#METABOLOMICS WORKBENCH houyuanlong2020_20201209_041438 DATATRACK_ID:2344 STUDY_ID:ST001620 ANALYSIS_ID:AN002655 PROJECT_ID:PR001041 VERSION 1 CREATED_ON December 11, 2020, 9:53 am #PROJECT PR:PROJECT_TITLE Dietary composition analysis studies PR:PROJECT_TYPE Untargeted metabolomics analysis with two diets PR:PROJECT_SUMMARY Dietary patterns and psychosocial factors, ubiquitous part of modern lifestyle, PR:PROJECT_SUMMARY critically shape the gut microbiota and human health. However, it remains PR:PROJECT_SUMMARY obscure how dietary and psychosocial inputs coordinately modulate the gut PR:PROJECT_SUMMARY microbiota and host impact. Here, we show that dietary raffinose metabolism to PR:PROJECT_SUMMARY fructose couples stress-induced gut microbial remodeling to intestinal stem PR:PROJECT_SUMMARY cells (ISC) renewal and epithelial homeostasis. Chow diet (CD) and purified diet PR:PROJECT_SUMMARY (PD) confer distinct vulnerability to gut epithelial injury, microbial PR:PROJECT_SUMMARY alternation and ISC dysfunction in chronically restrained mice. CD preferably PR:PROJECT_SUMMARY enriches Lactobacillus reuteri, and its colonization is sufficient to rescue PR:PROJECT_SUMMARY stress-triggered epithelial injury. PR:INSTITUTE China Pharmaceutical University PR:DEPARTMENT School of Medicine PR:LABORATORY metabonomics PR:LAST_NAME Yunalong PR:FIRST_NAME Hou PR:ADDRESS Nanjing, Jiangsu PR:EMAIL jian2103@163.com PR:PHONE 18851105337 #STUDY ST:STUDY_TITLE Dietary composition analysis of chow diet and purified diet using untargeted ST:STUDY_TITLE metabonomics ST:STUDY_SUMMARY Dietary patterns and psychosocial factors, ubiquitous part of modern lifestyle, ST:STUDY_SUMMARY critically shape the gut microbiota and human health. However, it remains ST:STUDY_SUMMARY obscure how dietary and psychosocial inputs coordinately modulate the gut ST:STUDY_SUMMARY microbiota and host impact. Here, we show that dietary raffinose metabolism to ST:STUDY_SUMMARY fructose couples stress-induced gut microbial remodeling to intestinal stem ST:STUDY_SUMMARY cells (ISC) renewal and epithelial homeostasis. Chow diet (CD) and purified diet ST:STUDY_SUMMARY (PD) confer distinct vulnerability to gut epithelial injury, microbial ST:STUDY_SUMMARY alternation and ISC dysfunction in chronically restrained mice. CD preferably ST:STUDY_SUMMARY enriches Lactobacillus reuteri, and its colonization is sufficient to rescue ST:STUDY_SUMMARY stress-triggered epithelial injury. ST:INSTITUTE China Pharmaceutical University ST:DEPARTMENT School of Medicine ST:LABORATORY metabonomics ST:LAST_NAME Yuanlong ST:FIRST_NAME Hou ST:ADDRESS Nanjing, Jiangsu ST:EMAIL jian2103@163.com ST:PHONE 86-18851105337 #SUBJECT SU:SUBJECT_TYPE Food item #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - PD1 Diet:Purified RAW_FILE_NAME=PD1 SUBJECT_SAMPLE_FACTORS - PD2 Diet:Purified RAW_FILE_NAME=PD2 SUBJECT_SAMPLE_FACTORS - PD3 Diet:Purified RAW_FILE_NAME=PD3 SUBJECT_SAMPLE_FACTORS - PD4 