#METABOLOMICS WORKBENCH michaelsa93_20160701_111053_mwtab.txt DATATRACK_ID:661 VERSION 1 CREATED_ON November 15, 2016, 8:44 am #PROJECT PR:PROJECT_TITLE Metabolic profiling during ex vivo machine perfusion of the human liver PR:PROJECT_SUMMARY As donor organ shortages persist, functional machine perfusion is under PR:PROJECT_SUMMARY investigation to improve preservation of the donor liver. The transplantation of PR:PROJECT_SUMMARY donation after circulatory death (DCD) livers is limited by poor outcomes, but PR:PROJECT_SUMMARY its application may be expanded by ex vivo repair and assessment of the organ PR:PROJECT_SUMMARY before transplantation. Here we employed subnormothermic (21 °C) machine PR:PROJECT_SUMMARY perfusion of discarded human livers combined with metabolomics to gain insight PR:PROJECT_SUMMARY into metabolic recovery during machine perfusion. Improvements in energetic PR:PROJECT_SUMMARY cofactors and redox shifts were observed, as well as reversal of PR:PROJECT_SUMMARY ischemia-induced alterations in selected pathways, including lactate metabolism PR:PROJECT_SUMMARY and increased TCA cycle intermediates. We next evaluated whether DCD livers with PR:PROJECT_SUMMARY steatotic and severe ischemic injury could be discriminated from PR:PROJECT_SUMMARY ‘transplantable’ DCD livers. Metabolomic profiling was able to cluster PR:PROJECT_SUMMARY livers with similar metabolic patterns based on the degree of injury. Moreover, PR:PROJECT_SUMMARY perfusion parameters combined with differences in metabolic factors suggest PR:PROJECT_SUMMARY variable mechanisms that result in poor energy recovery in injured livers. We PR:PROJECT_SUMMARY conclude that machine perfusion combined with metabolomics has significant PR:PROJECT_SUMMARY potential as a clinical instrument for the assessment of preserved livers. PR:INSTITUTE University of California, Davis PR:DEPARTMENT Genome and Biomedical Sciences Facility PR:LABORATORY WCMC Metabolomics Core PR:LAST_NAME Fiehn PR:FIRST_NAME Oliver PR:ADDRESS 1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, PR:ADDRESS CA 95616 PR:EMAIL ofiehn@ucdavis.edu PR:PHONE (530) 754-8258 PR:FUNDING_SOURCE NIH U24DK097154 PR:PUBLICATIONS Metabolic profiling during ex vivo machine perfusion of the human liver PR:DOI 10.1038/srep22415 #STUDY ST:STUDY_TITLE Metabolic profiling during ex vivo machine perfusion of the human liver (part ST:STUDY_TITLE III) ST:STUDY_SUMMARY As donor organ shortages persist, functional machine perfusion is under ST:STUDY_SUMMARY investigation to improve preservation of the donor liver. The transplantation of ST:STUDY_SUMMARY donation after circulatory death (DCD) livers is limited by poor outcomes, but ST:STUDY_SUMMARY its application may be expanded by ex vivo repair and assessment of the organ ST:STUDY_SUMMARY before transplantation. Here we employed subnormothermic (21 °C) machine ST:STUDY_SUMMARY perfusion of discarded human livers combined with metabolomics to gain insight ST:STUDY_SUMMARY into metabolic recovery during machine perfusion. Improvements in energetic ST:STUDY_SUMMARY cofactors and redox shifts were observed, as well as reversal of ST:STUDY_SUMMARY ischemia-induced alterations in selected pathways, including lactate metabolism ST:STUDY_SUMMARY and increased TCA cycle intermediates. We next evaluated whether DCD livers with ST:STUDY_SUMMARY steatotic and severe ischemic injury could be discriminated from ST:STUDY_SUMMARY ‘transplantable’ DCD livers. Metabolomic profiling was able to cluster ST:STUDY_SUMMARY livers with similar metabolic patterns based on the degree of injury. Moreover, ST:STUDY_SUMMARY perfusion parameters combined with differences in metabolic factors suggest ST:STUDY_SUMMARY variable mechanisms that result in poor energy recovery in injured livers. We ST:STUDY_SUMMARY conclude that machine perfusion combined with metabolomics has significant ST:STUDY_SUMMARY potential as a clinical instrument for the assessment of preserved livers. ST:INSTITUTE University of California, Davis ST:DEPARTMENT Genome and Biomedical Sciences Facility ST:LABORATORY WCMC Metabolomics Core ST:LAST_NAME Fiehn ST:FIRST_NAME Oliver ST:ADDRESS 1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, ST:ADDRESS CA 95616 ST:EMAIL ofiehn@ucdavis.edu ST:PHONE (530) 754-8258 ST:STUDY_COMMENTS The first 4 samples were a test run to see how efficient the analysis was and ST:STUDY_COMMENTS were run on a lipidomics platform. The next 12 samples were the used in the ST:STUDY_COMMENTS paper and were the same as the original 4 samples, but they were split into 3 ST:STUDY_COMMENTS biological replicates and run on the GC platform. ST:PUBLICATIONS doi:10.1038/srep22415 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS 23.0.A_01 Inj09_SA01_BruinCSH.d Collection Time:- Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 23.0.B_02 Inj22_SA02_BruinCSH.d Collection Time:- Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 23.0.C_03 Inj14_SA03_BruinCSH.d Collection Time:- Treatment=steatotic liver; Replicate=3 SUBJECT_SAMPLE_FACTORS 23.1.A_04 Inj06_SA04_BruinCSH.d Collection Time:1 Hr Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 23.1.B_05 Inj10_SA05_BruinCSH.d Collection Time:1 Hr Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 23.1.C_06 Inj20_SA06_BruinCSH.d Collection Time:1 Hr Treatment=steatotic liver; Replicate=3 SUBJECT_SAMPLE_FACTORS 23.2.A_07 Inj01_SA07_BruinCSH.d Collection Time:2 Hr Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 23.2.B_08 Inj05_SA08_BruinCSH.d Collection Time:2 Hr Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 23.2.C_09 Inj17_SA09_BruinCSH.d Collection Time:2 Hr Treatment=steatotic liver; Replicate=3 SUBJECT_SAMPLE_FACTORS 23.3.A_10 Inj12_SA10_BruinCSH.d Collection Time:3 Hr Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 23.3.B_11 Inj24_SA11_BruinCSH.d Collection Time:3 Hr Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 23.3.C_12 Inj21_SA12_BruinCSH.d Collection Time:3 Hr Treatment=steatotic liver; Replicate=3 SUBJECT_SAMPLE_FACTORS 31.0.A_13 Inj04_SA13_BruinCSH.d Collection Time:- Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 31.0.B_14 Inj02_SA14_BruinCSH.d Collection Time:- Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 31.0.C_15 Inj11_SA15_BruinCSH.d Collection Time:- Treatment=steatotic liver; Replicate=3 SUBJECT_SAMPLE_FACTORS 31.1.A_16 Inj15_SA16_BruinCSH.d Collection Time:1 Hr Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 31.1.B_17 Inj23_SA17_BruinCSH.d Collection Time:1 Hr Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 31.1.C_18 Inj03_SA18_BruinCSH.d Collection Time:1 Hr Treatment=steatotic liver; Replicate=3 SUBJECT_SAMPLE_FACTORS 31.2.A_19 Inj13_SA19_BruinCSH.d Collection Time:2 Hr Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 31.2.B_20 Inj08_SA20_BruinCSH.d Collection Time:2 Hr Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 31.2.C_21 Inj19_SA21_BruinCSH.d Collection Time:2 Hr Treatment=steatotic liver; Replicate=3 SUBJECT_SAMPLE_FACTORS 31.3.A_22 Inj16_SA22_BruinCSH.d Collection Time:3 Hr Treatment=steatotic liver; Replicate=1 SUBJECT_SAMPLE_FACTORS 31.3.B_23 Inj18_SA23_BruinCSH.d Collection Time:3 Hr Treatment=steatotic liver; Replicate=2 SUBJECT_SAMPLE_FACTORS 31.3.C_24 Inj07_SA24_BruinCSH.d Collection Time:3 Hr Treatment=steatotic liver; Replicate=3 #COLLECTION CO:COLLECTION_SUMMARY Liver biopsies were snap frozen in liquid nitrogen and stored at ­80. Tissue CO:COLLECTION_SUMMARY was pulverized, while frozen and tissue was aliquoted into .6 ml tubes between CO:COLLECTION_SUMMARY 30 and 70 mg of liver tissue. 3 replicates are provided per sample. CO:COLLECTION_PROTOCOL_FILENAME StudyDesign_BoteBruinsma_072414.pdf CO:SAMPLE_TYPE Tissue CO:STORAGE_CONDITIONS -80 C CO:TISSUE_CELL_QUANTITY_TAKEN between 30 and 70 mg #TREATMENT TR:TREATMENT_SUMMARY 2 livers (names 23 and 31) were perfused for 3 hours, providing 4 time­course TR:TREATMENT_SUMMARY (0, 1, 2, 3) biopsies. 3 replicates for each biopsy (A, B ,C). These were the TR:TREATMENT_SUMMARY only 2 run on the Lipidomics platform. TR:TREATMENT_PROTOCOL_FILENAME StudyDesign_BoteBruinsma_072414.pdf #SAMPLEPREP SP:SAMPLEPREP_SUMMARY 1. Weigh 4mg tissue sample in to a 2mL Eppendorf tube. 2. Add 1mL extraction SP:SAMPLEPREP_SUMMARY solvent to the tissue sample and homogenize for 45 seconds ensuring that sample SP:SAMPLEPREP_SUMMARY resembles a powder. In between samples, clean the homogenizer in solutions of SP:SAMPLEPREP_SUMMARY methanol, acetone, water, and the extraction solvent in the order listed. 3. SP:SAMPLEPREP_SUMMARY Vortex samples for 10 seconds, then 5 minutes on 4°C shaker. 4. Centrifuge the SP:SAMPLEPREP_SUMMARY samples for 2 minutes at 14,000 rcf. Aliquot 500μL supernatant for analysis, SP:SAMPLEPREP_SUMMARY and 500μL for a backup. Store backup aliquots in the -20°C freezer. 5. SP:SAMPLEPREP_SUMMARY Evaporate one 500μl analysis aliquot in the Labconco Centrivap cold trap SP:SAMPLEPREP_SUMMARY concentrator to complete dryness (typically overnight). 6. The dried aliquot is SP:SAMPLEPREP_SUMMARY then re-suspended with 500l 50% acetonitrile (degassed as given) 7. SP:SAMPLEPREP_SUMMARY Centrifuge for 2 minutes at 14,000 rcf using the centrifuge Eppendorf 5415. 8. SP:SAMPLEPREP_SUMMARY Remove supernatant to a new Eppendorf tube. 9. Evaporate the supernatant to SP:SAMPLEPREP_SUMMARY dryness in the the Labconco Centrivap cold trap concentrator. 10. Submit to SP:SAMPLEPREP_SUMMARY derivatization. SP:SAMPLEPREP_PROTOCOL_FILENAME SOP_Extraction_of_Liver_Tissue_Samples.pdf SP:PROCESSING_METHOD Homogenization #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Agilent 6530 CH:COLUMN_NAME Waters Acquity CSH C18 (100 x 2.1mm, 1.7um) CH:COLUMN_NAME 1.7um Pre-Column CH:FLOW_GRADIENT 15% B to 99%B CH:FLOW_RATE 0.6 mL/min CH:COLUMN_TEMPERATURE 65 C CH:METHODS_FILENAME Data_Dictionary_Fiehn_laboratory_CSH_QTOF_lipidomics_05-29-2014.pdf CH:SOLVENT_A 60:40 Acetonitrile:Water +10mM Ammonium Formate +10mM Formic Acid CH:SOLVENT_B 9:1 Isopropanol:Acetonitrile +10mM Ammonium Formate +10mM Formic Acid CH:COLUMN_PRESSURE 450-850 bar CH:INTERNAL_STANDARD See data dictionary CH:RETENTION_TIME See data dictionary CH:SAMPLE_INJECTION 1.67 uL CH:ANALYTICAL_TIME 13 min CH:CAPILLARY_VOLTAGE 3500 V CH:TIME_PROGRAM 15 min CH:WEAK_WASH_SOLVENT_NAME Isopropanol CH:STRONG_WASH_SOLVENT_NAME Isopropanol CH:TARGET_SAMPLE_TEMPERATURE Autosampler temp 4 C CH:RANDOMIZATION_ORDER Excel generated #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME WCMC Metabolomics Core AN:SOFTWARE_VERSION MassHunter AN:DATA_FORMAT .d #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME Agilent 6530 QTOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:CAPILLARY_VOLTAGE 3500 V MS:COLLISION_GAS Nitrogen MS:DRY_GAS_FLOW 8 L/min MS:DRY_GAS_TEMP 325 C MS:FRAGMENT_VOLTAGE 120 V MS:FRAGMENTATION_METHOD Auto MS/MS MS:ION_SOURCE_TEMPERATURE 325 C MS:ION_SPRAY_VOLTAGE 1000 V MS:IONIZATION Pos MS:PRECURSOR_TYPE Intact Molecule MS:REAGENT_GAS Nitrogen MS:SOURCE_TEMPERATURE 325 C MS:DATAFORMAT .d MS:DESOLVATION_GAS_FLOW 11 L/min MS:DESOLVATION_TEMPERATURE 