#METABOLOMICS WORKBENCH kcontrep_20210726_225458 DATATRACK_ID:2771 STUDY_ID:ST001889 ANALYSIS_ID:AN003064 PROJECT_ID:PR001190
VERSION             	1
CREATED_ON             	August 2, 2021, 11:09 am
#PROJECT
PR:PROJECT_TITLE                 	Preeclampsia and plasma metabolomics
PR:PROJECT_SUMMARY               	Longitudinal untargeted plasma metabolomics of pregnant women with preeclampsia
PR:INSTITUTE                     	Stanford University
PR:LAST_NAME                     	Contrepois
PR:FIRST_NAME                    	Kevin
PR:ADDRESS                       	300 Pasteur Dr
PR:EMAIL                         	kcontrep@stanford.edu
PR:PHONE                         	6506664538
#STUDY
ST:STUDY_TITLE                   	Multiomics Longitudinal Modeling of Preeclamptic Pregnancies (part I)
ST:STUDY_SUMMARY                 	Preeclampsia is a complex disease of pregnancy whose physiopathology remains
ST:STUDY_SUMMARY                 	unclear and that poses a threat to both mothers and infants. Specific complex
ST:STUDY_SUMMARY                 	changes in women's physiology precede a diagnosis of preeclampsia. Understanding
ST:STUDY_SUMMARY                 	multiple aspects of such a complex changes at different levels of biology can be
ST:STUDY_SUMMARY                 	enabled by simultaneous application of multiple assays. We developed prediction
ST:STUDY_SUMMARY                 	models for preeclampsia risk by analyzing six omics datasets from a longitudinal
ST:STUDY_SUMMARY                 	cohort of pregnant women. A machine learning-based multiomics model had high
ST:STUDY_SUMMARY                 	accuracy (area under the receiver operating characteristics curve (AUC) of 0.94,
ST:STUDY_SUMMARY                 	95% confidence intervals (CI): [0.90, 0.99]). A prediction model using only ten
ST:STUDY_SUMMARY                 	urine metabolites provided an accuracy of the whole metabolomic dataset and was
ST:STUDY_SUMMARY                 	validated using an independent cohort of 16 women (AUC=0.87, 95% CI: [0.76,
ST:STUDY_SUMMARY                 	0.99]). Integration with clinical variables further improved prediction accuracy
ST:STUDY_SUMMARY                 	of the urine metabolome model (AUC=0.90, 95% CI: [0.80, 0.99], urine metabolome,
ST:STUDY_SUMMARY                 	validated). We identified several biological pathways to be associated with
ST:STUDY_SUMMARY                 	preeclampsia. The findings derived from models were integrated with immune
ST:STUDY_SUMMARY                 	system cytometry data, confirming known physiological alterations associated
ST:STUDY_SUMMARY                 	with preeclampsia and suggesting novel associations between the immune and
ST:STUDY_SUMMARY                 	proteomic dynamics. While further validation in larger populations is necessary,
ST:STUDY_SUMMARY                 	these encouraging results will serve as a basis for a simple, early diagnostic
ST:STUDY_SUMMARY                 	test for preeclampsia.
ST:INSTITUTE                     	Stanford University
ST:LAST_NAME                     	Contrepois
ST:FIRST_NAME                    	Kevin
ST:ADDRESS                       	300 Pasteur Dr
ST:EMAIL                         	kcontrep@stanford.edu
ST:PHONE                         	6506664538
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	10056	1005608055	Gestational Age At Sampling:5 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005608055; RAW_FILE_NAME=nHILIC_1005608055; RAW_FILE_NAME=pRPLC_1005608055; RAW_FILE_NAME=nRPLC_1005608055
SUBJECT_SAMPLE_FACTORS           	10056	1005608155	Gestational Age At Sampling:15 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005608155; RAW_FILE_NAME=nHILIC_1005608155; RAW_FILE_NAME=pRPLC_1005608155; RAW_FILE_NAME=nRPLC_1005608155
SUBJECT_SAMPLE_FACTORS           	10056	1005608265	Gestational Age At Sampling:26 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005608265; RAW_FILE_NAME=nHILIC_1005608265; RAW_FILE_NAME=pRPLC_1005608265; RAW_FILE_NAME=nRPLC_1005608265
SUBJECT_SAMPLE_FACTORS           	10056	1005608365	Gestational Age At Sampling:36 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005608365; RAW_FILE_NAME=nHILIC_1005608365; RAW_FILE_NAME=pRPLC_1005608365; RAW_FILE_NAME=nRPLC_1005608365
SUBJECT_SAMPLE_FACTORS           	10104	1010408165	Gestational Age At Sampling:16 | Gestational Age At Delivery:32 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1010408165; RAW_FILE_NAME=nHILIC_1010408165; RAW_FILE_NAME=pRPLC_1010408165; RAW_FILE_NAME=nRPLC_1010408165
SUBJECT_SAMPLE_FACTORS           	10104	1010408235	Gestational Age At Sampling:23 | Gestational Age At Delivery:32 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1010408235; RAW_FILE_NAME=nHILIC_1010408235; RAW_FILE_NAME=pRPLC_1010408235; RAW_FILE_NAME=nRPLC_1010408235
SUBJECT_SAMPLE_FACTORS           	10104	1010408325	Gestational Age At Sampling:32 | Gestational Age At Delivery:32 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1010408325; RAW_FILE_NAME=nHILIC_1010408325; RAW_FILE_NAME=pRPLC_1010408325; RAW_FILE_NAME=nRPLC_1010408325
SUBJECT_SAMPLE_FACTORS           	10112	1011208155	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1011208155; RAW_FILE_NAME=nHILIC_1011208155; RAW_FILE_NAME=pRPLC_1011208155; RAW_FILE_NAME=nRPLC_1011208155
SUBJECT_SAMPLE_FACTORS           	10112	1011208265	Gestational Age At Sampling:26 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1011208265; RAW_FILE_NAME=nHILIC_1011208265; RAW_FILE_NAME=pRPLC_1011208265; RAW_FILE_NAME=nRPLC_1011208265
