#METABOLOMICS WORKBENCH wpathmasiri_20140314_9698541_mwtab.txt DATATRACK_ID:71 TEXT OUTPUT STUDY_ID:ST000039 ANALYSIS_ID:AN000059 PROJECT_ID:PR000025 VERSION 1 CREATED_ON 10-02-2015 #PROJECT PR:PROJECT_TITLE Metabolomics Involved in Early Life Antibiotic Exposures PR:PROJECT_TYPE Obesity modeling of antibiotic exposure PR:PROJECT_SUMMARY The project Metabolomics Involved in Early Life Antibiotic Exposures profiled a PR:PROJECT_SUMMARY total of 90 samples from five sub-studies (DuraSTAT, TranSTAT, NOD, EstroSTAT PR:PROJECT_SUMMARY and VG STAT) which included a total of four sample matrices (urine, serum, liver PR:PROJECT_SUMMARY tissue and cecal contents). Within each sub-study, there were three sample PR:PROJECT_SUMMARY matrices except for VG STAT, for which there was only two. For each matrix type PR:PROJECT_SUMMARY within each sub-study 6 samples were analyzed for a total of 18 samples per PR:PROJECT_SUMMARY sub-study (9 of each in VG STAT), the samples were equally divided into PR:PROJECT_SUMMARY STAT/PAT-treated (sub-therapeutic antibiotic treatment (STAT) and therapeutic PR:PROJECT_SUMMARY dose-pulsed antibiotic treatment (PAT)) collected at various time-points versus PR:PROJECT_SUMMARY untreated Controls for each matrix. PR:INSTITUTE New York University PR:DEPARTMENT School of Medicine PR:LABORATORY Blaser Laboratory PR:LAST_NAME Blaser PR:FIRST_NAME Martin J. PR:ADDRESS 550 First Avenue, BCD 690, New York, NY 10016 PR:EMAIL Martin.Blaser@nyumc.org PR:PUBLICATIONS Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. PR:PUBLICATIONS Nature Reviews. Genetics 2012; 13; 260-270 PR:PHONE - #STUDY ST:STUDY_TITLE Metabolomics Involved in Early Life Antibiotic Exposures(VGSTAT-Liver) ST:STUDY_TYPE Metabolomics ST:STUDY_SUMMARY In the VG STAT sub-study, a total of 18 samples from 7 week old, male C57BL/6 ST:STUDY_SUMMARY mice; comprised of 9 cecal content samples and 9 liver tissue samples were ST:STUDY_SUMMARY analyzed. Three mice/matrix were given penicillin VK, 3 were given penicillin G, ST:STUDY_SUMMARY and 3 mice/matrix were non-treated Controls. The mice were housed with ST:STUDY_SUMMARY conventional bedding and fed a normal diet. ST:INSTITUTE RTI International ST:DEPARTMENT Systems and Translational Sciences (STS) ST:LABORATORY NIH Eastern Regional Comprehensive Metabolomics Resource Core (RTI RCMRC) ST:LAST_NAME Sumner ST:FIRST_NAME Susan ST:EMAIL ssumner@rti.org ST:NUM_GROUPS 2 ST:TOTAL_SUBJECTS 6 ST:STUDY_COMMENTS VG STAT_Liver Study ST:PHONE - ST:ADDRESS - #SUBJECT SU:SUBJECT_TYPE Animal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 SU:GENOTYPE_STRAIN C57BL/6 SU:AGE_OR_AGE_RANGE 7 weeks at collection SU:GENDER Male SU:ANIMAL_ANIMAL_SUPPLIER Jackson Labs SU:ANIMAL_HOUSING conventional bedding SU:ANIMAL_FEED normal diet SU:SPECIES_GROUP Mammal #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - LVC018 Treatment Group:Control SUBJECT_SAMPLE_FACTORS - LVC020 Treatment Group:Control SUBJECT_SAMPLE_FACTORS - LVC023 Treatment Group:Control SUBJECT_SAMPLE_FACTORS - LPL101 Treatment Group:Pool QC SUBJECT_SAMPLE_FACTORS - LPL102 Treatment Group:Pool QC SUBJECT_SAMPLE_FACTORS - LPL103 Treatment Group:Pool QC SUBJECT_SAMPLE_FACTORS - LPL201 Treatment Group:Pool QC SUBJECT_SAMPLE_FACTORS - LPL202 Treatment Group:Pool QC SUBJECT_SAMPLE_FACTORS - LPL203 Treatment Group:Pool QC SUBJECT_SAMPLE_FACTORS - LVG059 Treatment Group:STAT (pen G) SUBJECT_SAMPLE_FACTORS - LVG061 Treatment Group:STAT (pen G) SUBJECT_SAMPLE_FACTORS - LVG065 Treatment Group:STAT (pen G) SUBJECT_SAMPLE_FACTORS - LVV036 Treatment Group:STAT (pen V) SUBJECT_SAMPLE_FACTORS - LVV039 Treatment Group:STAT (pen V) SUBJECT_SAMPLE_FACTORS - LVV040 Treatment Group:STAT (pen V) #COLLECTION CO:SAMPLE_TYPE liver CO:COLLECTION_TIME 7 weeks CO:COLLECTION_SUMMARY - #TREATMENT TR:TREATMENT_SUMMARY Three mice were given penicillin VK, three were given penicillin G, and 3 mice TR:TREATMENT_SUMMARY matrix were non-treated controls. STAT = sub-therapeutic