#METABOLOMICS WORKBENCH htian_20221003_112913 DATATRACK_ID:3488 STUDY_ID:ST002308 ANALYSIS_ID:AN003770 PROJECT_ID:PR001820 VERSION 1 CREATED_ON October 7, 2022, 1:57 pm #PROJECT PR:PROJECT_TITLE Metabolomics Discovery of Aryl Hydrocarbon Receptor Activating Metabolites from PR:PROJECT_TITLE the Human Microbiota (Targeted) PR:PROJECT_TYPE Bacteria supernatant PR:PROJECT_SUMMARY The aryl hydrocarbon receptor (AhR) is a transcription factor that regulates PR:PROJECT_SUMMARY gene expression upon activation by small molecules. It plays a significant role PR:PROJECT_SUMMARY in the innate immune recognition of bacteria and response to exogenous molecules PR:PROJECT_SUMMARY in the human host. By stimulating host immune cells with microbiota metabolites, PR:PROJECT_SUMMARY the AhR signaling enables microbiota-dependent induction, training, and function PR:PROJECT_SUMMARY of the host immune system. AhR is a potential target for developing therapeutics PR:PROJECT_SUMMARY to treat myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cancer, PR:PROJECT_SUMMARY and aging-related diseases. A variety of bioactive molecules can act as AhR PR:PROJECT_SUMMARY agonists, including the metabolites and derivatives of indole and tryptophan. PR:PROJECT_SUMMARY However, given the ligand-binding versatility of AhR, new methods are needed to PR:PROJECT_SUMMARY discover novel AhR agonists. Herein, we report an analytical workflow for the PR:PROJECT_SUMMARY deep discovery of AhR agonists from the secreted metabolome of bacteria. We also PR:PROJECT_SUMMARY describe a method of targeted discovery of AhR-activating metabolites and report PR:PROJECT_SUMMARY a correlation analysis of the AhR activity with the concentration of endogenous PR:PROJECT_SUMMARY metabolites that identified significant common AhR activators shared by PR:PROJECT_SUMMARY different strains of bacteria in the human microbiome. Principal component PR:PROJECT_SUMMARY analysis of relative concentrations of indole compounds clusters different PR:PROJECT_SUMMARY bacteria species, providing a possible means for evaluating the regulation of PR:PROJECT_SUMMARY the bacteria indole pathway. PR:INSTITUTE University of Connecticut PR:DEPARTMENT Chemistry PR:LABORATORY Yao Lab PR:LAST_NAME Tian PR:FIRST_NAME Huidi PR:ADDRESS 55 N. Eagleville Road, Unit 3060, Storrs CT 06269 PR:EMAIL huidi.tian@uconn.edu PR:PHONE 8606341143 PR:FUNDING_SOURCE NIH-NINDS and NIH-NIAID #STUDY ST:STUDY_TITLE Metabolomics profiling of full extracts and fractions of bacterial culture ST:STUDY_TITLE supernatants. ST:STUDY_TYPE MSMS quantitative analysis ST:STUDY_SUMMARY Targeted quantitation of select indole compounds in supernatant full extracts ST:STUDY_SUMMARY was performed on a quadrupole orbitrap mass spectrometer. ST:INSTITUTE University of Connecticut ST:DEPARTMENT Chemistry ST:LABORATORY Yao Lab ST:LAST_NAME Tian ST:FIRST_NAME Huidi ST:ADDRESS 55 N. Eagleville Road, Unit 3060, Storrs CT 06269 ST:EMAIL huidi.tian@uconn.edu ST:PHONE 8606341143 #SUBJECT SU:SUBJECT_TYPE Bacteria SU:SUBJECT_SPECIES Species specified in the sample list #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - A1_5xC_1 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.669507168; RAW_FILE_NAME=A1_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A1_5xC_2 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.669507168; RAW_FILE_NAME=A1_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A1_5xC_3 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.669507168; RAW_FILE_NAME=A1_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A2_5xC_1 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.602913504; RAW_FILE_NAME=A2_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A2_5xC_2 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.602913504; RAW_FILE_NAME=A2_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A2_5xC_3 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.602913504; RAW_FILE_NAME=A2_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A3_5xC_1 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.60278891; RAW_FILE_NAME=A3_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A3_5xC_2 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.60278891; RAW_FILE_NAME=A3_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A3_5xC_3 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Relative AhR activity=0.60278891; RAW_FILE_NAME=A3_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A4_5xC_1 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.978817032; RAW_FILE_NAME=A4_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A4_5xC_2 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.978817032; RAW_FILE_NAME=A4_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A4_5xC_3 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.978817032; RAW_FILE_NAME=A4_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A5_5xC_1 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.999109483; RAW_FILE_NAME=A5_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A5_5xC_2 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.999109483; RAW_FILE_NAME=A5_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A5_5xC_3 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.999109483; RAW_FILE_NAME=A5_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A6_5xC_1 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.997168314; RAW_FILE_NAME=A6_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A6_5xC_2 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.997168314; RAW_FILE_NAME=A6_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A6_5xC_3 Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Relative AhR activity=0.997168314; RAW_FILE_NAME=A6_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A10_5xC_1 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.565345031; RAW_FILE_NAME=A10_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A10_5xC_2 