SUBJECT_SAMPLE_FACTORS           	10112	1011208395	Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1011208395; RAW_FILE_NAME=nHILIC_1011208395; RAW_FILE_NAME=pRPLC_1011208395; RAW_FILE_NAME=nRPLC_1011208395
SUBJECT_SAMPLE_FACTORS           	10502	1050208105	Gestational Age At Sampling:10 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050208105; RAW_FILE_NAME=nHILIC_1050208105; RAW_FILE_NAME=pRPLC_1050208105; RAW_FILE_NAME=nRPLC_1050208105
SUBJECT_SAMPLE_FACTORS           	10502	1050208255	Gestational Age At Sampling:25 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050208255; RAW_FILE_NAME=nHILIC_1050208255; RAW_FILE_NAME=pRPLC_1050208255; RAW_FILE_NAME=nRPLC_1050208255
SUBJECT_SAMPLE_FACTORS           	10502	1050208415	Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050208415; RAW_FILE_NAME=nHILIC_1050208415; RAW_FILE_NAME=pRPLC_1050208415; RAW_FILE_NAME=nRPLC_1050208415
SUBJECT_SAMPLE_FACTORS           	10503	1050308185	Gestational Age At Sampling:18 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050308185; RAW_FILE_NAME=nHILIC_1050308185; RAW_FILE_NAME=pRPLC_1050308185; RAW_FILE_NAME=nRPLC_1050308185
SUBJECT_SAMPLE_FACTORS           	10503	1050308275	Gestational Age At Sampling:27 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050308275; RAW_FILE_NAME=nHILIC_1050308275; RAW_FILE_NAME=pRPLC_1050308275; RAW_FILE_NAME=nRPLC_1050308275
SUBJECT_SAMPLE_FACTORS           	10503	1050308415	Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050308415; RAW_FILE_NAME=nHILIC_1050308415; RAW_FILE_NAME=pRPLC_1050308415; RAW_FILE_NAME=nRPLC_1050308415
SUBJECT_SAMPLE_FACTORS           	10505	1050508085	Gestational Age At Sampling:8 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050508085; RAW_FILE_NAME=nHILIC_1050508085; RAW_FILE_NAME=pRPLC_1050508085; RAW_FILE_NAME=nRPLC_1050508085
SUBJECT_SAMPLE_FACTORS           	10505	1050508175	Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050508175; RAW_FILE_NAME=nHILIC_1050508175; RAW_FILE_NAME=pRPLC_1050508175; RAW_FILE_NAME=nRPLC_1050508175
SUBJECT_SAMPLE_FACTORS           	10505	1050508264	Gestational Age At Sampling:26 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050508264; RAW_FILE_NAME=nHILIC_1050508264; RAW_FILE_NAME=pRPLC_1050508264; RAW_FILE_NAME=nRPLC_1050508264
SUBJECT_SAMPLE_FACTORS           	10505	1050508385	Gestational Age At Sampling:38 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050508385; RAW_FILE_NAME=nHILIC_1050508385; RAW_FILE_NAME=pRPLC_1050508385; RAW_FILE_NAME=nRPLC_1050508385
SUBJECT_SAMPLE_FACTORS           	10515	1051508115	Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051508115; RAW_FILE_NAME=nHILIC_1051508115; RAW_FILE_NAME=pRPLC_1051508115; RAW_FILE_NAME=nRPLC_1051508115
SUBJECT_SAMPLE_FACTORS           	10515	1051508155	Gestational Age At Sampling:15 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051508155; RAW_FILE_NAME=nHILIC_1051508155; RAW_FILE_NAME=pRPLC_1051508155; RAW_FILE_NAME=nRPLC_1051508155
SUBJECT_SAMPLE_FACTORS           	10515	1051508254	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051508254; RAW_FILE_NAME=nHILIC_1051508254; RAW_FILE_NAME=pRPLC_1051508254; RAW_FILE_NAME=nRPLC_1051508254
SUBJECT_SAMPLE_FACTORS           	10515	1051508405	Gestational Age At Sampling:40 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051508405; RAW_FILE_NAME=nHILIC_1051508405; RAW_FILE_NAME=pRPLC_1051508405; RAW_FILE_NAME=nRPLC_1051508405
SUBJECT_SAMPLE_FACTORS           	10523	1052308085	Gestational Age At Sampling:8 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052308085; RAW_FILE_NAME=nHILIC_1052308085; RAW_FILE_NAME=pRPLC_1052308085; RAW_FILE_NAME=nRPLC_1052308085
SUBJECT_SAMPLE_FACTORS           	10523	1052308155	Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052308155; RAW_FILE_NAME=nHILIC_1052308155; RAW_FILE_NAME=pRPLC_1052308155; RAW_FILE_NAME=nRPLC_1052308155
SUBJECT_SAMPLE_FACTORS           	10523	1052308284	Gestational Age At Sampling:28 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052308284; RAW_FILE_NAME=nHILIC_1052308284; RAW_FILE_NAME=pRPLC_1052308284; RAW_FILE_NAME=nRPLC_1052308284
SUBJECT_SAMPLE_FACTORS           	10523	1052308415	Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052308415; RAW_FILE_NAME=nHILIC_1052308415; RAW_FILE_NAME=pRPLC_1052308415; RAW_FILE_NAME=nRPLC_1052308415
SUBJECT_SAMPLE_FACTORS           	10524	1052408115	Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052408115; RAW_FILE_NAME=nHILIC_1052408115; RAW_FILE_NAME=pRPLC_1052408115; RAW_FILE_NAME=nRPLC_1052408115
SUBJECT_SAMPLE_FACTORS           	10524	1052408184	Gestational Age At Sampling:18 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052408184; RAW_FILE_NAME=nHILIC_1052408184; RAW_FILE_NAME=pRPLC_1052408184; RAW_FILE_NAME=nRPLC_1052408184
SUBJECT_SAMPLE_FACTORS           	10524	1052408265	Gestational Age At Sampling:26 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052408265; RAW_FILE_NAME=nHILIC_1052408265; RAW_FILE_NAME=pRPLC_1052408265; RAW_FILE_NAME=nRPLC_1052408265
SUBJECT_SAMPLE_FACTORS           	10524	1052408385	Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052408385; RAW_FILE_NAME=nHILIC_1052408385; RAW_FILE_NAME=pRPLC_1052408385; RAW_FILE_NAME=nRPLC_1052408385
SUBJECT_SAMPLE_FACTORS           	10528	1052808105	Gestational Age At Sampling:10 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052808105; RAW_FILE_NAME=nHILIC_1052808105; RAW_FILE_NAME=pRPLC_1052808105; RAW_FILE_NAME=nRPLC_1052808105