Diet:Purified RAW_FILE_NAME=PD4 SUBJECT_SAMPLE_FACTORS - CD1 Diet:Chow RAW_FILE_NAME=CD1 SUBJECT_SAMPLE_FACTORS - CD2 Diet:Chow RAW_FILE_NAME=CD2 SUBJECT_SAMPLE_FACTORS - CD3 Diet:Chow RAW_FILE_NAME=CD3 #COLLECTION CO:COLLECTION_SUMMARY Purified diet and chow diet CO:SAMPLE_TYPE Diet CO:STORAGE_CONDITIONS 4℃ #TREATMENT TR:TREATMENT_SUMMARY Diet pellets (30 mg) were weighted by adding 400 µL of methanol (pre-cooled at TR:TREATMENT_SUMMARY -20℃), vortexed for 60 s, and then centrifuged for 10 min at 13,000 g, 4℃. TR:TREATMENT_SUMMARY The supernatant was evaporated to dryness under vacuum, reconstituted with 150 TR:TREATMENT_SUMMARY μL of 2-chlorophenyalanine (4ppm) methanol aqueous solution. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Diet pellets (30 mg) come from lab SP:PROCESSING_STORAGE_CONDITIONS 4℃ SP:EXTRACT_STORAGE 4℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME UltiMate 3000 CH:COLUMN_NAME Waters Acquity UPLC HSS T3 (150×2.1 mm,1.8 µm) #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Q Exactive Focus MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE UNSPECIFIED MS:MS_COMMENTS Data dependent acquisition The Progenesis QI MetaboAnalyst 3.0 #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS peak area MS_METABOLITE_DATA_START Samples PD1 PD2 PD3 PD4 CD1 CD2 CD3 Factors Diet:Purified Diet:Purified Diet:Purified Diet:Purified Diet:Chow Diet:Chow Diet:Chow Alanine 3738351.177 4107228.975 3297035.981 4215511.609 47561055.41 47150449.19 44168781.33 Valerolactam 10572517.86 9452215.072 10639758.29 10071073.82 459256213.7 456358058.6 445241753.8 2-Ketobutyrate 2835833.256 1228233.467 3572553.483 3372488.827 15050121.17 16774622.88 18175033.75 Cadaverine 504672.3525 452697.8617 488199.6649 617791.5369 19799623.44 21196971.16 23497347.28 Gamma-Aminobutyrate 8393844.568 7962231.293 8262938.906 7582228.926 81125551.06 80041169.47 72273282.94 3-Hydroxybutyrate 180015144.2 171821964.3 195805564.4 170185394.9 241594119.1 237387324.8 237437037.1 Benzaldehyde 1916033.188 1796364.323 1786544.244 1740931.046 11365625.5 11535317.12 11668767.67 Pyrrole-2-Carboxylate 46148301.53 46131191.02 48532972.62 42973446.77 36703299.17 37535400.91 36875004.67 Cytosine 2272583.497 2140945.566 1985489.836 1974970.083 58690632.07 56944298.15 55460404.63 Pantolactone 1936375.584 1811088.838 1933854.233 2031960.995 6176766.033 6745474.019 6750175.001 Valine 6722347.31 1209524.048 1467997.046 1219850.115 45926257.59 44624092.82 45270445.17 Fumarate 3091292.307 2781903.828 3012013.697 2893644.792 18195495.2 17141390.45 17785319.06 Indole 41843385.39 40295171.91 43581797.06 40933065.72 488738581.4 506533218.2 508030673.1 Niacinamide 57323284.5 33732407.49 7890248.612 8936853.621 4256698120 3760904093 3456707759 Thymine 48856325.57 8011894.51 46593947.1 7895646.688 128223735.3 126953482.7 124433217.4 Pyroglutamate 16505943.51 16048475.98 18442871.4 15733873.03 783682960.4 731409644 758096381.1 Quinoline 16395408.74 