#METABOLOMICS WORKBENCH araskind_20170619_183051 DATATRACK_ID:1056 STUDY_ID:ST000752 ANALYSIS_ID:AN001180 PROJECT_ID:PR000542 VERSION 1 CREATED_ON July 4, 2017, 1:43 pm #PROJECT PR:PROJECT_TITLE Thermal Modalities Study PR:PROJECT_TYPE MS analysis PR:PROJECT_SUMMARY This study is looking at the effect of cooling on muscle tissue metabolism PR:INSTITUTE University of Michigan PR:DEPARTMENT Orthopaedic Surgery PR:LABORATORY Mendias Lab PR:LAST_NAME Mendias PR:FIRST_NAME Christopher PR:ADDRESS Ann Arbor, MI PR:EMAIL cmendias@umich.edu PR:PHONE 734-764-3250 #STUDY ST:STUDY_TITLE Effect of cooling on muscle tissue metabolism ST:STUDY_TYPE MS analysis ST:STUDY_SUMMARY Thermal modalities are commonly used in sports medicine to affect tissue ST:STUDY_SUMMARY healing. Cold therapy is commonly used modalities, but the metabolic changes to ST:STUDY_SUMMARY muscle after cooling are not known. The objective of this study is to look at ST:STUDY_SUMMARY the effect of cooling on muscle metabolites and gene expression. There are a ST:STUDY_SUMMARY total of 8 subjects in the study. Each subject had an ice cup cryotherapy ST:STUDY_SUMMARY treatment ("cool" samples) to one leg for 15 minutes, and the other leg served ST:STUDY_SUMMARY as the control ("cntrl" samples). Two hours after the application of ST:STUDY_SUMMARY cryotherapy, a biopsy was taken from each thigh muscle. Muscle was minced with ST:STUDY_SUMMARY scissors and quickly snap frozen in liquid nitrogen. ST:INSTITUTE University of Michigan ST:DEPARTMENT Biomedical Research Core Facilities ST:LABORATORY Metabolomics core ST:LAST_NAME Kachman ST:FIRST_NAME Maureen ST:ADDRESS 6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714 ST:EMAIL mkachman@med.umich.edu ST:PHONE (734) 232-8175 ST:NUM_GROUPS 10 ST:TOTAL_SUBJECTS 8 ST:STUDY_COMMENTS We would like to run the TCA Plus Analysis on each of the samples. For the ST:STUDY_COMMENTS statistical analysis, we would normalize the cool side to the ctrl side, and ST:STUDY_COMMENTS look at the relative change in metabolite abundance as a result of the cooling ST:STUDY_COMMENTS procedure. only used in sports medicine to affect tissue healing. #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS SU0014908 S00023215 Temperature:Control Subject=1 SUBJECT_SAMPLE_FACTORS SU0014908 S00023216 Temperature:Cooled Subject=1 SUBJECT_SAMPLE_FACTORS SU0014909 S00023217 Temperature:Control Subject=2 SUBJECT_SAMPLE_FACTORS SU0014909 S00023218 Temperature:Cooled Subject=2 SUBJECT_SAMPLE_FACTORS SU0014910 S00023219 Temperature:Control Subject=3 SUBJECT_SAMPLE_FACTORS SU0014910 S00023220 Temperature:Cooled Subject=3 SUBJECT_SAMPLE_FACTORS SU0014911 S00023221 Temperature:Control Subject=4 SUBJECT_SAMPLE_FACTORS SU0014911 S00023222 Temperature:Cooled Subject=4 SUBJECT_SAMPLE_FACTORS SU0014912 S00023223 Temperature:Control Subject=5 SUBJECT_SAMPLE_FACTORS SU0014912 S00023224 Temperature:Cooled Subject=5 SUBJECT_SAMPLE_FACTORS SU0014913 S00023225 Temperature:Control Subject=6 SUBJECT_SAMPLE_FACTORS SU0014913 S00023226 Temperature:Cooled Subject=6 SUBJECT_SAMPLE_FACTORS SU0014914 S00023227 Temperature:Control Subject=7 SUBJECT_SAMPLE_FACTORS