#METABOLOMICS WORKBENCH kcontrep_20210726_225618 DATATRACK_ID:2772 STUDY_ID:ST001890 ANALYSIS_ID:AN003066
VERSION                          	1
CREATED_ON                       	12-15-2022
#PROJECT
PR:PROJECT_TITLE                 	Preeclampsia and plasma metabolomics
PR:PROJECT_SUMMARY               	Longitudinal untargeted plasma metabolomics of pregnant women with preeclampsia
PR:INSTITUTE                     	Stanford University
PR:LAST_NAME                     	Contrepois
PR:FIRST_NAME                    	Kevin
PR:ADDRESS                       	300 Pasteur Dr
PR:EMAIL                         	kcontrep@stanford.edu
PR:PHONE                         	6506664538
PR:DOI                           	http://dx.doi.org/10.21228/M8WD84
#STUDY
ST:STUDY_TITLE                   	Multiomics Longitudinal Modeling of Preeclamptic Pregnancies (part II)
ST:STUDY_SUMMARY                 	Preeclampsia is a complex disease of pregnancy whose physiopathology remains
ST:STUDY_SUMMARY                 	unclear and that poses a threat to both mothers and infants. Specific complex
ST:STUDY_SUMMARY                 	changes in women's physiology precede a diagnosis of preeclampsia. Understanding
ST:STUDY_SUMMARY                 	multiple aspects of such a complex changes at different levels of biology can be
ST:STUDY_SUMMARY                 	enabled by simultaneous application of multiple assays. We developed prediction
ST:STUDY_SUMMARY                 	models for preeclampsia risk by analyzing six omics datasets from a longitudinal
ST:STUDY_SUMMARY                 	cohort of pregnant women. A machine learning-based multiomics model had high
ST:STUDY_SUMMARY                 	accuracy (area under the receiver operating characteristics curve (AUC) of 0.94,
ST:STUDY_SUMMARY                 	95% confidence intervals (CI): [0.90, 0.99]). A prediction model using only ten
ST:STUDY_SUMMARY                 	urine metabolites provided an accuracy of the whole metabolomic dataset and was
ST:STUDY_SUMMARY                 	validated using an independent cohort of 16 women (AUC=0.87, 95% CI: [0.76,
ST:STUDY_SUMMARY                 	0.99]). Integration with clinical variables further improved prediction accuracy
ST:STUDY_SUMMARY                 	of the urine metabolome model (AUC=0.90, 95% CI: [0.80, 0.99], urine metabolome,
ST:STUDY_SUMMARY                 	validated). We identified several biological pathways to be associated with
ST:STUDY_SUMMARY                 	preeclampsia. The findings derived from models were integrated with immune
ST:STUDY_SUMMARY                 	system cytometry data, confirming known physiological alterations associated
ST:STUDY_SUMMARY                 	with preeclampsia and suggesting novel associations between the immune and
ST:STUDY_SUMMARY                 	proteomic dynamics. While further validation in larger populations is necessary,
ST:STUDY_SUMMARY                 	these encouraging results will serve as a basis for a simple, early diagnostic
ST:STUDY_SUMMARY                 	test for preeclampsia.
ST:INSTITUTE                     	Stanford University
ST:LAST_NAME                     	Contrepois
ST:FIRST_NAME                    	Kevin
ST:ADDRESS                       	300 Pasteur Dr
ST:EMAIL                         	kcontrep@stanford.edu
ST:PHONE                         	6506664538
ST:SUBMIT_DATE                   	2021-07-26
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data
SUBJECT_SAMPLE_FACTORS           	19024	1902405109	Gestational Age At Sampling:10 | Gestational Age At Delivery:31 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1902405109; RAW_FILE_NAME=nHILIC_1902405109; RAW_FILE_NAME=pRPLC_1902405109; RAW_FILE_NAME=nRPLC_1902405109
SUBJECT_SAMPLE_FACTORS           	19017	1901705108	Gestational Age At Sampling:10 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901705108; RAW_FILE_NAME=nHILIC_1901705108; RAW_FILE_NAME=pRPLC_1901705108; RAW_FILE_NAME=nRPLC_1901705108
SUBJECT_SAMPLE_FACTORS           	10558	1055805108	Gestational Age At Sampling:10 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055805108; RAW_FILE_NAME=nHILIC_1055805108; RAW_FILE_NAME=pRPLC_1055805108; RAW_FILE_NAME=nRPLC_1055805108
SUBJECT_SAMPLE_FACTORS           	10634	1063405107	Gestational Age At Sampling:10 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063405107; RAW_FILE_NAME=nHILIC_1063405107; RAW_FILE_NAME=pRPLC_1063405107; RAW_FILE_NAME=nRPLC_1063405107
SUBJECT_SAMPLE_FACTORS           	10541	1054105108	Gestational Age At Sampling:10 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054105108; RAW_FILE_NAME=nHILIC_1054105108; RAW_FILE_NAME=pRPLC_1054105108; RAW_FILE_NAME=nRPLC_1054105108
SUBJECT_SAMPLE_FACTORS           	19600	1960005108	Gestational Age At Sampling:10 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1960005108; RAW_FILE_NAME=nHILIC_1960005108; RAW_FILE_NAME=pRPLC_1960005108; RAW_FILE_NAME=nRPLC_1960005108
SUBJECT_SAMPLE_FACTORS           	10502	1050205108	Gestational Age At Sampling:10 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050205108; RAW_FILE_NAME=nHILIC_1050205108; RAW_FILE_NAME=pRPLC_1050205108; RAW_FILE_NAME=nRPLC_1050205108
SUBJECT_SAMPLE_FACTORS           	10639	1063905109	Gestational Age At Sampling:10 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063905109; RAW_FILE_NAME=nHILIC_1063905109; RAW_FILE_NAME=pRPLC_1063905109; RAW_FILE_NAME=nRPLC_1063905109
SUBJECT_SAMPLE_FACTORS           	10816	1081605118	Gestational Age At Sampling:11 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081605118; RAW_FILE_NAME=nHILIC_1081605118; RAW_FILE_NAME=pRPLC_1081605118; RAW_FILE_NAME=nRPLC_1081605118
SUBJECT_SAMPLE_FACTORS           	10836	1083605118	Gestational Age At Sampling:11 | Gestational Age At Delivery:35 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083605118; RAW_FILE_NAME=nHILIC_1083605118; RAW_FILE_NAME=pRPLC_1083605118; RAW_FILE_NAME=nRPLC_1083605118