24578848.01 9774006.57 19875068.08 28119862.35 33369392.62 32172338.71 Pipecolate 17838303.09 11102918.96 11483917.63 13777313.54 2273885102 2291653849 1602440470 Leucine 72642593.59 28604772.12 17619819.66 48607148.72 206046582.2 298693965.9 289401869 Cinnamate 2089444.46 2077121.648 2065600.211 1834315.785 26548186.4 24581413.26 24730737.56 4-Hydroxy-D-Proline 9460114.425 10615851.59 11862202.47 9609508.413 6311712.52 4641765.781 4312303.757 N-Acetyl-L-Alanine 2811374.955 2746175.632 2682514.152 2566526.011 11181938.52 11781052.28 10490474.74 Isoleucine 71788325.23 81641149.8 59746671.1 122824647.7 2102230001 1995144161 1988269663 Malate 655284.3273 564353.0709 499591.5853 556664.1453 27954690.04 27579221.36 31154849.46 Adenine 108751108.7 115529485.2 105002031.2 106904123.2 246226341 259624244.4 204492669.6 Threonate 7380628.963 7828704.331 6402994.877 7102813.955 149464676.7 181673226.5 168140459 Urocanate 3521760.597 4363044.502 3957324.748 5162677.261 5990322.252 6802906.003 5626597.676 Hypoxanthine 9024286.014 8665449.689 8798006.196 9930382.995 1301867742 1165946255 1174883656 2-Methoxyhydroquinone 6278608.642 5968127.117 1627874.742 1479579.455 18586645.4 18148443.68 17823614.67 Caprylate 3569605.467 3639728.214 3833184.402 3662206.339 1773561.731 1190923.27 1183962.703 Coumarin 28464526.18 29364393.07 33569056.1 29675459.7 527101644.6 483742002.2 553963886.6 Glutamate 3166125.015 4514682.567 3036720.484 3361319.604 3658004340 3820384108 2761821457 Lysine 4360303.166 3451052.01 4318364.826 3723268.778 117102988.9 116667826 89322553.5 Ribose 24998684.54 32023103.31 37005960.44 23979361.42 144793670.7 118537380.1 98950109.25 Methionine 1160898.4 1201612.93 1451206.997 1276247.083 65667629.91 76153669.23 73036299.04 Guanine 4237756.033 4234101.554 4761603.568 4302172.645 63070388.08 72490237.51 66353454.32 Lyxose 60797111.85 64138150.26 61406297.27 58136927.96 43940222.07 45543971.8 44896378.2 Arabitol 3542946.152 3321101.606 3086274.553 3749602.951 68833324.39 73649134.73 70420424.34 Xanthine 14222998.13 15544133.44 16243581.29 14762851.34 522842286.2 480155000.4 494484903.3 Gentisate 60.29200215 60.29200215 60.29200215 60.29200215 258321094.3 276742801.6 65997648.03 Oxoadipate 138059257.6 139951597.8 111471619.9 154348975.7 91605979.03 59389926.99 71646439.43 Tryptamine 6536332.495 6470254.666 6675788.934 6494557.621 34288884.49 34645002.01 33413727.99 Carnitine 12943149.61 13023682.69 13293973.64 13234883.5 58275282.24 59349122.3 52687196.42 Pterin 13105146.42 14248703.89 16349110.45 14403532.45 6879515.06 7016439.807 6922277.637 7-Methylguanine 172086.6304 156319.377 187481.8327 217537.2394 3867111.476 3802639.977 3794755.973 Beta-Homomethionine 1162489.326 1104800.585 5559120.148 1123000.363 18923357.71 20850211.95 18592494.63 Coumarate 8912113.374 9261330.303 10036673.89 9095491.382 7198996.001 7469340.423 7621757.267 Methionine S-Oxide 15146313.23 8162029.001 28034906.78 11570937.86 212711253.8 196674745.4 