SU0014914 S00023228 Temperature:Cooled Subject=7 SUBJECT_SAMPLE_FACTORS SU0014915 S00023229 Temperature:Control Subject=8 SUBJECT_SAMPLE_FACTORS SU0014915 S00023230 Temperature:Cooled Subject=8 #COLLECTION CO:COLLECTION_SUMMARY - #TREATMENT TR:TREATMENT_SUMMARY - #SAMPLEPREP SP:SAMPLEPREP_SUMMARY - SP:SAMPLEPREP_PROTOCOL_FILENAME A011 - Glycolysis-TCA-nucleotides.pdf #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Agilent CH:COLUMN_NAME Phenomenex Luna NH2 (150 x 1mm, 3um) #ANALYSIS AN:ANALYSIS_TYPE MS AN:ANALYSIS_PROTOCOL_FILE A011 - Glycolysis-TCA-nucleotides.pdf #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME Agilent 6520B QTOF MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE ESI MS:ION_MODE NEGATIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS nmol/mg MS_METABOLITE_DATA_START Samples S00023215 S00023216 S00023217 S00023218 S00023219 S00023220 S00023221 S00023222 S00023223 S00023224 S00023225 S00023226 S00023227 S00023228 S00023229 S00023230 Factors Temperature:Control Temperature:Cooled Temperature:Control Temperature:Cooled Temperature:Control Temperature:Cooled Temperature:Control Temperature:Cooled Temperature:Control Temperature:Cooled Temperature:Control Temperature:Cooled Temperature:Control Temperature:Cooled Temperature:Control Temperature:Cooled PHOSPHOENOLPYRUVATE 70741.79313 13395.53717 0 24197.34206 0 3859.157887 0 0 0 0 0 15952.41669 0 0 8418.77942 0 GLUCONIC ACID 1531831.112 1701918.566 1597063.927 2085433.332 1693283.748 4191828.811 1911684.067 2551770.163 1975005.173 3061108.445 1666924.37 2579937.76 2393763.176 1419056.021 2905784.03 4303091.676 TAURINE 137498992.5 128251072.7 153601902.1 108492245.5 126746462.8 144206437.7 96930794.63 116303401 92918888.06 91900415.78 169093318.2 145433288.2 161784501.3 96143212.82 189905234.4 161991416.1 URIC ACID 707856.9115 989179.2713 318196.5505 1568698.644 0 105922.4805 935490.526 1598001.92 745497.0015 775802.5946 1668164.229 0 0 0 995887.8541 1709601.513 D-ERYTHROSE 4-PHOSPHATE 3.94646415 5.227754209 3.417357853 1.933654392 3.312279724 4.009106573 3.87202955 5.005469238 3.25329155 2.858650942 3.227766298 2.545112891 4.389657105 2.300372952 3.694400552 3.074067477 GLUTATHIONE 9535987.256 11494451.4 7132026.816 6458720.08 3017549.027 4371290.083 7578025.746 8242502.117 5121053.833 6426650.572 6374973.708 1073545.495 7894797.608 5344673.334 7034977.766 9035557.215 L-PROLINE 4725292.652 4647278.074 3173106.757 2489410.734 4623114.194 4816702.213 7779205.205 8799992.587 6924067.988 5503043.196 4606662.275 4676458.243 5688905.15 3553363.16 9207906.834 7932848.664 BETA-NAD+ .061383361 .094627856 .027148456 .016684607 .045028167 .011073473 .036870057 .027876861 .063795149 .035547528 .046566157 .108090497 .014606847 .077303078 .095719458 .108653926 COENZYME II .008207605 .006789212 .003144356 .002838797 .004040534 .002803397 .004234083 .00529144 .004647351 .003184894 .006466174 .005539331 .002119936 .004692058 .009093466 .010877024 SEDOHEPTULOSE 7-PHOSPHATE .00386658 .011162527 .002623441 .006653065 .002408949 .005335913 .003042897 .005404464 .003185302 .002275792 .007054431 .005453507 .008057386 .0035053 .003647809 .003262038 UDP-GLUCURONIC ACID 68603.37647 85661.18023 85357.97552 56951.34225 96816.55344 123827.2541 76253.68427 105532.7252 56404.46219 75633.62157 47738.01557 21234.36121 95395.72224 65256.22889 53907.305 40893.74097 ACETYLPHOSPHATE 703629.8013 931508.1627 864705.8876 584002.9672 788071.1567 965763.9532 809912.5349 976004.0424 614830.8979 708822.2772 572674.5113 372099.6952 1106289.448 616865.0631 639365.9156 566387.6464 D-FRUCTOSE, 1,6-BIS(DIHYDROGEN PHOSPHATE) 1.269638109 .947416422 3.337867273 2.581308631 2.3273682 5.461056018 2.510364683 3.340046292 1.443928121 1.403804465 2.041791959 .781649437 1.843231206 .798620372 1.499817772 2.122147139 NADP-REDUCED 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 CITRIC ACID .081620299 .11481453 .066870211 .101163017 .152750345 .069848955 .08596618 .078378802 .162370123 .104068247 .182294429 .212417167 .063425171 .090186501 .260857311 .265800033 L-GLUTAMIC ACID 17459828.82 16843623.61 10149468.96 7286836.229 8824785.57 8436537.362 11981469.52 8969593.155 9794985.456 7829532.682 11057681.35 11592992.37 8756217.204 11439337.45 15770954.57 16199855.27 NADH .034282857 .045283412 .008360933 .030189146 0 .004401122 .07944624 .143262691 .078200061 .039511913 .176692706 0 0 0 .037573807 .07442283 N-ACETYL-D-GLUCOSAMINE 1-PHOSPHATE 37925.38273 28119.64926 20047.12589 22685.1036 23473.67296 46694.73976 17278.83262 25181.83896 21670.12406 25857.9761 26898.20869 23908.94526 17796.9872 13791.81816 18405.796 20417.58501 OLEIC ACID 10224351.55 5485663.574 7094282.199 43859438.59 10014898.05 15093749.55 8136230.527 8432581.76 6889990.025 8694441.226 11515655.96 10301975.93 11084346.57 2727270.457 6193337.243 7449234.296 UDP-N-ACETYLGLUCOSAMINE 163828.9171 170186.6827 187268.7568 188983.4787 189742.2424 165660.0403 216570.9559 219334.7691 274690.6503 220913.7024 259759.821 209818.5582 205946.7697 197017.7387 293444.2455 297180.8394 FAD .010692553 .009597777 .007229298 .006092064 .00745574 .008345892 .007812437 .008195953 .007575984 .005975604 .008802507 .007117713 .006868486 .005984764 .013238667 .012357041 MALIC ACID 2.263102004 2.352403016 .894772328 .684167038 .761412689 .583195476 .914080484 .912978189 1.509675156 .758849478 2.525787507 3.076414962 1.037029319 .928601608 3.834833377 2.94478518 STEARIC ACID 26002928.58 11942996.39 18096076.86 22362915.71 17565353.73 20644341.54 17574238.86 11305046.45 47312709.37 18830138.67 17986435.9 12421747.61 14788248.16 19139037.17 13148597.54 15636445.65 UDPGLUCOSE 167031.8341 123524.9409 234131.8901 230856.1038 157811.447 150836.3994 179773.8529 156106.104 117146.2187 119606.0705 137608.7002 104752.4337 53258.46234 94004.04095 181702.8394 228924.0573 D-GLUCOSE 8141928.595 7288652.165 5929344.491 4537748.678 7745280.675 7677928.711 11820398.81 11016153.06 7569637.054 5969750.421 5661331.869 4969892.413 6392951.974 3517242.697 7574665.15 6572776.008 CREATINE 9842330.303 12296697.36 11761982.28 8433587.698 9515237.365 10405110.39 9686630.993 10895014.93 11280909.35 11835657.03 10809386.08 10715603.75 16298415.91 9290920.692 14608539.23 13138323.6 L-ALANINE 10268416.93 11932901.59 11718691.21 8476087.207 8431436.398 