#METABOLOMICS WORKBENCH alhughes3_20210722_081823 DATATRACK_ID:2764 STUDY_ID:ST001901 ANALYSIS_ID:AN003091 VERSION 1 CREATED_ON 02-08-2024 #PROJECT PR:PROJECT_TITLE Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid PR:PROJECT_TITLE Stress PR:PROJECT_SUMMARY Amino acids are essential building blocks of life. However, increasing evidence PR:PROJECT_SUMMARY suggests that elevated amino acids cause cellular toxicity associated with PR:PROJECT_SUMMARY numerous metabolic disorders. How cells cope with elevated amino acids remains PR:PROJECT_SUMMARY poorly understood. Here, we show that a previously identified cellular PR:PROJECT_SUMMARY structure, the mitochondrial-derived compartment (MDC), functions to protect PR:PROJECT_SUMMARY cells from amino acid stress. In response to amino acid elevation, MDCs are PR:PROJECT_SUMMARY generated from mitochondria, where they selectively sequester and deplete SLC25A PR:PROJECT_SUMMARY nutrient carriers and their associated import receptor Tom70 from the organelle. PR:PROJECT_SUMMARY Generation of MDCs promotes amino acid catabolism, and their formation occurs PR:PROJECT_SUMMARY simultaneously with transporter removal at the plasma membrane via the PR:PROJECT_SUMMARY multi-vesicular body (MVB) pathway. Combined loss of vacuolar amino acid PR:PROJECT_SUMMARY storage, MVBs and MDCs renders cells sensitive to high amino acid stress. Thus, PR:PROJECT_SUMMARY we propose that MDCs operate as part of a coordinated cell network that PR:PROJECT_SUMMARY facilitates amino acid homoeostasis through post-translational nutrient PR:PROJECT_SUMMARY transporter remodeling. PR:INSTITUTE University of Utah School of Medicine PR:DEPARTMENT Biochemistry PR:LABORATORY Hughes Lab PR:LAST_NAME Hughes PR:FIRST_NAME Adam PR:ADDRESS 15 N Medical Drive East, RM 4100, Salt Lake City, UT, 84112, USA PR:EMAIL hughes@biochem.utah.edu PR:PHONE 8015812481 PR:DOI http://dx.doi.org/10.21228/M83X4N #STUDY ST:STUDY_TITLE Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid ST:STUDY_TITLE Stress ST:STUDY_SUMMARY Amino acids are essential building blocks of life. However, increasing evidence ST:STUDY_SUMMARY suggests that elevated amino acids cause cellular toxicity associated with ST:STUDY_SUMMARY numerous metabolic disorders. How cells cope with elevated amino acids remains ST:STUDY_SUMMARY poorly understood. Here, we show that a previously identified cellular ST:STUDY_SUMMARY structure, the mitochondrial-derived compartment (MDC), functions to protect ST:STUDY_SUMMARY cells from amino acid stress. In response to amino acid elevation, MDCs are ST:STUDY_SUMMARY generated from mitochondria, where they selectively sequester and deplete SLC25A ST:STUDY_SUMMARY nutrient carriers and their associated import receptor Tom70 from the organelle. ST:STUDY_SUMMARY Generation of MDCs promotes amino acid catabolism, and their formation occurs ST:STUDY_SUMMARY simultaneously with transporter removal at the plasma membrane via the ST:STUDY_SUMMARY multi-vesicular body (MVB) pathway. Combined loss of vacuolar amino acid ST:STUDY_SUMMARY storage, MVBs and MDCs renders cells sensitive to high amino acid stress. Thus, ST:STUDY_SUMMARY we propose that MDCs operate as part of a coordinated cell network that ST:STUDY_SUMMARY facilitates amino acid homoeostasis through post-translational nutrient ST:STUDY_SUMMARY transporter remodeling. ST:INSTITUTE University of Utah School of Medicine ST:DEPARTMENT Biochemistry ST:LABORATORY Hughes Lab ST:LAST_NAME Hughes ST:FIRST_NAME Adam ST:ADDRESS 15 N Medical Drive East, RM 4100, Salt Lake City, UT, 84112, USA ST:EMAIL hughes@biochem.utah.edu ST:PHONE 8015812481 ST:SUBMIT_DATE 2021-07-22 #SUBJECT SU:SUBJECT_TYPE Yeast SU:SUBJECT_SPECIES Saccharomyces cerevisiae SU:TAXONOMY_ID 4932 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_6A Genotype:gem1 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_6A.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_6B Genotype:gem1 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_6B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_6C Genotype:gem1 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_6C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_6D Genotype:gem1 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_6D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_2A Genotype:gem1 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_2A.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_2B Genotype:gem1 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_2B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_2C Genotype:gem1 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_2C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_2D Genotype:gem1 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_2D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_11 Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_11.