#METABOLOMICS WORKBENCH efahy_20180114_125103 DATATRACK_ID:1298 STUDY_ID:ST000916 ANALYSIS_ID:AN001491 PROJECT_ID:PR000633
VERSION             	1
CREATED_ON             	January 14, 2018, 12:52 pm
#PROJECT
PR:PROJECT_TITLE                 	Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
PR:PROJECT_TYPE                  	Lipidomics Study
PR:PROJECT_SUMMARY               	The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis,
PR:PROJECT_SUMMARY               	nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely
PR:PROJECT_SUMMARY               	diagnosis of these different stages, particularly NASH, is important for both
PR:PROJECT_SUMMARY               	potential reversibility and limitation of complications. Liver biopsy remains
PR:PROJECT_SUMMARY               	the clinical standard for definitive diagnosis. Diagnostic tools minimizing the
PR:PROJECT_SUMMARY               	need for invasive procedures or that add information to histologic data are
PR:PROJECT_SUMMARY               	important in novel management strategies for the growing epidemic of NAFLD. We
PR:PROJECT_SUMMARY               	describe an 'omics' approach to detecting a reproducible signature of lipid
PR:PROJECT_SUMMARY               	metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a
PR:PROJECT_SUMMARY               	double-blinded study of patients with different stages of NAFLD that involves
PR:PROJECT_SUMMARY               	profiling liver biopsies, plasma, and urine samples. Using linear discriminant
PR:PROJECT_SUMMARY               	analysis, a panel of 20 plasma metabolites that includes glycerophospholipids,
PR:PROJECT_SUMMARY               	sphingolipids, sterols, and various aqueous small molecular weight components
PR:PROJECT_SUMMARY               	involved in cellular metabolic pathways, can be used to differentiate between
PR:PROJECT_SUMMARY               	NASH and steatosis. This identification of differential biomolecular signatures
PR:PROJECT_SUMMARY               	has the potential to improve clinical diagnosis and facilitate therapeutic
PR:PROJECT_SUMMARY               	intervention of NAFLD.
PR:INSTITUTE                     	University of California, San Diego
PR:DEPARTMENT                    	Bioengineering
PR:LAST_NAME                     	Fahy
PR:FIRST_NAME                    	Eoin
PR:ADDRESS                       	9500 Gilman, La Jolla, CA, 92093, USA
PR:EMAIL                         	efahy@ucsd.edu
PR:PHONE                         	858-534-4076
PR:FUNDING_SOURCE                	NIGMS Grant GM U54069338
PR:PUBLICATIONS                  	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
PR:CONTRIBUTORS                  	LIPID MAPS Consortium
#STUDY
ST:STUDY_TITLE                   	Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part
ST:STUDY_TITLE                   	1:Plasma
ST:STUDY_TYPE                    	Lipidomics Study
ST:STUDY_SUMMARY                 	The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis,
ST:STUDY_SUMMARY                 	nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely
ST:STUDY_SUMMARY                 	diagnosis of these different stages, particularly NASH, is important for both
ST:STUDY_SUMMARY                 	potential reversibility and limitation of complications. Liver biopsy remains
ST:STUDY_SUMMARY                 	the clinical standard for definitive diagnosis. Diagnostic tools minimizing the
ST:STUDY_SUMMARY                 	need for invasive procedures or that add information to histologic data are
ST:STUDY_SUMMARY                 	important in novel management strategies for the growing epidemic of NAFLD. We
ST:STUDY_SUMMARY                 	describe an 'omics' approach to detecting a reproducible signature of lipid
ST:STUDY_SUMMARY                 	metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a
ST:STUDY_SUMMARY                 	double-blinded study of patients with different stages of NAFLD that involves
ST:STUDY_SUMMARY                 	profiling liver biopsies, plasma, and urine samples. Using linear discriminant
ST:STUDY_SUMMARY                 	analysis, a panel of 20 plasma metabolites that includes glycerophospholipids,
ST:STUDY_SUMMARY                 	sphingolipids, sterols, and various aqueous small molecular weight components
ST:STUDY_SUMMARY                 	involved in cellular metabolic pathways, can be used to differentiate between
ST:STUDY_SUMMARY                 	NASH and steatosis. This identification of differential biomolecular signatures
ST:STUDY_SUMMARY                 	has the potential to improve clinical diagnosis and facilitate therapeutic
ST:STUDY_SUMMARY                 	intervention of NAFLD.
ST:INSTITUTE                     	University of California, San Diego
ST:DEPARTMENT                    	Bioengineering
ST:LAST_NAME                     	Fahy
ST:FIRST_NAME                    	Eoin
ST:ADDRESS                       	9500 Gilman, La Jolla, CA, 92093, USA
ST:EMAIL                         	efahy@ucsd.edu
ST:PHONE                         	858-534-4076
ST:PUBLICATIONS                  	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
#SUBJECT
SU:SUBJECT_TYPE                  	Human clinical study
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:AGE_OR_AGE_RANGE              	23-83
SU:GENDER                        	Male and Female
SU:HUMAN_ETHNICITY               	Black/White
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	-	NASH005	Diagnosis:Cirrhosis	GENDER=M; BMI=31; ETHNICITY=White; AGE=45; AST=55; ALT=20; ALKP=171; TBIL=8.2; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH007	Diagnosis:Cirrhosis	GENDER=F; BMI=40.3; ETHNICITY=White; AGE=64; AST=39; ALT=20; ALKP=102; TBIL=3; GLUCOSE=92
SUBJECT_SAMPLE_FACTORS           	-	NASH009	Diagnosis:Cirrhosis	GENDER=M; BMI=40; ETHNICITY=White; AGE=49; AST=162; ALT=66; ALKP=123; TBIL=10.5; GLUCOSE=119
SUBJECT_SAMPLE_FACTORS           	-	NASH013	Diagnosis:Cirrhosis	GENDER=M; BMI=35; ETHNICITY=White; AGE=59; AST=44; ALT=32; ALKP=95; TBIL=2.9; GLUCOSE=100
SUBJECT_SAMPLE_FACTORS           	-	NASH016	Diagnosis:Cirrhosis	GENDER=M; BMI=26; ETHNICITY=Asian; AGE=66; AST=223; ALT=100; ALKP=149; TBIL=5.2; GLUCOSE=117
SUBJECT_SAMPLE_FACTORS           	-	NASH022	Diagnosis:Cirrhosis	GENDER=M; BMI=27; ETHNICITY=White; AGE=63; AST=55; ALT=34; ALKP=91; TBIL=6.5; GLUCOSE=220
SUBJECT_SAMPLE_FACTORS           	-	NASH026	Diagnosis:Cirrhosis	GENDER=M; BMI=26.5; ETHNICITY=White; AGE=57; AST=18; ALT=38; ALKP=37; TBIL=4.2; GLUCOSE=122
SUBJECT_SAMPLE_FACTORS           	-	NASH027	Diagnosis:Cirrhosis	GENDER=M; BMI=31; ETHNICITY=-; AGE=58; AST=30; ALT=36; ALKP=105; TBIL=3.4; GLUCOSE=131
SUBJECT_SAMPLE_FACTORS           	-	NASH028	Diagnosis:Cirrhosis	GENDER=F; BMI=31; ETHNICITY=White; AGE=48; AST=46; ALT=47; ALKP=192; TBIL=2.4; GLUCOSE=173
SUBJECT_SAMPLE_FACTORS           	-	NASH029	Diagnosis:Cirrhosis	GENDER=F; BMI=21.5; ETHNICITY=White; AGE=49; AST=92; ALT=54; ALKP=277; TBIL=41.7; GLUCOSE=113
SUBJECT_SAMPLE_FACTORS           	-	NASH040	Diagnosis:Cirrhosis	GENDER=F; BMI=44; ETHNICITY=White; AGE=63; AST=36; ALT=26; ALKP=62; TBIL=1.7; GLUCOSE=65
SUBJECT_SAMPLE_FACTORS           	-	NASH047	Diagnosis:Cirrhosis	GENDER=M; BMI=-; ETHNICITY=White; AGE=60; AST=51; ALT=24; ALKP=57; TBIL=11.3; GLUCOSE=241
SUBJECT_SAMPLE_FACTORS           	-	NASH048	Diagnosis:Cirrhosis	GENDER=M; BMI=26; ETHNICITY=White; AGE=66; AST=44; ALT=23; ALKP=100; TBIL=4.5; GLUCOSE=79
SUBJECT_SAMPLE_FACTORS           	-	NASH049	Diagnosis:Cirrhosis	GENDER=M; BMI=35; ETHNICITY=White; AGE=71; AST=42; ALT=21; ALKP=82; TBIL=3.8; GLUCOSE=145
SUBJECT_SAMPLE_FACTORS           	-	NASH052	Diagnosis:Cirrhosis	GENDER=M; BMI=-; ETHNICITY=-; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH055	Diagnosis:Cirrhosis	GENDER=M; BMI=36.8; ETHNICITY=White; AGE=67; AST=35; ALT=24; ALKP=91; TBIL=0.9; GLUCOSE=135
SUBJECT_SAMPLE_FACTORS           	-	NASH064	Diagnosis:Cirrhosis	GENDER=F; BMI=27.9; ETHNICITY=White; AGE=67; AST=67; ALT=31; ALKP=113; TBIL=5.5; GLUCOSE=82
SUBJECT_SAMPLE_FACTORS           	-	NASH065	Diagnosis:Cirrhosis	GENDER=M; BMI=41.9; ETHNICITY=White; AGE=36; AST=32; ALT=17; ALKP=44; TBIL=0.2; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH068	Diagnosis:Cirrhosis	GENDER=M; BMI=23; ETHNICITY=White; AGE=55; AST=46; ALT=21; ALKP=67; TBIL=1.4; GLUCOSE=96
SUBJECT_SAMPLE_FACTORS           	-	NASH069	Diagnosis:Cirrhosis	GENDER=M; BMI=29.9; ETHNICITY=White; AGE=56; AST=74; ALT=57; ALKP=258; TBIL=3.1; GLUCOSE=84
SUBJECT_SAMPLE_FACTORS           	-	NASH010	Diagnosis:NASH	GENDER=F; BMI=43.3; ETHNICITY=White; AGE=46; AST=33; ALT=35; ALKP=71; TBIL=0.4; GLUCOSE=175
SUBJECT_SAMPLE_FACTORS           	-	NASH012	Diagnosis:NASH	GENDER=F; BMI=49; ETHNICITY=White; AGE=38; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH015	Diagnosis:NASH	GENDER=M; BMI=44; ETHNICITY=White; AGE=58; AST=27; ALT=39; ALKP=41; TBIL=0.2; GLUCOSE=125
SUBJECT_SAMPLE_FACTORS           	-	NASH018	Diagnosis:NASH	GENDER=F; BMI=51; ETHNICITY=Black; AGE=44; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=96
SUBJECT_SAMPLE_FACTORS           	-	NASH019	Diagnosis:NASH	GENDER=M; BMI=34; ETHNICITY=White; AGE=73; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=107
SUBJECT_SAMPLE_FACTORS           	-	NASH021	Diagnosis:NASH	GENDER=M; BMI=28; ETHNICITY=White; AGE=59; AST=30; ALT=39; ALKP=63; TBIL=0.9; GLUCOSE=185
SUBJECT_SAMPLE_FACTORS           	-	NASH030	Diagnosis:NASH	GENDER=F; BMI=41.6; ETHNICITY=White; AGE=28; AST=24; ALT=24; ALKP=77; TBIL=0.1; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH031	Diagnosis:NASH	GENDER=F; BMI=41.5; ETHNICITY=White; AGE=46; AST=17; ALT=23; ALKP=94; TBIL=0.2; GLUCOSE=135
SUBJECT_SAMPLE_FACTORS           	-	NASH035	Diagnosis:NASH	GENDER=M; BMI=74.7; ETHNICITY=White; AGE=45; AST=23; ALT=30; ALKP=72; TBIL=0.3; GLUCOSE=84
SUBJECT_SAMPLE_FACTORS           	-	NASH037	Diagnosis:NASH	GENDER=M; BMI=44; ETHNICITY=White; AGE=53; AST=52; ALT=83; ALKP=98; TBIL=0.3; GLUCOSE=165
SUBJECT_SAMPLE_FACTORS           	-	NASH038	Diagnosis:NASH	GENDER=M; BMI=45; ETHNICITY=White; AGE=65; AST=36; ALT=37; ALKP=67; TBIL=0.3; GLUCOSE=97
SUBJECT_SAMPLE_FACTORS           	-	NASH039	Diagnosis:NASH	GENDER=M; BMI=48; ETHNICITY=White; AGE=35; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH044	Diagnosis:NASH	GENDER=M; BMI=61; ETHNICITY=Black; AGE=41; AST=22; ALT=24; ALKP=57; TBIL=0.6; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH057	Diagnosis:NASH	GENDER=F; BMI=47.3; ETHNICITY=White; AGE=53; AST=25; ALT=18; ALKP=71; TBIL=0.6; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH072	Diagnosis:NASH	GENDER=M; BMI=77.3; ETHNICITY=White; AGE=50; AST=29; ALT=12; ALKP=85; TBIL=0.8; GLUCOSE=207
