#METABOLOMICS WORKBENCH bifarin_20210816_192704_mwtab.txt DATATRACK_ID:2804 STUDY_ID:ST001923 ANALYSIS_ID:AN003125 PROJECT_ID:PR001214
VERSION             	1
CREATED_ON             	October 8, 2021, 9:19 am
#PROJECT
PR:PROJECT_TITLE                 	Urine-Based Metabolomics and Machine Learning Reveals Metabolites Associated
PR:PROJECT_TITLE                 	with Renal Cell Carcinoma Progression
PR:PROJECT_TYPE                  	multi-platform urine-based metabolomics
PR:PROJECT_SUMMARY               	Every year, hundreds of thousands of cases of renal carcinoma (RCC) are reported
PR:PROJECT_SUMMARY               	worldwide. Accurate staging of the disease is important for treatment and
PR:PROJECT_SUMMARY               	prognosis purposes; however, contemporary methods such as computerized
PR:PROJECT_SUMMARY               	tomography (CT) and biopsies are expensive and prone to sampling errors,
PR:PROJECT_SUMMARY               	respectively. As such, a non-invasive diagnostic assay for staging would be
PR:PROJECT_SUMMARY               	beneficial. This study aims to investigate urine metabolites as potential
PR:PROJECT_SUMMARY               	biomarkers to stage RCC. In the study, we identified a panel of such urine
PR:PROJECT_SUMMARY               	metabolites with machine learning techniques.
PR:INSTITUTE                     	University of Georgia
PR:DEPARTMENT                    	Biochemistry and Molecular Biology
PR:LABORATORY                    	Fernandez Lab/ Edison Lab
PR:LAST_NAME                     	Bifarin
PR:FIRST_NAME                    	Olatomiwa
PR:ADDRESS                       	315 Riverbend Rd, Athens, GA 30602
PR:EMAIL                         	olatomiwa.bifarin25@uga.edu
PR:PHONE                         	(706) 542-4401 Lab: 1045
#STUDY
ST:STUDY_TITLE                   	Urine-Based Metabolomics and Machine Learning Reveals Metabolites Associated
ST:STUDY_TITLE                   	with Renal Cell Carcinoma Progression
ST:STUDY_SUMMARY                 	Every year, hundreds of thousands of cases of renal carcinoma (RCC) are reported
ST:STUDY_SUMMARY                 	worldwide. Accurate staging of the disease is important for treatment and
ST:STUDY_SUMMARY                 	prognosis purposes; however, contemporary methods such as computerized
ST:STUDY_SUMMARY                 	tomography (CT) and biopsies are expensive and prone to sampling errors,
ST:STUDY_SUMMARY                 	respectively. As such, a non-invasive diagnostic assay for staging would be
ST:STUDY_SUMMARY                 	beneficial. This study aims to investigate urine metabolites as potential
ST:STUDY_SUMMARY                 	biomarkers to stage RCC. In the study, we identified a panel of such urine
ST:STUDY_SUMMARY                 	metabolites with machine learning techniques.
