#METABOLOMICS WORKBENCH efahy_20180114_111150 DATATRACK_ID:1297 STUDY_ID:ST000915 ANALYSIS_ID:AN001485 PROJECT_ID:PR000633 VERSION 1 CREATED_ON January 14, 2018, 11:41 am #PROJECT PR:PROJECT_TITLE Biomarkers of NAFLD progression: a lipidomics approach to an epidemic PR:PROJECT_TYPE Lipidomics Study PR:PROJECT_SUMMARY The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, PR:PROJECT_SUMMARY nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely PR:PROJECT_SUMMARY diagnosis of these different stages, particularly NASH, is important for both PR:PROJECT_SUMMARY potential reversibility and limitation of complications. Liver biopsy remains PR:PROJECT_SUMMARY the clinical standard for definitive diagnosis. Diagnostic tools minimizing the PR:PROJECT_SUMMARY need for invasive procedures or that add information to histologic data are PR:PROJECT_SUMMARY important in novel management strategies for the growing epidemic of NAFLD. We PR:PROJECT_SUMMARY describe an 'omics' approach to detecting a reproducible signature of lipid PR:PROJECT_SUMMARY metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a PR:PROJECT_SUMMARY double-blinded study of patients with different stages of NAFLD that involves PR:PROJECT_SUMMARY profiling liver biopsies, plasma, and urine samples. Using linear discriminant PR:PROJECT_SUMMARY analysis, a panel of 20 plasma metabolites that includes glycerophospholipids, PR:PROJECT_SUMMARY sphingolipids, sterols, and various aqueous small molecular weight components PR:PROJECT_SUMMARY involved in cellular metabolic pathways, can be used to differentiate between PR:PROJECT_SUMMARY NASH and steatosis. This identification of differential biomolecular signatures PR:PROJECT_SUMMARY has the potential to improve clinical diagnosis and facilitate therapeutic PR:PROJECT_SUMMARY intervention of NAFLD. PR:INSTITUTE University of California, San Diego PR:DEPARTMENT Bioengineering PR:LAST_NAME Fahy PR:FIRST_NAME Eoin PR:ADDRESS 9500 Gilman, La Jolla, CA, 92093, USA PR:EMAIL efahy@ucsd.edu PR:PHONE 858-534-4076 PR:FUNDING_SOURCE NIGMS Grant GM U54069338 PR:PUBLICATIONS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/ PR:CONTRIBUTORS LIPID MAPS Consortium #STUDY ST:STUDY_TITLE Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part ST:STUDY_TITLE 1:Liver ST:STUDY_TYPE Lipidomics Study ST:STUDY_SUMMARY The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, ST:STUDY_SUMMARY nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely ST:STUDY_SUMMARY diagnosis of these different stages, particularly NASH, is important for both ST:STUDY_SUMMARY potential reversibility and limitation of complications. Liver biopsy remains ST:STUDY_SUMMARY the clinical standard for definitive diagnosis. Diagnostic tools minimizing the ST:STUDY_SUMMARY need for invasive procedures or that add information to histologic data are ST:STUDY_SUMMARY important in novel management strategies for the growing epidemic of NAFLD. We ST:STUDY_SUMMARY describe an 'omics' approach to detecting a reproducible signature of lipid ST:STUDY_SUMMARY metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a ST:STUDY_SUMMARY double-blinded study of patients with different stages of NAFLD that involves ST:STUDY_SUMMARY profiling liver biopsies, plasma, and urine samples. Using linear discriminant ST:STUDY_SUMMARY analysis, a panel of 20 plasma metabolites that includes glycerophospholipids, ST:STUDY_SUMMARY sphingolipids, sterols, and various aqueous small molecular weight components ST:STUDY_SUMMARY involved in cellular metabolic pathways, can be used to differentiate between ST:STUDY_SUMMARY NASH and steatosis. This identification of differential biomolecular signatures ST:STUDY_SUMMARY has the potential to improve clinical diagnosis and facilitate therapeutic ST:STUDY_SUMMARY intervention of NAFLD. ST:INSTITUTE University of California, San Diego ST:DEPARTMENT Bioengineering ST:LAST_NAME Fahy ST:FIRST_NAME Eoin ST:ADDRESS 9500 Gilman, La Jolla, CA, 92093, USA ST:EMAIL efahy@ucsd.edu ST:PHONE 858-534-4076 ST:PUBLICATIONS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/ #SUBJECT SU:SUBJECT_TYPE Human clinical study SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:AGE_OR_AGE_RANGE 23-83 SU:GENDER Male and Female SU:HUMAN_ETHNICITY Black/White #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - NASH005 Diagnosis:Cirrhosis GENDER=M; BMI=31; ETHNICITY=White; AGE=45; AST=55; ALT=20; ALKP=171; TBIL=8.2; GLUCOSE=- SUBJECT_SAMPLE_FACTORS - NASH007 Diagnosis:Cirrhosis GENDER=F; BMI=40.3; ETHNICITY=White; AGE=64; AST=39; ALT=20; ALKP=102; TBIL=3; GLUCOSE=92 SUBJECT_SAMPLE_FACTORS - NASH009 Diagnosis:Cirrhosis GENDER=M; BMI=40; ETHNICITY=White; AGE=49; AST=162; ALT=66; ALKP=123; TBIL=10.5; GLUCOSE=119 SUBJECT_SAMPLE_FACTORS - NASH013 Diagnosis:Cirrhosis GENDER=M; BMI=35; ETHNICITY=White; AGE=59; AST=44; ALT=32; ALKP=95; TBIL=2.9; GLUCOSE=100 SUBJECT_SAMPLE_FACTORS - NASH016 Diagnosis:Cirrhosis GENDER=M; BMI=26; ETHNICITY=Asian; AGE=66; AST=223; ALT=100; ALKP=149; TBIL=5.2; GLUCOSE=117 SUBJECT_SAMPLE_FACTORS - NASH022 Diagnosis:Cirrhosis GENDER=M; BMI=27; ETHNICITY=White; AGE=63; AST=55; ALT=34; ALKP=91; TBIL=6.5; GLUCOSE=220 SUBJECT_SAMPLE_FACTORS - NASH026 Diagnosis:Cirrhosis GENDER=M; BMI=26.5; ETHNICITY=White; AGE=57; AST=18; ALT=38; ALKP=37; TBIL=4.2; GLUCOSE=122 SUBJECT_SAMPLE_FACTORS - NASH027 Diagnosis:Cirrhosis GENDER=M; BMI=31; ETHNICITY=-; AGE=58; AST=30; ALT=36; ALKP=105; TBIL=3.4; GLUCOSE=131 SUBJECT_SAMPLE_FACTORS - NASH028 Diagnosis:Cirrhosis GENDER=F; BMI=31; ETHNICITY=White; AGE=48; AST=46; ALT=47; ALKP=192; TBIL=2.4; GLUCOSE=173 SUBJECT_SAMPLE_FACTORS - NASH029 Diagnosis:Cirrhosis GENDER=F; BMI=21.5; ETHNICITY=White; AGE=49; AST=92; ALT=54; ALKP=277; TBIL=41.7; GLUCOSE=113 SUBJECT_SAMPLE_FACTORS - NASH040 Diagnosis:Cirrhosis GENDER=F; BMI=44; ETHNICITY=White; AGE=63; AST=36; ALT=26; ALKP=62; TBIL=1.7; GLUCOSE=65 SUBJECT_SAMPLE_FACTORS - NASH047 Diagnosis:Cirrhosis GENDER=M; BMI=-; ETHNICITY=White; AGE=60; AST=51; ALT=24; ALKP=57; TBIL=11.3; GLUCOSE=241 SUBJECT_SAMPLE_FACTORS - NASH048 Diagnosis:Cirrhosis GENDER=M; BMI=26; ETHNICITY=White; AGE=66; AST=44; ALT=23; ALKP=100; TBIL=4.5; GLUCOSE=79 SUBJECT_SAMPLE_FACTORS - NASH049 Diagnosis:Cirrhosis GENDER=M; BMI=35; ETHNICITY=White; AGE=71; AST=42; ALT=21; ALKP=82; TBIL=3.8; GLUCOSE=145 SUBJECT_SAMPLE_FACTORS - NASH052 Diagnosis:Cirrhosis GENDER=M; BMI=-; ETHNICITY=-; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=- SUBJECT_SAMPLE_FACTORS - NASH055 Diagnosis:Cirrhosis GENDER=M; BMI=36.8; ETHNICITY=White; AGE=67; AST=35; ALT=24; ALKP=91; TBIL=0.9; GLUCOSE=135 SUBJECT_SAMPLE_FACTORS - NASH064 Diagnosis:Cirrhosis GENDER=F; BMI=27.9; ETHNICITY=White; AGE=67; AST=67; ALT=31; ALKP=113; TBIL=5.5; GLUCOSE=82 SUBJECT_SAMPLE_FACTORS - NASH065 Diagnosis:Cirrhosis GENDER=M; BMI=41.9; ETHNICITY=White; AGE=36; AST=32; ALT=17; ALKP=44; TBIL=0.2; GLUCOSE=91 SUBJECT_SAMPLE_FACTORS - NASH068 Diagnosis:Cirrhosis GENDER=M; BMI=23; ETHNICITY=White; AGE=55; AST=46; ALT=21; ALKP=67; TBIL=1.4; GLUCOSE=96 SUBJECT_SAMPLE_FACTORS - NASH069 Diagnosis:Cirrhosis GENDER=M; BMI=29.9; ETHNICITY=White; AGE=56; AST=74; ALT=57; ALKP=258; TBIL=3.1; GLUCOSE=84 SUBJECT_SAMPLE_FACTORS - NASH010 Diagnosis:NASH GENDER=F; BMI=43.3; ETHNICITY=White; AGE=46; AST=33; ALT=35; ALKP=71; TBIL=0.4; GLUCOSE=175 SUBJECT_SAMPLE_FACTORS - NASH012 Diagnosis:NASH GENDER=F; BMI=49; ETHNICITY=White; AGE=38; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=89 SUBJECT_SAMPLE_FACTORS - NASH015 Diagnosis:NASH GENDER=M; BMI=44; ETHNICITY=White; AGE=58; AST=27; ALT=39; ALKP=41; TBIL=0.2; GLUCOSE=125 SUBJECT_SAMPLE_FACTORS - NASH018 Diagnosis:NASH GENDER=F; BMI=51; ETHNICITY=Black; AGE=44; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=96 SUBJECT_SAMPLE_FACTORS - NASH019 Diagnosis:NASH GENDER=M; BMI=34; ETHNICITY=White; AGE=73; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=107 SUBJECT_SAMPLE_FACTORS - NASH021 Diagnosis:NASH GENDER=M; BMI=28; ETHNICITY=White; AGE=59; AST=30; ALT=39; ALKP=63; TBIL=0.9; GLUCOSE=185 SUBJECT_SAMPLE_FACTORS - NASH030 Diagnosis:NASH GENDER=F; BMI=41.6; ETHNICITY=White; AGE=28; AST=24; ALT=24; ALKP=77; TBIL=0.1; GLUCOSE=89 SUBJECT_SAMPLE_FACTORS - NASH031 Diagnosis:NASH GENDER=F; BMI=41.5; ETHNICITY=White; AGE=46; AST=17; ALT=23; ALKP=94; TBIL=0.2; GLUCOSE=135 SUBJECT_SAMPLE_FACTORS - NASH035 Diagnosis:NASH GENDER=M; BMI=74.7; ETHNICITY=White; AGE=45; AST=23; ALT=30; ALKP=72; TBIL=0.3; GLUCOSE=84 SUBJECT_SAMPLE_FACTORS - NASH037 Diagnosis:NASH GENDER=M; BMI=44; ETHNICITY=White; AGE=53; AST=52; ALT=83; ALKP=98; TBIL=0.3; GLUCOSE=165 SUBJECT_SAMPLE_FACTORS - NASH038 Diagnosis:NASH GENDER=M; BMI=45; ETHNICITY=White; AGE=65; AST=36; ALT=37; ALKP=67; TBIL=0.3; GLUCOSE=97 SUBJECT_SAMPLE_FACTORS - NASH039 Diagnosis:NASH GENDER=M; BMI=48; ETHNICITY=White; AGE=35; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=- SUBJECT_SAMPLE_FACTORS - NASH044 Diagnosis:NASH GENDER=M; BMI=61; ETHNICITY=Black; AGE=41; AST=22; ALT=24; ALKP=57; TBIL=0.6; GLUCOSE=89 SUBJECT_SAMPLE_FACTORS - NASH057 Diagnosis:NASH GENDER=F; BMI=47.3; ETHNICITY=White; AGE=53; AST=25; ALT=18; ALKP=71; TBIL=0.6; GLUCOSE=99 SUBJECT_SAMPLE_FACTORS - NASH072 Diagnosis:NASH GENDER=M; BMI=77.3; ETHNICITY=White; AGE=50; AST=29; ALT=12; ALKP=85; TBIL=0.8; GLUCOSE=207 SUBJECT_SAMPLE_FACTORS - NASH074 Diagnosis:NASH GENDER=F; BMI=31; ETHNICITY=White; AGE=52; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=169 SUBJECT_SAMPLE_FACTORS - NASH084 Diagnosis:NASH GENDER=F; BMI=63; ETHNICITY=White; AGE=48; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=120 SUBJECT_SAMPLE_FACTORS - NASH087 Diagnosis:NASH GENDER=F; BMI=52; ETHNICITY=Black; AGE=58; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=175 SUBJECT_SAMPLE_FACTORS - NASH088 Diagnosis:NASH GENDER=F; BMI=40; ETHNICITY=Black; AGE=27; AST=15; ALT=19; ALKP=134; TBIL=0.4; GLUCOSE=133 SUBJECT_SAMPLE_FACTORS - NASH090 Diagnosis:NASH GENDER=F; BMI=35; ETHNICITY=White; AGE=32; AST=15; ALT=20; ALKP=69; TBIL=-; GLUCOSE=110 SUBJECT_SAMPLE_FACTORS - NASH003 Diagnosis:Normal GENDER=F; BMI=47.3; ETHNICITY=White; AGE=46; AST=36; ALT=54; ALKP=76; TBIL=-; GLUCOSE=90 SUBJECT_SAMPLE_FACTORS - NASH004 Diagnosis:Normal GENDER=M; BMI=-; ETHNICITY=White; AGE=23; AST=106; ALT=95; ALKP=-; TBIL=0.7; GLUCOSE=97 SUBJECT_SAMPLE_FACTORS - NASH006 Diagnosis:Normal GENDER=F; BMI=-; ETHNICITY=White; AGE=40; AST=68; ALT=72; ALKP=74; TBIL=0.5; GLUCOSE=93 SUBJECT_SAMPLE_FACTORS - NASH011 Diagnosis:Normal GENDER=M; BMI=29.1; ETHNICITY=White; AGE=54; AST=40; ALT=22; ALKP=42; TBIL=0.9; GLUCOSE=101 SUBJECT_SAMPLE_FACTORS - NASH014 Diagnosis:Normal GENDER=F; BMI=36; ETHNICITY=Black; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=139 SUBJECT_SAMPLE_FACTORS - NASH017 Diagnosis:Normal GENDER=M; BMI=45; ETHNICITY=White; AGE=59; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=101 SUBJECT_SAMPLE_FACTORS - NASH020 Diagnosis:Normal GENDER=M; BMI=29; ETHNICITY=White; AGE=33; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=91 SUBJECT_SAMPLE_FACTORS - NASH024 Diagnosis:Normal GENDER=F; BMI=35; ETHNICITY=Black; AGE=43; AST=20; ALT=13; ALKP=71; TBIL=0.9; GLUCOSE=95 SUBJECT_SAMPLE_FACTORS - NASH034 Diagnosis:Normal GENDER=F; BMI=51.5; ETHNICITY=White; AGE=49; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=172 SUBJECT_SAMPLE_FACTORS - NASH036 Diagnosis:Normal GENDER=F; BMI=39; ETHNICITY=Black; AGE=45; AST=21; ALT=23; ALKP=111; TBIL=0.2; GLUCOSE=99 SUBJECT_SAMPLE_FACTORS - NASH041 Diagnosis:Normal GENDER=F; BMI=63; ETHNICITY=Black; AGE=27; AST=21; ALT=19; ALKP=86; TBIL=0.3; GLUCOSE=106 SUBJECT_SAMPLE_FACTORS - NASH042 Diagnosis:Normal GENDER=F; BMI=42; ETHNICITY=White; AGE=58; AST=18; ALT=16; ALKP=98; TBIL=0.4; GLUCOSE=105 SUBJECT_SAMPLE_FACTORS - NASH043 Diagnosis:Normal GENDER=F; BMI=52; ETHNICITY=White; AGE=39; AST=13; ALT=12; ALKP=76; TBIL=0.3; GLUCOSE=104 