#METABOLOMICS WORKBENCH cmartias_20210927_020504_mwtab.txt DATATRACK_ID:2868 STUDY_ID:ST001969 ANALYSIS_ID:AN003210 PROJECT_ID:000000 VERSION 1 CREATED_ON September 27, 2021, 2:27 am #PROJECT PR:PROJECT_TITLE Analytical methodology for a metabolome atlas of goat’s plas-ma, milk and PR:PROJECT_TITLE feces using 1H-NMR and UHPLC-HRMS PR:PROJECT_SUMMARY Metabolomics has been increasingly used in animal and food sciences. Animal PR:PROJECT_SUMMARY health is one of the most important factor that can also alter animal integrity PR:PROJECT_SUMMARY and welfare. Some studies have al-ready investigated the link between health and PR:PROJECT_SUMMARY metabolic profile of dairy animals. These studies in metabolomics often consider PR:PROJECT_SUMMARY a single type of sample using a single analytical platform (Nu-clear Magnetic PR:PROJECT_SUMMARY Resonance or Mass Spectrometry). Only few studies with multi-platform PR:PROJECT_SUMMARY ap-proaches are also used with a single or a multi type of sample, but they PR:PROJECT_SUMMARY mainly consider dairy cows metabolome although dairy goats present similar PR:PROJECT_SUMMARY diseases, that it could be interesting to detect early to preserve animal health PR:PROJECT_SUMMARY and milk production. This study aims to create a metabol-ic atlas of goat PR:PROJECT_SUMMARY plasma, milk and feces, based on healthy animals. Our study describes a Standard PR:PROJECT_SUMMARY Operating Procedure for three goat matrices: blood plasma, milk, and feces using PR:PROJECT_SUMMARY multiple plat-forms (NMR (1H), UHPLC (RP)-MS and UHPLC (HILIC)-MS) that follows PR:PROJECT_SUMMARY a unique sample prep-aration procedure for each sample type to be analyzed on PR:PROJECT_SUMMARY multi-platforms basis. Our method was evaluated for its robustness and allowed a PR:PROJECT_SUMMARY better characterization of goat metabolic profile in healthy conditions. PR:INSTITUTE INSERM PR:DEPARTMENT INSERM PR:LAST_NAME Martias PR:FIRST_NAME Cecile PR:ADDRESS 10 Boulevard tonnelé PR:EMAIL cecile.martias@univ-tours.fr PR:PHONE 0247366351 #STUDY ST:STUDY_TITLE Analytical methodology for a metabolome atlas of goat’s plas-ma, milk and ST:STUDY_TITLE feces using 1H-NMR and UHPLC-HRMS ST:STUDY_SUMMARY Metabolomics has been increasingly used in animal and food sciences. Animal ST:STUDY_SUMMARY health is one of the most important factor that can also alter animal integrity ST:STUDY_SUMMARY and welfare. Some studies have al-ready investigated the link between health and ST:STUDY_SUMMARY metabolic profile of dairy animals. These studies in metabolomics often consider ST:STUDY_SUMMARY a single type of sample using a single analytical platform (Nu-clear Magnetic ST:STUDY_SUMMARY Resonance or Mass Spectrometry). Only few studies with multi-platform ST:STUDY_SUMMARY ap-proaches are also used with a single or a multi type of sample, but they ST:STUDY_SUMMARY mainly consider dairy cows metabolome although dairy goats present similar ST:STUDY_SUMMARY diseases, that it could be interesting to detect early to preserve animal health ST:STUDY_SUMMARY and milk production. This study aims to create a metabol-ic atlas of goat ST:STUDY_SUMMARY plasma, milk and feces, based on healthy animals. Our study describes a Standard ST:STUDY_SUMMARY Operating Procedure for three goat matrices: blood plasma, milk, and