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_17 Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_17.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_23 Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_23.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_5a Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_5a.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_11 Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_11.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_17 Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_17.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_23 Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_23.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_5 Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_5.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_10 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_10.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_16 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_16.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_22 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_22.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_4 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_4.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_10 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_10.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_16 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_16.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_22 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_22.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_4 Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_4.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_12 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_12.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_18 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_18.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_24 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_24.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_5 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_5.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_12 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_12.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_18 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_18.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_24 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_24.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_6 Genotype:gem1 knockout | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_6.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_4D Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_4D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_8A Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_8A.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_8B Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_8B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_8C Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_8C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_8D Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_8D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_4A Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_4A.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_4B Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_4B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_4C Genotype:gem1 vps27 double knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_4C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_QC5 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_QC5.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_QC6 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_QC6.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_QC7 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_QC7.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_QC8 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_QC8.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC1 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC1.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC2 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC2.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC3 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC3.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC4 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_QC4.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_QC1 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_QC1.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_QC2 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_QC2.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_QC3 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_QC3.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_QC4 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_QC4.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_QC1 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_QC1.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_QC2 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_QC2.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_QC3 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_QC3.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_QC4 Genotype:Pooled QC sample | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_QC4.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_PB4 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_PB4.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_PB5 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_PB5.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_PB6 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_PB6.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB1 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB1.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB2 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB2.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB3 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB3.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB4 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_PB4.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_PB1 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_PB1.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_PB2 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_PB2.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_PB3 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_PB3.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_PB4 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_PB4.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_PB1 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_PB1.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_PB2 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_PB2.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_PB3 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_PB3.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_PB4 Genotype:Process blank | Media:N/A | Treatment:N/A RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_PB4.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_7A Genotype:vps27 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_7A.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_7B Genotype:vps27 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_7B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_7C Genotype:vps27 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_7C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_7D Genotype:vps27 knockout | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_7D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_3A Genotype:vps27 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_3A.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_3B Genotype:vps27 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_3B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_3C Genotype:vps27 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_3C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_3D Genotype:vps27 knockout | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_3D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_34 Genotype:wild-type | Media:MinD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_34.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_43 Genotype:wild-type | Media:MinD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_43.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_52 Genotype:wild-type | Media:MinD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_52.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_5A Genotype:wild-type | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_5A.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_5B Genotype:wild-type | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_5B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_5C Genotype:wild-type | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_5C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_5D Genotype:wild-type | Media:SD+Leucine | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_5D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_1A Genotype:wild-type | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_1A.D; Experiment identifier=MDCY-205; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_1B Genotype:wild-type | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_1B.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_1C Genotype:wild-type | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_1C.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200818_7200_20to1_Yeast_1D Genotype:wild-type | Media:SD+Leucine | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200818_7200_20to1_Yeast_1D.D; Experiment identifier=MDCY-205; Submission date=08.18.20; Analysis=Whole cell mtabolites; Figures=S7G SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_31 Genotype:wild-type | Media:SD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_31.