350 C MS:NEBULIZER 35 psig MS:OCTPOLE_VOLTAGE 750 V MS:RESOLUTION_SETTING extended dynamic range MS:SCAN_RANGE_MOVERZ 60-1700 Da MS:SCANNING_CYCLE 2 Hz MS:SCANNING_RANGE 60-1700 Da MS:SKIMMER_VOLTAGE 65 V #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS counts MS_METABOLITE_DATA_START Samples Inj09_SA01_BruinCSH.d Inj22_SA02_BruinCSH.d Inj14_SA03_BruinCSH.d Inj06_SA04_BruinCSH.d Inj10_SA05_BruinCSH.d Inj20_SA06_BruinCSH.d Inj01_SA07_BruinCSH.d Inj05_SA08_BruinCSH.d Inj17_SA09_BruinCSH.d Inj12_SA10_BruinCSH.d Inj24_SA11_BruinCSH.d Inj21_SA12_BruinCSH.d Inj04_SA13_BruinCSH.d Inj02_SA14_BruinCSH.d Inj11_SA15_BruinCSH.d Inj15_SA16_BruinCSH.d Inj23_SA17_BruinCSH.d Inj03_SA18_BruinCSH.d Inj13_SA19_BruinCSH.d Inj08_SA20_BruinCSH.d Inj19_SA21_BruinCSH.d Inj16_SA22_BruinCSH.d Inj18_SA23_BruinCSH.d Inj07_SA24_BruinCSH.d Factors Collection Time:- Collection Time:- Collection Time:- Collection Time:1 Hr Collection Time:1 Hr Collection Time:1 Hr Collection Time:2 Hr Collection Time:2 Hr Collection Time:2 Hr Collection Time:3 Hr Collection Time:3 Hr Collection Time:3 Hr Collection Time:- Collection Time:- Collection Time:- Collection Time:1 Hr Collection Time:1 Hr Collection Time:1 Hr Collection Time:2 Hr Collection Time:2 Hr Collection Time:2 Hr Collection Time:3 Hr Collection Time:3 Hr Collection Time:3 Hr 8.12_636.63_8.12_658.61 5839 6704 8063 7182 7861 7491 8184 8690 7408 6661 7101 8268 9841 10008 8724 8441 11550 10766 13232 9935 10171 14264 10994 12731 7.80_604.60_7.80_622.61_7.81_644.59 9323 9222 10849 10294 9499 11884 12819 12512 10261 9487 10156 12588 11174 11461 10590 11875 15419 13888 18001 13141 13741 20355 15931 17479 8.44_672.63_8.44_632.63_8.44_650.64 16714 18539 20045 19048 17783 19965 21598 22435 18701 16980 18766 21516 19986 20814 18234 16627 23261 20043 27732 19204 20863 28014 21486 24433 7.76_648.63_7.77_630.62_7.77_670.61 14204 14243 16241 17005 15256 18122 18983 19805 16452 14484 16803 19805 21500 20990 19679 21540 28912 25212 33980 24221 24597 34755 29064 29544 4.93_369.35 40156 40807 42887 44544 41461 43407 44405 46403 41162 35163 40204 44323 57631 58091 54376 47603 58747 53932 64597 55438 55370 58935 51919 57629 7.04_617.51_7.05_612.56 41188 41910 51449 44422 43629 47827 56425 54596 50632 43807 44913 50308 13678 13981 11456 8581 12057 9975 16389 12318 12492 16144 11030 13512 7.12_643.53_7.12_638.57 19924 19892 31110 15887 16418 18485 23170 24635 24018 17469 18010 18712 7595 7944 6787 5052 6864 5948 10166 6731 6978 7961 6237 7027 6.56_641.51_6.57_636.56 21704 21594 32515 16276 18384 19562 24531 25550 25661 16648 17864 19153 8727 9655 8547 5361 8126 6633 12129 8405 9052 9301 6736 8425 4.89_862.62 4209 4458 5832 5603 4827 5223 4545 5863 4211 4464 4929 5514 9384 8573 7893 6003 9398 8053 10319 6479 7242 10670 7322 8925 1.59_496.34 44405 48283 51232 33599 36727 27411 41066 53428 46579 21745 36439 36992 59468 56226 49229 11466 15221 14611 19830 11554 10870 16471 10352 13643 2.36_524.37 18950 20558 22723 17930 17515 13673 19655 25291 20503 12230 17916 19343 24241 24975 21249 6485 8540 7822 10193 6976 5617 8993 6307 8935 5.61_760.58_5.63_782.57 2929230 3160354 3500126 3389735 3135612 3171868 3331811 3612097 3090950 2546773 2984410 3356649 2664994 2703077 2375420 2006350 2820659 2386543 3430254 2582337 2608098 2828422 2238478 2541412 10.98_859.78_10.99_876.80_10.99_881.76 9836285 9933985 10595737 10576262 9713775 10045246 10402561 10281219 9671099 9516990 9791833 9906698 8320208 8248611 7813144 5304529 6371447 5851552 7051818 6046051 6421490 7573114 6568853 7219246 4.91_706.54 58063 69956 76482 75673 68818 69902 74213 76081 65054 45486 54599 66951 49952 53056 43643 27548 40962 32661 44502 34129 31483 39814 31634 37771 4.40_704.52 5337 6942 6912 6663 6398 6816 8683 8719 7252 5743 7085 8723 5450 5325 4510 2859 4125 3438 4716 4472 4094 4751 3878 4679 5.21_720.55 10726 11987 13571 12943 11653 12226 13211 12408 11435 8180 9311 10631 8132 8001 7596 5393 8118 6420 9034 6515 6001 7445 5961 6574 5.54_734.57_5.55_756.55 342737 372126 417418 413764 371880 383481 361940 402801 329969 253363 288769 334013 289785 296229 255914 207104 314643 258670 312800 245332 233606 253542 204386 233516 4.99_732.55_4.99_754.54 468655 528399 568505 568782 524269 532315 561837 599749 529455 398122 493858 559585 395932 403917 344162 226586 350022 274829 474683 343434 337898 394039 309800 358968 4.52_730.54 26637 28753 31864 30872 29941 32160 40777 39510 35368 28104 33352 39214 37792 38767 34649 22069 32372 25423 42584 34679 31826 38500 30213 34261 4.90_728.52 3240 3606 3899 4119 3560 3411 4084 4149 3462 2182 3259 3711 3119 3261 2902 2733 2462 3275 2149 2172 2609 2577 5.75_748.58 7810 8101 9616 9084 8416 9199 9467 9917 7619 6453 7142 8014 5394 4869 4589 3679 5492 4395 5301 4611 4532 4754 3666 4530 5.30_746.57 37675 39142 46018 43015 40562 40300 43573 48057 41618 31741 36574 41724 31396 30821 27136 21968 31334 25798 39360 30300 29546 32876 26106 29933 4.82_744.55 21603 23842 27008 25877 24430 26255 28135 30053 25156 19809 23901 25228 29254 30061 26104 20754 29490 23884 39739 29010 26803 31587 24654 27799 5.12_758.57_5.13_780.55 5211861 5621201 6149019 5839273 5498874 5615633 5980944 6408387 5653871 4548658 5296136 5727062 5955778 5967771 5276427 4617639 6200883 5472977 6855244 5532963 5428066 5936746 4914017 5522789 4.70_756.55 89808 100707 112562 107560 97579 103721 107664 117025 102306 77770 92419 105709 104742 103355 92334 66349 95598 77199 128106 93758 94099 107642 85257 100445 4.44_754.54 8754 9939 11163 10188 9527 10201 14788 14161 13117 10085 12417 13998 9142 9945 8850 5278 8099 6433 10741 8606 8130 10248 8199 9086 5.43_772.59 37884 40059 45535 45082 39847 40947 44091 47989 41141 32427 38499 43206 42416 43469 37839 32250 45626 38535 54677 39634 41104 45197 36460 39498 4.92_770.57 5232 6091 6692 6505 5998 5939 6356 6973 6089 5330 5531 6282 8692 8335 7513 5921 8686 6832 10067 7983 7744 8423 6416 7596 4.73_768.55 9500 10239 10894 11338 10025 10511 11843 11955 10610 8455 9588 11567 8212 8255 7765 6209 8122 6949 11349 8237 8661 9540 7023 8487 6.28_788.62 210827 237775 267544 255204 236233 248392 270366 300658 250480 212818 251526 284350 227341 222405 198949 153814 225293 181778 294867 229080 225900 254968 195361 217802 5.77_786.60 1382837 1511065 1687302 1678383 1580509 1581658 1705403 1853664 1588574 1238720 1469334 1651873 1736083 1769436 1517219 1188092 1665326 1396769 2054778 1516301 1493117 1756366 1406473 1572441 5.29_784.58 526273 556518 623855 591419 563467 555126 619733 676908 567545 477060 540282 589050 516072 516776 457048 367113 529900 432534 584289 462508 452947 536347 421790 479374 5.03_782.57_5.03_804.55 2824558 3076904 3386040 3186994 2945434 2972183 3267324 3523455 3014110 2485012 2874868 3249759 2262486 2309893 1990802 1692613 2431661 2048963 2840628 2073502 2082287 2386022 1875201 2164198 4.31_778.54 2844 3493 3322 3037 3602 3143 4989 5355 4443 3318 3869 4595 4038 4156 3933 2542 3421 2864 5418 4275 4331 4384 3816 4161 5.35_796.59 18628 20130 23131 21639 19568 20884 22557 25143 19377 16687 19315 21451 15614 14940 13879 11447 16441 13620 20185 14386 14524 15637 12557 14465 6.35_814.63 7959 8717 9800 9719 9581 9210 9869 10398 8928 7571 8919 9154 9184 9226 8690 6866 9922 8527 12067 8663 8756 9836 7694 9450 5.95_812.62 131001 142845 158960 161672 146018 151770 166936 180568 149088 118575 142069 157445 144574 142866 127668 90724 130979 108932 162596 118747 117782 145728 115236 130381 5.67_810.60_5.66_832.58 864101 933183 1052215 1017520 934374 960191 1016769 1102202 949291 759750 907069 1022094 712852 727346 618233 515856 713504 596514 882365 624248 641627 734876 572579 653045 6.28_810.62 7814 8411 9758 9239 8412 8789 9714 11902 8771 7918 8889 10419 8253 8569 7550 5704 8180 6721 10629 8302 7831 8675 6734 8730 5.07_808.58_5.07_830.57 303887 333604 374167 361788 331602 334587 360349 389662 328401 269891 315035 361080 230100 235250 204926 181599 260414 214817 324602 238717 232400 257054 199215 230122 4.89_806.57_4.89_828.55 798580 930642 1002363 961877 886309 884002 976933 1069020 882117 684605 809088 948872 880904 896284 775768 617798 931082 775073 1391033 922579 955725 1049144 782457 908653 4.39_804.55 4983 5709 6554 5869 5284 6187 8095 8705 6758 5009 6604 6930 5544 5452 4867 3821 5208 4765 7871 5557 5580 6505 5078 6072 6.14_838.63 14585 16038 18310 16997 15681 16323 17513 20055 16678 14147 15970 17684 7115 7287 6777 5366 8015 6009 9584 7384 7188 7841 6396 6792 5.69_836.61_5.68_858.60 56300 60355 72281 66247 60690 62701 72000 74819 62142 51786 59585 67961 41578 42076 37267 27396 41943 33812 56895 39286 40894 45999 37102 39755 5.50_834.60_5.50_856.58 177334 196720 224432 217349 195752 199424 226660 238870 205533 156587 185919 213759 167865 170975 148440 112230 159790 129432 236639 163776 168102 186432 144371 171297 4.93_832.58 33686 36607 39274 37851 34330 35983 43452 46868 37768 29971 35912 42563 52545 53380 44078 39273 61759 50958 88533 60416 60651 63540 47855 56207 4.50_830.57 4288 5139 5627 5645 4847 5574 6948 7951 5952 5001 6135 7438 4316 4237 3442 3679 4800 4905 6808 4868 5528 6077 4601 5442 5.94_720.59 8984 9607 10916 11672 10067 11723 10269 11698 9857 8544 9622 11768 14528 14399 13769 11214 16604 13756 17451 13310 12689 15003 12424 13117 6.05_796.61 5355 5993 6750 7416 6507 7244 6965 7125 5900 5982 6617 7196 7243 6580 6436 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40273 35693 27930 36124 33254 51401 35553 37852 44048 30927 32009 0.61_262.16 35146 33253 29905 27634 33731 31881 43011 28314 29142 43361 25024 29312 0.68_228.20 5232 2125 2083 2589 2465 4032 3182 3909 4939 3032 2579 2427 3144 0.83_249.21 8636 9363 10630 6214 9165 8502 9275 8423 7916 7995 7634 8453 1.59_923.01 10120 2806 43677 4532 5331 45789 15553 47415 7187 40962 3672 1.62_454.29 3206 3565 4150 2435 2697 2140 3286 3986 2776 2551 2972 4794 4315 4166 2244 2003 2081 2276 2.42_482.32 5571 5359 6012 4011 3981 3686 4945 6687 5291 3460 4205 4890 6918 6423 5936 3967 5619 4876 3985 3249 2574 5751 3122 3532 4.36_337.27 2247 2504 2183 5657 5000 4304 3779 4945 4138 5716 4473 3776 5005 4200 4359 4.39_808.51 2360 2549 2825 2968 2785 2439 2903 3111 2606 2474 3010 2818 5401 5208 5175 4717 6359 5901 5111 3956 4368 5677 4883 5791 4.41_808.56 2360 2549 2825 2968 2785 2439 2903 3111 2606 2474 3010 2818 5135 5208 5175 4717 6359 5901 5111 3956 4368 4656 4883 5791 4.43_599.50 3975 5205 4788 6033 5057 4982 5085 5931 4811 4041 5124 5161 4526 4447 4196 4377 5826 4969 4320 3436 3901 4829 4309 4569 4.50_575.50 7129 7952 7205 9277 7635 7413 7101 8098 7699 6142 7322 7640 5767 5561 4879 5931 7462 6764 4694 4562 4265 5526 5313 5345 4.63_974.58 2750 3431 3755 3301 3021 2991 3277 3415 2812 2296 3027 3635 4161 3944 3660 2663 4043 3140 4675 3602 3153 3873 2925 3158 4.64_802.54 5101 5674 5810 6277 5119 5560 6163 6440 5278 4293 5339 6159 7350 7413 6480 4977 7221 5442 8698 6440 6248 7435 5542 6420 4.65_807.57 11156 12265 15184 14487 13103 13349 15545 16036 13989 11391 13516 15026 10858 10360 9594 8692 12166 9700 12896 9060 9886 11138 8921 9993 4.73_769.56 4786 5003 5530 5245 4914 5173 6274 6412 5099 4498 5307 6224 4607 4427 4056 3500 4126 3503 5627 4205 4637 