antibiotic treatment. TR:TREATMENT_COMPOUND Penicillin VK and Penicillin G #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Frozen liver samples were weighed (50-100 mg) into labeled homogenizer bead SP:SAMPLEPREP_SUMMARY tubes. Cold acetonitrile:water (50%) was added to tissue based on weight to SP:SAMPLEPREP_SUMMARY make 1 mg/mL homogenates. The samples were extracted and homogenized on a Spex SP:SAMPLEPREP_SUMMARY Geno/Grinder for two 45 second pulses at 1750 rpm. Samples were centrifuged at SP:SAMPLEPREP_SUMMARY 12000 rcf for 5 min. Liver supernatants were transferred into BSI-labeled SP:SAMPLEPREP_SUMMARY tubes. A 500 μL aliquot/sample was transferred into a second set of BSI-labeled SP:SAMPLEPREP_SUMMARY tubes for further processing. To make pooled samples, a 300 μL aliquot of SP:SAMPLEPREP_SUMMARY selected TranSTAT liver supernatants was combined in a 2 mL tube and used for QC SP:SAMPLEPREP_SUMMARY samples in DuraSTAT, TranSTAT, EstroSTAT and NOD sub-studies. Additionally, a SP:SAMPLEPREP_SUMMARY 200 μL aliquot of selected VG STAT liver supernatants was combined in a SP:SAMPLEPREP_SUMMARY separate 2 mL tube and used as QC samples in the VG STAT sub-study. Three 500 SP:SAMPLEPREP_SUMMARY μL aliquots were transferred into BSI-labeled tubes for each set of Pooled QC SP:SAMPLEPREP_SUMMARY samples. All samples were then dried on an Eppendorf rotaVap (V-AL setting) at SP:SAMPLEPREP_SUMMARY 30°C until dry and stored at -80 °C. On the second day of processing, 630 μL SP:SAMPLEPREP_SUMMARY of D2O was added into each dried liver extract tube. Chenomx Internal Standard SP:SAMPLEPREP_SUMMARY solution (Chenomx ISTD, Edmonton, Alberta, Canada) contains 5mM SP:SAMPLEPREP_SUMMARY 4,4-dimethyl-4-silapentane-1-sulfonic acid (DSS, Chemical Shift Indicator), 100 SP:SAMPLEPREP_SUMMARY mM Imidazole (pH indicator), and 0.2% NaN3 (to inhibit bacterial growth) was SP:SAMPLEPREP_SUMMARY added (70 µl), and the samples were vortexed on a multi-tube vortexer for 10 SP:SAMPLEPREP_SUMMARY minutes at speed 5. Tubes were then centrifuged at 12000 rcf for 5 minutes and a SP:SAMPLEPREP_SUMMARY 600 μL aliquot of the supernatant was transferred into 5mm NMR tubes (Wilmad SP:SAMPLEPREP_SUMMARY LabGlass, New Jersey, USA) which were kept on ice until data acquisition. SP:SAMPLEPREP_PROTOCOL_FILENAME VG_STAT_Liver_Metabolomics_Procedure.docx #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE - CH:INSTRUMENT_NAME - CH:COLUMN_NAME - #ANALYSIS AN:LABORATORY_NAME RTI/ DHHMRI AN:ANALYSIS_TYPE NMR AN:ACQUISITION_DATE 41527 AN:SOFTWARE_VERSION Top Spin 3.2 AN:OPERATOR_NAME Wimal Pathmasiri/ Kevin Knagge/ Jason Winnikie AN:DETECTOR_TYPE NMR AN:DATA_FORMAT NMR #NMR NM:INSTRUMENT_TYPE Bruker Avance III NM:NMR_EXPERIMENT_TYPE 1D 1H NM:FIELD_FREQUENCY_LOCK Deuterium NM:STANDARD_CONCENTRATION 0.5mM NM:SPECTROMETER_FREQUENCY 700 MHz NM:NMR_PROBE cyrogenically cooled ATMA inverse probe NM:NMR_SOLVENT D2O NM:NMR_TUBE_SIZE 5mm x 4inch NM:SHIMMING_METHOD topshim NM:PULSE_SEQUENCE noesypr1d NM:WATER_SUPPRESSION presat NM:PULSE_WIDTH 14.84 us NM:POWER_LEVEL 25.704w NM:RECEIVER_GAIN 10 NM:OFFSET_FREQUENCY 3293 Hz NM:CHEMICAL_SHIFT_REF_CPD DSS NM:TEMPERATURE 298.1 K NM:NUMBER_OF_SCANS 64 NM:DUMMY_SCANS 4 NM:ACQUISITION_TIME 2.3243434 NM:RELAXATION_DELAY 2 s NM:SPECTRAL_WIDTH 20.1358 NM:NUM_DATA_POINTS_ACQUIRED 65536 NM:REAL_DATA_POINTS 65536 NM:LINE_BROADENING 0.5 NM:ZERO_FILLING yes NM:APODIZATION lorentzian NM:BASELINE_CORRECTION_METHOD polynomial NM:CHEMICAL_SHIFT_REF_STD DSS NM:INSTRUMENT_NAME Bruker Avance III #NMR_BINNED_DATA NMR_BINNED_DATA:UNITS Peak area NMR_BINNED_DATA_START Bin range(ppm) LVC018 LVC020 LVC023 LPL101 LPL102 LPL103 LPL201 LPL202 LPL203 LVG059 LVG061 LVG065 LVV036 LVV039 LVV040 0.50...0.53 0.85425 0.01792 0.028597 0.034153 0.56855 0.018674 0 0.0090816 0.0027236 0.076931 0.0099767 0.035201 0.012026 0.94467 0.88688 0.53...0.56 1.0448 0 0 0 0.76051 0 0.00066786 0.0045578 0.0037642 0.00079527 0 0 0 1.2333 1.0994 0.56...0.58 