246040268.6 Phenylalanine 190714908.5 197199123.4 204171993.4 196803406.3 3098768897 2888155627 2886758738 Vanillate 2715751.383 2571501.244 3034873.961 2711326.722 9047976.84 8986605.197 9281045.54 4-Hydroxyphenylglycine 602499.2479 1185946.87 1921310.794 1225966.113 11628908.99 12922640.62 15072060.76 Stachyose 66475308.77 56106385.25 70654751.81 64645949.06 136962579.6 98642021.93 107652508.7 Quinaldate 1943094.702 1337998.155 1607383.079 1541496.592 4527414.998 3931208.461 3493063.386 N-Formyl-L-Methionine 411747.4814 375741.5149 308566.342 391800.9367 4649448.514 5158689.399 5046063.895 Guanidinosuccinate 52446553.23 21784077.76 14852871.84 29956293.93 105181862.4 102930150.1 102026604.3 Coniferyl Aldehyde 1584879.132 1564929.584 1650837.242 1443209.007 3067067.614 3638252.924 3597957.162 Theophylline 14209363.21 12843105.39 13184510.11 12969522.7 7950943.884 1918299.075 1874013.395 Tyrosine 17383952.38 16187984.47 18383441.9 16967206.26 177995517.8 179668803.1 168799473.6 Sorbitol 297026868 164683604.8 219554817.8 262855072.8 913353616.2 993514887 907491720.2 Sebacate 3530483.989 2253051.096 2406387.587 2126310.149 6936735.632 11117931.71 10216004.51 Indoleacrylate 365175.2615 304530.7331 289521.8834 321948.1542 10788490.55 11430759.26 10906696.11 Azelaic acid 22383843.62 24583850.42 22203905.61 24959056.48 85615740.21 84634075.62 83024247.99 Alpha-Acetyllysine 80333351.54 83131406.86 91506486.4 83283447.26 17968905212 18531686515 18542487513 Glycylleucine 1322673.997 1561324.219 1082332.338 1190817.348 46113458.25 43238428.56 40444326.43 N-Acetylglutamate 17760612.16 20267361.68 24633249.59 18976317.61 11703855.14 11482966.47 11921447.02 N-Acetyl-DL-Methionine 658771.8917 821832.9789 151446.8679 940615.1564 20494286.68 17929896.02 19277392.14 Daidzin 263582.0268 247055.9071 234615.8994 2403.396568 832577.8493 594589.2556 584831.942 Citrate 1369684825 1430630733 1500360580 1456216580 424545372.3 318429884.9 379555088.4 Phenylacetylglycine 5531173.17 5661916.073 5096500.327 5885321.371 20937475.79 17963330.48 19868880.1 Ferulate 5453169.969 5147177.827 5854033.303 5320100.243 71539318.92 71431914.61 65454671.33 Gluconate 379609.339 440364.769 338838.4115 387103.6208 190248196.1 229161988.3 203960443.9 Gulonate 466329.0863 498470.5615 501093.3769 609324.4229 2620443.547 2880523.686 2258337.949 Mannonate 516444.2179 527328.2034 707215.5761 504053.3769 1041837.582 959874.0126 936744.4253 Dopa 14944423.29 15304719.57 21418424.88 15972014.07 1944309.434 6113568.149 6006136.627 Ala-Ile 373997.9665 411835.241 195739.6998 523360.9292 6346175.171 7110190.095 6116684.304 Maltotriose 95313988.87 74906620.27 110008205.2 91903490.73 266757084.4 255797737.8 257320561.7 Leucyl-Alanine 2068572.318 2296566.841 2420555.642 2219353.155 13475747.6 11589698.99 13823111.87 Tryptophan 67107.63133 46000.05766 55098.99218 111209.3157 25024912.47 25517250.46 25164776.64 Kynurenine 32060051.38 40170010.86 32547759.41 37898981.94 