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.565345031; RAW_FILE_NAME=A10_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A10_5xC_3 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.565345031; RAW_FILE_NAME=A10_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A11_5xC_1 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.503567057; RAW_FILE_NAME=A11_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A11_5xC_2 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.503567057; RAW_FILE_NAME=A11_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A11_5xC_3 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.503567057; RAW_FILE_NAME=A11_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A12_5xC_1 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.551024402; RAW_FILE_NAME=A12_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - A12_5xC_2 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.551024402; RAW_FILE_NAME=A12_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - A12_5xC_3 Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Relative AhR activity=0.551024402; RAW_FILE_NAME=A12_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B1_5xC_1 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.519612747; RAW_FILE_NAME=B1_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B1_5xC_2 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.519612747; RAW_FILE_NAME=B1_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B1_5xC_3 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.519612747; RAW_FILE_NAME=B1_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B2_5xC_1 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.766786317; RAW_FILE_NAME=B2_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B2_5xC_2 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.766786317; RAW_FILE_NAME=B2_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B2_5xC_3 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.766786317; RAW_FILE_NAME=B2_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B3_5xC_1 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.703830729; RAW_FILE_NAME=B3_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B3_5xC_2 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.703830729; RAW_FILE_NAME=B3_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B3_5xC_3 Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Relative AhR activity=0.703830729; RAW_FILE_NAME=B3_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B4_5xC_1 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.747872298; RAW_FILE_NAME=B4_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B4_5xC_2 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.747872298; RAW_FILE_NAME=B4_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B4_5xC_3 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.747872298; RAW_FILE_NAME=B4_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B5_5xC_1 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.65628525; RAW_FILE_NAME=B5_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B5_5xC_2 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.65628525; RAW_FILE_NAME=B5_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B5_5xC_3 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.65628525; RAW_FILE_NAME=B5_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B6_5xC_1 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.776258832; RAW_FILE_NAME=B6_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B6_5xC_2 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.776258832; RAW_FILE_NAME=B6_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B6_5xC_3 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Relative AhR activity=0.776258832; RAW_FILE_NAME=B6_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B7_5xC_1 Bacterial strain:Enterococcus faecium 320 | Concentration:5 times concentrated Relative AhR activity=0.821265504; RAW_FILE_NAME=B7_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B7_5xC_2 Bacterial strain:Enterococcus faecium 321 | Concentration:5 times concentrated Relative AhR activity=0.821265504; RAW_FILE_NAME=B7_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B7_5xC_3 Bacterial strain:Enterococcus faecium 322 | Concentration:5 times concentrated Relative AhR activity=0.821265504; RAW_FILE_NAME=B7_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B8_5xC_1 Bacterial strain:Enterococcus faecium 323 | Concentration:5 times concentrated Relative AhR activity=0.796960702; RAW_FILE_NAME=B8_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B8_5xC_2 Bacterial strain:Enterococcus faecium 324 | Concentration:5 times concentrated Relative AhR activity=0.796960702; RAW_FILE_NAME=B8_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B8_5xC_3 Bacterial strain:Enterococcus faecium 325 | Concentration:5 times concentrated Relative AhR activity=0.796960702; RAW_FILE_NAME=B8_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B9_5xC_1 Bacterial strain:Enterococcus faecium 326 | Concentration:5 times concentrated Relative AhR activity=0.614786295; RAW_FILE_NAME=B9_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B9_5xC_2 Bacterial strain:Enterococcus faecium 327 | Concentration:5 times concentrated Relative AhR activity=0.614786295; RAW_FILE_NAME=B9_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B9_5xC_3 Bacterial strain:Enterococcus faecium 328 | Concentration:5 times concentrated Relative AhR activity=0.614786295; RAW_FILE_NAME=B9_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B10_5xC_1 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.535565169; RAW_FILE_NAME=B10_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B10_5xC_2 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.535565169; RAW_FILE_NAME=B10_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B10_5xC_3 