#METABOLOMICS WORKBENCH agil@ua.pt_20170220_070740 DATATRACK_ID:850 STUDY_ID:ST000590 ANALYSIS_ID:AN000905 PROJECT_ID:PR000431 VERSION 1 CREATED_ON April 13, 2017, 3:37 pm #PROJECT PR:PROJECT_TITLE Age-related Macular Degeneration: A Novel Integrative Approach to Identify PR:PROJECT_TITLE Biomarkers PR:PROJECT_TYPE Cross-sectional, observational, multi-site, metabolomics by NMR PR:PROJECT_SUMMARY This is a collaborative project between several Portuguese Institutions and PR:PROJECT_SUMMARY Massachusetts Eye and Ear, Harvard Medical School, Boston, US. The main goal is PR:PROJECT_SUMMARY to identify integrative biomarkers of Age-related Macular Degeneration (AMD). We PR:PROJECT_SUMMARY prospectively recruited subjects in both countries. For all participants, a PR:PROJECT_SUMMARY complete medical history was obtained, and they were all submitted to a complete PR:PROJECT_SUMMARY ophthalmologic exam, as well as imaging. All subjects provided fasting blood and PR:PROJECT_SUMMARY urine samples. PR:INSTITUTE University of Aveiro PR:DEPARTMENT Department of Chemistry and CICECO_Aveiro Institute of Materials PR:LABORATORY University of Aveiro PR:LAST_NAME Gil PR:FIRST_NAME Ana PR:ADDRESS Campus de Santiago, Aveiro, Aveiro, 3810-193, Portugal PR:EMAIL agil@ua.pt PR:PHONE +351234370707 #STUDY ST:STUDY_TITLE Human Plasma Metabolomics in Age-related Macular Degeneration (AMD) Using ST:STUDY_TITLE Nuclear Magnetic Resonance Spectroscopy ST:STUDY_TYPE Observational, cross-sectional, multi-site study, NMR metabolomics ST:STUDY_SUMMARY Multi-site, cross-sectional study, including subjects with Age-related Macular ST:STUDY_SUMMARY Degeneration (early, intermediate and late disease) and a control group of ST:STUDY_SUMMARY subjects without any macular diseases. Plasma metabolomic profiles were assessed ST:STUDY_SUMMARY using Nuclear Magnetic Resonance Spectroscopy (NMR). Multivariate statistics ST:STUDY_SUMMARY were performed to compare metabolomic profiles of AMD patients vs controls. ST:INSTITUTE University of Aveiro ST:DEPARTMENT Department of Chemistry and CICECO_Aveiro Institute of Materials ST:LABORATORY University of Aveiro ST:LAST_NAME Gil ST:FIRST_NAME Ana ST:ADDRESS Campus de Santiago, Aveiro, Aveiro, 3810-193, Portugal ST:EMAIL agil@ua.pt ST:PHONE +351234370707 ST:NUM_GROUPS 4 ST:TOTAL_SUBJECTS 396 ST:NUM_MALES 143 ST:NUM_FEMALES 253 #SUBJECT SU:SUBJECT_TYPE HUman SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:AGE_OR_AGE_RANGE 51-95 SU:GENDER 253 female; 143 male SU:HUMAN_SMOKING_STATUS 5 smokers; 113 ex-smokers; 275 non smokers SU:HUMAN_INCLUSION_CRITERIA For AMD group: clinical diagnosis of AMD, confirmed on color fundus photographs; SU:HUMAN_INCLUSION_CRITERIA For controls: age equal or superior than 50 years old, with normal macular SU:HUMAN_INCLUSION_CRITERIA health SU:HUMAN_EXCLUSION_CRITERIA Diagnosis of any other vitreoretinal disease, active uveitis or ocular SU:HUMAN_EXCLUSION_CRITERIA infection, significant media opacities that precluded the observation of the SU:HUMAN_EXCLUSION_CRITERIA ocular fundus, refractive error equal or greater than 6 diopters of spherical SU:HUMAN_EXCLUSION_CRITERIA equivalent, past history of retinal surgery, history of any ocular surgery or SU:HUMAN_EXCLUSION_CRITERIA intra-ocular procedure (such as laser and intra-ocular injections) within the 90 SU:HUMAN_EXCLUSION_CRITERIA days prior to enrolment, and diagnosis of diabetes mellitus, with or without SU:HUMAN_EXCLUSION_CRITERIA concomitant diabetic retinopathy. #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS AMD01_001 AMD01_001 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=28,71701156 SUBJECT_SAMPLE_FACTORS AMD01_002 AMD01_002 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=66; Body mass index=31,06518555 SUBJECT_SAMPLE_FACTORS AMD01_003 AMD01_003 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=66; Body mass index=23,62745562 SUBJECT_SAMPLE_FACTORS AMD01_004 AMD01_004 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=68; Body mass index=31,37355372 SUBJECT_SAMPLE_FACTORS AMD01_005 AMD01_005 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=32,49556571 SUBJECT_SAMPLE_FACTORS AMD01_006 AMD01_006 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=69; Body mass index=27,4609375 SUBJECT_SAMPLE_FACTORS AMD01_007 AMD01_007 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=79; Body mass index=53,45123967 SUBJECT_SAMPLE_FACTORS AMD01_009 AMD01_009 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=61; Body mass index=34,05536332 SUBJECT_SAMPLE_FACTORS AMD01_010 AMD01_010 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=42,91289438 SUBJECT_SAMPLE_FACTORS AMD01_011 AMD01_011 AMD stage:Intermediate | Gender:Male | Smoking:Smoker | Cohort:Boston Age=73; Body mass index=27,36591696 SUBJECT_SAMPLE_FACTORS AMD01_012 AMD01_012 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=73; Body mass index=27,96130073 SUBJECT_SAMPLE_FACTORS AMD01_013 AMD01_013 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=69; Body mass index=24,53706 SUBJECT_SAMPLE_FACTORS AMD01_014 AMD01_014 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=24,95857988 SUBJECT_SAMPLE_FACTORS AMD01_015 AMD01_015 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=78; Body mass index=34,00755858 SUBJECT_SAMPLE_FACTORS AMD01_017 AMD01_017 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=77; Body mass index=37,27199822 SUBJECT_SAMPLE_FACTORS AMD01_018 AMD01_018 AMD stage:Intermediate | Gender:Male | Smoking:Smoker | Cohort:Boston Age=68; Body mass index=30,66345271 SUBJECT_SAMPLE_FACTORS AMD01_019 AMD01_019 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=85; Body mass index=23,80396525 SUBJECT_SAMPLE_FACTORS AMD01_020 AMD01_020 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=79; Body mass index=26,08789063 SUBJECT_SAMPLE_FACTORS AMD01_021 AMD01_021 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=77; Body mass index=20,25244141 SUBJECT_SAMPLE_FACTORS AMD01_022 AMD01_022 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=26,46625084 SUBJECT_SAMPLE_FACTORS AMD01_023 AMD01_023 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=71; Body mass index=33,89118457 SUBJECT_SAMPLE_FACTORS AMD01_025 AMD01_025 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=69; Body mass index=25,79944455 SUBJECT_SAMPLE_FACTORS AMD01_027 AMD01_027 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=63; Body mass index=31,75170898 SUBJECT_SAMPLE_FACTORS AMD01_028 AMD01_028 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=27,36591696 SUBJECT_SAMPLE_FACTORS AMD01_029 AMD01_029 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=73; Body mass index=27,24927601 SUBJECT_SAMPLE_FACTORS AMD01_031 AMD01_031 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=80; Body mass index=24,54433644 SUBJECT_SAMPLE_FACTORS AMD01_032 AMD01_032 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=88; Body mass index=24,02832031 SUBJECT_SAMPLE_FACTORS AMD01_034 AMD01_034 