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_40 Genotype:wild-type | Media:SD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_40.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_49 Genotype:wild-type | Media:SD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_49.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_14 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_14.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_2 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_2.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_20 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_20.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_8 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_8.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_14 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_14.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_2 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_2.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_20 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_20.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_8 Genotype:wild-type | Media:YPAD | Treatment:ConcA RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_8.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_28 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_28.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_37 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_37.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20190522_5977b_10to1_Yeast_46 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20190522_5977b_10to1_Yeast_46.cdf; Experiment identifier=MDCY-80; Submission date=05.17.19; Analysis=Whole cell mtabolites; Figures=S3 SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_1 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_1.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_13 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_13.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_19 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_19.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_7 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_7.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_1 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_1.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_13 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_13.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_19 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_19.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_7 Genotype:wild-type | Media:YPAD | Treatment:DMSO RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_7.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_15 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_15.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_21 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_21.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_3 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_3.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_9 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200807_MSTFA_5977b_20to1_SC_9.cdf; Experiment identifier=MDCY-202; Submission date=7/8/20; Analysis=Whole cell mtabolites; Figures=2A, 2C, S2A, S3G, 6A, 6B, S6A SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_15 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_15.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_21 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_21.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_3 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_3.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E SUBJECT_SAMPLE_FACTORS - Hughes_Schuler_20200825_7200_20to1_MSTFA_9 Genotype:wild-type | Media:YPAD | Treatment:Rap RAW_FILE_NAME=Hughes_Schuler_20200825_7200_20to1_MSTFA_9.D; Experiment identifier=MDCY-211; Submission date=08.25.20; Analysis=13C6-Glucosetracing; Figures=2D, 2E, S2B, S2C, S2D, S3H, 6B, 6C, 6D, S6B, S6C, S6D, S6E #COLLECTION CO:COLLECTION_SUMMARY See STAR methods file CO:COLLECTION_PROTOCOL_FILENAME STAR_methods.pdf CO:SAMPLE_TYPE Yeast cells #TREATMENT TR:TREATMENT_SUMMARY See STAR Methods file TR:TREATMENT_PROTOCOL_FILENAME STAR_methods.pdf #SAMPLEPREP SP:SAMPLEPREP_SUMMARY See STAR Methods file SP:SAMPLEPREP_PROTOCOL_FILENAME STAR_methods.pdf #CHROMATOGRAPHY CH:INSTRUMENT_NAME Agilent 7200 CH:COLUMN_NAME Phenomenex Zebron ZB-WAXplus (30m x 0.25mm,0.25um) CH:CHROMATOGRAPHY_TYPE GC #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Agilent 7200 MS:INSTRUMENT_TYPE QTOF MS:MS_TYPE EI MS:MS_COMMENTS N/A MS:ION_MODE POSITIVE #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS area under the curve MS_METABOLITE_DATA_START