10583297.74 10060397.22 11541251.8 8850718.045 9321992.229 10231040.42 9446518.382 13586062.55 7869148.654 12089928.82 11029641.97 ADENOSINE TRIPHOSPHATE 2.519619294 2.556889038 .577001218 1.089223982 1.759796408 .392326337 2.026415602 1.411050083 2.316626289 1.5867462 2.261485404 2.264618889 .069146763 1.926661601 3.712126911 4.320597983 ROBISON ESTER 5.179479675 7.504835951 25088139.83 15168928.77 4.554954998 29852591.46 5.195052378 27610989.38 4.079391887 4.057755034 3.862134473 9504969.474 31555548.14 17374348.24 19229887.5 14868090.53 L-ASPARTIC ACID 215330.6717 193939.6808 72083.51394 83295.12708 96600.12092 49561.86956 74855.68559 49304.19533 303112.1051 156063.5806 189004.812 333561.3473 405425.1837 240002.1807 480792.9223 632181.5465 L-GLUTAMINE 100648308.7 114430473.9 66228804.52 53948703.03 103044920.7 97935475.19 102601951.6 100986036.8 119169712.5 108061284.2 97257878.82 90136797.55 112569634.2 82095377.86 117065563.7 103257849.2 L-LYSINE 2073026.681 2423707.959 2350997.324 1748243.69 1473926.971 1569881.99 2650758.87 2085700.752 1534014.065 1395460.554 1107358.854 1497227.064 3631516.291 2214714.154 1974396.78 1757700.552 SUCROSE .169419199 .216134305 .295964022 .064927787 .047655018 .095066608 .086963055 .148015296 .080620477 .055596389 .105486143 .11323052 .389051843 .075397519 .176821841 .172603545 INOSINE 1219767.173 309446.9936 6504446.633 3244489.342 1745642.786 8137632.175 906268.5181 2087476.862 350023.2193 995467.5702 1439442.949 864659.9799 11292926.94 654406.8197 1060922.878 766685.2139 ADENOSINE 5'-DIPHOSPHATE .233946275 .239159323 .235614242 .210016908 .166813823 .325091614 .240027999 .227609424 .097709442 .095601901 .159951895 .109053017 .247691503 .100201306 .157065873 .178207686 URIDYLIC ACID 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 URIDINE 5'-DIPHOSPHATE 11868.66928 13643.7451 45007.96193 25346.6312 32691.4668 183181.7291 43856.15542 28733.77356 10424.76694 17660.01657 21856.43399 6134.544359 158565.6578 11628.92522 11693.37516 12072.74004 L-TYROSINE 1853340.311 2038299.594 1880896.59 1767757.406 690053.1937 1089312.99 1577025.532 2060445.328 1019643.113 1082837.52 2314809.76 2408348.549 2015616.207 1274818.304 2516288.759 2396777.426 ADENOSINE 5'-MONOPHOSPHATE .006770042 .009717114 .022453876 .010257355 .007842336 .015638742 .012829213 .015617282 .00833924 .007443757 .00612996 .005996644 .040161748 .008225998 .011075174 .013638223 URIDINE 5'-TRIPHOSPHATE 101186.0145 88157.01008 70642.74884 119641.3826 115034.3811 89663.13256 130737.102 115616.9753 116763.3033 89740.19818 133590.7277 97442.95809 20086.68449 138954.2357 121182.0533 201849.0057 L-METHIONINE 533197.7769 616437.7285 672988.2338 591239.899 250802.8355 362985.6244 380297.6367 527068.1216 228285.6114 242375.2042 500959.5656 509987.9994 701234.3653 414226.0696 939005.3589 861360.8748 L-PHENYLALANINE 2698465.05 2853867.67 2867812.95 2474423.633 1119016.226 1803449.533 1888128.148 2490849.191 1502457.073 1482576.063 2678036.524 2696167.321 3267383.342 1922731.457 4044036.06 3710170.053 DL-SERINE 1850361.881 1689308.852 1134630.862 1414697.299 664311.5329 815923.9105 1221842.308 1437393.757 