884 3045010.343 3332669.126 3145610.075 3403873.67 3670930.291 2563033.748 3303558.946 3297329.328 3813324.186 3756360.457 3221833.44 2510888.91 1227165.438 3483267.932 2704723.767 3179385.234 3687987.324 2506002.046 2761440.575 2271451.446 3096362.94 3312922.683 3733813.388 3407412.48 3356962.15 2949401.302 2882935.999 2417212.583 2999752.697 5384116.109 6254808.71 4845831.475 4591315.973 3177181.792 3203921.659 6915512.754 4919835.7 4390523.828 4539945.672 3565767.651 3502675.843 4872177.762 3515693.993 2401725.001 3581836.62 3182245.453 4189970.993 6148343.446 5562998.769 4762270.348 4255963.987 5428178.002 3232674.41 1510505.034 2899246.191 2429840.321 2199860.402 2671791.256 1645407.921 2199977.108 2043723.868 2265628.245 1832152.173 1707434.931 1340339.742 3904966.609 5354284.918 4702598.284 4355926.055 3641532.756 4508050.048 4204248.93 4429936.098 4294389.975 3240623.388 3770440.891 4148646.89 1739553.479 1417145.507 1699480.446 2446644.105 1118331.234 2396800.01 3736813.177 3295254.204 3590001.129 2746090.736 3250597.23 2911106.074 4785741.257 4982081.55 4644943.347 4684731.758 6541025.949 8190370.783 4420089.807 4956217.498 3150742.782 3992325.899 3596905.057 5034495.324 3494405.605 4305965.438 3502580.876 3360311.746 4333748.991 5161519.936 3161977.576 6242885.583 3937783.395 3879250.361 3251689.693 3512659.552 4465282.496 5448700.26 5760170.195 4443692.632 6094513.622 4573000.896 5750670.517 4158480.208 4949300.551 4159527.179 4981307.738 5130264.715 4453122.961 4405991.67 4108168.867 3459128.17 5314603.346 5459820.828 3891178.578 5442265.632 8301633.835 7336323.321 6759604.171 citrate / isocitrate 105770812.7 128440739.2 116062504 115788759.2 105657570.2 100951616.4 126358382.9 138484229.7 134791367 117949086.7 101399355.2 101370805.2 126763326.5 121757675.5 112422388.9 109116062.9 101954840.8 97472713.84 118981380.6 155681414.8 141108413.5 123477207.4 119913761.7 134101690.7 138604973.7 153271654.7 159109915.7 166048232 172513691.7 198297902.2 355033.121 3974944.411 1165618.137 362017.243 467625.5699 998564.5986 2604151.463 1400179.798 1612316.42 4269420.094 2327551.49 1416671.443 2777970.282 6499250.435 8896049.213 2685107.544 11626785.5 3578285.536 517351.6111 961200.6303 3407528.997 8280312.517 5403306.976 22759010.9 893725.9589 901151.0635 1643124.916 5516585.36 6017246.417 17305982.15 95250316.09 87197929.64 78773223.52 72947110.8 57608149.66 93322555.92 146909409.9 148486089.8 121204171.6 120713805.9 81575838.77 81150151.91 149350349.5 104672068.3 102434852.6 108424384.5 78838938.18 71950611.84 114827636.9 88910713.23 63280193.37 100463311.8 97433539.47 125697449.9 152219498.1 131063580.8 123184969.8 130414854.1 159018511.7 99539319.9 50463684.01 98324769.25 78010794.31 74919528.65 90556105.97 60480117.47 78319601.85 77473521.37 83108602.8 69464961.02 65601527.67 47133175.1 139452003.5 164002089.8 151335654.2 150766061.3 123664283.7 145276448.9 137645564.7 132037945.4 125304595.8 109249959.1 120510878.9 117382237.4 63811386.83 55290126.47 66323214.09 89956553.35 42730843.4 91215204 116988573.2 108749734.8 128781718.2 98976513.23 121323401.2 107008047.8 127502960 161280795.7 166123725.9 156844754.9 168383985.3 217786111.1 145565497.6 142554658.7 107877242.2 134192312.6 134859576.1 179551040.4 108883019.6 110750092.3 113779698.2 126245566.2 125854058.5 175822805.5 71033432.85 163035726.9 144803342.2 133055616.8 127109400.8 141511617.8 92669884.43 159814838.1 165356334.3 147615309.5 166002926.9 173273941.7 126380125.7 98462168.47 72447405.21 103752095 99272293.48 137907683 122854896.4 127667045.8 121678290.2 105852197.1 137465697.8 159995509 132473398.4 184416122.3 211503579.7 221307383.3 253958058.2 CMP 696037.3752 533063.0053 520707.7618 382810.8715 354022.0997 416717.8431 612560.2033 521016.4264 504957.5674 637091.7934 599041.8971 483791.0293 969643.4169 749297.4827 966219.615 725033.5484 584334.1172 519269.1052 2371631.803 833241.4939 956833.6224 756010.4319 906569.5529 637071.2067 607137.0073 1030960.993 21684376.77 704758.2172 743032.2791 2111157.698 765058.1766 839362.2278 940154.877 596081.4142 720377.7461 815434.3314 1547115.845 1040576.411 1504737.581 803336.471 711471.914 940110.3086 1579406.99 1277248.916 1270465.711 1389306.592 865672.3996 715418.1454 1582247.001 17855472.79 1009906.805 821232.1871 1659155.599 1348299.417 1335802.571 1255234.968 1759889.539 1364816.904 1318881.071 1332248.907 5261127.92 3184249.089 3800209.837 2717238.606 2160936.188 3322271.873 2284317.161 963443.8133 1207366.296 1728139.055 1327239.996 950898.0075 3255641.375 1370171.907 1271770.211 1283230.079 1386600.215 1192539.527 3657126.587 2472505.937 3116068.19 2376257.189 2495480.73 1992327.347 3632843.574 2442837.115 2936701.892 3325790.39 3004934.838 3542912.862 1596746.758 1465631.689 1160204.677 1098951.813 1375990.361 872923.1012 13501203.6 9562630.877 9084783.362 7809145.784 7360962.377 5193384.581 1763042.331 871742.9209 1259894.902 1656448.064 1012393.848 1119470.18 1057904.155 1164636.937 1141718.248 773622.2529 1214094.934 765596.4199 1526552.882 1741968.951 2133642.284 2904521.591 1606529.272 2312900.668 2514132.613 3542440.572 4833278.523 2854040.963 3402287.998 2740400.594 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CoA 314992.8156 200962.0388 137073.003 196627.2378 412691.0854 654973.6759 302887.3409 532379.3475 511019.4091 260709.9783 637388.1378 497000.0699 45150.64889 207007.9036 87743.46386 29135.74746 886476.4171 779982.3718 1051516.164 920520.2775 920192.487 888338.0662 854222.9969 868704.808 1295866.996 1070622.909 921835.4595 1103853.092 1122284.128 1064367.46 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 66931.64243 102166.0087 96205.3336 37814.65857 227831.7197 431867.4677 230268.7113 704190.5061 527077.109 846923.9774 640031.4312 314067.4489 241315.49 127598.6822 551144.9514 373124.4125 1211142.244 785242.99 1299171.863 901338.4987 952961.8646 1080646.29 1067130.119 898489.8773 903081.3535 479802.0551 975817.3373 1190970.245 920829.8403 1080639.418 70666.81881 65149.12159 54055.37819 51671.29728 206492.7263 119432.2793 108340.689 38455.4392 0 0 0 0 0 45318.99212 0 121368.281 0 0 0 0 0 0 0 0 151079.8792 34991.29279 95890.64635 87718.6757 37896.83925 0 61004.30059 38152.1031 106333.7191 24151.28601 48758.4621 52928.27128 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CTP 12323074.98 10915253.77 11233288.81 7881792.073 5533030.784 5259158.699 3735778.639 2645999.915 2709655.583 2986552.566 1129245.828 1005122.687 2712716.706 2738615.68 2224797.952 2162616.106 1681699.25 1285773.654 13860002.34 12724346.2 12260339.77 15113178.87 14629716.96 17483589.14 20156796.43 14037592.07 9204790.692 19979838.81 18185388.83 12033211.3 310680.0437 1756664.691 715938.6583 115451.7789 35353.25678 509316.6877 607452.9149 39724.56549 231636.1639 1062217.918 440930.8892 182106.6826 355657.2567 1402227.976 1540774.239 297025.6163 1241199.247 414356.4648 616847.4789 108575.7622 1702192.984 3167599.955 2695150.828 4673751.541 815774.2049 659650.3098 1108757.302 2038355.197 1222596.885 2497301.928 4039381.818 2917084.896 3001658.177 2092370.038 1374350.92 2157424.566 2798333.638 1912403.609 1113657.421 1212353.448 346799.8389 256568.3782 999537.4561 1073557.863 857489.6557 1257438.681 432958.9429 238938.0221 4766071.547 2352730.833 1819086.477 6149455.909 4404502.733 5342089.428 8443329.138 4656514.561 7707782.684 7771626.219 8008198.518 2263185.776 861168.3436 1452517.155 908514.0018 688301.9302 704211.8945 135667.9354 442380.7937 446258.0046 498341.3402 294056.0188 205571.8682 122290.9062 1108327.091 2351254.952 2624041.131 2276484.349 1093463.083 1532050.282 754402.8238 1481223.687 1682067.311 801356.4947 949884.0706 668654.1512 2227186.574 721832.5229 761212.7718 1250321.061 790553.355 987064.9522 2866179.079 1324821.781 1087474.597 982137.2736 798119.0023 1002809.586 73623.37701 33648.15913 52850.29385 282982.8001 128734.4402 105802.1111 67221.32234 95701.62565 146100.5674 103133.1369 239930.3492 45965.42883 122958.9962 68797.68549 110185.9148 95862.3816 56828.11909 0 0 0 0 0 32090.68363 0 0 0 0 20775.02012 0 0 17464.43011 80758.81964 67696.71531 65415.49817 47304.57633 146691.548 78225.48664 85007.7528 106360.0895 92539.18492 50978.57647 63534.05541 0 0 0 0 0 cysteine 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 40361.43985 36220.15735 42580.22724 38794.34424 72086.42785 76882.79686 42445.77108 21535.06629 29230.07432 34267.16549 50825.23643 68936.2688 0 0 0 0 0 11368.45263 0 0 0 0 0 16637.87768 51953.91994 89719.1693 64882.28301 63703.50227 45700.2088 77904.41285 36423.27801 17213.47044 51153.55915 44953.14432 55229.11802 57696.89084 47408.24041 0 0 0 16238.45642 11402.14189 45539.50735 106991.6196 0 32281.27643 0 58132.04935 80605.22758 23967.89783 2494.048958 91415.77677 24266.43836 34038.73402 108258.2156 1132569.209 770144.2119 709142.5101 151185.6616 1124767.239 0 622956.5171 650195.8157 248388.8772 360663.738 1262961.128 0 0 34874.73935 91027.416 64332.27424 207798.0825 54080.08445 88000.78795 0 72910.60231 254204.3847 210740.2744 0 332080.1021 1144268.891 1066525.092 1476088.939 cystine 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 108024.6279 78871.96843 77580.9289 100511.3523 67324.50588 64509.29874 22883.2832 50623.81398 67763.58953 67695.70055 62378.33822 58291.6054 0 0 0 0 6010.20884 26160.58763 46131.90788 56215.83077 39427.49124 35863.52865 30714.31969 19491.45313 42708.81034 53760.38568 51425.85961 45874.28812 69080.4368 23393.43111 38549.14379 43385.39992 35950.64334 46663.57573 42009.36464 35311.22856 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1335009.753 1198747.762 3533926.36 475490.9652 4651888.894 cytidine 415116.2323 587549.9304 873425.9429 979173.5554 1171666.866 1119840.161 235917.9381 804260.7383 787541.1495 890125.3733 1290499.506 1056869.38 1027073.91 500776.5751 679386.6718 921256.1501 1060043.785 1100809.68 1152370.572 2039819.435 2577090.732 1279999.701 1495334.481 1259564.548 335704.4513 978091.0676 1266936.652 1325823.652 1635531.147 1657837.735 298225.1471 282202.6936 319285.9947 303712.7503 374593.2832 376274.7493 315497.276 332549.0342 348341.8211 360043.5843 495683.138 289681.8772 1019616.1 283764.5054 254776.8519 331225.3277 449782.736 424566.7367 934953.3926 2150996.987 1267235.8 389675.0932 658872.0863 462745.3784 425649.8505 390951.0164 432566.1181 412700.6873 661923.2048 1028602.833 2018236.126 499249.1451 679237.437 680194.1703 669010.9533 808526.2725 1209676.707 257545.9425 387854.4702 1773250.076 1223139.623 442641.2711 2312870.872 440074.8231 572287.9701 623436.024 603179.4101 856902.849 4845715.537 1814246.34 2840093.714 1229343.898 1385131.798 403171.1752 2289470.526 744600.02 763765.7463 912656.5454 633223.0245 1347735.89 1245980.178 620513.7414 525546.8905 494021.2643 543666.1857 527319.3516 1211525.965 690998.0932 1090175.667 530322.4928 505353.8697 428023.4332 1539020.429 649644.739 813618.9457 1036441.749 725331.0249 838288.8741 1668218.988 802394.6569 1076691.871 929557.2707 794611.0335 1014719.369 1135635.868 948937.4436 882268.648 774817.7076 478267.4136 692621.3449 809289.1084 907516.8395 1132527.775 649517.2897 921213.7638 710325.8466 360082.1495 0 0 0 0 83135.49266 361474.6236 241545.6635 72046.52152 247127.4875 123677.3844 268544.4877 354998.1932 79073.61321 191072.8441 365671.7209 182574.0575 180621.4776 188312.8999 154030.1619 216859.2318 434211.1182 427391.2619 424253.8804 293888.4016 189270.7744 222250.0902 368499.8058 462449.2506 402281.8673 284965.1319 0 229167.4432 188003.7408 0 369516.0204 72358.98467 104624.3025 0 162383.4359 132958.0176 179897.1181 155370.4519 109818.5897 127739.4866 113917.4141 101308.0986 deoxycholic acid 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3471319.347 2043887.915 1375491.413 1622343.831 915070.8585 563451.4106 1883402.884 1217892.695 520139.3985 462123.2884 340811.9469 275727.6905 126224.8875 84374.60876 68527.27677 49559.81952 32460.07815 0 104648.682 87702.00922 70419.35505 58282.91147 137003.2925 32500.13295 364273.0403 264800.3304 70619.93957 193917.3499 0 195026.2554 1120713.839 510991.7819 703182.4065 254156.9834 446034.6857 256271.7642 7752152.384 2641695.284 2616890.815 2345858.067 894363.3585 761709.4143 5143908.886 1124001.455 670260.0935 403216.1334 665873.5294 0 4837829.371 1597813.492 1469894.411 420202.7797 0 0 863885.4608 206910.2263 215972.1005 125820.3632 0 0 905152.7115 473669.9555 422369.1747 232307.3581 193451.331 154130.1504 1393824.069 590681.1095 286568.0317 478014.2482 252449.1328 0 2144582.937 863282.7164 810300.9053 212928.6555 276688.0549 520336.3274 4485518.682 1994533.371 1799330.094 455198.5523 214866.4609 deoxyinosine 53695.96786 35207.11903 35805.45641 33085.82429 32784.09247 52574.55897 52030.03797 62449.31847 48412.37012 48338.43756 51375.17236 41661.64682 65105.65662 59414.51243 56724.61959 58319.90014 66366.7326 45780.68255 66066.40952 76447.90583 84912.81514 35290.72168 33883.8227 47911.74163 65712.37181 38978.18189 37938.87954 40604.29939 43846.52047 152440.9698 103008.7244 70618.16765 63720.73948 79634.5696 82201.71229 74197.57123 109562.5446 89715.02217 90676.39649 49247.15945 85466.8689 86630.5449 183427.6163 65820.15938 87000.64686 71866.60066 73917.66977 71438.8725 175202.6492 453387.7207 205220.1239 87733.28465 133271.1432 153042.7128 97054.4381 101908.9808 131727.4751 124115.2111 136377.0399 243549.3034 1767842.009 1163186.868 1128611.813 731608.9775 328939.2269 264556.3164 1203843.316 615205.9492 726307.439 482753.0149 256817.4065 146104.8028 1140185.113 703866.8873 727465.1896 617893.8193 280980.9815 215484.5906 1687615.944 1227569.301 930647.2499 558129.9651 430325.0898 405335.8309 1870349.485 1001795.054 1169338.845 545682.5798 304801.8741 390324.8401 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 dihydroorotate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 366927.3385 813058.2067 349753.1222 533656.0679 206700.7296 198101.5352 1038415.745 696720.3964 556484.374 97484.87747 312332.2801 74488.30323 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16235.59347 0 0 0 0 0 11228.97613 0 0 0 0 0 119324.2067 161762.0994 131701.0003 60370.7265 93727.53208 69323.23878 155219.4842 93824.23859 215772.0076 128030.4029 96282.17608 125477.4785 16648.73252 0 0 0 0 0 19725.62464 0 0 0 0 