SUBJECT_SAMPLE_FACTORS - NASH045 Diagnosis:Normal GENDER=F; BMI=48; ETHNICITY=Black; AGE=43; AST=13; ALT=15; ALKP=90; TBIL=0.3; GLUCOSE=104 SUBJECT_SAMPLE_FACTORS - NASH046 Diagnosis:Normal GENDER=F; BMI=40; ETHNICITY=White; AGE=36; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=104 SUBJECT_SAMPLE_FACTORS - NASH050 Diagnosis:Normal GENDER=F; BMI=52.5; ETHNICITY=Black; AGE=38; AST=15; ALT=12; ALKP=75; TBIL=0.1; GLUCOSE=96 SUBJECT_SAMPLE_FACTORS - NASH051 Diagnosis:Normal GENDER=F; BMI=50.6; ETHNICITY=White; AGE=29; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=99 SUBJECT_SAMPLE_FACTORS - NASH053 Diagnosis:Normal GENDER=F; BMI=25.1; ETHNICITY=White; AGE=56; AST=26; ALT=14; ALKP=180; TBIL=0.8; GLUCOSE=140 SUBJECT_SAMPLE_FACTORS - NASH054 Diagnosis:Normal GENDER=F; BMI=30.8; ETHNICITY=White; AGE=83; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=90 SUBJECT_SAMPLE_FACTORS - NASH060 Diagnosis:Normal GENDER=F; BMI=39.7; ETHNICITY=Black; AGE=36; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=115 SUBJECT_SAMPLE_FACTORS - NASH066 Diagnosis:Normal GENDER=F; BMI=40.3; ETHNICITY=Black; AGE=52; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=95 SUBJECT_SAMPLE_FACTORS - NASH067 Diagnosis:Normal GENDER=F; BMI=39.2; ETHNICITY=Black; AGE=33; AST=17; ALT=14; ALKP=73; TBIL=0.2; GLUCOSE=87 SUBJECT_SAMPLE_FACTORS - NASH070 Diagnosis:Normal GENDER=F; BMI=25.7; ETHNICITY=White; AGE=53; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=- SUBJECT_SAMPLE_FACTORS - NASH077 Diagnosis:Normal GENDER=M; BMI=33; ETHNICITY=White; AGE=67; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=193 SUBJECT_SAMPLE_FACTORS - NASH078 Diagnosis:Normal GENDER=F; BMI=45; ETHNICITY=Black; AGE=40; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=101 SUBJECT_SAMPLE_FACTORS - NASH080 Diagnosis:Normal GENDER=F; BMI=50; ETHNICITY=White; AGE=57; AST=26; ALT=28; ALKP=54; TBIL=0.3; GLUCOSE=155 SUBJECT_SAMPLE_FACTORS - NASH082 Diagnosis:Normal GENDER=M; BMI=34; ETHNICITY=White; AGE=73; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=- SUBJECT_SAMPLE_FACTORS - NASH085 Diagnosis:Normal GENDER=F; BMI=32; ETHNICITY=White; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=- SUBJECT_SAMPLE_FACTORS - NASH086 Diagnosis:Normal GENDER=F; BMI=38; ETHNICITY=White; AGE=35; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=99 SUBJECT_SAMPLE_FACTORS - NASH089 Diagnosis:Normal GENDER=F; BMI=52; ETHNICITY=White; AGE=49; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=- SUBJECT_SAMPLE_FACTORS - NASH091 Diagnosis:Normal GENDER=F; BMI=29; ETHNICITY=White; AGE=68; AST=14; ALT=18; ALKP=66; TBIL=0.4; GLUCOSE=107 SUBJECT_SAMPLE_FACTORS - NASH001 Diagnosis:Steatosis GENDER=M; BMI=52.3; ETHNICITY=Black; AGE=37; AST=16; ALT=19; ALKP=58; TBIL=0.4; GLUCOSE=236 SUBJECT_SAMPLE_FACTORS - NASH002 Diagnosis:Steatosis GENDER=F; BMI=34.9; ETHNICITY=White; AGE=57; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=91 SUBJECT_SAMPLE_FACTORS - NASH023 Diagnosis:Steatosis GENDER=M; BMI=34; ETHNICITY=White; AGE=56; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=97 SUBJECT_SAMPLE_FACTORS - NASH032 Diagnosis:Steatosis GENDER=F; BMI=45; ETHNICITY=White; AGE=58; AST=27; ALT=20; ALKP=83; TBIL=0.9; GLUCOSE=89 SUBJECT_SAMPLE_FACTORS - NASH033 Diagnosis:Steatosis GENDER=F; BMI=40; ETHNICITY=White; AGE=58; AST=38; ALT=29; ALKP=102; TBIL=0.5; GLUCOSE=109 SUBJECT_SAMPLE_FACTORS - NASH056 Diagnosis:Steatosis GENDER=F; BMI=45.1; ETHNICITY=White; AGE=51; AST=38; ALT=28; ALKP=45; TBIL=0.5; GLUCOSE=99 SUBJECT_SAMPLE_FACTORS - NASH058 Diagnosis:Steatosis GENDER=M; BMI=42.7; ETHNICITY=Black; AGE=53; AST=28; ALT=34; ALKP=72; TBIL=0.6; GLUCOSE=174 SUBJECT_SAMPLE_FACTORS - NASH059 Diagnosis:Steatosis GENDER=F; BMI=49.8; ETHNICITY=White; AGE=45; AST=16; ALT=16; ALKP=84; TBIL=0.3; GLUCOSE=92 SUBJECT_SAMPLE_FACTORS - NASH061 Diagnosis:Steatosis GENDER=F; BMI=56.7; ETHNICITY=White; AGE=29; AST=64; ALT=50; ALKP=68; TBIL=0.8; GLUCOSE=91 SUBJECT_SAMPLE_FACTORS - NASH062 Diagnosis:Steatosis GENDER=F; BMI=56.6; ETHNICITY=White; AGE=51; AST=15; ALT=16; ALKP=58; TBIL=0.5; GLUCOSE=90 SUBJECT_SAMPLE_FACTORS - NASH071 Diagnosis:Steatosis GENDER=F; BMI=40; ETHNICITY=White; AGE=33; AST=15; ALT=12; ALKP=59; TBIL=0.4; GLUCOSE=85 SUBJECT_SAMPLE_FACTORS - NASH073 Diagnosis:Steatosis GENDER=F; BMI=80.2; ETHNICITY=Black; AGE=34; AST=11; ALT=11; ALKP=90; TBIL=0.4; GLUCOSE=163 SUBJECT_SAMPLE_FACTORS - NASH075 Diagnosis:Steatosis GENDER=M; BMI=33; ETHNICITY=White; AGE=67; AST=22; ALT=34; ALKP=96; TBIL=0.5; GLUCOSE=191 SUBJECT_SAMPLE_FACTORS - NASH076 Diagnosis:Steatosis GENDER=F; BMI=50; ETHNICITY=White; AGE=51; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=92 SUBJECT_SAMPLE_FACTORS - NASH079 Diagnosis:Steatosis GENDER=F; BMI=43; ETHNICITY=White; AGE=37; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=85 SUBJECT_SAMPLE_FACTORS - NASH081 Diagnosis:Steatosis GENDER=F; BMI=46; ETHNICITY=White; AGE=65; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=119 SUBJECT_SAMPLE_FACTORS - NASH083 Diagnosis:Steatosis GENDER=M; BMI=39; ETHNICITY=White; AGE=41; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=106 #COLLECTION CO:COLLECTION_SUMMARY Human samples were collected according to a protocol approved by Vanderbilt CO:COLLECTION_SUMMARY University Medical Center's Internal Review Board (#120829) and under informed CO:COLLECTION_SUMMARY written patients' consent prior to inclusion in this study. Sample sizes were CO:COLLECTION_SUMMARY selected to minimize the invasive procedures. Plasma samples were obtained from CO:COLLECTION_SUMMARY patients' blood collected during standard of care surgical procedures. Urine CO:COLLECTION_SUMMARY samples were collected from patients' Foley catheters placed for standard of CO:COLLECTION_SUMMARY care procedure. Liver samples were obtained from the excess tissue collected as CO:COLLECTION_SUMMARY part of the standard of care liver biopsies performed at the time of surgery CO:COLLECTION_SUMMARY that would otherwise be discarded. Subsequently, studies at University of CO:COLLECTION_SUMMARY California, San Diego were conducted under further auspices of University of CO:COLLECTION_SUMMARY California, San Diego Internal Review Board #121220. CO:SAMPLE_TYPE Liver #TREATMENT TR:TREATMENT_SUMMARY - #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Liver sample extraction. Approximately 10 mg of frozen liver was homogenized in SP:SAMPLEPREP_SUMMARY 500 µl of cold (-20°C) 70% CH3OH using a tight-fit glass homogenizer SP:SAMPLEPREP_SUMMARY (Kimble/Kontes Glass Co., Vineland, NJ) for about 1 min on ice in the presence SP:SAMPLEPREP_SUMMARY of 4 µl of internal standard mix. The suspension was vortexed for 10 s and left SP:SAMPLEPREP_SUMMARY in an ice bath for 30 min. After mixing by vortex at 4°C for 1 min and SP:SAMPLEPREP_SUMMARY centrifugation (4°C, 18,000 g, 10 min), the supernatant was collected and the SP:SAMPLEPREP_SUMMARY solvent was evaporated. The residue was dissolved in 200 µl of resuspension SP:SAMPLEPREP_SUMMARY solvent, vortexed to mix (1 min at 4°C), and centrifuged (4°C, 18,000 g, 10 SP:SAMPLEPREP_SUMMARY min) to remove any insoluble material. GPLs: GPLs from liver samples were SP:SAMPLEPREP_SUMMARY extracted and analyzed by MS essentially as described in (20, 21). Extraction SP:SAMPLEPREP_SUMMARY and analysis of plasma samples was according to previously published procedures SP:SAMPLEPREP_SUMMARY (22). Cardiolipin, coenzyme Q, and dolichol: Lipid extractions were performed SP:SAMPLEPREP_SUMMARY based on the Bligh and Dyer method with minor modifications (23-25). FAs and SP:SAMPLEPREP_SUMMARY eicosanoids: FFAs were extracted essentially as previously described after SP:SAMPLEPREP_SUMMARY supplementation with deuterated internal standards (Cayman Chemicals) (26, 27). SP:SAMPLEPREP_SUMMARY Eicosanoids were isolated via solid phase extraction, utilizing 25 deuterated SP:SAMPLEPREP_SUMMARY internal standards (28, 29). Sterols and oxysterols: Sterols and oxysterols were SP:SAMPLEPREP_SUMMARY extracted using previously described methods (30). Neutral lipids: Cholesteryl SP:SAMPLEPREP_SUMMARY esters (CEs), TAGs, and DAGs were extracted from weighed liver tissue (0.5-1 mg) SP:SAMPLEPREP_SUMMARY suspended in 0.5 ml PBS that had been homogenized by sonication. Extractions of SP:SAMPLEPREP_SUMMARY plasma (0.05 ml diluted to 0.1 ml with PBS), urine (1 ml), and tissue sonicates SP:SAMPLEPREP_SUMMARY were carried out using 1 ml hexane:methyl t-butyl ether (1:1, v/v), essentially SP:SAMPLEPREP_SUMMARY as previously described (31). Sphingolipids: Sphingolipids from liver, plasma, SP:SAMPLEPREP_SUMMARY and urine were extracted following previously published procedures (32, 33), SP:SAMPLEPREP_SUMMARY with the exception that methylene chloride was substituted for chloroform for SP:SAMPLEPREP_SUMMARY the single-phase extraction of sphingoid bases 20. Ivanova P. T., Milne S. B., SP:SAMPLEPREP_SUMMARY Byrne M. O., Xiang Y., Brown H. A. 2007. Glycerophospholipid identification and SP:SAMPLEPREP_SUMMARY quantitation by electrospray ionization mass spectrometry. Methods Enzymol. 432: SP:SAMPLEPREP_SUMMARY 21-57. 21. Myers D. S., Ivanova P. T., Milne S. B., Brown H. A. 2011. SP:SAMPLEPREP_SUMMARY Quantitative analysis of glycerophospholipids by LC-MS: acquisition, data SP:SAMPLEPREP_SUMMARY handling, and interpretation. Biochim. Biophys. Acta. 1811: 748-757. 22. SP:SAMPLEPREP_SUMMARY Quehenberger O., Armando A. M., Brown H. A., Milne S. B., Myers D. S., Merrill SP:SAMPLEPREP_SUMMARY A. H., Jr, Bandyopadhyay S., Jones K. N., Kelly S., Shaner R. L., et al. 2010. SP:SAMPLEPREP_SUMMARY Lipidomics reveals a remarkable diversity of lipids in human plasma. J. Lipid SP:SAMPLEPREP_SUMMARY Res. 51: 3299-3305. 23. Guan Z., Li S., Smith D., Shaw W., Raetz C. 2007. SP:SAMPLEPREP_SUMMARY Identification of N-acylphosphatidylserine molecules in eukaryotic cells. SP:SAMPLEPREP_SUMMARY Biochemistry. 46: 14500-14513. 24. Tan B. K., Bogdanov M., Zhao J., Dowhan W., SP:SAMPLEPREP_SUMMARY Raetz C. R., Guan Z. 2012. Discovery of cardiolipin synthase utilizing SP:SAMPLEPREP_SUMMARY phosphatidylethanolamine and phosphatidylglycerol as substrates. Proc. Natl. SP:SAMPLEPREP_SUMMARY Acad. Sci. USA. 109: 16504-16509. 25. Wen R., Lam B., Guan Z. 2013. Aberrant SP:SAMPLEPREP_SUMMARY dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired SP:SAMPLEPREP_SUMMARY dolichol biosynthesis. J. Lipid Res. 54: 3516-3522. 26. Quehenberger O., SP:SAMPLEPREP_SUMMARY Armando A., Dumlao D., Stephens D. L., Dennis E. A. 2008. Lipidomics analysis of SP:SAMPLEPREP_SUMMARY essential fatty acids in macrophages. Prostaglandins Leukot. Essent. Fatty SP:SAMPLEPREP_SUMMARY Acids. 79: 123-129. 27. Quehenberger O., Armando A. M., Dennis E. A. 2011. High SP:SAMPLEPREP_SUMMARY sensitivity quantitative lipidomics analysis of fatty acids in biological SP:SAMPLEPREP_SUMMARY samples by gas chromatography-mass spectrometry. Biochim. Biophys. Acta. 1811: SP:SAMPLEPREP_SUMMARY 648-656. 28. Deems R., Buczynski M. W., Bowers-Gentry R., Harkewicz R., Dennis SP:SAMPLEPREP_SUMMARY E. A. 2007. Detection and quantitation of eicosanoids via high performance SP:SAMPLEPREP_SUMMARY liquid chromatography-electrospray ionization-mass spectrometry. Methods SP:SAMPLEPREP_SUMMARY Enzymol. 432: 59-82. 29. Dumlao D. S., Buczynski M. W., Norris P. C., Harkewicz SP:SAMPLEPREP_SUMMARY R., Dennis E. A. 2011. High-throughput lipidomic analysis of fatty acid derived SP:SAMPLEPREP_SUMMARY eicosanoids and N-acylethanolamines. Biochim. Biophys. Acta. 1811: 724-736. 30. SP:SAMPLEPREP_SUMMARY McDonald J. G., Smith D. D., Stiles A. R., Russell D. W. 2012. A comprehensive SP:SAMPLEPREP_SUMMARY method for extraction and quantitative analysis of sterols and secosteroids from SP:SAMPLEPREP_SUMMARY human plasma. J. Lipid Res. 53: 1399-1409. 