15885834.48 15851401.92 16861395.05 Sinapate 3578277.454 3713859.607 3273895.193 3558501.665 10359433.93 9419276.399 10047870.94 Astragalin 31015.85688 1918237.978 2599.218857 1881380.722 4935676.328 3764039.816 3244725.889 Myristoleate 19446464.46 21804953.43 19069160.33 21457777.74 6006743.17 957712.1798 4784783.595 Dodecanedioate 115027.0343 103259.4288 103568.815 113645.0048 3839342.818 3697296.558 4111757.982 Myristic acid 8387078.863 8724236.77 9063625.984 8496805.648 6927132.021 7145829.876 6930174.62 Butyryl-L-Carnitine 1200678.429 1271381.131 1223670.179 1241855.671 8128544.028 7583699.412 7953078.804 N-Lactoyl-Phenylalanine 722236.0418 1006710.693 950973.7308 943692.9746 12281555.19 11409692.09 11205785.48 Uridine 498567.5283 443610.0136 450468.02 474968.3142 131872982.4 119271011.3 117904011.3 4-Oxododecanedioic acid 1041138.686 1087074.571 992758.409 1096173.09 9643837.803 9237292.804 9265129.846 3-Hydroxy-Tetradecanoic acid 49615633.74 51800655.11 49799388.35 50438561.35 107545320.4 95903197.79 94238219.69 Cytidine 349526.6102 433785.3493 375677.8057 573145.405 48172939.42 45987713.22 48473049.77 N-Acetyl-DL-Tryptophan 161732.4479 185017.1037 165157.9701 172494.8542 6501214.317 6548811.79 6251824.095 Phe-Pro 4882699.64 4942001.151 4853386.95 5009536.571 74374798.47 71046439.37 68588887.05 Glycitin 24491509.32 4453.806534 23242209.12 2887.17312 97066971.02 67883445.93 59705207.14 2-Deoxyadenosine 2527178.028 2515578.259 2534312.551 2453862.667 27877484.53 27265963.9 25352722.5 5,7-Dihydroxyflavone 1268600.446 1070137.848 1149156.226 922050.2986 107645722 68272821.02 77534355.78 Palmitoleic acid 22360632.08 20850533.14 24716099.81 19282976.85 1033864742 852299629.5 811832404.6 Naringenin 639089.2627 4785668.063 3872878.81 2940205.04 27715768.21 30940340.61 32894426.85 Glu-Leu 816608.9279 751195.7392 742054.0932 808743.8307 32933838.71 26587151.42 27820718.6 Thiamine 6501175.378 5355097.665 3108232.682 6193506.402 20183576.82 19187875.44 24421045.2 Valyl-Phenylalanine 2759381.918 3008304.627 3333915.371 2958321.582 18871127.29 15849580.13 18315842.72 2-Deoxyguanosine 588229.9354 637492.1684 779918.1699 694037.1205 12957823.18 13087157.61 11871817.07 Adenosine 59104.76361 79558.91772 76052.24543 75140.94798 13783898.5 12478153.2 11051674.83 Hesperetin 1366157.283 12449047.29 12227767.72 11561773.84 16290845.67 23129270.89 22945904.41 Inosine 13127411.59 13646226.49 15137360.8 13964167.9 1032210697 876869454.7 885305520.2 12-OPDA 2567936.882 1675895.335 2169677.67 2641088.41 19225861.21 21338876.7 20215474.18 Stearidonic acid 72460159.47 83374924.07 78056912.75 80582037.08 924589078 862289959.6 868857004.8 Linoleic acid 48045611.41 49922728.53 56108159.94 49492570.06 74108801.94 82397654.84 80263938.47 Guanosine 143921.5328 11977.1195 15984.32994 59024.98625 19492270.3 17734764.86 18126586.28 Hexadecanedioic acid 10815775.09 10084735.12 9880561.931 6610822.683 18654980.72 19116943.53 28768991.08 