SUBJECT_SAMPLE_FACTORS           	10851	1085105118	Gestational Age At Sampling:11 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1085105118; RAW_FILE_NAME=nHILIC_1085105118; RAW_FILE_NAME=pRPLC_1085105118; RAW_FILE_NAME=nRPLC_1085105118
SUBJECT_SAMPLE_FACTORS           	10561	1056105118	Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1056105118; RAW_FILE_NAME=nHILIC_1056105118; RAW_FILE_NAME=pRPLC_1056105118; RAW_FILE_NAME=nRPLC_1056105118
SUBJECT_SAMPLE_FACTORS           	10809	1080905118	Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080905118; RAW_FILE_NAME=nHILIC_1080905118; RAW_FILE_NAME=pRPLC_1080905118; RAW_FILE_NAME=nRPLC_1080905118
SUBJECT_SAMPLE_FACTORS           	10849	1084905118	Gestational Age At Sampling:11 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084905118; RAW_FILE_NAME=nHILIC_1084905118; RAW_FILE_NAME=pRPLC_1084905118; RAW_FILE_NAME=nRPLC_1084905118
SUBJECT_SAMPLE_FACTORS           	10528	1052805118	Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052805118; RAW_FILE_NAME=nHILIC_1052805118; RAW_FILE_NAME=pRPLC_1052805118; RAW_FILE_NAME=nRPLC_1052805118
SUBJECT_SAMPLE_FACTORS           	10535	1053505118	Gestational Age At Sampling:11 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053505118; RAW_FILE_NAME=nHILIC_1053505118; RAW_FILE_NAME=pRPLC_1053505118; RAW_FILE_NAME=nRPLC_1053505118
SUBJECT_SAMPLE_FACTORS           	10551	1055105118	Gestational Age At Sampling:11 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1055105118; RAW_FILE_NAME=nHILIC_1055105118; RAW_FILE_NAME=pRPLC_1055105118; RAW_FILE_NAME=nRPLC_1055105118
SUBJECT_SAMPLE_FACTORS           	10833	1083305118	Gestational Age At Sampling:11 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083305118; RAW_FILE_NAME=nHILIC_1083305118; RAW_FILE_NAME=pRPLC_1083305118; RAW_FILE_NAME=nRPLC_1083305118
SUBJECT_SAMPLE_FACTORS           	10515	1051505118	Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051505118; RAW_FILE_NAME=nHILIC_1051505118; RAW_FILE_NAME=pRPLC_1051505118; RAW_FILE_NAME=nRPLC_1051505118
SUBJECT_SAMPLE_FACTORS           	10732	1073205118	Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073205118; RAW_FILE_NAME=nHILIC_1073205118; RAW_FILE_NAME=pRPLC_1073205118; RAW_FILE_NAME=nRPLC_1073205118
SUBJECT_SAMPLE_FACTORS           	10601	1060105118	Gestational Age At Sampling:11 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060105118; RAW_FILE_NAME=nHILIC_1060105118; RAW_FILE_NAME=pRPLC_1060105118; RAW_FILE_NAME=nRPLC_1060105118
SUBJECT_SAMPLE_FACTORS           	10722	1072205128	Gestational Age At Sampling:12 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072205128; RAW_FILE_NAME=nHILIC_1072205128; RAW_FILE_NAME=pRPLC_1072205128; RAW_FILE_NAME=nRPLC_1072205128
SUBJECT_SAMPLE_FACTORS           	10727	1072705128	Gestational Age At Sampling:12 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072705128; RAW_FILE_NAME=nHILIC_1072705128; RAW_FILE_NAME=pRPLC_1072705128; RAW_FILE_NAME=nRPLC_1072705128
SUBJECT_SAMPLE_FACTORS           	10547	1054705128	Gestational Age At Sampling:12 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054705128; RAW_FILE_NAME=nHILIC_1054705128; RAW_FILE_NAME=pRPLC_1054705128; RAW_FILE_NAME=nRPLC_1054705128
SUBJECT_SAMPLE_FACTORS           	10721	1072105128	Gestational Age At Sampling:12 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072105128; RAW_FILE_NAME=nHILIC_1072105128; RAW_FILE_NAME=pRPLC_1072105128; RAW_FILE_NAME=nRPLC_1072105128
SUBJECT_SAMPLE_FACTORS           	10733	1073305128	Gestational Age At Sampling:12 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073305128; RAW_FILE_NAME=nHILIC_1073305128; RAW_FILE_NAME=pRPLC_1073305128; RAW_FILE_NAME=nRPLC_1073305128
SUBJECT_SAMPLE_FACTORS           	10822	1082205138	Gestational Age At Sampling:13 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082205138; RAW_FILE_NAME=nHILIC_1082205138; RAW_FILE_NAME=pRPLC_1082205138; RAW_FILE_NAME=nRPLC_1082205138
SUBJECT_SAMPLE_FACTORS           	10803	1080305138	Gestational Age At Sampling:13 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080305138; RAW_FILE_NAME=nHILIC_1080305138; RAW_FILE_NAME=pRPLC_1080305138; RAW_FILE_NAME=nRPLC_1080305138
SUBJECT_SAMPLE_FACTORS           	10824	1082405138	Gestational Age At Sampling:13 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082405138; RAW_FILE_NAME=nHILIC_1082405138; RAW_FILE_NAME=pRPLC_1082405138; RAW_FILE_NAME=nRPLC_1082405138
SUBJECT_SAMPLE_FACTORS           	10840	1084005138	Gestational Age At Sampling:13 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084005138; RAW_FILE_NAME=nHILIC_1084005138; RAW_FILE_NAME=pRPLC_1084005138; RAW_FILE_NAME=nRPLC_1084005138
SUBJECT_SAMPLE_FACTORS           	10736	1073605138	Gestational Age At Sampling:13 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073605138; RAW_FILE_NAME=nHILIC_1073605138; RAW_FILE_NAME=pRPLC_1073605138; RAW_FILE_NAME=nRPLC_1073605138
SUBJECT_SAMPLE_FACTORS           	10712	1071205138	Gestational Age At Sampling:13 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071205138; RAW_FILE_NAME=nHILIC_1071205138; RAW_FILE_NAME=pRPLC_1071205138; RAW_FILE_NAME=nRPLC_1071205138
SUBJECT_SAMPLE_FACTORS           	10723	1072305138	Gestational Age At Sampling:13 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072305138; RAW_FILE_NAME=nHILIC_1072305138; RAW_FILE_NAME=pRPLC_1072305138; RAW_FILE_NAME=nRPLC_1072305138
SUBJECT_SAMPLE_FACTORS           	10713	1071305138	Gestational Age At Sampling:13 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071305138; RAW_FILE_NAME=nHILIC_1071305138; RAW_FILE_NAME=pRPLC_1071305138; RAW_FILE_NAME=nRPLC_1071305138
SUBJECT_SAMPLE_FACTORS           	10849	1084905148	Gestational Age At Sampling:14 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084905148; RAW_FILE_NAME=nHILIC_1084905148; RAW_FILE_NAME=pRPLC_1084905148; RAW_FILE_NAME=nRPLC_1084905148
SUBJECT_SAMPLE_FACTORS           	10524	1052405148	Gestational Age At Sampling:14 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052405148; RAW_FILE_NAME=nHILIC_1052405148; RAW_FILE_NAME=pRPLC_1052405148; RAW_FILE_NAME=nRPLC_1052405148