SUBJECT_SAMPLE_FACTORS           	10528	1052808285	Gestational Age At Sampling:28 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052808285; RAW_FILE_NAME=nHILIC_1052808285; RAW_FILE_NAME=pRPLC_1052808285; RAW_FILE_NAME=nRPLC_1052808285
SUBJECT_SAMPLE_FACTORS           	10528	1052808385	Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052808385; RAW_FILE_NAME=nHILIC_1052808385; RAW_FILE_NAME=pRPLC_1052808385; RAW_FILE_NAME=nRPLC_1052808385
SUBJECT_SAMPLE_FACTORS           	10530	1053008155	Gestational Age At Sampling:15 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053008155; RAW_FILE_NAME=nHILIC_1053008155; RAW_FILE_NAME=pRPLC_1053008155; RAW_FILE_NAME=nRPLC_1053008155
SUBJECT_SAMPLE_FACTORS           	10530	1053008335	Gestational Age At Sampling:33 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053008335; RAW_FILE_NAME=nHILIC_1053008335; RAW_FILE_NAME=pRPLC_1053008335; RAW_FILE_NAME=nRPLC_1053008335
SUBJECT_SAMPLE_FACTORS           	10530	1053008365	Gestational Age At Sampling:36 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053008365; RAW_FILE_NAME=nHILIC_1053008365; RAW_FILE_NAME=pRPLC_1053008365; RAW_FILE_NAME=nRPLC_1053008365
SUBJECT_SAMPLE_FACTORS           	10533	1053308175	Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053308175; RAW_FILE_NAME=nHILIC_1053308175; RAW_FILE_NAME=pRPLC_1053308175; RAW_FILE_NAME=nRPLC_1053308175
SUBJECT_SAMPLE_FACTORS           	10533	1053308265	Gestational Age At Sampling:26 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053308265; RAW_FILE_NAME=nHILIC_1053308265; RAW_FILE_NAME=pRPLC_1053308265; RAW_FILE_NAME=nRPLC_1053308265
SUBJECT_SAMPLE_FACTORS           	10533	1053308375	Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053308375; RAW_FILE_NAME=nHILIC_1053308375; RAW_FILE_NAME=pRPLC_1053308375; RAW_FILE_NAME=nRPLC_1053308375
SUBJECT_SAMPLE_FACTORS           	10535	1053508115	Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053508115; RAW_FILE_NAME=nHILIC_1053508115; RAW_FILE_NAME=pRPLC_1053508115; RAW_FILE_NAME=nRPLC_1053508115
SUBJECT_SAMPLE_FACTORS           	10535	1053508165	Gestational Age At Sampling:16 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053508165; RAW_FILE_NAME=nHILIC_1053508165; RAW_FILE_NAME=pRPLC_1053508165; RAW_FILE_NAME=nRPLC_1053508165
SUBJECT_SAMPLE_FACTORS           	10535	1053508275	Gestational Age At Sampling:27 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053508275; RAW_FILE_NAME=nHILIC_1053508275; RAW_FILE_NAME=pRPLC_1053508275; RAW_FILE_NAME=nRPLC_1053508275
SUBJECT_SAMPLE_FACTORS           	10538	1053808085	Gestational Age At Sampling:8 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053808085; RAW_FILE_NAME=nHILIC_1053808085; RAW_FILE_NAME=pRPLC_1053808085; RAW_FILE_NAME=nRPLC_1053808085
SUBJECT_SAMPLE_FACTORS           	10538	1053808165	Gestational Age At Sampling:16 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053808165; RAW_FILE_NAME=nHILIC_1053808165; RAW_FILE_NAME=pRPLC_1053808165; RAW_FILE_NAME=nRPLC_1053808165
SUBJECT_SAMPLE_FACTORS           	10538	1053808284	Gestational Age At Sampling:28 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053808284; RAW_FILE_NAME=nHILIC_1053808284; RAW_FILE_NAME=pRPLC_1053808284; RAW_FILE_NAME=nRPLC_1053808284
SUBJECT_SAMPLE_FACTORS           	10538	1053808395	Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053808395; RAW_FILE_NAME=nHILIC_1053808395; RAW_FILE_NAME=pRPLC_1053808395; RAW_FILE_NAME=nRPLC_1053808395
SUBJECT_SAMPLE_FACTORS           	10541	1054108095	Gestational Age At Sampling:9 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054108095; RAW_FILE_NAME=nHILIC_1054108095; RAW_FILE_NAME=pRPLC_1054108095; RAW_FILE_NAME=nRPLC_1054108095
SUBJECT_SAMPLE_FACTORS           	10541	1054108155	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054108155; RAW_FILE_NAME=nHILIC_1054108155; RAW_FILE_NAME=pRPLC_1054108155; RAW_FILE_NAME=nRPLC_1054108155
SUBJECT_SAMPLE_FACTORS           	10541	1054108274	Gestational Age At Sampling:27 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054108274; RAW_FILE_NAME=nHILIC_1054108274; RAW_FILE_NAME=pRPLC_1054108274; RAW_FILE_NAME=nRPLC_1054108274
SUBJECT_SAMPLE_FACTORS           	10541	1054108394	Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054108394; RAW_FILE_NAME=nHILIC_1054108394; RAW_FILE_NAME=pRPLC_1054108394; RAW_FILE_NAME=nRPLC_1054108394
SUBJECT_SAMPLE_FACTORS           	10546	1054608095	Gestational Age At Sampling:9 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054608095; RAW_FILE_NAME=nHILIC_1054608095; RAW_FILE_NAME=pRPLC_1054608095; RAW_FILE_NAME=nRPLC_1054608095
SUBJECT_SAMPLE_FACTORS           	10546	1054608155	Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054608155; RAW_FILE_NAME=nHILIC_1054608155; RAW_FILE_NAME=pRPLC_1054608155; RAW_FILE_NAME=nRPLC_1054608155
SUBJECT_SAMPLE_FACTORS           	10546	1054608295	Gestational Age At Sampling:29 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054608295; RAW_FILE_NAME=nHILIC_1054608295; RAW_FILE_NAME=pRPLC_1054608295; RAW_FILE_NAME=nRPLC_1054608295
SUBJECT_SAMPLE_FACTORS           	10546	1054608415	Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054608415; RAW_FILE_NAME=nHILIC_1054608415; RAW_FILE_NAME=pRPLC_1054608415; RAW_FILE_NAME=nRPLC_1054608415
SUBJECT_SAMPLE_FACTORS           	10547	1054708105	Gestational Age At Sampling:10 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054708105; RAW_FILE_NAME=nHILIC_1054708105; RAW_FILE_NAME=pRPLC_1054708105; RAW_FILE_NAME=nRPLC_1054708105