4480 3954 4428 4.74_784.58 5173 6023 6065 6370 5479 5727 7133 7836 6929 5688 7053 7912 7236 7212 6181 5259 7573 6611 9071 7132 6816 7905 6310 7082 4.76_339.29 3572 4010 4233 4205 3361 3560 3486 3706 3273 3218 3486 3886 9198 9383 8034 6789 9604 7711 10403 6814 7275 9738 7048 8605 4.78_738.51 6874 7474 8471 7504 7363 7724 9151 9613 8029 6999 8368 8898 8196 8932 7607 6272 9071 7393 10326 7768 7606 9988 8341 8363 4.84_726.56 3720 3628 4241 4724 3826 3947 4460 5155 3681 3408 3686 4301 4758 5039 4852 3361 5182 4069 5808 4519 3963 5120 3533 4476 4.88_619.00 3463 3305 3690 3471 3647 3476 3470 3407 3650 3592 3650 3312 3366 3303 3357 3564 3484 3298 3465 3566 3901 3342 3617 3324 4.88_651.53 5528 7471 8083 7201 6853 6933 5852 7775 5781 4833 5907 6025 5394 5444 4987 4476 6816 5316 6420 5308 4783 6943 5902 6333 4.89_1000.60 18260 21077 24648 23254 21553 20854 23467 28277 20236 15451 18745 23625 19810 19720 17084 13062 21474 17634 35157 20023 22482 24233 16006 20759 4.89_714.51 8752 9612 10569 11640 10641 10609 11092 12246 10328 8040 9664 11214 8167 8273 6803 4512 6809 5758 7901 5567 6183 7550 5078 6584 4.91_741.53 3052 3490 3423 3479 2937 3220 3803 4186 3782 3104 3637 3417 4647 4877 4080 3900 5575 4241 5116 4363 3656 4934 3412 4730 4.93_854.57 3419 3858 4637 4620 4600 3990 4502 5104 3771 3409 4614 4300 3879 3842 3617 3631 4512 3882 5025 3728 3601 4385 3314 3789 4.93_794.57 2965 3395 3437 3709 3093 3088 3189 3681 3219 2625 2935 3388 4402 4825 3992 2757 4355 3080 5683 3759 4262 4265 3037 3762 4.93_859.53 6764 7441 7456 8120 7193 6595 6767 7521 6244 6125 6547 6347 7442 6788 5561 5669 8916 7816 6862 5748 5737 6409 6334 6621 4.97_909.55 10636 12123 13716 12445 11429 12577 11990 12638 11475 9374 10403 10090 17050 16230 14689 14167 17400 15111 16311 14118 15667 17843 15621 17503 4.98_809.58 141036 26249 172832 28356 26112 158146 168333 184152 152400 128261 24700 29336 26889 108877 96027 19118 119459 23739 43147 108053 28252 118813 94419 27151 5.00_755.54 12524 13691 15804 14901 14200 13578 15453 16716 13178 10691 12643 14200 11002 11257 9282 5845 9604 8219 12519 9120 8215 9807 7999 9231 5.01_1651.08 4523 4945 5494 5448 4334 4414 4871 5570 4040 2957 4381 4394 4849 4888 3804 2920 5561 3974 6248 3220 4178 5244 4078 5278 5.02_841.62 4195 4852 4233 4162 4181 4316 4471 4264 4154 4441 4497 4584 4122 3907 3835 3755 4750 3934 4895 3988 4327 4504 4085 4089 5.02_958.55 10394 11355 12193 11436 10879 11992 11838 11968 11470 9675 11173 11121 10036 10317 9382 7740 9894 9511 11220 8638 8514 10377 8192 9510 5.02_840.62 6566 6416 7352 6328 6388 6230 6337 6552 6158 6106 6066 6913 5881 6168 5471 4805 6002 5617 6594 5863 6234 6561 5652 5393 5.02_787.51 14012 14413 15376 15289 14233 14066 15996 15910 14399 11528 14260 15305 12125 12748 10763 8603 12436 10563 13415 10391 10557 11834 8872 10612 5.03_623.50 6519 7433 8591 8939 8313 7603 8847 8274 8182 5695 7277 7939 6428 6877 5377 4388 6420 5486 7209 5286 5461 6771 5276 5430 5.03_653.55 4941 5837 6412 5530 5524 5029 4955 5428 5068 4099 5098 4526 2485 2501 2362 2213 2883 2991 2707 2027 2609 3093 2703 2974 5.03_1528.04 6495 7580 9530 8406 7439 8565 8891 9951 7426 5029 6666 7222 5722 5714 4277 3063 5301 4395 6961 4081 4032 5326 3463 4460 5.03_1548.09 5860 6232 8001 7255 5836 6391 7703 8709 6123 3986 5901 6877 3475 3830 3204 2005 3953 3041 5591 2860 3015 4426 2581 3808 5.03_784.82 12534 14537 16808 15028 13586 14264 16173 17255 13837 10564 13018 15861 10509 9889 7843 6207 10564 8662 13714 8556 8287 10488 7953 8882 5.03_862.51 6005 6387 6624 6525 5889 6187 7121 6466 5724 5224 6254 6820 5441 4928 4152 3517 4774 4545 5865 4428 4271 4805 3842 4374 5.04_1588.12 3697 3535 4329 4381 3816 3736 4180 4982 3793 3446 3568 4637 2555 2587 2850 2253 3295 2366 2235 2373 2342 5.07_1566.13 4552 6200 7757 6682 6025 5347 7270 8739 5976 3810 4894 7457 3394 3707 2648 2200 4362 3062 5687 3045 3236 3878 2601 2829 5.07_978.61 29993 33874 37100 33801 31335 22944 36111 38720 33218 27024 32650 35641 19146 24749 21304 17650 23108 21133 30679 20696 23389 27947 19641 23552 5.07_1002.61 17480 19790 21382 21727 19821 19587 20297 21882 19540 14304 18076 20443 13620 12826 11238 9683 15602 12293 18510 12522 13193 14202 11649 12432 5.08_1562.11 5916 6087 7016 6576 5455 5882 6741 7097 5839 4446 5291 6756 5295 5100 4086 3097 5089 4384 7247 4483 4165 5518 3505 4898 5.08_864.56 5204 6065 6198 6637 6068 5794 5489 6510 5464 4085 5570 5109 4103 4142 3652 3461 4538 4154 4412 3164 3622 4699 3649 4192 5.08_1522.08 2816 3387 4064 3427 3696 3459 3932 4519 3455 2209 3434 3469 2867 2804 2308 3601 2519 4726 2332 2310 2964 2350 5.08_880.59 4275 4644 5029 5219 5008 3963 5432 5360 4273 3607 3995 4227 3460 3143 3164 3287 3636 3631 3220 2943 2493 3699 3090 3357 5.10_786.53 29879 32047 37086 31652 32892 34966 37257 40067 34514 27626 28478 36864 27934 26803 23896 18996 54244 24148 32683 43396 23733 28366 20024 41558 5.10_1567.14 3285 3778 5110 4742 4416 3914 4982 5674 3954 2608 3524 4660 3331 3540 2609 3764 3057 5379 3358 2876 3785 2199 2985 5.10_790.54 24508 25641 28781 26291 23913 25090 29286 31544 25167 20816 25888 26164 27347 26711 24073 19957 29941 24573 35042 23948 26298 26624 22110 25883 5.10_811.59 7841 24509 9858 9613 8575 8478 9638 10618 9271 6956 8967 9363 6607 6689 5753 5482 7392 5984 8194 6752 6687 6938 5553 6447 5.10_838.53 12766 13261 13716 13628 12642 12953 13465 13511 13499 11515 13218 13149 21249 13546 14156 11652 14146 20122 13862 14020 12823 21659 12862 12967 5.11_812.54 18646 21326 25195 25208 21417 20647 20446 23185 19434 15458 17507 18278 15291 15004 13443 11763 15863 13694 16065 12127 12585 15392 12734 14850 5.12_1540.12 15458 17962 21303 20151 16897 18141 19914 21853 17299 12079 15791 18095 18515 19324 15908 11498 19660 16032 24568 16351 14758 17880 12547 16312 5.12_184.07 23414 25262 27846 27187 25893 25365 27521 29018 25514 21422 23740 25546 27566 26522 24097 20533 27567 25394 30093 23694 24530 26281 21575 25427 5.12_777.54 3427 3414 3710 3621 4005 3365 4166 4246 3535 2608 2994 3595 3448 4211 3372 2694 4935 3780 5139 3396 3582 3931 3141 3887 5.12_761.58 120633 134138 146189 137188 126473 129670 138650 150104 130587 103988 125695 131811 127257 141795 121758 106262 150390 128133 164460 128604 124641 139889 114578 130199 5.13_398.76 3430 3246 3876 3977 4020 3553 3979 3915 3633 3389 3089 4124 4025 3805 3926 3387 4449 3417 4122 3516 3289 3888 3303 4092 5.13_1159.33 6352 6985 8197 8398 6511 7513 8107 8557 7358 4704 5839 7848 7792 8649 6741 5217 8214 7031 9784 7400 6923 8155 5740 7605 5.13_758.81 286372 313423 344763 324818 304894 312844 332695 358030 313139 247712 293846 318181 331591 333548 291752 252038 346028 301719 388138 303671 299714 330882 270013 304919 5.13_816.62 9260 8742 9470 8415 8863 9679 9010 9101 9783 9484 9225 8981 9488 10022 8929 9104 9852 9153 10063 9044 9729 10129 9433 9407 5.13_1539.12 25811 27497 33374 31028 27382 27892 32966 35905 28551 19627 24409 29403 33324 33964 26164 19996 33670 28213 42101 30099 28041 31729 22268 28995 5.13_840.51 5536 5757 5737 5978 5708 5580 5932 6018 5762 4964 5490 5369 6032 6226 5620 5162 5953 5677 6032 5536 5575 5492 5521 5669 5.13_839.53 6385 6918 7175 6593 6745 6593 6583 6567 6512 5710 6008 6170 6819 6845 6437 5765 6869 6479 6823 7037 6202 6230 5949 6631 5.15_690.51 13003 13544 15265 15279 14753 14620 16137 16840 14845 10640 14561 14519 7951 8208 7068 4295 6727 5958 6250 4869 4788 6163 5232 5215 5.16_1498.09 7708 8383 11908 10211 8611 9625 10733 13176 10083 6374 8647 10059 6988 6936 6192 4229 8111 5564 9942 5404 5223 7628 4705 5568 5.19_599.50 5423 5155 6449 5848 5023 5900 6581 6787 6331 5101 5774 6825 4420 3975 3616 3359 4323 3841 4573 3609 3524 4211 3872 3789 5.19_796.54 10693 11642 23131 11517 19568 20884 11678 12246 10973 16687 19315 21451 11837 12006 10880 9951 11703 10919 11608 10978 10466 11023 9451 11145 5.19_934.55 7414 8212 8999 8723 8085 8394 9289 10448 8961 6891 8443 8488 5967 5973 5119 4034 6149 5124 7099 4663 5123 5678 4200 5304 5.19_740.52 245897 262405 297733 282445 267691 270221 319001 335171 287802 235492 271840 301764 184351 184960 156954 138198 201593 171245 220695 157690 157640 189809 144152 171081 5.19_763.51 9166 9513 10959 10079 9650 10368 12056 12026 11275 8297 10046 11174 7179 7230 5903 5797 7873 6563 8963 5724 6311 8318 5678 6261 5.23_789.54 3958 4252 5429 5293 4282 4536 5081 5394 4802 3716 4491 4403 4102 4080 3522 3363 4788 4222 4686 3384 3706 4299 3598 3737 5.23_788.54 7765 9139 10430 9808 8828 9188 9337 10774 9285 7637 9149 9721 8660 7669 6928 7285 9460 8930 9525 6854 7410 8771 6818 7734 5.24_979.62 9899 12655 16047 13724 12218 12625 15464 18581 13920 8558 12065 14368 10137 10059 8371 7897 12342 10395 14555 9909 10025 11142 7438 8909 5.24_812.58 11438 7259 8730 13552 18426 13085 8650 11961 10789 6904 11514 10719 4070 8563 7651 3470 10375 7485 6960 3909 7607 8325 8473 9376 5.24_766.54 78848 87616 99659 91169 84969 88757 100244 107368 91805 72347 86503 91441 51618 54449 44595 40536 60703 49643 63635 45572 44418 51977 39982 46347 5.25_629.55 8053 10078 10235 10013 9348 9137 8682 10673 8511 6957 7807 8384 11634 11063 10226 9408 12828 11225 11353 9287 9696 13387 10907 13161 5.25_889.58 3709 3754 4203 4088 4356 3414 3852 4385 3354 2959 3203 3021 4585 4555 4220 3794 5320 4009 4648 3664 3742 6024 4468 5399 5.25_810.59 43226 47746 55946 52566 45492 49786 52759 60122 5230 43086 47117 52967 29642 4803 25838 23855 31206 26971 40039 28975 29369 5942 25579 29180 5.27_911.56 3212 3893 4411 3814 4199 3614 3932 4406 3888 2687 3441 3824 4033 3787 3211 2803 4482 3326 3746 2733 3285 4029 3242 3694 5.29_787.59 13041 14079 16456 15626 14268 14246 16906 16437 14910 11997 13406 15952 13429 12687 11174 9012 12865 10528 15031 11388 11595 13395 10750 11704 5.29_575.50 4509 4681 5608 4900 4819 4677 5485 6086 5274 3896 5327 5386 4219 3897 4037 3287 4456 3761 4115 3573 3404 4292 3537 3930 5.29_743.54 5606 6156 18410 6754 15649 6351 6925 20773 6437 5409 6779 19181 19048 4753 17256 17074 4808 20920 5586 15976 15818 18269 15409 17042 5.30_749.54 2402 2573 3125 3105 2784 3098 3195 3852 3117 2627 2664 3322 3327 3405 2923 2606 4004 3501 4590 3046 3522 3629 2805 3091 5.30_748.55 6007 6670 7394 7614 6511 7007 7438 7819 6738 5534 6541 7097 7772 7890 6994 5293 8140 6689 8549 6547 6509 7194 5614 6423 5.30_797.56 9682 9465 5986 11538 5543 6165 10970 13115 9863 4739 5009 5807 7960 7524 7135 6072 8212 6870 9740 7462 7441 8346 6310 8315 5.31_792.58 3504 6490 5273 4425 5879 4427 4688 5310 4069 3605 4080 4747 5504 5477 4607 3839 5486 4611 6536 5605 5295 6011 4459 4929 5.37_742.54 33477 36237 42624 37688 34473 36137 43921 45990 39122 33641 39433 41856 44060 43763 37685 38073 54435 45628 47195 35647 34915 41020 31793 38002 5.37_814.56 2802 3305 3609 3547 3412 3362 2983 3397 2942 2876 3232 2968 4772 4155 4442 4281 5295 4797 5048 3768 4285 5141 4293 4483 5.40_768.58 13225 14529 17004 19168 15262 17109 15803 18259 14045 14204 15175 17448 18301 18754 15999 13481 19140 15766 21684 17533 16973 18513 14990 16602 5.42_744.57 4510 4501 5664 4984 4157 4845 5877 6098 4963 4483 5430 5378 5848 5766 5029 4708 5957 5436 6445 5137 4612 5670 4991 4966 5.43_811.60 22156 24509 28527 25384 22838 24694 27003 30133 25857 