Samples Hughes_Schuler_20200825_7200_20to1_MSTFA_11 Hughes_Schuler_20200825_7200_20to1_MSTFA_17 Hughes_Schuler_20200825_7200_20to1_MSTFA_23 Hughes_Schuler_20200825_7200_20to1_MSTFA_5 Hughes_Schuler_20200825_7200_20to1_MSTFA_10 Hughes_Schuler_20200825_7200_20to1_MSTFA_16 Hughes_Schuler_20200825_7200_20to1_MSTFA_22 Hughes_Schuler_20200825_7200_20to1_MSTFA_4 Hughes_Schuler_20200825_7200_20to1_MSTFA_12 Hughes_Schuler_20200825_7200_20to1_MSTFA_18 Hughes_Schuler_20200825_7200_20to1_MSTFA_24 Hughes_Schuler_20200825_7200_20to1_MSTFA_6 Hughes_Schuler_20200825_7200_20to1_MSTFA_QC1 Hughes_Schuler_20200825_7200_20to1_MSTFA_QC2 Hughes_Schuler_20200825_7200_20to1_MSTFA_QC3 Hughes_Schuler_20200825_7200_20to1_MSTFA_QC4 Hughes_Schuler_20200825_7200_20to1_MSTFA_PB1 Hughes_Schuler_20200825_7200_20to1_MSTFA_PB2 Hughes_Schuler_20200825_7200_20to1_MSTFA_PB3 Hughes_Schuler_20200825_7200_20to1_MSTFA_PB4 Hughes_Schuler_20200825_7200_20to1_MSTFA_14 Hughes_Schuler_20200825_7200_20to1_MSTFA_2 Hughes_Schuler_20200825_7200_20to1_MSTFA_20 Hughes_Schuler_20200825_7200_20to1_MSTFA_8 Hughes_Schuler_20200825_7200_20to1_MSTFA_1 Hughes_Schuler_20200825_7200_20to1_MSTFA_13 Hughes_Schuler_20200825_7200_20to1_MSTFA_19 Hughes_Schuler_20200825_7200_20to1_MSTFA_7 Hughes_Schuler_20200825_7200_20to1_MSTFA_15 Hughes_Schuler_20200825_7200_20to1_MSTFA_21 Hughes_Schuler_20200825_7200_20to1_MSTFA_3 Hughes_Schuler_20200825_7200_20to1_MSTFA_9 Factors Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA Genotype:gem1 knockout | Media:YPAD | Treatment:ConcA Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO Genotype:gem1 knockout | Media:YPAD | Treatment:DMSO Genotype:gem1 knockout | Media:YPAD | Treatment:Rap Genotype:gem1 knockout | Media:YPAD | Treatment:Rap Genotype:gem1 knockout | Media:YPAD | Treatment:Rap Genotype:gem1 knockout | Media:YPAD | Treatment:Rap Genotype:Pooled QC sample | Media:N/A | Treatment:N/A Genotype:Pooled QC sample | Media:N/A | Treatment:N/A Genotype:Pooled QC sample | Media:N/A | Treatment:N/A Genotype:Pooled QC sample | Media:N/A | Treatment:N/A Genotype:Process blank | Media:N/A | Treatment:N/A Genotype:Process blank | Media:N/A | Treatment:N/A Genotype:Process blank | Media:N/A | Treatment:N/A Genotype:Process blank | Media:N/A | Treatment:N/A Genotype:wild-type | Media:YPAD | Treatment:ConcA Genotype:wild-type | Media:YPAD | Treatment:ConcA Genotype:wild-type | Media:YPAD | Treatment:ConcA Genotype:wild-type | Media:YPAD | Treatment:ConcA Genotype:wild-type | Media:YPAD | Treatment:DMSO Genotype:wild-type | Media:YPAD | Treatment:DMSO Genotype:wild-type | Media:YPAD | Treatment:DMSO Genotype:wild-type | Media:YPAD | Treatment:DMSO Genotype:wild-type | Media:YPAD | Treatment:Rap Genotype:wild-type | Media:YPAD | Treatment:Rap Genotype:wild-type | Media:YPAD | Treatment:Rap Genotype:wild-type | Media:YPAD | Treatment:Rap 2-aminobutyrate m0 13210.0000 18139.0000 14519.0000 14287.0000 13270.0000 15345.0000 14070.0000 13213.0000 13695.0000 12433.0000 13546.0000 13139.0000 21707.0000 15119.0000 14224.0000 13939.0000 29585.0000 13322.0000 13573.0000 14262.0000 14814.0000 14252.0000 13127.0000 13829.0000 14652.0000 14087.0000 14224.0000 13097.0000 12596.0000 14124.0000 13943.0000 14026.0000 2-aminobutyrate m1 2130.0000 3105.0000 2724.0000 3099.0000 1791.0000 2994.0000 2439.0000 2202.0000 2125.0000 2197.0000 2062.0000 2357.0000 3980.0000 2491.0000 2499.0000 2549.0000 5895.0000 2454.0000 2830.0000 2559.0000 2507.0000 2476.0000 2224.0000 1645.0000 2696.0000 2669.0000 2418.0000 1690.0000 2537.0000 2282.0000 2171.0000 2423.0000 2-aminobutyrate m2 617.0000 1100.0000 73.0000 1013.0000 835.0000 1052.0000 923.0000 925.0000 1061.0000 963.0000 826.0000 777.0000 1042.0000 1006.0000 927.0000 905.0000 2108.0000 1058.0000 1086.0000 920.0000 1204.0000 892.0000 699.0000 955.0000 999.0000 864.0000 1031.0000 926.0000 806.0000 841.0000 1141.0000 1133.0000 2-aminobutyrate m3 2587.0000 1287.0000 2045.0000 205.0000 1830.0000 773.0000 952.0000 1748.0000 511.0000 1592.0000 1515.0000 706.0000 237.0000 846.0000 204.0000 508.0000 246.0000 980.0000 2403.0000 3021.0000 402.0000 796.0000 250.0000 1696.0000 952.0000 1283.0000 407.0000 2-aminobutyrate m4 41.0000 79.0000 477.0000 35.0000 73.0000 280.0000 276.0000 570.0000 556.0000 292.0000 343.0000 47.0000 72.0000 310.0000 31.0000 74.0000 191.0000 483.0000 239.0000 574.0000 701.0000 175.0000 112.0000 395.0000 280.0000 66.0000 386.0000 2-hydroxyglutaric acid m0 123.0000 230.0000 98.0000 110.0000 121.0000 135.0000 245.0000 227.0000 7.0000 6.0000 51.0000 72.0000 152.0000 156.0000 154.0000 102.0000 173.0000 15.0000 67.0000 32.0000 271.0000 236.0000 63.0000 225.0000 163.0000 79.0000 199.0000 23.0000 46.0000 153.0000 90.0000 93.0000 2-hydroxyglutaric acid m1 26.0000 72.0000 41.0000 11.0000 20.0000 80.0000 74.0000 41.0000 3.0000 26.0000 35.0000 16.0000 44.0000 17.0000 38.0000 24.0000 10.0000 7.0000 7.0000 6.0000 74.0000 62.0000 24.0000 58.0000 44.0000 49.0000 71.0000 