SUBJECT_SAMPLE_FACTORS           	10547	1054708155	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054708155; RAW_FILE_NAME=nHILIC_1054708155; RAW_FILE_NAME=pRPLC_1054708155; RAW_FILE_NAME=nRPLC_1054708155
SUBJECT_SAMPLE_FACTORS           	10547	1054708245	Gestational Age At Sampling:24 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054708245; RAW_FILE_NAME=nHILIC_1054708245; RAW_FILE_NAME=pRPLC_1054708245; RAW_FILE_NAME=nRPLC_1054708245
SUBJECT_SAMPLE_FACTORS           	10547	1054708395	Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054708395; RAW_FILE_NAME=nHILIC_1054708395; RAW_FILE_NAME=pRPLC_1054708395; RAW_FILE_NAME=nRPLC_1054708395
SUBJECT_SAMPLE_FACTORS           	10548	1054808185	Gestational Age At Sampling:18 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054808185; RAW_FILE_NAME=nHILIC_1054808185; RAW_FILE_NAME=pRPLC_1054808185; RAW_FILE_NAME=nRPLC_1054808185
SUBJECT_SAMPLE_FACTORS           	10548	1054808255	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054808255; RAW_FILE_NAME=nHILIC_1054808255; RAW_FILE_NAME=pRPLC_1054808255; RAW_FILE_NAME=nRPLC_1054808255
SUBJECT_SAMPLE_FACTORS           	10551	1055108105	Gestational Age At Sampling:10 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1055108105; RAW_FILE_NAME=nHILIC_1055108105; RAW_FILE_NAME=pRPLC_1055108105; RAW_FILE_NAME=nRPLC_1055108105
SUBJECT_SAMPLE_FACTORS           	10551	1055108155	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1055108155; RAW_FILE_NAME=nHILIC_1055108155; RAW_FILE_NAME=pRPLC_1055108155; RAW_FILE_NAME=nRPLC_1055108155
SUBJECT_SAMPLE_FACTORS           	10551	1055108265	Gestational Age At Sampling:26 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1055108265; RAW_FILE_NAME=nHILIC_1055108265; RAW_FILE_NAME=pRPLC_1055108265; RAW_FILE_NAME=nRPLC_1055108265
SUBJECT_SAMPLE_FACTORS           	10553	1055308175	Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055308175; RAW_FILE_NAME=nHILIC_1055308175; RAW_FILE_NAME=pRPLC_1055308175; RAW_FILE_NAME=nRPLC_1055308175
SUBJECT_SAMPLE_FACTORS           	10553	1055308245	Gestational Age At Sampling:24 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055308245; RAW_FILE_NAME=nHILIC_1055308245; RAW_FILE_NAME=pRPLC_1055308245; RAW_FILE_NAME=nRPLC_1055308245
SUBJECT_SAMPLE_FACTORS           	10553	1055308375	Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055308375; RAW_FILE_NAME=nHILIC_1055308375; RAW_FILE_NAME=pRPLC_1055308375; RAW_FILE_NAME=nRPLC_1055308375
SUBJECT_SAMPLE_FACTORS           	10558	1055808085	Gestational Age At Sampling:8 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055808085; RAW_FILE_NAME=nHILIC_1055808085; RAW_FILE_NAME=pRPLC_1055808085; RAW_FILE_NAME=nRPLC_1055808085
SUBJECT_SAMPLE_FACTORS           	10558	1055808155	Gestational Age At Sampling:15 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055808155; RAW_FILE_NAME=nHILIC_1055808155; RAW_FILE_NAME=pRPLC_1055808155; RAW_FILE_NAME=nRPLC_1055808155
SUBJECT_SAMPLE_FACTORS           	10558	1055808255	Gestational Age At Sampling:25 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055808255; RAW_FILE_NAME=nHILIC_1055808255; RAW_FILE_NAME=pRPLC_1055808255; RAW_FILE_NAME=nRPLC_1055808255
SUBJECT_SAMPLE_FACTORS           	10558	1055808384	Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055808384; RAW_FILE_NAME=nHILIC_1055808384; RAW_FILE_NAME=pRPLC_1055808384; RAW_FILE_NAME=nRPLC_1055808384
SUBJECT_SAMPLE_FACTORS           	10561	1056108115	Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1056108115; RAW_FILE_NAME=nHILIC_1056108115; RAW_FILE_NAME=pRPLC_1056108115; RAW_FILE_NAME=nRPLC_1056108115
SUBJECT_SAMPLE_FACTORS           	10561	1056108255	Gestational Age At Sampling:25 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1056108255; RAW_FILE_NAME=nHILIC_1056108255; RAW_FILE_NAME=pRPLC_1056108255; RAW_FILE_NAME=nRPLC_1056108255
SUBJECT_SAMPLE_FACTORS           	10601	1060108113	Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060108113; RAW_FILE_NAME=nHILIC_1060108113; RAW_FILE_NAME=pRPLC_1060108113; RAW_FILE_NAME=nRPLC_1060108113
SUBJECT_SAMPLE_FACTORS           	10601	1060108163	Gestational Age At Sampling:16 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060108163; RAW_FILE_NAME=nHILIC_1060108163; RAW_FILE_NAME=pRPLC_1060108163; RAW_FILE_NAME=nRPLC_1060108163
SUBJECT_SAMPLE_FACTORS           	10601	1060108273	Gestational Age At Sampling:27 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060108273; RAW_FILE_NAME=nHILIC_1060108273; RAW_FILE_NAME=pRPLC_1060108273; RAW_FILE_NAME=nRPLC_1060108273
SUBJECT_SAMPLE_FACTORS           	10601	1060108474	Gestational Age At Sampling:47 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060108474; RAW_FILE_NAME=nHILIC_1060108474; RAW_FILE_NAME=pRPLC_1060108474; RAW_FILE_NAME=nRPLC_1060108474
SUBJECT_SAMPLE_FACTORS           	10634	1063408114	Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063408114; RAW_FILE_NAME=nHILIC_1063408114; RAW_FILE_NAME=pRPLC_1063408114; RAW_FILE_NAME=nRPLC_1063408114
SUBJECT_SAMPLE_FACTORS           	10634	1063408164	Gestational Age At Sampling:16 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063408164; RAW_FILE_NAME=nHILIC_1063408164; RAW_FILE_NAME=pRPLC_1063408164; RAW_FILE_NAME=nRPLC_1063408164
SUBJECT_SAMPLE_FACTORS           	10634	1063408244	Gestational Age At Sampling:24 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063408244; RAW_FILE_NAME=nHILIC_1063408244; RAW_FILE_NAME=pRPLC_1063408244; RAW_FILE_NAME=nRPLC_1063408244