feces using ST:STUDY_SUMMARY multiple plat-forms (NMR (1H), UHPLC (RP)-MS and UHPLC (HILIC)-MS) that follows ST:STUDY_SUMMARY a unique sample prep-aration procedure for each sample type to be analyzed on ST:STUDY_SUMMARY multi-platforms basis. Our method was evaluated for its robustness and allowed a ST:STUDY_SUMMARY better characterization of goat metabolic profile in healthy conditions. ST:INSTITUTE INSERM ST:DEPARTMENT INSERM ST:LAST_NAME Martias ST:FIRST_NAME Cecile ST:ADDRESS 10 Boulevard tonnelé ST:EMAIL cecile.martias@univ-tours.fr ST:PHONE 0247366351 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Goat #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - L_200_P1_1 Protocole:P1 RAW_FILE_NAME=L_200_P1_1 SUBJECT_SAMPLE_FACTORS - L_200_P1_2 Protocole:P1 RAW_FILE_NAME=L_200_P1_2 SUBJECT_SAMPLE_FACTORS - L_200_P1_3 Protocole:P1 RAW_FILE_NAME=L_200_P1_3 SUBJECT_SAMPLE_FACTORS - L_200_P1_4 Protocole:P1 RAW_FILE_NAME=L_200_P1_4 SUBJECT_SAMPLE_FACTORS - L_200_P1_5 Protocole:P1 RAW_FILE_NAME=L_200_P1_5 SUBJECT_SAMPLE_FACTORS - L_200_P1_6 Protocole:P1 RAW_FILE_NAME=L_200_P1_6 SUBJECT_SAMPLE_FACTORS - L_200_P1_7 Protocole:P1 RAW_FILE_NAME=L_200_P1_7 SUBJECT_SAMPLE_FACTORS - L_200_P1_8 Protocole:P1 RAW_FILE_NAME=L_200_P1_8 SUBJECT_SAMPLE_FACTORS - L_200_P1_9 Protocole:P1 RAW_FILE_NAME=L_200_P1_9 SUBJECT_SAMPLE_FACTORS - L_200_P1_10 Protocole:P1 RAW_FILE_NAME=L_200_P1_10 SUBJECT_SAMPLE_FACTORS - L_200_P3_1 Protocole:P3 RAW_FILE_NAME=L_200_P3_1 SUBJECT_SAMPLE_FACTORS - L_200_P3_2 Protocole:P3 RAW_FILE_NAME=L_200_P3_2 SUBJECT_SAMPLE_FACTORS - L_200_P3_3 Protocole:P3 RAW_FILE_NAME=L_200_P3_3 SUBJECT_SAMPLE_FACTORS - L_200_P3_4 Protocole:P3 RAW_FILE_NAME=L_200_P3_4 SUBJECT_SAMPLE_FACTORS - L_200_P3_5 Protocole:P3 RAW_FILE_NAME=L_200_P3_5 SUBJECT_SAMPLE_FACTORS - L_200_P3_6 Protocole:P3 RAW_FILE_NAME=L_200_P3_6 SUBJECT_SAMPLE_FACTORS - L_200_P3_7 Protocole:P3 RAW_FILE_NAME=L_200_P3_7 SUBJECT_SAMPLE_FACTORS - L_200_P3_8 Protocole:P3 RAW_FILE_NAME=L_200_P3_8 SUBJECT_SAMPLE_FACTORS - L_200_P3_9 Protocole:P3 RAW_FILE_NAME=L_200_P3_9 SUBJECT_SAMPLE_FACTORS - L_200_P3_10 Protocole:p3 RAW_FILE_NAME=L_200_P3_10 SUBJECT_SAMPLE_FACTORS - L_100_P4_1 Protocole:P4 RAW_FILE_NAME=L_100_P4_1 SUBJECT_SAMPLE_FACTORS - L_100_P4_2 Protocole:P4 RAW_FILE_NAME=L_100_P4_2 SUBJECT_SAMPLE_FACTORS - L_100_P4_3 Protocole:P4 RAW_FILE_NAME=L_100_P4_3 SUBJECT_SAMPLE_FACTORS - L_100_P4_4 Protocole:P4 RAW_FILE_NAME=L_100_P4_4 SUBJECT_SAMPLE_FACTORS - L_100_P4_5 Protocole:P4 RAW_FILE_NAME=L_100_P4_5 SUBJECT_SAMPLE_FACTORS - L_100_P4_6 Protocole:P4 RAW_FILE_NAME=L_100_P4_6 SUBJECT_SAMPLE_FACTORS - L_100_P4_7 Protocole:P4 RAW_FILE_NAME=L_100_P4_7 SUBJECT_SAMPLE_FACTORS - L_100_P4_8 Protocole:P4 RAW_FILE_NAME=L_100_P4_8 SUBJECT_SAMPLE_FACTORS - L_100_P4_9 Protocole:P4 RAW_FILE_NAME=L_100_P4_9 SUBJECT_SAMPLE_FACTORS - L_100_P4_10 Protocole:P4 RAW_FILE_NAME=L_100_P4_10 #COLLECTION CO:COLLECTION_SUMMARY Development method for the best sample preparation for goat feces CO:SAMPLE_TYPE Feces #TREATMENT TR:TREATMENT_SUMMARY 5 sample preparation were tested : P1 : Milk:MEOH:CHCL3 1:1:1 , P3: TR:TREATMENT_SUMMARY Milk:MeOH:H2O:CHCl3 1:2.5:2.5, P4: Milk:H2O:MeOH:CHCl3 1:3:4:6 #SAMPLEPREP SP:SAMPLEPREP_SUMMARY - #ANALYSIS AN:ANALYSIS_TYPE NMR #NMR NM:INSTRUMENT_NAME Avance III HD 600 MHz NM:INSTRUMENT_TYPE FT-NMR