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MGP001789

UniProt Annotations

Entry Information
Gene Namelactalbumin, alpha-
Protein EntryLALBA_HUMAN
UniProt IDP00709
SpeciesHuman
Comments
Comment typeDescription
FunctionRegulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
SimilarityBelongs to the glycosyl hydrolase 22 family. {ECO:0000255|PROSITE-ProRule:PRU00680}.
Subcellular LocationSecreted.
SubunitLactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
Tissue SpecificityMammary gland specific. Secreted in milk.
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