31. Hutchins P. M., Barkley R. M., SP:SAMPLEPREP_SUMMARY Murphy R. C. 2008. Separation of cellular nonpolar neutral lipids by SP:SAMPLEPREP_SUMMARY normal-phase chromatography and analysis by electrospray ionization mass SP:SAMPLEPREP_SUMMARY spectrometry. J. Lipid Res. 49: 804-813. 32. Shaner R. L., Allegood J. C., Park SP:SAMPLEPREP_SUMMARY H., Wang E., Kelly S., Haynes C. A., Sullards M. C., Merrill A. H., Jr 2009. SP:SAMPLEPREP_SUMMARY Quantitative analysis of sphingolipids for lipidomics using triple quadrupole SP:SAMPLEPREP_SUMMARY and quadrupole linear ion trap mass spectrometers. J. Lipid Res. 50: 1692-1707. SP:SAMPLEPREP_SUMMARY 33. Sullards M. C., Liu Y., Chen Y., Merrill A. H., Jr 2011. Analysis of SP:SAMPLEPREP_SUMMARY mammalian sphingolipids by liquid chromatography tandem mass spectrometry SP:SAMPLEPREP_SUMMARY (LC-MS/MS) and tissue imaging mass spectrometry (TIMS). Biochim. Biophys. Acta. SP:SAMPLEPREP_SUMMARY 1811: 838-853. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY FFAs were analyzed by stable isotope dilution GC-MS after derivatization, CH:CHROMATOGRAPHY_SUMMARY essentially as described previously (26, 27). This method quantifies 33 FAs CH:CHROMATOGRAPHY_SUMMARY including all major and minor saturated FAs, monounsaturated FAs, and PUFAs CH:CHROMATOGRAPHY_SUMMARY containing 12 to 26 carbons. Eicosanoids were analyzed by a stable isotope CH:CHROMATOGRAPHY_SUMMARY dilution LC/MS method utilizing 26 deuterated internal standards (28, 29). The CH:CHROMATOGRAPHY_SUMMARY metabolites were quantified after separation by reverse phase chromatography on CH:CHROMATOGRAPHY_SUMMARY a 2.1 × 100 mm BEH Shield column, 1.7 µM (Waters, Milford, MA) employing an CH:CHROMATOGRAPHY_SUMMARY Acquity UPLC system (Waters). Detection and quantification were performed on an CH:CHROMATOGRAPHY_SUMMARY AB SCIEX 6500 QTrap mass spectrometer equipped with an IonDrive Turbo V source CH:CHROMATOGRAPHY_SUMMARY (AB SCIEX, Framingham, MA), operated in negative ionization mode via MRM, using CH:CHROMATOGRAPHY_SUMMARY standard curves generated from 145 authentic quantification standards (34). The CH:CHROMATOGRAPHY_SUMMARY method analyzes an additional 13 metabolites based on authentic primary CH:CHROMATOGRAPHY_SUMMARY standards, but which cannot be quantified due to the lack of appropriate CH:CHROMATOGRAPHY_SUMMARY internal standards. Data analysis was performed using MultiQuant 2.1 software CH:CHROMATOGRAPHY_SUMMARY (AB SCIEX). 26. Quehenberger O., Armando A., Dumlao D., Stephens D. L., Dennis CH:CHROMATOGRAPHY_SUMMARY E. A. 2008. Lipidomics analysis of essential fatty acids in macrophages. CH:CHROMATOGRAPHY_SUMMARY Prostaglandins Leukot. Essent. Fatty Acids. 79: 123-129. 27. Quehenberger O., CH:CHROMATOGRAPHY_SUMMARY Armando A. M., Dennis E. A. 2011. High sensitivity quantitative lipidomics CH:CHROMATOGRAPHY_SUMMARY analysis of fatty acids in biological samples by gas chromatography-mass CH:CHROMATOGRAPHY_SUMMARY spectrometry. Biochim. Biophys. Acta. 1811: 648-656. CH:INSTRUMENT_NAME Multiple CH:COLUMN_NAME Multiple CH:CHROMATOGRAPHY_TYPE Core G #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:MS_COMMENTS - MS:INSTRUMENT_NAME - MS:INSTRUMENT_TYPE - MS:MS_TYPE Other MS:ION_MODE UNSPECIFIED #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS pmol/mg MS_METABOLITE_DATA_START Samples NASH001 NASH002 NASH003 NASH004 NASH005 NASH006 NASH007 NASH009 NASH010 NASH011 NASH012 NASH013 NASH014 NASH015 NASH016 NASH017 NASH018 NASH019 NASH020 NASH021 NASH022 NASH023 NASH024 NASH026 NASH027 NASH028 NASH029 NASH030 NASH031 NASH032 NASH033 NASH034 NASH035 NASH036 NASH037 NASH038 NASH039 NASH040 NASH041 NASH042 NASH043 NASH044 NASH045 NASH046 NASH047 NASH048 NASH049 NASH050 NASH051 NASH052 NASH053 NASH054 NASH055 NASH056 NASH057 NASH058 NASH059 NASH060 NASH061 NASH062 NASH064 NASH065 NASH066 NASH067 NASH068 NASH069 NASH070 NASH071 NASH072 NASH073 NASH074 NASH075 NASH076 NASH077 NASH078 NASH079 NASH080 NASH081 NASH082 NASH083 NASH084 NASH085 NASH086 NASH087 NASH088 NASH089 NASH090 NASH091 Factors Diagnosis:Steatosis Diagnosis:Steatosis Diagnosis:Normal Diagnosis:Normal Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:NASH Diagnosis:Normal Diagnosis:NASH Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:NASH Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:NASH Diagnosis:NASH Diagnosis:Normal Diagnosis:NASH Diagnosis:Cirrhosis Diagnosis:Steatosis Diagnosis:Normal Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:NASH Diagnosis:NASH Diagnosis:Steatosis Diagnosis:Steatosis Diagnosis:Normal Diagnosis:NASH Diagnosis:Normal Diagnosis:NASH Diagnosis:NASH Diagnosis:NASH Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:Normal Diagnosis:Normal Diagnosis:NASH Diagnosis:Normal Diagnosis:Normal Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:Normal Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:Normal Diagnosis:Cirrhosis Diagnosis:Steatosis Diagnosis:NASH Diagnosis:Steatosis Diagnosis:Steatosis Diagnosis:Normal Diagnosis:Steatosis Diagnosis:Steatosis Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:Normal Diagnosis:Cirrhosis Diagnosis:Cirrhosis Diagnosis:Normal Diagnosis:Steatosis Diagnosis:NASH Diagnosis:Steatosis Diagnosis:NASH Diagnosis:Steatosis Diagnosis:Steatosis Diagnosis:Normal Diagnosis:Normal Diagnosis:Steatosis Diagnosis:Normal Diagnosis:Steatosis Diagnosis:Normal Diagnosis:Steatosis Diagnosis:NASH Diagnosis:Normal Diagnosis:Normal Diagnosis:NASH Diagnosis:NASH Diagnosis:Normal Diagnosis:NASH Diagnosis:Normal 6k PGF1a 0.07348 0.49514 0.35913 0.08333 0.29451 0.00472 0.03695 1.37996 0.16500 0.13929 0.57017 0.67549 0.27102 0.08258 0.60206 0.19012 0.29776 0.18522 0.01756 0.01277 0.12825 0.01141 0.01039 0.09558 0.05933 0.04407 0.16030 0.02539 NA 0.06706 NA 0.04866 0.02179 NA 0.00618 NA NA 0.02988 NA 0.22569 0.19425 0.23031 0.12203 0.13924 0.35923 0.27290 0.77347 NA 0.03339 0.56522 0.57824 0.05394 0.07645 0.20534 0.50188 NA 0.10553 0.38381 0.46386 0.38588 1.00993 0.24275 0.26735 0.46950 0.17062 0.13050 0.05637 0.07139 0.18078 0.20411 0.14249 0.09438 0.07761 0.12019 0.28617 0.11957 0.05456 0.05221 0.00605 0.02139 0.12271 0.03557 0.05554 0.06611 0.04953 0.05477 0.05198 0.03022 TxB2 0.04844 0.35306 0.28417 NA NA NA NA 0.36495 0.01717 NA 0.14796 0.18884 0.19466 NA 0.08739 0.08687 0.26168 0.19868 0.05832 0.00745 0.09797 0.00806 0.03334 0.07224 0.02408 0.13505 0.04959 0.05245 0.01563 0.07136 0.01430 0.05484 0.01807 0.03911 0.03032 0.02284 0.00706 0.00871 0.01214 0.13088 0.28825 0.22089 0.12535 0.07758 0.18999 0.10497 0.32577 0.02494 0.03485 0.15306 0.31371 0.02283 0.08397 0.14478 0.10702 0.02699 0.08318 0.26940 0.42212 0.37237 0.30300 0.06528 0.10520 0.29026 0.06665 0.07449 NA 0.00313 0.07859 0.07667 0.02803 0.02303 0.04384 0.07578 0.07826 0.05993 0.02974 0.00958 0.00787 0.02375 0.07893 0.02285 0.07289 0.04538 0.04319 0.07579 0.01247 0.04618 PGE2 0.04247 0.19437 0.27167 0.06293 0.04145 0.01768 0.01618 0.06976 0.14373 0.10186 0.21596 0.05369 0.22836 0.04326 0.05966 0.11817 0.14050 0.10959 0.02348 0.00252 0.01792 0.00702 0.01144 0.01746 NA 0.04833 0.02553 0.01906 0.00503 0.05595 0.00756 0.02891 0.02005 0.04034 0.00491 0.00552 0.02708 0.00714 0.01455 0.08722 0.15617 0.11023 0.08518 0.10021 0.04165 0.05049 0.07756 0.05896 0.04394 0.10109 0.05537 0.03854 0.08175 0.13710 0.09472 0.01472 0.07219 0.15359 0.26850 0.12193 0.05366 0.07684 0.12435 0.15822 0.05483 0.05554 0.01675 0.01399 0.04570 0.04182 0.04576 0.02778 0.02423 0.05034 0.06966 0.04662 0.02271 0.03117 0.03536 NA 0.02172 0.02243 0.09355 0.06231 0.04888 0.02024 0.03022 0.01956 PGD2 0.03190 0.14895 0.21756 0.01723 0.02515 0.00352 NA 0.06812 0.09549 0.06445 0.21255 0.05840 0.12019 0.01040 0.03326 0.07016 0.07365 0.05286 0.01440 NA 0.02302 NA NA NA NA NA NA 0.01412 NA 0.02917 NA 0.01248 0.01270 0.02200 0.00299 0.01341 NA 0.00185 0.00162 0.07847 0.12321 0.07493 0.05894 0.06930 0.01653 0.02885 0.07968 0.02304 0.01905 0.13326 0.01404 NA 0.06832 0.07275 0.11774 0.00719 0.06509 0.17859 0.15369 0.08795 0.07566 0.03652 0.08029 0.10094 0.07923 0.07709 0.01172 0.01150 0.01579 0.01923 0.01648 0.01648 0.00640 0.01360 0.02617 0.00591 0.00577 0.00098 NA NA 0.02521 0.01757 0.00394 0.08414 0.03961 0.01662 0.01163 0.02401 PGF1a NA 0.12510 0.03658 0.05148 0.01795 0.04087 0.02366 0.03738 0.01778 0.05423 0.04379 0.04189 0.04825 0.03821 0.03805 0.04655 0.00302 NA 0.00915 0.00664 NA 0.00864 NA NA 0.00318 0.03562 0.01339 0.00998 NA NA 0.00263 0.00181 0.00043 0.00094 NA 0.00160 0.00791 0.00259 0.00284 0.01052 0.01964 NA NA NA NA NA 0.00298 0.00416 0.00910 NA NA 0.01293 0.01701 NA 0.08487 0.00453 0.00512 0.02122 0.02005 NA NA 0.00332 0.00511 0.00218 NA 0.00482 0.04184 0.00922 0.05642 0.05632 0.06132 0.01025 0.04559 0.03440 0.05487 0.02109 0.01288 0.02424 NA NA NA NA 0.09750 NA NA NA NA NA 6k PGE1 0.02580 NA NA NA 0.08750 NA NA 0.11543 NA NA 0.01240 0.12294 0.00728 NA 0.20543 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.00024 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.00014 0.00395 NA NA NA NA NA NA NA NA NA NA NA NA NA 0.10981 0.02423 0.01153 0.00800 0.15163 0.01796 0.01075 NA 0.00506 0.00565 6,15 dk-,dh- PGF1a NA NA NA NA 0.26132 NA NA 0.84076 NA NA 0.01858 0.88130 NA NA 0.23052 NA 0.05604 0.19560 NA 0.13273 NA 0.01843 0.16986 0.01649 0.25003 0.06412 0.25579 0.13373 0.00076 0.00694 0.23508 0.34763 0.11001 0.30837 NA NA NA NA 0.27524 NA NA 0.05612 0.15914 0.04970 0.34940 NA 0.35102 0.05244 0.06568 1.04725 0.26990 NA NA NA NA 0.10499 NA 0.00314 0.01018 NA 0.03318 0.20241 0.17421 0.10669 0.15069 NA NA 0.02859 NA NA 0.02087 NA NA NA 0.07195 NA NA NA NA NA NA 0.00923 NA NA NA NA NA NA 15k PGF2a NA 0.16253 0.14751 0.05902 0.04225 0.01051 0.00034 0.03740 0.00120 0.05184 0.05450 0.03372 0.06179 0.02482 0.13366 0.04339 0.00233 0.00878 NA NA NA NA NA NA 0.00710 0.00977 NA NA 0.01440 NA NA 0.00433 NA 0.00484 0.00032 0.00387 0.00037 NA NA NA 0.02829 NA NA NA 0.02506 NA 0.00675 NA NA 0.07171 NA NA NA 0.01896 NA 0.00810 NA NA NA NA NA NA 0.00971 0.02209 NA 0.05145 NA NA NA NA NA NA NA 0.00978 NA NA NA NA 0.06767 NA NA NA 0.13103 0.04298 0.01430 0.02922 NA NA 15k PGE2 0.04549 0.29577 0.21554 0.08113 0.05549 0.01167 0.01030 0.05335 0.01422 0.15339 0.07332 0.07522 0.12552 0.05331 0.07930 0.06470 0.07147 0.02285 NA NA 0.01549 NA NA NA NA NA 0.01266 0.01188 0.00561 0.02217 NA NA NA 0.01394 0.00196 0.00246 NA 0.00948 0.01226 0.04926 0.07009 0.03279 0.03476 0.05186 0.07779 0.05037 0.03824 NA NA 0.12864 0.03552 0.01540 0.00959 0.12922 0.02706 0.02934 0.01972 0.01193 0.06263 0.06299 0.04607 0.01796 0.03692 0.08316 0.06001 0.11210 0.00173 0.01863 0.03499 0.00936 0.00159 0.01606 0.01714 0.04453 0.01188 0.01999 0.02136 0.03745 0.00587 0.00649 0.01293 0.01133 0.12134 0.01945 0.13035 0.00196 0.00921 0.01193 dhk PGF2a 0.01565 0.01733 0.03653 0.01591 0.01518 0.00600 NA 0.06223 NA 0.02138 0.04371 0.07076 0.02614 0.01034 0.03403 0.02876 0.01406 NA NA NA 0.01793 NA 0.01690 NA NA 0.04556 NA NA NA 0.00571 NA 0.00380 NA 0.02466 0.03440 NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.11221 NA NA NA 0.01426 NA NA NA NA NA NA NA NA NA NA NA NA 0.00109 0.01677 0.01361 0.01166 0.00720 0.00296 0.01433 0.00731 NA NA 0.00077 0.00431 NA NA NA 0.02111 0.02676 NA 0.00428 0.00278 0.00059 0.01215 dhk PGE2 NA 0.22814 0.32085 0.07046 0.05524 NA NA 0.13421 0.13910 0.11917 0.37925 0.13638 0.36379 0.02172 0.10974 0.17905 0.21722 0.23175 0.04106 0.02726 0.10403 0.00788 0.03421 0.04135 0.02776 0.09301 0.05546 0.02908 0.02996 0.10530 0.01939 0.09223 0.02226 0.04895 0.03460 0.03879 0.02818 0.02424 0.04482 0.06975 0.09533 0.14085 0.05215 0.13601 0.09632 0.05299 0.11440 0.03003 0.03108 0.19296 0.11412 0.02262 0.05945 0.14281 0.09680 0.00855 0.04586 0.09871 0.13300 0.18227 0.09744 0.05831 0.08072 0.10167 0.09374 0.09344 0.00617 0.04308 0.08273 0.06142 0.08426 0.01815 0.01143 0.04954 0.14943 0.04971 0.02740 0.04593 0.01703 NA 