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.535565169; RAW_FILE_NAME=B10_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B11_5xC_1 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.495308816; RAW_FILE_NAME=B11_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B11_5xC_2 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.495308816; RAW_FILE_NAME=B11_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B11_5xC_3 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.495308816; RAW_FILE_NAME=B11_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - B12_5xC_1 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.71117896; RAW_FILE_NAME=B12_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - B12_5xC_2 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.71117896; RAW_FILE_NAME=B12_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - B12_5xC_3 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Relative AhR activity=0.71117896; RAW_FILE_NAME=B12_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C1_5xC_1 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.588494355; RAW_FILE_NAME=C1_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C1_5xC_2 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.588494355; RAW_FILE_NAME=C1_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C1_5xC_3 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.588494355; RAW_FILE_NAME=C1_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C2_5xC_1 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.577003538; RAW_FILE_NAME=C2_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C2_5xC_2 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.577003538; RAW_FILE_NAME=C2_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C2_5xC_3 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.577003538; RAW_FILE_NAME=C2_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C3_5xC_1 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.556626439; RAW_FILE_NAME=C3_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C3_5xC_2 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.556626439; RAW_FILE_NAME=C3_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C3_5xC_3 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Relative AhR activity=0.556626439; RAW_FILE_NAME=C3_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C4_5xC_1 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.657292695; RAW_FILE_NAME=C4_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C4_5xC_2 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.657292695; RAW_FILE_NAME=C4_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C4_5xC_3 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.657292695; RAW_FILE_NAME=C4_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C5_5xC_1 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.624629703; RAW_FILE_NAME=C5_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C5_5xC_2 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.624629703; RAW_FILE_NAME=C5_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C5_5xC_3 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.624629703; RAW_FILE_NAME=C5_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C6_5xC_1 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.605346347; RAW_FILE_NAME=C6_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C6_5xC_2 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.605346347; RAW_FILE_NAME=C6_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C6_5xC_3 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Relative AhR activity=0.605346347; RAW_FILE_NAME=C6_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C7_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.511208565; RAW_FILE_NAME=C7_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C7_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.511208565; RAW_FILE_NAME=C7_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C7_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.511208565; RAW_FILE_NAME=C7_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C8_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.575199185; RAW_FILE_NAME=C8_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C8_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.575199185; RAW_FILE_NAME=C8_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C8_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.575199185; RAW_FILE_NAME=C8_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C9_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.428122868; RAW_FILE_NAME=C9_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C9_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.428122868; RAW_FILE_NAME=C9_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C9_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Relative AhR activity=0.428122868; RAW_FILE_NAME=C9_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C10_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.521452105; RAW_FILE_NAME=C10_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C10_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.521452105; RAW_FILE_NAME=C10_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C10_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.521452105; RAW_FILE_NAME=C10_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C11_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.586488575; RAW_FILE_NAME=C11_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C11_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.586488575; RAW_FILE_NAME=C11_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C11_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.586488575; RAW_FILE_NAME=C11_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - C12_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.552192976; RAW_FILE_NAME=C12_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - C12_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.552192976; RAW_FILE_NAME=C12_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - C12_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Relative