ST:INSTITUTE                     	University of Georgia
ST:DEPARTMENT                    	Department of Biochemistry and Molecular Biology
ST:LABORATORY                    	Edison Lab
ST:LAST_NAME                     	Bifarin
ST:FIRST_NAME                    	Olatomiwa
ST:ADDRESS                       	315 Riverbend Rd, Athens, GA 30602
ST:EMAIL                         	olatomiwa.bifarin25@uga.edu
ST:PHONE                         	757-405-4379
ST:NUM_GROUPS                    	Two
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
#FACTORS
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	C001	Factor:Early	RAW_FILE_NAME=C001; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=24.4; Age=38.1; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=2.9
SUBJECT_SAMPLE_FACTORS           	-	C002	Factor:Unknown	RAW_FILE_NAME=C002; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=30.6; Age=64.9; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=Unknown; Tumor Width=3
SUBJECT_SAMPLE_FACTORS           	-	C003	Factor:Unknown	RAW_FILE_NAME=C003; Sample description=Chromophobe carcinoma; Gender=Male; Race=White; Smoker=Never; BMI=34.2; Age=64; Metastatic=No; SubTypes=Chromophobe; Nuclear Grade=Unknown; Grade=Unknown; Stage=Unknown; Tumor Width=5.5
SUBJECT_SAMPLE_FACTORS           	-	C004	Factor:Unknown	RAW_FILE_NAME=C004; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=24.7; Age=84.8; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=Unknown; Tumor Width=4.7
SUBJECT_SAMPLE_FACTORS           	-	C005	Factor:Unknown	RAW_FILE_NAME=C005; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Former; BMI=32.2; Age=55.7; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=Unknown; Tumor Width=2.4
SUBJECT_SAMPLE_FACTORS           	-	C006	Factor:Unknown	RAW_FILE_NAME=C006; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=27.8; Age=59; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=Unknown; Tumor Width=2
SUBJECT_SAMPLE_FACTORS           	-	C007	Factor:Unknown	RAW_FILE_NAME=C007; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=32.2; Age=44.7; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=Unknown; Tumor Width=4
SUBJECT_SAMPLE_FACTORS           	-	C009	Factor:Early	RAW_FILE_NAME=C009; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=27.2; Age=50.8; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=2; Tumor Width=10.1
SUBJECT_SAMPLE_FACTORS           	-	C011	Factor:Late	RAW_FILE_NAME=C011; Sample description=Sarcomatoid; Gender=Female; Race=White; Smoker=Never; BMI=23.9; Age=74.5; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=9.4
SUBJECT_SAMPLE_FACTORS           	-	C012	Factor:Early	RAW_FILE_NAME=C012; Sample description=Papillary RCC; Gender=Male; Race=White; Smoker=Former; BMI=27.2; Age=77.4; Metastatic=No; SubTypes=Papillary; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=4.3
SUBJECT_SAMPLE_FACTORS           	-	C013	Factor:Early	RAW_FILE_NAME=C013; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=American-Indian/Alaskan-Native; Smoker=Never; BMI=25; Age=46.2; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=3.9
SUBJECT_SAMPLE_FACTORS           	-	C014	Factor:Late	RAW_FILE_NAME=C014; Sample description=Sarcomatoid; Gender=Male; Race=White; Smoker=Never; BMI=35.4; Age=60.9; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=10.3
SUBJECT_SAMPLE_FACTORS           	-	C015	Factor:Late	RAW_FILE_NAME=C015; Sample description=Sarcomatoid; Gender=Male; Race=White; Smoker=Never; BMI=21.8; Age=45.2; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=12.4
SUBJECT_SAMPLE_FACTORS           	-	C016	Factor:Early	RAW_FILE_NAME=C016; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Current; BMI=32.5; Age=35.1; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=3.5
SUBJECT_SAMPLE_FACTORS           	-	C018	Factor:Early	RAW_FILE_NAME=C018; Sample description=Chromophobe carcinoma; Gender=Female; Race=Black/AA; Smoker=Never; BMI=24.9; Age=56; Metastatic=No; SubTypes=Chromophobe; Nuclear Grade=3; Grade=High; Stage=2; Tumor Width=11.5
SUBJECT_SAMPLE_FACTORS           	-	C019	Factor:Late	RAW_FILE_NAME=C019; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=37.3; Age=58.8; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=3; Tumor Width=9.3