872656.3663 960588.9086 1178242.486 1398385.72 752281.4357 733596.1517 1283525.73 1067511.335 L-ASPARAGINE 2843235.634 2829886.618 2736304.56 3035960.973 2677020.857 3215210.329 2039168.874 2726464.662 2939890.741 2925327.961 2478503.663 2879758.249 3099306.429 2440394.433 3815907.027 3418779.548 L-HISTIDINE 10410887.16 12672428.08 6939867.04 6985533.44 7466958.893 8767270.615 11476715.21 15778041.76 11135663.71 10642590.72 9400824.506 9470430.497 9310372.476 5787083.294 14007932.31 13091733.75 L-VALINE 41657684.17 38020976.63 40730481.36 39615315.68 43784665.19 41631854.56 38810077.16 37150410.38 39731925.39 41872529.7 42198568.33 41264391.9 45387530.28 44761341.2 41285921.93 38597572.73 L-THREONINE 1167693.18 1190221.157 1060191.317 978841.9613 1364648.818 1376614.235 1038452.075 1229521.15 1280577.441 1250970.696 1014919.693 1037024.328 1204340.641 857011.2777 1548785.882 1424731.658 L-TRYPTOPHAN 356720.4704 344059.3827 337645.1322 535887.9656 85401.0288 217257.2261 387311.7546 467099.644 203812.4615 237952.1095 533735.8625 319106.3576 330625.1406 274742.623 329160.4917 375243.4754 L-ARGININE 584377.156 792467.2395 578959.5007 485173.8498 567126.4535 584019.1365 1081749.584 910137.0229 436088.9295 351552.7177 406027.6317 360974.1659 944051.9802 604221.8363 705808.0603 654742.529 OXIGLUTATIONE 4138346.162 3204720.142 3559669.824 2642279.55 5592687.126 4475590.797 3245581.99 3624158.584 4395773.859 3471146.185 4148948.409 5799268.86 3589573.42 3395523.407 7450412.21 6238587.459 D-PANTOTHENIC ACID 8785806.302 11681350.88 8906268.427 7827044.635 6607369.423 4787381.173 7215676.067 6322612.55 5978803.858 6752513.003 9571010.184 11728004.13 7596954.813 9454446.556 9701834.707 11949868.88 5'-GUANYLIC ACID 9623.686858 3985.32443 99509.21205 23532.47436 16510.76344 150894.7629 18960.79508 38160.84895 1494.434176 1552.668294 17287.94443 3167.710351 290239.5708 6175.924698 3848.995318 6388.253433 O-PHOSPHO-L-SERINE 1062461.177 1087141.503 961934.0513 278874.4649 382714.737 639970.2711 516599.5392 681200.803 485162.4984 346133.3747 662608.4066 586439.527 1184064.443 274195.6982 1495407.997 1156663.017 GLYCERATE 3-PHOSPHATE 1.849566003 1.424811546 .512046675 .606554663 .724307902 .341281053 .525315952 .866275454 .58941218 .731903207 1.592912412 1.290033333 .249406339 .749362426 1.874208785 2.175277715 3-GLYCEROPHOSPHATE 4620516.754 2840061.026 6505759.93 4581195.623 2626784.484 2917572.12 3805547.844 5278574.892 2674296.778 2961404.276 7943918.084 4419097.013 3856094 2041493.677 6098874.151 6669943.259 RIBOSE PHOSPHATE .172536194 .152353992 .200054901 .150771251 .097546661 .200870874 .116652625 .203337117 .073111602 .095920726 .162116805 .100856198 .406365077 .068877287 .131898038 .107317074 HYPOXANTHINE 1056913.83 758079.1431 1005473.061 662418.2478 545891.8551 593249.9182 967969.5263 612830.8676 874632.8272 656064.8912 716392.0649 596033.8675 928831.6388 916181.278 1004974.456 1098469.086 INOSINIC ACID 3346477.47 2432549.712 50600899.94 29619751.77 10263337.35 61445062.98 25417590.33 41214779 6248063.692 10752852.68 10013652.68 1785258.259 63103821.49 4682916.744 3768481.574 5495679.695 GUANOSINE DIPHOSPHATE 