SUBJECT_SAMPLE_FACTORS           	-	NASH074	Diagnosis:NASH	GENDER=F; BMI=31; ETHNICITY=White; AGE=52; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=169
SUBJECT_SAMPLE_FACTORS           	-	NASH084	Diagnosis:NASH	GENDER=F; BMI=63; ETHNICITY=White; AGE=48; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=120
SUBJECT_SAMPLE_FACTORS           	-	NASH087	Diagnosis:NASH	GENDER=F; BMI=52; ETHNICITY=Black; AGE=58; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=175
SUBJECT_SAMPLE_FACTORS           	-	NASH088	Diagnosis:NASH	GENDER=F; BMI=40; ETHNICITY=Black; AGE=27; AST=15; ALT=19; ALKP=134; TBIL=0.4; GLUCOSE=133
SUBJECT_SAMPLE_FACTORS           	-	NASH090	Diagnosis:NASH	GENDER=F; BMI=35; ETHNICITY=White; AGE=32; AST=15; ALT=20; ALKP=69; TBIL=-; GLUCOSE=110
SUBJECT_SAMPLE_FACTORS           	-	NASH003	Diagnosis:Normal	GENDER=F; BMI=47.3; ETHNICITY=White; AGE=46; AST=36; ALT=54; ALKP=76; TBIL=-; GLUCOSE=90
SUBJECT_SAMPLE_FACTORS           	-	NASH004	Diagnosis:Normal	GENDER=M; BMI=-; ETHNICITY=White; AGE=23; AST=106; ALT=95; ALKP=-; TBIL=0.7; GLUCOSE=97
SUBJECT_SAMPLE_FACTORS           	-	NASH006	Diagnosis:Normal	GENDER=F; BMI=-; ETHNICITY=White; AGE=40; AST=68; ALT=72; ALKP=74; TBIL=0.5; GLUCOSE=93
SUBJECT_SAMPLE_FACTORS           	-	NASH011	Diagnosis:Normal	GENDER=M; BMI=29.1; ETHNICITY=White; AGE=54; AST=40; ALT=22; ALKP=42; TBIL=0.9; GLUCOSE=101
SUBJECT_SAMPLE_FACTORS           	-	NASH014	Diagnosis:Normal	GENDER=F; BMI=36; ETHNICITY=Black; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=139
SUBJECT_SAMPLE_FACTORS           	-	NASH017	Diagnosis:Normal	GENDER=M; BMI=45; ETHNICITY=White; AGE=59; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=101
SUBJECT_SAMPLE_FACTORS           	-	NASH020	Diagnosis:Normal	GENDER=M; BMI=29; ETHNICITY=White; AGE=33; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH024	Diagnosis:Normal	GENDER=F; BMI=35; ETHNICITY=Black; AGE=43; AST=20; ALT=13; ALKP=71; TBIL=0.9; GLUCOSE=95
SUBJECT_SAMPLE_FACTORS           	-	NASH034	Diagnosis:Normal	GENDER=F; BMI=51.5; ETHNICITY=White; AGE=49; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=172
SUBJECT_SAMPLE_FACTORS           	-	NASH036	Diagnosis:Normal	GENDER=F; BMI=39; ETHNICITY=Black; AGE=45; AST=21; ALT=23; ALKP=111; TBIL=0.2; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH041	Diagnosis:Normal	GENDER=F; BMI=63; ETHNICITY=Black; AGE=27; AST=21; ALT=19; ALKP=86; TBIL=0.3; GLUCOSE=106
SUBJECT_SAMPLE_FACTORS           	-	NASH042	Diagnosis:Normal	GENDER=F; BMI=42; ETHNICITY=White; AGE=58; AST=18; ALT=16; ALKP=98; TBIL=0.4; GLUCOSE=105
SUBJECT_SAMPLE_FACTORS           	-	NASH043	Diagnosis:Normal	GENDER=F; BMI=52; ETHNICITY=White; AGE=39; AST=13; ALT=12; ALKP=76; TBIL=0.3; GLUCOSE=104
SUBJECT_SAMPLE_FACTORS           	-	NASH045	Diagnosis:Normal	GENDER=F; BMI=48; ETHNICITY=Black; AGE=43; AST=13; ALT=15; ALKP=90; TBIL=0.3; GLUCOSE=104
SUBJECT_SAMPLE_FACTORS           	-	NASH046	Diagnosis:Normal	GENDER=F; BMI=40; ETHNICITY=White; AGE=36; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=104
SUBJECT_SAMPLE_FACTORS           	-	NASH050	Diagnosis:Normal	GENDER=F; BMI=52.5; ETHNICITY=Black; AGE=38; AST=15; ALT=12; ALKP=75; TBIL=0.1; GLUCOSE=96
SUBJECT_SAMPLE_FACTORS           	-	NASH051	Diagnosis:Normal	GENDER=F; BMI=50.6; ETHNICITY=White; AGE=29; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH053	Diagnosis:Normal	GENDER=F; BMI=25.1; ETHNICITY=White; AGE=56; AST=26; ALT=14; ALKP=180; TBIL=0.8; GLUCOSE=140
SUBJECT_SAMPLE_FACTORS           	-	NASH054	Diagnosis:Normal	GENDER=F; BMI=30.8; ETHNICITY=White; AGE=83; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=90
SUBJECT_SAMPLE_FACTORS           	-	NASH060	Diagnosis:Normal	GENDER=F; BMI=39.7; ETHNICITY=Black; AGE=36; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=115
SUBJECT_SAMPLE_FACTORS           	-	NASH066	Diagnosis:Normal	GENDER=F; BMI=40.3; ETHNICITY=Black; AGE=52; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=95
SUBJECT_SAMPLE_FACTORS           	-	NASH067	Diagnosis:Normal	GENDER=F; BMI=39.2; ETHNICITY=Black; AGE=33; AST=17; ALT=14; ALKP=73; TBIL=0.2; GLUCOSE=87
SUBJECT_SAMPLE_FACTORS           	-	NASH070	Diagnosis:Normal	GENDER=F; BMI=25.7; ETHNICITY=White; AGE=53; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH077	Diagnosis:Normal	GENDER=M; BMI=33; ETHNICITY=White; AGE=67; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=193
SUBJECT_SAMPLE_FACTORS           	-	NASH078	Diagnosis:Normal	GENDER=F; BMI=45; ETHNICITY=Black; AGE=40; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=101
SUBJECT_SAMPLE_FACTORS           	-	NASH080	Diagnosis:Normal	GENDER=F; BMI=50; ETHNICITY=White; AGE=57; AST=26; ALT=28; ALKP=54; TBIL=0.3; GLUCOSE=155
SUBJECT_SAMPLE_FACTORS           	-	NASH082	Diagnosis:Normal	GENDER=M; BMI=34; ETHNICITY=White; AGE=73; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH085	Diagnosis:Normal	GENDER=F; BMI=32; ETHNICITY=White; AGE=63; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH086	Diagnosis:Normal	GENDER=F; BMI=38; ETHNICITY=White; AGE=35; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH089	Diagnosis:Normal	GENDER=F; BMI=52; ETHNICITY=White; AGE=49; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=-
SUBJECT_SAMPLE_FACTORS           	-	NASH091	Diagnosis:Normal	GENDER=F; BMI=29; ETHNICITY=White; AGE=68; AST=14; ALT=18; ALKP=66; TBIL=0.4; GLUCOSE=107
SUBJECT_SAMPLE_FACTORS           	-	NASH001	Diagnosis:Steatosis	GENDER=M; BMI=52.3; ETHNICITY=Black; AGE=37; AST=16; ALT=19; ALKP=58; TBIL=0.4; GLUCOSE=236
SUBJECT_SAMPLE_FACTORS           	-	NASH002	Diagnosis:Steatosis	GENDER=F; BMI=34.9; ETHNICITY=White; AGE=57; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH023	Diagnosis:Steatosis	GENDER=M; BMI=34; ETHNICITY=White; AGE=56; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=97
SUBJECT_SAMPLE_FACTORS           	-	NASH032	Diagnosis:Steatosis	GENDER=F; BMI=45; ETHNICITY=White; AGE=58; AST=27; ALT=20; ALKP=83; TBIL=0.9; GLUCOSE=89
SUBJECT_SAMPLE_FACTORS           	-	NASH033	Diagnosis:Steatosis	GENDER=F; BMI=40; ETHNICITY=White; AGE=58; AST=38; ALT=29; ALKP=102; TBIL=0.5; GLUCOSE=109
SUBJECT_SAMPLE_FACTORS           	-	NASH056	Diagnosis:Steatosis	GENDER=F; BMI=45.1; ETHNICITY=White; AGE=51; AST=38; ALT=28; ALKP=45; TBIL=0.5; GLUCOSE=99
SUBJECT_SAMPLE_FACTORS           	-	NASH058	Diagnosis:Steatosis	GENDER=M; BMI=42.7; ETHNICITY=Black; AGE=53; AST=28; ALT=34; ALKP=72; TBIL=0.6; GLUCOSE=174
SUBJECT_SAMPLE_FACTORS           	-	NASH059	Diagnosis:Steatosis	GENDER=F; BMI=49.8; ETHNICITY=White; AGE=45; AST=16; ALT=16; ALKP=84; TBIL=0.3; GLUCOSE=92
SUBJECT_SAMPLE_FACTORS           	-	NASH061	Diagnosis:Steatosis	GENDER=F; BMI=56.7; ETHNICITY=White; AGE=29; AST=64; ALT=50; ALKP=68; TBIL=0.8; GLUCOSE=91
SUBJECT_SAMPLE_FACTORS           	-	NASH062	Diagnosis:Steatosis	GENDER=F; BMI=56.6; ETHNICITY=White; AGE=51; AST=15; ALT=16; ALKP=58; TBIL=0.5; GLUCOSE=90
SUBJECT_SAMPLE_FACTORS           	-	NASH071	Diagnosis:Steatosis	GENDER=F; BMI=40; ETHNICITY=White; AGE=33; AST=15; ALT=12; ALKP=59; TBIL=0.4; GLUCOSE=85
SUBJECT_SAMPLE_FACTORS           	-	NASH073	Diagnosis:Steatosis	GENDER=F; BMI=80.2; ETHNICITY=Black; AGE=34; AST=11; ALT=11; ALKP=90; TBIL=0.4; GLUCOSE=163
SUBJECT_SAMPLE_FACTORS           	-	NASH075	Diagnosis:Steatosis	GENDER=M; BMI=33; ETHNICITY=White; AGE=67; AST=22; ALT=34; ALKP=96; TBIL=0.5; GLUCOSE=191
SUBJECT_SAMPLE_FACTORS           	-	NASH076	Diagnosis:Steatosis	GENDER=F; BMI=50; ETHNICITY=White; AGE=51; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=92
SUBJECT_SAMPLE_FACTORS           	-	NASH079	Diagnosis:Steatosis	GENDER=F; BMI=43; ETHNICITY=White; AGE=37; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=85
SUBJECT_SAMPLE_FACTORS           	-	NASH081	Diagnosis:Steatosis	GENDER=F; BMI=46; ETHNICITY=White; AGE=65; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=119
SUBJECT_SAMPLE_FACTORS           	-	NASH083	Diagnosis:Steatosis	GENDER=M; BMI=39; ETHNICITY=White; AGE=41; AST=-; ALT=-; ALKP=-; TBIL=-; GLUCOSE=106
#COLLECTION
CO:COLLECTION_SUMMARY            	Human samples were collected according to a protocol approved by Vanderbilt
CO:COLLECTION_SUMMARY            	University Medical Center's Internal Review Board (#120829) and under informed
CO:COLLECTION_SUMMARY            	written patients' consent prior to inclusion in this study. Sample sizes were
CO:COLLECTION_SUMMARY            	selected to minimize the invasive procedures. Plasma samples were obtained from
CO:COLLECTION_SUMMARY            	patients' blood collected during standard of care surgical procedures. Urine
CO:COLLECTION_SUMMARY            	samples were collected from patients' Foley catheters placed for standard of
CO:COLLECTION_SUMMARY            	care procedure. Liver samples were obtained from the excess tissue collected as
CO:COLLECTION_SUMMARY            	part of the standard of care liver biopsies performed at the time of surgery
CO:COLLECTION_SUMMARY            	that would otherwise be discarded. Subsequently, studies at University of
CO:COLLECTION_SUMMARY            	California, San Diego were conducted under further auspices of University of
CO:COLLECTION_SUMMARY            	California, San Diego Internal Review Board #121220.
CO:SAMPLE_TYPE                   	Plasma
#TREATMENT
TR:TREATMENT_SUMMARY             	-
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Plasma sample extraction. One hundred microliters of thawed plasma containing 4
SP:SAMPLEPREP_SUMMARY            	µl of internal standard mix were extracted with 500 µl cold (-20°C) 70% CH3OH
SP:SAMPLEPREP_SUMMARY            	by incubation in an ice bath for 30 min. After mixing by vortex at 4°C for 1
SP:SAMPLEPREP_SUMMARY            	min and centrifugation (4°C, 18,000 g, 10 min), the solvent was evaporated from
SP:SAMPLEPREP_SUMMARY            	the supernatant. The residue was dissolved in 200 µl of resuspension solvent,
SP:SAMPLEPREP_SUMMARY            	vortexed to mix (1 min at 4°C), and centrifuged (4°C, 18,000 g, 10 min) to
SP:SAMPLEPREP_SUMMARY            	remove any insoluble material. GPLs: GPLs from liver samples were extracted and
SP:SAMPLEPREP_SUMMARY            	analyzed by MS essentially as described in (20, 21). Extraction and analysis of
SP:SAMPLEPREP_SUMMARY            	plasma samples was according to previously published procedures (22).