SUBJECT_SAMPLE_FACTORS           	10634	1063408465	Gestational Age At Sampling:46 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063408465; RAW_FILE_NAME=nHILIC_1063408465; RAW_FILE_NAME=pRPLC_1063408465; RAW_FILE_NAME=nRPLC_1063408465
SUBJECT_SAMPLE_FACTORS           	10639	1063908114	Gestational Age At Sampling:11 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063908114; RAW_FILE_NAME=nHILIC_1063908114; RAW_FILE_NAME=pRPLC_1063908114; RAW_FILE_NAME=nRPLC_1063908114
SUBJECT_SAMPLE_FACTORS           	10639	1063908164	Gestational Age At Sampling:16 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063908164; RAW_FILE_NAME=nHILIC_1063908164; RAW_FILE_NAME=pRPLC_1063908164; RAW_FILE_NAME=nRPLC_1063908164
SUBJECT_SAMPLE_FACTORS           	10639	1063908274	Gestational Age At Sampling:27 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063908274; RAW_FILE_NAME=nHILIC_1063908274; RAW_FILE_NAME=pRPLC_1063908274; RAW_FILE_NAME=nRPLC_1063908274
SUBJECT_SAMPLE_FACTORS           	10639	1063908465	Gestational Age At Sampling:46 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063908465; RAW_FILE_NAME=nHILIC_1063908465; RAW_FILE_NAME=pRPLC_1063908465; RAW_FILE_NAME=nRPLC_1063908465
SUBJECT_SAMPLE_FACTORS           	10712	1071208134	Gestational Age At Sampling:13 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071208134; RAW_FILE_NAME=nHILIC_1071208134; RAW_FILE_NAME=pRPLC_1071208134; RAW_FILE_NAME=nRPLC_1071208134
SUBJECT_SAMPLE_FACTORS           	10712	1071208165	Gestational Age At Sampling:16 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071208165; RAW_FILE_NAME=nHILIC_1071208165; RAW_FILE_NAME=pRPLC_1071208165; RAW_FILE_NAME=nRPLC_1071208165
SUBJECT_SAMPLE_FACTORS           	10712	1071208252	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071208252; RAW_FILE_NAME=nHILIC_1071208252; RAW_FILE_NAME=pRPLC_1071208252; RAW_FILE_NAME=nRPLC_1071208252
SUBJECT_SAMPLE_FACTORS           	10713	1071308113	Gestational Age At Sampling:11 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071308113; RAW_FILE_NAME=nHILIC_1071308113; RAW_FILE_NAME=pRPLC_1071308113; RAW_FILE_NAME=nRPLC_1071308113
SUBJECT_SAMPLE_FACTORS           	10713	1071308174	Gestational Age At Sampling:17 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071308174; RAW_FILE_NAME=nHILIC_1071308174; RAW_FILE_NAME=pRPLC_1071308174; RAW_FILE_NAME=nRPLC_1071308174
SUBJECT_SAMPLE_FACTORS           	10713	1071308262	Gestational Age At Sampling:26 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071308262; RAW_FILE_NAME=nHILIC_1071308262; RAW_FILE_NAME=pRPLC_1071308262; RAW_FILE_NAME=nRPLC_1071308262
SUBJECT_SAMPLE_FACTORS           	10713	1071308485	Gestational Age At Sampling:48 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071308485; RAW_FILE_NAME=nHILIC_1071308485; RAW_FILE_NAME=pRPLC_1071308485; RAW_FILE_NAME=nRPLC_1071308485
SUBJECT_SAMPLE_FACTORS           	10721	1072108114	Gestational Age At Sampling:11 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072108114; RAW_FILE_NAME=nHILIC_1072108114; RAW_FILE_NAME=pRPLC_1072108114; RAW_FILE_NAME=nRPLC_1072108114
SUBJECT_SAMPLE_FACTORS           	10721	1072108182	Gestational Age At Sampling:18 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072108182; RAW_FILE_NAME=nHILIC_1072108182; RAW_FILE_NAME=pRPLC_1072108182; RAW_FILE_NAME=nRPLC_1072108182
SUBJECT_SAMPLE_FACTORS           	10721	1072108274	Gestational Age At Sampling:27 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072108274; RAW_FILE_NAME=nHILIC_1072108274; RAW_FILE_NAME=pRPLC_1072108274; RAW_FILE_NAME=nRPLC_1072108274
SUBJECT_SAMPLE_FACTORS           	10721	1072108455	Gestational Age At Sampling:45 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072108455; RAW_FILE_NAME=nHILIC_1072108455; RAW_FILE_NAME=pRPLC_1072108455; RAW_FILE_NAME=nRPLC_1072108455
SUBJECT_SAMPLE_FACTORS           	10722	1072208124	Gestational Age At Sampling:12 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072208124; RAW_FILE_NAME=nHILIC_1072208124; RAW_FILE_NAME=pRPLC_1072208124; RAW_FILE_NAME=nRPLC_1072208124
SUBJECT_SAMPLE_FACTORS           	10722	1072208174	Gestational Age At Sampling:17 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072208174; RAW_FILE_NAME=nHILIC_1072208174; RAW_FILE_NAME=pRPLC_1072208174; RAW_FILE_NAME=nRPLC_1072208174
SUBJECT_SAMPLE_FACTORS           	10722	1072208254	Gestational Age At Sampling:25 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072208254; RAW_FILE_NAME=nHILIC_1072208254; RAW_FILE_NAME=pRPLC_1072208254; RAW_FILE_NAME=nRPLC_1072208254
SUBJECT_SAMPLE_FACTORS           	10722	1072208365	Gestational Age At Sampling:36 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072208365; RAW_FILE_NAME=nHILIC_1072208365; RAW_FILE_NAME=pRPLC_1072208365; RAW_FILE_NAME=nRPLC_1072208365
SUBJECT_SAMPLE_FACTORS           	10723	1072308135	Gestational Age At Sampling:13 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072308135; RAW_FILE_NAME=nHILIC_1072308135; RAW_FILE_NAME=pRPLC_1072308135; RAW_FILE_NAME=nRPLC_1072308135
SUBJECT_SAMPLE_FACTORS           	10723	1072308175	Gestational Age At Sampling:17 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072308175; RAW_FILE_NAME=nHILIC_1072308175; RAW_FILE_NAME=pRPLC_1072308175; RAW_FILE_NAME=nRPLC_1072308175
SUBJECT_SAMPLE_FACTORS           	10723	1072308255	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072308255; RAW_FILE_NAME=nHILIC_1072308255; RAW_FILE_NAME=pRPLC_1072308255; RAW_FILE_NAME=nRPLC_1072308255