20618 23539 27296 13031 12836 11937 10783 15058 12511 17408 13568 13184 14440 11720 12159 5.50_1028.63 4054 4496 5157 5111 4748 5128 5899 6377 4672 3413 4005 4921 3827 4131 3284 2470 3555 2869 5111 3423 3426 3937 3143 3825 5.52_754.55 5452 5725 7231 6581 5556 6207 6892 7050 5797 5391 5701 6150 5170 4677 4251 4250 5039 4346 5891 4363 4302 4701 3993 4454 5.53_754.54 5452 5725 7231 6581 5556 6207 6892 7050 5797 5391 5701 6150 5170 4677 4251 4250 5039 4346 5891 4363 4302 4053 3993 4454 5.53_745.59 2203 2147 2829 2399 2780 2827 2661 2180 2531 2482 3098 2280 2297 2477 2528 2499 5.55_605.55 8314 9925 11098 10897 9502 8850 9739 11306 8910 7543 9899 8874 4629 4298 4427 4618 7098 5171 4495 3567 4064 5362 4838 5340 5.57_928.60 9443 11705 12832 11730 11628 11685 11452 13013 9808 6238 8025 9649 7463 7443 6175 4512 8484 6402 9896 6185 6239 6828 4727 5850 5.57_757.61 5453 6103 7256 6478 5916 5996 6196 6998 5203 4115 4629 5459 5013 5252 4826 3475 4710 4225 5983 4485 4453 4441 3726 4223 5.59_732.57 3068 33255 38820 4390 36558 37099 32643 40360 4440 27997 4159 38447 3867 25124 3174 18357 24629 20447 6556 4820 4776 7866 17957 6471 5.60_770.59 3327 3869 3888 3871 3599 3513 3843 4008 3360 3280 3679 3962 5300 5035 4253 3658 5512 4488 5658 4537 4469 5453 3841 4736 5.60_818.64 7733 8284 8683 8586 8407 8890 8314 9143 8925 6899 8213 8674 6889 6961 6826 5500 7687 6752 9249 6743 7804 7595 6226 6823 5.61_798.59 7289 7268 7843 7168 7185 7126 7478 8103 7853 5777 6071 3801 6176 6525 6102 4965 6776 6005 7449 6284 6143 5996 4981 6236 5.62_730.54 3534 3991 4836 4024 3959 4663 4882 4374 4475 3432 4438 4515 4003 3872 3413 2783 4114 3275 4126 3264 2969 3581 2788 3705 5.62_762.84 11871 12702 16116 14997 12915 13597 14476 16022 13506 10420 12790 15265 10374 11041 9253 7709 11597 9118 15317 10212 10469 11994 8659 10146 5.62_1522.16 4206 4824 6819 6207 5005 5112 5967 7492 4910 2597 4114 5857 3343 3049 2592 3636 2444 6560 2935 2824 3574 2151 2604 5.62_783.57 76883 81476 94922 89782 83318 82260 90801 98019 81648 66145 75213 85718 71788 73769 60784 47153 73802 61100 90479 67061 65785 72742 54515 68410 5.62_978.60 4255 3990 4369 4212 3869 4184 4514 4508 3913 3234 3772 4322 3405 3609 3222 2312 3559 3067 4447 3585 2990 3579 2799 3373 5.62_840.53 7386 7846 8808 8128 8193 7700 8233 8834 6977 5518 6607 7417 6152 6435 5596 4393 6682 5546 7783 6446 6052 6474 4529 5909 5.62_977.60 11845 11516 14171 12928 12309 11542 12896 13777 11465 10333 11747 11573 10883 10565 9032 7155 10927 8805 13719 9804 9133 10202 7376 10685 5.63_957.62 5649 6755 7401 6918 5732 6402 6483 7337 6600 4475 6400 7332 5503 5218 4680 3370 5823 4318 7746 5076 4932 5683 4250 4778 5.64_1552.13 4276 5289 6204 5623 4758 4974 5729 6531 4872 3103 4227 5032 4279 4013 3263 2141 3860 2759 6433 3389 3358 4593 2444 3181 5.64_184.07 14716 15468 18091 16606 14636 15065 16461 16873 14267 12016 14463 15916 12982 14203 11741 9780 13880 13390 15622 11761 13002 14017 11002 12387 5.64_1570.17 4075 4837 7050 5623 5078 4613 5707 7602 4928 3160 4339 5877 3031 3266 2318 3475 2187 6037 2607 2883 3572 2037 2778 5.66_986.58 5473 5972 6764 6489 6087 6092 6338 6478 6361 4843 5530 5616 5722 5644 4851 4001 5188 4635 6798 4724 4870 5834 4211 5427 5.66_792.55 189565 207674 235519 214994 194518 204877 220277 226350 198180 157535 177234 197948 191115 192447 163948 124150 181556 152712 222868 149827 158195 187821 147739 166912 5.67_814.54 16644 17315 19888 18768 15925 18200 18433 18347 17680 13084 14783 16440 15940 16300 13921 11133 15444 13178 18972 12755 13451 15182 12978 14279 5.67_813.61 22161 26159 29191 27382 24752 25889 27050 29360 24519 19714 24600 27765 18275 19564 16890 13273 18887 16766 23661 17728 18429 19488 15583 17137 5.67_1030.64 3334 3509 4134 3938 3402 3660 4281 4217 3965 2887 3483 3832 2272 2367 2129 2715 3318 2297 2225 2804 2028 5.68_769.57 8958 9961 10975 11573 9755 10596 356262 12451 10242 9035 287486 311543 6665 6039 6322 5703 7078 246017 314825 6236 218972 5962 195043 6792 5.71_768.57 19245 20451 23085 23826 20692 656037 709928 712425 636824 515048 21147 632488 13183 544164 13466 12303 14460 13625 14224 13490 11754 535163 426607 12672 5.72_520.51 2740 2778 3638 3390 3387 4724 4447 4979 4043 3533 3780 5195 3427 3582 3239 4426 6362 5700 6636 4990 4742 8091 7017 6968 5.73_538.52 4712 4792 5583 6026 4962 6973 7681 7816 6492 5909 6023 8132 5434 5927 5142 8055 10847 9393 10288 7880 8498 13741 10618 10864 5.79_1595.18 2911 2951 3301 2446 2476 3277 4490 2168 2190 2740 3012 3422 2088 2803 4012 3312 2401 5.79_844.65 3522 3964 4357 4419 4134 3664 4442 5070 4370 3042 3811 4574 4047 4766 3674 2498 4201 3354 4598 3514 3941 4621 3294 4088 5.80_808.58 98198 105452 124831 120971 112542 109234 133196 146042 110453 79707 99563 112244 120065 120772 96582 65793 116610 88322 140035 94601 86253 112301 77234 100166 5.80_824.56 4771 4939 5599 5444 5776 4824 6051 6280 4898 4222 4869 5879 5746 5674 4735 3720 5230 4442 6826 4670 4421 5302 4274 4992 5.81_1486.08 4377 4830 5835 5998 4896 5219 6185 6307 5305 3759 4577 5047 3233 3130 2728 3726 2402 3306 2805 2175 5.84_790.54 44075 47881 52750 51563 47515 50786 54118 54855 46775 38668 45320 48327 43043 43784 36897 32285 44437 37637 49173 35745 35523 42325 31812 39194 5.85_962.58 19559 21302 23626 21964 20394 22974 23506 24066 20858 16105 19043 21614 18886 18821 14209 12648 19307 15751 20122 14599 14727 17298 12178 15777 5.85_627.53 10230 11769 13115 11414 10959 11627 14161 12594 11564 9105 10882 12278 10980 10892 8596 7501 10465 9384 10782 8443 8115 9839 7390 8796 5.86_794.57 29711 32801 37908 34101 33072 34273 36905 38124 34200 26195 30942 33070 19787 20009 16989 13443 20753 16833 22389 16374 17277 24476 15540 17711 5.93_837.62 7927 8500 9454 9229 8468 8647 9534 10072 9140 6451 8324 9380 4093 4033 3928 2749 3917 3646 5298 3697 4036 4512 3610 3729 5.93_1006.64 3701 3970 5268 4929 4372 4310 5295 6133 4463 3341 4316 4977 4427 4041 3587 2274 3677 3510 5348 3198 2969 4084 2979 3746 5.93_835.60 3284 3632 4427 4531 4377 4420 5097 5143 4028 2995 4247 4084 3874 3705 3052 2374 3181 2944 4478 2972 2899 3873 3251 3441 5.94_938.58 3453 3662 4860 4147 4003 4332 4782 5175 4213 3396 4055 4726 3869 3606 2892 2655 3762 3044 3804 2786 2771 3309 2815 3112 5.95_815.63 4248 4225 5063 4706 4387 4362 4796 5272 4380 3894 3855 5076 4626 4570 3955 2787 4143 3726 5111 3716 3842 4974 3815 4063 5.95_603.53 3794 3909 4559 4707 4628 4341 4676 5271 4106 3406 4022 4542 3944 4051 3315 3008 3867 3392 3768 3398 3021 3931 2998 3740 5.96_776.58 4362 4534 5095 4965 4372 4772 5248 5309 4586 4257 4886 5265 4375 4619 4024 3817 5337 4177 5742 4383 4731 4643 3432 3852 5.99_747.60 5263 5775 5961 6886 5381 6498 6094 6601 5687 5077 5746 6084 8120 7807 7980 6418 9320 7827 9845 8496 7901 8473 7001 7735 6.12_772.61 3294 3384 3712 3826 3323 3602 3538 3750 3190 2820 3284 3606 4217 4423 3938 3507 4647 4229 5216 4282 4279 4682 3834 4102 6.12_770.57 17461 18579 21879 20138 19496 19393 21173 21107 19310 17025 18987 18710 23012 24456 20985 17053 22479 20028 25119 18487 18728 21471 17883 20804 6.28_982.64 4567 4535 5595 5208 4872 4857 5597 6020 5319 4642 5097 5736 4903 4566 4389 3274 4724 3856 6505 4772 4599 4864 3901 4338 6.32_796.59 9626 9953 11844 11256 9519 10592 11705 11375 10244 8723 9779 10389 4852 4889 4623 3667 4840 4485 6211 4272 4680 4786 4195 4247 6.37_639.50 4607 4488 5417 4876 4350 5352 5518 5153 4364 4431 4818 5039 2437 2577 2533 2195 3478 3051 2755 2195 2104 3522 2556 2921 6.50_631.47 5837 5909 6450 5912 6194 6273 7450 7532 6462 6283 6286 6587 3330 3939 3227 2723 3307 3763 4207 3286 3203 4007 3031 3748 7.02_758.22 7016 47972 5913 20314 2034 12609 7723 26069 13715 2182 7.04_633.49 4928 4846 4859 4787 4996 5001 5626 5330 4909 4720 5112 5044 2659 2952 2334 2068 2012 2719 2641 2391 2303 2143 2798 7.05_1212.03 8368 8605 10071 9273 9261 9389 11778 11482 9782 9138 9889 10168 2014 2211 2790 2561 7.13_659.50 3865 3680 5098 3486 3497 4112 4248 4468 3598 3520 4012 3497 2582 2703 2106 2079 2012 2863 2265 2082 2225 2054 2519 7.16_668.59 2024 2057 2365 2697 2653 2858 2820 2682 2354 2948 2579 2706 3475 3216 2844 3272 4441 4077 5444 3889 4294 5112 4441 4789 7.21_646.61 2384 2329 2337 2680 2398 2946 3027 3288 2476 2313 2534 3205 3951 3361 3377 3593 5395 4637 5897 4394 4528 6255 5151 5354 7.46_548.46 2053 2086 2229 2252 2194 2212 2011 5110 4944 5047 3539 3853 3795 6039 4978 5732 5779 5192 5137 7.56_267.21 2442 2726 2676 2749 2876 3129 2920 2962 2607 2258 2714 2210 4770 4937 4544 3144 3915 3394 6165 4584 5099 5590 4664 5044 7.56_680.58 3321 3669 4229 4070 3960 4151 4588 4647 4427 3517 3934 3898 3274 3960 3129 2714 2219 2533 7.61_832.24 6440 37365 5599 16574 2573 9156 7103 19884 10274 2200 7.66_536.44 7815 8134 8593 7573 7958 6931 8217 8270 8009 7222 8219 7187 14360 14459 12269 9848 12264 11960 13048 9998 9674 13989 9838 11786 7.77_842.66 2907 2922 3132 3189 2936 3623 3651 4355 3235 3042 3040 3740 3835 4062 3514 4176 5824 5003 6403 4567 4913 7334 5590 6258 8.00_524.46 8821 9013 8468 8700 8553 9354 9429 8963 9227 8085 8803 8122 12566 13110 12424 11198 12547 12214 12716 12985 13862 12912 12714 11957 8.03_199.15 4110 3431 3140 2650 3548 3092 4816 3166 3401 4996 3517 3699 8.03_95.09 2025 2494 2576 2741 2695 2403 2786 2809 2759 2734 2354 9397 9660 8857 4740 7030 6462 12142 8271 9158 10223 9130 9407 8.03_145.10 5142 4973 4906 2799 3541 3482 6807 4538 4890 5370 4922 5024 8.03_175.15 3403 3856 3446 2223 2850 2993 4297 3493 3759 3981 3218 3383 8.03_81.07 4141 3694 3373 2007 3047 2613 4625 3244 3088 4453 3142 3965 8.03_119.09 2458 2776 2763 2850 2761 2968 2512 2530 2960 2359 2676 2387 6784 7169 6232 4292 5348 5076 8100 6001 6197 7280 5614 6313 8.03_189.16 2186 2112 6210 6395 5349 3489 4957 4293 8191 4928 5901 6660 5255 6050 8.04_269.23 82443 86620 96050 91198 89593 95870 100777 89147 93735 69658 82983 79325 424983 416539 375268 206835 302472 256728 542360 347902 383285 475880 361437 405126 8.04_213.16 4394 4915 4713 2651 3331 3022 6288 4282 4466 5171 3965 3989 8.08_682.60 9370 10527 11306 12438 12189 12617 12888 12035 12266 7736 9893 8999 3320 3976 3169 2407 2004 2183 8.10_550.47 3063 3200 3741 3429 3222 3210 3397 3397 3281 2685 3265 3098 4785 4613 4401 3629 3769 3846 5417 5044 5041 5497 5263 4514 8.44_844.67 3959 4537 4577 4366 4570 5095 4767 5122 4730 3722 4361 4988 4570 4944 4133 3982 5543 4552 6512 4476 5300 7082 5449 5559 8.52_536.44 3798 4295 4943 4546 3930 3969 4269 4406 4320 3907 4566 4229 27018 26191 23382 20841 26427 24688 23927 18879 18900 25904 19838 22581 8.60_980.28 4953 24878 4049 11865 4114 6547 5665 2014 14193 7611 8.72_269.23 13025 13918 16128 15742 15700 17334 15255 15268 15157 12651 14484 13051 40005 38698 36254 20327 27476 25131 51162 35557 40023 43412 34983 38302 8.72_552.49 3010 3388 3462 3372 3081 3277 3080 3391 3335 2782 3204 3171 6137 5773 5573 4066 5133 4555 7053 5527 6358 6891 5523 5845 9.08_712.64 6871 7667 7612 7785 7451 7819 9097 7755 8598 6071 6012 6266 9.09_1423.96 4003 4781 6217 5107 4788 4053 4621 4703 4537 3411 4564 4604 2981 2963 2742 2781 3862 3235 3454 2215 2285 3030 2664 2849 9.10_780.71 7944 8940 9906 9557 8072 9012 10138 9060 8972 6138 7261 7596 9.15_599.50 6542 7750 11519 8621 7494 6901 8013 7524 7745 