0 52516.66267 60540.08002 0 0 41776.18804 dihydroxyacetone-phosphate 1938737.446 4049917.255 5230431.29 5356178.229 4127509.99 4410636.466 639394.4241 587657.7444 1683006.807 3729173.947 2457918.983 2071986.246 1134556.432 1255107.299 1515882.62 1829054.15 2966264.84 2697251.153 2135909.946 2293937.937 4097848.823 2884361.34 3905148.197 5124234.365 3196290.865 7233613.087 13527630.69 16367483.93 16885610.42 11713371.29 235187.1318 1045841.647 631156.2946 338435.0281 276732.6895 653689.1161 683297.3755 388633.6463 896374.2702 2336458.1 1513237.927 1198432.625 1558160.855 2019423.207 2277013.21 2368643.589 3480695.012 2468583.259 529937.1023 751256.4431 795969.1679 766822.0408 1527871.345 1200613.284 526365.0205 632735.2313 665833.7723 1398905.11 1206231.223 2311929.661 163551.8469 788892.6068 711684.0295 829319.2984 671837.6634 931868.4383 423107.9005 179234.7297 263162.0889 1793294.29 819578.306 443699.3801 244351.2245 239170.9619 309322.498 436601.7085 696285.0201 624830.7013 594224.1207 698622.5687 550634.5437 720307.063 678279.05 878451.4106 708048.9102 951423.394 1735859.936 1335409.099 1664600.521 1065571.87 899201.9514 361736.4294 362796.2192 479684.3247 567513.7381 915128.5418 845229.2694 717699.9001 561857.6294 426214.8219 411941.2073 222610.7885 2954847.031 2480464.02 2299103.771 2245859.19 3686009.773 4979768.364 1179393.575 1260404.489 1765063.674 1570078.479 1502828.222 3973440.713 211769.7247 291629.0713 379929.6457 365957.6594 196997.6195 208193.6936 640691.2452 1031522.846 1138674.958 619554.7617 680285.7739 570425.3247 194168.6785 85914.20732 38774.04031 338264.1829 190570.2858 208027.796 57631.79782 87851.35803 24506.59714 110875.6464 178270.9453 55407.99166 78525.53064 13893.45712 126857.8065 53930.06003 0 59560.3724 0 409376.8542 1919535.155 1092492.714 225416.3021 206222.0441 58954.22146 1172281.301 1723061.339 334339.7612 1225684.917 286806.129 136683.9802 126870.1416 76139.05929 89169.71455 120812.1121 79526.57758 88916.54354 116014.1041 276456.2578 291385.3746 107578.809 49767.5067 9796.226882 204356.1132 275027.5447 162387.1682 514406.6117 dTMP 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2860162.802 2271575.748 2990518.957 1888092.058 929858.1282 1158336.907 4969960.997 2580517.738 3415838.669 3101948.752 3173146.487 811236.2652 7090282.957 3360170.349 3306542.888 1563846.97 1324270.252 1312350.717 6643886.364 5693474.929 5942823.933 1101743.796 1244576.459 545232.2605 3057036.525 2026697.958 2989759.594 1100896.38 1303070.716 2017131.225 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 dTTP 0 0 0 0 0 16719.77925 186727.1004 245486.7661 221218.4221 194309.157 142342.702 98070.59341 214294.9991 208541.5 208264.5664 209738.2253 151172.4705 100834.6819 0 24796.02652 14342.63516 0 0 0 0 0 0 0 0 20140.69444 182700.1655 1024511.395 429911.5878 87803.79554 25635.2509 340879.7089 454815.2048 52674.26761 291361.5267 703469.1669 440363.9653 149927.7202 439528.2604 1599435.516 1711961.968 395653.9362 997211.9005 384107.3743 428376.0993 170389.7639 1200020.42 1217181.782 1196798.209 1485997.5 499884.4499 498076.7254 817330.3981 1090687.735 742956.662 1324776.834 2963005.261 3626300.499 3117042.729 2341324.35 1059686.077 1528129.996 3025747.492 3704240.653 1659055.606 1303107.959 653962.1502 338749.1787 1676058.269 2886581.044 2826778.846 1694962.172 672901.1901 323121.4236 3492886.016 3167551.734 2087167.057 2750697.688 1968025.356 2178573.284 4755506.177 4674186.013 5921412.651 3762350.853 3340683.087 1437479.307 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 erythrose-4-phosphate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 772112.7902 1313174.357 1436292.924 1174979.544 1090957.01 1257580.384 768728.5588 1413898.898 1157504.925 1191016.568 1323841.476 1458659.324 754047.5026 1591386.199 1429880.823 1307394.974 1327376.526 1456193.487 1912165.797 1586712.097 2506314.105 1612890.471 1993222.059 2251204.454 1712012.625 2190919.392 1638010.884 2221069.011 2467597.273 2833950.53 2211842.42 3159662.68 2657118.495 3088051.81 2946221.799 3460361.336 679056.3598 1333916.742 1025436.371 463009.9238 694572.9269 702279.5801 696418.4206 1016501.976 1060922.314 686966.029 812075.016 637446.0711 2037131.708 2571598.002 1525121.784 2331944.428 1736178.34 2586542.375 3962691.054 3667511.538 3522381.241 3832377.214 3564168.765 1858488.982 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 fructose 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 967856.6371 717894.215 792487.4724 850893.5777 1514207.256 1317798.5 1853214.046 1138012.628 1649286.502 1991689.314 1677422.541 1995154.401 2629092.076 2320066.898 2717048.674 3249480.73 2720098.327 2757244.842 2700662.681 1989824.181 1413962.967 1947132.908 3165640 2245084.696 3211489 1002428.197 1026654.048 1202236.891 1313560.766 1217654.187 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 977348.9035 977993.305 1005569.517 1281896.365 1862279.199 2467614.222 759383.9732 878156.2225 989370.0656 1079665.068 1681821.151 1949046.485 839799.8885 9655731.344 770291.8295 1455076.923 821980.6348 1004570.324 763566.8655 795491.729 866885.8459 577528.016 752570.695 853274.6996 1827019.278 1574734.268 1856435.095 1493927.243 1120747.166 2013987.778 2109974.845 1250508.163 1420388.978 1361734.599 1354406.808 1442984.036 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 fructose-1;6-bisphosphate 19012499.71 9677414.986 9375407.292 6119734.217 3839861.549 3720950.439 9080357.416 4445678.913 3777598.654 15657615.72 6849470.654 2435400.067 6319215.356 3670556.893 3570074.687 2132777.085 1846375.282 1572150.641 14443232.79 12100042.35 11527229.49 13539654.06 12460089.63 6300368.783 23603736.14 13331500.81 141702759.5 11880017.54 8982479.996 7579878.839 109876.6383 1378113.873 198577.2512 53189.95114 39520.69857 267264.7959 227554.5555 29177.12632 27626.82686 203456.7709 43411.19366 20584.06321 65752.70966 87044.68192 228265.3467 36000.66634 140181.5121 55058.5017 67074.28004 2299543.133 155651.8487 325053.0694 492127.9642 1174702.058 63035.42823 71081.01138 108249.9548 274444.1754 57847.55655 310615.1464 5901016.564 2334851.991 4109246.822 2186136.034 1058647.536 5613155.374 4909004.444 1822310.302 1597459.049 2711462.054 1194259.752 453386.4232 1737400.849 1127895.532 960453.3588 1500096.389 913455.6874 658458.6848 3823777.853 2540868.414 1678877.638 5362503.752 4763090.22 4255715.286 8718884.747 4517382.779 9168023.143 8225640.507 4075984.562 2342161.75 9534192.082 6553563.264 4862998.675 5138640.744 6863251.836 10051898.92 10445672.72 9350001.581 7092628.597 7639269.612 6121424.965 5896773.418 8663993.826 6169919.954 5876136.346 7479813.133 4877975.558 6142823.357 2667778.962 2365008.933 3859414.336 2510436.313 2296216.144 3173785.957 4027438.263 2301862.929 1712519.429 3207938.515 2614061.763 7146915.323 9351945.073 7021114.022 3762690.559 5097631.618 4108171.116 3019979.588 8004684.561 11656203.49 13180493.46 18690915.81 24129073.82 11080931.54 2155027.573 2247231.894 5542236.027 4016227.896 5816208.71 1666409.454 3994937.134 4289787.31 7773075.369 4850100.73 4982962.889 315445.2778 1108445.388 1195867.371 6002698.002 1763549.777 6806128.327 745078.8757 2657864.08 7544602.855 8111592.501 2968191.442 4391614.682 3173674.707 41918426.66 16322733.05 9742055.202 9799052.167 8192756.755 10915546.05 19018908.99 14221885.15 14080323.92 11355025.02 9077902.908 5308352.586 187114.7602 271506.1848 299806.9675 297419.5976 892752.1228 fructose-1-phosphate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 11042136.9 8727644.058 8297103.309 9452989.492 11171502.82 16396358.39 12626066.83 10458704.7 8506953.288 9901837.241 9200554.948 9587436.537 1340214.387 1265653.565 1439269.453 1030320.036 1099770.699 692856.5728 366245.707 410054.3516 542489.2805 512474.0703 310467.2771 437695.9871 8384775.933 5675870.82 5276201.114 5944503.869 4547186.572 9630579.384 13858090.74 11801720.35 9808205.99 9636512.794 8762873.79 6891745.847 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 fructose-6-phosphate 12725914.44 22406847.08 29898227.93 42336109.72 51017758 62442115.4 1673656.782 1803596.636 3103378.878 2543091.347 2934151.462 3059230.234 898685.782 1119120.495 1285262.78 1010723.01 870692.7631 901605.1372 13567762.17 18690499.3 26721595.27 26445090.08 36328772.99 46510617.22 12124564.28 26717682.65 25511349.96 66008680.07 73795584.23 94827668.38 7883585.788 16089202.43 13783884.49 12313617.5 10393382.83 14314221.93 5053477.726 6809508.866 6212752.799 5754248.688 6924830.505 5812688.459 4357345.089 7956124.675 7545308.516 5220631.902 5042181.5 5266109.496 14281160.49 16651339.14 16229880.75 12052110.63 19673139.22 21694077.33 16427261.78 23754190.72 17952761.78 22203178.76 24816989.45 25434769.39 63778303.24 82864582.02 71670713.9 76641473.88 73751340.24 88762924.05 29141199.62 29877400.54 28453109.21 26277396.61 22404643.92 19335212.63 20145962.17 23004293.12 17820786.8 14490841.61 20115325.82 18898311.94 59631065.36 67669780.16 42527765.2 62298746.42 48074607.77 64140840.1 91861337.16 93678057.29 81644277.68 90052309.27 87972006.65 48788620.29 15602816.25 17162466.6 17133953.07 18140018.87 15389767.03 12754002.3 14348395.41 12331846.77 11507237.39 10493904.35 11406346.34 10758756.49 12837694.27 12770628.89 13006541.79 11609229.94 11395067.05 14219248.44 8314282.069 7835614.363 9720968.938 7225482.452 7805359.242 9200183.875 12158744.2 10131688.82 8538056.029 11890818.48 8268733.358 16904705.62 17688741.8 17308429.81 15503722.39 15681127.82 15414599.49 14200971.26 681210.2413 2471232.197 2790105.157 4198778.198 2325594.047 6467053.685 278137.3294 532035.3932 2488806.011 1112980.63 1990722.97 267141.1698 82932.88576 679866.3733 1191305.36 788215.4013 1825495.896 375244.5059 0 86914.33724 262214.5517 189897.6818 359317.3318 140426.2019 0 576794.6952 317526.6985 73299.00723 346914.5175 113355.558 1823086.75 2331468.227 1903937.126 1723007.092 1709290.858 950235.8668 2061642.116 1893999.099 2079869.754 2653394.932 1321440.327 389316.0219 0 301667.1579 196827.169 321652.8793 620621.2774 fumarate 44627726.51 38762922.16 36809527.41 34736563.3 31619032.06 27013642.8 40488421.78 38458479.31 36894196.44 36492468.35 30507992.34 27896924.84 48802104 40109399.02 36207917.07 33312895.46 32675862.58 30870005.19 52000869.54 45996964.75 43105048.49 43401502.71 42743432.13 41341774.68 61720836.33 53197144.15 46062921.53 49383650.83 41014212.16 37070520.65 6706627.693 25025359.81 16414538.5 10926789.35 3548919.428 19233037.78 13107422.98 4570400.804 14151409.33 24774594.26 18580196.09 14899690.76 16294979.2 26662988.85 33650447.37 27090979.6 37412534.29 33501143.82 10781334.12 18324871.44 24658702.34 29132261.77 31676921.94 28684367.85 9589373.381 17290467.23 24876343.17 30079297.5 24693814.52 33088248.68 43736044.32 41656048.98 43984724.05 36022604.68 30675177.26 46189881.09 47171000.29 34276021.5 39914262.44 49604468.46 28484978.95 20736014.16 53823552.75 40532591.11 40919801.11 48969131.06 45269805.89 33228189.25 60941797.26 41069592.45 31011765.34 54291735.15 48536746.71 45142055.57 73708356.79 49710580.87 54782927.01 56231210.58 40109328.86 27625404.32 25641413.82 28873019.43 27591800.04 27270803.54 26147655.73 22579215.44 22441440.39 22131687.19 18391427.86 21480223.16 21485746.23 19755188.6 26877859.31 31997399.13 26265379.73 26798642.28 24137288.43 29714529.15 33939395.59 29766691.85 29964735.36 24451954.35 29423258.17 29602942.25 27780941.27 24066933.12 23217950.66 27117096.1 22661823.15 27323784.72 32428634.86 31990994.3 32140811.68 26092199.12 28001920.46 28279588.95 14585299.65 31389674.71 29705455.31 27261860.58 34255783.79 38233201.89 10181064.94 18403035.69 16101615.52 20650280.62 20801280.31 20415312.36 12320219 20275324.95 19762321.73 18716699.26 24161908.3 24379606.93 3251389.947 9725805.338 10243099.45 9933032.373 8744433.987 8372335.9 5091948.623 17126325.62 13996121.46 11045474.79 18239548.17 16103810.58 15596389.32 24187941.87 22333420.8 19309907.91 17457099.46 18923779.81 15573620.35 21716694.33 21757016.85 16438039.7 19236867.33 17648051.13 0 0 0 0 0 GAR 2914798.286 3196737.859 2989735.428 2923737.754 2853299.374 3112589.285 1651680.515 1508507.833 1730613.718 2458888.689 2337206.907 2082071.322 1767107.027 2030273.424 2048481.48 1661684.817 2598063.97 2873574.296 2619945.893 2491219.933 2893519.216 2478290.723 2820490.041 2964016.421 3362773.708 3378866.683 3455587.896 3274108.097 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1518318.689 854668.1846 1040759.735 166903.8492 241821.4996 273269.4208 861057.097 456954.6377 1056002.436 153263.9367 128744.14 1046804.136 777864.631 701010.2112 1133456.647 56584.69616 2328932.475 3482924.185 2417697.627 2662214.411 2476708.355 1580253.899 2933573.831 3064210.471 5765278.057 2129778.777 1340311.155 778566.2344 135291.6162 274286.5198 269067.5707 202061.0816 335786.8069 glucose 784807.2489 1495813.801 2124675.673 3510107.165 4648491.983 5305256.641 266843.5029 956117.3955 1443652.171 1817635.957 1541364.189 1537327.783 424140.3648 565060.7554 1317919.237 707046.2392 1548302.899 1610242.622 598790.7535 668564.4547 774406.3709 2070661.121 2766859.769 2526193.424 460586.0828 1319682.084 1199332.441 2339692.666 2354663.356 1334437.568 236557.9271 2004935.666 2449852.264 3603852.417 3954585.73 3455955.544 2651207.934 1143877.844 2055437.04 1839501.425 1612345.982 1742476.867 2586730.207 1181138.454 1274458.425 3339715.094 964423.7489 3260548.127 353223.263 148131.843 238383.5357 1223032.663 2140095.557 2384878.287 248490.7839 1437088.299 1184107.725 2178838.969 1714549.021 725360.4151 1988702.447 4495031.4 6194953.485 9200842.995 8759994.63 9051623.583 1495711.38 2008682.816 3462483.476 2745807.662 1010161.15 1914238.929 831335.7233 2643574.899 2835435.586 2554866.925 2806168.15 2108903.588 710962.1754 962174.7161 380721.1564 2593168.16 3439648.648 3508412.387 1199043.052 2818097.303 2678660.755 3772479.842 2942566.058 618839.8889 948652.758 4695428.405 3311743.439 4373109.612 8111677.124 7558559.906 1233244.658 4192493.056 8371605.722 10483168.67 11328633.81 9976901.252 1424705.276 2198969.52 4270147.37 2084062.864 1946389.078 2633478.206 620655.6782 1571627.357 2839012.274 2371859.324 1702711.656 2631466.052 530350.4312 1310467.676 1048702.804 1971904.318 2520523.141 3135267.51 583367.3825 