SUBJECT_SAMPLE_FACTORS           	10833	1083305148	Gestational Age At Sampling:14 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083305148; RAW_FILE_NAME=nHILIC_1083305148; RAW_FILE_NAME=pRPLC_1083305148; RAW_FILE_NAME=nRPLC_1083305148
SUBJECT_SAMPLE_FACTORS           	10816	1081605158	Gestational Age At Sampling:15 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081605158; RAW_FILE_NAME=nHILIC_1081605158; RAW_FILE_NAME=pRPLC_1081605158; RAW_FILE_NAME=nRPLC_1081605158
SUBJECT_SAMPLE_FACTORS           	10836	1083605158	Gestational Age At Sampling:15 | Gestational Age At Delivery:35 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083605158; RAW_FILE_NAME=nHILIC_1083605158; RAW_FILE_NAME=pRPLC_1083605158; RAW_FILE_NAME=nRPLC_1083605158
SUBJECT_SAMPLE_FACTORS           	10530	1053005158	Gestational Age At Sampling:15 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053005158; RAW_FILE_NAME=nHILIC_1053005158; RAW_FILE_NAME=pRPLC_1053005158; RAW_FILE_NAME=nRPLC_1053005158
SUBJECT_SAMPLE_FACTORS           	10851	1085105158	Gestational Age At Sampling:15 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1085105158; RAW_FILE_NAME=nHILIC_1085105158; RAW_FILE_NAME=pRPLC_1085105158; RAW_FILE_NAME=nRPLC_1085105158
SUBJECT_SAMPLE_FACTORS           	10727	1072705158	Gestational Age At Sampling:15 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072705158; RAW_FILE_NAME=nHILIC_1072705158; RAW_FILE_NAME=pRPLC_1072705158; RAW_FILE_NAME=nRPLC_1072705158
SUBJECT_SAMPLE_FACTORS           	10558	1055805158	Gestational Age At Sampling:15 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055805158; RAW_FILE_NAME=nHILIC_1055805158; RAW_FILE_NAME=pRPLC_1055805158; RAW_FILE_NAME=nRPLC_1055805158
SUBJECT_SAMPLE_FACTORS           	10541	1054105158	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054105158; RAW_FILE_NAME=nHILIC_1054105158; RAW_FILE_NAME=pRPLC_1054105158; RAW_FILE_NAME=nRPLC_1054105158
SUBJECT_SAMPLE_FACTORS           	10551	1055105158	Gestational Age At Sampling:15 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1055105158; RAW_FILE_NAME=nHILIC_1055105158; RAW_FILE_NAME=pRPLC_1055105158; RAW_FILE_NAME=nRPLC_1055105158
SUBJECT_SAMPLE_FACTORS           	10515	1051505158	Gestational Age At Sampling:15 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051505158; RAW_FILE_NAME=nHILIC_1051505158; RAW_FILE_NAME=pRPLC_1051505158; RAW_FILE_NAME=nRPLC_1051505158
SUBJECT_SAMPLE_FACTORS           	10523	1052305158	Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052305158; RAW_FILE_NAME=nHILIC_1052305158; RAW_FILE_NAME=pRPLC_1052305158; RAW_FILE_NAME=nRPLC_1052305158
SUBJECT_SAMPLE_FACTORS           	10546	1054605158	Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054605158; RAW_FILE_NAME=nHILIC_1054605158; RAW_FILE_NAME=pRPLC_1054605158; RAW_FILE_NAME=nRPLC_1054605158
SUBJECT_SAMPLE_FACTORS           	10733	1073305158	Gestational Age At Sampling:15 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073305158; RAW_FILE_NAME=nHILIC_1073305158; RAW_FILE_NAME=pRPLC_1073305158; RAW_FILE_NAME=nRPLC_1073305158
SUBJECT_SAMPLE_FACTORS           	10104	1010405168	Gestational Age At Sampling:16 | Gestational Age At Delivery:32 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1010405168; RAW_FILE_NAME=nHILIC_1010405168; RAW_FILE_NAME=pRPLC_1010405168; RAW_FILE_NAME=nRPLC_1010405168
SUBJECT_SAMPLE_FACTORS           	10822	1082205168	Gestational Age At Sampling:16 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082205168; RAW_FILE_NAME=nHILIC_1082205168; RAW_FILE_NAME=pRPLC_1082205168; RAW_FILE_NAME=nRPLC_1082205168
SUBJECT_SAMPLE_FACTORS           	10056	1005605168	Gestational Age At Sampling:16 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005605168; RAW_FILE_NAME=nHILIC_1005605168; RAW_FILE_NAME=pRPLC_1005605168; RAW_FILE_NAME=nRPLC_1005605168
SUBJECT_SAMPLE_FACTORS           	10809	1080905168	Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080905168; RAW_FILE_NAME=nHILIC_1080905168; RAW_FILE_NAME=pRPLC_1080905168; RAW_FILE_NAME=nRPLC_1080905168
SUBJECT_SAMPLE_FACTORS           	10824	1082405168	Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082405168; RAW_FILE_NAME=nHILIC_1082405168; RAW_FILE_NAME=pRPLC_1082405168; RAW_FILE_NAME=nRPLC_1082405168
SUBJECT_SAMPLE_FACTORS           	10840	1084005168	Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084005168; RAW_FILE_NAME=nHILIC_1084005168; RAW_FILE_NAME=pRPLC_1084005168; RAW_FILE_NAME=nRPLC_1084005168
SUBJECT_SAMPLE_FACTORS           	19017	1901705168	Gestational Age At Sampling:16 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901705168; RAW_FILE_NAME=nHILIC_1901705168; RAW_FILE_NAME=pRPLC_1901705168; RAW_FILE_NAME=nRPLC_1901705168
SUBJECT_SAMPLE_FACTORS           	10535	1053505168	Gestational Age At Sampling:16 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053505168; RAW_FILE_NAME=nHILIC_1053505168; RAW_FILE_NAME=pRPLC_1053505168; RAW_FILE_NAME=nRPLC_1053505168
SUBJECT_SAMPLE_FACTORS           	10634	1063405169	Gestational Age At Sampling:16 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063405169; RAW_FILE_NAME=nHILIC_1063405169; RAW_FILE_NAME=pRPLC_1063405169; RAW_FILE_NAME=nRPLC_1063405169
SUBJECT_SAMPLE_FACTORS           	10538	1053805168	Gestational Age At Sampling:16 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053805168; RAW_FILE_NAME=nHILIC_1053805168; RAW_FILE_NAME=pRPLC_1053805168; RAW_FILE_NAME=nRPLC_1053805168
SUBJECT_SAMPLE_FACTORS           	10547	1054705168	Gestational Age At Sampling:16 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054705168; RAW_FILE_NAME=nHILIC_1054705168; RAW_FILE_NAME=pRPLC_1054705168; RAW_FILE_NAME=nRPLC_1054705168
SUBJECT_SAMPLE_FACTORS           	10804	1080405168	Gestational Age At Sampling:16 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1080405168; RAW_FILE_NAME=nHILIC_1080405168; RAW_FILE_NAME=pRPLC_1080405168; RAW_FILE_NAME=nRPLC_1080405168
