MGP Database

MGP005794

Ontology/Pathway Information

Entrez Gene ID	64805
Gene Name	purinergic receptor P2Y, G-protein coupled, 12
Gene Symbol	P2RY12
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009925	IEA:Ensembl	C	basal plasma membrane
GO:0005901	IEA:Ensembl	C	caveola
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005887	IBA:GO_Central	C	integral component of plasma membrane
GO:0031224	IDA:UniProtKB	C	intrinsic component of membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0001621	IDA:UniProtKB	F	ADP receptor activity
GO:0001609	IEA:Ensembl	F	G-protein coupled adenosine receptor activity
GO:0005085	TAS:Reactome	F	guanyl-nucleotide exchange factor activity
GO:0007193	IMP:UniProtKB	P	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0070588	IEA:Ensembl	P	calcium ion transmembrane transport
GO:0030030	IEA:Ensembl	P	cell projection organization
GO:0035589	IDA:GOC	P	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0007186	IDA:UniProtKB	P	G-protein coupled receptor signaling pathway
GO:0007599	NAS:UniProtKB	P	hemostasis
GO:0045596	IEA:Ensembl	P	negative regulation of cell differentiation
GO:0010700	IEA:Ensembl	P	negative regulation of norepinephrine secretion
GO:0030168	TAS:Reactome	P	platelet activation
GO:0070527	IMP:UniProtKB	P	platelet aggregation
GO:0043547	TAS:GOC	P	positive regulation of GTPase activity
GO:0043270	IEA:Ensembl	P	positive regulation of ion transport
GO:0071805	IEA:Ensembl	P	potassium ion transmembrane transport
GO:0043491	IEA:Ensembl	P	protein kinase B signaling
GO:0051924	IEA:Ensembl	P	regulation of calcium ion transport

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_20653	ADP signalling through P2Y purinoceptor 12
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_19231	G alpha (i) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_604	Hemostasis
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_18342	Nucleotide-like (purinergic) receptors
REACT_18289	P2Y receptors
REACT_798	Platelet activation, signaling and aggregation
REACT_20524	Signal amplification
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction

SMP Pathway Links

SMP ID	Description
SMP00260	Clopidogrel Action Pathway
SMP00610	Clopidogrel Metabolism Pathway
SMP00261	Ticlopidine Action Pathway
SMP00611	Ticlopidine Metabolism Pathway