2198969.093 2445701.849 3269989.315 2657933.706 1583257.813 10632551.51 7913359.432 5737120.894 14082462.83 22536616.67 12406343.65 7879946.466 11139796.88 4721004.909 20293510.66 11070268.2 10496076.88 7497612.644 14852733.18 23328332.69 29298460.92 33279220.3 30117157.27 13510944.13 23211237.54 25356096.87 24800457.25 15218222.05 17452731.22 14324952.23 21887548.95 25650272.04 16295720.14 16947541.53 20949975.17 4656782.472 9578321.732 8987909.302 8467785.211 9512081.143 8104583.637 3202260.134 10867738.87 9891729.501 11160079.82 12564691 10493050.04 10149743.89 8600113.872 7889402.807 11888604.86 13044035.43 glucose-6-phosphate 26023561.68 38336808.75 49918241.32 65646868.28 81645800.62 89329907.41 10091201.9 23219843.93 37355710.04 20093527.58 28115293.96 43702333.31 11300850.91 27955237.54 31804885.58 36851485.26 40904633.98 47358036.37 23112841.78 32018587.98 43911722.86 45765259.54 59960094.67 72331188.7 18786127.28 43327273.33 30940138.29 84659419.81 100619926.9 118023339.9 19729128.6 34131538.87 34685226.69 29065445.36 25201289.48 33165812.33 24172783.75 40548186.76 37276213.02 36850517.33 40119526.95 44936891.94 25346538.26 47016086.74 41885488.58 38835678.46 47619022.95 45312583.5 43818106.59 42165451.76 61233223.97 44017351.87 51745071.48 58281506.57 41451949.52 54555531.28 42758157.91 58486271.21 63801270.7 67081994.17 52835681.85 84911158.18 74039153.22 83928266.88 83414671.33 96848903 50510649.4 52952696.72 52549448.85 54678175.94 45687697.77 42019497.23 52793144.19 52813343.27 56026259.89 49861066.07 54970327.74 51675906.28 59849543.53 69399749.71 44862238.83 68512625.55 54010764.34 76747759.89 56007222.16 77373993.4 75035572.01 82961858.74 82461744.48 53672259.4 2559155.041 2958006.348 1987645.045 2816680.876 2779670.294 2957641.922 2410902.698 2105246.142 1767328.912 1910361.784 2728145.228 2406698.461 18369039.11 22068077.3 20930974.69 14925511.04 18993799.27 22831014.15 11845239.18 15345751.81 16825027.15 15514514.67 14847339.59 19736303.39 2295978.439 2041888.963 1605911.885 1707653.337 1312143.936 2673388.456 2333223.821 1965209.35 1417397.182 1898352.46 2060630.566 1900788.738 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 glutamate 620436421.8 506696189.5 543176532.1 462626700.4 443791415.5 394249389 501251212.5 484530770.4 433648816.1 437125726.4 361710642.2 338429312.9 493239971.1 421386916.3 373531496.8 347379236.2 348072541.4 303267505.1 650434439.6 434810000.8 409587560.8 358606635.3 354635269.5 299496750.7 684152243.5 534782331.2 561277753.8 536306799.7 472177546.9 406912965.2 465240583.8 352584750.4 348951480.8 245399719.5 199903298 176091374 514445908.6 407017972.9 301167971.4 295876062.8 232033288.2 213159615.5 537960587.2 367276937.7 349034765.9 328268039.1 290006663.1 229571110 582557130.6 369241520.6 319018682 223435496.4 272576209.1 248203469.1 626096838.1 371183178.9 337116505 292414243.3 264463872.4 256129309.7 396621405.7 285540578.4 268395518.2 250766389.8 165547237.6 179171365.8 391175167.9 321995568.3 274905523.5 318535995.4 285979363.7 258446919.4 369819486.8 267854464.2 265099270.6 273519384.5 241008986.6 241716475.2 494711254 211483564.1 259926822 240642633.3 201183363.7 198204999.9 310826880.3 159295616.9 281673622.6 165940503.2 157442589.2 202677978.1 7148600.56 5800028.316 5290970.288 5243980.725 4296515.475 3835271.748 10321772.01 5835202.696 5997528.453 5154570.448 3780207.264 4140055.7 250716614.4 205719259.2 159268326.6 167548476.5 155673250.4 150034113.1 238477645.3 169892402.5 145928644.5 144512545.4 136109333.7 146523291.9 11008459.36 5502022.495 4903720.438 5334347.982 3822302.661 5418874.142 12480354.02 7380628.26 7500153.94 5278148.255 5502628.051 4674697.001 9327309.122 17451426.44 7422916.053 23502338.87 39904749.42 19787247.41 3319781.623 9578553.141 7977514.242 6819616.164 13417480.98 8887848.631 6636509.768 3133745.985 15794337.78 6603296.842 12658420.61 6165839.516 1009403.378 1639879.781 2138677.313 2828656.999 3877794.273 1074442.314 1069029.615 4649370.389 2275315.513 3356034.125 6889065.539 1090132.858 11227967.7 19636691.38 30238629.72 18045605.05 13190026.51 10365741.02 12303614.2 16565666.71 24893865.21 22568147.14 7786457.48 4396857.196 1176591.575 2767929.337 3003346.6 1797795.475 1412442.914 glutamine 327019534.4 347283527 341658061 329462882.3 347406877.3 313286479.7 104882278.7 113668038.2 116060430.9 97995998.13 109092329.7 105011294.9 166288399.9 158830146.6 164944899.2 144979514.7 137605978.9 126465218.7 326680055.8 299484755 290538123.2 308227553.8 289320611.7 221406939.9 293095546.2 317146403.6 329897292.5 337793901.5 313668057.4 307063877.9 163597524.2 176854030.8 163144267.6 130492051.2 120568312.6 116604171.6 55667040.72 69917593.15 73616721.95 38920076.06 53777978.29 64411508.56 123913059.3 131461687.6 122327530.6 91321276.48 81867479.16 81837759.88 214515597.3 181256528.3 166673155.9 133826722.3 181358976.8 110136346.8 153075853.3 168420587.1 160518311.3 152502357.9 158589366.3 179754610.4 190295938.9 208996806.2 200470647.1 195053371.6 186448371.5 185922970.2 54131872.78 81299085.09 74495432.47 48902975.06 66197715.56 81098060.75 106502942.6 107864298.4 106669038.4 96994976.76 89358821.66 82957284.17 189774011.2 187434868.3 167792456.4 144966677.6 182243040.4 134307403 156470627.1 193712911.7 163752930.5 159536508 194324647.2 176589800.6 79936755.95 142502227.1 136304342 159398472 168843439.5 165538553.2 85463843.39 113853196.2 124161906 121353410.5 131264947.9 130086066.6 45138686.32 59455965.34 50700871.74 39277497.76 45909538.99 56932364.52 60725505.04 63340132.07 72547244.06 66824453.53 58182207.71 68834762.62 79544512.04 74745904.28 81963711.05 73483141.22 57859481.39 76294691.81 78217085.7 86188587.29 84311079.95 74030044.51 77394170.28 82611555.52 81875687.29 106982723.5 77901270.39 210402662.9 233565964.7 139030826.1 62156824.75 188323316 62839044.76 267786356.1 130990859.4 194779675.9 61692925.38 151668833.2 198328098.2 225727954 197835482.1 181893423 87232899.64 177300643.3 167917915.3 113434756.1 76212031.61 148065016 97087075.94 102325411.3 110094375.3 59062234.7 105274355.4 98551079.74 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48445.67549 37634.48448 45562.26269 24190.70014 92642.49077 36973.75142 53736.0808 44888.49281 38073.87621 62790.82351 35797.75618 289004.0207 414857.8571 436006.4569 617456.7717 629872.0855 276400.0157 74078.04044 62289.13487 198628.8078 108940.2473 181953.8373 33100.93637 81775.09039 198571.9891 390485.8488 186644.6891 190198.1578 12094.87173 43325.21827 17993.42103 52371.33772 24360.95458 75876.09611 13755.78294 15901.17498 56098.98589 46474.69988 44833.96705 27012.73486 22492.85137 1420897.386 828219.3551 1505626.206 450904.4965 334366.6745 306675.1031 838783.4711 778013.4157 707774.7096 441043.6417 322182.4084 171582.8007 0 0 0 0 0 glycerol-3-phosphate 13243229.47 32409524.41 47968047 46168211.48 52734931.14 46846118.21 13958896.1 33089735.32 44199104.68 54891869.61 40057169.74 49557799.72 16901793.92 29308216.23 32187563.03 47078230.82 63973599.86 59782437.4 17792335.32 15035629.5 30847927.87 55806359.34 59622263.35 63149255.36 18961606.9 38654524.75 18660913.32 94630520.88 94285872.34 39619550.53 4124346.092 4713649.717 4405240.974 3802604.964 4205568.728 3846798.877 6405543.193 8906681.42 7778446.842 11615525.89 11383123.93 10123795.96 6760023.6 7582510.061 6386531.824 9563160.386 13029624.17 10290807.31 6829596.392 1138472.022 5492842.54 8927308.722 8686603.291 8306925.664 7995227.257 5478974.939 6302685.891 9869068.066 7900179.668 9462801.14 32668539.16 14005629.48 21315931.01 20383602.7 24851165.81 29457059.01 25498889.12 17638515.41 24164501.6 50178499.04 41450043.39 26055344.35 27802742.1 12816074.3 16391135.5 25244128.94 28310061.62 29767537.98 45931250.6 16184543.25 24855719.71 26555923.81 32583230.24 20626443.4 48434672.49 15472587.2 37093482.2 42579435.11 34922585.28 51362677.35 2756127.492 424501.4637 493369.3376 546801.9843 747167.9619 1136460.82 2672573.179 761750.2307 567907.1802 387390.9674 570287.5875 425701.2728 20343663.39 11378238.52 10557292.38 24326794.91 9902003.138 10150563.47 18165311.73 5131797.079 5229750.097 4744216.351 7769420.31 6679674.516 4325513.976 1029392.857 1662700.571 1379327.599 909710.6125 1103657.095 5151921.501 1060865.7 969032.5046 821217.0953 1459602.806 1852510.962 792278.7652 3230313.796 3504200.673 3533766.761 9821545.885 8149041.729 1235233.556 1468329.231 1516230.272 1962394.493 2550884.367 1285306.885 232005.8035 1330036.315 2627579.085 1975425.043 1781486.367 1129592.496 452146.5042 611177.4839 1060207.634 853458.2922 1386132.675 536450.9229 0 3384462.123 1066928.814 1799279.453 6061403.12 910997.1287 8746473.462 5693346.964 5661942.195 3969756.53 7608466.055 1349747.261 15142763.29 6937236.337 7545300.608 2528093.16 2984373.823 1892753.389 322228.1952 584933.2602 673300.4523 621586.7688 737818.8818 GMP 1280789.881 832612.0086 782134.0778 706806.491 830952.9415 1035240.728 809587.0097 607476.7327 575075.7401 987422.9979 1246100.306 852263.9903 1129615.244 817211.6663 919510.4482 735399.4141 867289.3847 889558.8637 3406698.225 1513718.672 2024612.603 1521402.641 1856091.701 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4230010.998 4933273.061 5887783.017 5504049.96 5288587.458 2793222.396 2529569.569 3578852.551 2445803.246 3940098.383 7704545.086 12494245.13 11585073.27 11546289.19 8408549.759 9701586.777 4636737.837 6838282.779 8102680.383 6335166.274 7223264.152 4818882.758 25034177.69 35400439.6 30342992.23 46104079.92 31316903.34 36486738.91 58857466.6 32266709.72 49653200.57 25537235.68 19980249.33 55951174.77 24700191.25 18475269.84 20332020.61 71199519.74 23681433.9 25938435.99 51042745.23 42160873.35 59808473.14 57256820.61 68848555.36 84747358.61 37413182.79 44833295.83 79660750.13 59713987.52 59805168.44 70366004.8 6074047.226 6195064.602 5369352.763 5474580.78 4311732.053 7505785.821 9756384.006 8894353.904 10822928.32 7543457.576 15106702.88 7345581.912 3334103.919 2507812.095 2954741.617 3141640.652 3694942.094 4403185.806 16890503.37 15626096.95 14732844.26 10324665.47 12160156 10796729.07 5540720.113 8094970.583 12339864.83 7455520.259 10558354.84 13612191.59 3048920.964 2905740.025 2362092.863 4690560.081 3168424.154 3725358.043 2311468.254 2546759.866 2353936.799 2453130.174 2398946.029 1495883.511 10573487.18 4243957.198 5146529.004 5483403.423 8092683.54 16473558.14 16518423.61 1585468.509 1738483.393 2438189.338 1661810.96 2533121.876 8021964.607 6613688.59 9507300.677 4811154.461 5601747.725 3490726.767 2690854.272 2450860.526 4232577.28 3037786.145 3786083.24 4429914.042 22182654.03 16146153.05 28083268.45 25017763.02 51757937.03 30254195.46 26366307.81 36283461.64 30698824.73 58348779.96 48439311.09 45930263.3 51331521.19 35932752.7 58521866.62 30085712.75 30189543.39 35793972.84 27020970.25 23887146.48 17907957.91 21166449.44 21415507.97 17493104.45 20529216.18 21732891.59 20814549.37 20255625.82 22083122.09 16877228.49 41725231.6 42051794.68 41895199.5 37341329.29 33446997.04 27376448.57 19902403.15 18389377.17 20006711.38 12729554.82 12735023.21 13405821.78 8600124.999 8677205.174 11336844.12 21211687.98 12902105.89 malate 196824711.7 169972811.8 161802452.1 153011799.4 141293812.1 121124372.4 180644782.2 169602388.8 162689486.4 162939789.2 136325124.4 125126373.4 214657830.2 179247749.8 161240543.2 149227709.6 145641870.1 137381208.1 229610056.5 202775610.3 192340467 193623581.2 192442785.6 184487601.1 268482791.8 235037681.4 204535003.6 213806572 191031984 161160023.1 26340053.37 108455250.8 74866072.91 47868646.49 13086800.25 83019814.13 56329093.26 24146704.61 60601218.4 110415672.1 81037827.56 65360297.77 68760337.97 115923244.5 148382731.3 114851995.5 159979977.7 143386470.3 46959384.76 90956574.97 113334872.8 132517738.3 140590088 128159842.8 43319372.64 78595379.12 108736320.4 134726447.8 110487753.1 146969921 188739225 182469589.5 196683445.7 161822798.8 142736010.5 207810142.7 211760878.3 153506281.2 182562568.8 226262012 133748378.8 107571284.5 237426925.7 181208882 183220364.5 222233502.3 211001279.1 152241133.1 265466995.6 181447630.9 134856525.4 242492845.2 217193059.3 204181654.4 316582198.1 218146056.7 243737549.4 253437486.3 180793549.3 122274009 100669207.1 116055340.2 114109892.6 110049043.7 107413371 88693398.38 98818680.17 87550992.12 73635699.9 93001827.9 93986109.49 84277545.88 117791428.5 142484049.7 117664807.4 120996997.4 108472257.9 133988347.6 151332605 133103160.2 131668111.9 109426095 131085598.7 129158360.1 118338028.9 103535352.6 95487058.27 116488812.9 99524683.68 110608532 144175662.6 111684511.9 140248603.2 93907583.95 117523331.7 125248947.8 62769065.06 134084252.7 131333999.5 122479334.8 152520799.9 165520096.1 45600929.5 82452071.32 72746794.99 90910229.98 92928707.32 91267410.31 59649972.57 97701607.24 95683080.35 89066665.89 111899170 113100626.8 15040439.64 43949912.61 40257908.48 44625010.75 42893548.26 38508810.27 24691044.37 74555589.97 62739139.05 52641676.16 82715973.63 73623057.24 77729771.04 116758341.6 119013571.6 94321470.71 84940420.06 91345604.52 76142925.25 103772487.6 104436604.5 78988921.24 94934681.71 86488316 23174192.95 120209918.7 135080959.6 95700297.41 122342793 myristic acid 251395928.7 184897603.2 87124052.61 475931693.1 341951891.6 315249088.2 1451683241 814342503.3 384374148.3 552896128.5 616328397.6 720964686.8 51640064.19 98234952.88 54719219.18 66839437.16 105658676.9 105944095.6 1055258438 911118271.1 736093360.2 1993466620 960914183.6 1317761897 118182324.9 98934767.96 96895527.15 315099630.4 354614291 78947092.25 885199326.9 1991546778 1425677300 3123912023 1023648886 2253524013 3295722603 1399922418 2530332360 1629193433 1230168172 1778962972 132256789.1 165127431.5 191341684.3 202173134 159700649 148349487.3 2678263836 1763422417 1672806303 2302393164 2648213672 4374441993 573420091.9 507541377 281866525.2 297560989.8 391823026.4 618893830.4 179795647.8 280875745.3 372112376.9 378625048.1 168296596 415880544.7 1019301017 1296989462 1808448283 826963710.9 1654748369 1239201278 100061010 54372167.4 70924009.77 55867836.43 79707898.4 55874993.96 1207785851 1454711262 866678123.1 1118544547 1325212322 1184975402 139640912.7 72971063.02 88050203.83 176579231.5 95830513.47 280756277.9 85456522.88 76401951.05 