0.62878 NA NA NA NA NA NA NA dhk PGD2 0.01581 0.03001 0.03542 0.01997 0.05060 0.01385 0.02317 0.05164 0.02043 0.03761 0.04003 0.06296 0.03906 0.01844 0.03678 0.02379 0.01180 0.03624 0.01449 0.00936 0.02207 0.01095 0.01648 0.02181 0.02137 0.04493 0.02202 0.02833 0.01401 0.01123 0.00803 0.00760 0.00755 0.02552 0.01908 0.01353 0.01382 0.01342 0.01289 0.03725 0.01999 0.03379 0.02701 0.03503 0.03411 0.03287 0.09488 0.02929 0.02266 0.07116 0.04725 0.04181 0.05432 0.04559 0.04418 0.02148 0.03215 0.04809 0.02392 0.04546 0.04143 0.05931 0.06238 0.02589 0.04676 0.04350 0.02771 0.04860 0.03587 0.02004 0.04215 0.02959 0.03363 0.02691 0.06461 0.02125 0.05198 0.05510 0.02044 0.01555 0.00855 0.01974 0.06347 0.02347 0.02511 0.01423 0.02089 0.02310 tetranor 12-HETE NA 0.01077 0.01199 0.01476 0.00174 0.00798 0.00307 0.01886 0.00027 0.04476 0.01489 0.00222 NA 0.00794 0.00825 0.00549 0.00228 0.00410 NA 0.00190 0.00278 0.00246 0.00033 0.00484 0.00344 0.00767 0.00189 0.00205 0.00114 0.00103 0.00120 0.00114 0.00062 0.00019 0.00065 0.00077 0.00233 0.00216 0.00215 NA NA NA NA NA NA NA NA NA NA NA 0.00254 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.00063 0.00103 NA NA NA 0.00051 0.00154 NA 0.00136 NA NA 0.00025 0.00116 NA NA NA 0.00048 NA 0.00111 NA 0.00004 NA 11b PGE2 0.00048 0.00128 NA NA NA NA NA NA NA NA NA NA NA NA 0.00533 NA 0.00264 0.00214 NA NA 0.00203 0.00174 0.00026 NA NA 0.00138 NA 0.00016 0.00079 0.00176 NA 0.00205 0.00156 0.00068 0.00298 0.00108 0.00169 0.00104 0.00052 NA 0.00184 NA NA 0.00175 0.00743 NA NA NA 0.00096 0.00528 NA NA 0.00097 0.00262 NA 0.00178 NA NA 0.00165 0.00327 0.00153 NA NA NA NA 0.00445 NA 0.00262 0.00693 0.00187 NA 0.00078 0.00072 NA NA 0.00277 0.00020 NA 0.00098 0.00206 0.00076 0.00213 0.00093 0.02040 0.02086 0.00070 0.00136 0.00969 12-HHTrE 0.08846 2.13948 2.33116 1.06963 0.37800 0.18980 0.13366 3.86168 0.39575 3.11702 3.41607 0.62791 2.20485 0.42399 1.85582 1.12789 1.03358 0.42513 0.06493 0.03994 0.06359 0.00936 0.04622 0.11663 NA 0.17352 0.12171 0.09648 0.02389 0.15125 0.05609 0.11574 0.07377 0.14457 0.01053 0.03755 0.07173 0.01840 0.07433 0.36158 0.41419 0.44214 0.19763 0.29040 0.30395 0.15268 0.23558 0.09798 0.07875 0.27657 0.61370 0.06403 0.19040 0.42247 0.16817 0.01657 0.22449 0.59851 0.76038 0.58130 0.35314 0.19691 0.35160 0.57936 0.10748 0.20315 0.01912 0.04307 0.07860 0.12701 0.08182 0.09095 0.05565 0.18144 0.15479 0.11922 0.04749 0.04218 0.02051 0.02176 0.07094 0.02131 0.12719 0.06614 0.01776 0.05328 0.01893 0.01892 11-HETE 0.07015 0.20479 0.14214 0.09352 0.05564 0.21955 0.04855 0.22631 0.05482 0.11108 0.13124 0.21829 0.12576 0.11162 0.12451 0.12244 0.09945 0.09030 0.00892 0.02145 0.02100 0.01758 0.00946 0.03688 0.01409 0.05258 0.03142 0.01624 0.01918 0.03223 0.01200 0.01136 0.01537 0.02873 0.00901 0.01139 0.01430 0.00809 0.01383 0.04388 0.04917 0.05760 0.05260 0.03493 0.03204 0.05332 0.06610 0.01723 0.01970 0.10685 0.11921 0.02383 0.03056 0.03639 0.06839 0.00731 0.02548 0.08158 0.07845 0.04659 0.05833 0.05336 0.05114 0.10120 0.06777 0.04212 0.00882 0.02509 0.01966 0.02413 0.04626 0.03937 0.03662 0.03381 0.03905 0.06847 0.01412 0.01323 0.16061 0.08746 0.03934 0.02349 0.04746 0.03541 0.04144 0.05525 0.02654 0.04928 11-HEPE 0.00642 NA 0.01625 0.02049 0.00115 0.01440 0.00628 0.03413 NA 0.04633 0.01394 0.00608 0.02614 0.00429 0.03508 0.01276 0.00453 0.00361 0.00432 NA NA NA NA 0.00018 0.00487 0.00026 NA 0.00325 NA 0.00100 0.00198 NA 0.01562 NA NA NA NA NA 0.00378 0.00513 0.00391 0.01931 0.02274 0.00528 0.00714 0.02485 0.02938 0.05539 0.02308 0.08151 0.00722 0.03255 0.11625 0.01155 0.00936 0.01965 0.06180 0.01783 0.14650 0.03245 0.01528 0.01148 0.03754 0.01260 0.03738 0.00957 0.00057 0.00567 0.00041 NA 0.01524 0.00119 0.00098 0.00035 0.00111 0.01423 0.00003 0.00840 0.02481 0.00969 0.00109 NA 0.02083 0.00539 0.00666 0.00745 0.01074 0.00425 13 HDoHE NA 0.04515 0.01103 0.02139 0.00732 0.02447 0.00324 0.01441 0.00605 0.02905 0.03143 0.01010 0.01627 0.03242 0.02484 0.01373 0.03952 NA NA NA NA NA NA NA NA NA NA NA NA 0.00567 NA NA NA 0.00110 NA NA NA NA NA 0.01083 0.01304 NA 0.02722 0.00487 0.00053 0.02003 0.00268 0.00811 0.02155 0.00153 0.03769 0.01732 0.00101 0.00515 0.02053 0.00114 NA 0.01872 0.00637 0.01468 0.00475 0.00568 0.01289 0.01207 0.00488 0.00476 NA 0.00009 0.00013 0.00830 NA 0.01292 0.00900 0.00704 0.01395 NA 0.00143 0.00889 0.02744 0.00433 NA NA 0.04592 0.00128 0.01328 NA NA NA PGA2 0.00599 0.04824 0.06956 0.00865 0.02593 0.00512 0.01032 0.02695 0.04053 0.06225 0.04118 0.01742 0.04222 0.01246 0.00633 0.02724 0.00323 0.01053 0.00282 0.00792 0.00854 0.00349 0.00687 0.00811 0.00459 0.01067 0.01575 0.00776 0.01274 0.00560 0.00735 0.00564 0.00846 0.01044 0.00922 0.00621 0.00620 0.00547 0.00807 0.00305 0.00638 0.00763 0.00246 0.00636 0.00502 0.00099 0.01330 0.00169 0.00027 0.00451 0.00208 0.00007 0.00500 0.00620 0.00224 0.00355 0.00975 0.02211 0.01343 0.02164 0.00286 0.00829 0.01139 0.00106 0.00726 0.00425 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.00547 0.00372 0.01111 0.00393 NA 0.00586 NA PGJ2 0.01149 0.04337 0.04760 0.02437 0.00474 0.00287 0.00269 0.02846 0.01459 0.07866 0.10477 0.01072 0.02543 0.01342 0.01428 0.01966 0.00260 0.00551 0.00201 0.00192 0.00274 0.00137 0.00160 0.00257 0.00205 0.00364 0.00168 0.00160 0.00113 0.00193 0.00324 0.00265 0.00212 0.00262 0.00186 0.00208 0.00314 0.00310 0.00404 0.00173 0.00614 0.00290 0.00891 0.00218 0.00361 0.00224 0.00711 0.01508 0.00673 0.00335 0.00078 0.00181 0.00514 0.00205 0.00001 0.00823 0.00288 0.00737 0.00982 0.00271 0.00500 0.00378 0.00264 0.00478 0.00386 0.00212 0.00057 NA NA 0.00009 NA NA NA NA 0.00317 0.00036 0.00153 0.00035 0.00544 0.00888 0.00484 0.00489 0.02002 0.00402 0.00397 0.00622 0.00373 0.00601 15d PGD2 0.00532 0.01468 0.01864 0.01445 0.00018 0.00629 NA 0.01452 0.00372 0.03015 0.03098 0.00558 0.01326 0.00434 0.00838 0.01004 0.00329 0.00145 0.00117 0.00077 0.00128 0.00149 0.00131 0.00235 0.00085 0.00424 0.00246 0.00079 0.00042 0.00273 0.00255 0.00764 0.00170 0.01518 0.00267 0.00238 0.00382 0.00393 0.02285 NA NA NA NA NA NA NA NA 0.00190 NA 0.00132 NA NA NA 0.00172 0.00004 NA 0.00077 0.00210 0.00304 NA NA NA NA NA NA NA NA 0.00019 NA 0.00007 NA NA NA NA 0.00034 NA NA 0.00372 0.00452 0.00540 0.00050 0.00101 0.00343 0.00929 0.01736 0.00152 NA 0.00328 5-iso PGF2a VI NA 1.47656 1.12351 0.00191 0.00433 0.00057 0.00302 0.06077 0.15113 0.00602 1.39651 0.07336 1.84976 0.73962 0.14710 0.69098 NA NA NA NA NA NA NA NA NA NA NA NA 1.77281 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.00756 NA NA NA NA NA NA NA 0.00239 NA NA NA NA NA NA NA NA NA 0.00383 0.00537 0.00710 NA NA NA 0.00412 NA NA NA NA 0.00093 NA NA 0.00577 NA NA NA NA NA 0.00571 NA NA NA NA NA 8-iso PGF2a III NA 0.39694 0.49569 0.04262 0.07800 0.02626 0.02243 0.11215 0.12159 0.12867 0.29648 0.07557 0.24533 0.06858 0.15182 0.22282 0.00210 0.00402 NA NA 0.01357 NA 0.00816 NA 0.00103 NA 0.00540 NA NA 0.03782 NA 0.02479 0.00472 0.02668 0.00581 NA NA 0.01502 0.01911 NA NA NA 0.00576 0.01292 0.03677 NA 0.00709 0.00335 NA 0.15967 NA NA NA NA NA NA NA NA NA 0.01006 NA NA NA 0.00161 0.00605 NA 0.00273 0.02224 NA 0.00618 0.00110 0.00325 0.00926 0.04060 NA 0.01530 0.00316 0.00094 NA NA NA NA NA NA NA NA NA NA 9-HETE 0.02246 0.04730 0.01733 0.01722 0.00388 0.02474 0.01701 0.08699 0.01047 0.02999 0.00872 0.01289 0.04498 0.05926 0.06008 0.01109 0.04803 0.00414 0.00011 0.01330 0.00531 NA NA 0.01523 0.00423 0.00980 0.01374 0.00905 0.00458 0.01330 0.00216 0.00243 0.00284 0.00783 0.00098 0.00057 0.00879 0.00884 0.00710 0.01394 0.01322 0.01257 0.01260 0.01397 0.00761 NA 0.00922 0.00446 0.00510 0.03368 0.02261 0.00919 0.01410 0.00213 0.00564 0.00232 NA 0.00516 0.01563 0.01359 0.00005 0.00070 0.01777 0.01623 0.01815 0.01551 0.00017 NA 0.00490 0.00874 0.00733 0.00971 0.01111 0.00558 0.00824 0.00891 0.00367 0.01058 0.01345 0.00509 0.00879 0.00309 0.04081 0.02553 0.00726 0.00248 0.00521 0.00558 9-HEPE 0.00341 0.31568 0.10553 0.11722 0.00848 0.02684 0.00160 0.01775 0.02578 0.22101 0.19644 0.10278 0.07463 0.00521 0.06476 0.05541 0.03105 NA NA NA NA 0.00169 0.00035 0.00264 NA NA NA NA NA 0.00099 0.00241 0.00132 0.00121 0.01303 NA NA 0.00607 0.01522 0.01284 0.01455 0.02942 0.06256 0.03617 0.00429 NA 0.02549 0.02246 0.00524 0.01887 0.01160 0.09297 0.02594 0.00174 0.01429 0.03749 NA 0.01091 0.05491 NA 0.08212 NA 0.06144 0.02111 0.00512 0.00339 0.00042 0.00320 NA NA NA NA 0.00033 0.00050 0.00387 0.00446 0.00221 NA 0.00286 NA 0.00156 0.00043 NA 0.01094 0.00243 0.00214 NA 0.00256 NA 16 HDoHE 0.01572 0.04514 0.00671 0.01926 0.00034 0.01646 0.00187 0.00735 0.00578 0.00938 0.01022 0.01197 0.01349 0.02945 0.02151 0.00789 0.05004 0.00875 NA 0.00370 0.00256 0.00137 0.00324 0.00207 0.00007 0.00213 0.00081 0.00306 0.00132 0.00768 0.00176 0.00177 0.00296 0.00247 0.00147 0.00160 0.00074 NA 0.00298 0.00136 0.00551 0.00409 0.00584 0.00292 NA 0.00480 0.00050 NA 0.00230 0.00439 0.01633 0.00975 NA 0.00527 0.00547 0.00228 0.00034 0.00750 0.00480 0.00374 0.00322 0.00311 0.00309 0.00735 0.00313 0.00363 0.00370 0.00713 0.00322 0.01068 0.00474 0.00714 0.01227 0.00888 0.01757 0.00861 0.00481 0.01063 0.01456 0.01816 0.00470 0.00184 0.00680 0.01107 0.00750 0.00119 0.00197 0.00547 20 HDoHE 0.03043 0.09149 0.00882 0.06879 NA 0.02216 NA 0.00862 0.00434 0.04438 0.02754 0.02007 0.03769 0.04058 0.00760 0.02081 0.06613 0.02539 NA 0.01381 0.00065 NA NA NA 0.01705 0.01923 NA 0.01679 0.01853 0.04236 NA NA NA 0.03190 NA NA NA NA 0.00177 NA 0.00138 0.01770 0.01748 0.00696 NA 0.00505 0.00327 0.00361 0.00051 0.02423 0.04979 0.01846 0.00906 0.00117 0.01353 0.00064 NA 0.01623 0.01401 NA 0.00665 0.00786 NA 0.01997 0.01743 0.01358 0.00301 0.00389 0.00211 0.00343 0.00346 0.01466 0.00616 0.01520 0.01169 0.00466 NA 0.00435 0.03026 0.03487 0.02129 0.00146 0.03119 0.01595 0.01950 0.00863 0.00237 0.01391 LTE4 0.00170 NA NA NA NA NA NA 0.04086 NA NA 0.00025 0.05994 NA NA 0.00772 NA 0.00024 0.00010 NA NA 0.00114 0.00004 NA 0.00140 0.00658 0.00281 0.00317 0.00003 NA NA NA NA NA NA NA 0.00085 NA NA NA NA NA NA NA NA 0.00112 0.00082 0.01646 NA NA 0.00087 0.00071 NA 0.00128 NA NA NA NA NA NA NA 0.00881 NA 0.00120 NA NA NA 0.00142 0.00045 0.00122 0.00055 0.00223 0.00096 0.00029 0.00028 0.00018 0.00026 0.00028 0.00010 0.00259 0.00099 0.00079 0.00040 0.00168 0.00049 0.00165 0.00091 0.00204 NA 5-HETE 0.12730 0.15482 0.09371 0.11900 0.01871 0.08691 0.04932 0.09203 0.02596 0.12139 0.11068 0.09078 0.07281 0.11463 0.07101 0.09916 0.05997 0.10091 0.00723 0.01863 0.00640 0.01148 0.00585 0.02551 0.00853 0.03555 0.02378 0.01028 0.02385 0.03817 0.01364 0.00995 0.00698 0.02331 0.00670 0.00679 0.00814 0.00553 0.01763 0.04016 0.02913 0.04670 0.03323 0.03039 0.01714 0.02075 0.01503 0.00964 0.01928 0.04443 0.04503 0.02845 0.01741 0.02559 0.03427 0.01074 0.01522 0.06308 0.03394 0.02846 0.02126 0.04488 0.03183 0.05954 0.03889 0.01920 0.00891 0.01931 0.00849 0.02962 0.03657 0.04950 0.02437 0.02043 0.03455 0.04366 0.01381 0.01954 0.36519 0.19621 0.07005 0.04301 0.09530 0.05655 0.09163 0.09851 0.04662 0.11603 4 HDoHE 0.05357 0.08532 0.03197 0.09362 0.00188 0.06185 0.01068 0.01233 0.00564 0.02611 0.05571 0.04293 0.05562 0.04541 0.04540 0.05429 0.04151 0.06749 0.01076 0.01439 NA 0.00646 0.01289 0.00762 0.00895 0.04153 0.00865 0.01611 0.00978 0.02758 0.01043 0.00470 0.00645 0.01238 0.00597 0.01241 0.01218 0.01538 0.01042 0.02705 0.01402 0.01935 0.02423 0.01913 NA 0.00814 0.00644 0.01575 0.02495 0.02987 0.03361 0.01446 0.00863 0.01063 0.02405 0.00435 0.01307 0.05232 0.01016 0.01301 0.01089 0.01171 0.01834 0.05822 0.01878 0.01641 0.00268 NA NA 0.01142 0.00065 0.02597 0.01369 0.00650 0.01699 0.01934 NA 0.00589 0.22090 0.18392 0.04394 0.02061 0.01922 0.07767 0.11267 0.14691 0.02620 0.06053 9-HOTrE 0.02778 0.06673 0.01110 0.04952 0.00896 0.01598 0.01175 0.01595 0.02282 0.07967 0.05231 0.01665 0.01783 0.03607 0.01600 0.01455 0.01663 0.00503 0.00112 0.00983 0.00497 0.00520 