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MGP005717

Record overview

MGPD IDMGP005717
Gene ID60490
SpeciesHomo sapiens (Human)
Gene Namephosphopantothenoylcysteine decarboxylase
Gene Symbol PPCDC
SynonymscoaC; MDS018; PPC-DC;
Alternate namesphosphopantothenoylcysteine decarboxylase;
Chromosome15
Map Location15q24.2
EC Number4.1.1.36
SummaryBiosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for PPCDC

Proteins

phosphopantothenoylcysteine decarboxylase isoform a
Refseq ID:NP_068595
Protein GI:71725351
UniProt ID:Q96CD2
mRNA ID:NM_021823
Length:204
RefSeq Status:
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLV
APLDANTLGKVASGICDNLLTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSG
FQQS
 
phosphopantothenoylcysteine decarboxylase isoform b
Refseq ID:NP_001288030
Protein GI:666875837
UniProt ID:Q96CD2
mRNA ID:NM_001301101
Length:161
RefSeq Status:
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWETCVMRAWDRSKPLLFCPAMNTAM
WEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS
 
phosphopantothenoylcysteine decarboxylase isoform c
Refseq ID:NP_001288031
Protein GI:666875839
UniProt ID:Q96CD2
mRNA ID:NM_001301102
Length:172
RefSeq Status:
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLLTCVMRAWDRSKP
LLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS
 
phosphopantothenoylcysteine decarboxylase isoform d
Refseq ID:NP_001288032
Protein GI:666875806
UniProt ID:Q96CD2
mRNA ID:NM_001301103
Length:129
RefSeq Status:
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGD
EGLGAMAEVGTIVDKVKEVLFQHSGFQQS
 
phosphopantothenoylcysteine decarboxylase isoform e
Refseq ID:NP_001288034
Protein GI:666875818
UniProt ID:Q96CD2
mRNA ID:NM_001301105
Length:81
RefSeq Status:
MRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS
 
phosphopantothenoylcysteine decarboxylase isoform e
Refseq ID:NP_001288033
Protein GI:667477855
UniProt ID:Q96CD2
mRNA ID:NM_001301104
Length:81
RefSeq Status:
Protein sequence is identical to GI:666875818 (mRNA isoform)
 
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