77057703.26 105150034.9 89957323.99 114826429.1 124178192.5 139409383.8 51094065.01 99770842.41 113159726.2 86815313.85 1413686597 466209268.8 985337618.7 824436486.5 1257149423 1814445814 63623083.02 43454724.21 51919702.74 93879878.22 64355739.08 61286784.46 582494255 622845093.8 868394869.6 387884786.3 423582421.1 98341364.23 73333930.36 75815329.01 82703684.26 217835201.1 235580793.9 73691195.68 549290485.1 359863484.6 439449496 384529182.6 485553966 877192027.7 1404095652 3933434507 4255266155 8747452590 7695687803 7936692990 5769570550 5927674330 8966214858 2634422715 4318224757 4202197747 2152970104 1989200058 1635197130 1711974217 2081975707 1688528021 358547320.2 598441201.6 352044221.2 407199946.8 471700877.3 404457350.6 3674562528 3241081970 4513971543 3905518115 2007220079 2672696942 499062155.9 457485675.7 269029099.1 418001840.5 257938359.2 401555114.8 137810279.9 135575462.3 136808436.2 193022046.8 103137784 N-acetylglucosamine-phosphate 2602263.58 2340314.892 3225984.897 3634927.317 5494454.663 6335425.141 1359631.898 2125106.487 2684587.198 3637124.435 3540050.328 3311973.895 1839551.461 2213384.688 2455445.571 3250096.434 3633237.014 3528529.085 3138446.089 2570978.671 3746798.917 4066815.854 4400325.662 3213225.165 3111189.09 3251210.778 4956208.216 6112494.864 7532572.14 7802388.671 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2432829.709 2678675.989 2823080.158 2481827.836 1942728.782 2499224.741 2531711.184 2385786.041 2467646.854 2241637.636 2093590.889 1728716.482 1973396.484 2091370.127 2388096.218 2112965.932 2046390.094 1961502.277 2867444.774 2279494.12 2297507.751 2403271.357 2376906.479 2095991.798 3347438.546 2926847.787 3949244.999 3296568.113 2919420.309 2466610.711 2856635.677 2459411.197 2413085.132 2582207.691 4252509.994 3347865.315 2279454.622 1786608.385 1325925.015 2893619.278 3377606.785 2720673.161 3053089.597 3733035.579 3093004.351 3872280.119 5572632.208 9265126.696 3393194.249 1954821.756 2712736.205 1665180.297 3993033.32 3299554.401 2178800.058 1673560.541 1684825.41 2459437.877 1903503.257 4314913.592 2686120.654 2425200.267 2347509.37 3259619.334 2803768.962 4661530.463 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 N-acetylglutamate 14348588.92 3883136.266 4137609.272 4710006.05 5277143.433 6038032.034 15942826.04 17580600.91 18941112.87 22147398.14 24492301.14 27008563.88 22026901.7 18533505.69 19219821.59 19643287.92 24366717.87 28116514.9 12404219.17 3114079.448 3129530.1 3514630.792 4288988.641 4732039.359 16908352.85 4584631.678 6597697.324 7260448.995 7512144.713 8207558.672 5111597.097 1143035.291 1059353.684 1171567.909 1174388.747 1329689.154 9583658.578 8451494.43 7658638.109 6762379.759 7428761.062 7678553.029 14626197.24 9090346.708 8546229.16 8951093.523 8824735.723 8342385.588 6792093.142 1216611.433 1317746.326 1208730.096 1752562.937 1670383.249 8603649.166 1455966.785 1863221.054 1777165.092 2422414.669 3247187.861 44847215.06 9840165.626 11896180.32 9936789.752 10513078.06 14023751.58 46010040.53 62073673.57 66095832.36 75621221.98 60804400.97 61558230.88 63640697.78 69655595.07 72238201.53 100479841.3 102348171.8 91482434.53 38402034.88 8265704.97 9501496.983 13434919.91 15404467.17 12745021.89 57216004.61 16534184.07 20742613.7 20524988.72 19297889.88 14452937.97 351183.5539 273898.0273 239099.5817 492481.4947 849831.1383 1028288.753 493932.3053 191773.1899 164453.8742 239179.068 301389.484 575924.7505 6191023.692 5989172.992 7478870.647 9437548.959 13960837.75 19145486.06 8927270.529 7777881.883 8310166.474 8306027.073 14660565.91 20001511.9 424501.2934 140396.7581 153195.4611 228996.6362 192515.8087 354689.7818 559153.9985 220734.7695 307376.7909 469748.8143 781997.3702 663177.783 1468384.274 4463029.808 6712056.571 15573571.66 64721840.29 78213057.68 1858304.21 6352217.086 9744516.305 54557736.9 73745869.25 79630958.69 818768.7595 838290.052 3280696.373 26406165.81 18474241.79 21030851.37 456685.8271 3122516.679 5981273.339 16169337.18 16163777.9 19034344.3 1544246.346 5083333.45 9847615.88 16571887.59 27070454.3 42403113.27 1425274.52 670314.1448 14632726.62 1488068.778 1356868.532 27008581.76 1440097.623 948454.6128 2528383.122 10802574.67 8584635.303 13994430.98 408539.2092 3295306.707 7422489.685 21382773.07 19924814.43 NADH 239965.4614 297767.5621 290879.165 415884.1894 323536.6891 412995.784 2065419.787 2745735.312 2644124.015 2298290.682 2224046.477 2404743.145 803271.0968 2725405.517 2999650.69 2807064.865 2598295.232 2948072.315 372422.2212 240866.4651 182448.7087 251532.2571 358877.6432 354370.4091 0 376582.7224 36203.33982 365640.4405 279242.4074 99903.63706 319814.5198 222001.2437 199114.5138 235336.7541 406717.2968 559260.5276 511774.0094 701112.6117 1481365.917 1178768.097 957119.6695 375594.3649 1047974.264 382641.9644 1137280.492 538398.1709 598554.3622 1646907.284 841772.8601 0 290405.9013 500371.336 878450.2977 721043.0821 909976.1556 677551.8574 616859.9799 779239.2799 638334.8043 628269.6168 921294.1939 650987.034 729802.5052 755186.4093 913913.0316 1137039.455 1031997.537 1629710.877 2043766.653 2605305.213 1898089.053 1681390.825 1290953.364 1862877.265 2002827.133 2412385.252 2259634.422 2277017.346 1705584.979 626800.6033 852427.596 1149253.582 1504437.192 1987127.787 2531811.758 1031786.242 1318609.111 1495279.843 1590623.135 1415498.755 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NADPH 762474.1467 881055.6168 946888.1505 544810.7463 393460.1619 460494.6757 1229278.828 1036523.985 1050792.502 1266889.343 582738.6634 382967.872 751177.4227 844535.7279 709800.0274 659091.4455 684785.4894 462056.4918 1912856.941 1145121.778 1069018.677 1118772.5 1016478.974 1218997.137 2223426.856 1141800.098 690549.2781 1316714.172 1241184.354 1421810.375 25577.51181 196585.0742 39640.92395 0 0 46183.67026 208125.9407 0 155142.9742 477181.4974 364671.9418 90684.07351 0 180624.895 355717.3839 49676.01479 443217.8213 48830.85509 300247.4166 21424.27458 851855.3434 664328.0714 975306.8856 1490551.597 386360.3546 325020.0151 465854.8052 860823.1905 482760.6325 1117973.722 183057.7716 240415.4902 264438.8602 137168.3922 97759.03674 416352.0426 678272.8205 1633008.427 974876.8175 1496297.839 654817.1906 300360.5458 974571.1742 827008.7325 734716.3427 1003715.474 568761.4904 335551.0533 1404210.484 597477.4278 515583.0196 1438103.687 1097122.835 983105.911 2016016.859 867983.323 1732379.042 1676615.19 1553287.438 894702.6127 150089.1876 0 33129.06373 34410.95311 76986.33809 39731.05001 0 0 15196.91083 0 0 0 297056.5174 203273.212 59447.31192 275873.4324 84610.7029 4502.496744 31829.07233 15120.69182 15435.99896 54950.13384 0 38646.74607 192927.6969 0 0 14934.31396 8897.026224 0 50907.29674 29999.91453 133873.7915 0 39664.51941 128034.9272 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 oleic acid 47516405.55 32741086.81 84805918.85 39013358.32 30686238.11 34836746.41 18308132.83 11386478.39 7790878.368 8306402.831 7288983.906 7893056.827 18693927.35 13092928.6 9143850.113 8994801.391 8219568.332 7933505.275 33448837.94 36017716.84 34453469.17 33454546.2 32816421.11 33276976.61 22641910.27 30498747.38 39497030.19 17667633.1 19462085.78 19713567.28 65454744.17 52675407.09 50078452.19 57916032.65 50107085.16 47644741.33 54420534.94 41999127.59 65194990.19 39307246.07 23363435.45 58459679.58 31981335.93 36777511.61 29930119.08 65158936.58 33082836.19 29473535.21 85899548.48 82806006.78 111895055 83000381.68 106730633 103034990.4 53941957.6 56541765.21 102425383.8 91079875.85 81261150.05 74159151.43 42994812.06 38228303.02 35406025.02 37515074.36 30253399.82 37550369.77 10961443.8 12523751.16 10290167.6 10196723.83 15969140.92 10705055.67 14412670.52 10007723.77 9919972.447 12258788.01 13114448.81 14649363.79 38695394.06 36359609.71 40238326.82 29125840.4 35428903.64 35685505.8 20040130.22 23023117.52 28213585.47 24707124.47 34591717.18 32418770.1 28144364.16 22390113.92 18705195.51 33291479.02 38251890.05 32377463.25 37660569.93 26245552.74 74233095.38 32331930.03 39119185.19 31047972.16 17991955.24 20511815.25 20591134.23 28621783.11 19262438.28 15645176.55 31817804.27 43488051.11 36977025.39 46385938 32318564.73 33509517.93 52651628.16 39690088.49 76793692.93 89024567.67 42379104.17 28316415.04 25800285.91 24218195.68 40782381.56 39912127.76 38815042.99 72424143.51 299677853.6 223424888.5 456097813.8 328244050.4 295785624.2 434657066.5 627793306.9 411124593.5 339276407.8 318583953 343091664 471258055.1 316613524.2 283297505 303881946.2 224904278.7 286019896.5 318670083.8 203118742.4 178587467.1 149952606.3 267461839.3 174309430 161940714.5 247064899.2 361292785.4 258742083.6 333343970.5 343707997.6 210059523.9 376838969.2 441285949.1 532245457.4 517507236.3 695919018.4 299308843.1 192494820.4 163526998.6 201336381.2 218916511.9 214338864.2 214620999.3 175464839.2 199023635.2 281708012.3 274904370.4 326921287.1 orotate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 79651.48233 11390.97562 28766.51735 34547.3198 7285.118699 17303.29442 33349.25434 48904.56909 38566.90715 23271.72981 36777.28323 3158.44662 31584.47052 42132.92199 45406.15962 89727.01681 57477.98328 104165.6626 48058.52566 41223.40612 47041.56234 34295.34222 58302.17188 56625.06757 79914.09571 45997.20152 49719.44065 40362.03978 33402.55856 42974.89802 68192.70224 55281.77223 54605.35662 36592.93568 53391.44971 67229.01046 447218.2297 0 0 0 0 0 314111.1716 0 0 0 0 0 283838.6219 0 26919.72232 150441.671 0 0 417112.2736 369138.6605 327153.1444 374227.1877 284883.9708 230254.0089 614302.5622 470416.5992 422149.0258 367932.9565 380586.4382 295936.8965 477210.9059 151003.0329 406593.2701 284057.3459 0 224401.4405 432551.0616 240596.7224 200126.793 212703.0742 0 0 407267.173 432223.512 361026.9929 258900.5135 207561.7758 palmitic acid 331453758.3 256960691.8 416042615.6 264356226.6 320837399.6 246577077.6 190447720.3 160698876.4 111544326.9 121159540.2 91982152.04 92490731.32 197183227 159546274.5 128857412.2 181452977 130145226.4 147537153 323042434.4 404566381.5 373120199.9 375665808.8 423484384.8 342325066.7 257352861.3 339456412.6 303086438.3 258619846.9 249147517.7 218022357.5 1538418601 1463143357 1390190770 1484060880 1560755427 1568224846 1069026301 970732730.9 1328384926 735362391.3 647349239.8 1304281036 864151105.8 1007070504 847744329.7 1413784172 953126752.5 925757480.6 1866401036 2102089127 2620925684 2417361859 3165428991 2276156534 1655317221 1554708529 2546213473 2607834810 2142199697 1790135607 415334457.5 356446111.6 341038626.2 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1322408717 1934282779 2070433887 1708136344 2003653535 1836094333 1293731032 2850605032 2638454360 2173388142 2001892613 2280908133 1791272107 1156234283 1093950903 1253292563 1112622136 1142874572 1239709497 1521239099 1256238002 1508800180 2671093036 1067826462 phosphate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1173.003992 8463.688133 15798.92345 3812.535976 13269.64829 0 177183.8052 268990.7952 214144.3243 77674.64312 121323.5824 95616.00906 252890.5577 74149.81288 110596.9535 141974.5945 33188.12266 114288.3865 0 292590.1259 25338.71926 15007.7305 18619.98842 18503.11742 34254.92294 26548.02176 42154.15384 9791.792119 6937.443242 45918.03401 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 205454.078 104396.4715 124255.4112 148126.8794 187886.1929 335924.6161 689386.037 588943.8854 545097.517 511822.3766 602672.2481 476531.1967 873434.2287 880943.1399 947979.4579 897868.778 782895.5751 958603.9031 809602.9159 745330.3312 704484.3461 723577.9631 679214.2396 851761.783 64307.96681 286526.0368 317962.2159 320384.1551 212875.7571 212050.1631 184964.1743 439800.344 556124.6549 467125.5713 402801.5568 299168.8653 9439.56332 16768.67523 14563.84444 0 25015.32941 30237.07554 3214.713939 8112.753561 32283.76115 8060.283637 15532.40162 9725.300259 5095.067316 5387.657144 22844.95049 17458.65022 0 0 860555.7135 812064.2099 849432.0054 1054467.606 667232.2875 1023860.598 976341.1713 600250.3544 1012493.348 631077.0954 887935.9493 999255.4132 14839.55162 0 54007.02293 21553.27128 0 12275.60264 10219.12451 9862.425107 10494.82429 19107.51811 0 13855.83709 857067.507 1020599.533 1116631.322 912901.9919 671147.7034 phosphatidylethanolamine 0 0 0 0 0 0 17718.39882 0 0 30876.16233 0 0 65852.04361 24449.9716 53875.19358 53999.06455 41422.14728 19613.17609 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 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1600220.839 1262892.327 991036.8158 597308.6429 461561.7485 5867383.474 6664679.743 5312489.239 2982263.185 3205703.895 3638342.813 2494096.168 3226999.195 3961745.768 3211120.303 2266504.095 2610736.105 6359200.456 1931057.703 1704510.355 2438648.992 1593200.277 3440961.474 11967272.1 4301844.661 4407676.143 2212605.178 1760408.595 1602679.593 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 phosphoenolpyruvate 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 82801.33304 155015.944 75976.34719 34787.05854 0 95882.49829 2587351.034 353781.086 1014936.658 2331579.702 755158.2335 758175.5217 2724126.513 1734373.951 2568455.72 1203791.734 1612259.393 987103.3749 104651.0222 22972.60957 105801.9751 125244.4971 245711.6213 215723.9898 102892.9743 94193.66151 103737.957 124059.6092 91588.07069 135651.8266 235203.8203 90149.54334 78478.41235 60299.33792 52530.9277 120363.8031 1345991.448 1411540.99 1091324.961 1768003.683 1325502.21 567769.4086 704151.3288 1012592.551 1328922.037 1261923.648 1217258.912 911340.6746 301348.7642 101012.742 71396.86422 158657.8743 156169.2109 190503.3505 805560.0395 211111.2391 320869.3198 276260.6088 280291.5431 132842.4799 103037.5888 103259.7965 59779.06176 59877.96223 108782.9779 58745.54457 114564.4388 76369.74951 83098.35881 50392.04435 65502.79061 32579.71617 2904366.844 4236838.88 4002074.394 3086827.952 2561711.573 3164906.569 2317438.534 4164528.987 4946501.261 1965833.717 2649415.827 3213497.773 131060.1498 60217.73103 64534.51367 106169.4267 53939.86981 79447.23476 224638.1781 98270.17533 126560.7737 94578.34404 109479.2133 118867.9401 53722418.65 103850982.6 104469167.9 104482208.7 66461383.09 40518276.43 21472581.66 25277313.55 59247090.82 32364783.1 38233845.89 6624057.999 38256321.11 39963510.14 63171128.09 33554530.5 24430832.38 611312.6109 