0.00222 0.00739 0.00166 0.00267 0.00387 0.00746 0.00481 0.00995 0.00371 0.00800 0.00878 0.00316 0.00651 0.00527 0.00215 0.00608 0.00462 0.00323 0.00462 0.00847 0.00681 0.00041 0.00245 0.00310 NA 0.00155 0.00215 0.00231 0.02151 0.00475 0.00184 0.00518 0.00713 0.00196 0.00430 0.00812 0.00884 0.01605 0.00315 0.00287 0.00959 0.00673 0.00337 0.00336 NA NA NA NA NA NA NA NA 0.00211 NA NA NA 0.00438 0.01928 0.01293 0.01316 0.01203 0.00964 0.01190 0.00741 0.00702 0.00680 15-HETE 0.12967 0.27352 0.23991 0.16754 0.05638 0.12758 0.05883 0.16610 0.10844 0.16838 0.30161 0.18082 0.11181 0.15871 0.27440 0.13891 0.14690 0.31457 0.04570 0.05258 0.02461 0.03737 0.02446 0.04768 0.01452 0.06148 0.22157 0.03896 0.17665 0.12147 0.01565 0.02819 0.04799 0.01698 0.01196 0.06985 0.02179 0.01251 0.01881 0.11675 0.13907 0.08542 0.06489 0.08968 0.03794 0.05419 0.12012 0.02396 0.04769 0.17621 0.32107 0.06102 0.07110 0.05719 0.10296 0.02863 0.03886 0.13357 0.32694 0.16108 0.06489 0.12786 0.16196 0.12642 0.08753 0.04940 0.02096 0.29511 0.05005 0.02738 0.04525 0.08860 0.11351 0.08639 0.24418 0.10478 0.05032 0.03629 0.19752 0.13754 0.10875 0.14016 0.10805 0.12273 0.09426 0.04735 0.09399 0.06571 15-HEPE NA 0.03856 0.04313 0.02721 0.00146 0.00004 0.00062 0.01979 0.00958 0.02061 0.09659 0.01596 0.01574 0.00742 0.05414 0.01255 0.00841 0.01276 0.00785 0.00599 0.00197 0.00835 0.00137 0.00461 0.00340 0.00447 0.01424 0.00505 0.01174 0.00797 0.00116 0.00413 0.00798 0.00615 0.00449 0.00714 0.00505 0.00157 0.00340 0.00716 0.01348 0.01516 0.01169 0.00722 NA 0.00695 0.00371 NA 0.00002 0.01266 0.06501 0.01239 0.00946 0.00850 0.00885 NA 0.00184 0.01468 0.01898 0.02596 0.00341 0.01548 0.01291 0.00419 0.00634 0.00005 NA 0.02650 NA NA 0.00437 0.00070 0.01218 0.00344 0.01496 0.01548 0.00283 0.00310 0.00065 NA 0.00775 0.00837 0.01059 NA 0.00504 0.00023 0.00194 NA 13-HODE 0.95087 1.78061 0.37759 0.46580 0.21496 0.27533 0.20407 0.29511 0.49015 0.74750 0.61304 0.51643 0.22895 0.47395 0.36931 0.20778 0.41960 0.37795 0.10063 0.22024 0.27053 0.17402 0.16219 0.28698 0.09963 0.30628 0.37853 0.18300 0.34661 0.38863 0.10342 0.20987 0.27509 0.14416 0.23208 0.27851 0.12269 0.16076 0.11226 0.21313 0.27386 0.34685 0.16034 0.22611 0.12858 0.22549 0.15033 0.09153 0.12642 0.29104 0.58518 0.18750 0.13572 0.25294 0.30193 0.07727 0.17527 0.37201 0.60098 0.54730 0.18934 0.26962 0.29345 0.24651 0.18187 0.16262 0.10251 0.30138 0.23413 0.14887 0.13291 0.15582 0.27278 0.15783 0.36712 0.24018 0.17221 0.14617 0.29238 0.47962 0.43558 0.61545 0.35023 0.39467 0.42355 0.25583 0.28214 0.22937 15-HETrE 0.01726 0.01849 0.02042 0.00406 0.12617 0.00566 0.21890 0.15164 0.02713 0.00491 0.03003 0.05070 0.00215 0.01464 0.15177 0.00374 0.02570 0.02042 0.00548 0.00573 0.00657 0.00395 0.00548 0.00429 0.00315 0.01353 0.12191 0.00713 0.01249 0.02334 0.00243 0.00632 0.00605 0.00785 NA 0.00707 NA NA 0.00472 0.00542 0.00979 0.00679 0.00895 0.01644 0.00615 0.00343 0.01009 NA NA 0.01691 0.01961 0.00383 0.00520 0.01223 0.00709 NA NA 0.00819 0.03035 0.01453 0.01296 0.01393 0.01057 0.00472 0.01000 0.00746 0.00141 0.03503 0.00353 0.00253 0.00787 0.00446 0.02076 0.00345 0.03553 0.01240 0.00705 NA 0.02246 0.01481 0.01929 0.02037 0.04325 0.01790 0.01393 0.00680 0.01917 0.01837 8-HETE 0.01651 0.08699 0.03158 0.04088 NA 0.02165 0.02046 0.00394 0.00739 0.00412 0.03028 0.03100 0.03271 0.06032 0.03975 0.02175 0.04472 0.03421 0.00903 0.01201 0.00121 NA 0.00625 0.00917 0.00642 0.01186 0.01221 0.00570 0.00462 0.01969 0.00701 0.00125 0.00437 0.00709 0.00285 0.00685 0.00604 0.00100 0.01346 0.02421 0.03046 0.02778 0.02758 0.02555 0.03190 0.02449 0.02362 0.00088 0.02051 0.04259 0.05404 0.02432 0.02657 0.01577 0.01728 0.01281 0.01039 0.03715 0.03310 0.02660 0.01797 0.03365 0.03223 0.02773 0.02984 0.02700 NA 0.00444 0.00484 0.00881 0.01348 0.01882 0.00750 0.01184 0.01499 0.01273 0.00841 0.00971 0.01055 0.00955 0.00518 0.00213 0.00340 0.02115 0.00382 NA 0.00008 0.00330 10 HDoHE 0.00419 0.01396 0.00285 0.00705 0.00020 0.00471 0.00158 0.00463 0.00063 NA 0.00740 0.00435 0.00763 0.01377 0.01151 0.00090 0.02084 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.00265 NA NA NA NA NA NA NA NA NA NA NA NA 0.00022 0.00038 0.00189 NA 0.00321 0.00533 0.00152 0.00150 0.00237 0.00059 0.00167 0.00073 0.00641 0.00667 0.00143 0.02844 0.02243 0.00915 0.00366 0.00208 0.00144 12-HETE 0.21391 0.24542 0.62768 0.04060 0.01942 0.14732 0.04743 0.11925 0.09567 0.21664 0.52940 0.16523 0.11441 0.12682 0.11965 0.18012 0.21006 0.32825 0.20402 0.21352 0.07259 0.11536 0.27157 0.11420 0.14530 0.28413 0.04424 0.24462 0.28628 0.53770 0.01790 0.17204 0.24291 0.20984 0.09556 0.15589 0.19042 0.05698 0.07788 0.11715 0.46968 0.23280 0.11278 0.18911 0.07723 0.10865 0.08560 0.15529 0.12660 0.10765 0.82325 0.27124 0.09245 0.14273 0.11876 NA 0.15241 0.29226 0.73994 0.24838 0.16428 0.20944 0.28965 0.16929 0.09559 0.06127 0.26430 0.34946 0.28397 0.41028 0.15006 0.22271 0.76575 0.34476 0.79957 0.41782 0.12651 0.49886 0.30428 0.41904 0.25748 0.19395 0.16674 0.13845 0.39255 0.17772 0.10539 0.25188 12-HEPE 0.00583 0.03686 0.18103 0.02082 0.00170 0.01060 0.00191 0.01864 0.01207 0.05087 0.10548 0.01154 0.01952 0.01991 0.02342 0.01816 0.00473 0.00721 0.04017 0.00865 0.00660 0.01123 0.02066 0.00512 0.00295 0.01542 0.00380 0.02416 0.01979 0.02932 0.00433 0.02117 0.01040 0.01936 0.01295 0.00705 0.00366 0.00526 0.00571 0.02007 0.06285 0.02750 0.01412 0.02125 0.00032 0.00935 0.00446 0.02219 0.02569 0.01047 0.27320 0.03540 0.02095 0.00817 0.00623 0.00461 0.01821 0.03446 0.06300 0.03447 0.01299 0.01495 0.03997 0.01330 0.01201 0.00733 0.03434 0.02702 0.01201 0.01906 0.01683 0.00797 0.05297 0.01624 0.04886 0.04236 0.01741 0.09960 0.00854 0.02398 0.01202 0.01842 0.00227 0.00323 0.03719 0.01352 0.01168 0.02574 14 HDoHE 0.03243 0.07783 0.03451 0.01771 0.00839 0.03014 0.00492 0.01936 0.01582 0.01016 0.03965 0.01531 0.02700 0.03012 0.03199 0.00761 0.06357 0.03598 0.01049 0.00969 NA 0.00340 0.02043 NA NA NA NA 0.02311 0.02698 0.02992 NA 0.01372 0.01065 0.00963 0.01239 0.01106 0.00777 NA NA 0.01664 0.04175 0.02227 0.01770 0.03141 0.00471 0.00499 0.01218 0.00644 0.01144 0.02508 0.16811 0.03920 0.00496 0.01007 0.02360 0.00736 0.01507 0.04415 0.10292 0.03812 0.00232 0.01272 0.02805 0.02871 0.01568 0.00242 NA 0.04324 0.00279 0.02667 0.00072 0.00870 0.06798 0.03372 0.07231 0.02994 0.01035 0.03451 0.03066 0.03794 0.02051 0.03255 0.02294 0.03408 0.03280 0.01679 0.01238 0.01655 11 HDoHE 0.00617 0.03174 0.00958 0.00593 0.00271 0.05614 0.00784 0.03434 0.00303 0.01793 0.02391 0.00861 0.01333 0.03302 0.02120 0.01284 0.02260 0.00857 NA 0.00473 NA 0.00351 0.00071 NA NA NA NA 0.00398 0.00166 0.00470 NA 0.00488 0.00624 0.00884 NA NA NA NA NA 0.00600 0.02054 0.01020 0.02115 0.01072 0.00653 0.01549 0.01189 0.00265 0.00751 0.02317 0.15263 0.01830 0.00343 0.00885 0.01865 NA 0.00737 0.03027 0.03543 0.01280 0.00369 0.01844 0.00649 0.03449 0.01077 0.01869 0.00414 0.00433 0.00596 0.00903 0.01129 0.00737 0.01596 0.00938 0.01685 0.00716 0.00208 0.02655 0.01842 0.01902 0.01049 0.00151 0.02371 0.03326 0.00267 0.00232 NA 0.00584 9-HODE 1.24588 2.93961 0.48568 0.54217 0.29434 0.26214 0.16544 0.37060 0.57782 1.43558 0.78970 0.64440 0.31859 0.51630 0.37489 0.24320 0.76266 0.46572 0.15510 0.30554 0.44754 0.18524 0.18674 0.48212 0.11189 0.36035 0.18529 0.24572 0.26306 0.42299 0.08829 0.42299 0.35957 0.19800 0.37279 0.30539 0.15000 0.19103 0.12912 0.27910 0.36212 0.55832 0.25313 0.18419 0.22949 0.29676 0.21614 0.09461 0.10142 0.34750 0.69712 0.19510 0.16423 0.40646 0.43495 0.09083 0.25262 0.44717 0.59870 0.75913 0.28787 0.29717 0.37557 0.32069 0.19532 0.17838 0.08585 0.13299 0.23232 0.15784 0.15901 0.15283 0.29207 0.16437 0.23608 0.22071 0.13994 0.17500 0.30753 0.80188 0.66417 0.65503 0.50003 0.43498 0.59217 0.37327 0.23922 0.31092 HXB3 0.20083 0.15393 4.20723 0.21290 0.01727 0.55566 0.11585 0.27982 0.09371 0.24986 1.72717 0.24382 0.65324 0.28378 0.41331 0.18444 0.06945 0.06428 0.01247 0.09666 0.01137 0.01716 0.04574 0.01492 0.00016 0.08169 NA 0.05623 0.06122 0.04949 NA 0.01147 0.03602 0.02100 0.01609 0.00725 0.00359 0.01018 0.02172 0.04462 0.05667 0.07065 0.03884 0.06181 0.00966 NA NA 0.02528 0.05517 0.10970 0.06248 0.05061 0.02932 0.05262 0.11390 0.03994 0.03800 0.12715 0.17197 0.04313 0.02247 0.04521 0.08707 0.08893 0.06261 0.02732 0.11405 0.11021 0.02926 0.06553 0.04473 0.17571 0.36938 0.16185 0.25261 0.08027 0.02238 0.24511 0.67660 1.01124 0.19068 0.39816 0.10339 0.31633 1.39686 0.36565 0.24778 0.43267 5-oxoETE 0.05603 0.05167 0.02067 0.07090 NA 0.03247 0.01200 0.05326 0.00885 0.02807 0.04658 0.11052 0.03437 0.04853 0.03513 0.04357 0.04546 0.05241 NA 0.00890 0.00949 0.00612 NA 0.00703 0.01010 0.05211 0.00418 0.00171 NA 0.01210 NA NA 0.00047 0.00170 0.00086 NA NA 0.00073 0.00367 0.02684 0.02029 0.02094 0.00586 0.02067 0.00472 0.01592 0.00830 0.02019 0.00832 0.03945 0.02854 0.00957 0.00380 0.02269 0.01234 0.00179 0.00799 0.01981 0.02125 0.01554 0.02778 0.01828 0.02504 0.04258 0.02387 0.01924 NA 0.01847 0.01920 0.01523 0.04855 0.06475 0.02892 0.04672 0.03296 0.01983 0.00811 0.01678 0.24379 0.23290 0.02984 0.01439 0.02702 0.02914 0.00532 0.04235 NA 0.02329 15-oxoETE 0.00119 0.10843 0.14041 0.07492 0.03589 0.04984 0.07394 0.20563 0.02658 0.05638 0.11120 0.12180 0.07789 0.06555 0.16713 0.09815 0.02561 0.05332 0.00873 0.02204 0.00709 0.01790 0.01395 0.01580 0.01892 0.04994 0.16844 0.01409 0.05441 0.02395 0.00293 0.00732 0.01543 0.00632 0.01192 0.01829 0.00850 0.01062 0.00511 0.04190 0.03180 0.01174 0.00951 0.03296 0.01004 0.02317 0.01921 0.00697 0.02405 0.07631 0.03516 0.01193 0.01356 0.00784 0.01925 0.01204 0.00245 0.03787 0.04182 0.02130 0.01884 0.02488 0.03740 0.05887 0.03560 0.01662 0.01154 0.03379 0.01169 0.01834 0.02610 0.03865 0.04647 0.05163 0.04557 0.05845 0.00422 0.01430 0.21100 0.17579 0.02471 0.01809 0.07066 0.00588 0.04082 0.04859 0.01686 0.03101 9-oxoODE 1.50290 1.53270 0.28457 0.37622 0.19362 0.37847 0.24995 0.60807 0.22192 0.77189 0.45513 0.66039 0.30828 0.34153 0.38025 0.26108 0.24162 0.19694 0.03774 0.08782 0.06209 0.09997 0.06622 0.14944 0.04842 0.30527 0.09507 0.11119 0.14016 0.22486 0.06591 0.10826 0.22536 0.08090 0.18473 0.07480 0.07324 0.08180 0.06040 0.22254 0.18457 0.25148 0.20391 0.15870 0.13678 0.20316 0.09543 0.12688 0.14686 0.21385 0.43285 0.10510 0.13356 0.19454 0.14771 0.06977 0.12556 0.25488 0.30432 0.27082 0.15684 0.17531 0.19599 0.28280 0.21682 0.15269 0.06160 0.10647 0.16939 0.12114 0.18884 0.14446 0.17053 0.14526 0.20563 0.36968 0.09351 0.10942 0.56551 1.88530 0.28842 0.21258 0.43180 0.24860 0.40636 0.35722 0.22923 0.29860 20-HETE 0.11181 0.11771 0.03995 0.05993 NA 0.03847 0.01007 0.05445 0.01309 0.12246 0.06087 0.05537 0.06829 0.02191 0.03199 0.00940 0.00214 0.16668 NA NA NA NA NA NA NA NA 0.03945 NA NA NA NA NA NA NA NA NA NA NA NA 0.01135 0.04780 0.04616 0.01175 NA 0.02862 0.01704 0.03941 0.01300 0.01455 0.11025 0.37634 0.03035 0.00496 0.05141 0.05445 0.06406 0.02800 0.09551 0.01787 0.09612 0.02976 0.09001 0.03558 0.09990 0.00429 0.03874 0.00661 NA NA 0.00302 0.01530 NA NA NA 0.00058 NA NA NA NA NA NA 0.00955 NA 0.02598 0.03832 NA NA 0.00412 19-HETE 0.00645 1.19851 0.28975 0.32653 NA 0.27064 NA 0.05736 0.06921 0.34706 0.42659 0.12304 0.16869 5.22133 0.14226 0.16999 0.05132 0.14126 0.07492 0.03365 0.01766 0.06740 0.01331 NA NA 0.09651 0.06945 0.07990 0.07953 0.10062 NA 0.05074 0.10115 0.02278 0.02108 0.11677 NA 0.01098 NA 0.09938 0.18515 0.54761 0.40171 0.07642 0.02409 0.08109 0.04800 0.07706 0.10921 0.18511 0.20753 0.31913 0.08472 0.21366 0.22936 0.03755 0.12988 0.40502 0.11841 0.74732 0.02767 0.49987 0.17926 0.18230 0.13105 0.06128 NA 0.05528 0.03549 0.05590 0.05780 0.04167 0.05207 0.08423 0.04642 0.09108 0.05542 0.06128 0.08517 0.07247 0.06447 NA 0.20779 0.12021 0.18492 0.04623 0.12057 0.11837 18-HETE NA 0.21064 0.03354 0.08486 0.00037 0.09129 0.00427 0.02299 0.02185 0.06912 0.06427 0.05104 0.05998 