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=61; Body mass index=35,15 SUBJECT_SAMPLE_FACTORS AMD01_035 AMD01_035 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=64; Body mass index=27,11294766 SUBJECT_SAMPLE_FACTORS AMD01_036 AMD01_036 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=76; Body mass index=23,08594483 SUBJECT_SAMPLE_FACTORS AMD01_041 AMD01_041 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=85; Body mass index=26,43115234 SUBJECT_SAMPLE_FACTORS AMD01_042 AMD01_042 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=91; Body mass index=18,32598764 SUBJECT_SAMPLE_FACTORS AMD01_043 AMD01_043 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=71; Body mass index=28,3190918 SUBJECT_SAMPLE_FACTORS AMD01_044 AMD01_044 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=77; Body mass index=28,86748661 SUBJECT_SAMPLE_FACTORS AMD01_048 AMD01_048 AMD stage:Early | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=74; Body mass index=26,62878788 SUBJECT_SAMPLE_FACTORS AMD01_049 AMD01_049 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=64; Body mass index=27,36591696 SUBJECT_SAMPLE_FACTORS AMD01_051 AMD01_051 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=70; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD01_053 AMD01_053 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=56; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD01_054 AMD01_054 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=87; Body mass index=23,04318418 SUBJECT_SAMPLE_FACTORS AMD01_055 AMD01_055 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=67; Body mass index=26,38393695 SUBJECT_SAMPLE_FACTORS AMD01_056 AMD01_056 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=67; Body mass index=20,63242604 SUBJECT_SAMPLE_FACTORS AMD01_057 AMD01_057 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=70; Body mass index=30,03540039 SUBJECT_SAMPLE_FACTORS AMD01_058 AMD01_058 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=70; Body mass index=23,37084 SUBJECT_SAMPLE_FACTORS AMD01_059 AMD01_059 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=77; Body mass index=23,98651 SUBJECT_SAMPLE_FACTORS AMD01_060 AMD01_060 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=72; Body mass index=23,29467456 SUBJECT_SAMPLE_FACTORS AMD01_061 AMD01_061 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=75; Body mass index=20,34801289 SUBJECT_SAMPLE_FACTORS AMD01_062 AMD01_062 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=69; Body mass index=23,77471384 SUBJECT_SAMPLE_FACTORS AMD01_063 AMD01_063 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=85; Body mass index=21,03147763 SUBJECT_SAMPLE_FACTORS AMD01_064 AMD01_064 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=73; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD01_065 AMD01_065 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=79; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD01_068 AMD01_068 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=62; Body mass index=31,10083309 SUBJECT_SAMPLE_FACTORS AMD01_070 AMD01_070 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=62; Body mass index=30,03540039 SUBJECT_SAMPLE_FACTORS AMD01_072 AMD01_072 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=34,16683198 SUBJECT_SAMPLE_FACTORS AMD01_073 AMD01_073 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=74; Body mass index=24,08868733 SUBJECT_SAMPLE_FACTORS AMD01_075 AMD01_075 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=75; Body mass index=25,32854623 SUBJECT_SAMPLE_FACTORS AMD01_076 AMD01_076 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=71; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD01_077 AMD01_077 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=72; Body mass index=31,92690311 SUBJECT_SAMPLE_FACTORS AMD01_078 AMD01_078 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=85; Body mass index=24,21444444 SUBJECT_SAMPLE_FACTORS AMD01_079 AMD01_079 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=76; Body mass index=28,35034657 SUBJECT_SAMPLE_FACTORS AMD01_080 AMD01_080 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=68; Body mass index=26,25952148 SUBJECT_SAMPLE_FACTORS AMD01_083 AMD01_083 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=67; Body mass index=29,75661376 SUBJECT_SAMPLE_FACTORS AMD01_084 AMD01_084 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=24,68912591 SUBJECT_SAMPLE_FACTORS AMD01_085 AMD01_085 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=25,39828681 SUBJECT_SAMPLE_FACTORS AMD01_086 AMD01_086 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=23,67244898 SUBJECT_SAMPLE_FACTORS AMD01_095 AMD01_095 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=72; Body mass index=24,68696845 SUBJECT_SAMPLE_FACTORS AMD02_001 AMD02_001 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=28,50211628 SUBJECT_SAMPLE_FACTORS AMD02_002 AMD02_002 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=68; Body mass index=22,31165453 SUBJECT_SAMPLE_FACTORS AMD02_004 AMD02_004 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=84; Body mass index=25,8244898 SUBJECT_SAMPLE_FACTORS AMD02_005 AMD02_005 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=69; Body mass index=31,86824846 SUBJECT_SAMPLE_FACTORS AMD02_006 AMD02_006 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=70; Body mass index=30,78224852 SUBJECT_SAMPLE_FACTORS AMD02_007 AMD02_007 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=78; Body mass index=34,2764497 SUBJECT_SAMPLE_FACTORS AMD02_009 AMD02_009 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=75; Body mass index=37,30204082 SUBJECT_SAMPLE_FACTORS AMD02_010 AMD02_010 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=79; Body mass index=25,74462891 SUBJECT_SAMPLE_FACTORS AMD02_012 AMD02_012 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=20,55555556 SUBJECT_SAMPLE_FACTORS AMD02_013 AMD02_013 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=79; Body mass index=26,12009758 SUBJECT_SAMPLE_FACTORS AMD02_014 AMD02_014 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=74; Body mass index=22,6187877 SUBJECT_SAMPLE_FACTORS AMD02_015 AMD02_015 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=77; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD02_017 AMD02_017 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=87; Body mass index=27,01666219 SUBJECT_SAMPLE_FACTORS AMD02_019 AMD02_019 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=70; Body mass index=29,04958678 SUBJECT_SAMPLE_FACTORS AMD02_020 AMD02_020 AMD stage:Late | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=81; Body mass index=22,59412305 SUBJECT_SAMPLE_FACTORS AMD02_021 AMD02_021 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=89; Body mass index=22,50086505 SUBJECT_SAMPLE_FACTORS AMD02_022 AMD02_022 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=80; Body mass index=23,49075518 SUBJECT_SAMPLE_FACTORS AMD02_023 AMD02_023 AMD stage:Late | Gender:Female | Smoking:- | Cohort:Boston Age=71; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD02_025 AMD02_025 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=74; Body mass index=27,6123785 SUBJECT_SAMPLE_FACTORS AMD02_026 AMD02_026 AMD stage:Late | Gender:Female | Smoking:- | Cohort:Boston Age=87; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD02_038 AMD02_038 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=69; Body mass index=20,98025712 SUBJECT_SAMPLE_FACTORS AMD02_039 AMD02_039 AMD stage:Early | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=67; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD03_001 AMD03_001 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=62; Body mass index=21,76300728 SUBJECT_SAMPLE_FACTORS AMD03_002 AMD03_002 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=56; Body mass index=24,39189189 SUBJECT_SAMPLE_FACTORS AMD03_003 AMD03_003 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=71; Body mass index=26,1446281 SUBJECT_SAMPLE_FACTORS AMD03_004 AMD03_004 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=54; Body mass index=32,91883455 SUBJECT_SAMPLE_FACTORS AMD03_005 AMD03_005 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=51; Body mass index=33,27810651 SUBJECT_SAMPLE_FACTORS AMD03_006 AMD03_006 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=59; Body mass index=30,28798186 SUBJECT_SAMPLE_FACTORS AMD03_007 AMD03_007 AMD stage:Control | Gender:Female | Smoking:Smoker | Cohort:Boston Age=72; Body mass index=29,21519527 SUBJECT_SAMPLE_FACTORS AMD03_008 AMD03_008 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=74; Body mass index=26,51795005 SUBJECT_SAMPLE_FACTORS AMD03_009 AMD03_009 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=70; Body mass index=18,74666667 SUBJECT_SAMPLE_FACTORS AMD03_010 AMD03_010 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=68; Body mass index=24,20798898 SUBJECT_SAMPLE_FACTORS AMD03_011 AMD03_011 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=63; Body mass index=27,4609375 SUBJECT_SAMPLE_FACTORS AMD03_012 AMD03_012 AMD stage:Early | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=76; Body mass index=25,79053254 SUBJECT_SAMPLE_FACTORS AMD03_013 AMD03_013 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=67; Body mass index=33,65331 SUBJECT_SAMPLE_FACTORS AMD03_014 AMD03_014 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=67; Body mass index=27,43572084 SUBJECT_SAMPLE_FACTORS AMD03_015 AMD03_015 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=63; Body mass index=28,6191716 SUBJECT_SAMPLE_FACTORS AMD03_016 AMD03_016 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=68; Body mass index=29,1183432 SUBJECT_SAMPLE_FACTORS AMD03_017 AMD03_017 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=95; Body mass index=30,538078 SUBJECT_SAMPLE_FACTORS AMD03_018 AMD03_018 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=64; Body mass index=21,956096 SUBJECT_SAMPLE_FACTORS AMD03_019 AMD03_019 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=61; Body mass index=31,62496358 SUBJECT_SAMPLE_FACTORS AMD03_020 AMD03_020 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=81; Body mass index=23,67244898 SUBJECT_SAMPLE_FACTORS AMD03_021 AMD03_021 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=66; Body mass index=24,7456 SUBJECT_SAMPLE_FACTORS AMD03_022 AMD03_022 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=82; Body mass index=24,40972222 SUBJECT_SAMPLE_FACTORS AMD03_023 AMD03_023 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=67; Body mass index=24,12662722 SUBJECT_SAMPLE_FACTORS AMD03_024 AMD03_024 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=25,39718547 SUBJECT_SAMPLE_FACTORS AMD03_025 AMD03_025 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=64; Body mass index=39,85260771 SUBJECT_SAMPLE_FACTORS AMD03_026 AMD03_026 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=68; Body mass index=32,95114476 SUBJECT_SAMPLE_FACTORS AMD03_028 AMD03_028 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=75; Body mass index=26,3096458 SUBJECT_SAMPLE_FACTORS AMD03_029 AMD03_029 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=67; Body mass index=23,65723214 SUBJECT_SAMPLE_FACTORS AMD03_032 AMD03_032 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=75; Body mass index=25,01492195 SUBJECT_SAMPLE_FACTORS AMD03_034 AMD03_034 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=64; Body mass index=28,4946519 SUBJECT_SAMPLE_FACTORS AMD03_037 AMD03_037 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=70; Body mass index=22,67132491 SUBJECT_SAMPLE_FACTORS AMD03_038 AMD03_038 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=24,20798898 SUBJECT_SAMPLE_FACTORS AMD03_039 AMD03_039 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=66; Body mass index=24,71484375 SUBJECT_SAMPLE_FACTORS AMD03_040 AMD03_040 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=79; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD03_042 AMD03_042 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=76; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD03_043 AMD03_043 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=71; Body mass index=25,8244898 SUBJECT_SAMPLE_FACTORS AMD03_044 AMD03_044 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=73; Body mass index=25,84015963 SUBJECT_SAMPLE_FACTORS AMD03_046 AMD03_046 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=64; Body mass index=33,89118457 SUBJECT_SAMPLE_FACTORS AMD03_047 AMD03_047 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=72; Body mass index=27,85618554 SUBJECT_SAMPLE_FACTORS AMD03_050 AMD03_050 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=72; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD03_051 AMD03_051 AMD stage:Early | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=62; Body mass index=22,49453694 SUBJECT_SAMPLE_FACTORS AMD03_052 AMD03_052 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=62; Body mass index=33,46954969 SUBJECT_SAMPLE_FACTORS AMD03_053 AMD03_053 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=57; Body mass index=31,56326531 SUBJECT_SAMPLE_FACTORS AMD03_055 AMD03_055 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=32,68706747 SUBJECT_SAMPLE_FACTORS AMD03_059 AMD03_059 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=73; Body mass index=24,56060199 SUBJECT_SAMPLE_FACTORS AMD03_063 AMD03_063 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=69; Body mass index=25,03378378 SUBJECT_SAMPLE_FACTORS AMD03_067 AMD03_067 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=61; Body mass index=25,8398307 SUBJECT_SAMPLE_FACTORS AMD03_068 AMD03_068 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=74; Body mass index=23,42868478 SUBJECT_SAMPLE_FACTORS AMD03_070 AMD03_070 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=62; Body mass index=22,14033762 SUBJECT_SAMPLE_FACTORS AMD03_072 AMD03_072 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=61; Body mass index=38,96020508 