874241.7812 816057.3405 5799972.264 1970158.535 6782123.32 378065.1366 531501.3863 4489748.169 3579718.523 3347523.89 5159483.049 303583.26 53768831.37 93877062.01 66196139.48 71871800.28 57086551.53 46255259.2 71540498.56 82032332.85 96959153.17 53269939.51 23873817.15 30510509.74 641507.6684 501227.0052 721027.8244 426421.0239 970808.5054 phosphoglycerate 2531550.241 1299351.519 1440279.226 862324.4145 646698.4688 751239.8016 3908849.617 1861779.059 1864869.209 6606818.526 4177924.625 1730928.173 2807566.272 1420774.913 1553398.337 1111919.016 1776017.566 1425842.06 2474707.46 1877381.741 2520719.489 2986133.996 2984841.017 1963289.286 3956276.423 2136686.231 4758874.972 3609498.066 3449269.076 2769365.985 85455.85771 829986.5941 129899.681 41582.45332 23658.09032 147099.1298 1555318.23 88247.53139 619593.0397 1552545.384 513285.7697 465810.6093 1301031.036 1204815.089 2148620.376 798537.2482 1549098.101 828325.6096 101394.1836 65698.98337 205194.8742 429690.9546 549997.7242 1008392.092 96345.16468 103324.6404 196904.2116 384591.1453 186665.108 507710.7237 5469599.174 2352376.372 2737660.522 1884192.225 1117879.849 3179746.929 10787082.25 6725342.37 4880607.02 8408486.019 5501727.504 3016064.076 6475786.442 5112746.448 4913904.542 5453083.163 4292130.618 3498648.666 5744608.253 3094290.75 2369605.043 5453195.279 4873862.242 4066106.322 8725215.534 4406989.03 7103011.27 7108129.079 5690774.439 3290384.797 4203999.123 4607295.539 3652611.446 3883655.495 4597954.813 4218341.156 7942501.192 6389552.112 6193018.9 5178235.411 5356014.393 4678685.62 15405649.26 13915349.06 12549237.57 13625314.07 13536247.53 13875013.67 9795504.65 8617168.848 10825241.83 8592172.347 8113112.546 11334484.69 5897509.806 4529524.073 3632718.53 5795476.32 3787759.293 7295138.102 7556078.795 7472615.03 6944359.91 6783832.317 6371437.763 5130475.543 14598859.02 7328819.491 2605227.487 2724220.408 1480349.844 1795602.368 432057.0252 474570.9167 1529321.385 996209.4319 1058011.724 252984.5182 556180.6012 825542.159 1250424.232 786990.3905 227523.858 183224.5053 2229615.354 924981.2345 2995994.542 1538902.978 5044698.44 0 743107.8742 2594501.118 2278963.602 2122277.691 2326665.451 78686.82347 1484108.801 3159818.377 2705631.929 3055078.177 2842124.581 4791265.953 2850563.802 3209941.535 3633070.204 2485029.262 3352801.588 1076545.146 404713.1341 310725.2041 639628.9919 95252.02604 425623.7238 phosphorylethanolamine 124778200.6 122941224.2 120863809.7 115622395.5 120893512.9 115354845.8 148600723.3 137862901.6 140790003.3 150199602.2 143388961.5 142754007.6 137345952.7 149616425.8 148151607.3 138707547.8 143613242.3 147217579 131997617.1 119636342.2 124470622.1 126526795.9 124621059.6 123667022.6 144958915 147443768.9 168174307.8 178837215 171866442.6 165182008.5 21935225.48 30768941.87 26644854.04 24322983.79 21758821.39 26557005.23 36900320.11 29413177.01 31043712.22 35681922.4 30993742.55 38871317.96 30258456.3 31114876.69 30920387.14 34882027.34 37315407.08 36155080.41 37717925.63 36720911.74 32686220.34 31750392.51 48875266.61 43055500.69 34840729.3 35755965.93 39078962.57 40368069.31 40277643.68 41813099.45 55123838.04 58484693.34 56658182.66 59567739.15 53182427.67 44517626.43 46353804.99 44753787.09 40461246.36 39335553.95 39304991.4 48202199.81 47413198.89 44914427.35 40002785.88 44709010.28 43330071.82 44923869.83 90425661.54 72389670.31 81369785.73 71854653.81 78660542.83 76599587.07 107079796.2 98167349.6 113600237.2 112612053.8 120237656.5 92479381.22 66230075.64 58570685.06 61660016.22 64198952.66 60904528.87 64336314.7 73398961.53 73841260.74 62991923.2 65701349.16 69538830.09 62902615.71 74346488.88 69893269.09 66187430.01 72279883.64 73467745.18 79519270.14 64965989.93 58037646.68 54644223.9 60317417.39 52900537.32 63281785.48 67493417.69 61054938.79 61587652.96 63498004.24 43003837.57 70403294.28 93015908.8 88390659.59 87050128.57 82802324.38 84885679.1 84012009.24 83478.22153 941875.2414 733141.2896 1556345.655 1315092.162 1430099.499 326492.0258 488856.9287 703460.5166 646986.9802 1015418.428 461138.2114 484167.3949 526004.9332 969735.3972 591569.839 623583.6539 303902.5206 0 255486.4133 0 352799.0316 256682.7723 184549.1858 0 364422.7604 225397.4138 253376.2395 891128.1431 201771.0834 858758.3862 1411364.664 1433507.095 1228973.579 1550780.653 556277.2826 1677764.273 1853065.651 2137463.868 1736551.529 1311744.782 449400.5689 0 252999.645 213474.1031 247896.2006 219328.3552 phosphoserine 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 187668.9885 162967.925 62020.06541 16794.9279 2422.895693 20947.81938 213705.5158 32835.28384 46350.0704 39624.31296 26882.66646 35799.23466 166595.2186 47386.47472 45675.72296 41127.01781 22393.25465 34151.04324 309806.4065 102271.4022 90534.14242 97635.44788 89852.54577 58194.53386 279526.8316 131634.8193 83884.04404 49837.13756 20974.21443 37849.02766 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 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2638215.745 3526819.888 3749706.054 4015126.336 4317163.606 2554196.006 2983553.391 4288156.658 3720631.364 4551187.635 5263762.41 1599299.253 1811717.369 1868457.237 2261631.506 2278461.623 2568018.672 2138761.054 1845177.459 1769089.027 1969586.235 2537395.075 3158910.475 1991790.407 1611388.573 1593181.178 1684538.724 2106058.77 2426926.651 3421848.784 3553098.674 3554485.547 4539556.834 3193873.995 7001628.163 2642877.391 3885881.896 3678804.401 4849836.961 3797709.351 5094800.258 969603.09 1856475.135 1840272.174 2413857.281 2353438.827 2969621.703 157480.7913 380031.628 220784.1943 185254.3812 491245.9369 610501.2595 228341.2766 258665.5428 389793.4013 262876.1571 366825.5953 579678.2729 1764457.866 2777207.73 2996007.491 2333987.898 2799433.798 3001068.314 838946.4287 1859495.665 2555832.951 2491457.975 3716893.967 4416177.495 2235911.135 2888671.142 3157965.692 3678874.332 4603821.428 4969994.428 2051888.496 2973187.674 2504544.63 3234009.027 4268650.809 4165764.056 77374.20904 1337291.848 919290.9619 327850.6355 1125823.119 1074453.725 433666.9857 763526.7869 596236.6601 664993.3939 594635.6179 973850.806 1764104.637 3322303.162 3544739.109 3196248.283 2419997.038 3160103.603 1260184.291 2987063.535 3299210.196 3469869.546 4239266.305 4817787.741 1339006.731 1812271.229 1919055.614 2020665.965 2307700.9 3076487.991 557478.0718 1554460.357 1573612.747 1909657.693 1636425.697 1851762.884 3956863.062 2909040.493 3122735.235 2424956.706 2286940.307 1993695.595 507379.3289 214081.0329 214989.6026 238109.5934 740440.2087 120190.8791 348852.3133 276009.7882 187482.9644 278041.8922 340170.6056 204784.2708 1080956.608 1738353.684 1434194.902 1323591.758 829673.3853 1816721.37 591800.5849 1773033.888 1756830.931 1128594.234 1170432.553 1191370.91 2123650.55 2149363.022 2672973.779 2310349.176 1181637.383 quinolinic acid 34521088.99 34073595.39 34560142.83 28596539.61 29151241.85 29571071.73 67052769.64 65816197.03 65830527.95 61285889.1 57403762.7 58889238.43 99648474.05 79652894.96 78300200.88 78221011.25 74707974.49 70473331.09 34160029.79 32824404.85 32060037.14 33560451.64 32448292.52 29467875.17 35286406.26 34751667.26 34204960.02 32935487.54 31953072.55 32464270.92 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 77119.79337 78463.31869 75195.06405 65866.74507 71064.7909 149010.7815 0 0 0 0 0 0 0 0 0 0 0 0 75229.39474 64840.926 73911.06768 110188.7579 108940.1033 147340.3959 127034.7591 84998.42729 152125.8708 164971.9375 170669.0965 142795.7586 4211676.8 4402123.188 3845760.413 3941758.831 3255029.493 3124294.415 3729121.952 5732930.487 3793225.836 3292266.32 3113048.137 2674482.995 24490841.99 30725206.15 25858952.24 24916820.65 23136203.21 23628421.11 41573446.24 29799378.14 31047812.56 30676056.91 28932825.66 20888931.86 4716380.936 4729589.921 3907923.288 4858672.469 3414517.121 3493041.046 4396802.25 5002629.548 5300070.981 3968642.527 4592828.457 3766798.21 1482583.067 1511435.24 2097858.797 2345224.401 2289018.024 4077553.261 2213791.783 1467940.773 788267.4014 2075025.924 2443055.025 1722261.716 1552377.655 1241643.664 1565987.797 2201612.823 1190694.517 2130058.174 3027445.753 9322773.451 5446896.099 3758522.715 4275289.914 5012482.427 2114017.268 4774253.401 3852599.84 4077053.767 4286415.679 6322776.143 2004696.589 2542541.66 1744712.238 2421501.934 2080213.168 3205824.404 2359988.703 4139110.423 3949466.292 2958876.272 1943553.983 2634787.309 991687.4514 1440507.626 2147547.753 2934029.545 3770912.231 rib/ribul/xylul-ose-phosphate 1189342.117 988632.6906 1517430.427 1310779.746 1496416.258 1625588.816 1170028.264 1381176.944 2554102.797 5434457.703 4561182.636 3825007.273 647816.1661 723867.4314 772182.4001 1006130.798 3200284.339 3149288.336 1282343.625 736081.591 1100963.608 1234819.945 1340798.737 1237289.112 1096776.788 1174772.778 3367968.816 1922758.748 1662299.267 1507141.209 1862894.552 2576481.227 2347046.226 1774501.718 1309120.484 2254586.649 1170622.656 2690536.296 4209757.222 2383792.165 2226984.209 2141350.148 1586001.233 1131483.065 1299134.127 1843692.883 1849550.148 1824753.516 3246501.066 8617741.561 2682753.283 2194953.514 3877801.756 3430346.619 2845101.659 2788512.045 3305775.923 3748844.592 3532036.894 3994755.986 2263085.236 1933682.053 1771234.305 2008930.837 2010508.213 2506117.309 824478.5551 610744.7831 734486.9219 1819876.065 1212147.22 865337.7384 915621.2041 618122.998 911091.2687 814255.8411 924725.533 1011650.023 2405157.439 1706886.281 1739409.706 1597928.828 1419553.39 1520017.59 2369631.383 1942669.054 1999740.579 2413499.936 2140542.095 1320984.749 8111022.674 5037322.482 3700352.465 4017330.437 7218092.959 9364057.872 14055041 8779130.174 9485851.02 6108355.802 6051852.524 5613233.902 2878761.791 1449392.561 1581737.507 2167015.66 1449785.124 2278466.295 2878811.549 1516968.462 1702780.11 1245277.76 1626004.604 1842715.19 4949188.626 3910917.068 1987563.002 3369641.477 1751831.19 3971245.413 4818653.597 4536658.572 5501573.735 3759234.776 5042748.119 3521995.022 2761726.798 4181936.883 5708098.052 3957012.314 4931643.044 11165559.96 1139565.353 882212.1507 6407601.442 814311.5735 2495615.223 1313879.159 1048975.32 1009324.618 1772532.442 675852.7887 886427.9203 786661.024 971711.8434 1617156.371 647452.8007 668112.5051 338185.3445 294555.7592 2469676.907 304151.6479 607329.767 263862.884 916062.5163 322050.3397 15374813.78 2174536.332 1779150.305 1605764.932 1506593.113 2230683.643 3769185.641 2265323.097 2360377.908 1849325.61 1885142.485 1637011.572 0 0 0 0 0 saccharopine 938.1110058 0 0 0 1142.580614 0 86631.75816 0 79423.28913 85472.14533 43244.45608 23962.96147 50237.60447 16900.22914 13665.33178 7972.82867 55601.7558 2338.282395 0 2634.411509 0 5518.470418 0 0 0 2562.418493 0 0 20864.62519 15509.57702 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 S-adenosyl-homocysteine 40741.1285 23510.14273 0 0 0 0 1624806.146 1739400.951 1441359.662 758996.532 1268379.926 1408121.68 1717203.924 1886709.42 1892217.371 1545322.95 2451454.929 3973801.225 129326.1758 0 0 52950.18088 49010.85969 42837.62089 0 0 0 0 0 0 239215.4654 193173.5637 158234.1431 167024.395 117675.1641 202223.8039 1014407.747 324439.4919 464935.3315 887617.7854 452656.634 596507.8271 769986.8969 509060.686 578941.5663 602735.4892 1363166.434 900141.9613 400494.1344 849038.6295 372839.1421 316797.0933 413077.1251 473544.235 323732.614 245678.8203 351456.9696 337371.7113 248069.4943 437529.0106 1450909.291 1133728.764 976231.7107 1060069.135 1202682.013 1307972.843 5109774.836 4236664.844 4155154.964 2633209.399 4977030.719 4801431.859 3785588.039 2892400.837 3944245.208 4001880.718 5321502.807 9447593.257 2460306.986 2841470.697 3173199.194 1962623.819 2527501.171 2601262.113 2356610.106 2607649.319 1811720.467 1975886.926 3056139.471 3446903.472 0 0 0 0 0 0 0 0 0 0 0 0 394779.0099 225787.8 217176.999 311543.2739 227332.1342 168237.1551 334501.7577 188359.5516 203366.3747 214883.344 152282.004 208650.9618 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 112864.7513 129864.5332 294511.6167 342448.0102 201782.0344 SAICAR 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25702.48703 31537.93934 31300.08165 31204.18197 24991.52867 28368.75383 31818.05686 30729.48159 34614.90584 30681.43182 38021.81764 49806.73927 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 sedoheptulose-7-phosphate 10589153.47 16917818.26 22207004 40642832.98 58227616.76 77134054.65 3512219.156 5978072.805 13272062.51 8354594.277 15574629.47 14973404.73 5702347.73 9605613.851 9325552.417 12100324.38 15332890.42 16905398.39 17264306.03 22903480.06 44551670.17 38567829.48 51069470.1 49441073.32 17654544.3 22453927.84 27475831.28 78128133.71 88317395.3 163994908.6 5635613.868 9199744.726 10158555.94 8868422.019 13421220.9 15609639.46 7798865.635 7301277.855 10159282.91 8367939.687 15396140.13 17039775.04 8253304.309 16755137.72 14190714.38 14911878.89 18287697.85 21244509.07 12453092.07 9882974.757 21929311.21 13643733.2 19991262.87 21138886.09 13497858.54 13196904.12 11011320.6 19278302.94 26908626.71 41813015.26 14281545.53 48577832.07 44200726.01 49867016.03 57904106.4 67876523.92 19186734.78 48160455.95 36058945.58 12689105.79 28846443.31 32081872.01 26301712.96 43562686.21 43896683.44 31480184.88 34896370.43 30880227.78 19073028.49 56810031.97 32120988.87 20750926.86 22409055.06 29946936.57 20181408.6 61291057 49507763.95 50283429.22 71322085.87 43159861.28 3688961.186 7350948.405 8274043.13 8575075.432 7237393.673 6125474.437 4329928.003 6784580.638 6250527.302 6818997.645 7820379.499 6619817.344 5592120.822 7836108.592 9394845.271 5165143.576 7684016.021 8884141.697 4760281.598 6610219.492 6912121.709 7918522.204 7363652.957 8832878.258 3384657.634 4593408.599 4652641.446 3729053.191 2981746.816 4510160.179 3721939.459 6089948.801 6556588.454 6579361.387 6745041.899 5837716.577 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 sorbitol 4118031.003 5276921.195 6210219.1 9350181.288 16084439.73 22730254.24 2937832.908 3782866.359 4006985.911 7463191.663 10436844.39 14020857.78 2559039.108 2729790.218 3543557.007 4735281.742 6771263.446 9812693.06 3529323.804 3793601.496 4122519.746 5900592.704 8369747.175 10996458.5 2524088.026 3489594.518 3641295.234 6294737.102 9391124.223 9818700.608 4476152.824 