NM:NMR_EXPERIMENT_TYPE 1D-1H NM:SPECTROMETER_FREQUENCY 600MHz #NMR_METABOLITE_DATA NMR_METABOLITE_DATA:UNITS SI NMR_METABOLITE_DATA_START Samples L_200_P1_1 L_200_P1_2 L_200_P1_3 L_200_P1_4 L_200_P1_5 L_200_P1_6 L_200_P1_7 L_200_P1_8 L_200_P1_9 L_200_P1_10 L_200_P3_1 L_200_P3_2 L_200_P3_3 L_200_P3_4 L_200_P3_5 L_200_P3_6 L_200_P3_7 L_200_P3_8 L_200_P3_9 L_200_P3_10 L_100_P4_1 L_100_P4_2 L_100_P4_3 L_100_P4_4 L_100_P4_5 L_100_P4_6 L_100_P4_7 L_100_P4_8 L_100_P4_9 L_100_P4_10 Factors Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P1 Protocole:P3 Protocole:P3 Protocole:P3 Protocole:P3 Protocole:P3 Protocole:P3 Protocole:P3 Protocole:P3 Protocole:P3 Protocole:p3 Protocole:P4 Protocole:P4 Protocole:P4 Protocole:P4 Protocole:P4 Protocole:P4 Protocole:P4 Protocole:P4 Protocole:P4 Protocole:P4 Oxoglutaric acid 1403877447 1436541819 1607887512 1599202087 1371624077 1334645107 1277795139 1654206297 1327446704 1161611791 1708096224 1698052384 1510306404 1393111642 1422921643 1440401741 1498508907 904382093 1357959638 147865791 4085205374 4983758213 2187735523 4373893113 4468855327 5731149339 4760974967 4670398679 3-Hydroxybutyric acid 5793996046 5922992204 586929854 5281621039 4907958077 518225585 5223614312 5190689179 5190340786 5221074385 5818211852 5631763968 5173022221 5366686782 5576072933 5419166438 6028989582 3599122822 5671291358 5455526029 (S)-3-Hydroxyisobutyric acid 0646300613 048087936 0605626607 0592462123 0448259961 0482535618 0467162069 0509929444 0394552881 0705583729 0469412141 0391613557 0335603923 0465168108 0405683794 0343828851 0368589051 031013279 0473009694 0481465268 1536191395 1385863059 1302207472 1675622176 149141843 2087048389 1721710327 1603334089 Acetamide 3053192991 326173183 3086655389 2778473614 2503844252 2685709181 2710140982 2867766346 2769886083 2547013769 2420648125 237276133 2234829226 2196223057 2225746215 2254300555 2509016072 1516334201 2228774538 2349252723 0920716904 095303549 0850488168 1070700063 0969143161 1214280462 1076469347 099520361 Acetic acid 5433653255 5942298919 571835747 5947230185 5635013905 5442526275 623212818 5998133897 5853923743 5619992769 6412438414 6474022769 7149463717 6595605873 6495349552 6135929555 6914095033 3604441367 5974234004 6874014901 328331146 3349608845 3134845957 3217732324 3125880481 3592664935 3321742388 3168955167 Acetoacetic acid 274076559 291527043 2924819205 2533912111 2242426911 2253058648 222113193 2542076754 2299710542 209661861 2534472255 2628464561 24493721 2461239687 2385235936 240761465 2716310912 1517299886 2325308147 2450525092 0673588592 0800233366 05468979 0784082049 0751291651 1311270314 0758031431 0690469797 L-Acetylcarnitine 8785443563 9606182561 971178607 9204100921 8686023111 8918681791 9039970691 9751238192 9407083526 8497542003 7900214821 8111879285 7809637504 766259021 7893461463 7736864874 8621537393 4711182823 7490503346 7940257076 4142481736 4304594174 3625434388 4124409242 4018780887 4524548427 4240831877 4196728098 Alpha-D-Glucose 179817317 1978006693 2232033498 2096276288 1857177355 212944281 1751424563 2263621131 1900132258 1587469141 1751358655 1785569162 1729140769 1533628849 1545617798 1524522212 1689526689 9505749945 1465137547 1719135344 7886662834 8477283045 5119449622 8109599486 8140223885 9763008206 8022873942 8550116978 Beta-Alanine 8104266842 823223369 8154102522 