MGP Database

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MGP003815

UniProt Annotations

Entry Information
Gene Namesolute carrier family 28 (concentrative nucleoside transporter), member 2
Protein EntryS28A2_HUMAN
UniProt IDO43868
SpeciesHuman
Comments
Comment typeDescription
Enzyme RegulationInhibited by formycin B.
FunctionSodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
SimilarityBelongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.
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