8806631.705 9693643.99 13392617.25 18902168.87 21820054.82 3269683.43 3685157.121 5632536.401 7836402.946 8287453.46 8162713.943 2514177.978 3645765.671 4069593.406 5892187.503 5975079.718 6312643.937 5846948.19 6336901.249 7598382.226 7741154.824 11032450.89 13069108.02 3720555.961 6261007.287 6591555.554 8714944.178 10787322.19 12657218.71 1655546.785 1400394.613 4009182.294 5633503.159 7634392.713 8182695.917 74476.52023 1292797.277 1754730.146 2058271.328 2316727.573 2622258.139 829969.8752 930146.921 1071746.87 1253413.195 1731020.001 1823879.925 1754988.016 114700.3568 725092.075 3369958.454 4619515.755 4737492.008 1373826.252 1764936.966 2779002.428 3599727.754 4002400.155 1708124.625 3365350.239 5467814.911 5188426.097 6856971.009 8138664.361 11371197.83 3068995.902 4949325.794 5056662.786 8436742.154 12790332.55 15641837.89 2488396.09 2821737.376 4004443.577 5127133.854 4997764.162 6258389.052 1720602.299 741314.2868 2033806.533 2389162.654 2992423.317 3311744.946 2110135.651 2878266.672 1946703.545 2986559.578 2905890.806 4109039.257 1475402.954 1577838.623 674789.3513 3223625.332 1287482.328 3554721.023 2916171.938 3371371.15 4047579.608 2369716.199 4263934.778 5157188.066 1860069.571 3351407.05 2962160.816 4830068.334 3762280.497 4970187.493 1524337.379 4483175.489 3782458.561 3101509.433 4045254.421 4940881.019 1444399.687 2345801.508 2473429.983 1927682.044 2264348.814 2925773.184 118860.2916 1417581.291 1785731.146 1670855.35 6784070.884 1642011.22 2191350.145 5421914.059 3493881.322 2909437.142 2640751.905 2928595.048 1853988.523 3180747.678 3489944.967 2887057.553 3250101.627 3297834.855 485428.7098 741218.4722 970049.3242 1352466.491 1312896.627 stearic acid 173750721.9 143225048.9 254391398.7 153382591.6 181971306.2 153344270.3 106204260.5 77977328.87 52206269.31 55100122.3 42392908.88 35999981.54 105903803.9 83756256.05 75596349.33 102937079.9 66349176.95 79710925.71 159770737.8 252985700.5 320833953.6 230220499.9 257274411.9 228907282.9 129709517.2 178255231.4 183682872.6 136379900.2 158043393.7 128852140.1 1440114486 1286016969 1365950040 1204620708 1155839410 1278229541 709139635.1 802972570.8 1233442130 499497260.9 496285553.2 955402409.1 873656038.8 947639120.5 650670605.2 1066600396 896248902.5 977422725.3 1351548324 1440129576 3238469841 1839303362 2195155041 3769511927 1092358438 1146278341 2051553257 1943034488 2241374952 1204931126 258213054.5 233232471.3 225671871.2 282248160.4 220838646.1 250287267.5 56675590.94 109698768.6 62980024.6 67285355.03 76155456.32 81896119.04 118166699.7 99347424.4 106336375.6 102762171.7 91658108.86 153232883.5 323782571.2 305032006.7 544938087.2 357022790.4 380981564.2 408030435.6 169133656.8 150041086.8 221762819.7 212960559 281482783.4 311220440.3 77281947.51 75111918.96 45593684.75 74518202.69 120128617.5 94556560.8 102748934 72898422.08 181250293.5 96075117.21 107649594 85378716.56 39671700.25 38095577.48 46441770.35 45140696.83 29267351.54 32529268.57 94081191.38 67921697.83 72412962.35 90794237.52 63972848.81 74941904.03 212381618.3 89164978.73 148511721.4 137804709.6 104611440.5 66717929.16 45864342.6 55756988.39 103422496.4 49246710.4 82217017.45 180252328.1 851586250.2 781717837.5 874565998.7 1079098174 834907319.3 1018764128 1274626202 1180490390 1116424951 1286728751 969779292.8 1153231663 1172377569 830280249.8 1171534211 896822553.3 1186030853 834267455.9 1008290612 490119624.4 475109636.5 711394264.6 474988849.6 768681894.6 1352478850 1289255000 1176835261 1332218387 1185134939 722348951.6 1064392143 1006459399 821810041.1 815284328.8 903036206 638264900.7 371501148.8 377449397.3 467129215.7 387786059.4 384779347.1 466258993.7 773305423.2 609211291.5 714539730.2 1517246629 486757573.3 succinate 2577494.452 2552762.991 2423028.795 2509722.946 2209280.722 2399175.098 4616794.544 3686338.123 4010531.278 5664674.197 5006688.682 3421117.953 7279848.614 4312868.764 3707256.904 3321999.757 3312996.036 2721745.511 2970847.663 2467732.149 2382808.635 2338846.305 2450136.852 2357117.809 3102349.345 2911365.591 3003591.14 3032873.756 2721557.347 2819287.705 4387611.52 4425451.603 4626376.303 5017510.126 6928636.493 5077553.281 4771841.573 5908858.049 8233936.904 8583380.898 11501825.37 7528630.704 6532327.974 6746510.9 5055053.575 7125174.658 6780889.77 5069565.756 8186503.72 9078811.061 10191930.79 12791472.1 16538471.77 11309622.74 7147129.324 8077896.951 9226986.73 11864686.26 11789021.91 13573102.89 12311157.96 7798208.972 8492058.424 5754208.224 6012927.015 9540412.822 8236045.508 4732262.901 7697059.286 9023443.172 9829342.584 4510881.272 10481694.15 6539074.715 5128055.264 6284303.408 6422685.608 5648817.625 17389220.54 10334320.99 16177572.6 12764027.32 15026625.67 7430467.065 23861689.39 10508595.18 16489478.19 16613808.19 12411123.35 20051869.94 11341387.45 4609142.391 4257869.26 4809819.994 5295513.376 11752009.34 8562584.732 5743256.244 4898299.296 4573258.229 4543357.853 4059360.449 7269891.52 4502150.289 5646244.306 7074513.821 3849950.835 6177958.399 8461686.53 4959081.918 3960703.833 4230644.162 3932654.123 4218463.226 10914047.66 7864223.233 9817879.63 6826772.719 4257852.318 4536536.115 8869749.4 6756807.689 7071676.208 5989154.686 6940341.785 10181824.73 2591325.439 4487319.837 5051379.464 3120296.697 6064131.805 11133766.82 2002585.35 3435700.139 3074291.147 3307331.93 3650861.456 2820427.43 1588747.234 2991321.515 3701601.568 2586949.884 3186063.934 3669269.818 1385524.532 2433237.795 1368034.415 2465191.039 1480033.568 7225435.301 2429581.249 2227637.298 2110315.527 2594637.321 2400315.091 3418449.425 3751445.157 7292132.767 3949430.789 5787408.957 8319875.062 1649528.247 3322756.638 5037163.38 6105923 3106445.571 3601369.125 3416386.753 815512.0368 1761698.661 1905814.71 1608132.44 2407143.227 taurine 3217036812 3051465843 3010470616 2798123903 2967420669 2943394718 1824318727 1894741619 1954126659 1995495379 1999788184 1900221691 1722704302 1708748589 1652200223 1607928352 1766056724 1716561617 3407158085 3175236751 3117944761 3258636088 3271447018 3158856258 3570283634 3222087019 3486394592 3524417810 3502892824 3507835460 2098353103 2257132215 2037639754 1958478738 1805133879 2025766566 1741965648 1692935821 1807776498 1746392650 1629220479 1738715392 1466525836 1554774874 1477585631 1582291519 1631229818 1548208257 2914730936 2685663913 2869527181 2625963818 3311623302 3101319858 2851206689 2560493005 2846246047 2780997593 2827450533 2989067257 1797449531 1731099363 1707825086 1536614083 1559747441 1632210461 1174123469 1184263822 1213537543 1199675696 1043465848 1149146643 1022035007 979411120.8 1030927535 984439479.4 1041643003 986934702.3 2207230348 1900975551 1951765013 1813305280 2002840273 1962349903 2352058049 1904911373 2152429157 2142062891 2248134731 2104890245 14228275.28 11583022.87 8318975.504 11276112.98 10047892.18 9211727.353 10726400.09 7794470.616 8102433.353 6136226.687 8217162.433 7657230.649 1103170918 1131581296 1101178106 1035264678 1022682071 973848034.5 816219815.4 752045054.2 755374681.2 727786824.6 694377019.4 821811556.7 11227912.46 8713219.743 10544177.71 7243014.502 6224830.817 8857604.911 8049297.115 7006541.527 7045177.269 7359632.399 5142023.614 6144157.169 1715252.736 1364586.081 1019529.576 1889142.335 3391842.927 2110373.983 1734035.006 905513.7115 1325099.878 1500004.488 1328370.723 817753.8753 1605422.442 676477.1678 1122008.119 1226371.505 1016008.243 642180.7117 333351506.1 529917731.8 552285432.2 587529151.1 425695365.5 407814635.4 450670906.6 522589055.2 450874728.3 421114089.2 651669917.1 429308018.7 1934179.002 1499343.65 12687768.87 1074466.897 1693885.535 1032795.211 2233496.705 979901.4825 1220260.618 715695.1067 747449.4839 573072.5482 187823510.2 269895843.6 227266965.7 303694692 217453940 taurocholic acid 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6852669.996 5548343.082 3962794.739 2621957.198 2900437.326 2253231.246 3106324.713 1186701.25 742854.3448 1637889.866 471018.4453 118413.2653 1278394.979 894330.3986 1483200.041 654366.5311 1169436.904 1056871.012 1759261.295 1499125.367 523690.4891 735252.5385 543271.9478 936675.7335 5483905.081 2549401.17 1732039.406 2337008.152 1459259.113 738241.3102 4247731.024 5500208.916 2721271.039 4036093.498 3398706.306 5535840.288 3201880.834 2722391.59 2382934.71 2081847.534 2611870.242 1896920.929 2420513.28 4258143.997 3474146.976 2348000.727 2734845.717 3257012.655 3629956.692 2791135.898 3451054.222 1573752.63 1788308.327 2343522.369 2399858.089 2082755.712 2358480.661 999625.0797 1019019.106 1754282.175 4192186.942 4400612.797 1826796.893 3199916.182 1831100.999 2553337.974 2843643.574 2721256.364 2457477.228 2878783.922 1582054.143 859930.4151 6571137.472 3758442.36 2408874.332 1896042.175 1279328.811 494710.1841 2583405.648 1945638.687 2023849.615 1651616.496 505104.3748 377214.4354 4753732.884 8022300.437 5709185.511 2632734.775 3132512.415 2036581.367 4971450.376 5082110.769 4875858.202 1999518.428 2156787.758 1702603.831 2148363.083 2743869.905 1026045.137 1079642.036 760085.3959 944334.3151 2487130.893 1466782.413 1151798.618 495589.4269 395054.952 1164913.797 417913.6983 1808440.523 2288111.681 1272894.095 362226.0762 thymidine 489829.2547 771691.3244 745029.6814 553459.5051 333021.0982 245330.3854 347748.4938 818592.3155 803847.9024 393671.5754 469880.2178 293612.0815 1044897.821 1288194.581 1324930.961 850681.4019 481736.5196 256356.4692 502049.0681 1152617.814 1042476.789 541091.6101 230724.5732 145685.4746 587195.416 922054.3519 639017.4569 543055.4997 443872.091 594352.9267 134118.2233 383716.0979 335094.2696 229521.0193 108954.4993 74146.31161 182826.6307 615544.6194 605383.5222 256948.134 262570.3407 118468.2553 595107.0206 1145011.935 1068331.102 521506.9571 350001.4004 140091.3699 260981.205 614900.5694 534986.2552 226300.8772 89631.98479 72065.93816 238893.8453 431930.4999 467814.8337 283211.2731 244273.7294 399007.8034 700301.709 1163428.392 1088487.082 766786.1333 275858.8786 163743.8181 691065.6681 1378815.8 1307330.239 508156.6676 620388.2647 260439.3236 1589040.259 2018201.588 2046116.835 944959.4136 494592.3472 308740.6616 976542.1322 1674559.28 1350300.883 563489.4506 199146.1932 199685.3167 964173.2632 827302.3519 1258961.501 483456.2546 250239.9563 628839.2301 196097.6159 332386.3591 263980.8642 350984.422 261010.7686 67545.22707 175651.8262 243512.9173 287011.3806 169660.4801 114236.8366 105790.2903 234604.9989 464231.8628 382295.1178 191423.1094 148680.565 134725.2307 618796.4461 518792.6677 525542.1067 431970.5538 193462.8789 144876.8309 227181.8754 348343.1318 324908.7654 125916.1595 62759.13414 68154.47571 240953.556 307384.7116 261803.8657 151193.308 152039.9607 157768.1998 528995.3076 66470.20635 0 228806.3113 198901.6171 324959.3984 607500.0015 349788.9322 231842.7707 371729.776 364586.8561 299182.9239 360952.0546 179928.3357 224707.9547 265369.7233 170786.93 210303.2462 120048.3042 122218.0673 102014.0121 158311.4725 229196.7174 193875.5113 181269.8028 168231.2518 131055.9166 236819.5316 291183.4505 212799.1002 352032.1871 159740.9716 177083.035 185050.4038 106595.6453 190543.6971 292752.9795 201873.442 225331.0399 216765.5786 120763.6759 192666.1122 307461.0761 207998.0454 140981.8038 165994.2879 325731.5581 thymine 2135112.071 3421524.155 3143815.172 2327688.11 1444869.781 1067362.871 1056459.272 2683782.603 2642588.864 1308933.17 1625933.825 915450.1107 2985901.242 3606536.025 3835317.863 2381511.158 1349351.329 762595.4878 1900942.526 4497255.45 4407318.905 2030580.372 1018008.771 608485.8226 2388127.257 3882609.028 2600545.984 2257865.372 2038027.67 2702390.65 498842.0388 1517996.22 1243589.926 882206.0791 464293.2726 321316.4082 632934.3147 1885562.491 1845378.532 749065.4654 863529.9399 462469.4875 1535989.194 2822646.837 2744160.226 1337676.013 877801.8057 407611.8884 963753.8891 2408792.934 1968054.793 876907.0177 438029.3129 294286.1293 990815.0938 1684175.267 1764365.089 1135038.319 990300.246 1766617.966 2881051.406 4988509.892 4678618.904 3202374.295 1248738.531 806612.3644 2243510.016 4427911.156 4184940.622 1548485.518 1987112.523 717193.2584 4365136.043 5702977.443 5820822.072 2640230.918 1418729.631 944972.9945 3635060.415 6351330.236 5432377.318 2234650.862 846508.9512 790492.7635 3751353.831 3514602.135 5066813.724 1786902.19 1114806.64 2801461.403 614830.4349 926080.7528 782833.1247 1046498.233 828975.4399 516073.3129 693526.7755 990103.1354 1146111.949 690230.8104 536880.3968 451600.4666 668976.7182 1378748.058 1310081.115 634214.6275 578258.0685 445629.6854 1531968.99 1356874.666 1349524.312 1052536.256 560570.1193 410417.3203 800355.1823 1449178.002 1367005.069 543135.3848 261743.3879 298003.8951 852542.8703 1145206.009 1003343.467 631425.1619 729176.3694 1160835.216 1078380.365 348084.6909 293965.2612 451602.8173 598876.545 741272.5133 1549030.615 744337.6626 485020.5933 811151.6581 843053.834 798029.063 1203807.883 532006.0071 640040.5754 937970.1195 754123.0534 568401.5984 340189.1093 332642.5942 313021.251 477844.3236 677958.4883 522461.545 412224.8934 340188.1884 289642.891 469271.473 633387.1538 467474.0296 1185885.264 576690.8479 714555.8351 574177.6979 397106.4022 646339.2665 1005490.287 561819.4931 663735.4801 729788.0101 626959.4004 581753.6888 701791.6583 611944.8228 512954.4121 647332.9422 576073.3605 trifluoromethanesulfonate 955544.5648 1175965.972 1156520.581 2351552.922 1619668.525 1174809.814 1080653.002 1095379.384 1142020.919 954053.6339 927269.6915 921447.7338 14932907.74 6872665.96 1155922.781 1633212.029 1661192.354 1157315.912 1561700.795 1385930.481 1226349.668 1347925.173 1222672.864 1165305.019 1464454.933 1683555.994 1303761.21 1187507.7 1139342.975 1628616.403 9692266.632 12927732.5 10752250.16 11187912.94 12052779.83 12219535.86 12137090.48 13653190.01 19158708.45 11573689.03 12588859.18 13074369.5 11654955.44 13038102.23 14028382.51 15238041.17 16211716.89 14588010.55 20352297.38 16479869.44 20993652.26 18546961.69 23804052.97 25469635.84 14596456.08 14164700.2 19143877 17057609.17 20488708.96 13923376.27 1690813.687 1633892.332 1704188.046 1721267.168 1545828.617 1730749.223 1106327.314 1703678.9 1207073.336 1049035.486 1128749.243 1168274.257 4300420.766 1839156.589 1580293.571 1676082 2840838.329 5096672.342 1812022.908 