13-L-Hydroperoxylinoleic acid 335238933.4 363799508.5 343429516.9 358222086.2 6644440177 6503057708 6546701778 Gingerol 1469600.23 3532586.721 2490570.082 1975676.156 14075395.85 12653052.01 14158198.58 13S-Hydroxyoctadecadienoic acid 9371241.057 8557641.276 17200167.59 8432513.835 1157392434 1059127509 1122151136 9,10-Epoxyoctadecenoic acid 1423880255 1516234890 1467502678 1496553631 11942847690 12047634250 12011722979 Nonadecanoic acid 1395992347 1651005331 1624445569 1601347274 2089329772 2070011921 2051346212 2-O-Methylguanosine 221232.0591 206319.059 108637.4156 147522.9998 14312770.18 12981589.09 12503980.5 Arachidonic acid 122295.2138 133236.625 182030.4783 164039.6516 3622053.841 3078362.964 2890439.83 dCMP 3613232.534 3133327.427 3381381.377 3042395.124 2254395.226 2443975.356 2563846.092 Ribose-1,5-Bisphosphate 28465589.15 24515986.91 26008649.86 39552909.62 14294912.06 15673989.73 13484934.74 9,10-DHOME 193186887.6 202611826.6 201909483.7 217465680 3135732061 3261326923 3162441152 Malvidin 1537146.334 1800957.576 1804019.677 2003452.061 10392399.2 19784164.47 29801594.23 15-Deoxy-D-12,14-PGJ2 4063912.228 4384562.897 4225291.815 3814959.027 8138915.06 7498221.075 10281875.2 Alpha-Linolenoyl Ethanolamide 1186598.178 516378.102 543654.8414 3557113.606 65367719.35 64077115.36 65946740.95 Cellobiose 14114.03585 8154.49118 16342.97193 9701027.599 24896751.04 23524504.64 25030999 Cyclic AMP 1019398.9 1176078.391 1124491.013 1113352.411 11454154.3 10207083.9 10618144.57 3-AMP 339601.0039 1097370.848 954636.8568 307673.8741 14838611.36 12661737.85 12922853.01 5-O-Beta-D-Glucosylpyridoxine 973.1869568 896.2745847 2357.632803 1392.629396 6625051.437 6123802.196 5907727.262 5,6-DiHETE 257067.0615 274761.348 241064.6178 281512.9638 127530445.6 120463026.7 128312358 5,6-DHET 1137860.89 1329299.675 1283619.315 2016535.415 148627015.9 130646281.7 135723042.1 Trehalose 598696478.5 546761950.2 898804295.7 868622399.1 171277906.9 209528734.4 160953979.8 MG(18:2/0:0/0:0) 3934237.902 4693024.569 5470858.932 4218710.698 47467776.35 26704944.84 40233699.31 2-Linoleoyl Glycerol 30771252.04 20411693.14 2181734.201 19878934.05 1257796497 1237972600 1066413197 Rosmarinate 3415.307294 1126.214346 1123.93335 1543.545126 6446582.584 5624955.003 5764339.953 N-Oleoyl-Serine 781177.2727 676936.5773 813407.7998 708708.6372 26143338.5 21577617.74 21691585.08 N-Arachidonoyl-Alanine 67924.22222 134157.7246 144270.6875 123806.6614 20686765.04 21456458.31 20250606.33 S-Adenosylhomocysteine 2253.367392 2099.226329 3133.290834 1332.637297 3153366.739 2961036.151 2786501.397 Acetyl-Maltose 27901.64695 244577.0258 28967.2605 216568.831 4981903.325 4262796.154 4230313.837 Deoxycholic acid 45096695.43 39883780.49 33503138.68 40617882.22 20413835.47 20873920 20786052.57 Cosmosiin 1104138.611 1159203.111 1339334.297 895.3126968 4035439.028 3193056.554 2256161.555 Oleanoic acid 29450.07838 19126.23406 22813.05568 37816.46161 12072189.73 9932993.453 12168287.86 