SP:SAMPLEPREP_SUMMARY            	Cardiolipin, coenzyme Q, and dolichol: Lipid extractions were performed based on
SP:SAMPLEPREP_SUMMARY            	the Bligh and Dyer method with minor modifications (23-25). FAs and eicosanoids:
SP:SAMPLEPREP_SUMMARY            	FFAs were extracted essentially as previously described after supplementation
SP:SAMPLEPREP_SUMMARY            	with deuterated internal standards (Cayman Chemicals) (26, 27). Eicosanoids were
SP:SAMPLEPREP_SUMMARY            	isolated via solid phase extraction, utilizing 25 deuterated internal standards
SP:SAMPLEPREP_SUMMARY            	(28, 29). Sterols and oxysterols: Sterols and oxysterols were extracted using
SP:SAMPLEPREP_SUMMARY            	previously described methods (30). Neutral lipids: Cholesteryl esters (CEs),
SP:SAMPLEPREP_SUMMARY            	TAGs, and DAGs were extracted from weighed liver tissue (0.5-1 mg) suspended in
SP:SAMPLEPREP_SUMMARY            	0.5 ml PBS that had been homogenized by sonication. Extractions of plasma (0.05
SP:SAMPLEPREP_SUMMARY            	ml diluted to 0.1 ml with PBS), urine (1 ml), and tissue sonicates were carried
SP:SAMPLEPREP_SUMMARY            	out using 1 ml hexane:methyl t-butyl ether (1:1, v/v), essentially as previously
SP:SAMPLEPREP_SUMMARY            	described (31). Sphingolipids: Sphingolipids from liver, plasma, and urine were
SP:SAMPLEPREP_SUMMARY            	extracted following previously published procedures (32, 33), with the exception
SP:SAMPLEPREP_SUMMARY            	that methylene chloride was substituted for chloroform for the single-phase
SP:SAMPLEPREP_SUMMARY            	extraction of sphingoid bases.  20. Ivanova P. T., Milne S. B., Byrne M. O.,
SP:SAMPLEPREP_SUMMARY            	Xiang Y., Brown H. A. 2007. Glycerophospholipid identification and quantitation
SP:SAMPLEPREP_SUMMARY            	by electrospray ionization mass spectrometry. Methods Enzymol. 432: 21-57.  21.
SP:SAMPLEPREP_SUMMARY            	Myers D. S., Ivanova P. T., Milne S. B., Brown H. A. 2011. Quantitative analysis
SP:SAMPLEPREP_SUMMARY            	of glycerophospholipids by LC-MS: acquisition, data handling, and
SP:SAMPLEPREP_SUMMARY            	interpretation. Biochim. Biophys. Acta. 1811: 748-757.  22. Quehenberger O.,
SP:SAMPLEPREP_SUMMARY            	Armando A. M., Brown H. A., Milne S. B., Myers D. S., Merrill A. H., Jr,
SP:SAMPLEPREP_SUMMARY            	Bandyopadhyay S., Jones K. N., Kelly S., Shaner R. L., et al. 2010. Lipidomics
SP:SAMPLEPREP_SUMMARY            	reveals a remarkable diversity of lipids in human plasma. J. Lipid Res. 51:
SP:SAMPLEPREP_SUMMARY            	3299-3305.  23. Guan Z., Li S., Smith D., Shaw W., Raetz C. 2007. Identification
SP:SAMPLEPREP_SUMMARY            	of N-acylphosphatidylserine molecules in eukaryotic cells. Biochemistry. 46:
SP:SAMPLEPREP_SUMMARY            	14500-14513.  24. Tan B. K., Bogdanov M., Zhao J., Dowhan W., Raetz C. R., Guan
SP:SAMPLEPREP_SUMMARY            	Z. 2012. Discovery of cardiolipin synthase utilizing phosphatidylethanolamine
SP:SAMPLEPREP_SUMMARY            	and phosphatidylglycerol as substrates. Proc. Natl. Acad. Sci. USA. 109:
SP:SAMPLEPREP_SUMMARY            	16504-16509.  25. Wen R., Lam B., Guan Z. 2013. Aberrant dolichol chain lengths
SP:SAMPLEPREP_SUMMARY            	as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis.
SP:SAMPLEPREP_SUMMARY            	J. Lipid Res. 54: 3516-3522.  26. Quehenberger O., Armando A., Dumlao D.,
SP:SAMPLEPREP_SUMMARY            	Stephens D. L., Dennis E. A. 2008. Lipidomics analysis of essential fatty acids
SP:SAMPLEPREP_SUMMARY            	in macrophages. Prostaglandins Leukot. Essent. Fatty Acids. 79: 123-129.  27.
SP:SAMPLEPREP_SUMMARY            	Quehenberger O., Armando A. M., Dennis E. A. 2011. High sensitivity quantitative
SP:SAMPLEPREP_SUMMARY            	lipidomics analysis of fatty acids in biological samples by gas
SP:SAMPLEPREP_SUMMARY            	chromatography-mass spectrometry. Biochim. Biophys. Acta. 1811: 648-656.  28.
SP:SAMPLEPREP_SUMMARY            	Deems R., Buczynski M. W., Bowers-Gentry R., Harkewicz R., Dennis E. A. 2007.
SP:SAMPLEPREP_SUMMARY            	Detection and quantitation of eicosanoids via high performance liquid
SP:SAMPLEPREP_SUMMARY            	chromatography-electrospray ionization-mass spectrometry. Methods Enzymol. 432:
SP:SAMPLEPREP_SUMMARY            	59-82.  29. Dumlao D. S., Buczynski M. W., Norris P. C., Harkewicz R., Dennis E.
SP:SAMPLEPREP_SUMMARY            	A. 2011. High-throughput lipidomic analysis of fatty acid derived eicosanoids
SP:SAMPLEPREP_SUMMARY            	and N-acylethanolamines. Biochim. Biophys. Acta. 1811: 724-736.  30. McDonald J.
SP:SAMPLEPREP_SUMMARY            	G., Smith D. D., Stiles A. R., Russell D. W. 2012. A comprehensive method for
SP:SAMPLEPREP_SUMMARY            	extraction and quantitative analysis of sterols and secosteroids from human
SP:SAMPLEPREP_SUMMARY            	plasma. J. Lipid Res. 53: 1399-1409.  31. Hutchins P. M., Barkley R. M., Murphy
SP:SAMPLEPREP_SUMMARY            	R. C. 2008. Separation of cellular nonpolar neutral lipids by normal-phase
SP:SAMPLEPREP_SUMMARY            	chromatography and analysis by electrospray ionization mass spectrometry. J.
SP:SAMPLEPREP_SUMMARY            	Lipid Res. 49: 804-813. 32. Shaner R. L., Allegood J. C., Park H., Wang E.,
SP:SAMPLEPREP_SUMMARY            	Kelly S., Haynes C. A., Sullards M. C., Merrill A. H., Jr 2009. Quantitative
SP:SAMPLEPREP_SUMMARY            	analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole
SP:SAMPLEPREP_SUMMARY            	linear ion trap mass spectrometers. J. Lipid Res. 50: 1692-1707.  33. Sullards
SP:SAMPLEPREP_SUMMARY            	M. C., Liu Y., Chen Y., Merrill A. H., Jr 2011. Analysis of mammalian
SP:SAMPLEPREP_SUMMARY            	sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS/MS) and
SP:SAMPLEPREP_SUMMARY            	tissue imaging mass spectrometry (TIMS). Biochim. Biophys. Acta. 1811: 838-853.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	FFAs were analyzed by stable isotope dilution GC-MS after derivatization,
CH:CHROMATOGRAPHY_SUMMARY        	essentially as described previously (26, 27). This method quantifies 33 FAs
CH:CHROMATOGRAPHY_SUMMARY        	including all major and minor saturated FAs, monounsaturated FAs, and PUFAs
CH:CHROMATOGRAPHY_SUMMARY        	containing 12 to 26 carbons. Eicosanoids were analyzed by a stable isotope
CH:CHROMATOGRAPHY_SUMMARY        	dilution LC/MS method utilizing 26 deuterated internal standards (28, 29). The
CH:CHROMATOGRAPHY_SUMMARY        	metabolites were quantified after separation by reverse phase chromatography on
CH:CHROMATOGRAPHY_SUMMARY        	a 2.1 × 100 mm BEH Shield column, 1.7 µM (Waters, Milford, MA) employing an
CH:CHROMATOGRAPHY_SUMMARY        	Acquity UPLC system (Waters). Detection and quantification were performed on an
CH:CHROMATOGRAPHY_SUMMARY        	AB SCIEX 6500 QTrap mass spectrometer equipped with an IonDrive Turbo V source
CH:CHROMATOGRAPHY_SUMMARY        	(AB SCIEX, Framingham, MA), operated in negative ionization mode via MRM, using
CH:CHROMATOGRAPHY_SUMMARY        	standard curves generated from 145 authentic quantification standards (34). The
CH:CHROMATOGRAPHY_SUMMARY        	method analyzes an additional 13 metabolites based on authentic primary
CH:CHROMATOGRAPHY_SUMMARY        	standards, but which cannot be quantified due to the lack of appropriate
CH:CHROMATOGRAPHY_SUMMARY        	internal standards. Data analysis was performed using MultiQuant 2.1 software
CH:CHROMATOGRAPHY_SUMMARY        	(AB SCIEX). 26. Quehenberger O., Armando A., Dumlao D., Stephens D. L., Dennis
CH:CHROMATOGRAPHY_SUMMARY        	E. A. 2008. Lipidomics analysis of essential fatty acids in macrophages.
CH:CHROMATOGRAPHY_SUMMARY        	Prostaglandins Leukot. Essent. Fatty Acids. 79: 123-129. 27. Quehenberger O.,
CH:CHROMATOGRAPHY_SUMMARY        	Armando A. M., Dennis E. A. 2011. High sensitivity quantitative lipidomics
CH:CHROMATOGRAPHY_SUMMARY        	analysis of fatty acids in biological samples by gas chromatography-mass
CH:CHROMATOGRAPHY_SUMMARY        	spectrometry. Biochim. Biophys. Acta. 1811: 648-656.