1646971.307 3677301.272 2217361.282 2061154.52 2786682.711 3711951.841 1367020.199 1697087.895 1765282.088 2192412.09 2020893.842 570905.3164 883442.8225 943372.2394 723867.3327 767428.9587 861562.6671 358141.1931 519746.7398 695980.6636 739324.92 543514.0129 429819.7956 862892.357 974876.8571 536416.9667 673265.5488 359676.0402 539463.6188 2665992.42 47139817.78 26320831.11 11147483.41 3472868.848 36531706.31 655533.6838 514821.4374 382133.8269 580715.5181 731690.7018 718750.9789 369813.666 1468517.642 439749.6121 487386.474 781550.4432 816265.1032 56568491.49 43307676.44 39050898.98 50434755.29 42323031.13 40879738.24 49537480.94 44604195.13 37220591.65 48247359.45 46407429.72 38789504.32 45915984.25 36283896.5 41984588.15 44205409.23 42897824.47 45508083.56 31591922.69 27696679.72 29369142.72 36088679.56 33863741.96 27650160.56 43671132.24 45522217.68 57067361.67 43817954.75 46394016.18 42281753.02 46519997.83 39520848.29 42114497.78 35992029.31 34080486.01 41755560.42 23282245.3 25728693.95 32133203.42 28017955.04 29111948.12 32676536.44 46193764.94 56697219.61 53053163.9 60555631.53 52838807.69 tryptophan 36751271.47 29661997.02 27255708.92 24066099.32 30812861.2 31011127.6 18740885.57 19856798.14 15729318.03 13838600.51 21369974.15 19041751.18 21131298.22 21025630.62 20156080.61 16319076.15 15804814.86 16495149.26 48684154.93 43220519.59 47778762.07 43043405.07 43824902.89 33142872.3 40115803.77 37322531.3 39131292.33 38300413.65 44458792.17 55950093.72 20290430.91 21177223.83 14541705.23 11070698.19 12640876.32 14154091.69 20621369.13 19008206.87 13729173.07 11429647.84 15249172.02 12961192.52 18415390.15 19706851.97 19460480.89 11655814.94 15541183.92 13041048.37 38802269.71 43843695.36 41366954.25 23289371.79 33269633.87 23793650.45 27982151.48 29440833.14 25152217.8 22657602.5 26448056.88 34579901.04 35711870.62 32117543.46 23934110.06 19484150.44 19273820.85 23109171.22 22328202.45 23851189.83 14558897.61 12434343.67 17818797.83 16774026.35 22480295.07 20720358.51 19404172.22 12103102.82 14449104.48 14794775.12 48998106.24 57889272.33 51871987.23 32854599.06 38485452.78 28297075.42 40519740.46 39555542.6 32316053.21 27622844.02 35736993.94 41732687.27 28874152.98 20393809.76 18422603.82 20930753.49 17960048.62 17829765.95 27805327.92 26999819.08 19658392.26 18958935.77 21171751.12 19285886.98 22872210.5 24878723.36 16277666.83 13789829.32 18729178.43 17075819.81 24978920.22 19628109.25 17811707.03 11726213.91 13334358.66 12827132.36 34413172.6 38282350.19 36022248.16 23743130.21 15949738.54 19986065.4 32225006.16 33368412.28 29690009.33 24468444.19 30606562.18 38820053.53 35001814.24 16376204.89 15497474.45 14751617.29 12635281.09 14594677.09 31537234.86 27414506.32 17947680.65 22134883.24 17444916.89 16865862.53 38249521.05 27068610.26 22762194 23105126.84 19574639.91 16961445.97 24560070.4 24643272.47 15702978.18 19613468.93 16449474.38 13770674.9 27719356.68 15605400.43 15098024.04 15101084.27 16047160.24 11818692.83 46226477.8 24044485.72 20147506.01 17475281.75 12482311 18657091.28 33847000.58 26085607.98 20013805.54 14500033.26 14445437.48 16674160.8 24931991.06 15473025.5 15361616.33 11836813.8 8325764.989 tyrosine 26890649.63 29337369.21 34032938.78 34665297.78 45061357.89 41679229.37 17627321.1 29825634.3 24888680.75 19278416.2 31119679.87 31895587.66 13479215.7 21633974.08 23798734.83 17345908.26 19136311.07 23046655.37 37106268.41 44860639.07 54249735.23 54624550.01 58050780.74 33035876.2 23196265.84 41667594.86 44003926.54 50479803.61 60622605.18 84420747.71 16446763.47 23342597.07 20093297.51 17349615.65 19710764.56 20862735.67 23987932.6 34158286.98 24393569.44 16217414.76 23785839.43 24083365.77 20117877.02 25693077.24 24763022.81 14896654.12 20391824.63 21473243.64 32174013.26 49023181.45 48870506.29 28522236.05 41475571.72 24008859.68 18083815.78 32674423.21 27461886.06 27287597.83 35135676.01 48204600.47 28588876.67 36241213.35 32052935.78 31266185.48 31927487.43 32837998.57 26299089.4 44173012.47 26416780.87 18029656.7 29171884.17 36547709.48 25554540.5 30652615.07 28888927.75 18015634.14 24338170.16 25265562.4 38644925.48 67602415.33 59153017.57 38949121.5 47498077.91 33310843.63 26546269.43 48811620.43 36713394.8 35442859.51 52357326.44 56861779.52 17301054.84 19588806.17 20448923.14 28302328.88 27669459.27 26992325.91 16516307.44 18744569.34 16239672.08 19927373.81 23451569.2 21653815.37 20030433.79 30634589.67 21401887.57 18688377.47 24724880.96 27707071.98 19340385.89 19355959.44 21879279.14 12608721.28 17818591.15 19090881.06 19069548.25 26656454.79 30317190.15 21694020.11 15821201.57 15570407.32 15103951.3 24711289.73 23539925.23 22353262.31 28517388.84 38794971.57 9828635.818 9762166.639 11889188.66 15340461.54 13837177.79 19332966.44 5303457.468 11963334.93 11425242.84 18249279.49 10633665.25 10067420.64 6401147.413 10954695.42 12665905.25 13317008.27 11967174.37 10588659.72 5510244.998 14503963.73 11515743.84 10125241.53 8023702.84 7216656.624 8049102.182 9712285.816 8608254.169 7244096.115 10959871.01 8461457.964 7985813.948 8570823.456 8400624.388 5968365.581 6333476.445 6098052.435 7859493.179 11294520.02 9968822.612 7208601.668 7275963.95 6193647.307 4847659.23 5887735.73 7705813.016 8674618.98 6384130.518 UDP 20465732.96 19655930.64 17309313.31 13719120.86 15233968.7 17406330.73 12520724.08 11851227.56 10762399.06 14446270.91 11413129.53 7500202.012 15054421.48 15103981.05 13316777.21 11165197.81 15707554.45 12350200.75 47786498.74 41757252.62 48074873.98 36803040.81 35270425.39 29125161.86 29816937.17 40876380.26 122197837.7 34064794.23 31220535 42971517.44 352175.4918 6037203.819 1481358.815 158060.1316 75864.24431 1507522.515 1783302.153 189667.6127 1440682.008 2576404.67 1449702.276 502420.8835 1973369.324 7609665.224 8775063.788 1623806.847 6743076.572 2038069.867 982430.3196 1481227.213 5108996.299 7788713.796 9868918.428 13707660.98 979955.456 1024108.597 4006360.705 8205072.877 2927602.306 9754847.835 31822392.96 26750028 27810498 20674671.57 12852235.46 23182614.2 27012187.94 14431262.29 13154440.75 15427514.05 6834782.7 3248578.504 32087732.06 20343761.37 16243968.45 17272793.47 11167210.45 7041297.448 41555037.03 25115538.46 20950855.97 31095691.99 35031778.25 28535326.25 42398061.99 27357209.87 43377319.21 46037067.08 37476683.29 21001292.15 4727947.69 5136197.93 2972538.052 2662043.195 4051813.676 2031439.109 4200824.134 5323668.527 4084680.569 3430580.338 2998470.624 2364894.536 7056755.456 8272124.117 9869429.568 10540886.48 5242156.084 5520220.211 13926891.36 9138057.827 8700882.532 3853857.535 6806868.591 4857418.966 11510800.53 8078872.56 7695755.209 7837052.403 4459581.696 5854033.353 13420090.34 14746884.23 10686910.94 8678380.262 6266219.262 4312711.391 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 UDP-glucuronic acid 6134360.402 4673367.172 4972466.633 2750216.233 1544800.534 1775183.377 5422041.876 4243775.258 3665176.383 3155352.068 1336964.873 828066.8881 5099580.133 4472514.865 3248206.71 2360154.062 1898008.284 1026589.827 8740881.404 7253657.269 5817206.392 4200864.095 3601475.268 4881054.604 10961659.32 6894838.855 6496153.78 6356437.609 5270227.148 3888479.758 2583893.019 2864564.286 2598075.448 1122485.319 449951.6683 2454573.366 3307885.791 1139665.129 1853532.299 3624193.923 1909179.493 1339839.082 2453035.608 3302499.83 2841196.364 1466109.299 3118531.557 2306595.93 6752305.34 3205165.671 4662149.931 3423403.618 7021581.687 7948586.648 6469960.11 3504325.023 4131024.579 4554689.539 3486989.654 3322180.016 2294799.715 898375.9457 1370549.266 805024.8373 450148.0709 990921.2584 1602030.21 1369972.535 1711671.639 2615668.219 439856.4935 267631.4094 2460895.919 752909.9951 715742.3605 2199607.555 757372.3866 263030.2256 3991614.679 1199915.587 875330.7075 4452247.372 3599920.984 2910958.829 4635353.659 1092972.081 2428060.71 4812736.141 2036589.902 1396839.349 873757.627 974816.7837 494625.8501 364403.074 791262.7977 307232.7478 1445664.498 965070.0008 1448525.713 916611.7117 691150.0363 338556.074 1084624.456 1929190.124 2709647.131 2317563.148 793397.2184 1148101.366 1091661.666 1123607.771 773496.1451 529988.8029 943917.8387 609189.7485 2105645.177 811561.793 1028455.463 1362334.965 911972.8289 928838.6987 2001510.007 1291863.266 1542966.374 1095959.827 1182473.28 1046018.583 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 UDP-N-acetylglucosamine 82221038.16 75572260.04 75941001.43 62565821.27 61166342.42 56981201.91 148619384.3 162977591.7 148246636.1 127703301.5 138414501.1 137046359.9 211362917.7 197117870.7 193373942 183751791.7 179990992.4 175737808.2 92810107.81 64193500.56 63022964.73 60419344.2 57931539.55 57322201.8 116688568.5 84090299.79 97828577.93 96315200.96 95682879.9 90176054.41 32794242.6 38686228.67 36620889.25 28376911.13 25570701.28 30301153.12 93987878.77 93005763.34 112419919.4 96116311.83 86137641.31 86107977.96 135894372 153079814.2 137636102.7 139414608.1 139830840.9 120144742.2 64993603.72 38002117.42 47671915.46 38643492.96 59151211.23 45318839.41 65149211.33 51972896.34 58538825.36 57980040.03 63469416.47 63852856.53 79872243.37 62410064.93 56187073.48 47657839.18 39048775.17 51297943.85 176237706.7 155130227.9 119718646.2 131592105.1 94769415.47 63352663.66 212504470.7 181318618.1 187383496.8 164329015.5 143630644.7 120613875.4 89302057.57 59121987.55 55460887.35 44854282.16 45612443.57 41932125.93 124174398.8 77177041.2 89166500.75 77031067.83 72904337.23 63678391.75 6154739.781 4611180.638 4323228.496 5270813.763 6228740.798 5725788.098 4545732.913 6632243.393 4707491.052 3565290.252 3785395.23 3147134.32 120655860.3 141168715.1 152734630.5 140977604 134002334.4 136451730.3 147466917.2 123432062.5 137324839 98841429.04 129036572 113312237 7548230.408 4873353.599 4393939.804 4936381.086 2670357.191 3182137.687 7133835.491 5120441.171 4858082.26 7187902.5 6902511.957 5309978.259 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 265859.2357 211737.5278 319259.9277 261951.9908 UMP 4402540.734 3350748.314 2817213.557 2353286.1 2123696.166 1842898.91 5367494.43 3642162.731 3532177.832 3801173.188 3249310.287 2376191.488 9522708.914 6898834.934 7190239.252 5977419.588 3047082.903 2789988.968 10972675.42 3533863.023 4883661.391 3117608.736 3188396.002 2149682.814 3717892.118 5992507.602 90599189.31 3235150.896 3199536.99 6413478.023 4994532.45 4088715.435 5056802.35 3463808.919 5079977.969 3765411.753 13460361.75 16044217.82 13996907.66 5059146.376 4532141.753 5421288.102 17629074.05 12676869.16 10492072.7 17149937.21 7517853.793 5828390.81 9446122.724 65725877.72 3784025.245 2714005.354 5348769.385 4114640.423 6173044.777 4542103.595 7369173.225 5086632.383 4318001.023 3373793.664 30558744.7 19207544.41 22018318.35 13569672.49 10178577.13 14612444.35 23782558.16 5210644.974 7548510.551 12760528 6603594.535 2828513.023 34043141.57 15466326.48 13084274.75 14250839.21 11425966.1 10330451.16 16451663.24 8513313.386 8498671.387 8911066.402 8878955.278 7767115.898 19735611.95 11363467.49 13915377.91 13563931.52 9059107.36 9509054.751 1069629.147 872991.5748 631646.0094 637350.2289 667194.4247 1046887.435 5596429.656 4936717.53 3844351.086 4335098.371 3188120.122 3257406.905 17199729.18 8979449.219 11238952.62 14622043.27 7692825.472 5220421.633 27418327.73 12324970.47 10106794.19 9178139.719 11986546.47 6384764.455 1107998.072 1110524.355 1830632.534 1193192.216 725901.7046 959268.686 927713.1137 2180732.236 2267018.982 1895261.176 2034803.533 933892.9375 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 215060.9 120628.305 207651.6224 30868.90062 uracil 2197290.753 2264398.755 2299406.819 2996108.599 4442903.729 4294205.3 999738.5699 2112273.917 1616748.188 1592414.746 5420806.742 4217248.434 2127928.175 1847911.607 2712151.933 1960144.567 2700478.433 3637726.87 2193095.126 5476641.142 6226070.352 5876699.887 5345881.994 3474139.248 2312867.904 3457651.086 5987674.108 4550064.98 9207220.864 15007514.24 989674.0026 1479204.323 1379100.114 1622746.929 2344151.193 2458674.713 874823.2356 2134098.872 1861743.957 1613820.895 4856269.93 3027473.448 3427527.815 1846523.611 2013890.732 2022162.961 2268706.583 2602222.874 2115674.252 8322556.458 5745636.927 2973543.022 3638312.511 2230417.83 1708207.236 2337356.343 3571778.198 2872291.509 5934173.203 10758448.49 2132875.558 2273722.662 1718835.096 1975313.096 2220740.742 2970382.753 930493.7855 1291267.079 1036466.173 955988.8306 3982300.162 2620296.414 2450906.858 1849839.949 1907630.475 1336041.923 1400685.731 2041041.993 2742059.618 6252021.56 6615234.385 2772736.54 3265717.171 1871816.933 2494009.771 2229475.813 3785359.395 2991329.121 7685235.124 13273696.08 6736913.388 4463458.721 3371525.478 4367119.514 6713624.446 9430973.264 7919950.166 5796521.203 4730434.738 4406359.248 4815561.502 5033115.297 6926623.091 3448583.743 2754888.061 3893798.868 5109967.962 4702751.578 7695868.109 3861978.359 5141467.183 2521511.688 3924417.871 4936059.836 6211797.098 9726863.796 9174663.067 6518761.12 3161611.68 4480632.2 4758462.78 5647953.072 6167714.593 5201655.194 8819374.691 12230798.49 1544719.528 1680582.906 1315733.561 1601337.858 3023623.6 7999912.841 2087308.813 2775281.944 1831386.709 2888078.636 3150969.98 2965275.303 1892081.102 1399630.193 1286296.214 1082407.303 1695619.388 1822250.222 960940.2187 1030779.883 779859.1061 1383511.65 1396990.285 1092362.901 2505282.221 1064417.557 904914.0904 1397089.122 2340043.319 1357103.162 2226152.029 2575717.865 1399266.616 1250823.056 5011186.383 989685.7929 3492711.323 2653865.282 3343262.011 988810.6117 1987725.279 1739813.118 536399.9032 677903.0345 717088.0805 701166.6743 664587.2782 uric acid 1015884.674 403283.8533 715498.2458 1325516.105 1193520.572 914039.7513 8069944.643 13009707.21 12792995.96 9878026.747 19805642.22 21594582.09 11392932.31 10968380.3 12907968.2 15805193.18 10224404.75 14350289.46 223161.5497 53811.45248 287229.851 239558.6992 360914.4581 527156.8117 374624.0223 37738.16883 207002.9528 651006.1034 887468.9576 323885.1243 2246760.092 2284053.06 3176861.465 4523251.324 6099429.349 9219860.842 9378809.742 15281220.5 15011416.25 18871857.86 44367078.72 31165537.44 335828.0877 2965037.205 20678300.62 7230216.061 21727913.72 11355012.54 1134634.137 649509.5521 336070.9447 530159.4207 