SUBJECT_SAMPLE_FACTORS           	10112	1011205168	Gestational Age At Sampling:16 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1011205168; RAW_FILE_NAME=nHILIC_1011205168; RAW_FILE_NAME=pRPLC_1011205168; RAW_FILE_NAME=nRPLC_1011205168
SUBJECT_SAMPLE_FACTORS           	10712	1071205168	Gestational Age At Sampling:16 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071205168; RAW_FILE_NAME=nHILIC_1071205168; RAW_FILE_NAME=pRPLC_1071205168; RAW_FILE_NAME=nRPLC_1071205168
SUBJECT_SAMPLE_FACTORS           	10601	1060105168	Gestational Age At Sampling:16 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060105168; RAW_FILE_NAME=nHILIC_1060105168; RAW_FILE_NAME=pRPLC_1060105168; RAW_FILE_NAME=nRPLC_1060105168
SUBJECT_SAMPLE_FACTORS           	10639	1063905169	Gestational Age At Sampling:16 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063905169; RAW_FILE_NAME=nHILIC_1063905169; RAW_FILE_NAME=pRPLC_1063905169; RAW_FILE_NAME=nRPLC_1063905169
SUBJECT_SAMPLE_FACTORS           	10722	1072205178	Gestational Age At Sampling:17 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072205178; RAW_FILE_NAME=nHILIC_1072205178; RAW_FILE_NAME=pRPLC_1072205178; RAW_FILE_NAME=nRPLC_1072205178
SUBJECT_SAMPLE_FACTORS           	10505	1050505178	Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050505178; RAW_FILE_NAME=nHILIC_1050505178; RAW_FILE_NAME=pRPLC_1050505178; RAW_FILE_NAME=nRPLC_1050505178
SUBJECT_SAMPLE_FACTORS           	10533	1053305178	Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053305178; RAW_FILE_NAME=nHILIC_1053305178; RAW_FILE_NAME=pRPLC_1053305178; RAW_FILE_NAME=nRPLC_1053305178
SUBJECT_SAMPLE_FACTORS           	10553	1055305178	Gestational Age At Sampling:17 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055305178; RAW_FILE_NAME=nHILIC_1055305178; RAW_FILE_NAME=pRPLC_1055305178; RAW_FILE_NAME=nRPLC_1055305178
SUBJECT_SAMPLE_FACTORS           	10736	1073605178	Gestational Age At Sampling:17 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073605178; RAW_FILE_NAME=nHILIC_1073605178; RAW_FILE_NAME=pRPLC_1073605178; RAW_FILE_NAME=nRPLC_1073605178
SUBJECT_SAMPLE_FACTORS           	19600	1960005179	Gestational Age At Sampling:17 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1960005179; RAW_FILE_NAME=nHILIC_1960005179; RAW_FILE_NAME=pRPLC_1960005179; RAW_FILE_NAME=nRPLC_1960005179
SUBJECT_SAMPLE_FACTORS           	10723	1072305178	Gestational Age At Sampling:17 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072305178; RAW_FILE_NAME=nHILIC_1072305178; RAW_FILE_NAME=pRPLC_1072305178; RAW_FILE_NAME=nRPLC_1072305178
SUBJECT_SAMPLE_FACTORS           	10713	1071305178	Gestational Age At Sampling:17 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071305178; RAW_FILE_NAME=nHILIC_1071305178; RAW_FILE_NAME=pRPLC_1071305178; RAW_FILE_NAME=nRPLC_1071305178
SUBJECT_SAMPLE_FACTORS           	10803	1080305188	Gestational Age At Sampling:18 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080305188; RAW_FILE_NAME=nHILIC_1080305188; RAW_FILE_NAME=pRPLC_1080305188; RAW_FILE_NAME=nRPLC_1080305188
SUBJECT_SAMPLE_FACTORS           	10524	1052405188	Gestational Age At Sampling:18 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052405188; RAW_FILE_NAME=nHILIC_1052405188; RAW_FILE_NAME=pRPLC_1052405188; RAW_FILE_NAME=nRPLC_1052405188
SUBJECT_SAMPLE_FACTORS           	10721	1072105188	Gestational Age At Sampling:18 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072105188; RAW_FILE_NAME=nHILIC_1072105188; RAW_FILE_NAME=pRPLC_1072105188; RAW_FILE_NAME=nRPLC_1072105188
SUBJECT_SAMPLE_FACTORS           	10548	1054805188	Gestational Age At Sampling:18 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054805188; RAW_FILE_NAME=nHILIC_1054805188; RAW_FILE_NAME=pRPLC_1054805188; RAW_FILE_NAME=nRPLC_1054805188
SUBJECT_SAMPLE_FACTORS           	10732	1073205188	Gestational Age At Sampling:18 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073205188; RAW_FILE_NAME=nHILIC_1073205188; RAW_FILE_NAME=pRPLC_1073205188; RAW_FILE_NAME=nRPLC_1073205188
SUBJECT_SAMPLE_FACTORS           	10503	1050305188	Gestational Age At Sampling:18 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050305188; RAW_FILE_NAME=nHILIC_1050305188; RAW_FILE_NAME=pRPLC_1050305188; RAW_FILE_NAME=nRPLC_1050305188
SUBJECT_SAMPLE_FACTORS           	10849	1084905228	Gestational Age At Sampling:22 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084905228; RAW_FILE_NAME=nHILIC_1084905228; RAW_FILE_NAME=pRPLC_1084905228; RAW_FILE_NAME=nRPLC_1084905228
SUBJECT_SAMPLE_FACTORS           	10833	1083305228	Gestational Age At Sampling:22 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083305228; RAW_FILE_NAME=nHILIC_1083305228; RAW_FILE_NAME=pRPLC_1083305228; RAW_FILE_NAME=nRPLC_1083305228
SUBJECT_SAMPLE_FACTORS           	10816	1081605238	Gestational Age At Sampling:23 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081605238; RAW_FILE_NAME=nHILIC_1081605238; RAW_FILE_NAME=pRPLC_1081605238; RAW_FILE_NAME=nRPLC_1081605238
SUBJECT_SAMPLE_FACTORS           	10104	1010405238	Gestational Age At Sampling:23 | Gestational Age At Delivery:32 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1010405238; RAW_FILE_NAME=nHILIC_1010405238; RAW_FILE_NAME=pRPLC_1010405238; RAW_FILE_NAME=nRPLC_1010405238
SUBJECT_SAMPLE_FACTORS           	10824	1082405238	Gestational Age At Sampling:23 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082405238; RAW_FILE_NAME=nHILIC_1082405238; RAW_FILE_NAME=pRPLC_1082405238; RAW_FILE_NAME=nRPLC_1082405238
SUBJECT_SAMPLE_FACTORS           	10836	1083605248	Gestational Age At Sampling:24 | Gestational Age At Delivery:35 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083605248; RAW_FILE_NAME=nHILIC_1083605248; RAW_FILE_NAME=pRPLC_1083605248; RAW_FILE_NAME=nRPLC_1083605248
SUBJECT_SAMPLE_FACTORS           	10056	1005605248	Gestational Age At Sampling:24 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005605248; RAW_FILE_NAME=nHILIC_1005605248; RAW_FILE_NAME=pRPLC_1005605248; RAW_FILE_NAME=nRPLC_1005605248