SUBJECT_SAMPLE_FACTORS AMD03_073 AMD03_073 AMD stage:Control | Gender:Female | Smoking:Smoker | Cohort:Boston Age=71; Body mass index=26,62248521 SUBJECT_SAMPLE_FACTORS AMD03_074 AMD03_074 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=75; Body mass index=34,32617188 SUBJECT_SAMPLE_FACTORS AMD03_075 AMD03_075 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=69; Body mass index=23,7075977 SUBJECT_SAMPLE_FACTORS AMD03_077 AMD03_077 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=94; Body mass index=25,74462891 SUBJECT_SAMPLE_FACTORS AMD03_078 AMD03_078 AMD stage:Early | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=66; Body mass index=23,17016602 SUBJECT_SAMPLE_FACTORS AMD03_082 AMD03_082 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=69; Body mass index=25,8398307 SUBJECT_SAMPLE_FACTORS AMD03_083 AMD03_083 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=74; Body mass index=24,20798898 SUBJECT_SAMPLE_FACTORS AMD03_084 AMD03_084 AMD stage:Control | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=71; Body mass index=26,6027832 SUBJECT_SAMPLE_FACTORS AMD03_085 AMD03_085 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=72; Body mass index=25,68279164 SUBJECT_SAMPLE_FACTORS AMD03_086 AMD03_086 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Boston Age=70; Body mass index=28,6191716 SUBJECT_SAMPLE_FACTORS AMD03_087 AMD03_087 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=72; Body mass index=28,33963215 SUBJECT_SAMPLE_FACTORS AMD03_088 AMD03_088 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=69; Body mass index=26,39836735 SUBJECT_SAMPLE_FACTORS AMD03_090 AMD03_090 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=62; Body mass index=25,07056698 SUBJECT_SAMPLE_FACTORS AMD03_092 AMD03_092 AMD stage:Early | Gender:Female | Smoking:Ex smoker | Cohort:Boston Age=68; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD03_093 AMD03_093 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Boston Age=59; Body mass index=33,14316609 SUBJECT_SAMPLE_FACTORS AMD03_094 AMD03_094 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Boston Age=65; Body mass index=32,39424 SUBJECT_SAMPLE_FACTORS AMD04_002 AMD04_002 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=78; Body mass index=29,80386916 SUBJECT_SAMPLE_FACTORS AMD04_003 AMD04_003 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=26,46420267 SUBJECT_SAMPLE_FACTORS AMD04_004 AMD04_004 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=24,76756592 SUBJECT_SAMPLE_FACTORS AMD04_005 AMD04_005 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=26,57308613 SUBJECT_SAMPLE_FACTORS AMD04_006 AMD04_006 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=71; Body mass index=26,21882086 SUBJECT_SAMPLE_FACTORS AMD04_007 AMD04_007 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=92; Body mass index=28,88888889 SUBJECT_SAMPLE_FACTORS AMD04_008 AMD04_008 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=84; Body mass index=23,61275089 SUBJECT_SAMPLE_FACTORS AMD04_009 AMD04_009 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=73; Body mass index=33,69493754 SUBJECT_SAMPLE_FACTORS AMD04_010 AMD04_010 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=62; Body mass index=35,36290746 SUBJECT_SAMPLE_FACTORS AMD04_011 AMD04_011 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=26,89767019 SUBJECT_SAMPLE_FACTORS AMD04_012 AMD04_012 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=23,87279852 SUBJECT_SAMPLE_FACTORS AMD04_013 AMD04_013 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=84; Body mass index=28,57796068 SUBJECT_SAMPLE_FACTORS AMD04_014 AMD04_014 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=87; Body mass index=16,56065339 SUBJECT_SAMPLE_FACTORS AMD04_015 AMD04_015 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=21,92612582 SUBJECT_SAMPLE_FACTORS AMD04_016 AMD04_016 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD04_017 AMD04_017 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=83; Body mass index=30,02439482 SUBJECT_SAMPLE_FACTORS AMD04_018 AMD04_018 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=- SUBJECT_SAMPLE_FACTORS AMD04_019 AMD04_019 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=23,19109462 SUBJECT_SAMPLE_FACTORS AMD04_020 AMD04_020 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=40,98914463 SUBJECT_SAMPLE_FACTORS AMD04_021 AMD04_021 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=30,83289383 SUBJECT_SAMPLE_FACTORS AMD04_022 AMD04_022 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=28,44444444 SUBJECT_SAMPLE_FACTORS AMD04_023 AMD04_023 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=62; Body mass index=27,58732606 SUBJECT_SAMPLE_FACTORS AMD04_024 AMD04_024 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=34,60207612 SUBJECT_SAMPLE_FACTORS AMD04_025 AMD04_025 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=33,76038781 SUBJECT_SAMPLE_FACTORS AMD04_026 AMD04_026 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=27,91551882 SUBJECT_SAMPLE_FACTORS AMD04_027 AMD04_027 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=42,10341652 SUBJECT_SAMPLE_FACTORS AMD04_028 AMD04_028 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=26,76977989 SUBJECT_SAMPLE_FACTORS AMD04_029 AMD04_029 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=69; Body mass index=29,34443288 SUBJECT_SAMPLE_FACTORS AMD04_030 AMD04_030 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=27,734375 SUBJECT_SAMPLE_FACTORS AMD04_031 AMD04_031 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=36,97954711 SUBJECT_SAMPLE_FACTORS AMD04_032 AMD04_032 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=37,80407627 SUBJECT_SAMPLE_FACTORS AMD04_033 AMD04_033 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=84; Body mass index=32,7449283 SUBJECT_SAMPLE_FACTORS AMD04_034 AMD04_034 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=27,69928614 SUBJECT_SAMPLE_FACTORS AMD04_035 AMD04_035 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=79; Body mass index=36,03441286 SUBJECT_SAMPLE_FACTORS AMD04_037 AMD04_037 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=84; Body mass index=23,32751836 SUBJECT_SAMPLE_FACTORS AMD04_038 AMD04_038 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=92; Body mass index=21,40309156 SUBJECT_SAMPLE_FACTORS AMD04_039 AMD04_039 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=88; Body mass index=22,7189744 SUBJECT_SAMPLE_FACTORS AMD04_040 AMD04_040 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=83; Body mass index=26,953125 SUBJECT_SAMPLE_FACTORS AMD04_041 AMD04_041 AMD stage:Late | Gender:Male | Smoking:Smoker | Cohort:Coimbra Age=76; Body mass index=23,03004535 SUBJECT_SAMPLE_FACTORS AMD04_042 AMD04_042 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=91; Body mass index=30,86300683 SUBJECT_SAMPLE_FACTORS AMD04_043 AMD04_043 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=82; Body mass index=29,05328798 SUBJECT_SAMPLE_FACTORS