1069363.102 2071666.617 1679040.505 417591.4562 774560.5533 2822934.141 2694622.582 748731.6782 12867820.61 3963371.416 3658827.94 5491844.265 4585597.801 7949867.955 27362414.32 37357171.81 33196695.64 30865350.83 70366009.27 62522455.41 43145989.31 37514969.31 43757503.99 37358339.69 27337573.08 46593094.56 16453190.69 24655858.53 21678202.31 14240811.65 21283137.43 9426365.671 17072248.26 5498717.237 11098853.23 8650143.662 17877167.32 30056113.58 1444752.607 143254.9564 260039.4119 348862.2887 683635.448 1028822.895 1528644.238 214046.3089 820624.513 1365192.889 842371.5623 317572.2005 80896373 57960675.74 69911511.73 77133486.67 106254258.6 111312239.8 101213183.6 75547434.28 83659353.29 56982573.91 73807526.4 84974421.44 1916072.75 1562095.066 2589872.516 1049847.243 881895.7409 2285204.123 1194063.479 0 1017642.984 1599758.736 2216735.001 2521911.7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3912236.538 8139890.616 10660540.61 22853760.7 12181251.56 uridine 269058.1482 470595.0159 742059.6489 784356.4759 991977.282 860939.6419 257902.4818 1071634.839 878784.7293 1092608.332 1759826.561 991424.9308 1508337.519 835774.7296 1431542.758 1292468.243 1836970.44 1821560.219 914906.0171 1735043.238 2110961.042 971401.4308 1040290.562 745723.5763 207461.8684 849847.647 1896849.869 990721.2897 1310310.957 1545093.259 253384.1438 237094.6854 276295.9438 245883.7588 280422.7644 264933.4308 542101.6715 312746.4212 338086.5973 386807.5913 476912.4564 280323.9803 1680483.94 410299.1754 421452.8396 471056.7576 614594.2036 445002.5892 794478.8802 2827722.713 1117284.864 246870.2452 419669.4813 295202.197 345926.7207 348536.8636 350050.4796 314806.2133 402689.2505 720635.3266 2132051.1 715384.5924 789026.0664 819826.7295 780433.9906 925222.1397 1491324.674 292295.5801 507223.427 2390511.052 1938031.076 630834.0891 5596235.528 1072660.833 1273500.485 1331399.977 1320838.625 1713095.407 4925082.303 2314853.334 3180920.474 1013206.729 1322733.167 309470.5274 1858041.124 838263.9692 672940.8285 818592.9774 479387.1182 1831769.065 2086013.82 1039175.233 684282.4531 815668.4418 1161606.107 1688870.989 2429160.178 1305833.731 1108236.166 762668.5872 813226.5431 628753.9364 2844341.377 940530.6117 916885.3553 1183580.623 912875.8772 892358.4086 3340939.497 1748289.371 2467520.058 1360114.854 1595778.054 1803693.016 1483320.905 1357061.966 1144921.826 817819.0458 388269.3479 522634.4202 1100124.974 1231687.064 1160543.863 785687.4107 937711.6585 788641.497 468851.1903 68169.70732 159734.8145 64989.54076 0 0 195777.5189 0 107880.0676 120927.5293 0 0 136109.5428 0 110190.5505 167227.9044 0 0 115902.6322 81308.72077 126563.0739 203236.2909 187773.597 195273.2019 256376.8566 149556.7573 218446.4643 227813.7043 218809.3323 252916.9028 282301.9954 0 250964.81 324426.5802 0 256308.9805 168359.8401 37403.01429 113675.9422 251427.5804 0 0 229753.6105 115026.6314 116258.0652 64405.48744 137835.8679 UTP 69454641.72 76222705.49 81342011.89 54750021.33 38671858.03 39946871.35 22540176.39 20981335.25 18818131.38 17692570.3 8319797.227 7133334.547 17163503.03 22832075.64 18395027.22 16656544.96 13729273.49 10351730.03 74800563.9 86992070.42 81975611.21 79063632.08 74460591.79 88913048.05 100131698.5 90460401.19 49573068.94 107900624 97819283.31 58400762.46 1583023.097 9985951.157 3977718.688 579636.9269 121450.5289 2612421.527 4067184.603 306052.5318 1742622.382 6277094.392 2729509.718 837557.1055 2761646.003 11442518.76 11218004.5 2312786.841 7667997.436 2291170.732 3549886.481 612756.5022 10554520.72 13654642.48 13904140.5 22244196.06 4560434.091 4151854.311 6315729.976 10534002.01 5551601.754 8983530.515 19535143.95 16200469.61 15013775.93 10799309.85 6945268.486 10001089.65 17842073.75 14296453.4 7634253.903 7675193.29 1905265.614 1297763.624 7907765.295 9174836.183 6451043.409 8207240.988 3000126.127 1579678.57 25523562.12 11748814.63 8610472.729 24304656.33 20937820.48 23323315.6 40411666.13 24030977.43 38451926.76 32477978.49 27247859.57 8479656.335 6200070.584 7122598.714 4770311.787 3718286.176 4315397.24 1499481.492 1866584.384 1840049.404 1720246.207 1195513.398 919189.8363 561500.4236 6310338.64 11755823.46 12773396.65 8895980.196 4611409.503 5330526.108 4273079.367 8574537.498 8784119.394 3636019.13 4615820.47 3192471.851 9941804.713 3250760.549 3353443.999 3517740.577 2401473.515 3014356.764 11868356.27 5223418.261 4016250.575 3288482.46 2345741.488 2471984.186 169571.7988 225764.1421 195389.0109 601593.8505 297334.4564 247738.6597 318330.961 343568.1035 290844.3929 341542.2994 467086.0882 190012.1904 341607.8045 260344.2166 315442.7396 312373.1578 157863.9263 27585.57818 0 0 0 0 61283.74045 0 0 0 15219.76832 40835.28864 43018.6481 0 104607.8103 191600.0104 172875.2769 178976.5924 121609.7531 272673.7113 201950.1546 202068.9667 207338.6455 176911.5851 126974.3865 131378.7399 76556.30345 74256.86985 112388.9544 95920.17839 66740.81928 valeric acid isomers 4864000.426 4776702.559 5446735.368 4755919.486 5584981.867 4518648.787 579166.7271 541835.6123 557662.8987 488780.9237 430006.0405 639381.035 612622.8202 787128.7386 694325.0278 869115.2356 628633.7218 762067.7586 858185.7495 1286237.124 762220.9887 1171101.402 562346.4716 595992.9825 3236634.639 1981003.952 3286415.761 2690413.507 747034.881 2186741.072 11424841.45 9000904.576 31456139.9 32298070.17 8794704.143 22326119.58 2450543.94 2660954.756 3430860.475 2621713.086 2229167.266 2816801.827 2766915.073 2704700.669 2467109.703 2848836.974 2615638.625 3789259.912 40706030.46 21074777.36 11607551.68 23472366.5 35171208.59 30211688.21 5148750.172 6254354.399 29873110.07 30433164.7 38002570.35 17175976.35 1707855.936 2284472.503 3447824.198 2978093.331 1444901.69 5054354.03 533767.8838 580239.2329 397739.9235 451843.9024 527533.6551 371478.0957 832573.4401 620490.4216 694123.3559 676635.5762 595172.5007 786917.6107 4961618.18 3546105.547 4253817.371 2812164.75 2924040.182 822565.7679 4093458.624 1760845.172 2214185.669 1599236.708 2938191.953 4955014.819 2931354.733 1418746.703 4028975.067 3188179.065 2581523.574 1428289.266 2301682.113 1240863.3 2926095.729 3171105.481 554845.8546 1811827.387 523532.1871 403483.1727 400233.3787 555822.6783 326770.3294 551379.156 595650.7012 598047.4315 469636.4239 613041.9054 367036.7525 396453.7198 627203.739 733656.3314 665825.7242 1332303.831 567333.9485 637584.6314 886297.8251 2022171.053 2805628.49 969301.2546 1423388.087 769390.1122 44942067.42 61438608.55 26798752.47 44380518.78 14757998.26 30004260.41 23237327.46 60380720.92 48776829.13 60413401.57 75361274.99 21216430.29 16501195.37 53507206.58 38646453.92 10851820.98 18008386.46 20672982.17 2174192.688 2499251.816 2332574.023 2392079.466 2927629.945 2283484.936 2323848.339 3108832 3230058.411 3681415.331 3872741.807 3274377.062 28071912.3 56391915.01 34840312.4 8364228.55 9838357.134 30246886.11 60827243.28 28739878.13 14653853.05 18870837.77 37413278.19 19102436.66 7215141.968 8641665.261 6584136.452 6378062.157 33631391.2 xanthine 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 38709428.37 16900832.57 12249289.76 16681470.34 31418404.31 41698180.91 49559196.59 30247810.98 29314998.87 23775648.02 23757391.61 26002034.44 34332546.59 6822043.549 10573453.16 16784401 14995695.55 18946795.5 34848835.21 19051039.91 31662080.55 16174387.26 22603257.89 30447630.43 22164245.4 26955470.56 18219772.34 22452618.76 11192261.44 18690050.13 16568545.12 20006799.23 20432615.5 17459251.93 22616676.82 37080618.22 36939275.61 6468324.095 6476943.536 2165870.384 16465338.32 26998838.02 12847290.67 0 560693.4717 5719790.73 5751994.951 12211583.59 156847.2754 0 48861.18122 444938.0396 1622460.646 4235806.39 26832469.25 24624563.37 19848303.45 25185084.83 13593863.33 3553616.842 38464881.76 16948654.31 23189694.71 22083393.54 30056948.15 6675162.467 72480159.16 18378823.93 11375180.74 11359393.78 24882797.66 19347611.52 44438873.18 16761936.22 12615655.71 2527197.264 14272733.31 8979496.301 227557.1568 302758.046 722826.0942 553698.3353 2801156.65 xylonic acid 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2463575.815 1431837.459 1597281.051 2019899.351 2518327.396 2584164.697 2404400.285 1428348.736 1352659.165 1438834.702 2061455.3 2208594.516 2124754.564 4952070.496 2723198.921 2458594.713 1998817.65 2207897.107 3306516.056 2732630.666 2648857.056 2261433.619 2209578.903 2684943.863 2538656.126 1872671.565 2031298.728 2280543.763 2133733.272 3407194.148 3087337.023 1569584.853 1865309.856 2019702.939 2453514.841 2705712.652 2870128.344 3381105.373 3499625.21 4931870.032 6415538.753 7372749.766 2072953.606 2115547.157 2450859.567 4081070.565 4498790.284 5118002.829 2208521.906 2165634.869 2690377.841 2892557.368 4505900.805 7622073.52 988301.2765 2403632.38 2938260.633 2761264.709 2998623.278 3679719.065 1135152.495 1923147.127 1949030.736 1735825.72 2871105.464 2776087.817 5108005.517 3756760.261 6762836.495 4454879.348 9644160.226 11604849.52 4464002.517 3718337.128 4468363.551 3988645.166 5584090.021 7603107.053 539877.9988 1308423.836 2432003.014 4080117.423 6516732.155 xylulose 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 286481.5821 375141.8383 380565.2762 307551.7532 362360.6788 475025.2877 325152.613 337467.8497 300548.9972 312977.4982 369458.5373 398989.3189 283510.274 332078.5892 328127.6724 262973.3463 345267.2042 354795.5893 532800.8387 359256.7159 637255.4807 870779.3407 824554.3867 904330.4109 602275.0248 515605.8908 696189.9439 622407.4736 833268.041 831580.3063 327926.3484 366733.4337 319055.388 326049.0922 327091.121 407819.4352 285282.4231 292905.2968 98557.97049 243241.6059 208289.9454 332791.887 478570.1401 533720.4418 215225.3417 419750.9345 422001.5402 384798.6577 564660.8171 513071.3378 482470.5476 510516.1836 513202.1294 701149.2688 666444.9252 680824.0385 759110.0503 714153.2748 842481.8461 660962.6982 113812.3253 508219.5058 457043.6854 631374.0928 513208.4888 548866.5507 247038.7077 442018.2956 304174.5732 433254.0324 422808.7016 445614.5011 77669.91038 692157.0676 630025.2466 259643.8206 709138.9244 331731.4902 356597.2124 696255.9124 562237.7869 447711.5349 337201.0926 755393.1336 369586.9981 393808.4109 431323.4314 608031.664 336266.7063 661704.4587 413369.4474 658810.6587 566242.5117 619044.2846 782769.7044 880023.2323 445762.6906 512772.2115 554989.5933 554835.2921 630458.5471 1001207.94 290979.3525 501772.1388 306883.5205 879781.3235 622266.1084 460525.2271 548583.8852 255805.4111 261999.5515 483623.4992 762832.0682 664894.2454 311047.2608 149408.9267 189764.556 221989.2857 218927.453 203973.7947 131904.4241 193841.7965 153044.0236 163343.6741 150154.9877 195454.9176 1145176.77 622419.6144 790936.1857 981123.0233 724878.1546 1320906.94 824819.3159 704289.6385 752616.1577 729541.4953 708114.5912 1042886.34 0 0 0 0 0 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name quantified m/z retention time, min PubChem ID 3-methyl-2-oxobutyrate 115.04 2.37 49 4-aminobutyrate 102.056 8.01 119 6-phosphogluconic acid 275.017 10.71 91493 acetyl-CoA 808.119 6.86 444493 adenylosuccinic acid 462.067 11.31 447145 ADP 426.022 8.8 6022 AICAR 337.059 8.04 90471726 alpha-ketoglutarate 145.014 8.9 51 AMP 346.056 7.6 6083 anthranilic acid 136.04 3.35 227 arachidic acid 311.296 1.68 10467 argininosuccinate 289.115 9.61 439998 ascorbate 175.025 7.39 54670067 aspartate 132.03 8.21 5960 ATP 505.988 9.83 5957 butyric acid 87.0452 2.97 264 caproic acid 115.076 2.16 8892 carbamoyl-aspartate 175.036 9.72 279 CDP 402.011 10.21 6132 CDP-ethanolamine 445.053 9.33 123727 cholic acid 407.28 2.12 221493 cis-aconitate 173.009 10.71 643757 citrate / isocitrate 191.02 10.71 311 CMP 322.045 8.8 6131 CoA 766.108 7.76 87642 CTP 481.977 11.2 6176 cysteine 120.012 8.71 5862 cystine 239.017 8.67 595 cytidine 242.078 5.37 6175 deoxycholic acid 391.285 2 222528 deoxyinosine 251.079 3.91 135398593 dihydroorotate 157.025 5.46 5461056 dihydroxyacetone-phosphate 168.991 8.75 668 dTMP 321.049 6.97 9700 dTTP 480.982 9.5 64968 erythrose-4-phosphate 199.001 9.76 122357 fructose 179.056 6.26 2723872 fructose-1;6-bisphosphate 338.989 11.03 10267 fructose-1-phosphate 259.022 8.64 65246 fructose-6-phosphate 259.022 9.17 69507 fumarate 115.004 9.23 444972 GAR 285.049 9.55 160913 GDP 442.017 10.82 135398619 glucose 179.056 7.02 5793 glucose-6-phosphate 259.022 9.89 5958 glutamate 146.046 8.01 33032 glutamine 145.062 7.44 5961 glyceraldehyde-3-phosphate 168.991 11.09 729 glycerol-3-phosphate 171.006 8.48 754 GMP 362.051 9.78 135398631 GSH 306.077 7.86 124886 GSSG 611.145 10.54 65359 GTP 521.983 11.83 135398633 guanosine 282.084 5.89 135398635 histidine 154.062 7.02 6274 hydroxyglutarate 147.03 8.7 43 hypotaurine 108.012 7.38 107812 IMP 347.04 8.96 135398640 lactate 89.024 4.23 612 lauric acid 199.17 1.77 3893 malate 133.014 9.28 525 myristic acid 227.202 1.72 11005 N-acetylglucosamine-phosphate 300.049 8.42 439219 N-acetylglutamate 188.056 7.86 70914 NADH 664.118 7.44 439153 NADPH 744.084 10.35 5884 oleic acid 281.249 1.68 445639 orotate 155.01 4.83 1492348 palmitic acid 255.233 1.68 985 phosphate 96.97 6.58 1004 phosphatidylethanolamine 298.07 8.8 5327011 phosphocreatine 210.029 8.7 9548602 phosphoenolpyruvate 166.975 10.43 1005 phosphoglycerate 184.986 9.94 439183 phosphorylethanolamine 140.012 8.9 1015 phosphoserine 184.002 9.61 68841 propionic acid 73.0295 3.91 1032 pyruvate 87.009 3.49 1060 quinolinic acid 166.015 3.86 1066 rib/ribul/xylul-ose-phosphate 229.012 8.63 439190 saccharopine 275.125 8.8 160556 S-adenosyl-homocysteine 383.114 6.47 439155 SAICAR 453.066 12.13 160666 sedoheptulose-7-phosphate 289.033 9.55 22833559 sorbitol 181.072 6.58 5780 stearic acid 283.264 1.68 5281 succinate 117.019 8.7 1110 taurine 124.007 7.28 1123 taurocholic acid 514.284 2.06 6675 thymidine 241.083 2.69 5789 thymine 125.036 2.69 1135 trifluoromethanesulfonate 148.953 1.95 2758875 tryptophan 203.083 5.04 6305 tyrosine 180.067 6 6057 UDP 402.995 9.78 6031 UDP-glucuronic acid 579.027 11.72 17473 UDP-N-acetylglucosamine 606.074 8.75 445675 UMP 323.029 8.64 6030 uracil 111.02 3.38 1174 uric acid 167.021 6.47 1175 uridine 243.062 4.07 6029 UTP 482.961 10.82 6133 valeric acid isomers 101.061 2.43 7991 xanthine 151.026 5.57 1188 xylonic acid 165.04 6.65 6602431 xylulose 149.046 4.93 5289590 METABOLITES_END #END