SUBJECT_SAMPLE_FACTORS           	-	C020	Factor:Early	RAW_FILE_NAME=C020; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; Smoker=Former; BMI=41; Age=72.9; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=2; Tumor Width=9.5
SUBJECT_SAMPLE_FACTORS           	-	C021	Factor:Late	RAW_FILE_NAME=C021; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Former; BMI=31; Age=76.6; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=9.5
SUBJECT_SAMPLE_FACTORS           	-	C022	Factor:Early	RAW_FILE_NAME=C022; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Former; BMI=38.4; Age=55.1; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=3.3
SUBJECT_SAMPLE_FACTORS           	-	C024	Factor:Early	RAW_FILE_NAME=C024; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=36.4; Age=52.8; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=3.9
SUBJECT_SAMPLE_FACTORS           	-	C025	Factor:Late	RAW_FILE_NAME=C025; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=23.5; Age=67; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=6.7
SUBJECT_SAMPLE_FACTORS           	-	C026	Factor:Late	RAW_FILE_NAME=C026; Sample description=Sarcomatoid; Gender=Female; Race=White; Smoker=Never; BMI=23.9; Age=59.4; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=11.2
SUBJECT_SAMPLE_FACTORS           	-	C027	Factor:Early	RAW_FILE_NAME=C027; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Former; BMI=26.7; Age=55.8; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=2.7
SUBJECT_SAMPLE_FACTORS           	-	C028	Factor:Late	RAW_FILE_NAME=C028; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Former; BMI=31.7; Age=68.8; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=4; Tumor Width=8.5
SUBJECT_SAMPLE_FACTORS           	-	C030	Factor:Late	RAW_FILE_NAME=C030; Sample description=Cancer (Other); Gender=Male; Race=White; Smoker=Current; BMI=18.2; Age=67.7; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=3; Tumor Width=10
SUBJECT_SAMPLE_FACTORS           	-	C031	Factor:Late	RAW_FILE_NAME=C031; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=26.4; Age=69.5; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=3; Tumor Width=5.3
SUBJECT_SAMPLE_FACTORS           	-	C033	Factor:Late	RAW_FILE_NAME=C033; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Unk/Missing; Smoker=Never; BMI=30.2; Age=31; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=3; Tumor Width=15
SUBJECT_SAMPLE_FACTORS           	-	C034	Factor:Unknown	RAW_FILE_NAME=C034; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Former; BMI=28.1; Age=56; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=Unknown; Grade=Unknown; Stage=Unknown; Tumor Width=Unknown
SUBJECT_SAMPLE_FACTORS           	-	C036	Factor:Early	RAW_FILE_NAME=C036; Sample description=Clear Cell Papillary; Gender=Female; Race=Black/AA; Smoker=Never; BMI=37.1; Age=53; Metastatic=No; SubTypes=Clear Cell Papillary; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=2.2
SUBJECT_SAMPLE_FACTORS           	-	C037	Factor:Early	RAW_FILE_NAME=C037; Sample description=Papillary RCC; Gender=Male; Race=Black/AA; Smoker=Never; BMI=31; Age=55.6; Metastatic=No; SubTypes=Papillary; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=3.5
SUBJECT_SAMPLE_FACTORS           	-	C038	Factor:Late	RAW_FILE_NAME=C038; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Former; BMI=34; Age=77.1; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=5.5
SUBJECT_SAMPLE_FACTORS           	-	C039	Factor:Early	RAW_FILE_NAME=C039; Sample description=Chromophobe carcinoma; Gender=Male; Race=White; Smoker=Never; BMI=30; Age=80.1; Metastatic=No; SubTypes=Chromophobe; Nuclear Grade=4; Grade=High; Stage=1; Tumor Width=5.2
SUBJECT_SAMPLE_FACTORS           	-	C040	Factor:Early	RAW_FILE_NAME=C040; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Former; BMI=33.3; Age=62.5; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=4.2
SUBJECT_SAMPLE_FACTORS           	-	C041	Factor:Late	RAW_FILE_NAME=C041; Sample description=Cancer (Other); Gender=Male; Race=White; Smoker=Former; BMI=33.6; Age=65.6; Metastatic=Yes; SubTypes=Unclassified; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=3.5