0.79971 0 0 0 0.60116 0 0 0 0 0 0.0071966 0 0 0.93977 0.85179 0.58...0.60 0.82579 0.021074 0.030482 0.031629 0.65713 0.017371 0.017552 0 0 0.035237 0.075185 0 0.03913 0.95626 0.88686 0.60...0.65 5.6174 3.9218 4.397 4.2292 5.9805 4.3979 8.3337 8.9043 8.1398 5.3139 5.315 5.2915 4.6223 5.7644 5.7312 0.65...0.67 1.2205 0.34243 0.32541 0.31969 0.9292 0.29496 0 0 0.024871 0.47208 0.30719 0 0.17343 1.1331 1.1322 0.67...0.69 1.3245 0.44321 0.55031 0.50284 1.0976 0.43556 0.29093 0.30541 0.32866 0.64442 0.55086 0.04235 0.30902 1.2674 1.3168 0.69...0.74 3.7642 1.6077 1.9693 1.9623 3.2261 1.7035 0.32211 0.37632 0.44394 2.3282 1.7469 0.47252 1.4488 3.5107 3.7621 0.74...0.76 1.7605 0.99018 0.92261 1.0226 1.6677 0.83453 0 0 0 1.3357 0.83708 0.012675 0.82165 1.9712 1.7771 0.76...0.78 1.793 1.0871 1.0651 1.1846 1.7133 0.97714 0 0 0 1.4779 0.93283 0.32703 0.95542 1.9453 1.7702 0.78...0.80 2.0858 1.366 1.3302 1.5257 2.0392 1.2819 0 0 0.023345 1.871 1.19 0.82077 1.2349 2.2369 2.0448 0.80...0.82 2.1204 1.4942 1.4642 1.6868 2.1737 1.3985 0.11125 0.10194 0.13924 2.0698 1.4629 1.037 1.4277 2.4095 2.0958 0.82...0.84 2.4114 1.7744 1.8196 2.0381 2.5105 1.7371 0.69378 0.66515 0.68707 2.494 1.8895 1.5676 1.7358 2.6967 2.3733 0.84...0.89 7.9993 6.6792 7.0892 7.7032 8.7475 7.1664 7.4904 5.6546 7.6081 9.5502 8.4931 7.9148 7.1409 8.7184 7.6667 0.89...0.91 4.0382 3.0903 3.5895 3.6456 4.104 3.3389 2.4227 2.3828 2.5005 4.3228 3.5735 3.7518 3.0919 3.8687 3.8497 0.91...0.97 13.615 11.955 13.415 13.345 14.442 12.953 10.77 11.027 10.964 15.906 13.689 16.324 11.538 13.477 12.053 0.97...1.02 6.7423 5.7504 5.9729 5.7993 6.9394 5.1435 3.5847 3.8138 3.7794 7.2646 5.4158 6.3833 4.4158 6.9002 6.118 1.02...1.06 4.7665 3.6523 3.5893 3.4847 4.5671 2.469 2.239 2.3733 2.2799 4.5869 2.7719 3.0993 2.0474 4.8191 4.3653 1.06...1.08 1.2777 0.76391 0.62941 0.60853 1.0611 0 0 0 0 1.0083 0.046619 0 0.0022844 1.333 1.2583 1.08...1.10 1.4185 0.79253 0.6965 0.69003 1.1663 0.017588 0.001951 0 0 1.0581 0 0.029651 0.014031 1.4377 1.3638 1.10...1.13 1.9543 1.0806 1.0668 1.0661 1.6286 0.15536 0 0.0086538 0.033782 1.5439 0.10991 0.18593 0.20135 1.9812 1.8649 1.13...1.15 1.4961 0.80958 0.87743 0.82015 1.2266 0.1369 0.0060293 0.032669 0.061056 1.1827 0.085283 0.19289 0.21371 1.5083 1.4318 1.15...1.17 2.1682 1.9232 2.0309 1.1359 1.5271 0.48547 0.37004 0.42461 0.4261 2.3956 0.39555 1.6631 1.3389 2.3628 2.3317 1.17...1.20 3.5274 2.7363 3.2565 2.9059 3.3473 2.0496 3.2989 3.3832 3.4011 3.8905 2.4957 3.0477 1.9442 3.108 2.8144 1.20...1.22 2.5323 1.6345 1.7881 1.887 2.2761 1.1159 1.4497 1.3393 1.561 2.4243 1.4527 1.4514 1.1285 2.5116 2.4311 1.22...1.25 2.1587 1.364 1.575 1.6547 1.97 0.94769 2.3349 1.6103 2.3013 2.0402 1.3245 1.2751 0.9934 2.2044 2.0515 1.25...1.29 5.416 3.0916 4.0507 4.4488 4.9313 2.9339 10.067 5.8946 10.186 4.9599 3.8784 3.5576 3.1478 5.5914 5.0414 1.29...1.35 38.116 37.523 37.058 39.72 39.798 40.668 40.21 40.334 42.008 40.182 40.151 44.661 38.156 36.869 39.142 1.35...1.37 2.0967 1.8331 1.5556 1.4141 1.8705 1.115 1.3885 1.0029 1.8886 2.3481 1.3681 1.311 0.79736 1.956 1.8554 1.37...1.43 5.7373 4.604 4.7255 4.4521 5.3065 3.4601 3.2568 2.4696 4.1458 6.2325 4.2981 4.3867 2.9088 5.3943 5.3045 1.43...1.48 12.882 11.677 12.725 12.822 13.457 12.117 11.413 10.822 12.082 15.352 12.74 15.987 11.127 12.47 12.156 1.48...1.53 3.6739 3.0913 2.6834 2.5724 3.243 1.9423 1.0088 0.027463 1.5973 3.9757 2.1538 2.5195 1.6131 3.6116 3.348 1.53...1.55 2.065 1.6427 1.4168 1.4549 1.7924 1.0053 0.64638 0 0.99875 2.1556 1.0007 1.1525 0.87948 2.0891 1.8856 1.55...1.57 1.6975 1.2944 1.1875 1.1872 1.4437 0.78044 0.58266 0 0.87508 1.7515 0.80198 0.89051 0.6792 1.6753 1.5664 1.57...1.59 1.8473 1.371 1.3887 1.3506 1.5922 0.9549 0.81851 0.097531 1.0702 1.8864 1.0178 1.1013 0.8418 1.7633 1.6972 1.59...1.61 2.0604 1.6216 1.6722 1.5951 1.822 1.1955 0.79894 0 1.0053 2.1436 1.2722 1.4981 1.0635 1.9439 1.9036 1.61...1.64 2.9312 2.2957 2.4678 2.3073 2.5845 1.7864 1.0834 0 1.2721 3.0133 1.8901 2.2851 1.5499 