SUBJECT_SAMPLE_FACTORS           	10723	1072308455	Gestational Age At Sampling:45 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072308455; RAW_FILE_NAME=nHILIC_1072308455; RAW_FILE_NAME=pRPLC_1072308455; RAW_FILE_NAME=nRPLC_1072308455
SUBJECT_SAMPLE_FACTORS           	10727	1072708114	Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072708114; RAW_FILE_NAME=nHILIC_1072708114; RAW_FILE_NAME=pRPLC_1072708114; RAW_FILE_NAME=nRPLC_1072708114
SUBJECT_SAMPLE_FACTORS           	10727	1072708164	Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072708164; RAW_FILE_NAME=nHILIC_1072708164; RAW_FILE_NAME=pRPLC_1072708164; RAW_FILE_NAME=nRPLC_1072708164
SUBJECT_SAMPLE_FACTORS           	10727	1072708274	Gestational Age At Sampling:27 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072708274; RAW_FILE_NAME=nHILIC_1072708274; RAW_FILE_NAME=pRPLC_1072708274; RAW_FILE_NAME=nRPLC_1072708274
SUBJECT_SAMPLE_FACTORS           	10732	1073208114	Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073208114; RAW_FILE_NAME=nHILIC_1073208114; RAW_FILE_NAME=pRPLC_1073208114; RAW_FILE_NAME=nRPLC_1073208114
SUBJECT_SAMPLE_FACTORS           	10732	1073208184	Gestational Age At Sampling:18 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073208184; RAW_FILE_NAME=nHILIC_1073208184; RAW_FILE_NAME=pRPLC_1073208184; RAW_FILE_NAME=nRPLC_1073208184
SUBJECT_SAMPLE_FACTORS           	10732	1073208242	Gestational Age At Sampling:24 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073208242; RAW_FILE_NAME=nHILIC_1073208242; RAW_FILE_NAME=pRPLC_1073208242; RAW_FILE_NAME=nRPLC_1073208242
SUBJECT_SAMPLE_FACTORS           	10732	1073208465	Gestational Age At Sampling:46 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073208465; RAW_FILE_NAME=nHILIC_1073208465; RAW_FILE_NAME=pRPLC_1073208465; RAW_FILE_NAME=nRPLC_1073208465
SUBJECT_SAMPLE_FACTORS           	10733	1073308124	Gestational Age At Sampling:12 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073308124; RAW_FILE_NAME=nHILIC_1073308124; RAW_FILE_NAME=pRPLC_1073308124; RAW_FILE_NAME=nRPLC_1073308124
SUBJECT_SAMPLE_FACTORS           	10733	1073308155	Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073308155; RAW_FILE_NAME=nHILIC_1073308155; RAW_FILE_NAME=pRPLC_1073308155; RAW_FILE_NAME=nRPLC_1073308155
SUBJECT_SAMPLE_FACTORS           	10733	1073308262	Gestational Age At Sampling:26 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073308262; RAW_FILE_NAME=nHILIC_1073308262; RAW_FILE_NAME=pRPLC_1073308262; RAW_FILE_NAME=nRPLC_1073308262
SUBJECT_SAMPLE_FACTORS           	10733	1073308485	Gestational Age At Sampling:48 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073308485; RAW_FILE_NAME=nHILIC_1073308485; RAW_FILE_NAME=pRPLC_1073308485; RAW_FILE_NAME=nRPLC_1073308485
SUBJECT_SAMPLE_FACTORS           	10736	1073608134	Gestational Age At Sampling:13 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073608134; RAW_FILE_NAME=nHILIC_1073608134; RAW_FILE_NAME=pRPLC_1073608134; RAW_FILE_NAME=nRPLC_1073608134
SUBJECT_SAMPLE_FACTORS           	10736	1073608174	Gestational Age At Sampling:17 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073608174; RAW_FILE_NAME=nHILIC_1073608174; RAW_FILE_NAME=pRPLC_1073608174; RAW_FILE_NAME=nRPLC_1073608174
SUBJECT_SAMPLE_FACTORS           	10736	1073608254	Gestational Age At Sampling:25 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073608254; RAW_FILE_NAME=nHILIC_1073608254; RAW_FILE_NAME=pRPLC_1073608254; RAW_FILE_NAME=nRPLC_1073608254
SUBJECT_SAMPLE_FACTORS           	10736	1073608465	Gestational Age At Sampling:46 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073608465; RAW_FILE_NAME=nHILIC_1073608465; RAW_FILE_NAME=pRPLC_1073608465; RAW_FILE_NAME=nRPLC_1073608465
SUBJECT_SAMPLE_FACTORS           	10803	1080308134	Gestational Age At Sampling:13 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080308134; RAW_FILE_NAME=nHILIC_1080308134; RAW_FILE_NAME=pRPLC_1080308134; RAW_FILE_NAME=nRPLC_1080308134
SUBJECT_SAMPLE_FACTORS           	10803	1080308164	Gestational Age At Sampling:16 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080308164; RAW_FILE_NAME=nHILIC_1080308164; RAW_FILE_NAME=pRPLC_1080308164; RAW_FILE_NAME=nRPLC_1080308164
SUBJECT_SAMPLE_FACTORS           	10803	1080308264	Gestational Age At Sampling:26 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080308264; RAW_FILE_NAME=nHILIC_1080308264; RAW_FILE_NAME=pRPLC_1080308264; RAW_FILE_NAME=nRPLC_1080308264
SUBJECT_SAMPLE_FACTORS           	10803	1080308529	Gestational Age At Sampling:52 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080308529; RAW_FILE_NAME=nHILIC_1080308529; RAW_FILE_NAME=pRPLC_1080308529; RAW_FILE_NAME=nRPLC_1080308529
SUBJECT_SAMPLE_FACTORS           	10804	1080408154	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1080408154; RAW_FILE_NAME=nHILIC_1080408154; RAW_FILE_NAME=pRPLC_1080408154; RAW_FILE_NAME=nRPLC_1080408154
SUBJECT_SAMPLE_FACTORS           	10804	1080408282	Gestational Age At Sampling:28 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1080408282; RAW_FILE_NAME=nHILIC_1080408282; RAW_FILE_NAME=pRPLC_1080408282; RAW_FILE_NAME=nRPLC_1080408282
SUBJECT_SAMPLE_FACTORS           	10804	1080408465	Gestational Age At Sampling:46 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1080408465; RAW_FILE_NAME=nHILIC_1080408465; RAW_FILE_NAME=pRPLC_1080408465; RAW_FILE_NAME=nRPLC_1080408465
SUBJECT_SAMPLE_FACTORS           	10809	1080908114	Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080908114; RAW_FILE_NAME=nHILIC_1080908114; RAW_FILE_NAME=pRPLC_1080908114; RAW_FILE_NAME=nRPLC_1080908114