CH:INSTRUMENT_NAME               	Multiple
CH:COLUMN_NAME                   	Multiple
CH:CHROMATOGRAPHY_TYPE           	Core G
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:MS_COMMENTS                   	-
MS:INSTRUMENT_NAME               	-
MS:INSTRUMENT_TYPE               	-
MS:MS_TYPE                       	Other
MS:ION_MODE                      	UNSPECIFIED
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS         	pmol/ml
MS_METABOLITE_DATA_START
Samples	NASH001	NASH002	NASH003	NASH004	NASH005	NASH006	NASH007	NASH009	NASH010	NASH011	NASH012	NASH013	NASH014	NASH015	NASH016	NASH017	NASH018	NASH019	NASH020	NASH021	NASH022	NASH023	NASH024	NASH026	NASH027	NASH028	NASH029	NASH030	NASH031	NASH032	NASH033	NASH034	NASH035	NASH036	NASH037	NASH038	NASH039	NASH040	NASH041	NASH042	NASH043	NASH044	NASH045	NASH046	NASH047	NASH048	NASH049	NASH050	NASH051	NASH052	NASH053	NASH054	NASH055	NASH056	NASH057	NASH058	NASH059	NASH060	NASH061	NASH062	NASH064	NASH065	NASH066	NASH067	NASH068	NASH069	NASH070	NASH071	NASH072	NASH073	NASH074	NASH075	NASH076	NASH077	NASH078	NASH079	NASH080	NASH081	NASH082	NASH083	NASH084	NASH085	NASH086	NASH087	NASH088	NASH089	NASH090	NASH091
Factors	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Cirrhosis	Diagnosis:Cirrhosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Steatosis	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:Normal	Diagnosis:Steatosis	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:NASH	Diagnosis:Normal	Diagnosis:NASH	Diagnosis:Normal
6k PGF1a	1.141	0.450	0.725	0.044	2.666	NA	0.752	6.838	0.489	3.705	NA	NA	NA	NA	NA	NA	NA	1.408	0.481	0.436	1.929	0.462	0.354	0.651	0.570	0.964	1.344	0.707	0.651	0.359	0.624	0.665	0.422	0.642	0.427	0.893	0.267	0.506	0.623	NA	NA	0.020	NA	NA	2.903	1.195	NA	0.345	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.218	NA	0.669	1.062	0.774	0.707	0.924	0.946	0.919	0.659	0.816	1.179	0.654	0.775	0.031	0.511	0.187	0.622	0.401	1.309	NA	0.069	0.305	1.224
TxB2	3.612	8.308	0.570	1.133	1.716	0.333	0.225	0.402	2.450	0.577	1.177	0.370	1.039	NA	0.354	1.942	1.437	5.505	2.948	0.722	2.992	0.909	2.263	1.179	1.975	0.001	0.752	0.960	1.179	1.052	10.979	6.494	9.521	1.179	25.543	11.534	6.321	0.914	1.179	11.585	2.772	0.743	1.446	9.494	0.646	1.286	0.247	2.250	1.723	0.261	1.342	NA	NA	2.126	7.124	1.661	1.278	0.957	3.162	0.426	NA	NA	NA	0.692	0.955	0.986	0.314	1.447	3.012	7.698	4.505	1.482	0.478	0.711	0.089	2.678	0.957	0.807	NA	0.073	0.831	0.196	13.788	2.454	0.950	4.544	1.215	0.174
PGE2	0.235	1.683	0.083	1.148	0.465	0.126	0.017	0.349	1.020	0.303	0.854	0.547	0.606	0.277	0.453	0.243	1.220	3.391	0.800	0.062	1.202	0.534	0.659	1.283	1.122	0.030	0.470	0.366	1.283	0.637	2.419	1.410	2.595	1.283	6.005	4.792	1.758	0.309	1.283	0.238	1.118	0.464	6.627	2.257	0.697	1.291	0.512	0.325	0.664	0.130	0.817	NA	NA	0.347	0.356	1.044	0.759	0.487	1.129	NA	0.388	NA	0.302	0.239	0.912	0.974	0.674	1.220	1.857	2.669	2.553	1.361	1.267	2.196	0.657	2.229	1.369	0.895	NA	NA	0.082	NA	NA	NA	NA	0.684	0.026	0.182
TXB1	0.166	0.167	0.013	1.283	0.198	1.354	NA	0.166	0.252	0.954	NA	0.095	NA	NA	0.300	0.127	NA	NA	NA	NA	NA	NA	0.120	NA	NA	NA	NA	0.314	NA	NA	0.470	0.161	NA	NA	0.786	NA	0.457	NA	NA	0.502	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1.751	0.133	0.133	0.155	0.172	0.648	0.116	0.115	0.104	0.152	0.201	0.172	0.057	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
dhk PGF2a	0.790	NA	0.648	0.184	1.237	1.439	1.649	1.051	2.109	1.915	0.045	NA	NA	NA	0.810	1.442	1.503	1.010	NA	NA	0.137	NA	NA	0.312	0.151	0.631	NA	0.071	0.312	NA	NA	NA	NA	1.180	NA	0.233	NA	NA	0.312	0.166	NA	NA	NA	0.847	1.176	NA	NA	2.763	0.353	0.468	NA	0.105	3.846	NA	NA	0.198	0.096	1.416	0.438	1.707	1.066	NA	NA	NA	2.530	NA	0.848	1.681	0.175	NA	0.544	1.546	0.420	0.651	0.345	0.118	NA	0.388	NA	NA	NA	NA	0.084	NA	NA	NA	NA	NA
dhk PGD2	0.409	0.939	0.517	NA	0.742	1.781	1.834	3.870	1.619	0.986	0.437	NA	NA	0.476	0.153	0.396	0.226	8.987	0.073	0.553	NA	NA	NA	NA	2.218	2.488	0.528	0.668	NA	NA	NA	NA	0.340	NA	NA	0.552	NA	NA	NA	1.565	1.076	1.164	1.174	1.373	1.762	2.003	1.238	0.714	0.938	1.181	1.277	1.009	0.402	1.725	1.222	0.928	1.318	1.337	1.511	1.321	1.007	1.439	1.694	0.969	1.549	1.801	2.071	2.247	1.370	1.145	1.443	1.280	0.857	1.318	2.143	2.568	2.217	3.238	0.421	0.338	0.906	0.325	1.140	1.601	0.440	0.566	1.411	0.782
20oh PGE2	NA	NA	NA	NA	NA	NA	0.359	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.059	NA	NA	NA	NA	NA	0.836	NA	0.051	1.734	0.395	NA	1.374	0.115	NA	NA	NA	NA	0.345	NA	0.233	NA	0.282	NA	NA	1.309	2.118	1.353	NA	0.872	NA	0.642	0.872	0.215	0.663	NA	NA	0.984	NA	NA	NA	0.167	0.760	0.226	1.005	0.369	0.119
PGFM	NA	NA	NA	20.183	NA	9.658	NA	NA	NA	83.219	NA	3.149	NA	0.760	15.318	3.765	29.946	NA	NA	NA	NA	NA	NA	7.570	NA	NA	NA	NA	7.570	NA	NA	NA	NA	19.547	NA	NA	NA	NA	7.570	1.414	3.750	10.889	2.355	13.063	19.434	26.596	0.023	9.051	10.233	0.113	2.134	1.937	11.284	3.962	2.258	3.570	1.536	9.997	3.692	15.860	15.721	9.011	2.689	13.168	15.213	NA	4.836	8.611	3.613	1.492	4.921	4.656	5.254	17.190	6.191	4.279	1.081	5.140	NA	NA	NA	NA	NA	8.823	4.147	NA	9.342	NA
tetranor 12-HETE	0.115	0.390	0.203	0.438	0.617	0.113	1.454	1.662	0.257	0.260	0.414	0.315	0.443	0.301	0.526	0.505	0.455	0.712	0.617	NA	1.678	0.205	0.593	0.017	0.271	0.187	0.590	0.160	0.017	0.324	0.032	0.195	NA	0.017	NA	0.041	NA	0.332	0.017	0.536	0.454	0.616	0.478	0.703	1.163	1.647	1.095	0.828	0.289	1.189	0.919	0.336	1.615	1.137	0.370	0.215	0.479	0.345	0.445	0.237	1.595	0.800	0.392	0.275	1.865	2.368	0.440	0.304	0.548	0.243	0.425	0.209	0.431	0.341	0.304	0.327	0.145	0.147	0.124	0.100	0.078	0.060	0.489	0.078	0.284	0.133	0.154	0.224
12-HHTrE	1.371	11.934	NA	0.982	2.315	NA	0.373	1.221	0.392	0.955	3.105	2.278	1.908	0.280	1.651	4.072	1.775	3.992	4.973	1.675	3.725	3.543	4.335	0.083	3.303	0.937	0.733	0.640	0.083	1.455	18.351	9.768	14.095	0.083	36.683	15.965	9.432	1.420	0.083	25.919	5.442	3.205	4.144	14.374	3.053	5.736	1.154	5.317	4.343	1.131	3.973	NA	2.475	5.121	13.019	3.973	4.457	2.941	4.829	1.933	2.175	0.638	1.435	1.158	4.450	3.819	0.903	2.659	3.620	9.834	8.568	3.845	2.045	1.160	0.288	3.638	1.816	1.943	NA	0.100	2.296	0.320	18.532	2.790	2.126	4.029	0.948	0.359
11-HETE	0.053	0.736	0.090	0.593	0.961	0.007	1.267	0.970	0.213	0.154	0.812	0.426	0.270	0.340	0.385	0.818	0.695	1.668	0.591	0.295	2.175	0.790	0.797	0.434	0.912	0.361	0.884	0.552	0.434	0.849	1.548	1.188	1.920	0.434	3.038	1.668	0.856	0.742	0.434	1.057	0.677	0.379	0.583	2.065	1.191	1.485	1.522	0.628	0.667	1.264	1.199	0.448	1.449	1.234	0.925	0.521	0.768	0.647	0.873	0.724	1.066	0.354	0.569	0.535	1.134	1.993	0.591	0.732	0.902	0.831	0.898	0.443	0.582	0.481	0.302	0.802	0.482	0.385	0.469	0.342	0.355	0.248	1.695	0.460	0.317	1.160	0.619	0.458
PGA2	0.262	0.786	0.226	0.356	0.769	0.695	0.648	1.629	1.061	0.469	0.465	0.260	0.266	0.254	0.276	0.536	0.105	2.660	0.289	0.356	0.063	0.039	0.197	0.071	0.548	0.055	0.334	0.249	0.071	0.093	0.147	0.109	0.246	0.071	0.103	0.382	0.209	0.089	0.071	NA	0.025	0.007	NA	NA	7.651	0.166	0.118	0.148	0.033	0.055	0.052	0.081	0.351	NA	0.066	0.307	0.379	0.392	0.300	0.012	2.164	0.140	0.039	0.050	0.228	NA	0.068	0.487	0.106	0.059	0.096	0.178	0.044	0.204	0.109	0.197	0.188	0.038	NA	NA	0.063	0.167	NA	0.041	0.001	0.145	NA	0.693
16 HDoHE	0.060	0.099	0.033	0.204	0.230	0.093	0.162	0.158	0.114	NA	0.036	0.059	NA	NA	0.131	0.069	0.041	0.093	0.016	0.299	0.692	0.048	0.709	NA	0.208	0.001	0.228	0.057	NA	0.136	0.469	0.713	0.794	NA	2.183	0.950	0.362	0.076	NA	0.021	NA	NA	0.107	0.127	0.155	0.459	0.211	NA	NA	NA	0.382	0.129	0.003	0.063	NA	NA	0.040	NA	NA	NA	0.413	NA	NA	NA	0.211	0.188	0.158	0.319	0.231	0.375	0.262	0.139	0.177	0.085	0.140	0.357	0.231	0.488	0.094	0.023	0.039	0.050	0.253	0.263	0.066	0.379	0.072	0.157
LTE4	NA	NA	NA	NA	0.301	NA	0.243	0.144	NA	0.102	0.002	0.035	0.002	NA	0.004	0.011	NA	0.075	NA	NA	NA	NA	NA	NA	NA	NA	0.342	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.695	NA	NA	NA	NA	0.046	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.049	NA	NA	NA	0.134	0.129	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.019	NA	NA	0.038	0.047	NA	0.036	NA	0.018	NA
5-HETE	1.079	2.689	0.939	2.470	4.253	0.430	3.734	3.673	0.926	0.173	1.923	1.614	0.756	1.438	1.241	2.430	3.264	2.153	1.097	1.192	5.754	2.596	2.019	2.957	1.360	1.276	2.613	1.673	2.957	3.110	2.574	2.477	3.970	2.957	1.556	1.351	1.809	3.137	2.957	2.577	2.603	1.078	1.032	3.262	2.363	3.713	4.174	1.123	1.519	4.429	4.601	1.003	2.962	2.028	1.723	1.887	1.800	1.085	2.150	1.597	3.095	1.280	1.164	1.983	3.084	5.246	2.048	1.349	2.328	0.999	1.481	0.867	1.492	2.698	0.748	0.918	1.051	0.779	0.709	0.127	0.312	0.009	0.776	0.045	0.023	1.519	0.869	0.978