2.6305 2.7286 1.64...1.70 7.9696 6.4463 7.2013 6.8009 7.3107 5.7127 3.9898 1.8861 4.4167 8.6879 6.0685 7.5075 4.9332 7.3375 7.3912 1.70...1.73 4.6716 4.1934 4.4972 4.3315 4.559 3.7924 3.0613 2.0922 3.2537 5.4416 4.1194 5.1503 3.3666 4.6822 4.1653 1.73...1.79 9.7971 8.9649 9.5414 9.1478 9.8685 8.3624 11.22 10.367 11.375 11.839 9.4992 11.04 8.0271 9.33 9.4112 1.79...1.82 2.099 1.7092 1.5529 1.4916 1.7171 1.0245 0.36498 0 0.63259 2.1893 1.2043 1.308 0.88182 1.9855 1.9774 1.82...1.85 2.6016 2.2513 2.1431 2.0216 2.2371 1.4295 0.63903 0.090656 0.9241 2.9158 1.6683 1.9418 1.2836 2.5609 2.4466 1.85...1.87 1.9702 1.6226 1.5946 1.5528 1.6724 1.1247 0.54439 0.11346 0.65372 2.2096 1.2278 1.493 0.97985 1.9176 1.8458 1.87...1.92 7.2299 6.5224 7.2655 6.876 6.9815 6.0857 5.7899 4.8685 6.0901 8.698 6.6195 8.1032 5.5976 6.7068 6.0829 1.92...1.94 2.1749 2.0817 2.0159 1.964 2.0624 1.5747 1.1182 0.7142 1.2529 2.728 1.9695 2.1427 1.4935 2.2937 2.0099 1.94...1.96 1.6922 1.5176 1.3775 1.3923 1.4932 1.0549 0.67361 0.28465 0.78845 2.0588 1.3967 1.4357 1.0133 1.804 1.6028 1.96...1.99 2.409 2.1186 1.9854 2.0707 2.1447 1.6313 1.3152 0.75089 1.4323 2.8589 2.1071 2.2452 1.584 2.5172 2.253 1.99...2.01 2.4252 2.0691 2.1514 2.1632 2.1796 1.8188 1.9379 1.3364 2.0033 2.8908 2.2847 2.4413 1.6734 2.3876 2.2526 2.01...2.07 7.6324 7.6672 8.0837 7.3462 7.3481 6.6204 6.7305 5.3874 6.9895 10.222 7.8626 9.3079 6.6368 7.6177 7.1399 2.07...2.09 2.4147 2.3389 2.3469 2.2737 2.2778 1.9921 1.3576 1.0528 1.3974 3.059 2.2082 2.5567 1.895 2.5423 2.2954 2.09...2.11 2.5751 2.3938 2.4362 2.417 2.3792 2.0697 1.7081 1.3675 1.8013 3.2224 2.368 2.802 1.9706 2.6208 2.3542 2.11...2.17 16.663 17.038 15.264 17.218 16.88 17.081 15.058 15.095 15.534 20.464 17.982 22.25 15.782 16.295 14.443 2.17...2.21 3.7108 3.6092 2.8601 3.0416 3.1261 2.6906 1.7955 1.5399 2.0918 4.4962 2.9136 3.3524 2.3491 3.5587 3.4181 2.21...2.23 1.7578 1.5732 1.3135 1.3071 1.3052 0.99615 0.56066 0.32451 0.68521 1.9783 1.2785 1.2803 0.95108 1.66 1.6437 2.23...2.27 2.9977 2.9979 2.6262 2.6407 2.5489 2.191 1.5061 1.2553 1.8306 3.5942 2.6908 2.7821 2.2339 3.1134 2.7383 2.27...2.32 4.4165 3.8854 3.8796 3.6333 3.4803 2.8981 2.6699 2.3634 2.9521 5.2074 3.776 3.8584 2.5527 4.0993 3.9013 2.32...2.37 4.5293 4.5336 4.9723 4.1764 3.9727 3.555 4.0428 3.873 4.202 5.8169 4.1907 4.8716 3.1924 4.4097 4.0761 2.37...2.41 2.8057 3.0375 2.9216 2.7489 2.5356 2.2663 1.6688 1.6347 1.8508 3.7174 2.934 2.8778 2.0128 3.2581 3.1792 2.41...2.47 7.8523 7.5016 6.5305 7.2947 6.8164 6.7369 6.6001 6.7877 6.7739 8.4224 8.1133 8.9235 6.3212 7.7132 6.5644 2.47...2.50 1.7277 1.583 1.1746 1.1839 1.014 0.81247 0.62583 0.62715 0.6652 1.9523 1.0916 1.1148 0.74022 1.745 1.5936 2.50...2.52 1.4832 1.4501 1.1826 1.2501 1.0693 0.97877 0.78487 0.96554 0.79287 1.9595 1.2105 1.4006 0.87351 1.4804 1.3827 2.52...2.57 7.0737 7.5839 6.2188 6.7958 6.2762 6.3686 5.3499 5.602 5.5428 9.3593 6.3585 8.0663 5.6452 6.7937 6.4975 2.57...2.60 1.3377 1.2073 0.6987 0.62948 0.38197 0.18783 0 0.025829 0 1.5148 0.44863 0.24929 0.16317 1.3486 1.2887 2.60...2.66 2.4331 2.2173 1.4825 1.4987 0.97257 0.7862 0.75342 0.91966 0.83057 2.7085 1.5302 0.96167 0.80885 2.4417 2.2493 2.66...2.70 1.2374 1.1105 0.7069 0.60121 0.21172 0.097716 0.28768 0.47281 0.26129 1.2951 0.61587 0.1187 0.15862 1.3066 1.2403 2.70...2.72 0.69811 0.60035 0.37781 0.29038 0.034244 0 0 0 0 0.75528 0.26542 0.013965 0 0.7572 0.69393 2.72...2.78 1.8565 1.6026 1.0063 0.9013 0.17631 0.16466 0.33865 0.050773 0.26786 2.055 0.94564 0.30876 0.17953 1.9927 1.8488 2.78...2.80 0.75657 0.66713 0.3012 0.31778 0 0.0023813 0.2538 0.008935 0.21054 0.79958 0.40293 0.024798 0 0.83322 0.78403 2.80...2.82 0.64387 0.57966 0.31363 0.31011 0.032298 0.063007 0.26274 0.025046 0.22507 0.7076 0.39921 0.095186 0.033845 0.70674 0.64569 2.82...2.84 0.69917 0.64189 0.39305 0.38553 0.10507 0.12982 0.11068 0 0.037614 0.80164 0.34706 0.20208 0.078593 0.7717 0.70914 2.84...2.87 0.89304 0.82741 0.56355 0.57034 0.24561 0.30741 0.12807 