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MGP000032

UniProt Annotations

Entry Information
Gene Nameacid phosphatase 1, soluble
Protein EntryPPAC_HUMAN
UniProt IDP24666
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Comment=The ratio of isoform 1 to isoform 2 is 2:1 in allele A, 4:1 in allele B and 1:4 in allele C.; Name=1; Synonyms=F, A, Alpha, LMPTP-A, HCPTP-A; IsoId=P24666-1; Sequence=Displayed; Name=2; Synonyms=S, B, Beta, LMPTP-B, HCPTP-B; IsoId=P24666-2, P24667-1; Sequence=VSP_010087; Name=3; Synonyms=C, LMPTP-C; IsoId=P24666-3; Sequence=VSP_010088; Name=4; IsoId=P24666-4; Sequence=VSP_054074, VSP_054075; Note=No experimental confirmation available.;
Catalytic ActivityA phosphate monoester + H(2)O = an alcohol + phosphate.
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Enzyme RegulationInhibited by sulfhydryl reagents.
FunctionActs on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
InteractionSelf; NbExp=1; IntAct=EBI-717701, EBI-717701;
PolymorphismACP1 is genetically polymorphic. Three common alleles are known in Caucasians: ACP1*A, ACP1*B and ACP1*C. They give rise to six different phenotypes. Each allele appears to encode two electrophoretically different isozymes, F and S, which are produced in allele-specific ratios. The sequence shown is that of allele ACP1*B and allele ACP1*C.
SimilarityBelongs to the low molecular weight phosphotyrosine protein phosphatase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitIsoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1. {ECO:0000269|PubMed:11971983, ECO:0000269|PubMed:12167657, ECO:0000269|PubMed:9499402}.
Tissue SpecificityT-lymphocytes express only isoform 2. {ECO:0000269|PubMed:9038134}.
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