9-HOTrE	0.077	0.371	NA	0.874	0.986	NA	0.913	0.886	NA	0.185	0.450	0.724	0.267	0.870	1.055	0.418	0.461	0.217	1.536	0.035	1.391	0.200	NA	0.192	2.837	0.117	1.711	0.038	0.192	0.303	0.634	0.159	0.207	0.192	0.252	0.257	0.096	0.412	0.192	NA	0.144	NA	0.483	1.253	0.400	1.565	0.278	NA	NA	1.144	0.421	0.223	1.144	0.581	0.082	0.124	NA	NA	0.270	0.462	0.782	NA	NA	NA	0.591	1.013	0.661	0.226	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.261	0.008	0.407	0.936	0.952	4.176	0.157	2.206	0.883	0.409
5-HETrE	0.063	0.206	0.125	0.436	0.566	NA	0.432	0.427	0.107	NA	0.147	0.045	NA	0.041	0.131	0.104	NA	0.864	0.214	0.072	0.673	0.385	0.214	NA	0.026	0.138	0.262	0.225	NA	0.387	0.005	0.133	0.331	NA	NA	0.046	0.292	0.333	NA	NA	0.151	0.033	NA	0.645	0.512	0.710	0.769	NA	NA	0.261	0.728	NA	0.605	0.497	NA	NA	NA	NA	NA	NA	0.937	0.060	0.107	NA	0.375	0.520	0.167	0.065	NA	NA	0.041	NA	NA	NA	NA	0.026	NA	NA	0.174	0.109	NA	NA	0.410	0.010	0.048	0.211	0.204	0.464
15-HETE	0.206	1.734	0.264	3.271	3.088	0.788	4.354	10.255	0.735	1.559	1.779	0.825	0.690	1.509	1.411	2.698	1.728	0.586	0.098	NA	3.257	0.497	0.996	0.217	0.109	0.179	0.556	0.012	0.217	0.445	0.855	1.347	1.137	0.217	3.046	1.216	0.281	1.278	0.217	0.740	0.520	0.078	0.385	2.442	5.532	3.883	2.534	0.698	1.596	2.586	2.167	0.849	4.660	2.979	1.113	1.088	1.431	1.300	1.645	0.489	2.944	0.300	0.771	0.783	2.112	2.853	0.779	0.980	1.749	1.136	1.562	0.587	1.143	1.329	1.066	1.044	0.835	1.044	2.224	1.014	0.697	0.472	3.032	1.165	0.678	2.268	1.054	1.435
13-HODE	7.981	18.158	4.442	35.164	49.265	3.906	28.919	46.186	7.217	7.484	17.952	16.782	9.456	10.616	24.089	13.471	13.286	11.956	31.502	6.077	48.410	15.919	14.453	10.948	46.737	9.803	32.102	5.589	10.948	17.912	22.299	12.096	16.554	10.948	20.649	18.017	10.793	15.378	10.948	11.725	12.940	10.177	16.243	42.142	38.400	46.321	23.689	8.959	8.798	43.053	14.231	11.226	40.557	20.960	13.906	11.538	12.845	10.195	15.082	13.994	29.159	9.674	8.038	13.206	31.644	51.426	17.278	15.053	9.420	8.041	7.252	7.694	8.462	12.072	9.292	12.045	10.784	7.511	13.817	10.469	8.187	13.819	23.648	36.371	6.641	37.374	16.528	10.653
13-HOTrE	0.447	1.962	0.409	0.902	1.867	NA	0.578	3.976	1.396	NA	NA	0.110	NA	NA	1.232	NA	NA	1.698	4.810	1.055	3.068	1.708	1.856	0.056	9.756	0.977	6.392	3.546	0.056	4.127	4.255	2.948	4.759	0.056	6.745	4.386	3.103	2.464	0.056	0.099	2.242	1.209	NA	3.437	NA	0.280	NA	NA	NA	NA	NA	NA	2.290	1.448	0.010	NA	NA	NA	0.248	NA	NA	NA	NA	NA	NA	NA	0.730	0.194	NA	0.075	NA	NA	NA	NA	0.017	0.502	0.134	0.190	0.979	0.460	0.203	0.661	0.668	3.818	0.372	3.486	0.793	0.225
15-HETrE	NA	NA	NA	0.227	0.181	NA	0.145	0.333	NA	0.127	0.145	0.101	0.032	0.171	0.125	0.126	0.136	NA	NA	NA	0.241	0.205	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.020	NA	NA	0.217	0.016	NA	NA	NA	0.168	0.210	0.049	0.043	0.689	0.497	0.789	0.301	0.018	0.227	0.620	0.172	0.236	0.501	0.488	0.139	0.065	0.181	0.046	0.289	0.208	0.417	0.102	0.252	0.101	0.423	0.671	0.113	0.053	0.222	0.057	0.197	0.025	0.012	0.113	0.161	0.130	0.100	0.055	0.167	0.086	0.089	0.175	0.430	0.175	0.086	0.347	0.133	0.086
8-HETE	0.732	0.785	0.696	0.409	0.974	0.543	1.055	0.769	0.681	0.121	0.356	0.661	0.066	0.379	0.249	0.772	0.415	0.282	0.311	0.494	0.647	0.891	0.578	0.515	0.472	0.574	0.153	0.091	0.515	0.690	0.540	0.442	0.444	0.515	0.427	0.317	0.547	0.691	0.515	0.696	0.214	0.222	0.164	0.782	0.817	1.040	0.883	0.485	0.276	0.630	0.725	0.097	0.866	0.660	0.268	0.503	0.230	0.378	0.084	NA	0.808	0.325	0.112	0.027	0.491	0.528	0.382	0.260	NA	0.017	0.275	0.259	0.031	0.408	0.087	0.146	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
10 HDoHE	NA	NA	NA	0.038	0.020	NA	0.183	0.159	NA	0.013	0.137	0.131	0.117	0.018	0.190	0.160	0.073	0.126	0.018	0.263	0.453	0.005	0.275	0.040	0.171	0.166	0.187	0.174	0.040	0.117	0.304	0.270	0.491	0.040	0.985	0.397	0.174	0.242	0.040	NA	NA	NA	NA	NA	0.085	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.044	0.143	NA	NA	NA	NA	NA	0.008	NA	0.114	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
8-HETrE	0.350	NA	0.010	NA	1.343	NA	0.896	0.598	0.337	NA	0.999	0.334	0.470	0.716	0.360	0.154	0.952	0.615	0.639	1.049	0.660	0.800	0.894	0.823	0.630	0.849	0.696	0.368	0.823	0.818	0.586	0.624	0.344	0.823	0.424	0.396	0.697	1.048	0.823	1.280	0.809	0.962	1.203	1.380	0.988	0.925	1.171	0.947	0.984	1.139	1.162	0.700	1.301	1.176	1.341	1.112	1.005	1.300	0.979	1.100	1.526	1.351	0.898	1.565	0.771	1.377	0.400	0.352	0.653	0.285	0.133	0.187	0.140	1.092	NA	NA	NA	0.101	NA	NA	0.003	NA	0.633	0.134	0.329	0.114	0.593	NA
12-HETE	2.670	20.180	1.184	10.458	15.357	0.943	4.677	4.484	2.568	3.933	20.992	4.524	9.825	4.322	2.321	9.919	0.848	11.709	16.820	23.568	22.405	9.892	62.725	1.056	12.181	1.474	2.510	5.255	1.056	9.993	37.576	27.163	53.869	1.056	73.602	47.379	24.699	2.454	1.056	5.958	5.920	6.459	2.724	35.136	5.937	11.079	4.142	2.670	10.195	4.224	12.028	2.007	3.078	13.684	15.612	2.449	10.875	5.617	14.352	2.219	4.984	0.953	3.129	2.190	7.949	8.524	4.095	43.365	24.271	41.848	30.907	21.429	10.579	0.641	4.287	35.428	14.087	21.410	3.952	6.181	5.767	1.452	33.164	12.719	12.430	11.841	7.391	4.040
12-HEPE	0.087	2.047	0.227	1.475	1.408	0.147	0.135	0.245	0.203	0.275	3.113	0.221	1.060	0.331	0.508	0.541	0.072	1.752	2.616	3.163	3.554	1.542	5.808	0.082	0.862	0.191	0.350	0.775	0.082	1.232	5.782	4.122	5.523	0.082	9.286	5.882	1.991	0.284	0.082	0.200	0.715	0.341	0.308	2.945	0.159	0.997	0.333	0.538	1.071	0.123	6.261	0.663	0.204	0.747	1.518	0.582	0.905	0.751	1.476	0.176	0.505	0.133	0.097	0.362	0.509	0.681	0.358	3.999	1.057	2.114	2.741	0.712	0.758	NA	0.295	2.432	1.496	4.433	0.326	0.414	0.581	0.365	1.375	0.572	0.729	0.716	0.952	0.475
14 HDoHE	0.916	5.834	0.281	1.627	4.149	0.189	0.781	0.689	0.426	0.476	5.047	0.570	2.889	0.832	1.013	1.481	0.026	3.915	2.767	7.419	4.619	1.942	19.967	0.002	2.691	0.018	0.280	2.892	0.002	3.261	11.898	12.245	12.996	0.002	37.119	14.723	7.767	0.659	0.002	0.125	0.761	0.495	0.202	4.596	0.751	2.060	0.576	0.002	1.143	0.404	3.347	0.666	NA	1.017	1.588	0.126	0.828	0.519	1.834	0.017	0.277	NA	NA	0.136	0.825	1.180	NA	2.857	1.238	4.260	2.364	0.783	1.014	NA	NA	2.974	1.658	5.178	0.970	1.815	1.163	0.816	1.789	2.174	1.881	2.202	0.882	0.784
11 HDoHE	NA	0.047	NA	NA	0.342	NA	0.143	NA	NA	0.013	0.489	0.173	0.279	NA	0.343	0.221	NA	0.230	0.073	0.638	0.597	0.360	1.043	NA	0.143	0.078	0.057	0.406	NA	0.443	1.040	0.740	1.062	NA	2.163	1.447	0.380	0.329	NA	NA	NA	NA	NA	0.591	0.052	0.379	NA	NA	0.041	NA	0.374	NA	NA	NA	0.133	0.024	NA	NA	0.414	NA	NA	NA	NA	NA	0.158	0.268	NA	0.440	0.475	0.661	0.159	0.037	NA	NA	NA	0.390	0.672	0.778	0.112	0.332	0.169	NA	0.140	0.232	0.077	0.047	0.045	0.079
9-HODE	4.389	11.785	2.050	26.088	43.615	1.554	15.297	20.989	5.372	2.556	7.963	12.587	4.383	5.789	11.563	7.626	10.721	8.017	22.257	4.365	34.478	7.726	5.473	10.345	25.824	12.127	18.973	4.723	10.345	8.830	13.723	7.557	8.033	10.345	11.519	16.225	5.879	10.637	10.345	7.690	9.574	6.180	10.631	28.706	15.516	35.359	13.364	6.352	6.633	30.172	13.957	7.076	21.460	12.733	9.410	8.865	7.351	6.417	9.041	7.312	17.323	6.076	5.054	10.039	18.045	39.128	13.160	12.448	6.261	5.777	5.717	3.813	5.586	8.950	5.193	9.152	5.867	5.205	8.391	7.853	6.269	10.720	14.124	34.638	6.768	31.173	14.461	10.094
HXB3	0.990	2.741	0.208	0.590	0.389	NA	0.020	0.424	0.011	2.492	12.201	2.256	4.207	4.798	1.800	3.603	0.783	3.033	5.170	6.545	21.527	3.181	5.689	0.208	14.480	NA	0.350	3.901	0.208	4.429	26.217	21.621	8.150	0.208	30.945	11.687	7.019	1.212	0.208	NA	0.116	0.622	NA	13.681	0.456	0.521	1.950	0.102	0.609	NA	0.900	NA	NA	0.101	2.376	NA	9.263	0.885	4.979	NA	NA	NA	NA	NA	0.921	NA	1.743	5.697	5.906	10.944	6.110	4.670	8.448	0.165	1.728	4.132	1.772	3.424	1.141	1.667	0.147	NA	0.799	3.071	0.225	10.356	0.402	1.609
9-oxoODE	NA	11.553	0.240	9.668	3.501	1.629	1.161	0.239	NA	1.544	4.537	10.319	3.942	4.361	6.664	3.582	4.013	1.208	12.667	1.166	22.716	2.235	1.789	3.657	6.666	0.304	3.196	0.961	3.657	2.437	9.601	4.077	1.520	3.657	3.380	2.119	1.446	1.834	3.657	17.124	0.485	1.263	1.305	8.240	6.663	5.863	10.972	1.284	3.097	2.567	5.495	1.324	6.944	4.008	4.389	3.136	2.301	2.558	4.313	2.670	5.478	1.010	2.466	1.452	4.017	45.900	17.782	2.813	16.789	19.706	12.084	10.040	9.756	3.100	10.849	4.784	12.149	8.972	1.330	1.928	0.505	0.591	4.109	3.719	0.167	25.800	2.723	2.434
13-oxoODE	0.484	8.219	1.219	4.910	1.927	6.181	4.264	0.788	1.603	NA	0.780	5.770	0.281	1.806	2.555	2.207	1.867	NA	1.497	NA	7.922	2.036	NA	0.095	2.248	0.377	0.756	0.471	0.095	0.539	4.338	2.122	0.993	0.095	0.616	1.614	1.752	2.278	0.095	7.671	NA	NA	1.038	3.746	4.314	1.117	4.836	NA	1.652	1.239	1.069	NA	3.027	2.746	NA	NA	0.108	NA	1.805	NA	0.636	2.164	NA	2.151	0.660	17.435	NA	0.194	NA	NA	NA	NA	NA	0.769	0.009	0.226	NA	0.505	NA	NA	NA	NA	0.647	2.186	NA	8.785	0.558	0.341