SUBJECT_SAMPLE_FACTORS           	-	C043	Factor:Late	RAW_FILE_NAME=C043; Sample description=Sarcomatoid; Gender=Female; Race=White; Smoker=Never; BMI=38.5; Age=58.3; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=5.5
SUBJECT_SAMPLE_FACTORS           	-	C044	Factor:Late	RAW_FILE_NAME=C044; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; Smoker=Never; BMI=29.4; Age=66.6; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=12.8
SUBJECT_SAMPLE_FACTORS           	-	C045	Factor:Late	RAW_FILE_NAME=C045; Sample description=Sarcomatoid; Gender=Male; Race=Black/AA; Smoker=Never; BMI=29.5; Age=42.5; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=27
SUBJECT_SAMPLE_FACTORS           	-	C046	Factor:Early	RAW_FILE_NAME=C046; Sample description=Chromophobe carcinoma; Gender=Female; Race=White; Smoker=Former; BMI=27.4; Age=55.4; Metastatic=No; SubTypes=Chromophobe; Nuclear Grade=4; Grade=High; Stage=1; Tumor Width=4.1
SUBJECT_SAMPLE_FACTORS           	-	C047	Factor:Early	RAW_FILE_NAME=C047; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Former; BMI=32.7; Age=82.9; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=4.1
SUBJECT_SAMPLE_FACTORS           	-	C048	Factor:Late	RAW_FILE_NAME=C048; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Former; BMI=31; Age=72.4; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=3; Tumor Width=10.8
SUBJECT_SAMPLE_FACTORS           	-	C049	Factor:Early	RAW_FILE_NAME=C049; Sample description=Sarcomatoid; Gender=Male; Race=White; Smoker=Never; BMI=36.3; Age=64.2; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=1; Tumor Width=5.2
SUBJECT_SAMPLE_FACTORS           	-	C050	Factor:Late	RAW_FILE_NAME=C050; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Asian; Smoker=Never; BMI=15.7; Age=73; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=3; Tumor Width=11.4
SUBJECT_SAMPLE_FACTORS           	-	C051	Factor:Late	RAW_FILE_NAME=C051; Sample description=Cancer (Other); Gender=Male; Race=White; Smoker=Never; BMI=23; Age=30.2; Metastatic=Yes; SubTypes=Unclassified; Nuclear Grade=3; Grade=High; Stage=4; Tumor Width=10.4
SUBJECT_SAMPLE_FACTORS           	-	C052	Factor:Unknown	RAW_FILE_NAME=C052; Sample description=Clear Cell Papillary; Gender=Female; Race=Unk/Missing; Smoker=Former; BMI=45; Age=64.5; Metastatic=No; SubTypes=Clear Cell Papillary; Nuclear Grade=2; Grade=Low; Stage=Unknown; Tumor Width=3.2
SUBJECT_SAMPLE_FACTORS           	-	C053	Factor:Early	RAW_FILE_NAME=C053; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Former; BMI=42.1; Age=68.2; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=5
SUBJECT_SAMPLE_FACTORS           	-	C054	Factor:Early	RAW_FILE_NAME=C054; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=24.4; Age=67.8; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=1.6
SUBJECT_SAMPLE_FACTORS           	-	C057	Factor:Early	RAW_FILE_NAME=C057; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=35.2; Age=60.5; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=1.5
SUBJECT_SAMPLE_FACTORS           	-	C058	Factor:Early	RAW_FILE_NAME=C058; Sample description=Papillary RCC; Gender=Male; Race=Black/AA; Smoker=Former; BMI=24.7; Age=83.7; Metastatic=No; SubTypes=Papillary; Nuclear Grade=3; Grade=High; Stage=2; Tumor Width=8
SUBJECT_SAMPLE_FACTORS           	-	C059	Factor:Late	RAW_FILE_NAME=C059; Sample description=Sarcomatoid; Gender=Male; Race=White; Smoker=Former; BMI=27.7; Age=75.5; Metastatic=No; SubTypes=Papillary; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=5.5
SUBJECT_SAMPLE_FACTORS           	-	C060	Factor:Late	RAW_FILE_NAME=C060; Sample description=Sarcomatoid; Gender=Male; Race=Mixed; Smoker=Never; BMI=24.9; Age=43.3; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=11
SUBJECT_SAMPLE_FACTORS           	-	C061	Factor:Early	RAW_FILE_NAME=C061; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=21.1; Age=47.2; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=3
SUBJECT_SAMPLE_FACTORS           	-	C062	Factor:Early	RAW_FILE_NAME=C062; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=31; Age=76.4; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=2.6
SUBJECT_SAMPLE_FACTORS           	-	C063	Factor:Early	RAW_FILE_NAME=C063; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=25.7; Age=61.9; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=1