18717.13373 15274.02918 28135.49414 24976.93532 37307.44922 67885.06227 26394.03973 27701.41423 17352.51558 22822.11152 34670.46853 15717.5614 71899.6276 16365.76904 16428.65334 18300.68188 6-PHOSPHOGLUCONIC ACID .019584558 .016002341 .008921812 .010236046 .010326799 .009985939 .010706581 .01540841 .011336271 .01285533 .021928284 .015842749 .00735747 .010816324 .016563475 .015062229 DL-HOMOCYSTEIC ACID 1944793.173 957467.833 397874.0658 596186.8843 863240.7404 1277337.127 1096577.856 640054.7672 677422.9239 719661.5831 1510296.139 1820265.705 796604.4222 858009.8782 1192449.693 896584.5366 ACETOACETYL-COA .008904697 .008970614 .009052976 .00901687 .00903461 .009480267 .009234711 .00938678 .009104327 .00909944 .009018288 .008885126 .009439027 0 .00907401 .008924986 PHOSPHOCREATINE 4127508.005 2019642.816 413339.2199 891616.0142 2285764.475 532873.5684 1135812.341 580741.0147 3712822.125 1822857.068 3835277.555 6689342.354 173625.3942 2530085.791 3934702.093 3452745.631 L-CITRULLINE 424603.5098 529368.3067 677575.324 630181.0947 1176871.833 1019004.945 258646.2139 362451.3971 1498546.958 1392687.017 349286.6877 441570.3176 936405.9975 576936.294 599183.9079 658466.9619 PALMITIC ACID 25114600.95 12144238.15 17649952.34 40972418.59 20320833.94 25190559.06 20710398.09 13219624.99 66830591.99 20585681.06 22257482.35 18108542.52 17191269.03 18764873.83 16316606.8 18082004.35 PHENYLPYRUVIC ACID 54886.19773 71026.37766 57816.04152 52615.57539 22329.21699 34148.60616 50795.1384 64081.03606 55915.36041 31519.11679 69632.89351 76708.97685 59725.78469 42366.84424 77829.95185 75952.76593 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name moverz_quant ri ri_type pubchem_id inchi_key kegg_id other_id other_id_type PHOSPHOENOLPYRUVATE 1005 GLUCONIC ACID 10690 TAURINE 1123 URIC ACID 1175 D-ERYTHROSE 4-PHOSPHATE 122357 GLUTATHIONE 124886 L-PROLINE 145742 BETA-NAD+ 15938971 COENZYME II 15938972 SEDOHEPTULOSE 7-PHOSPHATE 165007 UDP-GLUCURONIC ACID 17473 ACETYLPHOSPHATE 186 D-FRUCTOSE, 1,6-BIS(DIHYDROGEN PHOSPHATE) 21125049 NADP-REDUCED 22833512 CITRIC ACID 311 L-GLUTAMIC ACID 33032 NADH 439153 N-ACETYL-D-GLUCOSAMINE 1-PHOSPHATE 440272 OLEIC ACID 445639 UDP-N-ACETYLGLUCOSAMINE 445675 FAD 46906035 MALIC ACID 525 STEARIC ACID 5281 UDPGLUCOSE 53477679 D-GLUCOSE 5793 CREATINE 586 L-ALANINE 5950 ADENOSINE TRIPHOSPHATE 5957 ROBISON ESTER 5958 L-ASPARTIC ACID 5960 L-GLUTAMINE 5961 L-LYSINE 5962 SUCROSE 5988 INOSINE 6021 ADENOSINE 5'-DIPHOSPHATE 6022 URIDYLIC ACID 6030 URIDINE 5'-DIPHOSPHATE 6031 L-TYROSINE 6057 ADENOSINE 5'-MONOPHOSPHATE 6083 URIDINE 5'-TRIPHOSPHATE 6133 L-METHIONINE 6137 L-PHENYLALANINE 6140 DL-SERINE 617 L-ASPARAGINE 6267 L-HISTIDINE 6274 L-VALINE 6287 L-THREONINE 6288 L-TRYPTOPHAN 6305 L-ARGININE 6322 OXIGLUTATIONE 65359 D-PANTOTHENIC ACID 6613 5'-GUANYLIC ACID 6804 O-PHOSPHO-L-SERINE 68841 GLYCERATE 3-PHOSPHATE 724 3-GLYCEROPHOSPHATE 754 RIBOSE PHOSPHATE 77982 HYPOXANTHINE 790 INOSINIC ACID 8582 GUANOSINE DIPHOSPHATE 8977 6-PHOSPHOGLUCONIC ACID 91493 DL-HOMOCYSTEIC ACID 92117 ACETOACETYL-COA 92153 PHOSPHOCREATINE 9548602 L-CITRULLINE 9750 PALMITIC ACID 985 PHENYLPYRUVIC ACID 997 METABOLITES_END #END