51.0000 30.0000 33.0000 10.0000 21.0000 2-hydroxyglutaric acid m2 131.0000 166.0000 124.0000 168.0000 396.0000 292.0000 378.0000 241.0000 37.0000 7.0000 46.0000 62.0000 10.0000 251.0000 193.0000 48.0000 17.0000 9.0000 7.0000 297.0000 311.0000 42.0000 162.0000 491.0000 484.0000 381.0000 440.0000 130.0000 124.0000 71.0000 23.0000 2-hydroxyglutaric acid m3 33.0000 68.0000 49.0000 74.0000 158.0000 144.0000 113.0000 129.0000 14.0000 39.0000 24.0000 45.0000 19.0000 63.0000 56.0000 9.0000 6.0000 5.0000 1.0000 10.0000 117.0000 162.0000 127.0000 24.0000 231.0000 112.0000 169.0000 148.0000 24.0000 5.0000 20.0000 8.0000 2-hydroxyglutaric acid m4 17.0000 19.0000 17.0000 64.0000 165.0000 11.0000 208.0000 190.0000 12.0000 48.0000 9.0000 40.0000 187.0000 141.0000 83.0000 60.0000 7.0000 14.0000 5.0000 328.0000 195.0000 223.0000 184.0000 215.0000 285.0000 277.0000 235.0000 34.0000 51.0000 10.0000 34.0000 2-hydroxyglutaric acid m5 51.0000 59.0000 22.0000 6.0000 58.0000 61.0000 45.0000 36.0000 8.0000 4.0000 6.0000 10.0000 94.0000 80.0000 21.0000 94.0000 19.0000 13.0000 17.0000 10.0000 111.0000 225.0000 151.0000 193.0000 91.0000 55.0000 26.0000 90.0000 41.0000 25.0000 38.0000 31.0000 2-ketoglutamic acid m0 35.0000 7.0000 35.0000 9.0000 8.0000 34.0000 8.0000 31.0000 150.0000 55.0000 126.0000 155.0000 49.0000 31.0000 88.0000 17.0000 7.0000 11.0000 21.0000 14.0000 10.0000 8.0000 27.0000 9.0000 2.0000 19.0000 9.0000 75.0000 81.0000 136.0000 62.0000 2-ketoglutamic acid m1 33.0000 15.0000 14.0000 17.0000 7.0000 16.0000 20.0000 18.0000 24.0000 19.0000 97.0000 11.0000 7.0000 5.0000 9.0000 13.0000 24.0000 6.0000 9.0000 5.0000 11.0000 33.0000 19.0000 8.0000 14.0000 8.0000 18.0000 18.0000 13.0000 13.0000 2-ketoglutamic acid m2 44.0000 13.0000 8.0000 26.0000 1.0000 105.0000 14.0000 40.0000 48.0000 22.0000 55.0000 29.0000 31.0000 15.0000 25.0000 23.0000 67.0000 8.0000 28.0000 35.0000 20.0000 51.0000 81.0000 23.0000 20.0000 18.0000 12.0000 47.0000 2-ketoglutamic acid m3 5.0000 7.0000 41.0000 22.0000 24.0000 80.0000 33.0000 7.0000 12.0000 9.0000 60.0000 36.0000 21.0000 28.0000 50.0000 7.0000 6.0000 16.0000 27.0000 21.0000 5.0000 14.0000 23.0000 52.0000 109.0000 40.0000 12.0000 46.0000 41.0000 2-ketoglutamic acid m4 6.0000 15.0000 12.0000 10.0000 35.0000 6.0000 23.0000 6.0000 16.0000 15.0000 13.0000 17.0000 18.0000 19.0000 26.0000 19.0000 4.0000 2.0000 19.0000 13.0000 3.0000 10.0000 30.0000 32.0000 20.0000 70.0000 28.0000 27.0000 12.0000 2-ketoglutamic acid m5 13.0000 6.0000 5.0000 13.0000 28.0000 10.0000 8.0000 18.0000 59.0000 41.0000 17.0000 22.0000 15.0000 18.0000 17.0000 21.0000 6.0000 6.0000 2.0000 15.0000 14.0000 49.0000 29.0000 20.0000 12.0000 21.0000 45.0000 34.0000 25.0000 3-hydroxybutyrate m0 1307.0000 1451.0000 1321.0000 1151.0000 1543.0000 1480.0000 1336.0000 986.0000 1171.0000 964.0000 1374.0000 1043.0000 1702.0000 1123.0000 986.0000 2432.0000 1963.0000 749.0000 843.0000 747.0000 896.0000 997.0000 1243.0000 1048.0000 861.0000 1182.0000 1203.0000 1257.0000 983.0000 1451.0000 843.0000 722.0000 3-hydroxybutyrate m1 1524.0000 242.0000 1515.0000 1508.0000 1485.0000 194.0000 1291.0000 1217.0000 170.0000 70.0000 1313.0000 1373.0000 2437.0000 1390.0000 1380.0000 430.0000 3853.0000 1532.0000 1469.0000 1483.0000 166.0000 1578.0000 176.0000 1242.0000 1259.0000 1471.0000 1396.0000 1427.0000 1594.0000 1599.0000 1430.0000 1338.0000 3-hydroxybutyrate m2 322.0000 506.0000 156.0000 152.0000 84.0000 483.0000 211.0000 352.0000 224.0000 97.0000 187.0000 405.0000 127.0000 342.0000 240.0000 200.0000 889.0000 39.0000 341.0000 61.0000 425.0000 76.0000 214.0000 344.0000 308.0000 59.0000 308.0000 107.0000 289.0000 191.0000 472.0000 355.0000 3-hydroxybutyrate m3 13.0000 117.0000 27.0000 29.0000 94.0000 119.0000 123.0000 147.0000 137.0000 6.0000 99.0000 88.0000 214.0000 161.0000 81.0000 124.0000 16.0000 12.0000 137.0000 121.0000 44.0000 65.0000 55.0000 45.0000 99.0000 96.0000 122.0000 37.0000 29.0000 120.0000 12.0000 3-hydroxybutyrate m4 10.0000 70.0000 20.0000 68.0000 43.0000 49.0000 47.0000 32.0000 19.0000 4.0000 21.0000 24.0000 15.0000 35.0000 4.0000 77.0000 7.0000 23.0000 12.0000 133.0000 101.0000 91.0000 60.0000 57.0000 68.0000 28.0000 39.0000 38.0000 35.0000 11.0000 alanine m0 28413.0000 34675.0000 28715.0000 27374.0000 30762.0000 36389.0000 27171.0000 32113.0000 107590.0000 118843.0000 132112.0000 123879.0000 46144.0000 41132.0000 37771.0000 38941.0000 15593.0000 5893.0000 6370.0000 4982.0000 8771.0000 10129.0000 9519.0000 7123.0000 19735.0000 20091.0000 16694.0000 18292.0000 77097.0000 71232.0000 66609.0000 62489.0000 alanine m1 6685.0000 8440.0000 7043.0000 6101.0000 7096.0000 7973.0000 5544.0000 6853.0000 26001.0000 28937.0000 30426.0000 29713.0000 11119.0000 9982.0000 9069.0000 9563.0000 3879.0000 1346.0000 1578.0000 1273.0000 2430.0000 2383.0000 2752.0000 2034.0000 5019.0000 4532.0000 3831.0000 4192.0000 19621.0000 17238.0000 17016.0000 15549.0000 alanine m2 7844.0000 9216.0000 7641.0000 