SUBJECT_SAMPLE_FACTORS           	-	C064	Factor:Late	RAW_FILE_NAME=C064; Sample description=Sarcomatoid; Gender=Male; Race=White; Smoker=Never; BMI=18.5; Age=55.6; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=4; Tumor Width=5.5
SUBJECT_SAMPLE_FACTORS           	-	C065	Factor:Unknown	RAW_FILE_NAME=C065; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Current; BMI=29.4; Age=67; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=Unknown; Tumor Width=6
SUBJECT_SAMPLE_FACTORS           	-	C066	Factor:Late	RAW_FILE_NAME=C066; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; Smoker=Current; BMI=17.4; Age=56.6; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=6
SUBJECT_SAMPLE_FACTORS           	-	C070	Factor:Early	RAW_FILE_NAME=C070; Sample description=Papillary RCC; Gender=Female; Race=Black/AA; Smoker=Former; BMI=31.3; Age=76.2; Metastatic=No; SubTypes=Papillary; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=3.8
SUBJECT_SAMPLE_FACTORS           	-	C096	Factor:Early	RAW_FILE_NAME=C096; Sample description=Clear Cell Papillary; Gender=Male; Race=Black/AA; Smoker=Never; BMI=21.7; Age=66.3; Metastatic=No; SubTypes=Chromophobe; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=3.5
SUBJECT_SAMPLE_FACTORS           	-	C097	Factor:Late	RAW_FILE_NAME=C097; Sample description=Clear Cell Papillary; Gender=Female; Race=Black/AA; Smoker=Never; BMI=30.5; Age=64.3; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=4; Tumor Width=7.7
SUBJECT_SAMPLE_FACTORS           	-	C099	Factor:Late	RAW_FILE_NAME=C099; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=Black/AA; Smoker=Former; BMI=36.8; Age=58; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=4; Tumor Width=10.2
SUBJECT_SAMPLE_FACTORS           	-	C101	Factor:Early	RAW_FILE_NAME=C101; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; Smoker=Never; BMI=28.5; Age=32.6; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=1.7
SUBJECT_SAMPLE_FACTORS           	-	C102	Factor:Early	RAW_FILE_NAME=C102; Sample description=Papillary RCC; Gender=Female; Race=White; Smoker=Current; BMI=26.3; Age=60.2; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=5
SUBJECT_SAMPLE_FACTORS           	-	C086	Factor:Late	RAW_FILE_NAME=C086; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=26.2; Age=52.3; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=4; Tumor Width=11
SUBJECT_SAMPLE_FACTORS           	-	C083	Factor:Early	RAW_FILE_NAME=C083; Sample description=Cancer (Other); Gender=Male; Race=Black/AA; Smoker=Former; BMI=29; Age=76.7; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=1.4
SUBJECT_SAMPLE_FACTORS           	-	C084	Factor:Early	RAW_FILE_NAME=C084; Sample description=Cancer (Other); Gender=Male; Race=White; Smoker=Never; BMI=30.6; Age=60.4; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=2.1
SUBJECT_SAMPLE_FACTORS           	-	C073	Factor:Late	RAW_FILE_NAME=C073; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=38; Age=62.1; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=4; Grade=High; Stage=3; Tumor Width=18
SUBJECT_SAMPLE_FACTORS           	-	C095	Factor:Early	RAW_FILE_NAME=C095; Sample description=Papillary RCC; Gender=Male; Race=Black/AA; Smoker=Never; BMI=21.7; Age=72.4; Metastatic=No; SubTypes=Clear Cell Papillary; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=1
SUBJECT_SAMPLE_FACTORS           	-	C074	Factor:Unknown	RAW_FILE_NAME=C074; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Never; BMI=31; Age=74.9; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=-; Tumor Width=8.4
SUBJECT_SAMPLE_FACTORS           	-	C076	Factor:Unknown	RAW_FILE_NAME=C076; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=31; Age=71.7; Metastatic=No; SubTypes=Clear Cell Papillary; Nuclear Grade=Unknown; Grade=Unknown; Stage=Unknown; Tumor Width=Unknown
SUBJECT_SAMPLE_FACTORS           	-	C072	Factor:Late	RAW_FILE_NAME=C072; Sample description=Chromophobe carcinoma; Gender=Female; Race=White; Smoker=Never; BMI=29.7; Age=36.7; Metastatic=Yes; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=4; Tumor Width=2