SUBJECT_SAMPLE_FACTORS           	10851	1085105248	Gestational Age At Sampling:24 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1085105248; RAW_FILE_NAME=nHILIC_1085105248; RAW_FILE_NAME=pRPLC_1085105248; RAW_FILE_NAME=nRPLC_1085105248
SUBJECT_SAMPLE_FACTORS           	10553	1055305248	Gestational Age At Sampling:24 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055305248; RAW_FILE_NAME=nHILIC_1055305248; RAW_FILE_NAME=pRPLC_1055305248; RAW_FILE_NAME=nRPLC_1055305248
SUBJECT_SAMPLE_FACTORS           	10840	1084005248	Gestational Age At Sampling:24 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084005248; RAW_FILE_NAME=nHILIC_1084005248; RAW_FILE_NAME=pRPLC_1084005248; RAW_FILE_NAME=nRPLC_1084005248
SUBJECT_SAMPLE_FACTORS           	10634	1063405249	Gestational Age At Sampling:24 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063405249; RAW_FILE_NAME=nHILIC_1063405249; RAW_FILE_NAME=pRPLC_1063405249; RAW_FILE_NAME=nRPLC_1063405249
SUBJECT_SAMPLE_FACTORS           	10547	1054705248	Gestational Age At Sampling:24 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054705248; RAW_FILE_NAME=nHILIC_1054705248; RAW_FILE_NAME=pRPLC_1054705248; RAW_FILE_NAME=nRPLC_1054705248
SUBJECT_SAMPLE_FACTORS           	10732	1073205248	Gestational Age At Sampling:24 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073205248; RAW_FILE_NAME=nHILIC_1073205248; RAW_FILE_NAME=pRPLC_1073205248; RAW_FILE_NAME=nRPLC_1073205248
SUBJECT_SAMPLE_FACTORS           	10722	1072205258	Gestational Age At Sampling:25 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072205258; RAW_FILE_NAME=nHILIC_1072205258; RAW_FILE_NAME=pRPLC_1072205258; RAW_FILE_NAME=nRPLC_1072205258
SUBJECT_SAMPLE_FACTORS           	10561	1056105258	Gestational Age At Sampling:25 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1056105258; RAW_FILE_NAME=nHILIC_1056105258; RAW_FILE_NAME=pRPLC_1056105258; RAW_FILE_NAME=nRPLC_1056105258
SUBJECT_SAMPLE_FACTORS           	19017	1901705258	Gestational Age At Sampling:25 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901705258; RAW_FILE_NAME=nHILIC_1901705258; RAW_FILE_NAME=pRPLC_1901705258; RAW_FILE_NAME=nRPLC_1901705258
SUBJECT_SAMPLE_FACTORS           	10558	1055805258	Gestational Age At Sampling:25 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055805258; RAW_FILE_NAME=nHILIC_1055805258; RAW_FILE_NAME=pRPLC_1055805258; RAW_FILE_NAME=nRPLC_1055805258
SUBJECT_SAMPLE_FACTORS           	10736	1073605258	Gestational Age At Sampling:25 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073605258; RAW_FILE_NAME=nHILIC_1073605258; RAW_FILE_NAME=pRPLC_1073605258; RAW_FILE_NAME=nRPLC_1073605258
SUBJECT_SAMPLE_FACTORS           	19600	1960005259	Gestational Age At Sampling:25 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1960005259; RAW_FILE_NAME=nHILIC_1960005259; RAW_FILE_NAME=pRPLC_1960005259; RAW_FILE_NAME=nRPLC_1960005259
SUBJECT_SAMPLE_FACTORS           	10515	1051505258	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051505258; RAW_FILE_NAME=nHILIC_1051505258; RAW_FILE_NAME=pRPLC_1051505258; RAW_FILE_NAME=nRPLC_1051505258
SUBJECT_SAMPLE_FACTORS           	10548	1054805258	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054805258; RAW_FILE_NAME=nHILIC_1054805258; RAW_FILE_NAME=pRPLC_1054805258; RAW_FILE_NAME=nRPLC_1054805258
SUBJECT_SAMPLE_FACTORS           	10712	1071205258	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071205258; RAW_FILE_NAME=nHILIC_1071205258; RAW_FILE_NAME=pRPLC_1071205258; RAW_FILE_NAME=nRPLC_1071205258
SUBJECT_SAMPLE_FACTORS           	10723	1072305258	Gestational Age At Sampling:25 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072305258; RAW_FILE_NAME=nHILIC_1072305258; RAW_FILE_NAME=pRPLC_1072305258; RAW_FILE_NAME=nRPLC_1072305258
SUBJECT_SAMPLE_FACTORS           	10502	1050205258	Gestational Age At Sampling:25 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050205258; RAW_FILE_NAME=nHILIC_1050205258; RAW_FILE_NAME=pRPLC_1050205258; RAW_FILE_NAME=nRPLC_1050205258
SUBJECT_SAMPLE_FACTORS           	10822	1082205268	Gestational Age At Sampling:26 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082205268; RAW_FILE_NAME=nHILIC_1082205268; RAW_FILE_NAME=pRPLC_1082205268; RAW_FILE_NAME=nRPLC_1082205268
SUBJECT_SAMPLE_FACTORS           	10505	1050505268	Gestational Age At Sampling:26 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050505268; RAW_FILE_NAME=nHILIC_1050505268; RAW_FILE_NAME=pRPLC_1050505268; RAW_FILE_NAME=nRPLC_1050505268
SUBJECT_SAMPLE_FACTORS           	10533	1053305268	Gestational Age At Sampling:26 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053305268; RAW_FILE_NAME=nHILIC_1053305268; RAW_FILE_NAME=pRPLC_1053305268; RAW_FILE_NAME=nRPLC_1053305268
SUBJECT_SAMPLE_FACTORS           	10809	1080905268	Gestational Age At Sampling:26 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080905268; RAW_FILE_NAME=nHILIC_1080905268; RAW_FILE_NAME=pRPLC_1080905268; RAW_FILE_NAME=nRPLC_1080905268
SUBJECT_SAMPLE_FACTORS           	10524	1052405268	Gestational Age At Sampling:26 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052405268; RAW_FILE_NAME=nHILIC_1052405268; RAW_FILE_NAME=pRPLC_1052405268; RAW_FILE_NAME=nRPLC_1052405268
SUBJECT_SAMPLE_FACTORS           	10551	1055105268	Gestational Age At Sampling:26 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1055105268; RAW_FILE_NAME=nHILIC_1055105268; RAW_FILE_NAME=pRPLC_1055105268; RAW_FILE_NAME=nRPLC_1055105268
SUBJECT_SAMPLE_FACTORS           	10112	1011205268	Gestational Age At Sampling:26 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1011205268; RAW_FILE_NAME=nHILIC_1011205268; RAW_FILE_NAME=pRPLC_1011205268; RAW_FILE_NAME=nRPLC_1011205268
SUBJECT_SAMPLE_FACTORS           	10601	1060105269	Gestational Age At Sampling:26 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060105269; RAW_FILE_NAME=nHILIC_1060105269; RAW_FILE_NAME=pRPLC_1060105269; RAW_FILE_NAME=nRPLC_1060105269