0.079333 0.081774 1.074 0.54275 0.47954 0.21913 1.0009 0.88953 2.87...2.89 0.73389 0.6591 0.44088 0.45852 0.1503 0.2258 0.070084 0 0.0010423 0.88842 0.44274 0.35119 0.13851 0.85835 0.77811 2.89...2.94 8.0668 8.3122 8.1603 8.0786 7.5111 7.9063 11.351 11.426 10.911 10.755 8.8613 10.337 7.5607 8.0934 7.9865 2.94...3.00 6.9253 7.5331 6.5574 7.1047 6.2438 6.9587 4.7163 4.6522 4.6723 9.6968 7.4378 9.004 5.8924 7.0858 6.5547 3.00...3.05 4.6194 4.8563 5.152 4.7842 3.9926 4.5429 3.8119 3.5934 3.7195 6.2141 5.7431 5.9926 3.9002 4.9873 4.331 3.05...3.09 2.622 1.7721 1.9644 1.7207 1.1935 1.5108 1.2186 0.88101 1.165 2.3847 1.8929 1.9121 0.62629 1.9373 2.4839 3.09...3.15 2.818 2.9081 2.4629 2.372 1.5757 2.1685 1.7375 1.3304 1.6035 3.8094 3.3207 3.0334 1.5983 3.2129 2.8395 3.15...3.17 1.4228 1.4812 1.4148 1.3139 0.8098 1.2381 0.97142 0.62999 0.91874 1.9722 1.9487 1.8109 0.8272 1.6895 1.5031 3.17...3.20 5.49 6.2574 6.3168 7.3078 6.5494 7.5779 5.8242 5.4146 5.7796 9.9882 10.039 10.556 7.13 6.9805 6.0257 3.20...3.23 12.433 13.97 14.537 15.271 14.283 16.065 20.205 19.288 20.277 16.178 17.043 17.507 15.07 15.029 15.088 3.23...3.27 40.247 43.742 57.669 48.314 46.423 50.625 58.579 60.089 58.873 42.61 60.968 48.874 52.78 40.775 37.775 3.27...3.33 6.2305 6.9471 6.0636 5.8156 5.2134 5.9961 4.6357 4.9402 4.6003 7.4029 6.4669 6.7948 5.5664 6.5489 6.0513 3.33...3.35 1.1593 1.2011 0.89631 0.88393 0.57014 0.94485 0.78727 0.53492 0.75 1.4785 1.2921 1.1978 0.54317 1.2112 1.1221 3.35...3.37 1.4348 1.5068 1.2117 1.2045 0.78775 1.3542 1.0064 0.63043 0.97526 1.8553 1.7011 1.657 0.84161 1.5321 1.4752 3.37...3.43 62.728 67.511 67.147 69.518 66.389 73.224 85.096 87.272 85.561 61 80.796 65.044 77.206 61.006 61.202 3.43...3.48 53.938 57.927 55.268 58.971 56.976 62.012 72.104 75.039 72.449 56.457 60.261 57.577 66.637 51.995 54.21 3.48...3.50 7.4646 7.9219 7.5694 7.8672 7.6933 8.2107 8.8266 9.2557 8.8052 8.0876 8.0712 8.0093 8.6892 7.1068 7.4333 3.50...3.54 19.5 20.82 19.994 21.458 20.589 22.503 25.328 25.937 25.439 21.471 22.4 21.971 23.373 18.777 19.432 3.54...3.57 14.817 15.003 14.603 15.225 14.528 16.013 15.378 15.43 15.366 13.3 14.297 14.099 14.826 13.96 14.938 3.57...3.62 17.593 20.609 19.513 18.303 17.552 19.352 15.785 15.905 15.794 11.454 15.296 11.022 19.492 20.038 20.639 3.62...3.67 29.697 34.134 31.565 29.517 28.324 31.486 26.615 26.698 26.685 20.478 23.998 20.392 30.963 32.515 33.642 3.67...3.73 61.169 67.18 64.19 66.475 64.028 70.424 74.701 76.993 75.165 58.017 64.809 59.119 74.55 61.783 63.954 3.73...3.78 55.793 61.66 58.418 60.425 58.61 63.49 60.974 63.051 60.995 52.893 56.469 55.223 65.165 56.418 56.836 3.78...3.80 6.2907 7.0597 6.642 6.6388 6.4093 7.0216 5.6776 5.5377 5.6327 6.3299 6.5628 6.4781 6.5121 6.5468 6.5585 3.80...3.86 71.455 80.358 76.097 75.187 73.297 79.087 75.625 78.416 75.721 59.05 67.956 60.08 83.714 74.506 76.38 3.86...3.91 46.691 50.034 52.896 51.706 50.909 53.833 57.611 60.151 57.263 46.311 50.778 48.538 57.918 47.04 48.598 3.91...3.97 18.265 20.288 20.81 18.801 18.746 19.036 15.827 15.332 14.979 13.023 15.141 12.793 19.946 19.901 20.147 3.97...4.02 8.5269 8.6776 9.3832 9.0738 9.078 9.0851 7.7807 7.1427 7.0714 9.6822 9.4697 10.1 9.7331 8.5452 8.4007 4.02...4.07 6.4724 6.0297 6.1427 6.678 6.6355 6.6426 4.6343 3.5906 3.9149 7.7118 6.8642 8.1456 6.1333 6.1043 6.2818 4.07...4.13 10.011 10.183 10.303 10.909 10.546 11.101 9.7025 7.7648 8.8752 11.591 11.109 12.71 9.5435 9.5595 9.8886 4.13...4.15 1.2609 1.275 1.3343 1.3084 1.3148 1.2612 1.1484 0.51726 0.82727 1.6085 1.4694 1.639 0.84691 1.1052 1.0613 4.15...4.20 3.1884 3.2559 3.0887 3.2947 3.2557 3.3069 2.8972 1.4386 2.1609 4.1528 3.7601 4.3744 2.2251 2.9954 2.9225 4.20...4.25 3.9853 4.0295 3.9068 4.1297 4.0015 4.2657 3.2627 1.6235 2.4901 5.1156 4.764 5.4562 2.6622 3.6283 3.5975 4.25...4.29 3.7492 3.9297 4.1483 4.2727 4.2192 4.4652 3.5996 2.1858 2.9698 5.2261 5.3873 5.9717 3.3199 3.7512 3.5227 4.29...4.35 3.871 4.1153 4.2146 4.3697 4.2238 4.5607 3.6626 1.7033 2.8032 5.1877 