7615813231 7195962859 7420187659 7374935775 7807434827 7830262187 723188004 7920424465 7822631307 7302914783 7380012892 7547710176 7531787829 8383303713 4797764979 7666464731 7611436605 2801586663 2842260648 2331598615 2813737982 2690089511 3578436132 3002162927 290838701 Choline 3222353495 3560273872 3914860731 359041146 3279371848 4172753427 3320113496 3790693725 3403588555 3092807839 3070233551 3189612374 3023875944 2856839151 2964863963 2983578034 3236537337 1803124851 2803960322 3227855085 1499481657 1618014777 1166643788 1531844117 1462885526 1754955909 1535128033 1563277881 Citric acid 4562239044 5063136396 5122668505 4747508175 4518687621 4912204221 478874443 500840651 5080647793 4581874463 3673517299 3715857569 3668815399 3646154178 378661187 362962989 4128769702 226038696 3592894684 3797337215 2773068348 2808982724 1959105601 2408064093 2164512148 2619225769 2202566061 2549275918 Creatine 4143831985 4435811209 4584542062 40785154 3976909453 4471008089 415577076 4465399099 4577339808 391656655 3790588135 3684280886 3510204487 3594214744 3612571649 3543791254 3938376004 2190403862 3476470289 3527668155 1943856403 1959624548 1705951299 1902431762 1841321458 2045019555 1921156015 200402277 Phosphocreatine 5823085902 64274049 6193354044 6026433326 5752379017 5771274346 610036636 6307920108 6235548818 5795331668 508475882 5180668265 5112892769 4998462087 5292897373 5063792003 5722744624 3151528417 4997694619 5313077337 2888890096 2923862708 2496542811 2834554283 2691549315 3089307637 2750735453 2768767312 Dimethyl sulfone 7344437591 7727444752 8138170821 7855300792 7417580197 744944209 7544416401 847710101 7964493568 7078126068 4237616853 4383532857 412308961 3988595285 4036414077 4097261758 4538756737 2461600745 3917350211 4370670768 3371965814 3512507601 2875615586 3249579521 2912577971 3424763186 3015081477 2989431973 Dimethylamine 2033500853 2190685355 2235968745 2203376852 2039088067 1951205956 2069018843 2282915692 2091770122 1856386685 1299647524 1375425634 1336289475 1196704701 1269262999 1309384455 1434306507 0780683915 1220525367 1400065207 0829128117 0915431573 0718138195 0871530235 0769562708 0986819331 0778279572 0807928884 Formic acid 138198662 1358534588 0942932716 1654578673 1109570146 0980845553 0995016634 1553679037 1393203604 1457295492 1291589462 1549611067 136441961 1289284358 1322060111 1195925166 151228943 0739799264 1366169805 1799433375 0724795005 0767314516 0533517969 0543616577 0623251965 0808500879 0683044758 0749706561 Fumaric acid 1500160331 1840686361 1668741048 1587211314 1503235391 1365580708 172681002 1555711315 1765110914 148181211 1670161782 167622196 1631340438 1632596763 1704507357 1644772492 1830549125 1003101263 1643953619 1900655719 0653968304 0795869379 0421955044 0664343422 0671370912 074553592 0805388257 077545547 Hippuric acid 1882207235 2078003465 204449708 1907258939 183747847 1952129369 1963434992 2032001697 2049414626 1876118044 27897 2821492288 2399906058 2598674654 2980064741 2690613793 3243529338 1754988516 291691798 4115291441 9361622657 9415778834 8217294495 941394898 9154273462 1350119817 9483331089 915721892 Inosine 4058058991 5041208293 3959363656 3826668129 3878955644 4059903314 4068139536 40208547 4354068468 4214489963 1648986101 1740841407 1587704491 1601628315 1425481021 148508188 1649072619 1012076277 