18-HETE	0.095	NA	NA	1.265	0.525	0.034	1.550	0.144	0.540	0.225	0.352	0.439	0.270	0.050	0.752	0.639	0.126	0.455	0.839	0.338	1.504	1.311	1.148	0.202	0.720	0.448	0.187	0.534	0.202	0.557	0.441	NA	0.745	0.202	0.334	1.325	0.394	1.155	0.202	0.367	0.351	0.356	0.113	0.324	0.889	0.758	0.308	NA	0.382	0.898	0.355	0.185	0.382	0.301	0.368	NA	NA	0.573	0.211	0.317	0.393	0.037	NA	0.630	1.246	1.160	0.441	0.525	0.474	0.499	1.145	0.689	0.326	0.201	0.330	0.335	0.198	0.253	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
16-HETE	0.231	0.769	0.293	0.981	1.008	0.026	0.936	0.483	0.057	NA	0.023	0.054	NA	NA	0.070	0.381	0.107	0.303	0.424	0.187	0.595	0.708	0.537	0.699	0.233	NA	0.214	0.553	0.699	1.153	0.790	NA	0.075	0.699	0.124	0.359	NA	0.099	0.699	1.098	NA	NA	NA	0.262	1.223	0.361	0.421	NA	NA	0.143	NA	NA	0.144	NA	NA	NA	NA	NA	NA	NA	0.611	NA	NA	NA	NA	0.274	0.260	0.356	NA	0.057	NA	0.221	NA	0.247	0.626	0.137	0.200	0.030	0.515	NA	0.044	0.441	0.443	0.813	0.685	0.561	1.037	0.703
19,20 DiHDPA	1.035	0.692	0.087	8.272	0.529	2.679	1.530	NA	0.583	1.581	0.588	0.523	1.174	0.908	1.043	1.732	0.957	1.190	2.087	1.672	7.192	3.465	1.689	1.524	1.324	0.381	1.817	3.474	1.524	3.675	1.132	0.880	0.893	1.524	3.892	2.170	1.075	6.505	1.524	1.237	0.547	0.171	0.326	1.715	1.176	11.589	2.458	0.091	0.838	5.809	3.314	1.305	1.088	0.771	1.601	0.395	0.553	1.635	0.962	0.249	3.933	0.431	0.797	0.744	5.362	6.307	1.177	2.476	1.297	0.790	2.066	2.074	2.164	0.843	2.380	1.265	1.983	2.079	1.612	NA	0.200	NA	0.998	0.963	0.141	NA	1.369	1.286
9,10 EpOME	1.993	6.305	2.257	12.625	9.320	2.078	7.822	8.116	3.733	1.602	2.997	5.691	1.926	3.768	3.888	3.613	3.185	2.475	3.482	2.564	14.017	6.665	2.816	2.418	7.895	3.735	4.757	4.261	2.418	5.315	8.257	3.297	5.331	2.418	3.955	2.695	2.926	6.670	2.418	2.557	2.135	2.862	1.565	8.004	14.995	15.705	16.817	2.480	2.804	14.211	3.838	2.163	9.854	4.340	7.370	4.142	3.969	3.528	3.136	7.807	11.285	2.075	1.692	5.925	12.785	11.537	4.897	4.606	3.411	4.756	3.099	1.821	4.539	2.494	3.695	3.990	3.476	4.246	1.530	1.834	2.399	3.194	5.914	9.753	1.940	36.464	3.787	4.725
12,13 EpOME	1.863	3.463	1.099	10.702	6.442	1.602	4.948	5.281	2.956	0.832	1.766	3.429	1.189	1.821	2.328	2.841	1.822	0.952	2.072	0.206	5.582	2.034	0.949	0.907	2.467	1.605	3.272	1.736	0.907	2.318	3.181	0.568	1.785	0.907	1.064	1.459	1.006	2.209	0.907	3.402	1.973	1.542	1.180	4.843	6.500	6.732	8.591	1.455	2.326	8.150	2.799	2.200	7.708	2.939	5.502	1.770	1.919	1.728	2.216	4.806	5.602	1.742	0.992	3.995	6.381	9.372	4.807	3.862	3.339	3.880	2.704	1.682	3.227	1.889	3.560	3.399	2.346	3.875	1.217	1.719	2.225	2.284	6.468	5.206	1.532	13.948	2.177	2.208
5,6-diHETrE	0.233	0.370	0.255	1.084	0.614	0.367	0.886	0.414	0.357	NA	0.466	0.013	0.145	0.040	NA	0.132	0.782	0.184	0.205	0.443	1.234	1.926	0.167	0.544	0.054	NA	NA	0.215	0.544	0.746	0.438	NA	0.370	0.544	0.646	0.942	0.550	2.865	0.544	0.445	0.921	0.295	0.397	0.302	NA	0.557	0.194	NA	0.529	0.326	0.443	0.128	0.862	1.905	1.221	1.322	0.314	0.583	0.374	NA	0.839	0.248	0.484	0.548	0.877	1.213	0.768	0.715	0.134	0.088	0.518	0.799	0.596	0.986	0.285	0.433	0.271	0.686	0.370	0.262	0.432	0.085	0.249	0.252	0.330	0.384	0.151	0.286
8,9-diHETrE	NA	NA	NA	0.921	1.301	NA	2.546	NA	NA	0.056	0.494	0.550	NA	0.106	1.210	0.876	0.613	0.433	0.566	1.657	3.000	2.185	1.051	0.033	1.517	0.593	0.169	0.866	0.033	1.862	0.450	0.486	1.247	0.033	1.473	1.719	0.467	2.368	0.033	0.781	0.939	0.519	0.676	0.497	1.025	1.860	0.931	0.046	0.788	1.347	1.324	0.743	1.520	1.343	0.689	0.966	0.873	NA	NA	0.078	3.348	0.190	0.571	0.572	1.546	2.944	0.485	0.125	0.798	0.064	0.755	0.671	0.370	0.509	0.010	0.392	0.252	0.319	0.826	0.232	0.245	NA	0.231	0.382	0.166	0.369	0.452	0.503
11,12-diHETrE	0.411	0.639	0.333	1.767	1.036	0.954	1.362	0.879	0.302	0.717	0.444	0.688	0.211	0.426	0.641	0.735	0.692	1.296	1.044	0.944	1.672	1.753	0.815	0.481	0.987	0.757	0.713	0.512	0.481	0.933	0.983	0.356	0.508	0.481	0.553	0.819	0.722	2.007	0.481	0.051	0.188	0.161	0.260	0.068	0.552	1.295	0.174	0.027	0.233	0.741	NA	0.332	0.984	0.593	0.303	0.410	0.123	0.123	0.372	0.050	2.036	0.073	0.055	0.439	1.080	1.490	0.453	0.173	0.338	0.371	0.912	0.758	0.455	0.461	0.568	0.278	0.162	0.153	0.513	0.291	0.439	0.031	0.142	0.270	0.252	0.143	0.365	0.705
14,15-diHETrE	0.423	0.569	0.238	3.310	0.426	1.358	1.029	0.336	0.501	1.126	1.082	0.926	0.739	1.160	0.678	1.518	1.393	1.435	1.227	1.350	4.149	2.561	1.101	0.858	1.887	1.054	0.939	0.870	0.858	2.405	1.569	0.698	1.830	0.858	1.792	1.968	1.014	3.626	0.858	1.166	1.903	1.198	1.442	1.761	3.128	4.433	2.212	1.072	1.252	3.667	1.307	2.124	2.966	2.708	1.757	1.582	1.884	1.888	1.372	1.173	6.127	1.215	1.402	1.852	3.788	5.040	1.335	0.858	1.244	0.629	1.527	1.148	1.251	0.982	0.979	0.900	0.837	0.763	1.227	0.905	0.756	0.388	0.812	1.098	1.024	0.840	1.311	1.463
9,10 diHOME	2.684	4.335	1.402	11.983	9.379	0.798	9.487	12.063	1.620	0.881	4.622	9.535	2.539	2.590	31.062	5.294	4.427	4.915	10.268	1.342	13.349	7.630	3.752	4.109	5.440	5.437	4.895	1.611	4.109	7.477	3.544	2.424	2.659	4.109	2.125	2.514	1.578	6.966	4.109	2.623	4.270	1.985	3.754	9.494	11.046	35.266	7.148	3.225	2.091	22.908	3.891	3.780	17.894	6.699	27.844	2.042	3.275	3.287	3.394	20.939	19.302	3.070	2.340	4.919	13.293	22.347	23.741	19.935	2.993	3.793	3.670	1.664	3.280	3.985	10.788	6.281	66.237	11.937	3.684	3.339	11.926	20.591	23.195	54.221	3.403	50.305	17.702	5.664
12,13 diHOME	2.440	4.339	1.268	10.273	19.668	0.437	10.363	16.908	1.551	1.253	5.899	8.053	2.886	2.491	22.552	4.785	5.082	5.060	9.555	1.986	13.840	6.435	3.466	5.393	6.896	5.439	4.665	2.217	5.393	9.542	4.992	3.817	3.933	5.393	2.207	3.923	1.530	7.249	5.393	3.652	7.375	3.133	6.369	12.405	11.886	31.563	11.028	4.002	2.611	25.060	5.062	4.754	23.051	9.819	12.419	3.475	4.587	3.361	5.595	10.195	21.268	5.304	3.458	6.301	14.864	21.573	18.384	10.334	3.233	5.210	4.065	1.714	3.988	5.223	4.811	4.348	31.654	6.635	4.598	3.725	4.665	11.795	12.820	26.587	3.152	19.883	9.660	4.333
20cooh AA	5.567	8.690	5.436	36.126	70.658	8.791	42.685	72.612	6.303	13.864	22.589	111.684	10.758	9.047	50.054	59.128	37.116	40.467	13.419	12.818	78.003	35.070	15.540	20.472	38.437	22.685	88.752	11.405	20.472	21.418	14.516	7.707	17.637	20.472	23.951	31.557	12.019	62.923	20.472	9.925	24.077	16.323	8.591	15.192	76.812	94.057	44.514	9.624	19.673	102.567	48.749	14.868	35.140	35.562	27.707	27.991	20.481	11.202	8.709	14.628	177.008	9.911	8.415	14.528	85.792	123.804	35.316	40.028	63.460	14.770	47.185	28.237	19.233	40.141	9.800	33.028	30.084	12.768	21.659	5.107	14.612	2.625	4.565	9.743	7.680	9.755	20.374	14.513
2,3 dinor TXB2	59.960	54.872	19.336	32.502	15.862	65.332	30.779	NA	20.752	36.864	7.877	8.874	14.106	7.271	16.613	12.421	6.161	NA	NA	NA	0.308	NA	NA	10.294	NA	0.971	2.237	0.853	10.294	1.339	0.718	1.948	16.255	10.294	NA	1.772	9.670	7.462	10.294	1.358	NA	NA	NA	NA	1.577	NA	NA	NA	5.382	NA	NA	NA	3.617	NA	NA	NA	NA	NA	NA	0.304	NA	0.066	NA	NA	NA	9.521	NA	2.175	NA	NA	NA	NA	4.092	1.179	NA	10.549	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FA(14:0)	1911.1	7074.6	2697.3	20796.0	29055.5	795.7	17231.7	9948.6	5883.7	1925.6	9573.9	12282.4	3374.8	7085.6	9235.6	8506.9	10033.2	6321.1	13836.3	11878.2	37366.6	22802.1	11498.5	34665.7	9890.6	18115.3	16672.9	13084.2	11256.8	20234.8	17495.7	12904.8	12714.4	19329.8	16721.0	20349.3	7843.3	21352.6	20895.7	20421.5	24130.7	12566.5	18883.0	41537.1	26984.8	40610.6	22395.4	14299.9	16634.5	40847.6	14104.6	11900.0	31191.4	29717.2	11934.0	14717.4	12546.2	17120.2	18530.1	12399.9	44370.5	34960.5	13018.1	13917.8	15215.5	54444.8	28828.9	17423.7	11363.4	11095.1	23378.0	7757.7	9033.9	12918.2	7474.4	14394.6	12226.5	7792.8	10532.5	11096.5	10911.4	5981.2	18352.8	9019.4	8414.7	11007.1	14985.9	15941.0
FA(15:0)	439.5	884.9	294.0	1943.4	2380.4	53.4	1676.5	1120.6	707.0	332.3	1006.2	910.9	314.1	988.0	748.9	1034.8	1219.8	839.8	1603.0	1299.2	3243.9	1507.8	1489.3	3028.8	960.8	2167.5	1343.7	1789.4	1390.3	2418.0	2735.5	1308.5	1706.9	2657.5	2280.4	2833.4	1234.5	2411.2	2374.6	2797.8	2747.2	1902.7	2621.2	3992.7	2304.8	3227.3	2126.2	1408.5	2274.0	4348.0	1769.9	1635.3	3069.0	3070.7	1433.8	2071.9	1785.7	1838.2	2150.3	1463.9	3193.1	3081.2	1372.5	1312.6	1617.2	5069.4	3071.0	2355.1	1917.9	1256.7	1736.4	1163.6	1398.9	1869.6	1033.0	1928.5	1659.7	1099.9	1634.9	1527.0	1528.6	842.7	1503.0	1180.7	887.1	1471.5	1507.1	1990.0
FA(16:0)	42232.4	80983.3	38658.8	134891.4	134516.0	14075.6	112439.3	76951.1	101973.7	37066.4	56026.5	84251.6	59978.4	92602.6	67362.1	90559.8	108824.7	65917.7	97778.8	95701.8	130990.8	133820.3	89386.2	134960.1	78066.9	90056.0	93847.1	85839.3	79567.0	100212.6	98743.2	90622.0	101017.6	97879.4	128709.1	112147.6	70684.9	112129.2	123856.7	100688.4	115064.6	90798.2	106878.2	169262.5	108610.3	146864.1	104575.7	87612.9	106316.5	117864.2	141266.0	103570.5	135075.5	121028.9	142809.7	129904.6	100856.2	107247.6	135684.1	97488.7	153554.7	164454.2	105345.7	95963.9	80138.6	161006.6	128564.3	150128.7	70215.3	113259.5	146540.7	111234.0	135717.8	118623.5	92942.2	117855.0	108774.6	79118.6	121493.2	121867.0	124090.1	74687.7	112632.9	107817.8	109749.9	103088.0	114463.8	125533.1