AMD04_044 AMD04_044 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=74; Body mass index=27,13141179 SUBJECT_SAMPLE_FACTORS AMD04_048 AMD04_048 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=81; Body mass index=28,88888889 SUBJECT_SAMPLE_FACTORS AMD04_049 AMD04_049 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=28,40054796 SUBJECT_SAMPLE_FACTORS AMD04_050 AMD04_050 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=65; Body mass index=29,96878252 SUBJECT_SAMPLE_FACTORS AMD04_051 AMD04_051 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=22,22222222 SUBJECT_SAMPLE_FACTORS AMD04_054 AMD04_054 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=83; Body mass index=24,06404739 SUBJECT_SAMPLE_FACTORS AMD04_055 AMD04_055 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=26,2226847 SUBJECT_SAMPLE_FACTORS AMD04_056 AMD04_056 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=71; Body mass index=36,20361412 SUBJECT_SAMPLE_FACTORS AMD04_057 AMD04_057 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=35,19619501 SUBJECT_SAMPLE_FACTORS AMD04_058 AMD04_058 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=32,88888889 SUBJECT_SAMPLE_FACTORS AMD04_059 AMD04_059 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=27,14158239 SUBJECT_SAMPLE_FACTORS AMD04_060 AMD04_060 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=71; Body mass index=27,74474832 SUBJECT_SAMPLE_FACTORS AMD04_061 AMD04_061 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=23,91883029 SUBJECT_SAMPLE_FACTORS AMD04_062 AMD04_062 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=26,70940171 SUBJECT_SAMPLE_FACTORS AMD04_063 AMD04_063 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=89; Body mass index=28,62147037 SUBJECT_SAMPLE_FACTORS AMD04_064 AMD04_064 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=22,47658689 SUBJECT_SAMPLE_FACTORS AMD04_065 AMD04_065 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=33,73250126 SUBJECT_SAMPLE_FACTORS AMD04_066 AMD04_066 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=86; Body mass index=25,35154137 SUBJECT_SAMPLE_FACTORS AMD04_067 AMD04_067 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=25,71166208 SUBJECT_SAMPLE_FACTORS AMD04_068 AMD04_068 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=17,74622893 SUBJECT_SAMPLE_FACTORS AMD04_069 AMD04_069 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=22,58955144 SUBJECT_SAMPLE_FACTORS AMD04_070 AMD04_070 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=24,38652644 SUBJECT_SAMPLE_FACTORS AMD04_071 AMD04_071 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=65; Body mass index=27,51338489 SUBJECT_SAMPLE_FACTORS AMD04_072 AMD04_072 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=72; Body mass index=25,0995016 SUBJECT_SAMPLE_FACTORS AMD04_073 AMD04_073 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=82; Body mass index=20,57613169 SUBJECT_SAMPLE_FACTORS AMD04_074 AMD04_074 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=83; Body mass index=25,56610665 SUBJECT_SAMPLE_FACTORS AMD04_076 AMD04_076 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=75; Body mass index=23,922423 SUBJECT_SAMPLE_FACTORS AMD04_077 AMD04_077 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=81; Body mass index=30,7809074 SUBJECT_SAMPLE_FACTORS AMD04_078 AMD04_078 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=30,48780488 SUBJECT_SAMPLE_FACTORS AMD04_079 AMD04_079 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=29,61580592 SUBJECT_SAMPLE_FACTORS AMD04_080 AMD04_080 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=63; Body mass index=30,04081633 SUBJECT_SAMPLE_FACTORS AMD04_081 AMD04_081 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=61; Body mass index=25,4580659 SUBJECT_SAMPLE_FACTORS AMD04_082 AMD04_082 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=23,14049587 SUBJECT_SAMPLE_FACTORS AMD04_083 AMD04_083 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=26,9357195 SUBJECT_SAMPLE_FACTORS AMD04_084 AMD04_084 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=78; Body mass index=32,83918184 SUBJECT_SAMPLE_FACTORS AMD04_085 AMD04_085 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=26,4915082 SUBJECT_SAMPLE_FACTORS AMD04_086 AMD04_086 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=23,4375 SUBJECT_SAMPLE_FACTORS AMD04_087 AMD04_087 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=66; Body mass index=26,39797739 SUBJECT_SAMPLE_FACTORS AMD04_088 AMD04_088 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=22,2136785 SUBJECT_SAMPLE_FACTORS AMD04_089 AMD04_089 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=24,30461788 SUBJECT_SAMPLE_FACTORS AMD04_090 AMD04_090 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=27,82931354 SUBJECT_SAMPLE_FACTORS AMD04_091 AMD04_091 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=35,33859303 SUBJECT_SAMPLE_FACTORS AMD04_092 AMD04_092 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=30,48315806 SUBJECT_SAMPLE_FACTORS AMD04_093 AMD04_093 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=21,36752137 SUBJECT_SAMPLE_FACTORS AMD04_094 AMD04_094 AMD stage:Intermediate | Gender:Female | Smoking:Ex smoker | Cohort:Coimbra Age=80; Body mass index=28,5075216 SUBJECT_SAMPLE_FACTORS AMD04_095 AMD04_095 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=33,29864724 SUBJECT_SAMPLE_FACTORS AMD04_096 AMD04_096 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=85; Body mass index=23,45856238 SUBJECT_SAMPLE_FACTORS AMD04_097 AMD04_097 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=89; Body mass index=29,41073492 SUBJECT_SAMPLE_FACTORS AMD04_098 AMD04_098 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=72; Body mass index=29,40759637 SUBJECT_SAMPLE_FACTORS AMD04_099 AMD04_099 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=60; Body mass index=28,47988608 SUBJECT_SAMPLE_FACTORS AMD04_100 AMD04_100 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=23,66524436 SUBJECT_SAMPLE_FACTORS AMD04_101 AMD04_101 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=19,53125 SUBJECT_SAMPLE_FACTORS AMD04_102 AMD04_102 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=25,97011555 SUBJECT_SAMPLE_FACTORS AMD04_103 AMD04_103 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=28,22838647 SUBJECT_SAMPLE_FACTORS AMD04_104 AMD04_104 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=79; Body mass index=27,58732606 SUBJECT_SAMPLE_FACTORS AMD04_105 AMD04_105 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=85; Body mass index=31,22945431 SUBJECT_SAMPLE_FACTORS AMD04_106 AMD04_106 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=27,99036281 SUBJECT_SAMPLE_FACTORS AMD04_108 AMD04_108 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=65; Body mass index=31,18458712 SUBJECT_SAMPLE_FACTORS AMD04_109 AMD04_109 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=31,46836966 SUBJECT_SAMPLE_FACTORS AMD04_110 AMD04_110 