0.02855 0.02045 0.03510 0.02487 0.00758 NA NA NA NA NA NA NA NA NA NA NA 0.01217 NA NA NA NA NA NA NA NA 0.00662 0.01836 0.03107 0.04964 0.02362 0.01014 0.01055 0.01958 0.01678 NA 0.00947 0.03207 0.05249 0.04360 0.01067 0.01578 0.02998 0.00701 0.01062 0.03240 0.01508 0.07870 0.00934 0.03089 0.01394 0.03039 0.02008 0.02809 0.00354 0.00096 0.00083 0.00126 0.00422 0.00376 0.00043 0.00108 0.00477 0.00430 NA 0.00384 NA 0.00336 NA NA NA 0.01549 0.00884 NA 0.01573 0.00863 17-HETE NA 0.05933 0.00729 0.01960 NA 0.02179 0.00078 0.00885 0.00423 0.01187 0.01949 0.01166 0.00424 0.00447 0.00167 0.01357 0.00216 0.01002 NA NA NA NA NA NA NA NA NA NA NA 0.00282 NA NA NA NA NA NA 0.00079 NA NA 0.00139 0.00294 0.00769 0.00844 0.00386 NA 0.00838 0.00662 0.00247 0.00446 0.02470 0.01141 0.01947 0.00170 0.00566 0.00763 0.00005 NA 0.01772 NA 0.01154 0.00494 0.01293 0.00276 0.01055 0.00641 0.00665 0.00090 0.00065 NA NA NA 0.00013 0.00047 0.00250 0.00100 0.00144 0.00158 0.00032 0.01291 0.00482 NA NA 0.00358 NA 0.00482 NA 0.00226 0.00619 16-HETE 0.04615 0.04350 NA 0.02112 NA 0.04939 NA 0.01772 NA 0.02562 NA NA 0.00416 NA 0.00554 0.01480 0.00954 0.02869 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.00269 NA 0.00249 0.01044 0.00629 0.00514 0.00012 0.00692 0.00024 NA 0.02735 0.01895 0.00633 NA 0.00130 0.00394 NA NA NA 0.00786 0.00444 0.00108 0.00118 0.00462 0.00558 0.01759 0.01358 NA NA NA 0.00321 NA 0.00664 NA NA NA NA NA NA 0.04753 0.00951 0.03983 0.01232 0.01644 0.04364 0.01965 0.01631 0.03616 0.04610 5,6-EET 0.38877 0.05236 0.11512 0.14936 0.01659 0.15570 0.05675 0.03604 0.02481 0.09886 0.13149 0.18930 0.14968 0.32674 0.10995 0.07396 0.11171 0.23492 0.02772 0.05998 0.01976 0.02405 0.03200 0.04277 0.01227 0.10611 0.02650 0.03438 0.05204 0.10659 0.01933 0.02829 0.03892 0.05423 0.01189 0.02226 0.02273 0.01823 0.06292 0.13046 0.04704 0.08513 0.05808 0.06515 0.02042 0.03331 0.02369 0.01691 0.03575 0.12771 0.05842 0.04682 0.03549 0.04965 0.13668 0.00764 0.05241 0.16461 0.07636 0.06720 0.05347 0.12027 0.09674 0.15786 0.08819 0.05257 0.09211 0.21452 0.06426 0.11236 0.11618 0.35322 0.09713 0.41284 0.26667 0.16047 0.07059 0.07771 2.07727 1.16356 0.45836 0.52105 0.54273 1.50351 1.30854 0.76215 0.34714 0.64118 8,9-EET 0.05949 0.19246 0.22187 0.12807 NA 0.18500 0.01916 0.10154 0.03669 0.10867 0.11820 0.12063 0.18109 0.18950 0.17384 0.06145 0.03837 0.10193 0.01421 0.01625 0.01771 0.02698 0.01197 0.02510 0.00882 0.04977 0.02015 0.03138 0.03108 0.08972 0.02237 0.00981 NA 0.03313 NA NA NA 0.02149 0.01393 0.06764 0.02344 0.03970 0.01435 0.02752 0.01404 0.01637 NA 0.01995 0.04677 0.06680 0.03445 0.01844 0.04945 0.02533 0.04886 NA NA 0.07898 0.03835 0.01643 0.03126 0.02760 0.05055 0.11701 0.09283 0.02219 0.03294 0.10166 0.01293 0.02940 0.05686 0.01619 0.02618 0.09026 0.08830 0.10742 0.02331 0.02125 0.62492 0.45154 0.11630 0.27066 0.22794 0.22980 0.25392 0.22517 0.08132 0.14810 11,12-EET 0.20666 0.12915 0.18170 0.11368 0.06081 0.34385 0.04465 0.05223 0.04092 0.06281 0.15712 0.24605 0.22513 0.33102 0.12221 0.15930 0.07123 0.20807 0.03775 0.05421 0.02036 0.02334 0.02255 0.03843 0.01395 0.10388 0.03130 0.02376 0.04410 0.06975 0.00947 0.02032 0.02166 0.04561 0.01040 0.01710 0.01379 0.01428 0.03581 0.16917 0.04188 0.06256 0.03610 0.03925 0.01802 0.01669 0.02359 0.02850 0.02779 0.08402 0.03029 0.04080 0.02240 0.01856 0.12722 0.00807 0.04488 0.22406 0.06934 0.06330 0.04931 0.10011 0.10355 0.16318 0.10468 0.05115 0.08985 0.14079 0.03025 0.10854 0.10916 0.26357 0.09159 0.35800 0.22358 0.11807 0.03547 0.06269 0.97974 0.66245 0.19845 0.30318 0.37735 0.67719 0.64060 0.39347 0.22317 0.38579 14,15-EET 0.17161 0.22943 0.17250 0.33947 0.05089 0.42410 0.13451 0.10242 0.02193 0.16074 0.17558 0.31541 0.40813 0.44720 0.39513 0.14697 0.05179 0.20979 0.06847 0.02861 0.01634 NA 0.01583 0.06027 0.02442 0.06564 0.07559 0.02922 0.04682 0.09000 0.00769 0.02236 0.01711 0.06300 NA 0.00411 0.00709 0.01694 0.08406 0.25845 0.04332 0.12308 0.12257 0.09297 0.02830 0.04716 0.03462 0.05670 0.05343 0.20476 0.03962 0.06041 0.00655 0.03223 0.13621 NA 0.06567 0.30229 0.12961 0.10310 0.16735 0.20592 0.16056 0.31358 0.25113 0.14010 0.65849 0.28633 0.03961 0.24403 0.28231 0.62770 0.11498 1.11558 0.42731 0.31704 0.17082 0.08321 2.58074 0.87562 0.14027 0.20706 0.57212 0.53420 0.35789 0.27304 0.15916 0.43570 19,20 DiHDPA NA 1.06569 0.10583 0.43501 0.02584 0.50570 0.02906 0.08586 0.09141 0.45879 0.36806 0.14200 0.28143 0.16697 0.24840 0.14231 0.15626 0.07099 NA 0.03691 0.00907 0.00693 0.00215 0.03668 0.00008 0.01094 0.00870 0.03107 0.01416 0.06782 NA 0.00559 0.01460 0.02733 0.00731 0.01062 0.01020 0.01344 0.02896 0.03980 0.09230 0.09983 0.07975 0.04570 0.01669 0.07727 0.04693 0.02443 0.05827 0.11248 0.47457 0.15162 0.01639 0.05613 0.12255 0.02320 0.05826 0.08606 0.07231 0.21360 0.02847 0.06521 0.04637 0.07192 0.05971 0.08020 0.01256 0.00632 0.00180 0.01812 0.01430 0.01271 0.01298 0.01128 0.01168 0.01357 0.00284 0.01409 0.02809 0.02846 0.01321 0.02540 0.01968 0.06049 0.03586 0.00957 0.04836 0.05245 9,10 EpOME 0.44085 0.34748 0.20663 0.25718 0.09424 0.22658 0.12412 0.09908 0.08186 0.37574 0.28632 0.39588 0.20283 0.51338 0.26140 0.12976 0.08499 0.07623 0.02200 0.03711 0.04672 0.03156 0.00847 0.04885 0.02504 0.14318 0.04502 0.02856 0.05268 0.14543 0.00980 0.02764 0.04500 0.02451 0.02836 0.03631 0.02209 0.02884 0.02247 0.15230 0.05967 0.14656 0.07493 0.07042 0.04301 0.05977 0.02713 0.06423 0.07020 0.11083 0.05798 0.04567 0.03060 0.03986 0.08042 0.00467 0.11062 0.11339 0.15112 0.18037 0.19430 0.11191 0.14328 0.14295 0.18128 0.14673 0.04951 0.12496 0.11165 0.13952 0.16366 0.15370 0.16036 0.16039 0.21717 0.32262 0.08926 0.09150 0.75704 0.54356 0.20638 0.16641 0.95032 0.36342 0.28918 0.41990 0.11387 0.17469 12,13 EpOME 0.34982 0.49124 0.71052 0.60542 0.32780 0.71295 0.35930 0.29284 0.32508 0.57008 0.81689 0.75538 0.68901 0.99092 0.58242 0.16052 0.21117 0.21738 0.11217 0.09350 0.10940 0.10533 0.07203 0.15547 0.07414 0.38243 0.10591 0.07937 0.13221 0.34043 0.03784 0.14223 0.10550 0.11544 0.07523 0.09395 0.07184 0.04532 0.15094 0.50147 0.25938 0.42168 0.23763 0.30267 0.10379 0.16599 0.10370 0.11807 0.23320 0.46323 0.17792 0.23611 0.17359 0.16934 0.41617 0.01395 0.27193 0.49592 0.45151 0.81663 0.42040 0.56840 0.65100 0.54507 0.54320 0.30957 0.47898 0.55835 0.19672 0.29941 0.25863 0.54453 0.30238 1.14763 0.93752 0.95220 0.29127 0.23227 0.79588 0.72142 0.30330 0.35805 0.69822 0.88176 0.64288 0.54977 0.30377 0.39725 5,6-diHETrE 0.01444 1.12675 0.29784 0.69728 0.16245 1.39287 0.09468 0.21653 0.15498 0.55021 0.35535 0.46392 0.33838 0.17309 0.24742 0.39866 0.07050 0.31133 0.00561 0.08585 0.03162 0.02693 0.01651 0.09070 0.03071 0.04394 0.02878 0.05243 0.03218 0.09507 0.01932 0.01053 0.01752 0.03687 0.00815 0.00546 0.02162 0.00779 0.04724 0.04900 0.04616 0.09812 0.11960 0.05543 0.00493 0.08632 0.04914 0.01625 0.03747 0.26552 0.12790 0.07783 0.04491 0.04929 0.06193 0.00714 0.01796 0.09001 0.03349 0.06038 0.01848 0.09452 0.03865 0.08658 0.08711 0.08719 0.02886 0.03791 0.00869 0.01593 0.09011 0.05757 0.02916 0.04283 0.04238 0.09785 0.01112 0.01489 0.16441 0.05608 0.01890 0.01287 0.14840 0.02937 0.08997 0.02944 0.05262 0.15229 8,9-diHETrE 0.05388 1.36018 1.12238 1.59181 0.19202 1.65245 0.44649 0.83505 0.17880 1.06802 1.23714 0.75903 0.51523 0.32455 0.60163 0.81018 0.12027 0.28420 0.01668 0.10019 0.05624 0.05097 0.03081 0.11821 0.07895 0.09208 0.03131 0.05732 0.11201 0.15686 0.05212 0.02567 0.03907 0.17211 0.01589 0.02848 0.07902 0.02117 0.16979 0.10445 0.09626 0.26663 0.30012 0.06900 0.06516 0.15281 0.10746 0.03657 0.07760 0.28700 0.45105 0.20726 0.13680 0.17279 0.15640 0.02922 0.03634 0.32514 0.11439 0.24816 0.06314 0.38717 0.10929 0.12412 0.13589 0.11752 0.03218 0.06230 0.01729 0.01657 0.08722 0.05172 0.04390 0.01719 0.07100 0.10738 0.02726 0.01957 0.35599 0.10390 0.02083 0.02919 0.56961 0.10127 0.15195 0.05017 0.09758 0.19156 11,12-diHETrE 0.01346 1.84739 0.63897 1.87466 0.21119 2.23019 0.29970 1.17290 0.25164 1.36108 0.90318 0.90953 0.70945 0.43454 0.81423 0.73651 0.16733 0.44150 0.02390 0.14849 0.06360 0.07685 0.03539 0.20321 0.09351 0.14849 0.10522 0.06791 0.07228 0.15854 0.04268 0.03593 0.07740 0.10180 0.02219 0.03319 0.03399 0.02789 0.06747 0.13379 0.11856 0.26173 0.15304 0.18052 0.08712 0.19573 0.16578 0.03662 0.09379 0.49311 0.64944 0.17857 0.10998 0.13538 0.27242 0.03176 0.06515 0.17947 0.12842 0.16833 0.12114 0.32882 0.10923 0.21540 0.24789 0.25932 0.03551 0.02657 0.01304 0.02329 0.05935 0.05239 0.02907 0.06744 0.05461 0.05734 0.02636 0.02764 0.06045 0.03386 0.01953 0.02720 0.02104 0.06057 0.03444 0.01259 0.02891 0.05983 14,15-diHETrE 0.06451 2.31001 1.42232 3.79049 0.25878 4.04674 0.58350 2.04761 0.45106 2.43157 2.54325 1.49113 1.10423 0.78832 1.32787 1.42004 0.35251 0.81076 0.04805 0.25973 0.14183 0.14654 0.08190 0.36374 0.15136 0.31496 0.17820 0.14693 0.17723 0.22555 0.06715 0.03743 0.11652 0.29858 0.04369 0.06185 0.07750 0.05402 0.19311 0.19914 0.22524 0.42837 0.35315 0.22376 0.07779 0.37587 0.24955 0.06823 0.20010 0.75504 1.19290 0.33669 0.16950 0.28537 0.48593 0.05124 0.08173 0.38513 0.24406 0.34590 0.21409 0.63008 0.23704 0.31181 0.44748 0.48320 0.05280 0.05984 0.02738 0.04262 0.09403 0.08538 0.08764 0.11273 0.08486 0.12637 0.03605 0.05405 0.23868 0.14500 0.04678 0.10307 0.07815 0.13909 0.09248 0.06759 0.06471 0.13842 9,10 diHOME 0.09151 3.17500 0.25297 0.31194 0.12350 0.59459 0.15746 0.21245 0.89837 0.81834 0.57314 0.87730 0.35476 0.28814 0.16128 0.32027 0.50681 0.37168 0.03718 0.14763 0.09726 0.10406 0.04444 0.31525 0.07625 0.18473 0.13436 0.10244 0.18327 0.48183 0.04502 0.05821 0.19166 0.15305 0.07722 0.06325 0.08027 0.06846 0.11091 0.15435 0.25090 0.64401 0.51751 0.21267 0.06434 0.44235 0.16767 0.09632 0.13668 0.77389 1.25534 0.41526 0.16720 0.24096 0.74495 0.05285 0.21445 0.36211 0.51986 0.78445 0.17166 0.55641 0.27800 0.38109 0.47082 0.51011 0.05208 0.05693 0.06539 0.05124 0.07224 0.04599 0.09111 0.07722 0.12431 0.14421 0.04501 0.07234 0.09980 0.16029 0.06471 0.15058 0.14517 0.10469 0.10669 0.06901 0.08373 0.12900 12,13 diHOME 0.10847 1.57219 0.31072 0.38406 0.11690 0.64507 0.19451 0.27267 0.65271 0.64397 0.74000 0.67895 0.33744 0.27830 0.19566 0.24963 0.45572 0.36396 0.05092 0.14511 0.09265 0.12719 0.06384 0.31080 0.08986 0.21211 0.11553 0.10239 0.19163 0.31823 0.04356 0.05447 0.18508 0.18418 0.07207 0.07523 0.05791 0.05407 0.10798 0.15861 0.27174 0.64272 0.32778 0.24185 0.06582 0.33906 0.15926 0.07192 0.18295 0.49100 1.05620 0.40926 0.20587 0.29383 0.63898 0.04330 0.18717 0.30112 0.47566 0.92637 0.17497 0.61976 0.29152 0.29056 0.35343 0.37691 0.05501 0.06536 0.05868 0.04822 0.07396 0.05318 0.08738 0.09547 0.09619 0.12282 0.05087 0.06480 0.10584 0.14289 0.06356 0.19886 0.08041 0.13473 0.09772 0.08148 0.07250 0.10606 20cooh AA 0.02466 1.02528 1.49752 0.88529 0.32965 0.33942 0.18901 0.38643 0.25628 0.50329 0.41820 1.53349 0.80031 0.03186 0.34084 0.39828 0.16784 0.88895 NA 0.04623 0.04284 0.07247 NA 0.08105 0.00078 0.04282 0.13325 0.03174 0.01589 0.03740 0.00879 NA 0.03562 0.07925 0.02142 0.00973 0.02909 0.10985 0.05871 0.04412 0.18775 0.21490 0.12925 0.07663 0.07729 0.12659 0.08268 0.03704 0.06831 0.41713 0.47575 0.05540 0.05105 0.17283 0.29136 0.14749 0.17811 0.24008 0.11244 0.18633 0.09522 0.21882 0.06776 0.20436 0.10622 0.12905 0.06375 0.05844 0.06530 0.09133 0.17431 0.04078 0.07887 0.19238 0.09489 0.07313 0.03643 0.03400 0.11288 0.16751 0.04452 0.18138 0.12575 0.03993 0.03064 0.08605 0.08344 0.11873 FA(14:0) NA 28.31774 58.69585 284.32515 351.30767 288.83365 118.30286 57.00694 149.87643 19.29174 109.74281 37.20767 66.57174 183.33924 172.58645 117.01003 132.91161 16.08022 39.65019 29.39779 2.83668 17.91416 2.34627 NA NA 8.21609 11.88985 36.80860 15.53731 26.16572 2.73099 37.41886 20.82215 7.66504 33.21306 27.06601 NA 7.13098 10.37726 59.75545 101.37168 137.45999 70.41616 85.20022 55.04328 62.14656 