6531 8060 7382 8505 9416 8049 7438 14519 11309 10133 6146 7641 10385 7652 9131 9.15_1451.99 7047 8381 11212 8368 8135 7420 8340 7867 7426 5741 7562 7538 8859 9899 8568 8174 14009 11369 11181 6621 7397 10667 7801 9783 9.15_1472.96 3237 3964 5436 4331 4053 3422 3834 4253 3630 2967 3853 4055 4377 4910 3978 3782 6420 5218 6078 3114 3653 4858 3946 5055 9.16_846.75 11067 12905 12540 12471 11693 12421 14249 12306 12605 8978 9973 10339 2338 2253 2009 9.17_806.72 12528 12828 14282 13299 12300 12986 14487 12944 12892 9201 10502 10939 2118 2038 9.23_872.77 9135 9759 10807 9989 9509 9662 11182 9814 9816 6826 8343 8418 2183 2263 2156 9.23_832.74 9794 10454 11344 10876 9431 10280 11859 9930 10334 7398 8888 9314 2215 2479 2160 9.31_858.75 8757 9375 9866 9287 8542 8939 10277 8720 9030 6639 7549 8632 3187 3199 3097 2077 2177 2200 2929 2356 2433 9.34_822.67 7094 12334 7523 7746 11728 7035 8650 7231 6928 5921 6611 5937 2846 3286 2569 2188 2329 2175 2248 9.35_821.70 12747 22937 13609 23122 5040 12147 24551 5194 12114 9497 10448 19138 4572 5363 4593 2430 2503 3485 2983 3060 3875 2886 3780 9.38_898.78 8001 72576 9119 8636 67541 8707 9582 8163 8670 6134 7072 7260 2904 3051 2971 2393 2587 2528 9.39_884.77 6686 7492 6890 7327 7487 7202 7574 6628 6961 5019 5467 6279 2918 3197 2805 2574 2018 2896 2316 2413 9.46_950.82 4579 5453 6350 5885 5327 5665 6625 4980 5300 4209 4892 4772 3511 3985 3641 2255 2805 2166 2484 3237 2808 2819 9.48_1453.00 4291 4986 6322 4750 4657 4513 5250 5157 4653 3658 4311 4385 4666 4948 4931 3991 6798 5945 5396 3763 4165 5500 4636 5363 9.49_910.78 6350 6288 6781 6742 6085 6506 6466 6237 6316 4770 5259 5422 4319 4504 4049 2414 3256 3075 3708 2919 3233 4089 3205 3582 9.50_924.79 5780 6267 6509 6468 6001 7196 7109 6227 6637 5286 5788 5611 5918 5709 5405 4519 5588 4915 5798 4641 4600 5560 4690 4862 9.53_936.80 6154 6885 6568 6192 6230 6102 6542 6243 6186 4855 5552 5394 5802 6399 5251 2952 3534 3173 5464 3888 4686 6089 5227 4936 9.53_976.83 4718 5026 5560 5224 5069 5262 4750 4829 5041 3672 4660 4278 5085 5609 4446 2317 2886 2550 4199 3765 4065 4453 3545 4391 9.53_894.75 19928 22226 22940 22784 20567 21645 22451 20252 20853 16158 17778 18323 20842 21354 18502 8196 11679 9621 18831 12364 14702 17980 14461 16462 9.55_873.74 5309 9232 25971 24151 23635 25210 10322 6271 6031 18549 20221 21758 6505 6705 5466 2508 3196 3073 5182 3795 4290 4989 3931 5328 9.55_1058.72 2798 2884 2859 3195 2939 2616 3375 3225 2939 2326 2742 2746 3818 3730 3661 2703 4142 3619 3784 3334 2981 4363 2872 3810 9.55_908.74 9838 10908 10815 12028 10291 10890 10145 9857 9956 8890 11103 10058 14319 15389 12012 11157 15227 13384 13302 10942 10423 13859 11153 12496 9.55_962.80 9069 9706 10536 9939 9040 9781 9031 8616 8885 8009 9014 9118 13627 12818 12099 10095 13382 11944 12389 9664 9848 12091 10995 11774 9.55_848.71 30903 45894 41193 24140 43734 35712 37742 39597 40542 31498 5057 5294 2797 6521 6066 2377 2793 2745 2316 2005 2441 2633 2144 9.55_907.73 9132 10450 10893 10406 10232 9869 9157 9468 9559 8557 9032 9140 12706 13588 11630 10764 13500 12570 12490 9894 9682 12336 10339 11184 9.55_864.70 11764 13888 13789 13970 12310 12963 13048 11478 12928 10239 11726 11276 15097 14537 13867 11758 16178 13217 15023 10840 11765 14093 12279 13056 9.56_899.72 9221 9449 9122 9244 9485 8363 10426 8991 24548 6970 21970 7752 9221 9260 8762 3725 5072 4700 7635 5761 6371 7349 6246 7129 9.59_917.69 6149 6957 6385 6343 6708 6620 7632 6254 7263 4749 5726 5543 2031 2359 9.59_921.76 5128 16319 5446 5634 15806 16286 5099 5129 4621 4298 5200 4743 6269 6376 5593 4211 5153 4895 5768 4765 4526 5461 4576 5197 9.60_922.77 72246 18373 19016 18623 18752 18618 17112 20265 17525 14778 16996 16628 23245 22928 19901 16722 23166 20894 22923 17047 17070 22018 18932 19089 9.60_923.77 11136 13115 13367 12265 12800 50868 11820 55882 12493 10211 11644 10955 16389 15080 13021 11006 15011 13731 13771 11452 11632 14646 11879 13890 9.61_822.75 12822 14101 13777 13254 15480 13668 15980 13142 15205 10419 11662 11051 2436 2315 2120 9.61_874.73 33563 63762 6235 5933 62599 61437 68018 61487 61782 45866 13278 4849 3750 13774 12590 6839 5947 3574 3949 2389 9854 7897 8556 9.62_943.70 21148 22571 24575 23622 23018 23653 24937 21823 22337 17352 18519 18716 3542 3206 2762 2081 2336 2041 2336 9.63_767.70 102433 111825 115685 116422 111100 112696 132082 107339 115733 71991 85845 89337 9361 9931 8435 3960 4989 4296 4110 3613 4448 6291 5445 5846 9.63_808.74 44249 46865 48831 47430 46585 49030 52672 44883 47478 35195 40441 40349 6185 5693 5507 2477 3347 2769 3050 2757 2572 3859 3218 3689 9.63_848.77 42639 46090 48086 47656 43944 47365 50577 43928 46480 33387 39156 39945 6202 6521 6066 2891 3285 2912 2842 2428 3072 4265 3814 3685 9.65_795.72 15357 16716 17786 16306 16409 16857 18669 16966 17232 11594 14146 14232 2320 2372 2121 9.67_798.67 35307 34453 36705 36325 34813 34231 40199 34321 33505 28354 30294 30609 8037 8371 7496 3159 4387 4133 4402 4472 4110 5682 4664 6037 9.67_834.75 65556 69473 71939 70519 66659 70549 74789 69263 70957 51979 58064 61880 13289 13224 12739 5253 7181 5829 7674 6632 6677 9490 8928 8859 9.68_874.78 61140 63762 66881 62465 62599 62053 69966 61487 65797 45866 53083 55084 13689 13774 12590 5283 6839 5947 7413 6232 7185 9854 7897 8556 9.70_1599.36 7190 7607 8087 7891 7313 7100 8621 7464 6561 5694 6362 6294 9.70_821.73 20561 22937 23445 23122 21531 22332 24551 20163 22766 16320 19218 19138 5199 5148 4842 2174 2945 2376 3171 2621 2988 4053 3229 3999 9.72_900.79 56726 63486 62678 63383 60515 60245 68613 60013 5439 47862 55185 56290 21187 22572 20927 8643 11649 10052 13957 10739 12303 17116 13977 15171 9.72_839.65 11523 12024 11583 12270 11339 11283 12712 11509 11589 10323 10468 11314 6705 6535 5679 2572 3626 3802 4475 3699 3796 4230 4232 5018 9.73_861.77 38876 41893 42805 40666 39171 41493 44345 40384 40923 30210 34444 36579 13534 13912 11838 5570 7315 6211 9014 6774 7948 11252 9118 9943 9.73_860.77 64837 70947 72771 72422 66780 69724 75797 67231 71586 53427 61491 62880 22963 23143 21112 9233 12333 9921 14827 11602 12858 18605 15319 16239 9.73_862.77 14814 16553 16404 16072 15284 15137 16573 14797 15653 12509 13685 13975 5071 5432 4740 2575 2739 2529 3761 2694 2745 4084 3482 3736 9.74_859.75 5566 6206 6366 6300 6001 6254 6520 6248 6510 5149 5489 5506 2682 2883 2854 2122 2080 2078 2024 9.75_847.75 20224 21890 22889 21040 21850 21570 23196 21690 22080 16215 18721 19701 8437 8397 7113 3299 4627 3865 6371 4125 4972 7211 5500 6399 9.78_895.76 10372 11139 12574 10993 10413 11219 12813 12096 12139 9772 12118 11373 8954 8880 7839 4107 6122 5021 8555 5738 6551 9287 6824 7848 9.78_849.72 72164 73943 76517 78888 76878 72880 81507 26652 72113 57420 22878 64279 41052 41539 37141 15224 21009 20714 30041 23487 25863 34010 27027 31681 9.80_886.78 59069 64426 65906 66529 62091 64011 66806 61917 63369 48445 55090 57915 31780 34169 30533 12742 17239 14591 24053 19395 20551 28887 23060 24628 9.80_850.73 41841 42685 42346 45530 8937 43829 46936 41296 40248 33349 38321 37262 22893 24814 21826 9623 12461 11288 17706 13874 14416 19561 15811 18863 9.81_944.77 4153 4997 4811 13594 4160 4144 6370 5135 5449 4939 6100 5573 3867 3503 3415 2615 2272 3751 2664 2902 4396 3811 4157 9.84_926.82 51917 53608 55316 105273 54200 53014 56235 51519 52814 40526 46351 46774 28503 29090 25319 11098 15392 13285 21079 16359 18560 25392 20842 22896 9.85_873.76 22457 23703 25971 24151 23635 25210 26365 24243 25040 18549 20221 21758 13391 14022 12461 5104 7184 6178 10415 7612 9863 11916 9578 10467 9.85_899.77 4995 25937 26184 24793 5107 25526 26488 24215 5361 19275 4323 21667 20164 19972 18902 7896 11948 9724 16347 15792 15714 17476 15047 20772 9.86_875.74 36967 77637 39634 82337 77849 75180 82753 36721 76162 65407 188904 69525 62190 62532 55455 25763 34690 30420 49097 39543 41384 51131 40124 47887 9.87_912.80 59601 65724 66759 66218 64072 66397 67448 64150 63793 54624 57754 59024 47546 49902 43995 20120 27563 22921 39694 29787 33909 43840 35773 38622 9.87_780.71 22773 24411 25961 25047 24366 24780 28349 24045 26083 17566 19853 20108 3782 4251 3394 2134 2353 2554 2491 2391 2079 2832 2918 2723 9.87_952.83 51117 53969 54186 55019 51045 55577 58449 53222 52977 45451 47379 49978 41143 41583 37128 17602 24072 20288 33313 26337 29370 37604 29602 34127 9.87_891.69 11911 11406 11811 12694 11185 10968 11616 11687 10665 10715 10477 11200 10934 10845 10016 5629 7069 7078 9379 8487 8679 8787 7672 9504 9.91_806.72 32805 37887 39392 37202 34909 36222 41718 33790 39086 26191 30446 31281 6790 7364 5971 3019 4277 3537 4612 3736 4137 5571 4299 4897 9.91_938.82 35433 40011 40220 39658 34974 38998 39895 36905 37206 31353 34344 33482 42479 40840 37629 19367 27050 23346 36598 28815 31780 37412 31423 33878 9.91_889.79 8780 9476 10392 9482 9464 9357 10869 9414 9536 7754 9015 8822 4720 5124 4265 2111 3052 2425 3814 3017 2981 3982 3261 3613 9.91_1073.77 16266 17139 17109 17061 15189 16124 16444 15797 15704 14240 14907 14677 18398 18809 16732 9427 12409 10567 16952 12247 14485 15685 13359 14480 9.92_915.81 7710 8261 8481 9082 8474 8784 8982 8262 8520 6824 7520 7661 5132 4953 4473 2623 3234 2848 4171 3053 3595 4270 3609 4358 9.92_917.70 7912 7825 8182 8286 7799 7638 7822 7837 7086 7149 6967 6553 9287 9845 8555 5833 7119 6850 8298 7767 7915 8171 6851 8327 9.92_978.85 30882 31426 32622 30798 27926 31738 32802 29958 29699 25209 27675 28199 33660 33967 30545 16559 22564 18999 30362 23066 12604 31066 24893 28701 9.95_1074.78 11004 11170 12023 11219 11154 10978 11713 10444 11126 9662 10423 10003 10623 12615 4339 6433 3906 7631 5330 8434 9725 5251 9448 4430 9.96_1002.85 4075 4210 4537 4211 3682 4246 5887 4967 4748 5284 6116 5396 6931 6598 6349 3856 5070 4327 8125 5536 5972 8434 6576 6586 9.96_962.82 5224 5127 5661 5107 5347 5368 6544 6163 6640 6756 7245 6908 7956 7834 6985 4824 6426 5155 10329 6804 7694 9635 7364 8582 9.96_941.70 2052 2148 2332 2182 2141 2354 2237 3068 3255 2875 2223 2661 2477 4000 2810 2970 3319 2917 4238 9.96_947.78 7658 8047 8261 7951 7033 7458 9493 9693 9076 8725 9333 8847 11554 11924 9631 6354 8582 7350 13318 8799 9496 11838 9531 10125 9.98_951.75 3329 3455 3246 3012 3153 3197 3903 3859 3154 3896 3624 3420 5105 5477 3811 3186 3745 3696 5981 4547 4420 4358 4055 4660 9.99_946.77 8315 7876 8027 8300 10369 9517 9348 8748 10319 8817 10272 9282 11338 11314 10099 6168 8936 7265 13072 8738 9753 11454 8833 9887 10.00_811.69 6388 7091 6823 6876 18555 6655 7543 6853 7365 5512 6124 11817 4011 3864 3540 2643 2170 2049 2613 3222 2548 10.02_1035.76 3205 3764 3904 3867 3655 4194 3818 4066 3472 3002 3240 2933 2768 2769 2155 2379 2322 2139 10.03_941.83 5519 61803 6256 5926 5496 5536 6566 5604 5456 4663 5275 5004 4007 3889 3462 2474 2229 3469 2667 2814 3842 2700 3191 10.07_773.66 16365 16514 13269 13943 20815 17695 18920 14009 20627 12134 15844 13250 4253 4719 4456 2061 3341 2630 2510 2415 2314 3562 3969 3339 10.07_811.75 14343 14806 12619 13135 18555 16441 15805 12501 18379 10994 14655 11817 4011 3864 3540 2643 2170 2049 2613 3222 2548 10.08_815.65 11823 12446 12218 12059 11256 11968 12706 11933 11410 10351 11216 10822 4879 4720 4620 2253 2828 3202 3023 2659 2386 