1627745352 1471827135 2849115129 2937091111 185214506 2658008411 2461633646 2895330389 2430513435 2884176425 L-Isoleucine 172459257 1327925458 1528499045 1241955057 1179299776 1145108452 1067117669 1155920227 1103811567 1666681969 1906163701 1994990432 2386122175 1671321774 1858980654 1948870596 2094171931 1255141265 195721726 1766428738 1014684104 1026080301 764949569 9383659778 8043448169 11415382 8312647955 9537067123 L-Lactic acid 2029878658 1911961906 1484941943 1238704123 162978003 1723757657 1847246014 2177457152 2302661591 1594672105 8620375576 8563612764 8364756635 8390666947 8769097507 8382078786 9458024574 5044892713 8284548052 8543788595 4587818969 4565138573 4273894488 4535876443 4412136322 4864374294 4554778802 4544533302 Lactose 9574836759 1045283619 1032230987 9544792422 9278246848 1000696313 9904541073 1014560849 1040995674 9408690317 1034845267 1046111795 1100980314 9963170458 1064676022 1036330735 1206651957 6826541066 1039611186 1076956143 5983175662 5910364927 5253615443 5565483488 5239413866 6013002659 5658995787 5664050171 myo-Inositol 1083202906 1247438861 1173517704 1090963418 1131300642 1111567748 1249006034 1204532113 1207458306 1123932579 2320985625 25108511 2340890433 1975828554 2134233955 2118219578 2335088734 1293112493 1977509139 235615516 0896161331 1089000801 0611887615 1007789426 091473816 1207014184 0956882744 1019513927 N-Methylhydantoin 243605534 2645854511 2892404655 2918432141 2539424045 2375791047 2351924865 3077761888 2428649322 2158813552 7054829058 6751790593 6328030767 6464326652 6788983635 6485542422 6994821935 4028069426 6529014039 8085303032 3040656678 3037010906 2332532144 307249474 3064161801 3737023042 2919059158 2827620955 Phenylacetylglycine 6733986314 6985983353 7209428279 6755758439 6336621272 6822650486 6995421405 7205660528 7109081309 6374519672 1737066366 1718759693 165060864 1532612672 1544621842 1515951606 1679707588 0923258768 1411076736 1703563355 0862131649 0899098861 0510371467 0805731786 0746083096 0943942655 0779625406 102017495 Orotic acid 6140576762 734906038 5904110458 5876086975 5840859334 5824698791 6313402561 6268979244 6757783877 5632289172 4584820563 4667859263 4791781185 4980654835 5022866098 474302771 5584752473 2944604827 4910632272 55880947 2856125061 262775007 2244946483 2645390303 2687451956 2913471202 2746546564 2955289389 Phosphorylcholine 5781394978 6292051076 62413486 5765158457 5603965316 6040759225 5933242032 6188490205 6308023437 5618032641 5189687666 5129772874 4989328454 5006173819 5149700348 4991852407 5600960901 3083017814 491421162 5011472656 278080598 2762503802 2529451333 2746055974 2652132867 2953635381 2694087163 2746456373 Succinic acid 8346118234 9098366476 8269860089 7952936068 789278987 7896325267 8463530286 8432360014 8440446218 7710762755 7813815879 8044803168 7762310243 7630344632 7897537773 782649776 9058962522 5002435431 809395206 8466194799 3806024273 3852804273 3472191889 387248335 3663206442 4204494353 3868760142 3765857831 Taurine 9896605293 1412694212 1650934135 100977456 1070694814 1194234321 1034372738 9719291294 1071476149 1079198296 1164303276 9401250619 8869170468 7581975557 8420116722 9372645389 1011821993 4843364258 8971774911 9927577841 4531466213 5135657409 443333942 4478824021 4538318147 4564757562 4547294695 445492906 trans-Aconitic acid 2547390288 