33.43522 17.28288 36.14874 41.76200 69.32518 44.57907 59.84704 108.41464 66.42544 35.57535 70.65901 86.57009 132.07904 172.46670 36.35222 38.66303 67.65229 42.31411 62.50621 54.53719 10.11294 23.17478 15.29778 NA 16.06673 NA 6.61929 10.72445 9.56955 2.82857 37.03866 28.04252 6.51017 24.24040 15.10205 12.23832 22.76376 29.54864 57.85884 14.76630 23.55240 25.01292 FA(15:0) 22.17486 49.99159 17.66901 45.21252 44.85601 36.45143 26.89367 13.23845 26.09119 20.46298 17.54434 7.17211 19.09965 24.11205 27.40110 34.60795 22.85186 4.99223 1.33641 1.17209 NA 0.29403 1.32316 NA NA 2.32144 1.98922 4.10183 1.01866 3.18545 NA 2.81017 1.50882 0.61571 2.03171 0.55425 0.74643 1.43092 0.55237 11.70159 14.72849 27.84936 9.48275 10.11467 8.01982 11.03163 4.28118 0.17486 4.85268 8.61871 5.89606 10.27803 6.10058 15.50547 10.18325 3.37207 11.73429 20.85359 21.74552 27.02837 4.03137 7.55058 10.76096 11.76960 10.81968 9.33216 NA NA NA NA NA NA NA NA NA NA 2.72267 2.61286 2.90506 5.77439 2.31660 4.58097 4.87638 4.55038 6.98089 4.52396 3.05569 3.66818 FA(16:0) 2626.44218 1721.59394 1928.50702 4635.72173 3319.75875 3854.82696 2864.66989 1365.12244 2991.75124 1052.11378 1610.59974 1035.42128 2417.58826 3456.66192 2400.67256 2321.46852 2174.05939 743.57363 383.67134 529.07524 145.88042 225.57359 187.60858 104.24540 29.10274 297.21186 246.11313 480.99792 232.43441 633.82627 72.45997 711.06921 671.43484 281.30992 551.16871 446.59407 182.35587 204.06719 370.96876 1219.84098 1530.88301 2277.16651 1193.64891 1349.93440 909.03500 1063.17018 598.20972 347.35915 776.28520 1038.35772 1460.59497 1541.45285 853.91349 1429.37921 1489.84003 553.15857 1400.15697 1966.13200 2034.73341 2640.79264 611.80127 1089.19703 1422.55877 1329.37210 1498.80245 1002.69513 320.12404 361.16636 291.31795 128.55495 173.62251 43.97971 110.38841 209.05943 229.67699 102.47595 76.60819 494.94813 324.19801 568.90413 323.86908 340.75172 480.08895 546.51537 966.57671 578.65090 321.08437 369.63533 FA(16:1) 51.35781 74.20360 102.78596 311.25820 673.53897 362.69336 153.08255 97.54683 169.69344 33.89923 111.63539 45.57060 66.59012 278.14144 217.44341 212.17060 194.39457 18.41504 21.95757 21.20112 21.19012 16.58641 9.53791 9.74702 3.57475 21.52294 31.50172 30.41259 12.21411 44.79777 3.21582 29.19069 26.01075 7.48116 14.60618 24.99352 7.28133 7.75602 11.08054 65.76867 67.50976 110.06276 36.56520 76.32986 66.99195 80.82617 33.61401 16.82085 44.85144 58.21164 239.71464 39.88747 50.56292 56.81835 48.93820 9.46369 57.95387 50.76511 126.42483 226.52209 50.24521 46.28325 52.60361 24.50200 37.86472 68.66452 11.39121 17.51242 12.56207 6.32488 14.76413 3.16895 3.51454 3.06984 7.17124 6.33245 9.12762 13.72678 19.48586 21.51690 23.97716 16.80946 26.70533 57.88955 66.46040 23.14694 23.94068 41.16412 FA(17:0) 44.81265 31.22435 32.09792 72.52019 39.36781 74.92060 33.57814 19.52292 40.22075 15.89851 21.35587 12.18319 42.19550 56.95816 38.51814 55.11814 38.97993 10.51890 5.49611 5.61650 1.73010 1.58895 3.02267 0.71779 NA 3.59949 3.12956 4.49929 5.47832 6.81988 1.76526 8.98811 8.36493 4.97527 9.14004 4.91116 2.46954 2.97117 6.10872 19.93376 18.75381 42.03320 15.15480 12.88506 6.61527 12.80255 5.96574 3.69907 10.37075 16.81824 15.12096 23.93122 11.57502 23.13319 18.70140 8.91600 19.00439 32.67535 29.55242 36.47402 5.64643 15.63049 18.13741 21.29566 22.34583 9.80715 3.76780 3.85018 0.67270 NA NA NA 1.27528 1.54264 3.14596 0.40206 7.82868 4.40112 6.67590 7.53571 3.82569 6.14786 6.11960 8.77350 10.72322 7.93155 4.44318 6.22334 FA(17:1) 5.85084 7.02962 7.95866 20.33488 23.67890 20.94215 11.75282 6.27818 11.45213 2.44634 5.59460 2.79920 5.95415 18.36965 9.94599 13.68970 11.00030 1.56112 0.97195 1.42213 2.35269 0.38648 0.73910 0.50116 0.29986 1.75298 2.16517 1.55346 1.16681 2.93707 0.13732 2.14674 1.93093 0.38175 1.26248 2.14924 0.42561 0.77207 1.09391 4.58202 4.52524 10.75118 4.33529 3.64341 2.95763 4.68623 1.75992 1.11426 2.69628 4.16660 6.63934 3.48423 4.06621 4.42403 3.65106 1.01821 5.29936 4.93088 8.10891 11.23155 2.24123 4.33695 4.08337 2.25417 2.58756 3.19103 0.52637 1.19272 0.50665 0.41800 0.46087 0.09357 0.06635 NA 0.30626 0.18531 1.78247 0.66702 3.37156 2.86079 2.46284 3.54454 3.65438 3.42133 5.82930 2.94398 1.94841 3.55240 FA(18:0) 3037.30601 1230.91391 1284.22858 2481.15777 1301.92211 2574.57272 1353.05636 819.09711 1272.80204 751.89044 795.84880 599.03171 1597.20037 1662.15765 1639.07107 1636.20705 1184.28575 458.47867 219.75080 360.97402 101.57202 112.77548 106.94004 69.23941 28.31217 148.52577 111.08056 181.12033 183.82830 293.89389 121.32798 243.70718 304.71789 212.86696 228.48236 184.71730 135.73171 143.89166 217.60110 601.84755 652.96874 972.20740 584.53957 531.79404 378.19264 418.40640 288.00261 226.05268 322.16270 495.41385 816.34298 823.18214 440.08806 640.44983 716.76612 546.43273 652.31232 1278.19253 1079.56808 1190.89885 340.66620 603.32879 600.38738 789.76881 822.40269 458.48788 217.79825 73.60795 226.67639 45.59297 25.13638 NA 119.44270 80.60853 183.99005 35.03502 261.95975 134.57288 216.80800 389.23130 186.93016 282.73231 262.47848 346.93740 541.99031 395.07904 208.41545 293.07153 FA(18:1) 1045.42438 1136.90594 584.90672 897.66125 723.99795 708.82784 900.62398 546.51762 917.81811 535.48888 624.82358 527.18450 714.02082 803.08268 634.99354 634.38631 690.63752 245.94133 221.13881 221.50044 141.49891 106.00289 139.28657 120.66759 11.89850 149.85117 198.41722 226.18042 192.12925 432.89503 43.71990 375.39797 373.57969 130.36926 315.80278 274.89483 103.13388 118.10876 211.18891 663.33049 707.43929 792.65836 501.96331 561.46485 584.69273 558.52645 294.62780 254.53855 390.58652 489.14462 767.27471 670.67428 381.54311 714.46170 617.72750 260.57724 716.09265 681.58263 827.88153 831.26179 357.25207 533.57413 669.02826 442.93966 600.26703 452.67620 157.34230 269.36135 143.41344 123.45916 111.53402 64.10180 50.32355 119.16434 150.43211 147.39824 145.43334 244.76847 177.25194 308.32678 199.40313 235.34059 278.12592 284.80864 453.37007 231.16965 218.95542 277.45467 FA(18:2) 1077.95770 1620.70560 1313.95801 1927.77721 1009.73646 1284.29283 1430.36492 917.77109 1133.87847 667.76516 832.18591 799.23574 1426.72271 874.41788 1295.70259 1116.48395 1054.47286 387.52819 164.30559 260.86161 178.31876 131.43242 202.20745 193.39889 54.69767 311.62387 248.13892 256.37163 214.64546 625.82990 71.16195 278.66156 382.57407 197.71100 260.51723 295.53591 159.58201 162.21991 360.15675 677.82223 909.46747 1060.81360 729.51502 846.28305 396.06048 881.04825 508.41296 294.53963 627.30539 957.90594 573.28632 1105.82187 568.08668 744.35156 779.50011 288.45405 743.06829 1230.37029 1087.68752 1248.64525 584.60452 953.62610 1070.49500 1156.82035 1151.99626 1081.28673 291.87984 407.71750 200.10459 349.16165 190.61300 170.13544 160.58051 225.78724 487.20725 248.14534 334.82904 458.71838 355.00223 566.37375 273.52229 446.32923 480.37827 363.88444 752.59904 745.96695 365.54808 378.87742 FA(18:3 N3) 13.39730 4.50676 10.31172 21.65635 11.25043 12.28889 7.77944 15.28607 4.69543 2.80589 9.12887 3.19611 16.07846 11.19372 15.43348 17.58720 10.13349 2.94917 6.48076 2.80184 0.81039 1.20639 1.43119 0.68310 2.29564 5.55483 2.23931 0.80344 1.08441 3.45237 0.77261 2.60325 2.14986 2.35922 2.36215 2.48193 0.87663 0.66469 3.92642 9.06765 5.35079 11.04682 5.14619 5.15730 3.47869 3.98871 5.91161 1.47282 3.33083 8.67786 1.51868 5.16453 10.56205 4.09039 6.55588 3.26914 5.31132 10.40620 5.87663 7.58151 3.87794 8.58847 5.75986 5.02893 6.20479 3.87074 1.75657 2.54215 0.89054 1.59129 1.45671 1.11403 1.11438 0.40509 1.35811 1.53892 2.92901 3.63900 4.24617 7.77560 3.49691 4.11831 4.36414 7.64578 10.11914 5.59881 3.41716 12.17900 FA(18:3 N6) 66.54680 90.40659 69.16188 135.91778 71.76752 84.92744 80.07608 47.24122 82.99522 45.59441 61.91987 35.24506 83.37746 48.63169 79.60462 69.11839 67.84860 18.30936 11.16555 15.87350 11.11019 10.15215 11.03765 10.30870 2.28317 16.87621 12.50097 18.64778 12.52201 38.78035 5.26654 19.01073 23.57924 11.77704 23.10953 20.32786 7.04654 10.67096 20.04210 31.40764 55.68769 60.78112 45.72493 52.34407 19.56447 59.23503 23.82376 25.59443 35.15708 44.05643 49.05122 63.76668 34.54751 39.65433 40.19600 18.27721 44.94931 79.34590 65.67960 93.18145 41.82634 47.32455 80.88405 60.49148 51.55804 71.90657 18.19550 26.36610 11.64852 19.36462 15.22470 7.23270 8.35956 11.22961 28.22900 16.77628 19.34007 42.03219 19.78848 41.73782 22.40368 28.12917 38.42416 31.69268 57.09391 32.28035 24.51766 25.98707 FA(18:4) NA NA 2.92996 4.49872 2.18861 3.12965 2.55979 1.46318 2.51431 NA 1.71779 1.34936 2.83237 1.85405 2.77953 2.17255 2.63205 0.15065 0.84002 0.23191 0.00655 0.03797 0.00266 NA 0.01911 0.27255 NA NA NA 0.12476 NA 0.21758 0.11190 0.09904 0.20983 0.19709 NA NA 0.20975 0.41288 0.34409 0.72811 0.28721 0.28087 0.06203 0.20698 0.21147 0.04269 0.11000 0.13870 0.09217 0.29424 0.83792 0.18470 0.33029 0.14896 0.26891 0.57593 0.33068 0.58729 0.36033 0.54064 0.25845 0.13962 0.13654 0.12468 NA 0.22623 NA NA NA NA NA NA NA NA 1.01060 0.47267 0.45819 1.00674 0.59119 0.56233 0.59805 0.84358 1.31074 0.50835 0.48602 1.75537 FA(20:0) 20.70215 5.24412 3.75366 11.27799 7.64500 16.18190 5.77239 3.81904 5.87723 3.96298 3.03906 2.23527 5.67752 8.02546 8.53532 6.24728 4.90340 1.02632 0.41981 0.95019 1.23341 0.01575 0.08371 NA NA NA 0.32078 0.25867 0.84273 0.84119 0.61738 0.60167 0.40878 0.62692 0.80465 0.30490 0.15637 0.42108 0.48072 1.56306 1.98501 3.48850 1.97683 0.73276 0.98130 0.61173 0.41497 0.79565 0.80917 0.82604 3.06548 2.36115 1.17384 1.91219 1.86988 2.07642 3.83892 6.29505 4.10085 5.17603 1.03711 1.07676 2.13782 1.85483 2.63523 0.24439 0.56984 0.35381 0.66801 NA 0.00161 NA 0.68478 0.32727 0.48689 NA 2.57389 0.40756 1.13564 3.47525 0.89811 1.68149 1.13159 2.40310 2.41571 1.39410 1.04150 1.53582 FA(20:1) 1.19193 2.57745 2.45609 13.95663 11.00082 12.20970 8.82250 4.12212 5.99762 0.82088 2.15801 2.44975 4.86941 10.78803 10.83180 5.32316 4.64474 NA NA NA 0.26531 NA NA NA NA NA 0.99436 NA NA 0.23539 NA NA 0.06421 NA NA 0.25166 NA NA NA 0.20228 0.80773 2.11868 0.87249 0.99100 1.25484 1.09243 NA NA NA 0.82959 0.95586 0.96465 0.39772 1.16174 0.25528 NA 0.73739 1.68380 1.64859 3.23983 0.55755 0.67147 0.50810 0.26625 0.76245 0.86306 NA 0.16612 NA NA NA NA NA NA 0.05307 NA 0.59891 0.03793 0.48321 2.27897 0.85323 0.77649 1.27920 2.00290 2.89375 1.34613 0.93926 1.22565 FA(20:2) 10.26539 9.11776 17.13605 70.37856 48.19660 61.90519 35.31791 21.22614 23.57389 5.37593 10.01766 13.40175 24.22219 26.72855 45.96074 22.92855 19.72934 4.09234 2.57461 2.65633 2.06871 1.60715 2.33271 2.62677 0.93101 3.27101 3.51628 3.17391 2.82097 6.42620 1.62184 2.79093 3.48687 3.04463 3.03687 2.78481 1.53320 1.93376 3.34715 7.07954 9.61601 14.07794 9.25331 15.05577 11.00311 14.31655 6.46998 5.14765 5.66309 10.25624 7.88918 12.91324 6.99183 12.30737 8.01292 4.57230 8.75097 15.85669 13.81857 17.79157 8.18934 9.49491 10.82653 10.13269 12.53057 19.93867 3.87302 4.73141 4.00745 4.90169 4.14123 2.44521 2.46809 4.40878 10.15486 4.58050 16.82952 4.62823 NA NA NA NA NA NA 1.99843 1.72007 NA NA FA(20:3 N3) NA NA 1.26598 8.10118 14.30586 7.06958 3.80381 7.53049 1.09443 1.07184 1.89110 1.56821 2.78159 7.31046 11.15949 3.61052 1.67446 0.19061 0.17523 0.07572 NA NA 6.90077 0.01573 NA 0.00110 1.40795 0.03091 0.11043 1.11836 0.15043 0.18197 0.06187 0.10574 0.05971 0.07795 0.12801 0.12559 0.12851 1.48809 0.67919 1.57401 0.79942 0.95390 0.44990 0.98776 1.19833 0.04204 0.26888 1.86746 1.19922 0.60823 1.94245 0.66262 0.35894 0.24411 1.18090 2.04023 1.48953 1.88515 1.04811 0.95134 0.74377 0.57069 3.63734 0.71707 NA 0.38371 0.01284 0.50682 0.24028 0.00790 0.10695 NA 0.06598 NA 2.60835 NA 0.09213 0.00439 NA NA NA 1.95607 0.01890 0.18030 0.04370 1.66915 FA(20:3 N6) 34.21027 35.61904 135.16712 219.22148 126.06806 297.07448 122.75980 71.13012 88.74643 11.77269 61.40733 51.10694 116.16025 138.07173 216.06915 127.52643 81.10342 