3269 2949 3377 10.08_1577.37 21502 21085 21920 22509 23018 22232 25452 21234 22740 16418 19576 17784 2943 3325 2752 10.09_810.75 26799 26073 22348 22247 32087 29913 28571 22487 33272 18227 26354 20901 5642 6147 6452 3295 4857 3260 3230 3051 3332 4568 5493 4445 10.10_768.71 206284 215317 170548 180065 301804 264191 249407 189127 309654 133042 208026 152549 26507 28485 27473 9822 16772 10991 11534 9230 10385 17005 20449 16108 10.10_836.77 130247 144258 143640 138385 140811 142636 151633 135725 139920 110767 126067 125670 32404 33214 30618 15665 19176 15639 17082 15268 15762 23319 19510 20975 10.11_901.79 36481 39628 128577 125023 117616 121867 122692 36372 116532 111066 32432 114399 119827 123178 12139 5429 7346 72853 111017 6779 95047 109504 91688 102130 10.11_945.71 13129 13366 11179 11431 17137 14943 14677 12853 17481 9892 13961 10402 3803 4060 3808 2071 2702 2533 2896 2204 2356 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76724 64017 69897 10.53_825.01 27496 26796 27758 28198 29976 30318 31178 27294 30851 22763 26333 25184 5864 5963 5293 2096 10.53_999.76 120076 124741 126333 124358 125790 129400 136425 123063 127765 107130 118946 116159 42728 42684 41166 20435 26607 23525 25381 22814 24471 32577 27595 31440 10.53_1659.45 60281 62725 61377 62069 61420 62365 66854 60342 59386 57056 56767 58804 21519 22288 20873 9075 11753 10683 11694 10569 10948 15558 13424 15179 10.53_1660.45 35630 34080 35639 36757 35065 37387 39387 35103 34327 33462 32403 33190 12350 12421 12454 5539 7034 6196 6602 6011 6363 9683 7801 8767 10.53_974.75 7203 6190 4301 5056 11930 9279 6480 5561 12718 4603 9408 4186 3406 3898 4601 2450 4315 2526 2697 2715 2633 3381 5936 3198 10.53_977.81 2349 2568 2909 2663 2621 2478 2645 24897 2616 2320 2365 4056 2032 2759 2403 2259 2173 2765 2123 4480 5103 2343 2436 10.54_1047.75 9776 9554 9470 9509 8968 8946 9148 9447 8190 10217 10069 9724 12793 12977 12759 10704 11572 10696 11661 11566 11464 11559 11036 12724 10.54_1661.46 13332 13682 14542 14682 13753 14198 14891 14787 13642 12120 13544 13293 5281 5383 5160 2444 2986 2814 2733 2711 2933 3852 3631 3685 10.54_1658.45 49938 50371 52889 51569 52407 54771 55829 53403 51461 46862 46855 49592 18848 18307 17300 8021 9820 8749 9606 9070 9594 13888 12005 12902 10.54_523.47 22588 22643 21699 22899 28546 26483 25478 22476 30007 20113 24176 19557 8540 8990 9124 3816 6524 4631 5219 4952 4632 6509 8658 6660 10.54_826.77 19713 19945 19652 19955 21876 21781 21344 19899 21950 17656 19952 18403 6667 7232 7354 2742 5283 3049 4070 3311 3645 4596 6284 4862 10.54_968.86 14251 16374 16716 16238 14484 15923 16118 15516 15224 13725 15184 13867 13770 13984 11586 10159 11464 7893 15876 10012 10727 12804 9935 12595 10.55_869.70 18268 16741 18606 18349 16730 18264 17440 18608 17376 18252 17735 18572 15184 14764 14249 10811 11717 11763 13232 12224 12680 13052 12992 13908 10.55_933.85 12332 13056 13553 12794 11699 13454 12814 13243 11839 13515 12873 12770 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3510 3670 3522 3074 4237 3329 4175 2768 2830 2391 2150 2134 2411 2450 2733 2077 2214 11.72_988.93 49451 54011 52764 48502 50287 51826 56385 42498 48251 49185 49839 45983 20167 22085 19978 13656 16162 14696 17328 13744 14988 18479 16649 15783 11.72_853.81 630601 437484 98891 279947 1100390 905039 336110 482734 1145091 127790 843771 83923 18255 47984 149545 53321 219361 61698 71906 61960 73934 79175 276409 84621 11.73_948.90 61734 60878 57234 57181 64790 63414 67405 52392 60670 55775 60552 50180 22274 24315 22567 13165 17912 15239 19061 14818 16291 20048 18222 18655 11.73_984.90 7318 7296 7558 6930 6902 6604 6904 6840 6437 5809 6455 6203 3543 3859 3396 2135 3030 2849 3304 2572 2680 3196 2800 2986 11.76_908.86 129392 110646 87384 107983 189722 178126 144796 123801 194952 78020 152238 77286 19997 25544 29357 13322 31494 15340 18412 13437 16348 20429 35202 19099 11.83_947.89 7853 8066 8802 8336 8307 8554 9147 8088 7998 7063 7937 7620 3707 3774 3654 2773 3234 2709 2996 2421 2421 3124 2839 3111 11.90_1002.94 7286 8925 11106 8943 6691 7073 7981 7174 6000 9385 6857 9974 4120 4425 3875 2597 3579 3508 3675 2475 2904 3544 3264 3420 11.91_1042.98 5130 6462 8559 6967 3839 4361 5886 4812 3206 7318 4761 7519 4005 3602 3272 2292 2610 2437 3041 2205 2593 3166 2428 2974 11.92_920.87 35741 24820 19756 28402 57354 51154 44190 42650 59908 19299 39510 17210 2592 8057 10148 4995 8763 5937 5261 5263 5971 6291 9851 7010 11.92_1157.05 11264 11511 10763 11911 9932 10367 12367 10511 9828 10109 10379 9474 11.96_880.83 370469 242325 65378 165332 577788 527245 204236 296905 621402 74656 488110 73030 5919 23267 86152 18791 94921 20838 22475 20093 25391 23185 116898 31543 11.96_1131.03 12284 11832 11941 13139 12536 12817 15542 12501 13308 10682 13520 11280 2620 2734 2503 2041 2544 2394 2366 11.98_1047.91 2017 2673 2599 2179 2011 2605 2510 2144 2066 2104 2180 7870 7580 6910 3612 6001 5085 6369 4324 4947 6864 5763 5971 11.98_1089.94 3766 2050 3050 4647 3499 5835 13647 13757 6597 8976 3310 4893 8190 9874 13281 3551 4085 11.99_1137.92 2402 2980 3925 2954 2881 2162 3197 2150 3473 4977 4784 2439 2858 4131 3454 3452 3552 4230 3713 12.00_1241.94 5989 6575 5331 3254 3734 4104 4953 3751 3779 5584 4258 5103 12.00_906.85 173109 272298 100538 105797 851349 241951 144064 205095 277096 54659 206048 27544 3468 10846 23633 5931 25325 5914 6432 6224 13897 5439 29663 12406 12.02_989.93 26517 26700 27993 27792 35397 26426 33082 28465 23648 24308 26468 24486 9447 8855 9152 6113 8477 7438 8375 6540 6808 8145 8304 7989 12.02_1105.99 4347 4574 4005 4951 5749 5465 5691 4711 7021 3735 5699 3946 4274 9403 7756 4622 6364 5535 3932 5581 6041 8219 6419 7282 12.02_1030.97 4083 4844 5479 4125 3409 3792 4430 4055 3302 5151 3842 5534 2094 2416 2158 2440 2207 2004 2242 2194 2073 12.03_1105.00 6009 6017 5395 6428 7773 8004 7526 6314 8754 4733 7913 5231 4823 11405 11003 5926 8425 6708 9831 7182 7544 10781 8348 9232 12.03_1016.96 6141 6698 7442 6655 5105 5978 7175 7843 5268 7368 5930 8159 3964 3669 3440 3313 3939 3638 3130 2929 2956 2968 3252 3410 12.03_1044.99 3541 4400 5372 4796 3204 3112 4305 3173 2716 5234 3011 6069 2112 2393 2549 2033 2401 2132 2055 12.03_1004.96 5088 5501 6308 6677 4578 5027 6427 4732 4714 6449 4948 6562 2773 3379 2848 2818 2974 2339 2316 2192 2205 2736 2926 2720 12.05_1076.95 6951 9546 9618 7083 5577 5777 8354 7892 6696 7800 6747 7755 36921 35577 32817 17999 24438 21358 28992 19430 21142 30424 24056 26660 12.05_1062.92 2437 2308 2053 2226 7694 6894 7051 3558 4810 4043 6129 4709 4578 6672 5445 6163 12.06_1114.95 2384 3160 2974 2482 2294 3196 2749 2359 2560 2432 2635 10667 10860 10089 4296 6739 5716 10015 6821 7192 9142 7984 8000 12.06_864.81 23814 16387 6846 16369 49123 38775 27459 29736 44387 6964 26201 5952 2021 2340 3839 4300 3169 3359 2008 2663 4209 3254 12.06_899.79 2282 2968 2947 2947 3020 2461 3145 2867 2884 2606 2670 2825 5813 5296 4911 3480 4358 3894 4504 3943 3834 5104 3929 4762 12.06_873.77 4171 4157 3897 3786 4112 4282 4032 4657 4311 3552 4324 4133 8699 8457 6955 5114 7263 5409 6520 4946 5534 7132 6485 7095 12.06_871.76 2818 3168 2734 2783 3022 3188 3738 3266 3518 2470 3135 2202 7977 8031 7075 4521 6316 5270 6442 4529 4652 7096 5983 6342 12.06_1159.02 4687 4844 5177 5180 4835 4957 6514 5112 5585 4819 5158 4444 7476 6291 6278 3948 4627 4203 6844 4731 4744 6459 4787 5376 12.06_1049.93 22633 25722 28266 25091 14998 20500 31855 28314 20975 26488 25062 28545 134274 127397 112578 63800 93124 77225 98701 66487 73161 106783 83830 96653 12.06_1166.08 10939 12146 13161 8843 5994 6950 9728 8085 5778 9286 7689 10422 5737 4389 3746 3786 5424 5072 4913 4467 4158 5933 4154 3688 12.06_1243.96 7020 8541 12385 9437 4479 5312 10746 8027 5532 12131 7558 14498 50674 47172 42035 29670 37742 35114 39843 30746 30604 43764 34126 39052 12.06_177.16 6330 6998 8115 6736 4486 5647 8475 7283 5906 7415 6504 7856 32964 30664 29588 17409 23066 21133 27450 18396 20407 29473 23124 24298 12.07_1160.05 3787 4521 4036 4469 3867 4033 5287 4530 4421 3463 4331 3547 6034 5567 5561 3286 3873 3420 5162 3723 4143 5406 3962 4676 12.07_1195.12 4118 5473 6928 4564 2569 2822 4463 4029 2633 5526 3588 5198 13601 14345 12065 10961 14272 13087 13809 9366 9574 13202 9455 11362 12.07_1097.95 6280 6649 7284 6576 4055 5199 8285 5186 5536 7226 5724 6917 15762 15507 13214 9244 10797 9987 12842 9039 10319 13070 9832 11912 12.08_1072.92 3720 4190 5856 4743 2398 2537 5099 4636 2477 5337 3792 5347 21165 20529 18044 6760 8828 15124 17093 12917 13148 9818 13992 8542 12.08_1133.01 4580 5396 6815 5437 4886 4471 6049 5096 5090 6442 4658 6749 26455 25406 25955 9779 13997 12599 25169 13091 18469 24086 17875 22833 12.08_1075.94 7994 9771 9587 9513 5836 7039 6264 9568 6955 8956 8192 8880 45738 44039 37345 21641 30231 26466 35222 24258 25853 39158 30688 33623 12.08_1199.05 2292 3979 3817 4495 2877 3300 3240 4692 3756 3590 4961 3504 4464 12.08_1173.03 3051 3821 4984 3821 2869 4036 3462 2550 4610 2789 5089 21175 20863 18894 8682 10151 10173 18736 10549 10812 18636 10949 17659 12.09_1050.93 7673 8045 8232 19836 12898 17416 25198 22544 17688 8533 8564 21873 103827 102251 88770 50647 72890 61109 78070 51803 60137 86950 64767 74449 12.09_1063.93 2243 2212 2179 2076 2538 2479 2648 2181 2753 7642 7937 7088 3954 5995 5348 6220 4181 4464 6756 5322 5634 12.09_1104.98 2952 6017 5395 3334 7773 3221 3852 6314 5982 2912 3711 2971 11932 11405 4772 5926 8425 6708 9831 7182 7544 10781 8348 9232 12.09_1269.97 3636 3793 5652 3974 2091 2775 4435 3668 3043 4886 3154 5621 21871 21797 19759 13631 16621 14927 19689 14946 15993 20137 15929 18785 12.09_1244.96 6407 7472 11735 8463 3890 5383 9076 7566 5645 10957 6528 9282 43215 40318 35971 26050 31720 29447 33377 25802 29011 36773 28531 32403 12.10_1017.96 5569 6411 6934 6315 4494 4887 6033 5236 4982 5455 6175 5259 2821 3078 2535 2277 2958 2515 2615 2431 2362 2630 2396 2603 12.10_1106.99 4573 5695 6964 5156 3296 3984 5752 5315 4601 6230 4619 6307 24029 22427 21056 6332 7951 15571 20523 6626 6876 20902 16747 19296 12.10_1165.07 11056 12616 14167 9790 6857 8014 10507 9104 6610 10360 8627 10212 6605 6784 5837 4480 5483 5800 5582 4948 4517 6136 4741 5276 12.10_1065.95 21346 25266 25518 24584 15292 7410 9687 8731 18372 24900 8000 25374 111498 105900 100532 49721 76119 66194 89141 60600 65569 98057 74458 89541 12.10_1112.01 2404 2103 3518 3205 2842 2367 3396 2666 2003 3245 2567 3521 8555 8330 7879 5375 8472 6063 7639 6625 6027 9730 6257 7494 12.12_1152.04 2096 3243 3040 3187 2705 2024 3327 2428 4195 8899 7706 6820 5524 6486 6009 7319 5237 5603 7846 5966 6925 12.12_1117.97 8757 10345 11328 10158 5683 6553 11154 5145 6672 9103 7551 8889 51117 49121 44597 21626 31269 28314 44370 30661 32884 46425 35538 40164 12.12_879.82 235184 137552 47342 144323 459927 388512 246449 284198 453211 50673 266169 22651 4429 8698 18222 5127 19494 4387 4341 6035 11707 4716 23470 10560 12.12_1090.96 40255 44554 49500 42929 27162 32270 54238 46541 33552 16025 36913 46502 256736 239809 228754 109206 161750 139759 210620 146646 155232 222340 169600 198942 12.12_1245.96 3303 3351 4878 4056 2322 3836 3516 2655 4600 3354 5369 17928 17803 12901 8625 9896 13260 14474 8355 8723 15745 