6850.0000 5561.0000 6575.0000 5335.0000 5653.0000 32632.0000 34964.0000 38178.0000 36073.0000 13469.0000 11673.0000 10770.0000 11253.0000 1570.0000 462.0000 817.0000 443.0000 2661.0000 2573.0000 2588.0000 2372.0000 3699.0000 3367.0000 3219.0000 3148.0000 31145.0000 26759.0000 26772.0000 24182.0000 alanine m3 18061.0000 22516.0000 18809.0000 16345.0000 11316.0000 12703.0000 10524.0000 11923.0000 76392.0000 89218.0000 98376.0000 88528.0000 33122.0000 30758.0000 29317.0000 29444.0000 427.0000 222.0000 131.0000 316.0000 6914.0000 5619.0000 6018.0000 5621.0000 6750.0000 6338.0000 5506.0000 5763.0000 85061.0000 73933.0000 74968.0000 62065.0000 asparagine m0 780.0000 1336.0000 929.0000 972.0000 1584.0000 1619.0000 1176.0000 1335.0000 1370.0000 1721.0000 1951.0000 2092.0000 1317.0000 1245.0000 849.0000 935.0000 278.0000 27.0000 122.0000 144.0000 423.0000 486.0000 415.0000 360.0000 1407.0000 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1583.0000 1448.0000 1439.0000 1304.0000 366.0000 273.0000 476.0000 5043.0000 4929.0000 4793.0000 4347.0000 2858.0000 2460.0000 2364.0000 2411.0000 576.0000 826.0000 840.0000 606.0000 succinate m3 785.0000 811.0000 26.0000 533.0000 904.0000 982.0000 1055.0000 1092.0000 484.0000 377.0000 472.0000 187.0000 838.0000 708.0000 1163.0000 1095.0000 892.0000 403.0000 94.0000 225.0000 3074.0000 2510.0000 2840.0000 2723.0000 2704.0000 2722.0000 3138.0000 2705.0000 464.0000 538.0000 89.0000 23.0000 succinate m4 11286.0000 2841.0000 2852.0000 1874.0000 3937.0000 4072.0000 4563.0000 4377.0000 9367.0000 8462.0000 10662.0000 1056.0000 6347.0000 5241.0000 4727.0000 5031.0000 19853.0000 9480.0000 9893.0000 8899.0000 14971.0000 15592.0000 19383.0000 16447.0000 10758.0000 17400.0000 17475.0000 14224.0000 1612.0000 1516.0000 8390.0000 7032.0000 threonine m0 230945.0000 270902.0000 231595.0000 198708.0000 157880.0000 165840.0000 146199.0000 166228.0000 91324.0000 105858.0000 118226.0000 113331.0000 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24464.0000 29119.0000 24586.0000 21690.0000 19220.0000 19756.0000 18083.0000 19871.0000 33706.0000 38877.0000 43741.0000 42246.0000 26270.0000 24161.0000 20892.0000 23109.0000 3310.0000 1055.0000 1362.0000 1107.0000 20740.0000 18287.0000 21492.0000 21201.0000 23590.0000 24572.0000 24079.0000 22795.0000 35872.0000 32900.0000 32344.0000 27318.0000 threonine m4 8571.0000 10942.0000 9179.0000 7821.0000 9149.0000 9968.0000 9364.0000 9490.0000 35270.0000 41500.0000 47230.0000 46759.0000 18418.0000 16778.0000 14638.0000 15119.0000 563.0000 89.0000 413.0000 246.0000 8066.0000 7223.0000 8140.0000 7479.0000 6926.0000 6840.0000 6503.0000 5950.0000 43269.0000 38767.0000 37515.0000 32094.0000 tyrosine m0 6643.0000 7512.0000 5717.0000 5995.0000 7462.0000 7440.0000 6418.0000 7476.0000 35331.0000 36804.0000 39821.0000 32569.0000 13805.0000 12847.0000 11870.0000 13376.0000 2884.0000 519.0000 1344.0000 620.0000 2219.0000 2083.0000 2291.0000 2312.0000 6539.0000 6131.0000 8459.0000 7043.0000 30002.0000 30525.0000 27865.0000 25643.0000 tyrosine m1 2020.0000 2060.0000 2172.0000 1955.0000 1710.0000 1789.0000 2059.0000 3399.0000 11061.0000 11044.0000 11980.0000 10974.0000 3517.0000 4723.0000 3238.0000 5369.0000 201.0000 161.0000 163.0000 620.0000 3412.0000 1083.0000 1556.0000 2311.0000 1320.0000 2761.0000 8994.0000 9126.0000 8626.0000 7383.0000 tyrosine m2 1332.0000 455.0000 698.0000 139.0000 1115.0000 352.0000 1005.0000 5384.0000 5725.0000 6276.0000 4923.0000 2732.0000 1908.0000 1436.0000 1934.0000 30.0000 164.0000 46.0000 365.0000 207.0000 873.0000 1325.0000 1867.0000 1044.0000 5099.0000 4849.0000 4141.0000 3927.0000 tyrosine m3 236.0000 374.0000 76.0000 1102.0000 1380.0000 1631.0000 853.0000 481.0000 1140.0000 163.0000 155.0000 499.0000 96.0000 109.0000 70.0000 310.0000 150.0000 880.0000 1146.0000 968.0000 837.0000 1631.0000 tyrosine m4 262.0000 403.0000 191.0000 50.0000 224.0000 194.0000 364.0000 184.0000 110.0000 66.0000 135.0000 40.0000 28.0000 75.0000 19.0000 41.0000 75.0000 65.0000 36.0000 142.0000 71.0000 35.0000 205.0000 374.0000 tyrosine m5 467.0000 201.0000 86.0000 256.0000 559.0000 114.0000 1009.0000 662.0000 331.0000 545.0000 445.0000 49.0000 161.0000 64.0000 431.0000 167.0000 137.0000 66.0000 414.0000 279.0000 71.0000 45.0000 173.0000 147.0000 256.0000 276.0000 tyrosine m6 154.0000 27.0000 27.0000 143.0000 44.0000 70.0000 67.0000 144.0000 398.0000 112.0000 151.0000 229.0000 583.0000 133.0000 94.0000 33.0000 156.0000 81.0000 56.0000 32.0000 13.0000 109.0000 38.0000 104.0000 161.0000 460.0000 182.0000 450.0000 tyrosine m7 1328.0000 1297.0000 396.0000 595.0000 457.0000 1951.0000 946.0000 1266.0000 358.0000 866.0000 1425.0000 1873.0000 959.0000 992.0000 686.0000 919.0000 1097.0000 47.0000 339.0000 132.0000 868.0000 80.0000 143.0000 137.0000 54.0000 787.0000 104.0000 1017.0000 1106.0000 1588.0000 1625.0000 1809.0000 tyrosine m8 83.0000 1073.0000 162.0000 460.0000 203.0000 395.0000 871.0000 443.0000 545.0000 587.0000 