SUBJECT_SAMPLE_FACTORS           	10733	1073305268	Gestational Age At Sampling:26 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073305268; RAW_FILE_NAME=nHILIC_1073305268; RAW_FILE_NAME=pRPLC_1073305268; RAW_FILE_NAME=nRPLC_1073305268
SUBJECT_SAMPLE_FACTORS           	10803	1080305278	Gestational Age At Sampling:27 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080305278; RAW_FILE_NAME=nHILIC_1080305278; RAW_FILE_NAME=pRPLC_1080305278; RAW_FILE_NAME=nRPLC_1080305278
SUBJECT_SAMPLE_FACTORS           	10535	1053505278	Gestational Age At Sampling:27 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053505278; RAW_FILE_NAME=nHILIC_1053505278; RAW_FILE_NAME=pRPLC_1053505278; RAW_FILE_NAME=nRPLC_1053505278
SUBJECT_SAMPLE_FACTORS           	10541	1054105278	Gestational Age At Sampling:27 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054105278; RAW_FILE_NAME=nHILIC_1054105278; RAW_FILE_NAME=pRPLC_1054105278; RAW_FILE_NAME=nRPLC_1054105278
SUBJECT_SAMPLE_FACTORS           	10721	1072105278	Gestational Age At Sampling:27 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072105278; RAW_FILE_NAME=nHILIC_1072105278; RAW_FILE_NAME=pRPLC_1072105278; RAW_FILE_NAME=nRPLC_1072105278
SUBJECT_SAMPLE_FACTORS           	10503	1050305278	Gestational Age At Sampling:27 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050305278; RAW_FILE_NAME=nHILIC_1050305278; RAW_FILE_NAME=pRPLC_1050305278; RAW_FILE_NAME=nRPLC_1050305278
SUBJECT_SAMPLE_FACTORS           	10713	1071305278	Gestational Age At Sampling:27 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071305278; RAW_FILE_NAME=nHILIC_1071305278; RAW_FILE_NAME=pRPLC_1071305278; RAW_FILE_NAME=nRPLC_1071305278
SUBJECT_SAMPLE_FACTORS           	10639	1063905278	Gestational Age At Sampling:27 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063905278; RAW_FILE_NAME=nHILIC_1063905278; RAW_FILE_NAME=pRPLC_1063905278; RAW_FILE_NAME=nRPLC_1063905278
SUBJECT_SAMPLE_FACTORS           	10727	1072705288	Gestational Age At Sampling:28 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072705288; RAW_FILE_NAME=nHILIC_1072705288; RAW_FILE_NAME=pRPLC_1072705288; RAW_FILE_NAME=nRPLC_1072705288
SUBJECT_SAMPLE_FACTORS           	10528	1052805288	Gestational Age At Sampling:28 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052805288; RAW_FILE_NAME=nHILIC_1052805288; RAW_FILE_NAME=pRPLC_1052805288; RAW_FILE_NAME=nRPLC_1052805288
SUBJECT_SAMPLE_FACTORS           	10538	1053805288	Gestational Age At Sampling:28 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053805288; RAW_FILE_NAME=nHILIC_1053805288; RAW_FILE_NAME=pRPLC_1053805288; RAW_FILE_NAME=nRPLC_1053805288
SUBJECT_SAMPLE_FACTORS           	10804	1080405288	Gestational Age At Sampling:28 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1080405288; RAW_FILE_NAME=nHILIC_1080405288; RAW_FILE_NAME=pRPLC_1080405288; RAW_FILE_NAME=nRPLC_1080405288
SUBJECT_SAMPLE_FACTORS           	10523	1052305288	Gestational Age At Sampling:28 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052305288; RAW_FILE_NAME=nHILIC_1052305288; RAW_FILE_NAME=pRPLC_1052305288; RAW_FILE_NAME=nRPLC_1052305288
SUBJECT_SAMPLE_FACTORS           	10546	1054605298	Gestational Age At Sampling:29 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054605298; RAW_FILE_NAME=nHILIC_1054605298; RAW_FILE_NAME=pRPLC_1054605298; RAW_FILE_NAME=nRPLC_1054605298
SUBJECT_SAMPLE_FACTORS           	19024	1902405308	Gestational Age At Sampling:30 | Gestational Age At Delivery:31 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1902405308; RAW_FILE_NAME=nHILIC_1902405308; RAW_FILE_NAME=pRPLC_1902405308; RAW_FILE_NAME=nRPLC_1902405308
SUBJECT_SAMPLE_FACTORS           	10104	1010405318	Gestational Age At Sampling:31 | Gestational Age At Delivery:32 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1010405318; RAW_FILE_NAME=nHILIC_1010405318; RAW_FILE_NAME=pRPLC_1010405318; RAW_FILE_NAME=nRPLC_1010405318
SUBJECT_SAMPLE_FACTORS           	10530	1053005338	Gestational Age At Sampling:33 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053005338; RAW_FILE_NAME=nHILIC_1053005338; RAW_FILE_NAME=pRPLC_1053005338; RAW_FILE_NAME=nRPLC_1053005338
SUBJECT_SAMPLE_FACTORS           	20070	2007005338	Gestational Age At Sampling:33 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_2007005338; RAW_FILE_NAME=nHILIC_2007005338; RAW_FILE_NAME=pRPLC_2007005338; RAW_FILE_NAME=nRPLC_2007005338
SUBJECT_SAMPLE_FACTORS           	10056	1005605348	Gestational Age At Sampling:34 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005605348; RAW_FILE_NAME=nHILIC_1005605348; RAW_FILE_NAME=pRPLC_1005605348; RAW_FILE_NAME=nRPLC_1005605348
SUBJECT_SAMPLE_FACTORS           	10530	1053005358	Gestational Age At Sampling:35 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053005358; RAW_FILE_NAME=nHILIC_1053005358; RAW_FILE_NAME=pRPLC_1053005358; RAW_FILE_NAME=nRPLC_1053005358
SUBJECT_SAMPLE_FACTORS           	10722	1072205368	Gestational Age At Sampling:36 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072205368; RAW_FILE_NAME=nHILIC_1072205368; RAW_FILE_NAME=pRPLC_1072205368; RAW_FILE_NAME=nRPLC_1072205368
SUBJECT_SAMPLE_FACTORS           	10553	1055305369	Gestational Age At Sampling:36 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055305369; RAW_FILE_NAME=nHILIC_1055305369; RAW_FILE_NAME=pRPLC_1055305369; RAW_FILE_NAME=nRPLC_1055305369
SUBJECT_SAMPLE_FACTORS           	10505	1050505378	Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050505378; RAW_FILE_NAME=nHILIC_1050505378; RAW_FILE_NAME=pRPLC_1050505378; RAW_FILE_NAME=nRPLC_1050505378
SUBJECT_SAMPLE_FACTORS           	10533	1053305378	Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1053305378; RAW_FILE_NAME=nHILIC_1053305378; RAW_FILE_NAME=pRPLC_1053305378; RAW_FILE_NAME=nRPLC_1053305378
SUBJECT_SAMPLE_FACTORS           	19017	1901705378	Gestational Age At Sampling:37 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1901705378; RAW_FILE_NAME=nHILIC_1901705378; RAW_FILE_NAME=pRPLC_1901705378; RAW_FILE_NAME=nRPLC_1901705378