FA(16:1)	2212.1	17744.9	7800.3	45131.4	65876.3	1853.4	33644.7	18532.5	12104.5	3877.4	9205.6	24822.2	3591.9	14001.9	14087.6	23247.1	24818.3	9462.6	20255.1	20640.9	59566.1	48783.9	21254.9	73868.5	22084.5	24142.1	43765.5	18952.5	25902.2	41275.3	31767.6	25159.7	40430.1	18141.7	14361.3	32020.0	21095.2	36831.5	33218.1	38178.6	32450.7	15091.2	15798.5	38891.9	48272.1	39770.7	35280.7	27606.0	42901.7	61865.6	17538.4	18343.2	48873.0	35383.7	15419.6	12280.3	15820.8	16274.6	36732.7	24539.6	68740.0	39459.1	13481.5	8178.9	27617.6	76904.0	29199.8	14011.8	7507.8	14983.6	40103.2	9607.2	8723.6	10392.2	8445.0	15889.3	11188.0	10106.0	20625.4	40415.4	32427.4	7557.8	50874.7	15841.1	11099.3	21126.8	52492.0	49495.8
FA(17:0)	900.9	1210.9	542.9	2107.2	1565.4	186.2	1535.5	1231.4	1739.4	774.1	1783.0	1006.0	1146.8	1656.1	833.2	1996.0	1760.9	1513.5	2388.1	2089.6	3198.1	2454.4	2476.7	2519.8	1909.0	2027.5	1528.3	1820.5	1705.7	2427.1	2939.7	2496.8	2874.3	3793.3	4106.3	3944.1	1836.7	3483.2	3751.4	2849.0	3359.7	2714.7	3516.7	3550.2	1584.4	3257.2	1923.6	2206.2	2963.1	2835.1	3313.8	3344.2	3546.5	4496.5	2423.0	4838.6	2925.5	3452.6	2525.8	2510.8	2705.3	2856.2	2954.8	3103.3	2033.7	3013.1	2932.6	2679.7	1774.2	2661.2	2156.3	3927.4	2654.7	3426.4	3174.4	3043.2	3098.8	1979.3	2820.0	2274.7	2799.7	1387.2	2190.2	2575.8	2821.9	2395.4	1975.3	3579.1
FA(17:1)	353.0	1295.3	664.9	3244.3	3695.8	123.7	2671.4	1337.0	1196.6	626.9	903.8	1199.6	335.0	1305.8	770.9	2518.0	1860.0	606.0	1248.3	1250.6	3207.4	2096.8	1329.5	4609.7	1152.6	1426.3	1716.8	1124.1	1297.1	2187.1	1866.3	1284.2	2625.5	1402.5	1556.8	2008.3	1232.8	2310.1	1884.0	2531.7	2105.2	1132.8	1406.8	2173.7	2155.2	2883.1	1695.7	1666.4	3144.7	3996.9	1745.5	1176.1	3980.4	2180.6	1559.4	1278.5	1189.6	1163.4	3120.0	1394.4	3479.2	2979.3	972.6	873.8	1602.3	4324.6	1511.5	1105.9	526.2	775.6	1945.3	623.7	619.5	672.4	536.0	784.2	591.2	530.5	2173.4	6705.2	4008.0	890.6	2666.6	1244.4	1049.7	1476.5	2554.3	3096.9
FA(18:0)	22472.4	23236.8	10869.4	28829.3	20144.5	5090.0	23752.2	19627.6	34634.5	11090.9	36423.5	16657.5	29475.9	28715.0	17859.3	35046.5	28803.6	26873.3	32624.3	37009.7	43308.6	44583.4	32794.9	28914.4	32582.3	28723.4	26712.1	26509.0	28224.8	35292.6	35178.6	40494.0	40467.5	40619.9	59988.4	47758.7	26140.2	45840.1	51607.0	35415.0	51813.8	37576.3	47103.4	57675.1	25215.2	37849.7	32472.6	38734.7	44562.0	32642.7	53426.7	47384.9	51472.7	59691.4	46189.8	68822.2	43303.9	53882.2	44867.1	40981.0	39508.5	40275.0	52667.8	57792.0	33390.4	36096.2	56875.0	52895.9	25292.9	47445.5	43825.0	60618.0	51771.8	56750.6	54553.5	51076.8	59551.1	38678.4	44416.2	36025.2	38400.9	29406.5	33437.6	47191.4	56680.9	42459.4	41177.4	46837.4
FA(18:1)	23088.0	25038.7	19038.3	24889.3	24366.3	13266.3	23849.1	26735.5	25504.6	20540.3	25178.4	25593.0	23579.1	26292.5	24880.1	25361.8	25072.9	20120.7	19930.7	19546.9	20314.4	18017.0	21188.7	19454.9	18694.6	19266.7	18965.8	25989.7	19843.2	17150.8	30410.2	25483.3	19125.3	18167.5	23940.5	20572.3	19001.7	26501.9	19910.0	15703.9	16613.5	17015.5	17758.5	20320.2	16661.1	25172.1	21178.9	16571.2	14255.4	14815.4	29010.5	202.3	17510.5	17157.4	26531.9	16536.9	17211.1	16026.9	18096.1	16150.4	15897.0	23857.1	17018.4	26033.0	17182.6	17007.2	14434.1	18038.1	21614.3	11260.4	11782.2	13840.8	22281.1	15965.5	12891.4	13805.4	14472.9	12975.8	24075.9	23847.3	27947.0	22186.2	17028.4	18337.5	19932.7	23046.5	17939.1	15079.4
FA(18:2)	24346.2	23328.2	16608.9	26377.6	22418.3	10748.2	25326.6	28001.0	19382.5	18609.9	18302.7	24027.7	19418.4	21139.1	28595.6	20749.7	27263.8	22425.4	27380.0	22473.6	26120.3	30136.0	23160.9	25757.0	24904.8	25826.6	24533.2	27543.3	25271.8	21355.6	24610.1	27888.3	24943.9	25433.7	23618.4	27001.2	23751.7	36967.0	28784.6	22150.3	22232.0	22005.9	24130.8	25824.0	23555.6	24556.6	28944.3	22250.9	21229.8	24647.0	26913.6	24915.9	25177.8	24272.6	31205.9	22506.6	21955.9	23914.8	21951.3	22366.9	21977.4	20937.6	22047.6	22709.8	20750.6	26529.0	27021.1	31761.8	30790.4	29651.1	21732.6	27191.2	26040.3	36951.8	29275.8	29486.1	30309.0	27309.9	31871.7	37020.2	36461.6	41144.4	25461.0	35782.9	29560.6	38987.7	28256.8	27761.7
FA(18:3 N3)	69.0	52.7	69.0	186.9	100.8	51.9	110.6	88.0	53.1	44.1	96.2	98.1	54.2	83.1	123.3	89.6	141.2	134.8	422.7	240.9	367.7	638.7	233.2	274.6	242.9	188.9	343.4	241.1	196.1	265.8	244.3	417.9	328.6	423.4	123.2	423.6	242.6	385.1	492.5	290.6	226.2	118.7	124.4	131.0	160.9	101.5	222.8	158.2	216.4	246.7	131.2	188.2	180.0	289.7	99.2	128.5	160.9	153.9	103.4	140.9	314.0	145.1	114.7	120.4	160.4	242.4	182.3	105.6	208.1	171.6	187.6	94.0	96.0	106.8	120.5	133.2	184.9	131.3	148.3	158.5	197.2	181.1	316.7	143.5	210.1	217.8	256.6	545.4
FA(18:3 N6)	2417.2	2322.1	1353.7	2844.1	2347.4	827.2	2510.5	3068.5	1328.2	1590.3	1574.7	2145.4	1627.3	1800.2	3323.9	1958.6	2285.5	2164.0	2441.8	1882.1	3631.9	4261.1	1979.9	3162.4	2542.4	2391.2	2988.4	2714.1	2883.5	1995.3	2467.2	2405.8	2463.8	2454.6	1970.6	2813.6	1828.1	3525.2	2578.4	1864.9	2364.9	1961.7	2888.4	2733.3	2449.8	2526.9	3276.9	2444.3	1894.6	3339.9	2430.3	2799.0	3104.1	2112.0	2894.2	2118.9	2020.9	2662.4	2006.3	2721.3	2892.3	2349.3	2232.6	2240.4	1767.4	3551.3	3176.0	3087.0	2744.9	2629.9	2021.6	1799.0	1658.9	3987.6	2510.5	2529.9	2696.2	2622.3	3141.6	3287.4	3404.0	4631.7	3372.0	5064.1	2826.5	4603.0	3456.7	3148.0
FA(18:4)	11.3	6.2	10.3	20.5	12.2	4.7	13.0	14.5	5.2	6.1	11.4	14.1	5.6	8.4	19.7	9.2	15.4	7.9	32.2	12.7	56.8	75.9	13.9	36.5	16.8	15.1	32.9	104.1	17.7	24.1	18.0	37.7	28.4	36.1	10.0	40.9	13.1	33.0	43.0	25.8	29.9	13.7	15.9	18.1	22.0	23.0	33.0	22.8	24.6	43.1	20.5	24.7	31.9	26.5	11.1	17.8	12.7	13.9	11.8	13.8	53.4	32.2	13.2	16.4	18.1	38.5	16.0	3.7	79.4	7.5	11.9	NA	8.9	2.1	1.6	5.3	6.6	6.2	16.4	14.2	42.0	24.9	38.9	15.6	20.3	18.9	30.8	65.7
FA(20:0)	91.3	45.6	27.2	108.5	116.9	14.8	84.4	68.8	55.9	20.4	55.2	89.9	52.1	85.6	89.9	51.4	38.8	69.6	248.5	153.9	303.4	384.6	83.4	115.6	141.8	84.2	180.4	362.9	133.6	114.7	97.9	97.8	67.5	126.1	157.1	142.4	62.1	90.7	103.4	60.4	120.1	74.5	93.2	149.4	102.1	218.5	72.3	74.6	90.6	165.8	129.8	130.8	142.4	136.8	140.2	147.6	77.3	98.2	82.8	124.1	111.4	212.4	107.2	178.0	179.0	134.0	253.3	149.0	499.9	47.9	57.9	143.2	267.1	128.2	122.4	94.9	150.0	87.1	83.4	163.1	245.5	159.9	80.3	194.4	150.7	142.9	135.6	132.0
FA(20:1)	338.6	526.4	239.4	1329.7	875.1	76.1	1286.0	538.2	621.9	312.7	351.6	791.1	433.1	455.4	594.0	1054.5	624.3	341.4	628.5	785.0	1433.0	1062.6	494.6	1333.3	907.3	592.3	540.7	407.7	336.3	769.3	799.0	600.7	834.9	590.2	856.0	808.5	448.0	1585.7	931.3	690.0	1186.2	460.5	740.3	966.3	1120.7	1111.0	683.7	716.1	1639.8	1392.6	882.8	855.8	1573.5	1075.8	915.5	1216.7	449.4	698.2	1246.2	619.9	1374.9	1104.5	541.1	486.2	932.7	1465.0	491.5	360.1	245.8	259.9	521.8	532.9	375.4	349.0	492.4	329.6	415.4	296.1	978.9	7175.5	1155.5	807.4	850.1	1108.5	1238.0	1168.9	1734.3	1778.0
FA(20:2)	691.1	1517.0	465.2	1701.6	1908.4	325.3	2908.0	1812.0	1698.0	538.3	1791.4	2584.6	1449.7	1221.8	1130.8	1517.1	2011.3	973.9	1855.3	1504.5	3864.7	3240.1	2025.0	4108.0	2693.0	1879.6	1237.9	1797.4	1184.4	2430.4	2345.5	1783.0	2822.4	1775.9	2344.4	2262.1	1746.4	5366.8	2701.2	1908.9	2441.3	1576.5	1960.6	2793.4	4621.4	4659.7	3099.8	1530.2	2589.8	3125.5	3221.0	2960.3	2192.4	3285.6	2034.0	3973.9	1870.8	2533.5	1760.0	2498.8	5736.6	3126.2	2016.1	2129.2	1772.6	6822.0	2156.1	2056.9	2301.9	2448.6	2757.2	4053.8	3364.9	3395.5	4018.6	3063.1	3102.1	1876.1	1506.1	1346.4	1174.9	691.2	985.4	1926.2	2080.7	2181.1	1826.6	1895.1
FA(20:3 N3)	20.8	36.8	21.7	160.0	87.4	19.8	136.0	55.3	58.8	25.1	157.7	89.9	76.7	102.4	88.2	87.7	140.5	93.3	189.1	184.8	296.4	346.3	173.7	271.6	132.2	104.1	128.9	458.2	103.0	198.7	147.9	138.5	226.1	189.9	157.0	161.7	85.4	175.1	245.5	203.9	209.7	134.7	131.6	237.2	176.9	263.0	205.8	88.9	155.9	235.6	172.1	111.1	167.1	217.7	143.6	185.8	153.1	162.1	130.4	105.0	273.3	114.7	109.3	205.7	87.7	247.2	229.8	272.8	607.2	146.5	467.7	264.5	388.5	123.2	127.3	102.7	137.2	76.9	93.4	87.0	129.8	42.0	191.0	96.2	138.1	102.9	144.8	373.4
FA(20:3 N6)	269.1	750.4	308.9	1150.1	637.8	231.3	1507.6	608.5	963.2	276.2	1078.9	1083.1	473.6	904.9	470.9	704.9	1529.9	705.4	1899.8	1759.6	1393.0	2265.9	1346.4	1012.7	796.0	877.4	663.0	1138.9	567.3	1576.6	1187.1	1164.5	1496.2	1970.8	1312.6	1734.8	951.0	1541.3	1666.4	1565.8	1703.6	962.1	1229.8	2424.4	963.0	1433.7	1128.6	685.6	1774.5	1318.1	1383.2	1306.3	1144.8	1715.4	1220.4	1652.9	1197.8	1044.8	1289.9	994.0	2181.2	1333.0	757.2	935.0	549.8	2919.8	1557.1	1947.9	1624.9	1404.6	1775.5	1256.3	1507.7	1499.4	1105.3	1108.8	1959.8	1061.6	1259.3	1021.8	958.8	532.1	1423.3	1404.2	1440.6	1292.7	1549.5	1970.1