4151799962 2083902729 2071668393 245061135 2157202638 2621086725 1966083651 274334506 2671610519 1310410452 1760109712 1549967829 1782621234 239395487 1764186934 208931889 1164015622 2021538277 2737251955 1114332043 1064641252 0411034377 0821451887 1121366161 0934104264 0626799868 0909673462 Uridine 7674837756 9721194951 7532638589 6834565687 7299097821 8144804726 7740075952 7609349878 8186888462 754828422 5638135158 5975136384 4860495888 5199639334 5579945929 5220029177 6439250953 3678441003 5942755041 7447923038 3574142799 3402401631 2668537669 3425129609 3051637207 3599419896 3602646627 3261176089 Uridine diphosphategalactose 3484254358 4178654149 3689625815 340903455 3368038804 3615896515 3673878527 3507265493 3803992895 3511102076 3010326979 2983798983 2991495277 2958725265 3153254212 2975978104 3428757476 1879303379 2962258198 3139837825 166742823 1588740324 1361753635 157395023 1510664239 1671731823 1552059813 1621397569 Uridine diphosphate glucose 2330160014 2812498426 2331979434 2234059377 2183314687 2376103826 2421738151 2326286257 2507732812 2309005095 1955069198 1970594431 1881993115 1950141483 2040480522 1902416996 2219690501 1223159942 1924495634 2076119841 105433623 1035285616 8940182896 1008648102 1015117792 1150068091 1015685788 1009431399 Uridine diphosphate-N-acetylglucosamine 3241501695 35390314 3546946479 3350610099 3178972106 3183102748 3430947798 3414501599 3446273467 3263438675 297335456 2934871463 296782435 2862841865 3108112467 2903519622 3293940653 1880939367 2858408653 3103823175 1544276833 1544562047 1439116262 1572090257 1514942658 169814026 1513106873 1568880527 L-Valine 2256358071 2364858302 2147303877 2058230017 197812947 1993311963 1831347761 1969175955 1969331312 2314150552 1975917515 1988811634 19691974 1844504354 1774857213 1998288455 2117614464 1311142114 1970205952 1789093274 NMR_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name HMDB PubChem KEGG Oxoglutaric acid HMDB0000208 51 C00026 3-Hydroxybutyric acid HMDB0000357 441 C01089 (S)-3-Hydroxyisobutyric acid HMDB0000023 87 C06001 Acetamide HMDB0031645 178 C06244 Acetic acid HMDB0000042 176 C00033 Acetoacetic acid HMDB0000060 96 C00164 L-Acetylcarnitine HMDB0000201 7045767 C02571 Alpha-D-Glucose HMDB0003345 79025 C00267 Beta-Alanine HMDB0000056 239 C00099 Choline HMDB0000097 305 C00114 Citric acid HMDB0000094 311 C00158 Creatine HMDB0000064 586 C00300 Phosphocreatine HMDB0001511 587 C02305 Dimethyl sulfone HMDB0004983 6213 C11142 Dimethylamine HMDB0000087 674 C00543 Formic acid HMDB0000142 284 C00058 Fumaric acid HMDB0000134 444972 C00122 Hippuric acid HMDB0000714 464 C01586 Inosine HMDB0000195 6021 C00294 L-Isoleucine HMDB0000172 6306 C00407 L-Lactic acid HMDB0000190 61503 C00186 Lactose HMDB0041627 6134 C01970 myo-Inositol HMDB0000211 NA C00137 N-Methylhydantoin HMDB0003646 69217 C02565 Phenylacetylglycine HMDB0000821 68144 C05598 Orotic acid HMDB0000226 967 C00295 Phosphorylcholine HMDB0001565 8691 C00588 Succinic acid HMDB0000254 1110 C00042 Taurine HMDB0000251 1123 C00245 trans-Aconitic acid HMDB0000958 444212 C02341 Uridine HMDB0000296 6029 C00299 Uridine diphosphategalactose HMDB0000302 18068 C00052 Uridine diphosphate glucose HMDB0000286 53477679 C00029 Uridine diphosphate-N-acetylglucosamine HMDB0000290 9547196 C00043 L-Valine HMDB0000883 6287 C00183 METABOLITES_END #END