5.0106 5.5923 2.8277 4.0963 3.9323 4.35...4.41 3.8383 3.819 3.5513 4.0424 3.8787 4.2355 2.6653 0.4451 1.7662 4.9573 4.5812 5.377 2.2885 3.4615 3.6333 4.41...4.46 2.7544 2.9977 3.0719 3.1743 2.9959 3.3722 2.5737 0.97324 1.7295 3.8207 4.0756 4.3847 1.4775 2.6159 2.5306 4.46...4.52 2.1711 2.2621 1.8161 2.1597 1.9821 2.3836 1.5172 0.34233 0.64936 2.827 2.6485 2.973 0.81232 1.861 1.9824 4.52...4.55 0.70465 0.78593 0.59703 0.64721 0.56811 0.78321 0.51722 0.027052 0.035756 0.87715 0.84961 0.95164 0 0.54457 0.63752 4.55...4.60 1.6985 2.0268 1.5008 1.5745 1.4464 2.052 1.2217 0.32784 0.73827 2.4237 1.9819 2.5172 0.53787 1.3488 1.4403 4.60...4.66 15.114 16.572 15.577 16.516 15.806 17.573 19.589 20.201 19.71 14.683 16.382 15.329 18.468 14.323 15.326 4.66...4.70 0.23738 0.13575 0.12341 0.11712 0.13974 0.072817 0.031276 0.023488 0.00034921 0.026877 0.041324 0.019973 0.14246 0 0.14462 4.85...4.88 0.0022414 0 0 0.0015242 0 0 0 0 0 0 0 0 0 0 0 4.88...4.93 0.23923 0.15337 0.14939 0.22988 0.15227 0.10833 0 0.11484 0 0.070022 0.24457 0.16283 0.21904 0 0.15074 4.93...4.99 0.28542 0.026696 0.29919 0.31713 0.29242 0.099095 0.11914 0.53573 0.30986 0.12255 0.49066 0.20903 0.42982 0.050825 0.30841 4.99...5.02 0.07372 0 0.027578 0.016997 0 0 0 0 0 0 0.0058165 0 0.0022191 0 0.0051834 5.02...5.05 0.045355 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.05...5.07 0.02688 0 0 0 0 0 0 0 0 0.0036589 0 0.0017252 0 0 0.001748 5.07...5.11 0.25202 0.17356 0.1528 0.21573 0.16237 0.20969 0.17622 0.10994 0.10735 0.2095 0.14239 0.19526 0.16414 0.10139 0.19246 5.11...5.16 0.17288 0.0089207 0.00025567 0.050762 0 0.096896 0.0098088 0 0 0.18755 0.018374 0.18101 0 0 0.059149 5.16...5.18 0.40744 0.43545 0.40014 0.35722 0.3168 0.48544 0.16983 0.22935 0.26655 0.41667 0.41664 0.42428 0.35798 0.35927 0.42103 5.18...5.20 0.056105 0.18232 0.0067724 0 0 0.21972 0 0.010393 0.14164 0.20224 0.29114 0.25528 0 0.041956 0.068405 5.20...5.26 14.561 15.245 14.75 15.565 15.006 16.31 17.893 18.446 18.074 13.303 14.9 13.624 17.6 14.092 14.871 5.26...5.30 0.32212 0 0 0 0.00067368 0 0 0 0 0 0.11009 0 0 0.15758 0.2479 5.30...5.32 0.18247 0.012376 0.0080734 0.026045 0 0.023676 0.13324 0.045026 0.031986 0 0.22886 0 0 0.081716 0.166 5.32...5.34 0.57063 0.37791 0.45697 0.45872 0.39022 0.55355 0.8445 0.81996 0.71723 0.10568 0.96278 0.11288 0.60557 0.45746 0.69242 5.34...5.37 0.74839 0.70677 0.72575 0.73769 0.66371 0.93599 1.1132 1.2105 1.0198 0.37339 1.3406 0.41741 1.022 0.69449 0.98329 5.37...5.43 13.319 15.535 13.604 12.02 11.765 12.636 8.3223 8.9713 8.2187 4.1191 7.1178 3.3196 13.572 14.877 15.379 5.43...5.48 0.49969 0.041809 0 0.10436 0.11701 0 0.019839 0.047137 0 0.0062905 0.066504 0.0035851 0.12108 0.2662 0.45129 5.48...5.52 0.35864 0.065324 0.068589 0.0052678 0.016257 0 0.0079296 0.020622 0.0087831 0 0.0039153 0.012791 0 0.11983 0.31539 5.52...5.58 0.2312 0 0.0025358 0 0 0.00086196 0.0087049 0.0056461 0.0018486 0 0.0070715 0.013394 0 0 0.15811 5.58...5.61 0.041984 0 0 0 0.0005727 0 0 0 0 0 0.001126 0 0 0 0.019458 5.61...5.65 0.04014 0.003906 0.013541 0.043891 0.043933 0.023245 0.0089175 0.024087 0.018121 0.045401 0.063972 0.068977 0.031014 0 0.031207 5.65...5.70 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.70...5.74 0 0.0054788 0.0029559 0 0.0014369 0 0.0036258 0 0 0.0020015 0 0.0018614 0 0 0 5.74...5.77 0 0.00068373 0 0 0 0.001876 0.0053658 0 0.0079979 0 0 0.0064374 0 0 0 5.77...5.82 0 0.0021827 0.06494 0.042673 0.018363 0.019188 0 0.02025 0 0.025648 0.034528 0.071192 0.018892 0 0 5.82...5.86 0 0.018187 0 0.012503 0 0.011803 0 0.034231 0 0 0.0058018 0.03838 0.0023903 0 0 5.86...5.92 0.73366 0.85498 0.72522 0.88979 0.80976 0.94922 0.7939 0.85627 0.80425 0.98568 1.0519 1.1486 0.8062 0.44784 0.55411 5.92...5.94 0.038239 0.047686 0.034572 0.059721 0.062723 0.074358 0 0 0 0.086931 0.038059 0.084449 0.078652 0 0.019065 5.94...6.00 0.5611 0.57839 0.58602 0.64458 0.63913 0.70573 0.041483 0.1765 0.071441 0.72304 0.68658 0.85008 0.63298 0.27053 0.51313 6.00...6.04 