Folic acid 8732868.965 8252387.89 7019440.999 9453627.17 425131.0734 999566.5676 725986.5619 PC(14:0/0:0) 47337245.29 60753819.77 58161455.34 52824141.85 570659605.9 573047141.5 522884084.6 Raffinose 1721080.344 1730532.037 1895449.419 2018421.616 32330461.34 43123269.88 33146094.79 1-Heptadecanoyl-sn-Glycero-3-Phosphocholine 6802609.405 2321944.293 1466619.082 2506326.448 15565130.72 23248156.16 23757485.64 6-Malonylgenistin 1202203.146 1434033.518 3127.441414 1252905.091 5397204.988 3674027.645 3579945.805 Syringaresinol O-Beta-D-Glucoside 1114289.639 1094744.949 1129460.628 1090179.722 2088439.068 2270503.646 2477705.026 Maltotetraose 10957927.58 16361920.43 9220976.836 13070700.13 542135.6085 8605313.767 2610862.984 Maltohexaose 24264316.13 36033985.93 21405868.14 24027413.67 51699.29307 150068.6749 87742.45286 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Alanine Valerolactam 2-Ketobutyrate Cadaverine Gamma-Aminobutyrate 3-Hydroxybutyrate Benzaldehyde Pyrrole-2-Carboxylate Cytosine Pantolactone Valine Fumarate Indole Niacinamide Thymine Pyroglutamate Quinoline Pipecolate Leucine Cinnamate 4-Hydroxy-D-Proline N-Acetyl-L-Alanine Isoleucine Malate Adenine Threonate Urocanate Hypoxanthine 2-Methoxyhydroquinone Caprylate Coumarin Glutamate Lysine Ribose Methionine Guanine Lyxose Arabitol Xanthine Gentisate Oxoadipate Tryptamine Carnitine Pterin 7-Methylguanine Beta-Homomethionine Coumarate Methionine S-Oxide Phenylalanine Vanillate 4-Hydroxyphenylglycine Stachyose Quinaldate N-Formyl-L-Methionine Guanidinosuccinate Coniferyl Aldehyde Theophylline Tyrosine Sorbitol Sebacate Indoleacrylate Azelaic acid Alpha-Acetyllysine Glycylleucine N-Acetylglutamate N-Acetyl-DL-Methionine Daidzin Citrate Phenylacetylglycine Ferulate Gluconate Gulonate Mannonate Dopa Ala-Ile Maltotriose Leucyl-Alanine Tryptophan Kynurenine Sinapate Astragalin Myristoleate Dodecanedioate Myristic acid Butyryl-L-Carnitine N-Lactoyl-Phenylalanine Uridine 4-Oxododecanedioic acid 3-Hydroxy-Tetradecanoic acid Cytidine N-Acetyl-DL-Tryptophan Phe-Pro Glycitin 2-Deoxyadenosine 5,7-Dihydroxyflavone Palmitoleic acid Naringenin Glu-Leu Thiamine Valyl-Phenylalanine 2-Deoxyguanosine Adenosine Hesperetin Inosine 12-OPDA Stearidonic acid Linoleic acid Guanosine Hexadecanedioic acid 13-L-Hydroperoxylinoleic acid Gingerol 13S-Hydroxyoctadecadienoic acid 9,10-Epoxyoctadecenoic acid Nonadecanoic acid 2-O-Methylguanosine Arachidonic acid dCMP Ribose-1,5-Bisphosphate 9,10-DHOME Malvidin 15-Deoxy-D-12,14-PGJ2 Alpha-Linolenoyl Ethanolamide Cellobiose Cyclic AMP 3-AMP 5-O-Beta-D-Glucosylpyridoxine 5,6-DiHETE 5,6-DHET Trehalose MG(18:2/0:0/0:0) 2-Linoleoyl Glycerol Rosmarinate N-Oleoyl-Serine N-Arachidonoyl-Alanine S-Adenosylhomocysteine Acetyl-Maltose Deoxycholic acid Cosmosiin Oleanoic acid Folic acid PC(14:0/0:0) Raffinose 1-Heptadecanoyl-sn-Glycero-3-Phosphocholine 6-Malonylgenistin Syringaresinol O-Beta-D-Glucoside Maltotetraose Maltohexaose METABOLITES_END #END