SUBJECT_SAMPLE_FACTORS           	10524	1052405378	Gestational Age At Sampling:37 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052405378; RAW_FILE_NAME=nHILIC_1052405378; RAW_FILE_NAME=pRPLC_1052405378; RAW_FILE_NAME=nRPLC_1052405378
SUBJECT_SAMPLE_FACTORS           	10558	1055805379	Gestational Age At Sampling:37 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1055805379; RAW_FILE_NAME=nHILIC_1055805379; RAW_FILE_NAME=pRPLC_1055805379; RAW_FILE_NAME=nRPLC_1055805379
SUBJECT_SAMPLE_FACTORS           	10528	1052805388	Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052805388; RAW_FILE_NAME=nHILIC_1052805388; RAW_FILE_NAME=pRPLC_1052805388; RAW_FILE_NAME=nRPLC_1052805388
SUBJECT_SAMPLE_FACTORS           	20070	2007005388	Gestational Age At Sampling:38 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_2007005388; RAW_FILE_NAME=nHILIC_2007005388; RAW_FILE_NAME=pRPLC_2007005388; RAW_FILE_NAME=nRPLC_2007005388
SUBJECT_SAMPLE_FACTORS           	10541	1054105388	Gestational Age At Sampling:38 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054105388; RAW_FILE_NAME=nHILIC_1054105388; RAW_FILE_NAME=pRPLC_1054105388; RAW_FILE_NAME=nRPLC_1054105388
SUBJECT_SAMPLE_FACTORS           	10547	1054705388	Gestational Age At Sampling:38 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054705388; RAW_FILE_NAME=nHILIC_1054705388; RAW_FILE_NAME=pRPLC_1054705388; RAW_FILE_NAME=nRPLC_1054705388
SUBJECT_SAMPLE_FACTORS           	10538	1053805398	Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053805398; RAW_FILE_NAME=nHILIC_1053805398; RAW_FILE_NAME=pRPLC_1053805398; RAW_FILE_NAME=nRPLC_1053805398
SUBJECT_SAMPLE_FACTORS           	10112	1011205398	Gestational Age At Sampling:39 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1011205398; RAW_FILE_NAME=nHILIC_1011205398; RAW_FILE_NAME=pRPLC_1011205398; RAW_FILE_NAME=nRPLC_1011205398
SUBJECT_SAMPLE_FACTORS           	10515	1051505398	Gestational Age At Sampling:39 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1051505398; RAW_FILE_NAME=nHILIC_1051505398; RAW_FILE_NAME=pRPLC_1051505398; RAW_FILE_NAME=nRPLC_1051505398
SUBJECT_SAMPLE_FACTORS           	10503	1050305408	Gestational Age At Sampling:40 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050305408; RAW_FILE_NAME=nHILIC_1050305408; RAW_FILE_NAME=pRPLC_1050305408; RAW_FILE_NAME=nRPLC_1050305408
SUBJECT_SAMPLE_FACTORS           	10546	1054605409	Gestational Age At Sampling:40 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054605409; RAW_FILE_NAME=nHILIC_1054605409; RAW_FILE_NAME=pRPLC_1054605409; RAW_FILE_NAME=nRPLC_1054605409
SUBJECT_SAMPLE_FACTORS           	10502	1050205418	Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050205418; RAW_FILE_NAME=nHILIC_1050205418; RAW_FILE_NAME=pRPLC_1050205418; RAW_FILE_NAME=nRPLC_1050205418
SUBJECT_SAMPLE_FACTORS           	10523	1052305418	Gestational Age At Sampling:41 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052305418; RAW_FILE_NAME=nHILIC_1052305418; RAW_FILE_NAME=pRPLC_1052305418; RAW_FILE_NAME=nRPLC_1052305418
SUBJECT_SAMPLE_FACTORS           	10822	1082205458	Gestational Age At Sampling:45 | Gestational Age At Delivery:33 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1082205458; RAW_FILE_NAME=nHILIC_1082205458; RAW_FILE_NAME=pRPLC_1082205458; RAW_FILE_NAME=nRPLC_1082205458
SUBJECT_SAMPLE_FACTORS           	10721	1072105458	Gestational Age At Sampling:45 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1072105458; RAW_FILE_NAME=nHILIC_1072105458; RAW_FILE_NAME=pRPLC_1072105458; RAW_FILE_NAME=nRPLC_1072105458
SUBJECT_SAMPLE_FACTORS           	10723	1072305458	Gestational Age At Sampling:45 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1072305458; RAW_FILE_NAME=nHILIC_1072305458; RAW_FILE_NAME=pRPLC_1072305458; RAW_FILE_NAME=nRPLC_1072305458
SUBJECT_SAMPLE_FACTORS           	10851	1085105468	Gestational Age At Sampling:46 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1085105468; RAW_FILE_NAME=nHILIC_1085105468; RAW_FILE_NAME=pRPLC_1085105468; RAW_FILE_NAME=nRPLC_1085105468
SUBJECT_SAMPLE_FACTORS           	10849	1084905468	Gestational Age At Sampling:46 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084905468; RAW_FILE_NAME=nHILIC_1084905468; RAW_FILE_NAME=pRPLC_1084905468; RAW_FILE_NAME=nRPLC_1084905468
SUBJECT_SAMPLE_FACTORS           	10634	1063405467	Gestational Age At Sampling:46 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063405467; RAW_FILE_NAME=nHILIC_1063405467; RAW_FILE_NAME=pRPLC_1063405467; RAW_FILE_NAME=nRPLC_1063405467
SUBJECT_SAMPLE_FACTORS           	10804	1080405468	Gestational Age At Sampling:46 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1080405468; RAW_FILE_NAME=nHILIC_1080405468; RAW_FILE_NAME=pRPLC_1080405468; RAW_FILE_NAME=nRPLC_1080405468
SUBJECT_SAMPLE_FACTORS           	10736	1073605468	Gestational Age At Sampling:46 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1073605468; RAW_FILE_NAME=nHILIC_1073605468; RAW_FILE_NAME=pRPLC_1073605468; RAW_FILE_NAME=nRPLC_1073605468
SUBJECT_SAMPLE_FACTORS           	10833	1083305468	Gestational Age At Sampling:46 | Gestational Age At Delivery:39 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1083305468; RAW_FILE_NAME=nHILIC_1083305468; RAW_FILE_NAME=pRPLC_1083305468; RAW_FILE_NAME=nRPLC_1083305468
SUBJECT_SAMPLE_FACTORS           	10639	1063905468	Gestational Age At Sampling:46 | Gestational Age At Delivery:41 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1063905468; RAW_FILE_NAME=nHILIC_1063905468; RAW_FILE_NAME=pRPLC_1063905468; RAW_FILE_NAME=nRPLC_1063905468
SUBJECT_SAMPLE_FACTORS           	10840	1084005478	Gestational Age At Sampling:47 | Gestational Age At Delivery:37 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1084005478; RAW_FILE_NAME=nHILIC_1084005478; RAW_FILE_NAME=pRPLC_1084005478; RAW_FILE_NAME=nRPLC_1084005478
SUBJECT_SAMPLE_FACTORS           	10732	1073205478	Gestational Age At Sampling:47 | Gestational Age At Delivery:40 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073205478; RAW_FILE_NAME=nHILIC_1073205478; RAW_FILE_NAME=pRPLC_1073205478; RAW_FILE_NAME=nRPLC_1073205478