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=30,02150189 SUBJECT_SAMPLE_FACTORS AMD04_111 AMD04_111 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=34,47809627 SUBJECT_SAMPLE_FACTORS AMD04_112 AMD04_112 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=68; Body mass index=22,32142857 SUBJECT_SAMPLE_FACTORS AMD04_113 AMD04_113 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=35,05563176 SUBJECT_SAMPLE_FACTORS AMD04_114 AMD04_114 AMD stage:Late | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=79; Body mass index=33,91251334 SUBJECT_SAMPLE_FACTORS AMD04_115 AMD04_115 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=25,20398137 SUBJECT_SAMPLE_FACTORS AMD04_116 AMD04_116 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=84; Body mass index=26,91272587 SUBJECT_SAMPLE_FACTORS AMD04_117 AMD04_117 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=25,1486054 SUBJECT_SAMPLE_FACTORS AMD04_118 AMD04_118 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=61; Body mass index=30,79584775 SUBJECT_SAMPLE_FACTORS AMD04_119 AMD04_119 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=77; Body mass index=23,14049587 SUBJECT_SAMPLE_FACTORS AMD04_120 AMD04_120 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=24,23822715 SUBJECT_SAMPLE_FACTORS AMD04_121 AMD04_121 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=60; Body mass index=22,03172568 SUBJECT_SAMPLE_FACTORS AMD04_122 AMD04_122 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=29,17488494 SUBJECT_SAMPLE_FACTORS AMD04_123 AMD04_123 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=23,55555556 SUBJECT_SAMPLE_FACTORS AMD04_124 AMD04_124 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=32,8731098 SUBJECT_SAMPLE_FACTORS AMD04_125 AMD04_125 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=78; Body mass index=29,6875 SUBJECT_SAMPLE_FACTORS AMD04_126 AMD04_126 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=19,07183725 SUBJECT_SAMPLE_FACTORS AMD04_128 AMD04_128 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=85; Body mass index=22,94213045 SUBJECT_SAMPLE_FACTORS AMD04_129 AMD04_129 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=25,06574622 SUBJECT_SAMPLE_FACTORS AMD04_130 AMD04_130 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=75; Body mass index=28,25096981 SUBJECT_SAMPLE_FACTORS AMD04_131 AMD04_131 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=27,73229978 SUBJECT_SAMPLE_FACTORS AMD04_132 AMD04_132 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=80; Body mass index=25,63691716 SUBJECT_SAMPLE_FACTORS AMD04_133 AMD04_133 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=79; Body mass index=28,30533236 SUBJECT_SAMPLE_FACTORS AMD04_134 AMD04_134 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=84; Body mass index=37,38570335 SUBJECT_SAMPLE_FACTORS AMD04_135 AMD04_135 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=23,4375 SUBJECT_SAMPLE_FACTORS AMD04_136 AMD04_136 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=75; Body mass index=29,21010994 SUBJECT_SAMPLE_FACTORS AMD04_137 AMD04_137 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=65; Body mass index=27,94309769 SUBJECT_SAMPLE_FACTORS AMD04_138 AMD04_138 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=29,96878252 SUBJECT_SAMPLE_FACTORS AMD04_139 AMD04_139 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=24,86395196 SUBJECT_SAMPLE_FACTORS AMD04_140 AMD04_140 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=30,73060942 SUBJECT_SAMPLE_FACTORS AMD04_141 AMD04_141 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=29,96878252 SUBJECT_SAMPLE_FACTORS AMD04_142 AMD04_142 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=28,99930748 SUBJECT_SAMPLE_FACTORS AMD04_143 AMD04_143 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=71; Body mass index=28,3446712 SUBJECT_SAMPLE_FACTORS AMD04_144 AMD04_144 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=24,30461788 SUBJECT_SAMPLE_FACTORS AMD04_145 AMD04_145 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=20,54419284 SUBJECT_SAMPLE_FACTORS AMD04_146 AMD04_146 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=23,37257618 SUBJECT_SAMPLE_FACTORS AMD04_147 AMD04_147 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=73; Body mass index=26,81359045 SUBJECT_SAMPLE_FACTORS AMD04_148 AMD04_148 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=22,80601728 SUBJECT_SAMPLE_FACTORS AMD04_149 AMD04_149 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=20,17325264 SUBJECT_SAMPLE_FACTORS AMD04_150 AMD04_150 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=29,70564407 SUBJECT_SAMPLE_FACTORS AMD04_151 AMD04_151 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=27,43484225 SUBJECT_SAMPLE_FACTORS AMD04_152 AMD04_152 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=30,22222222 SUBJECT_SAMPLE_FACTORS AMD04_153 AMD04_153 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=63; Body mass index=28,99930748 SUBJECT_SAMPLE_FACTORS AMD04_154 AMD04_154 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=81; Body mass index=26,44897959 SUBJECT_SAMPLE_FACTORS AMD04_155 AMD04_155 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=27,77226741 SUBJECT_SAMPLE_FACTORS AMD04_156 AMD04_156 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=63; Body mass index=24,61810377 SUBJECT_SAMPLE_FACTORS AMD04_157 AMD04_157 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=24,14151925 SUBJECT_SAMPLE_FACTORS AMD04_158 AMD04_158 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=25,71100827 SUBJECT_SAMPLE_FACTORS AMD04_159 AMD04_159 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=32,45567772 SUBJECT_SAMPLE_FACTORS AMD04_160 AMD04_160 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=24,91990032 SUBJECT_SAMPLE_FACTORS AMD04_161 AMD04_161 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=25,2825699 SUBJECT_SAMPLE_FACTORS AMD04_162 AMD04_162 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=23,30668005 SUBJECT_SAMPLE_FACTORS AMD04_163 AMD04_163 AMD stage:Intermediate | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=81; Body mass index=24,08822312 SUBJECT_SAMPLE_FACTORS AMD04_164 AMD04_164 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=24,52434635 SUBJECT_SAMPLE_FACTORS AMD04_165 AMD04_165 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=90; Body mass index=24,12174905 SUBJECT_SAMPLE_FACTORS AMD04_166 AMD04_166 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=22,98742728 SUBJECT_SAMPLE_FACTORS AMD04_167 AMD04_167 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=22,86236854 SUBJECT_SAMPLE_FACTORS AMD04_168 AMD04_168 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=78; Body mass index=23,53036634 SUBJECT_SAMPLE_FACTORS AMD04_169 AMD04_169 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=36,62851197 SUBJECT_SAMPLE_FACTORS AMD04_170 AMD04_170 AMD stage:Early | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=30,58802045 SUBJECT_SAMPLE_FACTORS AMD04_171 AMD04_171 