SUBJECT_SAMPLE_FACTORS           	10809	1080908184	Gestational Age At Sampling:18 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080908184; RAW_FILE_NAME=nHILIC_1080908184; RAW_FILE_NAME=pRPLC_1080908184; RAW_FILE_NAME=nRPLC_1080908184
SUBJECT_SAMPLE_FACTORS           	10809	1080908244	Gestational Age At Sampling:24 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080908244; RAW_FILE_NAME=nHILIC_1080908244; RAW_FILE_NAME=pRPLC_1080908244; RAW_FILE_NAME=nRPLC_1080908244
SUBJECT_SAMPLE_FACTORS           	10816	1081608114	Gestational Age At Sampling:11 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081608114; RAW_FILE_NAME=nHILIC_1081608114; RAW_FILE_NAME=pRPLC_1081608114; RAW_FILE_NAME=nRPLC_1081608114
SUBJECT_SAMPLE_FACTORS           	10816	1081608164	Gestational Age At Sampling:16 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081608164; RAW_FILE_NAME=nHILIC_1081608164; RAW_FILE_NAME=pRPLC_1081608164; RAW_FILE_NAME=nRPLC_1081608164
SUBJECT_SAMPLE_FACTORS           	10816	1081608248	Gestational Age At Sampling:24 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081608248; RAW_FILE_NAME=nHILIC_1081608248; RAW_FILE_NAME=pRPLC_1081608248; RAW_FILE_NAME=nRPLC_1081608248
SUBJECT_SAMPLE_FACTORS           	10816	1081608489	Gestational Age At Sampling:48 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081608489; RAW_FILE_NAME=nHILIC_1081608489; RAW_FILE_NAME=pRPLC_1081608489; RAW_FILE_NAME=nRPLC_1081608489
SUBJECT_SAMPLE_FACTORS           	10822	1082208139	Gestational Age At Sampling:13 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082208139; RAW_FILE_NAME=nHILIC_1082208139; RAW_FILE_NAME=pRPLC_1082208139; RAW_FILE_NAME=nRPLC_1082208139
SUBJECT_SAMPLE_FACTORS           	10822	1082208169	Gestational Age At Sampling:16 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082208169; RAW_FILE_NAME=nHILIC_1082208169; RAW_FILE_NAME=pRPLC_1082208169; RAW_FILE_NAME=nRPLC_1082208169
SUBJECT_SAMPLE_FACTORS           	10822	1082208289	Gestational Age At Sampling:28 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082208289; RAW_FILE_NAME=nHILIC_1082208289; RAW_FILE_NAME=pRPLC_1082208289; RAW_FILE_NAME=nRPLC_1082208289
SUBJECT_SAMPLE_FACTORS           	10822	1082208459	Gestational Age At Sampling:45 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082208459; RAW_FILE_NAME=nHILIC_1082208459; RAW_FILE_NAME=pRPLC_1082208459; RAW_FILE_NAME=nRPLC_1082208459
SUBJECT_SAMPLE_FACTORS           	10824	1082408129	Gestational Age At Sampling:12 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082408129; RAW_FILE_NAME=nHILIC_1082408129; RAW_FILE_NAME=pRPLC_1082408129; RAW_FILE_NAME=nRPLC_1082408129
SUBJECT_SAMPLE_FACTORS           	10824	1082408169	Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082408169; RAW_FILE_NAME=nHILIC_1082408169; RAW_FILE_NAME=pRPLC_1082408169; RAW_FILE_NAME=nRPLC_1082408169
SUBJECT_SAMPLE_FACTORS           	10824	1082408289	Gestational Age At Sampling:28 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082408289; RAW_FILE_NAME=nHILIC_1082408289; RAW_FILE_NAME=pRPLC_1082408289; RAW_FILE_NAME=nRPLC_1082408289
SUBJECT_SAMPLE_FACTORS           	10833	1083308119	Gestational Age At Sampling:11 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083308119; RAW_FILE_NAME=nHILIC_1083308119; RAW_FILE_NAME=pRPLC_1083308119; RAW_FILE_NAME=nRPLC_1083308119
SUBJECT_SAMPLE_FACTORS           	10833	1083308159	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083308159; RAW_FILE_NAME=nHILIC_1083308159; RAW_FILE_NAME=pRPLC_1083308159; RAW_FILE_NAME=nRPLC_1083308159
SUBJECT_SAMPLE_FACTORS           	10833	1083308249	Gestational Age At Sampling:24 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083308249; RAW_FILE_NAME=nHILIC_1083308249; RAW_FILE_NAME=pRPLC_1083308249; RAW_FILE_NAME=nRPLC_1083308249
SUBJECT_SAMPLE_FACTORS           	10836	1083608109	Gestational Age At Sampling:10 | Gestational Age At Delivery:35 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083608109; RAW_FILE_NAME=nHILIC_1083608109; RAW_FILE_NAME=pRPLC_1083608109; RAW_FILE_NAME=nRPLC_1083608109
SUBJECT_SAMPLE_FACTORS           	10836	1083608159	Gestational Age At Sampling:15 | Gestational Age At Delivery:35 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083608159; RAW_FILE_NAME=nHILIC_1083608159; RAW_FILE_NAME=pRPLC_1083608159; RAW_FILE_NAME=nRPLC_1083608159
SUBJECT_SAMPLE_FACTORS           	10840	1084008129	Gestational Age At Sampling:12 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084008129; RAW_FILE_NAME=nHILIC_1084008129; RAW_FILE_NAME=pRPLC_1084008129; RAW_FILE_NAME=nRPLC_1084008129
SUBJECT_SAMPLE_FACTORS           	19017	1901708105	Gestational Age At Sampling:10 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901708105; RAW_FILE_NAME=nHILIC_1901708105; RAW_FILE_NAME=pRPLC_1901708105; RAW_FILE_NAME=nRPLC_1901708105
SUBJECT_SAMPLE_FACTORS           	19017	1901708165	Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901708165; RAW_FILE_NAME=nHILIC_1901708165; RAW_FILE_NAME=pRPLC_1901708165; RAW_FILE_NAME=nRPLC_1901708165
SUBJECT_SAMPLE_FACTORS           	19017	1901708255	Gestational Age At Sampling:25 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901708255; RAW_FILE_NAME=nHILIC_1901708255; RAW_FILE_NAME=pRPLC_1901708255; RAW_FILE_NAME=nRPLC_1901708255
SUBJECT_SAMPLE_FACTORS           	19017	1901708375	Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901708375; RAW_FILE_NAME=nHILIC_1901708375; RAW_FILE_NAME=pRPLC_1901708375; RAW_FILE_NAME=nRPLC_1901708375