0 0 0 0.0031231 0.0050101 0.0012017 0 0 0 0.00095486 0 0 0 0 0 6.04...6.07 0 0.0013369 0 0 0 0 0 0 0 0 0 0 0 0 0 6.07...6.11 0.944 1.1261 1.3871 1.3188 1.3061 1.4127 1.1921 1.3282 1.1914 1.4776 1.6806 1.8344 1.238 0.8184 0.91209 6.11...6.17 0.78396 0.7522 0.64722 0.87197 0.87058 0.91017 0.35077 0.59375 0.3153 1.0432 0.78271 1.1304 0.90552 0.50858 0.8064 6.17...6.20 0 0 0.017335 0 0.0123 0.011494 0 0 0 0.0095151 0.0071195 0.0055664 0.024861 0 0 6.20...6.24 0 0.011041 0.00038969 0.0099571 0 0.0041621 0.009181 0.014179 0 0.0054228 0.0019912 0.027603 0.0093858 0 0 6.24...6.28 0 0 0.0026433 0 0 0.00089059 0 0 0.0081327 0 0 0 0 0 0 6.28...6.32 0 0 0.002829 0.0020453 0.0019174 0 0 0 0 0.0049674 0.0031096 0.0030722 0 0 0 6.32...6.35 0 0.0064621 0 0 0 0.0015567 0.0026897 0.0013726 0 0 0.0022563 0 0 0 0 6.35...6.37 0 0 0.0045319 0 0.0095725 0 0 0.0037504 0.005929 0.0014526 0 0.0045639 0 0 0 6.37...6.40 0 0 0 0.0037747 0 0.00043266 0.0049041 0 0 0.00086661 0.0099467 0 0.0060507 0 0 6.40...6.44 0 0.001285 0.0014906 0 0.0065043 0 0.0032573 0 0 0 0 0 0 0 0 6.44...6.47 0.014531 0 0.00041196 0.0020953 0 0 0 0.011684 0.0010548 0 0.0078149 0.0011567 0.0032393 0 0 6.47...6.53 0.17503 0.14627 0.17157 0.15807 0.14187 0.14568 0.33158 0.24043 0.29974 0.15246 0.17877 0.19676 0.18451 0 0.17395 6.53...6.58 0.027667 0 0 0 0 0.0016114 0 0 0 0 0.0067777 0.022923 0 0 0.043346 6.58...6.60 0.039418 0 0 0 0.015447 0 0 0.0014462 0.0051971 0.0031771 0.028782 0.072046 0 0 0.029975 6.60...6.63 0.1716 0.019505 0.065528 0.0098506 0.12638 0.029902 0.017796 0.003222 0 0.10087 0.19798 0.27261 0.0098934 0.056758 0.15926 6.63...6.68 0.2113 0.0070288 0.01887 0.0006497 0.14876 0.01319 0 0.00003314 0.0031256 0.14601 0.26567 0.34508 0 0.073823 0.20474 6.68...6.70 0.087285 0 0 0.0023966 0.050222 0 0.0030618 0 0 0.051732 0.14608 0.14805 0 0.010289 0.085163 6.70...6.72 0.089724 0.0049961 0 0 0.078516 0.0028988 0 0.013599 0.0019165 0.07657 0.19331 0.17324 0.0025382 0.046495 0.10433 6.72...6.74 0.11564 0 0 0 0.1181 0 0 0 0.000068381 0.13526 0.23575 0.25196 0 0.052558 0.12767 6.74...6.78 0.33792 0.032038 0 0 0.32577 0.055487 0 0.0028363 0 0.43138 0.55041 0.64207 0 0.25644 0.35226 6.78...6.84 0.77146 0.10624 0.11635 0.11739 0.8052 0.19168 0.027453 0.017207 0.013147 0.96864 1.108 1.3484 0.08558 0.62016 0.74734 6.84...6.87 0.34693 0.0025808 0 0 0.31103 0.0017886 0 0 0 0.43331 0.42044 0.61651 0.0064192 0.22917 0.30096 6.87...6.92 0.7248 0.27653 0.36864 0.37578 0.75888 0.36184 0.55898 0.52601 0.51274 0.92533 0.97394 1.3438 0.33874 0.58425 0.63136 6.92...6.97 0.50565 0.067716 0.0034243 0.0020449 0.48344 0.0053165 0 0 0 0.67886 0.6596 0.95394 0.008965 0.3675 0.50533 6.97...7.00 0.28733 0.064394 0 0 0.26795 0 0.000112 0 0 0.39804 0.44421 0.55052 0 0.20212 0.28137 7.00...7.04 0.48203 0.19608 0.016359 0.015676 0.44094 0.016262 0 0.0017454 0 0.68977 0.65437 0.90686 0.0087663 0.33937 0.44095 7.04...7.06 0.17761 0.08298 0 0 0.16421 0 0 0 0.021992 0.31859 0.37739 0.43447 0 0.12319 0.17943 7.06...7.09 0.38844 0.29938 0.186 0.14697 0.39149 0.23519 0.19148 0.20105 0.22599 0.60999 0.73651 0.87335 0.14352 0.31938 0.32558 7.09...7.15 0.65775 0.54167 0.18395 0.0079702 0.63467 0.40018 0.0043122 0.0018839 0 1.182 1.4132 1.5355 0.010506 0.52383 0.6661 7.15...7.17 0.18915 0.23026 0.0049485 0 0.1786 0.15541 0 0 0.010185 0.43144 0.5058 0.5423 0 0.14953 0.1887 7.17...7.22 1.2875 1.3904 1.0403 0.89179 1.3638 1.4175 1.2728 1.2786 1.2244 2.2122 2.4301 2.7917 0.88772 1.1629 1.1705 7.22...7.23 0.075269 0.11 0.0020745 0.0055337 0.068374 0.08344 0 0.0089178 0.0027193 0.19559 0.24189 0.23968 0 0.053889 0.066028 7.34...7.40 32.351 29.595 38.229 37.045 36.684 34.675 40.744 63.977 38.892 25.305 20.668 46.18 42.482 35.355 31.179 7.40...7.44 1.1436 0.1645 0.96915 0.69617 1.3077 0.29902 0.70333 0.71888 0.2162 0.30372 0.30968 0.51503 1.2417 1.0689 1.0412 7.44...7.50 1.1076 0.22023 0.83892 0.33283 1.2658 0.29074 0.6237 0.69437 0.62317 0.35945 0.31533 0.56039 1.1077 1.0034 1.0917 7.50...7.55 0.57255 0 