9239 14293 12.12_1079.96 4619 5919 5385 4457 6459 6199 4939 5561 4938 6048 5875 21997 5292 11081 16012 14004 18352 12538 14852 5970 15303 4751 12.12_848.77 38483 27886 13691 28649 89485 65552 50655 54808 76884 13765 41143 10872 5856 7035 7968 5851 7948 5353 4907 6252 6658 5315 9185 6736 12.12_1070.97 3813 5068 5703 4450 2959 3503 5529 4620 3664 5579 4170 5490 16657 9159 15815 4570 6349 5861 6750 9663 11182 8098 6169 6892 12.13_1038.92 5295 5499 5755 5357 3546 3843 6218 5607 4164 5470 4249 5222 17071 15438 14870 7732 11866 10717 14171 10622 12139 15045 12453 14460 12.13_1147.02 3054 4314 4830 4388 2308 2576 4459 2959 2500 4627 2703 5385 17529 16540 15075 9682 11855 11755 15660 11570 10600 15839 12169 14862 12.14_1077.96 8216 9898 9843 8814 5741 6475 12004 10315 6983 9400 7792 9518 39580 39114 36427 20833 29191 25947 31814 21849 24435 34843 28229 30289 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11594 10302 10230 12.06_1088.94_12.07_1071.92 9202 10500 12115 10386 6095 6883 12500 9969 6963 11558 8496 11603 45330 45175 39351 22209 30904 27486 38710 19676 28098 38166 29753 34711 12.11_1134.01_12.09_1116.97 8333 9686 11314 14969 9330 11787 11062 14768 11912 9589 8401 9986 78151 75426 71348 35479 48394 45588 69706 48188 49334 69985 50784 63970 12.16_1052.94_12.14_1069.97 14207 13944 26910 14218 15322 19767 19558 16790 12998 14765 14133 16049 112832 111319 103292 60251 84984 73348 87594 62607 69720 95261 77815 89441 12.21_1314.22_12.20_1331.25 83704 111992 140507 102595 42694 60089 97431 82051 46594 108216 77354 119247 355190 385673 325251 292213 366511 364498 355169 256440 259725 349783 278635 320447 12.24_1121.00_12.24_1138.04 19652 22417 25203 23950 12699 15531 31264 22899 17735 25546 19207 25029 111633 108114 101095 56786 81263 68791 95852 64020 69086 102833 78351 90490 4.94_836.54_4.94_858.53 62323 71710 82989 84365 72460 64486 69458 77403 63645 44876 56700 56848 150342 151273 123475 99407 149272 139184 149327 108326 118346 149201 119941 146721 5.00_926.58_5.00_948.57 31984 37733 41971 40687 37399 37839 39982 44100 36895 26717 34280 38908 28421 29829 24751 16091 25795 19824 32055 23125 23538 28466 21746 25298 5.03_1546.08_5.03_1568.07 16752 18937 23891 20981 18598 18555 24280 25215 19616 12335 16643 21317 11679 12236 8935 6050 12485 8841 17235 9008 9368 11838 7720 10307 5.03_1564.13_5.04_1586.11 15492 18961 21550 19943 16876 17302 21231 24548 17219 11821 16106 20497 9798 10090 7850 5327 10898 8382 14976 8461 8346 10588 6397 8473 5.04_998.58_5.03_976.60 204844 230533 248847 232418 215938 215685 235487 257140 220891 175809 212901 239469 171155 171844 144973 119108 184513 149169 208550 144956 152781 185037 136273 161371 5.09_885.55_5.08_863.56 14509 16785 17241 17395 16204 14854 15748 17423 14909 12684 14033 13355 11734 11046 9642 11004 12985 10834 10643 8832 10079 12754 11013 12133 5.09_1541.13_5.08_1563.12 14892 16802 19651 17210 16075 16195 18265 21820 16272 10826 14203 18474 15367 14600 11433 8624 15725 11611 22245 12894 12208 14995 10130 13059 5.12_952.60_5.13_974.58 356912 384519 410754 394893 376527 377796 396978 416878 381746 306321 360314 386591 399517 396357 357132 314007 413331 370195 436902 375423 367853 400410 333665 367534 5.27_807.57_5.26_785.59 266606 294417 333937 319717 294404 293213 337169 360550 302261 72290 87426 316530 260558 257216 229486 183827 267539 217196 312982 227402 226631 269777 55620 236198 5.62_1520.16_5.62_1542.14 15386 19212 23846 22228 18338 19038 21425 26951 17111 11525 14816 21459 12424 13505 9113 5907 13721 9106 23067 11378 11798 13619 8169 11311 5.63_954.61_5.62_976.60 193541 215080 252201 236217 215252 220135 236975 253513 211164 157679 205203 232206 173035 174719 144827 110643 187585 144048 243746 162682 166635 192176 130991 164199 5.64_1571.18_5.64_1593.16 6988 8602 10875 10983 9031 9722 10420 12477 9059 5257 7393 10166 5843 6640 4371 6092 4513 9407 4897 4666 6356 4976 5.66_1004.63_5.66_1026.61 52571 59908 69350 65581 58143 61165 64993 70977 59434 41659 55610 64620 43093 42632 34952 23283 43962 33202 56302 36968 36651 42433 29099 37001 5.80_980.63_5.79_1002.61 85204 95586 114381 113364 100926 99900 116083 130819 101670 66491 90902 106226 105099 105706 82939 52860 102461 73198 134670 76682 74928 105305 66395 86294 5.80_718.54_5.79_740.52 105420 115476 132741 128914 118213 119774 136527 139357 119521 92645 105742 112512 81466 79513 70739 54658 79460 65978 74454 54302 53245 64805 51649 59817 5.81_1555.15_5.81_1577.13 6790 8286 10171 9262 8374 8538 9897 11027 8385 2882 7159 8499 7586 7753 5054 2064 7879 5239 10792 5417 2741 7678 2622 5622 5.81_1576.13_5.81_1554.14 7310 8631 10905 9460 8691 9108 10807 11191 8558 3119 7356 8878 8189 7883 5589 2211 8468 5526 10614 3235 3380 7648 2476 5957 5.85_1536.10_5.85_1558.08 21250 23684 29873 26893 24836 25162 29455 29092 23669 15868 20458 23858 19464 19383 14952 10732 21332 16003 23878 13606 13113 17752 11023 15195 5.95_744.56_5.96_766.54 169919 186881 216472 204144 186788 192491 219813 230855 205134 166504 196330 201129 170241 170398 147029 123494 185850 157540 187915 136484 132796 172347 130605 150161 7.05_662.57_7.05_667.53 8014 9910 9509 8692 7838 9217 8976 10200 7979 9559 9377 10217 7763 7686 7519 11110 17010 14859 16075 11399 11438 11823 9597 9301 9.14_1449.98_9.14_1471.96 19453 24197 32184 24809 22359 19705 22403 23811 19465 17231 21715 20307 25466 26817 22792 24717 41428 31358 32769 18189 20499 30368 23495 27013 9.56_880.72_9.56_863.69 54643 58666 64939 61309 57817 56197 56766 52002 56150 43909 52583 52708 67200 70065 59032 49592 74060 63001 64241 49054 47699 64087 53228 59558 9.67_969.71_9.67_991.69 38300 39369 41303 39980 37883 39057 41806 39643 40293 29866 33744 35452 9658 9701 8372 2841 3656 3141 4213 3647 3751 7670 4156 7144 9.73_995.73_9.72_1017.71 35632 38160 37684 37345 37535 36291 40753 35807 36964 29931 32285 32813 15377 15057 13957 4941 6234 5551 9651 8562 6467 11587 9578 10854 9.80_1021.74_9.79_1043.73 29874 31669 32427 33193 31121 31988 34825 31277 31622 24820 26951 27473 18071 18361 16526 6031 10561 9764 14502 10839 12024 15700 13284 14413 9.87_1047.76_9.86_1069.74 29375 31995 33276 33745 30818 30592 32955 31801 30199 26824 27775 26624 24815 24218 22281 9491 14682 13144 20525 16347 17991 21834 18095 21015 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Quanitied m/z Retention Time KEGG ID PubChem ID 8.12_636.63_8.12_658.61 636.6291_658.6103 8.120_8.122 7.80_604.60_7.80_622.61_7.81_644.59 604.6023_622.6133_644.5949 7.800_7.802_7.808 8.44_672.63_8.44_632.63_8.44_650.64 672.6257_632.6336_650.6446 8.438_8.440_8.441 7.76_648.63_7.77_630.62_7.77_670.61 648.6272_630.6179_670.6104 7.763_7.767_7.773 4.93_369.35 369.352 4.932 7.04_617.51_7.05_612.56 617.5119_612.5560 7.044_7.048 7.12_643.53_7.12_638.57 643.5290_638.5747 7.116_7.119 6.56_641.51_6.57_636.56 641.5122_636.5565 6.563_6.567 4.89_862.62 862.6249 4.887 1.59_496.34 496.34 1.593 2.36_524.37 524.3711 2.361 5.61_760.58_5.63_782.57 760.5825_782.5681 5.613_5.626 10.98_859.78_10.99_876.80_10.99_881.76 859.7768_876.8014_881.7619 10.977_10.989_10.992 4.91_706.54 706.5407 4.908 4.40_704.52 704.5225 4.398 5.21_720.55 720.5541 5.213 5.54_734.57_5.55_756.55 734.5706_756.5513 5.542_5.546 4.99_732.55_4.99_754.54 732.5543_754.5359 4.986_4.995 4.52_730.54 730.5382 4.518 4.90_728.52 728.5213 4.907 5.75_748.58 748.5843 5.75 5.30_746.57 746.569 5.295 4.82_744.55 744.5543 4.817 5.12_758.57_5.13_780.55 758.5698_780.5516 5.125_5.127 4.70_756.55 756.5536 4.701 4.44_754.54 754.5379 4.437 5.43_772.59 772.5856 5.426 4.92_770.57 770.5682 4.923 4.73_768.55 768.5538 4.728 6.28_788.62 788.6165 6.278 5.77_786.60 786.6009 5.774 5.29_784.58 784.5827 5.286 5.03_782.57_5.03_804.55 782.5686_804.5515 5.028_5.031 4.31_778.54 778.5387 4.306 5.35_796.59 796.5857 5.35 6.35_814.63 814.633 6.349 5.95_812.62 812.616 5.949 5.67_810.60_5.66_832.58 810.5990_832.5833 5.671_5.665 6.28_810.62 810.5988 6.279 5.07_808.58_5.07_830.57 808.5837_830.5669 5.072_5.068 4.89_806.57_4.89_828.55 806.5681_828.5517 4.888_4.888 4.39_804.55 804.5538 4.387 6.14_838.63 838.6315 6.136 5.69_836.61_5.68_858.60 836.6135_858.5979 5.691_5.680 5.50_834.60_5.50_856.58 834.5989_856.5831 5.496_5.497 4.93_832.58 832.5841 4.933 4.50_830.57 830.5687 4.504 5.94_720.59 720.5895 5.937 6.05_796.61 796.6136 6.05 5.45_794.60 794.603 5.447 5.22_818.60 818.6032 5.221 5.29_716.52_5.29_738.50 716.5231_738.5045 5.294_5.290 6.47_746.57 746.5699 6.471 5.83_768.56 768.555 5.826 5.03_764.52 764.5231 5.027 5.49_724.53 724.5274 5.489 6.16_752.56 752.5586 6.162 5.54_750.54 750.5431 5.539 4.22_675.54 675.5435 4.224 4.52_689.56 689.5584 4.515 5.05_705.59 705.59 5.053 4.83_703.57_4.84_725.56 703.5748_725.5554 4.832_4.838 4.32_701.56 701.5589 4.32 5.74_733.62 733.6166 5.737 5.49_731.61_5.50_753.59 731.6052_753.5872 5.494_5.497 4.94_729.59 729.5896 4.936 6.18_759.64 759.6363 6.184 6.53_773.65 773.6515 6.533 7.09_789.68 789.681 7.091 6.87_787.67_6.86_809.65 787.6683_809.6503 6.867_6.862 6.28_785.65 785.6522 6.283 7.20_801.68 801.6841 7.203 6.53_799.67 799.668 6.526 7.53_815.70 815.6998 7.529 6.84_813.68_6.84_835.67 813.6841_835.6660 6.837_6.838 6.27_811.67 811.6658 6.275 7.77_829.72 829.7154 7.77 9.60_740.68 740.6764 9.602 9.62_771.65_9.63_766.69 771.6477_766.6922 9.623_9.629 10.55_796.74 796.7391 10.546 9.67_792.71_9.67_797.66 792.7081_797.6641 9.669_9.670 9.23_790.69_9.24_795.65 790.6917_795.6487 9.229_9.237 10.52_827.71_10.55_822.75 827.7112_822.7549 10.522_10.548 10.14_825.70_10.15_820.74 825.7000_820.7379 10.139_10.150 9.73_823.68_9.73_818.72 823.6806_818.7237 9.726_9.731 10.12_794.72_10.09_799.68 794.7231_799.679 10.119_10.093 10.74_836.77_10.78_841.73 836.7707_841.7271 10.741_10.776 10.36_834.75 834.7545 10.358 9.96_832.74 832.7392 9.958 10.98_850.79 850.7855 10.975 10.58_848.77 848.7704 10.578 10.18_851.71_10.20_846.75 851.7149_846.7540 10.182_10.200 9.80_849.70_9.80_844.74 849.6968_844.7387 9.796_9.798 9.39_847.68_9.40_842.72 847.6821_842.7222 9.392_9.399 11.13_864.80 864.8026 11.129 10.78_862.79 862.7866 10.783 10.41_860.77 860.7702 10.411 10.04_858.75 858.7546 10.04 11.36_883.78_11.37_878.82 883.7828_878.8173 11.364_11.368 11.37_910.80_11.37_905.84 910.7971_905.8374 11.375_11.37 10.64_874.79 874.7863 10.637 10.26_872.77_10.26_877.73 872.7688_877.7305 10.261_10.263 9.87_875.71_9.87_870.75 875.7143_870.7537 9.868_9.870 9.46_868.74_9.49_873.70 868.7383_873.7022 9.462_9.494 11.55_892.84_11.53_897.80 892.8354_897.7981 11.547_11.535 11.15_890.82 890.8192 11.146 10.80_888.80 888.8021 10.801 10.45_886.79 886.7859 10.452 10.08_884.77 884.7698 10.079 11.71_911.81 911.8084 11.713 11.44_906.85_11.37_911.80 906.8469_911.7967 11.44_11.371 11.77_906.85 906.8501 11.771 11.37_904.83 904.8331 11.373 11.02_902.82 902.8164 11.021 10.66_900.80 900.7997 10.664 10.29_898.78 898.7839 10.291 9.92_896.77_9.93_901.73 896.7692_901.7320 9.925_9.929 11.92_934.88 934.8809 11.925 11.76_932.87 932.8661 11.764 11.37_930.85 930.85 11.367 11.05_928.83 928.8316 11.053 10.91_926.81 926.8142 10.906 10.52_924.80 924.7983 10.517 10.19_922.78 922.7836 10.194 9.96_920.77 920.7718 9.961 12.03_962.91 962.9101 12.029 11.91_960.89 960.893 11.911 11.73_958.88 958.8818 11.729 10.89_952.83 