SUBJECT_SAMPLE_FACTORS           	19024	1902408095	Gestational Age At Sampling:9 | Gestational Age At Delivery:31 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1902408095; RAW_FILE_NAME=nHILIC_1902408095; RAW_FILE_NAME=pRPLC_1902408095; RAW_FILE_NAME=nRPLC_1902408095
SUBJECT_SAMPLE_FACTORS           	19024	1902408295	Gestational Age At Sampling:29 | Gestational Age At Delivery:31 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1902408295; RAW_FILE_NAME=nHILIC_1902408295; RAW_FILE_NAME=pRPLC_1902408295; RAW_FILE_NAME=nRPLC_1902408295
SUBJECT_SAMPLE_FACTORS           	19600	1960008085	Gestational Age At Sampling:8 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1960008085; RAW_FILE_NAME=nHILIC_1960008085; RAW_FILE_NAME=pRPLC_1960008085; RAW_FILE_NAME=nRPLC_1960008085
SUBJECT_SAMPLE_FACTORS           	19600	1960008175	Gestational Age At Sampling:17 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1960008175; RAW_FILE_NAME=nHILIC_1960008175; RAW_FILE_NAME=pRPLC_1960008175; RAW_FILE_NAME=nRPLC_1960008175
SUBJECT_SAMPLE_FACTORS           	19600	1960008253	Gestational Age At Sampling:25 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1960008253; RAW_FILE_NAME=nHILIC_1960008253; RAW_FILE_NAME=pRPLC_1960008253; RAW_FILE_NAME=nRPLC_1960008253
SUBJECT_SAMPLE_FACTORS           	20070	2007008085	Gestational Age At Sampling:8 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_2007008085; RAW_FILE_NAME=nHILIC_2007008085; RAW_FILE_NAME=pRPLC_2007008085; RAW_FILE_NAME=nRPLC_2007008085
SUBJECT_SAMPLE_FACTORS           	20070	2007008335	Gestational Age At Sampling:33 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_2007008335; RAW_FILE_NAME=nHILIC_2007008335; RAW_FILE_NAME=pRPLC_2007008335; RAW_FILE_NAME=nRPLC_2007008335
SUBJECT_SAMPLE_FACTORS           	20070	2007008385	Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_2007008385; RAW_FILE_NAME=nHILIC_2007008385; RAW_FILE_NAME=pRPLC_2007008385; RAW_FILE_NAME=nRPLC_2007008385
#COLLECTION
CO:COLLECTION_SUMMARY            	Intravenous blood was collected from pregnant women
CO:SAMPLE_TYPE                   	Blood (plasma)
#TREATMENT
TR:TREATMENT_SUMMARY             	N/A
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Plasma samples were thawed on ice, prepared and analyzed randomly as previously
SP:SAMPLEPREP_SUMMARY            	described (Contrepois et al., 2015, Contrepois et al., 2018). Briefly,
SP:SAMPLEPREP_SUMMARY            	metabolites were extracted using 1:1:1 acetone:acetonitrile:methanol, evaporated
SP:SAMPLEPREP_SUMMARY            	to dryness under nitrogen and reconstituted in 1:1 methanol:water before
SP:SAMPLEPREP_SUMMARY            	analysis. Fifteen labeled metabolite internal standards (IS) were added to each
SP:SAMPLEPREP_SUMMARY            	sample to control for extraction efficiency and LC-MS performance. Complex
SP:SAMPLEPREP_SUMMARY            	lipids were prepared using a biphasic separation with cold methyl tert-butyl
SP:SAMPLEPREP_SUMMARY            	ether (MTBE), methanol and water and reconstituted in 9:1 methanol:toluene. Each
SP:SAMPLEPREP_SUMMARY            	sample was spiked-in with deuterated lipid IS (Sciex, cat#: 5040156) used for
SP:SAMPLEPREP_SUMMARY            	quantification. For quality controls, 3 reference plasma samples (40 µl plasma)
SP:SAMPLEPREP_SUMMARY            	and 1 preparation blank were processed in parallel.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	RPLC experiments were performed using a Zorbax SBaq column 2.1 x 50 mm, 1.7 μm,
CH:CHROMATOGRAPHY_SUMMARY        	100Å (Agilent Technologies, Palo Alto, CA) and mobile phase solvents consisting
CH:CHROMATOGRAPHY_SUMMARY        	of 0.06% acetic acid in water (A) and 0.06% acetic acid in methanol (B).
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Dionex Ultimate 3000 RS
CH:COLUMN_NAME                   	Agilent Zorbax SBaq (50 x 2.1 mm, 1.7 μm)
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	Data were acquired on a Thermo Q Exactive HF mass spectrometer for HILIC and a
MS:MS_COMMENTS                   	Thermo Q Exactive mass spectrometer for RPLC operated in full MS scan mode.
MS:MS_COMMENTS                   	MS/MS data were acquired on quality control samples (QC) consisting of an
MS:MS_COMMENTS                   	equimolar mixture of all samples in the study. Data from each mode were
MS:MS_COMMENTS                   	independently processed using Progenesis QI software (v2.3) (Nonlinear Dynamics,
MS:MS_COMMENTS                   	Durham, NC). Metabolic features from blanks and those that didn’t show
MS:MS_COMMENTS                   	sufficient linearity upon dilution in QC samples (r<0.6) were discarded. Only
MS:MS_COMMENTS                   	metabolic features present in >2/3 of the samples were kept for further
MS:MS_COMMENTS                   	analysis. Inter- and intra-batch variations was were corrected using the LOESS
MS:MS_COMMENTS                   	(locally estimated scatterplot smoothing Local Regression) normalization method
MS:MS_COMMENTS                   	on QC injected repetitively along the batches (span = 0.75). Missing values were
MS:MS_COMMENTS                   	imputed by drawing from a random distribution of low values in the corresponding
MS:MS_COMMENTS                   	sample.
MS:MS_RESULTS_FILE               	ST001889_AN003064_Results.txt	UNITS:MS count	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END