0.30911 0.033059 0.56511 0 0 0 0 0 0 0.047848 0.32709 0.37934 0.52967 7.55...7.61 0.83065 0.40984 0.60289 0.55237 0.87768 0.48916 0.58263 0.58361 0.54492 0.4825 0.51269 0.69609 0.58084 0.66895 0.80601 7.61...7.63 0.21801 0 0.048544 0 0.17348 0 0 0 0.0015257 0 0 0 0 0.10189 0.20772 7.63...7.69 0.41246 0 0.12677 0.0076638 0.33704 0 0.0045256 0 0.0034472 0 0.0063227 0.0065848 0.002365 0.19322 0.39306 7.69...7.74 0.27747 0.02135 0.051442 0.01346 0.19473 0.036444 0.0042252 0.0096108 0.0054749 0 0 0 0.017309 0.11881 0.24648 7.74...7.78 0.16192 0 0 0 0.090882 0.0017474 0 0 0 0 0 0 0 0.0059311 0.1392 7.78...7.80 0.083478 0 0.0034481 0 0.035072 0.000090625 0 0.0021517 0.0028358 0 0 0 0 0.018476 0.086603 7.80...7.83 0.10162 0 0 0 0.01585 0 0 0 0.00027207 0 0 0 0 0.0010254 0.080518 7.83...7.89 1.012 0.87151 0.8781 0.93661 1.046 0.97963 0.88489 0.90863 0.90728 0.99014 1.0427 1.2264 0.93594 0.84508 0.92371 7.89...7.91 0.10317 0 0 0.0021638 0.070025 0 0 0 0 0 0 0 0.0065617 0.04842 0.11115 7.91...7.97 0.74666 0.49218 0.60429 0.54408 0.72367 0.57214 0.30063 0.3101 0.35576 0.69633 0.7308 0.84051 0.53256 0.61924 0.77334 7.97...8.03 0.34115 0.074062 0.057578 0.015672 0.21835 0.0074937 0.0081337 0.009227 0 0.10427 0.17367 0.14333 0.0030502 0.16228 0.35886 8.03...8.06 0.13443 0 0 0 0.049558 0 0 0 0 0.018381 0.020944 0.01042 0 0.034245 0.12029 8.06...8.11 0.41726 0.083597 0.05994 0.10057 0.25186 0.090528 0.028749 0.017497 0.013791 0.22512 0.23924 0.28151 0.12567 0.18717 0.41206 8.11...8.15 0.12867 0 0.0037419 0 0.020104 0 0 0 0 0.0065351 0.048105 0.044577 0 0.003355 0.11766 8.15...8.19 0.45146 0.35924 0.39396 0.39419 0.39386 0.45873 0.4215 0.3605 0.43438 0.56695 0.58421 0.69507 0.41718 0.36986 0.44815 8.19...8.21 0.26883 0.2506 0.30823 0.28408 0.29212 0.32582 0.35946 0.34268 0.42606 0.4492 0.4416 0.50714 0.2932 0.25129 0.24805 8.21...8.27 1.8468 1.5575 1.7191 1.8776 1.9608 2.0006 1.5981 1.5499 1.6486 2.2775 2.2055 2.6979 1.8041 1.7484 1.8807 8.27...8.30 0.24872 0.022913 0.021298 0.036477 0.17695 0.036906 0 0.0039219 0 0.11754 0.13438 0.14634 0.048319 0.14261 0.26495 8.30...8.36 1.3692 1.2697 1.5243 1.5407 1.6211 1.6125 1.59 1.7964 1.6308 1.7982 2.0573 2.1891 1.4262 1.392 1.4617 8.36...8.39 0.2612 0.010095 0.051164 0.052775 0.1307 0.037409 0.01171 0.084959 0.002523 0.055973 0.069586 0.025719 0.021477 0.11934 0.19662 8.39...8.44 0.27959 0 0 0 0.13928 0 0 0 0 0.057268 0.061668 0.05772 0 0.11809 0.28712 8.44...8.46 0.14742 0 0 0 0.063644 0 0.0065054 0.031975 0.028978 0.076556 0.065059 0.071115 0 0.070548 0.13376 8.46...8.49 0.25698 0.0045952 0.0077666 0 0.15969 0 0 0 0 0.1743 0.12681 0.16766 0 0.13957 0.24222 8.49...8.55 0.66527 0.24125 0.1638 0.26129 0.46081 0.22581 0.014852 0 0.024182 0.62625 0.47997 0.6576 0.20991 0.43506 0.68684 8.55...8.61 0.81251 0.45475 0.24302 0.44123 0.57714 0.44736 0.20075 0.167 0.18704 0.56219 0.42793 0.6226 0.38131 0.59098 0.80597 8.61...8.66 0.2524 0 0 0.00033864 0.078313 0.0019886 0.0064276 0 0 0.050943 0.027436 0 0 0.049662 0.26598 8.66...8.68 0.095856 0.0054 0.01245 0 0.015378 0 0 0 0.025954 0.041361 0.013357 0.015725 0 0.019349 0.084393 8.68...8.73 0.58816 0.39238 0.40709 0.47615 0.47873 0.48851 0.42813 0.44761 0.46973 0.56395 0.50162 0.65711 0.43132 0.43858 0.60966 8.73...8.78 0.1933 0 0.0019132 0 0 0 0.0014717 0 0 0 0 0 0 0.02325 0.20911 8.78...8.80 0.081939 0.0025727 0 0.0010768 0 0 0 0.0015948 0 0.0018626 0 0 0 0 0.08145 8.80...8.85 0.20154 0 0.0031819 0.0015169 0.011597 0.00011013 0.01738 0 0 0 0.056064 0 0.0015769 0.02549 0.20107 8.85...8.90 0.19785 0.0020416 0.0026061 0 0 0 0.0024439 0 0.0039958 0 0.0082328 0.039255 0.000045121 0.033691 0.19648 8.90...8.96 0.53242 0.30642 0.32172 0.36754 0.3324 0.38446 0.28929 0.28933 0.36699 0.41951 0.40181 0.52759 0.32868 0.34271 0.53007 8.96...8.99 0.12225 0 0 0 0 0 0 0 0.0014516 0.0047427 0.00003361 0 0.0020002 0.032167 0.11757 8.99...9.00 0.060959 0 0.0045749 0 0.0042366 0.0022498 0 0.0021609 0.010808 0 0 0 0 0.028816 0.059867 NMR_BINNED_DATA_END #END