FA(20:3 N9)	75.3	220.2	61.7	290.6	393.3	34.7	455.0	279.6	206.7	65.4	249.1	362.1	184.4	170.5	157.3	230.4	355.1	126.3	236.6	168.3	659.5	402.6	260.2	654.8	305.5	294.4	169.6	523.2	136.2	304.6	285.2	253.8	408.3	255.6	310.6	349.6	238.8	962.7	393.4	229.5	428.8	212.5	398.9	491.4	690.2	930.5	516.3	261.7	384.4	556.2	521.1	512.7	341.4	440.1	274.6	611.2	266.6	363.0	290.9	409.9	1091.0	582.3	1081.4	432.4	179.1	1392.3	271.5	204.4	572.3	312.2	430.6	424.9	409.7	448.1	572.5	393.1	366.8	234.3	225.5	199.5	187.4	105.3	188.1	296.0	311.8	291.1	249.7	273.3
FA(20:4)	1288.5	1919.7	912.9	3719.3	2015.6	777.1	3540.7	2023.3	1756.7	1183.3	2980.5	3103.9	2165.2	3051.0	2036.1	3599.7	4312.0	3835.9	5103.2	6695.8	5646.9	7252.3	6272.5	5679.8	3643.2	2743.1	2162.2	2930.3	3287.4	5248.5	5466.5	4448.7	7214.1	5678.9	5881.7	6684.3	3937.7	6153.1	7672.4	7012.8	7081.4	3976.2	4561.7	6463.1	3203.5	4748.9	4593.1	3029.1	5500.0	5553.4	4877.5	4935.8	3819.8	5576.7	4963.1	6590.4	5441.5	5533.0	3945.9	3272.8	6148.9	3435.1	3889.5	3943.2	2386.3	7421.7	4914.7	5091.6	3575.6	4554.7	6418.8	6428.4	5379.4	4266.0	3023.0	2851.2	4243.6	2894.6	6316.1	5553.0	3799.6	2259.8	3077.0	5237.9	5473.0	4786.5	5457.0	6561.5
FA(20:5)	90.1	133.4	62.1	310.1	193.4	45.1	198.6	125.8	112.6	70.6	276.6	149.7	191.0	255.7	285.1	212.2	258.4	273.0	609.1	657.4	567.4	890.9	414.3	418.1	168.0	214.5	143.8	710.1	300.1	425.1	483.1	436.2	583.0	546.0	612.5	683.5	233.9	526.3	676.3	431.4	622.0	300.2	482.3	536.9	204.9	483.7	360.1	246.7	460.2	467.9	703.3	651.1	405.1	463.2	299.9	748.5	339.8	356.6	326.1	264.6	504.0	636.2	275.5	200.9	169.0	600.1	423.9	507.2	565.7	257.3	596.1	299.9	373.0	322.1	225.1	271.9	497.8	586.1	456.7	430.6	451.0	160.2	375.9	394.2	504.4	379.3	573.9	710.7
FA(22:0)	105.8	68.0	15.8	42.0	90.2	12.0	55.0	51.2	37.1	19.1	36.0	46.3	23.4	70.6	94.2	21.4	33.8	43.4	414.5	127.6	251.5	507.3	68.6	83.5	102.8	48.2	184.7	306.0	139.2	82.9	54.0	78.2	44.3	84.3	97.3	111.6	50.8	53.6	59.4	25.7	52.0	25.9	46.5	40.2	13.1	127.9	20.5	30.1	39.6	90.9	80.9	81.6	95.4	77.9	133.9	67.3	59.0	51.2	29.8	127.9	28.7	19.1	44.3	90.8	79.8	50.8	242.3	211.5	493.4	38.4	46.2	91.4	232.0	163.9	91.0	73.7	237.3	115.1	65.9	118.8	125.6	144.0	98.8	309.6	157.8	143.4	117.1	109.7
FA(22:1)	64.2	65.3	21.5	86.8	106.6	36.6	115.5	108.2	98.2	23.3	124.7	170.7	106.3	72.6	89.3	62.5	37.2	65.6	239.8	195.1	475.2	315.2	154.6	222.7	294.8	158.1	232.2	725.3	126.7	175.8	146.9	148.3	158.3	175.1	204.7	157.2	106.2	210.6	141.1	103.2	132.2	96.8	100.8	150.0	222.8	348.0	214.9	94.0	130.8	261.3	208.0	229.3	157.0	166.0	81.1	322.3	145.1	150.8	56.9	95.4	310.8	437.9	193.8	144.1	357.3	291.6	168.4	204.2	2695.8	106.4	181.0	572.7	1066.3	297.3	140.3	141.7	233.5	96.3	58.8	19.8	57.8	29.0	37.1	60.3	74.5	61.0	58.6	65.2
FA(22:2)	41.5	58.4	21.1	57.6	90.8	23.9	95.4	97.8	78.4	15.4	91.4	133.7	55.7	41.3	57.2	40.0	46.0	22.0	66.1	79.3	263.5	143.2	98.6	208.1	149.6	99.2	94.5	639.8	71.6	89.2	83.9	80.1	105.8	72.7	131.5	85.9	63.3	186.7	108.4	69.5	86.2	61.2	70.8	103.2	166.4	259.9	199.5	79.9	104.5	155.1	155.8	131.6	103.1	107.3	68.8	164.2	89.8	104.5	56.5	90.4	273.6	340.4	107.1	205.0	160.2	270.8	92.7	114.9	1051.8	83.2	98.9	175.5	487.7	138.7	130.4	111.0	122.5	68.1	43.0	30.7	25.6	31.6	31.4	54.8	71.8	73.3	59.0	48.0
FA(22:3)	9.0	10.5	NA	5.1	9.4	3.8	10.6	9.3	5.3	NA	4.9	8.6	2.9	1.5	3.5	0.6	0.9	NA	1.6	3.3	22.2	13.2	19.3	23.7	12.4	12.1	4.3	524.0	6.8	2.6	4.0	1.7	3.8	5.9	34.9	3.8	NA	13.3	6.8	4.4	7.3	3.8	5.7	10.7	14.3	24.2	15.1	6.1	8.7	13.0	6.9	10.9	9.0	6.9	8.9	14.2	5.7	8.6	5.1	7.3	31.8	28.2	9.4	19.0	12.1	29.3	1.9	22.9	746.0	NA	4.0	14.5	292.6	2.4	5.5	3.1	2.5	NA	5.6	4.7	14.0	7.5	3.9	6.8	7.8	7.3	5.1	4.7
FA(22:4)	435.8	612.5	274.1	1268.4	851.5	257.2	1844.4	1105.5	863.6	281.2	1120.2	1198.6	632.0	975.0	675.8	1216.5	1227.5	677.0	1489.8	1839.8	2282.9	2843.4	1876.0	2637.5	2113.5	1280.3	754.0	1599.3	926.0	1737.9	1623.0	1398.5	2347.5	1416.4	1562.6	2005.7	1103.1	3143.8	2187.0	2119.8	2301.4	1108.2	1157.9	1675.4	1394.2	1997.2	2262.2	842.6	2020.6	2040.4	1652.2	1398.0	1600.8	2259.6	1773.7	2415.7	1506.5	1398.5	1125.6	1244.8	2552.2	2044.8	1216.3	1033.9	1249.4	2733.5	1083.6	1571.7	1237.7	1327.9	2254.1	2182.3	1880.6	1497.8	1158.8	1076.1	1757.2	921.0	1272.2	1338.9	1000.1	398.7	885.0	1447.1	1843.8	1251.6	1512.0	1894.7
FA(22:5 N3)	156.3	229.2	91.1	409.1	270.9	121.3	501.2	242.6	298.7	83.5	301.7	287.8	192.1	316.5	253.0	279.6	326.3	377.1	499.6	901.7	972.5	870.9	688.2	743.0	488.6	441.9	238.1	853.7	211.7	788.6	430.0	464.3	742.8	851.2	743.6	635.4	344.1	665.2	664.6	795.0	880.3	458.4	706.7	1385.7	593.8	726.9	1011.8	380.5	799.6	673.8	950.1	897.0	686.2	915.3	492.6	935.7	753.0	690.0	724.7	515.5	1031.4	931.4	664.3	688.4	565.3	1485.6	587.0	405.1	823.5	521.1	907.1	547.5	612.2	539.5	364.6	407.1	451.8	594.7	743.5	528.5	393.3	245.0	438.6	796.3	451.1	383.6	423.4	840.7
FA(22:5 N6)	246.8	557.3	249.7	1012.2	794.2	192.1	1115.9	809.7	687.7	261.2	1242.7	775.5	612.6	678.1	1106.5	1046.5	1311.6	694.7	1693.3	1948.9	2431.1	3021.7	1819.9	1933.0	1367.0	959.9	689.7	1418.4	957.7	1515.0	1706.3	1466.8	2551.2	1691.6	1346.9	2696.9	952.8	3068.7	2208.1	1946.9	3039.9	1024.5	1427.2	1588.8	1011.1	1296.1	1797.2	976.5	2018.5	1884.8	2043.9	2015.5	1497.7	2138.6	1413.2	2735.6	1687.7	1392.7	1048.0	1263.8	3049.6	2367.5	1061.5	1058.4	1212.7	2117.7	1069.4	1554.7	1211.3	1256.3	2074.9	1183.7	1351.6	1433.6	1087.0	1108.2	2200.1	1459.3	1002.4	1041.3	747.2	482.2	1041.8	1331.3	1654.1	1202.7	1413.3	2060.9
FA(22:6)	606.1	1050.1	313.7	1669.5	1570.9	485.7	1792.9	1006.2	877.2	363.1	1343.8	1002.5	1585.6	1423.8	2593.7	1599.5	1588.1	1666.7	1446.2	3940.4	5474.3	3273.7	2352.7	3155.6	1499.0	1296.3	936.4	1872.7	1236.7	2927.7	2100.7	2604.1	3602.0	3244.1	3980.1	3049.6	1326.5	3683.9	2993.8	2681.2	3356.3	1459.9	3928.5	3962.8	1672.4	2577.3	4367.2	1610.6	3200.9	2667.3	5634.6	6130.1	2035.2	3891.8	2302.7	5769.3	2708.8	3233.0	2254.4	2015.5	4388.3	3322.6	2113.5	2149.7	1908.8	4757.5	2467.7	1989.1	1815.8	2235.0	2715.2	1728.2	2250.5	2421.1	1671.6	1591.3	3077.1	4176.7	2941.1	2976.1	2047.1	944.5	1260.9	2747.4	1618.3	1947.4	1454.4	2701.2
FA(23:0)	13.7	6.2	4.8	7.0	7.9	2.5	7.4	7.0	5.3	3.8	4.2	3.1	2.1	7.2	9.4	6.7	3.1	5.0	20.4	27.2	31.1	52.2	9.9	7.0	6.4	2.4	17.8	122.5	15.9	12.8	7.0	12.8	8.2	13.3	33.6	18.6	3.1	8.7	10.7	7.8	13.1	8.1	13.6	13.3	2.2	51.5	5.4	8.4	12.2	15.1	17.4	12.7	16.3	13.3	28.9	10.8	12.8	8.6	10.4	15.6	4.5	49.0	11.7	59.5	13.9	7.4	35.3	37.1	220.7	NA	4.7	15.4	93.0	11.3	11.3	5.1	20.4	14.5	16.0	51.3	155.4	25.6	15.3	27.6	17.7	16.6	13.6	15.8
FA(24:0)	76.2	28.5	17.3	30.1	52.9	10.4	30.5	32.6	24.4	15.8	30.6	25.5	21.6	31.9	45.2	32.2	21.0	31.2	207.9	123.9	197.5	297.5	53.4	42.0	77.4	43.1	117.4	182.1	87.9	77.4	36.1	66.8	37.9	75.4	91.7	72.8	44.7	48.1	42.4	7.8	25.1	7.6	22.8	21.0	NA	82.9	15.9	9.2	12.5	40.5	95.7	67.6	72.8	54.1	100.9	36.2	45.8	23.1	10.9	43.5	NA	143.7	21.1	58.0	78.8	17.8	140.7	120.0	277.4	38.5	55.6	74.4	163.7	81.8	62.8	46.9	136.4	77.8	51.9	153.9	311.6	80.9	66.1	88.2	97.0	73.3	61.8	77.7
FA(24:1)	30.7	27.1	18.3	35.8	46.7	12.9	52.0	31.0	28.6	23.1	23.1	37.4	16.7	19.8	31.8	31.9	22.4	23.1	40.8	105.0	183.5	85.8	36.0	44.7	75.3	48.1	107.5	79.9	50.3	56.0	45.5	49.2	71.4	46.5	67.8	57.7	36.9	76.0	46.9	46.7	55.6	29.8	41.8	39.7	54.3	59.3	70.9	63.0	90.1	71.7	67.3	55.6	144.5	49.5	54.6	51.2	40.5	43.8	78.6	41.5	50.2	42.4	43.1	57.8	125.9	62.1	69.4	56.7	99.5	42.6	75.9	77.3	101.0	54.7	43.0	42.7	48.2	51.6	57.8	208.8	82.6	63.2	61.5	67.5	84.9	62.2	79.1	86.9
FA(26:0)	35.8	5.1	0.8	13.0	12.3	NA	5.3	13.6	7.6	8.2	2.3	5.4	1.6	9.0	14.9	7.7	2.2	8.8	61.0	54.2	36.7	90.2	NA	6.5	1.0	1.9	34.2	67.8	31.1	20.3	1.2	9.9	7.0	4.1	8.3	12.4	NA	3.7	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	5.8	23.0	90.2	NA	NA	NA	61.4	NA	NA	NA	12.6	NA	19.9	171.0	358.3	30.6	25.4	20.1	32.0	23.0	20.0	40.8
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name
6k PGF1a
TxB2
PGE2
TXB1
dhk PGF2a
dhk PGD2
20oh PGE2
PGFM
tetranor 12-HETE
12-HHTrE
11-HETE
PGA2
16 HDoHE
LTE4
5-HETE
9-HOTrE
5-HETrE
15-HETE
13-HODE
13-HOTrE
15-HETrE
8-HETE
10 HDoHE
8-HETrE
12-HETE
12-HEPE
14 HDoHE
11 HDoHE
9-HODE
HXB3
9-oxoODE
13-oxoODE
18-HETE
16-HETE
19,20 DiHDPA
9,10 EpOME
12,13 EpOME
5,6-diHETrE
8,9-diHETrE
11,12-diHETrE
14,15-diHETrE
9,10 diHOME
12,13 diHOME
20cooh AA
2,3 dinor TXB2
FA(14:0)
FA(15:0)
FA(16:0)
FA(16:1)
FA(17:0)
FA(17:1)
FA(18:0)
FA(18:1)
FA(18:2)
FA(18:3 N3)
FA(18:3 N6)
FA(18:4)
FA(20:0)
FA(20:1)
FA(20:2)
FA(20:3 N3)
FA(20:3 N6)
FA(20:3 N9)
FA(20:4)
FA(20:5)
FA(22:0)
FA(22:1)
FA(22:2)
FA(22:3)
FA(22:4)
FA(22:5 N3)
FA(22:5 N6)
FA(22:6)
FA(23:0)
FA(24:0)
FA(24:1)
FA(26:0)
METABOLITES_END
#END