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=29,06976744 SUBJECT_SAMPLE_FACTORS AMD04_172 AMD04_172 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=86; Body mass index=28,3446712 SUBJECT_SAMPLE_FACTORS AMD04_173 AMD04_173 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=22,40587695 SUBJECT_SAMPLE_FACTORS AMD04_174 AMD04_174 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=29,00059488 SUBJECT_SAMPLE_FACTORS AMD04_175 AMD04_175 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=75; Body mass index=25,6311675 SUBJECT_SAMPLE_FACTORS AMD04_176 AMD04_176 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=28,19428425 SUBJECT_SAMPLE_FACTORS AMD04_177 AMD04_177 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=36,03441286 SUBJECT_SAMPLE_FACTORS AMD04_178 AMD04_178 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=80; Body mass index=23,8330046 SUBJECT_SAMPLE_FACTORS AMD04_179 AMD04_179 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=30,22222222 SUBJECT_SAMPLE_FACTORS AMD04_180 AMD04_180 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=30,22222222 SUBJECT_SAMPLE_FACTORS AMD04_181 AMD04_181 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=32,4547169 SUBJECT_SAMPLE_FACTORS AMD04_182 AMD04_182 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=20,96436059 SUBJECT_SAMPLE_FACTORS AMD04_183 AMD04_183 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=18,28989483 SUBJECT_SAMPLE_FACTORS AMD04_184 AMD04_184 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=86; Body mass index=28,39506173 SUBJECT_SAMPLE_FACTORS AMD04_185 AMD04_185 AMD stage:Late | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=87; Body mass index=32,88140174 SUBJECT_SAMPLE_FACTORS AMD04_186 AMD04_186 AMD stage:Late | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=79; Body mass index=23,71184463 SUBJECT_SAMPLE_FACTORS AMD04_188 AMD04_188 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=32,05128205 SUBJECT_SAMPLE_FACTORS AMD04_189 AMD04_189 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=85; Body mass index=23,61275089 SUBJECT_SAMPLE_FACTORS AMD04_190 AMD04_190 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=33,91251334 SUBJECT_SAMPLE_FACTORS AMD05_001 AMD05_001 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=23,33768443 SUBJECT_SAMPLE_FACTORS AMD05_002 AMD05_002 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=65; Body mass index=31,98054142 SUBJECT_SAMPLE_FACTORS AMD05_003 AMD05_003 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=65; Body mass index=22,14034613 SUBJECT_SAMPLE_FACTORS AMD05_004 AMD05_004 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=65; Body mass index=27,28174603 SUBJECT_SAMPLE_FACTORS AMD05_005 AMD05_005 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=32,87197232 SUBJECT_SAMPLE_FACTORS AMD05_006 AMD05_006 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=24,77679525 SUBJECT_SAMPLE_FACTORS AMD05_007 AMD05_007 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=28,44444444 SUBJECT_SAMPLE_FACTORS AMD05_008 AMD05_008 AMD stage:Early | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=72; Body mass index=24,33747972 SUBJECT_SAMPLE_FACTORS AMD05_010 AMD05_010 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=71; Body mass index=26,2335558 SUBJECT_SAMPLE_FACTORS AMD05_011 AMD05_011 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=23,53304271 SUBJECT_SAMPLE_FACTORS AMD05_012 AMD05_012 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=33,28402367 SUBJECT_SAMPLE_FACTORS AMD05_013 AMD05_013 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=74; Body mass index=25,82644628 SUBJECT_SAMPLE_FACTORS AMD05_014 AMD05_014 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=27,29322416 SUBJECT_SAMPLE_FACTORS AMD05_015 AMD05_015 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=38,36873541 SUBJECT_SAMPLE_FACTORS AMD05_016 AMD05_016 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=33,22653376 SUBJECT_SAMPLE_FACTORS AMD05_017 AMD05_017 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=29,72839061 SUBJECT_SAMPLE_FACTORS AMD05_019 AMD05_019 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=27,18163009 SUBJECT_SAMPLE_FACTORS AMD05_020 AMD05_020 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=30,35925114 SUBJECT_SAMPLE_FACTORS AMD05_021 AMD05_021 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=71; Body mass index=28,06183115 SUBJECT_SAMPLE_FACTORS AMD05_022 AMD05_022 AMD stage:Intermediate | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=19,95728441 SUBJECT_SAMPLE_FACTORS AMD05_023 AMD05_023 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=26,25958475 SUBJECT_SAMPLE_FACTORS AMD05_024 AMD05_024 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=79; Body mass index=32,65306122 SUBJECT_SAMPLE_FACTORS AMD05_025 AMD05_025 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=23,11111111 SUBJECT_SAMPLE_FACTORS AMD05_027 AMD05_027 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=78; Body mass index=35,11111111 SUBJECT_SAMPLE_FACTORS AMD05_028 AMD05_028 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=71; Body mass index=18,73048907 SUBJECT_SAMPLE_FACTORS AMD05_029 AMD05_029 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=25,39021852 SUBJECT_SAMPLE_FACTORS AMD05_030 AMD05_030 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=26,7299275 SUBJECT_SAMPLE_FACTORS AMD05_031 AMD05_031 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=74; Body mass index=19,97918835 SUBJECT_SAMPLE_FACTORS AMD05_032 AMD05_032 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=73; Body mass index=25,76571346 SUBJECT_SAMPLE_FACTORS AMD05_033 AMD05_033 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=65; Body mass index=23,53304271 SUBJECT_SAMPLE_FACTORS AMD05_034 AMD05_034 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=26,91272587 SUBJECT_SAMPLE_FACTORS AMD05_035 AMD05_035 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=29,31985649 SUBJECT_SAMPLE_FACTORS AMD05_036 AMD05_036 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=72; Body mass index=30,40762656 SUBJECT_SAMPLE_FACTORS AMD05_037 AMD05_037 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=75; Body mass index=26,10656224 SUBJECT_SAMPLE_FACTORS AMD05_038 AMD05_038 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=29,51593861 SUBJECT_SAMPLE_FACTORS AMD05_041 AMD05_041 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=63; Body mass index=20,93212012 SUBJECT_SAMPLE_FACTORS AMD05_042 AMD05_042 AMD stage:Early | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=82; Body mass index=23,42355741 SUBJECT_SAMPLE_FACTORS AMD05_043 AMD05_043 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=75; Body mass index=34,24657534 SUBJECT_SAMPLE_FACTORS AMD05_044 AMD05_044 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=22,47658689 SUBJECT_SAMPLE_FACTORS AMD05_046 AMD05_046 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=76; Body mass index=29,43213296 SUBJECT_SAMPLE_FACTORS