SUBJECT_SAMPLE_FACTORS           	-	C077	Factor:Early	RAW_FILE_NAME=C077; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Former; BMI=25; Age=69.2; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=2
SUBJECT_SAMPLE_FACTORS           	-	C078	Factor:Late	RAW_FILE_NAME=C078; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=White; Smoker=Former; BMI=25; Age=81.1; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=3; Grade=High; Stage=3; Tumor Width=4.7
SUBJECT_SAMPLE_FACTORS           	-	C079	Factor:Unknown	RAW_FILE_NAME=C079; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; Smoker=Never; BMI=29; Age=45.8; Metastatic=No; SubTypes=Unclassified; Nuclear Grade=Unknown; Grade=Unknown; Stage=Unknown; Tumor Width=2
SUBJECT_SAMPLE_FACTORS           	-	C085	Factor:Early	RAW_FILE_NAME=C085; Sample description=Cancer (Other); Gender=-; Race=-; Smoker=Never; BMI=21.5; Age=80; Metastatic=No; SubTypes=Papillary; Nuclear Grade=3; Grade=High; Stage=1; Tumor Width=2.5
SUBJECT_SAMPLE_FACTORS           	-	C091	Factor:Early	RAW_FILE_NAME=C091; Sample description=Papillary RCC; Gender=Female; Race=White; Smoker=Current; BMI=31.6; Age=61.6; Metastatic=No; SubTypes=Papillary; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=5.5
SUBJECT_SAMPLE_FACTORS           	-	C087	Factor:Early	RAW_FILE_NAME=C087; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; Smoker=Current; BMI=23.6; Age=60.3; Metastatic=No; SubTypes=Papillary; Nuclear Grade=2; Grade=Low; Stage=2; Tumor Width=10
SUBJECT_SAMPLE_FACTORS           	-	C089	Factor:Early	RAW_FILE_NAME=C089; Sample description=Cancer (Other); Gender=Female; Race=Black/AA; Smoker=Never; BMI=30; Age=39.7; Metastatic=No; SubTypes=Papillary; Nuclear Grade=3; Grade=High; Stage=2; Tumor Width=10.6
SUBJECT_SAMPLE_FACTORS           	-	C081	Factor:Early	RAW_FILE_NAME=C081; Sample description=Pure Clear Cell Cancer; Gender=Female; Race=White; Smoker=Never; BMI=30.9; Age=61.2; Metastatic=No; SubTypes=Clear Cell Papillary; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=2.2
SUBJECT_SAMPLE_FACTORS           	-	C082	Factor:Early	RAW_FILE_NAME=C082; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; Smoker=Never; BMI=30.7; Age=59.8; Metastatic=No; SubTypes=Clear Cell Papillary; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=3.9
SUBJECT_SAMPLE_FACTORS           	-	C092	Factor:Early	RAW_FILE_NAME=C092; Sample description=Papillary RCC; Gender=Male; Race=White; Smoker=Never; BMI=31; Age=38.2; Metastatic=No; SubTypes=Pure Clear Cell; Nuclear Grade=2; Grade=Low; Stage=2; Tumor Width=8.2
SUBJECT_SAMPLE_FACTORS           	-	C093	Factor:Early	RAW_FILE_NAME=C093; Sample description=Papillary RCC; Gender=Female; Race=White; Smoker=Never; BMI=34.6; Age=53.7; Metastatic=No; SubTypes=Unclassified; Nuclear Grade=3; Grade=High; Stage=2; Tumor Width=8.2
SUBJECT_SAMPLE_FACTORS           	-	C088	Factor:Early	RAW_FILE_NAME=C088; Sample description=Pure Clear Cell Cancer; Gender=Male; Race=Black/AA; Smoker=Former; BMI=31.4; Age=62.3; Metastatic=No; SubTypes=Papillary; Nuclear Grade=2; Grade=Low; Stage=1; Tumor Width=2.2
#COLLECTION
CO:COLLECTION_SUMMARY            	Urine samples were collected at the Emory University Hospital
CO:COLLECTION_PROTOCOL_FILENAME  	2_Collection_protocol_RCC_AUG2021.docx
CO:SAMPLE_TYPE                   	Urine
#TREATMENT
TR:TREATMENT_SUMMARY             	There were no treatment in the study, urine samples of healthy subjects and
TR:TREATMENT_SUMMARY             	renal cell carcinoma patients were collected.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Urine’s samples were prepared for both NMR and MS experiments
SP:SAMPLEPREP_PROTOCOL_FILENAME  	3_Sample preparation protocol_RCC_AUG2021.docx
SP:PROCESSING_STORAGE_CONDITIONS 	-80℃
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	Q Exactive HF
CH:COLUMN_NAME                   	Waters Acquity UPLC BEH HILIC (2.1 x 75 mm, 1.7 µm)
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
AN:LABORATORY_NAME               	Fernandez Lab (Georgia Tech)
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive HF hybrid Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	--
MS:MS_RESULTS_FILE               	ST001923_AN003125_Results.txt	UNITS:AU	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END