15.60594 9.19730 6.81474 4.77263 2.51945 7.52767 21.55820 2.14728 8.67361 15.73860 8.50983 5.07286 27.47863 3.07622 9.46618 6.38951 15.78016 6.32030 6.00018 4.08550 2.66120 11.49778 38.91509 37.08590 57.22027 40.84538 70.13321 17.90117 40.88042 30.04079 13.17720 23.82902 54.25567 23.10183 50.57528 38.40752 50.52915 38.11631 10.73448 33.73705 76.30200 63.78882 69.78556 28.60402 66.25280 33.88571 45.75239 52.20936 55.07738 11.68551 4.36357 1.57986 1.73796 0.72078 4.35845 4.32297 9.38704 16.46853 10.29554 17.49804 11.10957 10.73701 10.74985 6.85668 8.52349 11.94311 28.48153 22.64545 21.24187 8.28693 14.63866 FA(20:3 N9) 1.27393 0.45523 1.51244 8.03095 5.21052 8.49329 3.09619 1.80368 2.58234 0.51819 1.36660 0.94713 2.55847 2.61838 3.58792 2.89403 2.12523 0.27658 0.23243 0.13084 0.22366 0.14036 0.13773 0.20696 0.05979 0.17169 0.21704 0.30419 0.19845 0.87374 0.04450 0.19382 0.25073 0.15934 0.21204 0.22576 0.06204 0.13660 0.13169 0.56040 0.86248 1.58089 1.08964 1.71119 8.19248 1.50835 0.38913 0.63179 0.43450 0.82054 0.99024 1.48105 0.62349 2.05084 0.81939 0.32733 1.69933 1.68773 1.78965 2.01554 0.94934 1.30842 0.98374 0.87007 2.25079 2.39090 NA NA NA NA NA NA NA NA NA NA 3.34179 NA 0.11814 0.39800 0.14005 0.22955 0.35884 0.33239 0.51214 0.31056 0.19638 0.23701 FA(20:4) 240.79334 226.46632 583.99415 1465.44180 455.96250 1227.19869 500.65853 495.17985 310.76665 85.65256 255.75694 250.99867 936.01283 489.16411 929.73472 1025.36702 387.14697 140.21569 34.71177 39.06649 20.93072 11.63364 29.76961 14.29455 7.30009 44.60756 45.03466 28.05527 26.49104 77.01717 19.51984 26.37579 36.69185 38.54167 12.59267 21.14426 27.74149 19.89474 66.40139 284.56223 235.01023 396.27444 188.67591 232.53041 113.96899 166.28481 146.80880 79.80279 126.64455 308.49148 151.34883 332.25002 125.80731 212.74354 270.16375 80.05922 155.47097 604.03646 308.25581 315.40370 127.87267 277.81105 236.74576 407.11171 339.95055 216.64765 43.87678 27.80105 18.06065 55.08117 27.00616 53.31443 22.95748 59.89882 73.83908 30.44764 67.48782 50.78864 101.37374 71.29050 32.66187 48.92878 49.58567 57.74628 149.61950 129.12778 32.58387 63.89349 FA(20:5) 9.07191 6.64206 33.85166 55.00241 26.22846 58.44312 23.66267 21.46890 11.34368 2.86688 18.72392 9.26979 56.89632 22.24897 67.07027 47.73313 21.07281 7.70589 4.11748 2.69566 1.38894 0.76556 1.80653 0.60233 0.22839 2.96528 3.11362 1.85506 1.69249 5.87421 1.04661 2.21583 1.72422 3.45039 1.15576 1.33017 1.20014 1.28582 5.04267 14.51122 16.01748 17.66289 12.97641 13.09356 3.73696 8.55338 7.62211 4.63004 7.89787 22.13133 20.36375 20.78424 11.35951 9.73992 14.49908 6.20433 8.45892 34.62353 14.86553 18.94124 8.30830 11.53522 12.04555 21.20761 22.60471 11.83838 2.95069 3.00435 0.58388 2.59338 2.28364 1.89591 1.14474 3.64302 3.98535 2.17442 5.62520 8.15101 5.88526 4.47078 2.19609 3.11377 3.46994 7.22201 12.69679 7.02680 2.31345 6.42116 FA(22:0) 13.51070 8.36848 10.91064 28.33047 16.64569 74.32642 12.62185 5.81366 15.45112 5.13146 6.96716 2.93574 19.92421 23.70471 10.39712 13.70053 13.35341 1.99668 1.83111 2.01289 1.30387 0.88553 1.96872 0.01966 NA 0.09165 0.94049 3.96576 2.15845 3.43836 2.00220 3.57449 1.93245 4.02558 3.48217 2.37462 2.08865 2.39262 3.05516 6.02136 8.43022 14.46720 9.48019 4.27401 0.66498 1.71953 0.88362 4.63784 5.48222 1.74024 5.22781 6.84900 3.17345 6.59739 4.27172 3.34904 15.50452 12.91655 13.92044 12.87052 0.88553 3.79490 7.19847 7.56715 12.12569 1.12555 0.93480 2.03143 1.04220 0.87497 0.98388 0.28818 1.65825 2.01300 3.54238 2.70652 4.04539 3.49877 1.92010 7.18825 1.53228 3.52385 3.23836 6.66738 4.73337 4.03722 3.05098 2.99651 FA(22:1) 16.08304 2.57020 7.92637 21.63232 54.71078 41.37502 33.88970 19.23915 11.90005 0.62140 12.59469 11.46423 11.02085 15.48576 26.08521 14.48001 10.14539 2.06793 4.49234 13.80960 2.62674 1.64997 2.60975 1.97647 1.06620 0.47646 6.90790 1.65500 1.69547 2.53288 1.89130 3.56757 3.07656 2.27900 4.14995 2.72534 1.01693 4.21533 1.81684 1.96911 2.33645 2.19646 3.47762 1.16825 4.04399 3.02189 1.92402 0.41559 0.52455 1.42146 2.19573 1.64504 0.89906 3.23403 1.70502 2.25368 1.65583 2.23215 3.18917 2.64963 2.14694 1.07436 2.74663 2.35894 5.16837 3.20604 8.71611 19.63515 10.04046 NA 7.94036 NA NA NA NA NA 9.23514 NA 2.78109 1.54942 0.39815 1.01809 2.88676 3.16141 6.38928 5.30224 3.06490 2.33484 FA(22:2) NA NA 0.48476 4.04879 5.72570 5.20691 3.36631 2.61004 1.02554 NA 0.64390 1.14884 0.85836 1.23437 4.18855 0.77855 0.76512 0.18910 0.11541 0.45085 0.09774 NA 0.00630 0.10308 NA NA 0.48779 0.03783 0.02575 0.12569 NA 0.05810 0.16605 0.03806 0.17096 0.00816 NA 0.10742 NA 0.38897 0.32790 0.46817 0.27285 0.53724 1.24686 0.80951 0.19931 0.07213 0.28995 0.36505 0.39447 0.45570 0.02964 0.54410 0.31909 0.09817 0.32714 0.66403 0.62888 0.92031 0.48291 0.16474 0.70495 0.41580 1.22123 0.99032 NA 0.48534 1.62645 NA NA NA NA NA NA NA NA NA 0.26400 0.23780 0.21871 0.15172 0.34832 0.38769 0.52778 0.44561 0.32051 0.25507 FA(22:3) NA NA NA NA 0.06071 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 0.54881 NA NA 0.39620 NA NA NA NA NA NA NA NA 0.69269 NA 0.04318 0.03156 0.01479 0.01748 0.06840 0.07711 0.09343 0.05488 0.02879 0.04036 FA(22:4) 16.26060 9.41411 26.97450 93.34664 42.31041 95.06574 36.34680 39.69604 21.34951 6.80123 15.43978 16.74061 27.11703 33.21454 62.42064 39.00569 23.25658 8.20723 5.56704 4.38549 2.53038 2.11759 4.58730 3.46512 1.68284 4.89510 5.77681 3.94504 4.18904 8.88014 1.95917 4.02429 3.37163 3.12983 2.32897 3.04554 1.40392 1.69129 3.97499 16.50374 15.41455 21.87411 8.46916 13.30021 12.71320 13.64456 11.52600 3.93880 7.97783 18.45795 9.66897 10.39180 9.96576 14.39792 14.37268 3.85040 13.24017 20.97341 16.03351 19.33316 10.95165 19.66681 16.84724 12.83520 20.18275 13.44717 2.76059 3.83544 3.60297 4.21863 5.17268 3.78604 1.86317 3.79113 5.99150 3.67700 10.86732 3.04755 3.78888 4.22578 3.35298 3.34072 3.41032 5.47133 12.60984 6.71519 3.80075 5.29423 FA(22:5 N3) 18.43788 18.78766 34.41620 114.84766 37.20665 170.62181 45.90066 28.71629 31.71259 5.64752 18.45473 18.43487 57.88078 49.59028 67.00773 54.11452 27.18456 9.85632 3.56683 4.67184 1.32224 1.09829 3.96219 2.17797 1.06488 4.18043 4.52558 4.98881 2.25153 12.88552 1.81700 2.24206 2.71559 5.94582 2.22390 1.87290 1.93482 0.97703 3.51286 17.16837 14.76649 27.25530 14.15229 23.42020 7.56540 18.21666 9.84207 4.72980 8.23350 19.39478 15.60267 19.50042 9.26347 15.23310 16.34595 5.52835 15.28463 37.59839 27.80556 20.69594 7.42739 23.63957 20.49160 25.68596 25.78788 19.18079 4.10649 3.93913 2.58398 8.16393 6.34743 4.06677 2.19642 4.08342 9.34979 3.27393 9.55758 4.33074 6.68666 5.40384 2.45431 4.38681 6.47504 6.52122 9.78089 6.81136 3.54776 6.48344 FA(22:5 N6) 23.62568 14.22005 55.42007 106.42758 45.17986 121.59089 47.28197 39.52958 28.25098 8.85864 28.77204 23.48668 58.13984 35.82229 87.18579 75.08597 39.71683 12.61222 5.66470 5.15647 2.19500 1.79313 5.72954 2.70641 1.08160 6.35559 5.73676 3.49634 4.68837 11.06475 2.23751 5.55680 5.33964 3.43237 2.23479 4.26498 1.63066 2.67912 6.92504 26.25556 27.88863 34.33845 14.88363 16.03593 6.98989 20.01131 13.31275 6.01058 11.58696 34.95109 28.03576 22.88120 15.21674 18.88355 24.88350 6.24150 17.12383 34.91677 24.23342 31.32386 14.75512 37.86259 24.09279 24.87208 38.17385 20.71442 3.39088 5.50765 2.63225 4.68619 6.24056 3.10801 2.57039 3.85937 8.24222 4.43181 8.56622 6.50506 4.87689 6.54855 3.59733 5.31885 4.13207 8.53323 17.22683 7.62092 4.26680 7.41583 FA(22:6) 133.52165 154.21315 189.87604 800.12511 155.51938 828.52306 190.47058 88.07030 145.17632 32.55862 106.63382 86.91526 593.06463 241.71324 597.71742 424.30180 168.65766 59.32461 13.66311 25.56481 9.55710 6.14906 18.97388 11.86916 2.79553 15.54303 14.04667 24.38571 13.39740 48.32060 11.31257 16.48950 20.07764 22.40846 16.99979 11.59814 11.55241 9.77518 28.16009 99.43480 92.45508 155.28069 123.46184 104.31748 17.60535 83.89195 49.90350 28.29412 57.62244 102.41974 202.57653 219.26565 30.94834 90.24756 130.91205 64.48057 70.39629 326.19534 148.94744 150.90811 40.02205 88.62307 100.11249 217.38698 207.20553 97.93550 17.66114 19.26515 7.58307 42.04388 16.31444 18.65115 15.30292 24.25026 47.51320 17.70436 42.28777 48.45392 43.52125 34.35795 12.85155 20.11330 37.37519 18.21306 51.28189 46.90446 13.91857 28.27952 FA(23:0) 1.11513 1.24801 1.72762 4.42469 2.37605 14.08329 2.18281 0.57311 2.26673 0.65092 1.30462 0.21787 3.40496 4.89352 1.20095 2.96730 2.43259 0.25241 0.26639 0.25264 0.08097 0.16995 0.32603 0.02315 0.13390 0.03404 0.16116 0.37161 0.23810 0.46791 0.27371 0.44954 0.27700 0.41658 0.42315 0.34292 0.20090 0.36933 0.42617 0.66452 0.93277 1.48089 1.19302 0.54623 0.05987 0.21263 0.12165 0.65407 0.69858 0.19811 0.32070 0.66395 0.42989 0.72815 0.50721 0.34836 1.92530 1.21147 1.32396 1.17859 0.16098 0.42216 0.88870 0.84075 1.51792 0.10850 0.21068 0.39572 0.00863 0.05233 0.09683 0.00295 0.22036 0.22091 0.55133 0.37231 1.00425 0.52765 0.29644 0.74638 0.20284 0.45781 0.39942 0.89619 0.71321 0.75345 0.40016 0.32434 FA(24:0) 5.07461 3.84268 4.57961 15.41382 7.04547 36.49449 5.76267 2.01039 6.47676 2.03836 3.25269 0.98743 11.01058 12.30322 3.97128 6.56974 5.71792 1.53785 0.81728 1.20494 0.16898 1.26630 1.16678 0.18187 0.19224 0.33136 0.61082 1.87020 0.95924 1.94733 1.14509 1.54372 0.94359 1.88403 1.48510 1.17153 1.20271 1.35185 1.48073 1.94162 3.08774 4.36986 4.76605 2.04601 0.48239 0.80815 0.79027 1.88192 1.83363 0.46778 1.61400 3.05017 1.38998 3.02392 1.59262 1.09614 5.61845 5.14574 4.54308 4.03133 0.57104 1.49371 2.61156 2.67441 2.75161 0.63690 0.87877 1.35389 0.28942 NA 0.37625 NA 1.31811 1.18517 2.76117 0.94744 3.56693 1.76966 1.03885 3.72195 0.70787 1.64301 1.73274 3.19549 2.63647 2.39524 1.52957 1.33621 FA(24:1) 1.00384 1.68122 1.30378 6.53293 5.49380 9.70436 3.88213 1.25378 1.49047 0.88305 0.89240 0.81267 2.57118 3.64136 3.88075 2.20500 1.53067 0.19895 0.19291 0.24848 0.27880 0.16172 0.20052 0.13795 0.28327 0.20162 0.67884 0.33149 0.41239 0.45297 0.26297 0.25966 0.28234 0.36826 0.34137 0.36161 0.17462 0.40884 0.26128 0.48126 0.46526 0.93059 0.98626 0.41597 0.26911 0.36800 0.16496 0.45037 0.52071 0.31008 0.67901 0.40792 0.43109 0.47252 0.27112 0.24204 0.93385 0.64488 0.86256 0.95598 0.28404 0.38641 0.43588 0.59802 0.61859 0.53794 0.17258 0.35615 0.32303 0.31875 0.23616 0.16574 0.14106 0.33904 0.49539 0.37592 0.84755 0.40189 0.38440 0.89682 0.38265 0.57363 0.68813 1.29188 0.96147 0.85722 0.65056 0.55596 FA(26:0) 0.78551 0.42714 0.26052 1.12457 0.49896 0.92172 1.01288 0.02938 0.70022 0.15712 NA NA 0.26415 0.54614 0.48168 0.60494 0.27910 0.08655 NA NA NA 0.03295 NA NA NA NA 0.29393 0.02007 NA NA 0.12784 NA NA 0.00100 NA NA 0.23412 NA NA NA NA NA 0.23462 NA 0.15939 NA 0.29577 NA NA NA NA 0.01481 NA 0.09134 0.03730 0.08599 0.47290 0.83021 0.55151 0.36899 0.11865 NA NA NA NA NA NA 0.93431 NA NA NA NA 0.00903 NA 0.67504 NA 66.98415 NA 0.56839 0.61693 0.24629 0.31272 0.32372 0.52383 0.44060 0.47352 0.21904 0.43110 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name 6k PGF1a TxB2 PGE2 PGD2 PGF1a 6k PGE1 6,15 dk-,dh- PGF1a 15k PGF2a 15k PGE2 dhk PGF2a dhk PGE2 dhk PGD2 tetranor 12-HETE 11b PGE2 12-HHTrE 11-HETE 11-HEPE 13 HDoHE PGA2 PGJ2 15d PGD2 5-iso PGF2a VI 8-iso PGF2a III 9-HETE 9-HEPE 16 HDoHE 20 HDoHE LTE4 5-HETE 4 HDoHE 9-HOTrE 15-HETE 15-HEPE 13-HODE 15-HETrE 8-HETE 10 HDoHE 12-HETE 12-HEPE 14 HDoHE 11 HDoHE 9-HODE HXB3 5-oxoETE 15-oxoETE 9-oxoODE 20-HETE 19-HETE 18-HETE 17-HETE 16-HETE 5,6-EET 8,9-EET 11,12-EET 14,15-EET 19,20 DiHDPA 9,10 EpOME 12,13 EpOME 5,6-diHETrE 8,9-diHETrE 11,12-diHETrE 14,15-diHETrE 9,10 diHOME 12,13 diHOME 20cooh AA FA(14:0) FA(15:0) FA(16:0) FA(16:1) FA(17:0) FA(17:1) FA(18:0) FA(18:1) FA(18:2) FA(18:3 N3) FA(18:3 N6) FA(18:4) FA(20:0) FA(20:1) FA(20:2) FA(20:3 N3) FA(20:3 N6) FA(20:3 N9) FA(20:4) FA(20:5) FA(22:0) FA(22:1) FA(22:2) FA(22:3) FA(22:4) FA(22:5 N3) FA(22:5 N6) FA(22:6) FA(23:0) FA(24:0) FA(24:1) FA(26:0) METABOLITES_END #END