952.8315 10.887 10.35_948.80_10.34_965.83 948.8006_965.8327 10.350_10.337 10.55_549.49 549.4881 10.553 6.50_610.54_6.50_615.49 610.5422_615.4949 6.505_6.501 9.11_738.66_9.10_743.62 738.6605_743.6163 9.110_9.100 9.67_813.64 813.6379 9.668 9.16_764.68_9.16_769.63 764.6761_769.6317 9.162_9.164 11.03_929.83 929.8279 11.031 9.56_885.67 885.6749 9.557 10.64_915.82 915.8155 10.644 9.79_865.67 865.6699 9.791 10.64_895.72 895.7174 10.643 9.30_816.71_9.31_821.67 816.7063_821.6650 9.303_9.306 11.36_899.76 899.759 11.357 10.12_841.67 841.6681 10.124 10.18_867.69 867.6852 10.177 11.07_551.50 551.5048 11.066 10.64_601.52 601.5194 10.643 10.98_897.74 897.7398 10.975 10.68_897.73 897.726 10.679 10.54_369.35 369.352 10.538 11.37_925.77 925.7679 11.37 10.26_893.70 893.7009 10.259 11.36_931.85 931.8536 11.365 10.32_808.74 808.7388 10.32 5.13_848.54 848.5388 5.128 5.12_1516.13_5.13_1538.11 1516.1316_1538.1132 5.125_5.126 4.96_627.53 627.5348 4.962 4.96_904.59_4.96_887.56 904.5914_887.564 4.963_4.963 10.98_577.52 577.5202 10.977 5.77_876.57 876.5707 5.769 5.13_1159.84 1159.835 5.127 4.93_577.52 577.5192 4.928 5.78_866.54 866.5413 5.784 5.09_603.53 603.5346 5.086 11.00_603.54 603.5363 10.996 5.62_850.56 850.5562 5.619 5.04_872.54 872.5389 5.037 0.52_162.11 162.1129 0.518 0.52_104.11 104.1072 0.521 0.54_123.06 123.056 0.54 0.57_247.18 247.1806 0.569 0.57_311.16 311.1562 0.57 0.57_325.17 325.1716 0.572 0.61_262.16 262.1593 0.611 0.68_228.20 228.1956 0.682 0.83_249.21 249.2059 0.83 1.59_923.01 923.0129 1.585 1.62_454.29 454.2934 1.622 2.42_482.32 482.3249 2.418 4.36_337.27 337.274 4.363 4.39_808.51 808.5119 4.393 4.41_808.56 808.5568 4.406 4.43_599.50 599.503 4.43 4.50_575.50 575.5015 4.502 4.63_974.58 974.5809 4.635 4.64_802.54 802.536 4.636 4.65_807.57 807.5729 4.646 4.73_769.56 769.5566 4.731 4.74_784.58 784.5751 4.736 4.76_339.29 339.2898 4.76 4.78_738.51 738.5069 4.781 4.84_726.56 726.5577 4.837 4.88_619.00 619.0024 4.878 4.88_651.53 651.5345 4.885 4.89_1000.60 1000.5972 4.886 4.89_714.51 714.5074 4.887 4.91_741.53 741.5255 4.908 4.93_854.57 854.5719 4.927 4.93_794.57 794.5695 4.929 4.93_859.53 859.5326 4.93 4.97_909.55 909.5464 4.969 4.98_809.58 809.583 4.981 5.00_755.54 755.5387 4.996 5.01_1651.08 1651.0783 5.009 5.02_841.62 841.6249 5.021 5.02_958.55 958.5512 5.023 5.02_840.62 840.6214 5.024 5.02_787.51 787.5101 5.025 5.03_623.50 623.5025 5.026 5.03_653.55 653.55 5.027 5.03_1528.04 1528.0372 5.028 5.03_1548.09 1548.0918 5.028 5.03_784.82 784.8241 5.03 5.03_862.51 862.5106 5.034 5.04_1588.12 1588.1188 5.045 5.07_1566.13 1566.1347 5.067 5.07_978.61 978.6083 5.069 5.07_1002.61 1002.6129 5.072 5.08_1562.11 1562.1103 5.08 5.08_864.56 864.5587 5.082 5.08_1522.08 1522.0822 5.082 5.08_880.59 880.5899 5.084 5.10_786.53 786.5322 5.095 5.10_1567.14 1567.1379 5.101 5.10_790.54 790.5411 5.101 5.10_811.59 811.5927 5.102 5.10_838.53 838.5263 5.104 5.11_812.54 812.5437 5.113 5.12_1540.12 1540.1222 5.119 5.12_184.07 184.0742 5.121 5.12_777.54 777.5437 5.125 5.12_761.58 761.5784 5.125 5.13_398.76 398.762 5.125 5.13_1159.33 1159.3335 5.125 5.13_758.81 758.8133 5.126 5.13_816.62 816.6214 5.126 5.13_1539.12 1539.1166 5.127 5.13_840.51 840.5147 5.127 5.13_839.53 839.5271 5.129 5.15_690.51 690.5073 5.15 5.16_1498.09 1498.0854 5.156 5.19_599.50 599.5033 5.188 5.19_796.54 796.5365 5.189 5.19_934.55 934.5516 5.189 5.19_740.52 740.5224 5.191 5.19_763.51 763.5149 5.192 5.23_789.54 789.538 5.228 5.23_788.54 788.5409 5.229 5.24_979.62 979.6167 5.236 5.24_812.58 812.5835 5.243 5.24_766.54 766.5417 5.245 5.25_629.55 629.55 5.247 5.25_889.58 889.5802 5.249 5.25_810.59 810.5926 5.252 5.27_911.56 911.556 5.267 5.29_787.59 787.594 5.286 5.29_575.50 575.5031 5.29 5.29_743.54 743.5379 5.293 5.30_749.54 749.5382 5.299 5.30_748.55 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11.11_955.85 955.849 11.109 11.12_982.85 982.8535 11.115 11.13_923.01 923.0124 11.127 11.13_865.81 865.8055 11.127 11.13_1041.81 1041.8053 11.135 11.14_591.54 591.5354 11.137 11.15_1063.79 1063.7874 11.155 11.17_972.90 972.896 11.167 11.17_1067.82 1067.8208 11.17 11.18_916.84 916.8353 11.18 11.22_552.51 552.5091 11.22 11.23_838.79 838.7869 11.23 11.26_947.88 947.8827 11.259 11.26_896.79 896.7909 11.262 11.28_854.80 854.7995 11.278 11.28_948.89 948.8875 11.279 11.28_827.77 827.771 11.283 11.31_911.78 911.7768 11.313 11.34_945.87 945.8654 11.342 11.35_866.82 866.8168 11.346 11.35_900.79 900.7863 11.354 11.36_934.87 934.8735 11.356 11.36_578.52 578.5229 11.357 11.36_1058.83 1058.8285 11.362 11.36_605.55 605.5522 11.364 11.37_960.90 960.8951 11.366 11.37_920.86 920.8648 11.367 11.37_1012.93 1012.9334 11.367 11.37_1081.84 1081.8388 11.369 11.37_946.88 946.8814 11.369 11.37_988.92 988.9186 11.37 11.37_1013.93 1013.9302 11.37 11.37_607.56 607.5579 11.371 11.37_1082.84 1082.8403 11.371 11.37_986.91 986.9136 11.372 11.38_1103.82 1103.8249 11.379 11.38_909.80 909.8 11.382 11.40_957.87 957.869 11.395 11.40_826.78 826.7791 11.403 11.42_910.82 910.8245 11.418 11.48_580.54 580.5381 11.48 11.48_824.77 824.7722 11.481 11.50_839.79 839.7911 11.497 11.50_881.82 881.8233 11.501 11.51_579.54 579.5375 11.506 11.51_898.80 898.797 11.506 11.52_918.85 918.853 11.52 11.53_944.87 944.8709 11.531 11.59_935.88 935.8807 11.585 11.70_974.91 974.9118 11.699 11.70_938.83 938.8339 11.699 11.70_1109.87 1109.8707 11.702 11.70_1014.94 1014.9444 11.703 11.70_1000.93 1000.9286 11.704 11.72_988.93 988.9288 11.719 11.72_853.81 853.8072 11.725 11.73_948.90 948.8962 11.73 11.73_984.90 984.8985 11.735 11.76_908.86 908.8596 11.765 11.83_947.89 947.8858 11.826 11.90_1002.94 1002.9403 11.903 11.91_1042.98 1042.9766 11.905 11.92_920.87 920.8671 11.919 11.92_1157.05 1157.0474 11.921 11.96_880.83 880.8323 11.957 11.96_1131.03 1131.0288 11.963 11.98_1047.91 1047.9108 11.978 11.98_1089.94 1089.9434 11.985 11.99_1137.92 1137.9156 11.989 12.00_1241.94 1241.94 11.997 12.00_906.85 906.8496 12.002 12.02_989.93 989.9322 12.016 12.02_1105.99 1105.9887 12.019 12.02_1030.97 1030.9722 12.022 12.03_1105.00 1105.001 12.026 12.03_1016.96 1016.9616 12.026 12.03_1044.99 1044.9913 12.027 12.03_1004.96 1004.9606 12.031 12.05_1076.95 1076.9518 12.046 12.05_1062.92 1062.923 12.051 12.06_1114.95 1114.9515 12.055 12.06_864.81 864.8054 12.057 12.06_899.79 899.7865 12.058 12.06_873.77 873.7676 12.06 12.06_871.76 871.756 12.061 12.06_1159.02 1159.023 12.062 12.06_1049.93 1049.9293 12.063 12.06_1166.08 1166.0798 12.063 12.06_1243.96 1243.9584 12.063 12.06_177.16 177.1638 12.064 12.07_1160.05 1160.0548 12.067 12.07_1195.12 1195.1242 12.07 12.07_1097.95 1097.9539 12.075 12.08_1072.92 1072.916 12.081 12.08_1133.01 1133.0078 12.082 12.08_1075.94 1075.9388 12.082 12.08_1199.05 1199.0472 12.083 12.08_1173.03 1173.0312 12.085 12.09_1050.93 1050.9335 12.089 12.09_1063.93 1063.9322 12.089 12.09_1104.98 1104.9796 12.092 12.09_1269.97 1269.9719 12.093 12.09_1244.96 1244.9612 12.094 12.10_1017.96 1017.9626 12.096 12.10_1106.99 1106.9866 12.1 12.10_1165.07 1165.0748 12.1 12.10_1065.95 1065.9451 12.101 12.10_1112.01 1112.0068 12.102 12.12_1152.04 1152.0403 12.117 12.12_1117.97 1117.9744 12.119 12.12_879.82 879.8214 12.119 12.12_1090.96 1090.9554 12.12 12.12_1245.96 1245.9632 12.12 12.12_1079.96 1079.9581 12.121 12.12_848.77 848.7717 12.123 12.12_1070.97 1070.9736 12.125 12.13_1038.92 1038.9236 12.126 12.13_1147.02 1147.0151 12.128 12.14_1077.96 1077.9625 12.139 12.14_1297.99 1297.994 12.139 12.14_878.82 878.818 12.143 12.14_1097.99 1097.993 12.144 12.14_1271.98 1271.9832 12.144 12.15_1233.14 1233.1422 12.146 12.15_1263.19 1263.1914 12.147 12.15_793.69 793.6893 12.15 12.15_819.70 819.7028 12.151 12.15_794.72 794.7152 12.152 12.16_892.83 892.8346 12.156 12.16_1111.01 1111.0078 12.156 12.16_1150.04 1150.039 12.162 12.16_1136.02 1136.0217 12.162 12.16_850.79 850.7875 12.164 12.16_1092.97 1092.9692 12.164 12.17_1151.04 1151.041 12.168 12.18_1201.06 1201.0609 12.179 12.18_1149.03 1149.0338 12.183 12.18_1175.05 1175.0481 12.183 12.18_822.75 822.7547 12.183 12.18_1135.02 1135.0176 12.183 12.18_852.80 852.8023 12.184 12.18_1118.98 1118.9848 12.184 12.19_1146.00 1145.996 12.186 12.19_1109.00 1109.0015 12.187 12.19_1345.23 1345.2298 12.189 12.19_1066.96 1066.9555 12.19 12.19_821.73 821.7279 12.192 12.20_1082.98 1082.9778 12.196 12.21_1301.20 1301.2035 12.208 12.21_1095.96 1095.9597 12.21 12.21_1080.97 1080.971 12.212 12.21_796.74 796.7404 12.215 12.22_824.77 824.7718 12.218 12.22_1124.02 1124.0168 12.219 12.22_1163.04 1163.0438 12.22 12.22_1203.07 1203.0747 12.222 12.23_1095.99 1095.9901 12.235 12.24_838.79 838.7873 12.24 12.24_1413.29 1413.2937 12.242 12.25_1402.34 1402.3367 12.252 12.25_1382.28 1382.2817 12.255 12.27_810.76 810.7569 12.274 12.28_866.82 866.819 12.281 12.29_1468.38 1468.3824 12.293 12.33_1536.44 1536.442 12.333 12.37_1604.50 1604.5022 12.368 12.51_1596.50 1596.5042 12.507 12.55_1626.55 1626.5462 12.549 12.94_923.01 923.0108 12.944 0.52_137.05_0.52_159.03 137.0484_159.0278 0.522_0.517 10.10_971.73_10.08_993.71 971.7257_993.7081 10.099_10.080 10.42_1037.77_10.42_1059.75 1037.7726_1059.7530 10.418_10.424 10.65_858.76_10.64_875.79 858.7629_875.7897 10.650_10.637 10.79_1039.79_10.79_1061.77 1039.7887_1061.7704 10.791_10.790 11.36_1055.82_11.35_1077.81 1055.8228_1077.8088 11.365_11.351 11.72_1083.85_11.71_1105.84 1083.8544_1105.8353 11.718_11.711 11.91_986.91_11.91_1003.95 986.9146_1003.9484 11.908_11.910 12.06_1088.94_12.07_1071.92 1088.939_1071.9178 12.057_12.066 12.11_1134.01_12.09_1116.97 1134.0082_1116.9723 12.105_12.086 12.16_1052.94_12.14_1069.97 1052.9381_1069.9665 12.159_12.142 12.21_1314.22_12.20_1331.25 1314.2216_1331.2548 12.205_12.204 12.24_1121.00_12.24_1138.04 1121.0042_1138.0367 12.236_12.240 4.94_836.54_4.94_858.53 836.5449_858.5301 4.940_4.937 5.00_926.58_5.00_948.57 926.5818_948.5670 4.997_4.995 5.03_1546.08_5.03_1568.07 1546.0835_1568.0713 5.029_5.030 5.03_1564.13_5.04_1586.11 1564.1268_1586.1114 5.033_5.036 5.04_998.58_5.03_976.60 998.5796_976.597 5.038_5.029 5.09_885.55_5.08_863.56 885.5461_863.5603 5.085_5.082 5.09_1541.13_5.08_1563.12 1541.1277_1563.1162 5.091_5.079 5.12_952.60_5.13_974.58 952.5984_974.5799 5.125_5.127 5.27_807.57_5.26_785.59 807.5702_785.5859 5.269_5.256 5.62_1520.16_5.62_1542.14 1520.1622_1542.1435 5.623_5.624 5.63_954.61_5.62_976.60 954.6137_976.5952 5.627_5.625 5.64_1571.18_5.64_1593.16 1571.1778_1593.1621 5.640_5.642 5.66_1004.63_5.66_1026.61 1004.6279_1026.6115 5.663_5.664 5.80_980.63_5.79_1002.61 980.6293_1002.6109 5.796_5.792 5.80_718.54_5.79_740.52 718.5442_740.5231 5.801_5.790 5.81_1555.15_5.81_1577.13 1555.1497_1577.1317 5.809_5.813 5.81_1576.13_5.81_1554.14 1576.126_1554.1444 5.813_5.807 5.85_1536.10_5.85_1558.08 1536.0996_1558.0840 5.848_5.848 5.95_744.56_5.96_766.54 744.5563_766.5368 5.948_5.956 7.05_662.57_7.05_667.53 662.5711_667.5265 7.051_7.055 9.14_1449.98_9.14_1471.96 1449.9792_1471.9610 9.144_9.144 9.56_880.72_9.56_863.69 880.7186_863.6908 9.559_9.559 9.67_969.71_9.67_991.69 969.7115_991.6922 9.672_9.670 9.73_995.73_9.72_1017.71 995.7263_1017.7081 9.730_9.723 9.80_1021.74_9.79_1043.73 1021.7416_1043.7257 9.795_9.791 9.87_1047.76_9.86_1069.74 1047.7573_1069.7400 9.870_9.864 METABOLITES_END #END