AMD05_047 AMD05_047 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=25,45235781 SUBJECT_SAMPLE_FACTORS AMD05_048 AMD05_048 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=20,703125 SUBJECT_SAMPLE_FACTORS AMD05_049 AMD05_049 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=70; Body mass index=30,40529253 SUBJECT_SAMPLE_FACTORS AMD05_051 AMD05_051 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=62; Body mass index=26,85440557 SUBJECT_SAMPLE_FACTORS AMD05_052 AMD05_052 AMD stage:Intermediate | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=75; Body mass index=32,03895937 SUBJECT_SAMPLE_FACTORS AMD05_053 AMD05_053 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=72; Body mass index=24,93372049 SUBJECT_SAMPLE_FACTORS AMD05_058 AMD05_058 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=77; Body mass index=17,62538055 SUBJECT_SAMPLE_FACTORS AMD05_059 AMD05_059 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=26,2226847 SUBJECT_SAMPLE_FACTORS AMD05_061 AMD05_061 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=36,57133465 SUBJECT_SAMPLE_FACTORS AMD05_064 AMD05_064 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=64; Body mass index=29,64268547 SUBJECT_SAMPLE_FACTORS AMD05_065 AMD05_065 AMD stage:Control | Gender:Male | Smoking:Non smoker | Cohort:Coimbra Age=63; Body mass index=34,765625 SUBJECT_SAMPLE_FACTORS AMD05_068 AMD05_068 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=65; Body mass index=24,48979592 SUBJECT_SAMPLE_FACTORS AMD05_069 AMD05_069 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=68; Body mass index=28,44444444 SUBJECT_SAMPLE_FACTORS AMD05_072 AMD05_072 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=24,52434635 SUBJECT_SAMPLE_FACTORS AMD05_073 AMD05_073 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=28,76186998 SUBJECT_SAMPLE_FACTORS AMD05_074 AMD05_074 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=66; Body mass index=22,54657648 SUBJECT_SAMPLE_FACTORS AMD05_076 AMD05_076 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=67; Body mass index=23,37257618 SUBJECT_SAMPLE_FACTORS AMD05_080 AMD05_080 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=65; Body mass index=34,72222222 SUBJECT_SAMPLE_FACTORS AMD05_081 AMD05_081 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=65; Body mass index=26,953125 SUBJECT_SAMPLE_FACTORS AMD05_082 AMD05_082 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=71; Body mass index=31,56167151 SUBJECT_SAMPLE_FACTORS AMD05_083 AMD05_083 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=78; Body mass index=28,9340689 SUBJECT_SAMPLE_FACTORS AMD05_084 AMD05_084 AMD stage:Control | Gender:Male | Smoking:Ex smoker | Cohort:Coimbra Age=71; Body mass index=27,734375 SUBJECT_SAMPLE_FACTORS AMD05_085 AMD05_085 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=69; Body mass index=23,01117686 SUBJECT_SAMPLE_FACTORS AMD05_091 AMD05_091 AMD stage:Control | Gender:Female | Smoking:Non smoker | Cohort:Coimbra Age=59; Body mass index=25,46198063 #COLLECTION CO:COLLECTION_SUMMARY For all participants, fasting blood samples were collected into sodium-heparin CO:COLLECTION_SUMMARY tubes, and centrifuged within 30 min (1500 rpm, 10 min, 20ºC). Plasma aliquots CO:COLLECTION_SUMMARY of 1.5 mL (MEE) and 5 mL (FMUC/AIBILI) were transferred into sterile cryovials CO:COLLECTION_SUMMARY and stored at -80ºC. Plasma samples from MEE were shipped to Portugal for CO:COLLECTION_SUMMARY metabolomic profiling in dry ice (through TNT Express, USA, INC). Samples CO:COLLECTION_SUMMARY arrived frozen in less than 48 hours and were immediately stored at -80ºC until CO:COLLECTION_SUMMARY NMR analysis. CO:SAMPLE_TYPE Blood plasma CO:COLLECTION_METHOD For all participants, fasting blood samples were collected into sodium-heparin CO:COLLECTION_METHOD tubes, and centrifuged within 30 min (1500 rpm, 10 min, 20ºC). Plasma aliquots CO:COLLECTION_METHOD of 1.5 mL (MEE) and 5 mL (FMUC/AIBILI) were transferred into sterile cryovials CO:COLLECTION_METHOD and stored at -80ºC. Plasma samples from MEE were shipped to Portugal for CO:COLLECTION_METHOD metabolomic profiling in dry ice (through TNT Express, USA, INC). Samples CO:COLLECTION_METHOD arrived frozen in less than 48 hours and were immediately stored at -80ºC until CO:COLLECTION_METHOD NMR analysis. CO:COLLECTION_LOCATION Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, US; CO:COLLECTION_LOCATION Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Association for CO:COLLECTION_LOCATION Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, CO:COLLECTION_LOCATION Portugal. CO:COLLECTION_FREQUENCY one collection CO:VOLUMEORAMOUNT_COLLECTED 9 tp 10 mL CO:STORAGE_CONDITIONS Plasma aliquots were stored at -80ºC. Plasma samples from MEE were shipped to CO:STORAGE_CONDITIONS Portugal for metabolomic profiling in dry ice (through TNT Express, USA, INC). CO:STORAGE_CONDITIONS Samples arrived frozen in less than 48 hours and were immediately stored at CO:STORAGE_CONDITIONS -80ºC until NMR analysis. CO:COLLECTION_VIALS sodium-heparin tubes CO:STORAGE_VIALS sterile cryovials CO:COLLECTION_TUBE_TEMP room temperature CO:ADDITIVES No CO:BLOOD_SERUM_OR_PLASMA Yes, blood samples were collected, which were then centrifuged to obtain plasma #TREATMENT TR:TREATMENT_SUMMARY No treatments were applied in the context of this project #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Prior to analysis, plasma samples were thawed at room temperature and SP:SAMPLEPREP_SUMMARY homogenized in a vortex mixer. Then, 400 µl of saline solution (NaCl 0.9% in SP:SAMPLEPREP_SUMMARY 10% D2O) were added to 200 µl of sample. After centrifugation (4500 g, 5min, SP:SAMPLEPREP_SUMMARY 25ºC), 550 µl of each sample was transferred to a 5 mm NMR tube. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE - CH:INSTRUMENT_NAME - CH:COLUMN_NAME - #ANALYSIS AN:ANALYSIS_TYPE NMR AN:LABORATORY_NAME University of Aveiro AN:OPERATOR_NAME Daniela Duarte and Ana Sofia Martins AN:SOFTWARE_VERSION Topsoin 3.2 AN:ACQUISITION_DATE From June 2015 to September 2017 AN:DATA_FORMAT NMR spectra converted into excel #NMR NM:INSTRUMENT_NAME Bruker Avance DRX 500 spectrometer NM:INSTRUMENT_TYPE FT-NMR NM:NMR_EXPERIMENT_TYPE 1D-1H NM:SPECTROMETER_FREQUENCY 500 MHz NM:NMR_PROBE TXI NM:NMR_SOLVENT H2O+D2O (10%)_salt NM:NMR_TUBE_SIZE 5 mm NM:SHIMMING_METHOD Automated NM:PULSE_SEQUENCE cpmgpr1d and ledbpgp2s1dpr NM:WATER_SUPPRESSION Yes NM:PULSE_WIDTH 7 us NM:RECEIVER_GAIN 128 and 203 NM:CHEMICAL_SHIFT_REF_CPD glucose NM:TEMPERATURE 300 K NM:NUMBER_OF_SCANS 256 and 128 NM:DUMMY_SCANS 4 NM:ACQUISITION_TIME 1.59 s NM:RELAXATION_DELAY 4 s NM:SPECTRAL_WIDTH 20,6557 Hz NM:NUM_DATA_POINTS_ACQUIRED 32 k NM:REAL_DATA_POINTS 32 k NM:LINE_BROADENING 0,3 Hz NM:ZERO_FILLING 64 k NM:BASELINE_CORRECTION_METHOD manual NM:CHEMICAL_SHIFT_REF_STD glucose (5.23 ppm) NM:BINNED_INCREMENT full resolution NM:BINNED_DATA_EXCLUDED_RANGE 4.50-5.15 ppm NM:NM_RESULTS_FILE ST000590_AN000905_Results.zip #END