324.0000 616.0000 194.0000 173.0000 79.0000 18.0000 326.0000 40.0000 117.0000 752.0000 124.0000 86.0000 56.0000 737.0000 57.0000 912.0000 346.0000 145.0000 tyrosine m9 137.0000 146.0000 751.0000 341.0000 328.0000 491.0000 287.0000 3080.0000 3076.0000 2611.0000 3043.0000 1557.0000 1466.0000 992.0000 1289.0000 266.0000 53.0000 99.0000 65.0000 245.0000 523.0000 130.0000 74.0000 235.0000 156.0000 354.0000 3997.0000 3642.0000 3398.0000 2913.0000 valine m0 3435.0000 4593.0000 3216.0000 3293.0000 3205.0000 4826.0000 3075.0000 3714.0000 8612.0000 8562.0000 9657.0000 9248.0000 5303.0000 4721.0000 4248.0000 4279.0000 4456.0000 1519.0000 1660.0000 1401.0000 2282.0000 2882.0000 2218.0000 1668.0000 3243.0000 3728.0000 3234.0000 3361.0000 9848.0000 9436.0000 9752.0000 8506.0000 valine m1 692.0000 1040.0000 771.0000 829.0000 819.0000 1170.0000 599.0000 881.0000 2118.0000 2040.0000 2157.0000 2376.0000 1228.0000 1151.0000 966.0000 1145.0000 1125.0000 402.0000 342.0000 309.0000 552.0000 477.0000 586.0000 465.0000 873.0000 824.0000 730.0000 564.0000 1987.0000 2099.0000 2334.0000 2033.0000 valine m2 465.0000 681.0000 508.0000 475.0000 739.0000 758.0000 563.0000 675.0000 1646.0000 1470.0000 1734.0000 1583.0000 1002.0000 909.0000 892.0000 744.0000 406.0000 160.0000 223.0000 130.0000 426.0000 534.0000 407.0000 445.0000 788.0000 797.0000 503.0000 674.0000 1733.0000 1480.0000 1736.0000 1545.0000 valine m3 441.0000 641.0000 472.0000 465.0000 570.0000 818.0000 574.0000 586.0000 1012.0000 960.0000 1202.0000 1104.0000 908.0000 772.0000 627.0000 677.0000 683.0000 210.0000 236.0000 290.0000 527.0000 376.0000 293.0000 578.0000 783.0000 827.0000 791.0000 789.0000 1238.0000 1264.0000 1102.0000 836.0000 valine m4 380.0000 454.0000 314.0000 327.0000 312.0000 419.0000 359.0000 100.0000 233.0000 454.0000 517.0000 463.0000 616.0000 422.0000 421.0000 426.0000 595.0000 237.0000 220.0000 231.0000 363.0000 276.0000 272.0000 362.0000 356.0000 105.0000 326.0000 415.0000 594.0000 634.0000 586.0000 496.0000 valine m5 265.0000 358.0000 268.0000 271.0000 388.0000 372.0000 381.0000 266.0000 556.0000 532.0000 730.0000 549.0000 588.0000 537.0000 371.0000 477.0000 119.0000 56.0000 42.0000 74.0000 535.0000 382.0000 410.0000 399.0000 487.0000 500.0000 345.0000 502.0000 1119.0000 983.0000 963.0000 777.0000 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name pubchem_id inchi_key kegg_id other_id other_id_type ri ri_type moverz_quant 2-aminobutyrate m0 2-aminobutyrate m1 2-aminobutyrate m2 2-aminobutyrate m3 2-aminobutyrate m4 2-hydroxyglutaric acid m0 2-hydroxyglutaric acid m1 2-hydroxyglutaric acid m2 2-hydroxyglutaric acid m3 2-hydroxyglutaric acid m4 2-hydroxyglutaric acid m5 2-ketoglutamic acid m0 2-ketoglutamic acid m1 2-ketoglutamic acid m2 2-ketoglutamic acid m3 2-ketoglutamic acid m4 2-ketoglutamic acid m5 3-hydroxybutyrate m0 3-hydroxybutyrate m1 3-hydroxybutyrate m2 3-hydroxybutyrate m3 3-hydroxybutyrate m4 alanine m0 alanine m1 alanine m2 alanine m3 asparagine m0 asparagine m1 asparagine m2 asparagine m3 asparagine m4 aspartate m0 aspartate m1 aspartate m2 aspartate m3 aspartate m4 citrate m0 citrate m1 citrate m2 citrate m3 citrate m4 citrate m5 citrate m6 fumarate m0 fumarate m1 fumarate m2 fumarate m3 fumarate m4 glucose m0 glucose m1 glucose m2 glucose m3 glucose m4 glutamic acid m0 glutamic acid m1 glutamic acid m2 glutamic acid m3 glutamic acid m4 glutamic acid m5 glutamine m0 glutamine m1 glutamine m2 glutamine m3 glutamine m4 glutamine m5 glycine m0 glycine m1 glycine m2 isoleucine m0 isoleucine m1 isoleucine m2 isoleucine m3 isoleucine m4 isoleucine m5 isoleucine m6 lactic acid m0 lactic acid m1 lactic acid m2 lactic acid m3 leucine m0 leucine m1 leucine m2 leucine m3 leucine m4 leucine m5 leucine m6 lysine m0 lysine m1 lysine m2 lysine m3 lysine m4 lysine m5 lysine m6 malate m0 malate m1 malate m2 malate m3 malate m4 myristate m0 myristate m1 myristate m2 myristate m3 myristate m4 ornithine m0 ornithine m1 ornithine m2 ornithine m3 ornithine m4 ornithine m5 palmitate m0 palmitate m1 palmitate m2 palmitate m3 palmitate m4 phenylalanine m0 phenylalanine m1 phenylalanine m2 phenylalanine m3 phenylalanine m4 phenylalanine m5 phenylalanine m6 phenylalanine m7 phenylalanine m8 phenylalanine m9 proline m0 proline m1 proline m2 proline m3 proline m4 proline m5 pyroglutamate m0 pyroglutamate m1 pyroglutamate m2 pyroglutamate m3 pyroglutamate m4 pyroglutamate m5 pyruvate m0 pyruvate m1 pyruvate m2 pyruvate m3 serine m0 serine m1 serine m2 serine m3 sorbitol m0 sorbitol m1 sorbitol m2 sorbitol m3 sorbitol m4 stearate m0 stearate m1 stearate m2 stearate m3 stearate m4 succinate m0 succinate m1 succinate m2 succinate m3 succinate m4 threonine m0 threonine m1 threonine m2 threonine m3 threonine m4 tyrosine m0 tyrosine m1 tyrosine m2 tyrosine m3 tyrosine m4 tyrosine m5 tyrosine m6 tyrosine m7 tyrosine m8 tyrosine m9 valine m0 valine m1 valine m2 valine m3 valine m4 valine m5 METABOLITES_END #END