SUBJECT_SAMPLE_FACTORS           	10733	1073305478	Gestational Age At Sampling:47 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1073305478; RAW_FILE_NAME=nHILIC_1073305478; RAW_FILE_NAME=pRPLC_1073305478; RAW_FILE_NAME=nRPLC_1073305478
SUBJECT_SAMPLE_FACTORS           	10816	1081605488	Gestational Age At Sampling:48 | Gestational Age At Delivery:30 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1081605488; RAW_FILE_NAME=nHILIC_1081605488; RAW_FILE_NAME=pRPLC_1081605488; RAW_FILE_NAME=nRPLC_1081605488
SUBJECT_SAMPLE_FACTORS           	10601	1060105489	Gestational Age At Sampling:48 | Gestational Age At Delivery:40 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1060105489; RAW_FILE_NAME=nHILIC_1060105489; RAW_FILE_NAME=pRPLC_1060105489; RAW_FILE_NAME=nRPLC_1060105489
SUBJECT_SAMPLE_FACTORS           	10713	1071305488	Gestational Age At Sampling:48 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1071305488; RAW_FILE_NAME=nHILIC_1071305488; RAW_FILE_NAME=pRPLC_1071305488; RAW_FILE_NAME=nRPLC_1071305488
SUBJECT_SAMPLE_FACTORS           	10803	1080305528	Gestational Age At Sampling:52 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1080305528; RAW_FILE_NAME=nHILIC_1080305528; RAW_FILE_NAME=pRPLC_1080305528; RAW_FILE_NAME=nRPLC_1080305528
SUBJECT_SAMPLE_FACTORS           	10056	1005605068	Gestational Age At Sampling:6 | Gestational Age At Delivery:36 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_1005605068; RAW_FILE_NAME=nHILIC_1005605068; RAW_FILE_NAME=pRPLC_1005605068; RAW_FILE_NAME=nRPLC_1005605068
SUBJECT_SAMPLE_FACTORS           	20070	2007005088	Gestational Age At Sampling:8 | Gestational Age At Delivery:38 | Preeclampsia:1	RAW_FILE_NAME=pHILIC_2007005088; RAW_FILE_NAME=nHILIC_2007005088; RAW_FILE_NAME=pRPLC_2007005088; RAW_FILE_NAME=nRPLC_2007005088
SUBJECT_SAMPLE_FACTORS           	10505	1050505098	Gestational Age At Sampling:9 | Gestational Age At Delivery:37 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1050505098; RAW_FILE_NAME=nHILIC_1050505098; RAW_FILE_NAME=pRPLC_1050505098; RAW_FILE_NAME=nRPLC_1050505098
SUBJECT_SAMPLE_FACTORS           	10538	1053805098	Gestational Age At Sampling:9 | Gestational Age At Delivery:39 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1053805098; RAW_FILE_NAME=nHILIC_1053805098; RAW_FILE_NAME=pRPLC_1053805098; RAW_FILE_NAME=nRPLC_1053805098
SUBJECT_SAMPLE_FACTORS           	10523	1052305098	Gestational Age At Sampling:9 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1052305098; RAW_FILE_NAME=nHILIC_1052305098; RAW_FILE_NAME=pRPLC_1052305098; RAW_FILE_NAME=nRPLC_1052305098
SUBJECT_SAMPLE_FACTORS           	10546	1054605098	Gestational Age At Sampling:9 | Gestational Age At Delivery:41 | Preeclampsia:-	RAW_FILE_NAME=pHILIC_1054605098; RAW_FILE_NAME=nHILIC_1054605098; RAW_FILE_NAME=pRPLC_1054605098; RAW_FILE_NAME=nRPLC_1054605098
#COLLECTION
CO:COLLECTION_SUMMARY            	Urine was collected from pregnant women
CO:SAMPLE_TYPE                   	Urine
#TREATMENT
TR:TREATMENT_SUMMARY             	N/A
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Urine samples were thawed on ice, prepared and analyzed randomly as previously
SP:SAMPLEPREP_SUMMARY            	described (Contrepois et al., 2015). Briefly, urine samples were diluted 1:4
SP:SAMPLEPREP_SUMMARY            	with 75% acetonitrile and 100% water for HILIC- and RPLC-MS experiments,
SP:SAMPLEPREP_SUMMARY            	respectively. Each sample was spiked-in with 15 analytical-grade IS.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	HILIC experiments were performed using a ZIC-HILIC column 2.1 x 100 mm, 3.5 μm,
CH:CHROMATOGRAPHY_SUMMARY        	200Å (Merck Millipore, Darmstadt, Germany) and mobile phase solvents consisting
CH:CHROMATOGRAPHY_SUMMARY        	of 10 mM ammonium acetate in 50/50 acetonitrile/water (A) and 10 mM ammonium
CH:CHROMATOGRAPHY_SUMMARY        	acetate in 95/5 acetonitrile/water (B).
CH:INSTRUMENT_NAME               	Thermo Dionex Ultimate 3000 RS
CH:COLUMN_NAME                   	EMD Millipore ZIC-HILIC (100 x 2.1mm,3.5um)
CH:SOLVENT_A                     	50% acetonitrile/50% water; 10mM ammonium acetate
CH:SOLVENT_B                     	95% acetonitrile/5% water; 10mM ammonium acetate
CH:CHROMATOGRAPHY_TYPE           	HILIC
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive HF hybrid Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:MS_COMMENTS                   	Data were acquired on a Thermo Q Exactive HF mass spectrometer for HILIC and a
MS:MS_COMMENTS                   	Thermo Q Exactive mass spectrometer for RPLC operated in full MS scan mode.
MS:MS_COMMENTS                   	MS/MS data were acquired on quality control samples (QC) consisting of an
MS:MS_COMMENTS                   	equimolar mixture of all samples in the study. Data from each mode were
MS:MS_COMMENTS                   	independently processed using Progenesis QI software (v2.3) (Nonlinear Dynamics,
MS:MS_COMMENTS                   	Durham, NC). Metabolic features from blanks and those that didn’t show
MS:MS_COMMENTS                   	sufficient linearity upon dilution in QC samples (r<0.6) were discarded. Only
MS:MS_COMMENTS                   	metabolic features present in >2/3 of the samples were kept for further
MS:MS_COMMENTS                   	analysis. Inter- and intra-batch variations was were corrected using the LOESS
MS:MS_COMMENTS                   	(locally estimated scatterplot smoothing Local Regression) normalization method
MS:MS_COMMENTS                   	on QC injected repetitively along the batches (span = 0.75). Missing values were
MS:MS_COMMENTS                   	imputed by drawing from a random distribution of low values in the corresponding
MS:MS_COMMENTS                   	sample.
MS:ION_MODE                      	POSITIVE
MS:MS_RESULTS_FILE               	ST001890_AN003066_Results.txt	UNITS:MS count	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END