AhR activity=0.552192976; RAW_FILE_NAME=C12_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - D1_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.57013768; RAW_FILE_NAME=D1_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - D1_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.57013768; RAW_FILE_NAME=D1_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - D1_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.57013768; RAW_FILE_NAME=D1_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - D2_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.55652246; RAW_FILE_NAME=D2_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - D2_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.55652246; RAW_FILE_NAME=D2_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - D2_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.55652246; RAW_FILE_NAME=D2_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - D3_5xC_1 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.597198151; RAW_FILE_NAME=D3_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - D3_5xC_2 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.597198151; RAW_FILE_NAME=D3_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - D3_5xC_3 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Relative AhR activity=0.597198151; RAW_FILE_NAME=D3_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - D4_5xC_1 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.879118542; RAW_FILE_NAME=D4_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - D4_5xC_2 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.879118542; RAW_FILE_NAME=D4_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - D4_5xC_3 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.879118542; RAW_FILE_NAME=D4_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - D5_5xC_1 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.760167377; RAW_FILE_NAME=D5_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - D5_5xC_2 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.760167377; RAW_FILE_NAME=D5_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - D5_5xC_3 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.760167377; RAW_FILE_NAME=D5_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - D6_5xC_1 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.691596897; RAW_FILE_NAME=D6_5xC_1.mzML SUBJECT_SAMPLE_FACTORS - D6_5xC_2 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.691596897; RAW_FILE_NAME=D6_5xC_2.mzML SUBJECT_SAMPLE_FACTORS - D6_5xC_3 Bacterial strain:TSB control | Concentration:5 times concentrated Relative AhR activity=0.691596897; RAW_FILE_NAME=D6_5xC_3.mzML SUBJECT_SAMPLE_FACTORS - A1_5xD_1 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.669507168; RAW_FILE_NAME=A1_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A1_5xD_2 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.669507168; RAW_FILE_NAME=A1_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A1_5xD_3 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.669507168; RAW_FILE_NAME=A1_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A2_5xD_1 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.602913504; RAW_FILE_NAME=A2_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A2_5xD_2 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.602913504; RAW_FILE_NAME=A2_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A2_5xD_3 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.602913504; RAW_FILE_NAME=A2_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A3_5xD_1 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.60278891; RAW_FILE_NAME=A3_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A3_5xD_2 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.60278891; RAW_FILE_NAME=A3_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A3_5xD_3 Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Relative AhR activity=0.60278891; RAW_FILE_NAME=A3_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A4_5xD_1 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.978817032; RAW_FILE_NAME=A4_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A4_5xD_2 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.978817032; RAW_FILE_NAME=A4_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A4_5xD_3 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.978817032; RAW_FILE_NAME=A4_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A5_5xD_1 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.999109483; RAW_FILE_NAME=A5_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A5_5xD_2 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.999109483; RAW_FILE_NAME=A5_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A5_5xD_3 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.999109483; RAW_FILE_NAME=A5_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A6_5xD_1 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.997168314; RAW_FILE_NAME=A6_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A6_5xD_2 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.997168314; RAW_FILE_NAME=A6_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A6_5xD_3 Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Relative AhR activity=0.997168314; RAW_FILE_NAME=A6_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A10_5xD_1 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.565345031; RAW_FILE_NAME=A10_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A10_5xD_2 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.565345031; RAW_FILE_NAME=A10_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A10_5xD_3 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.565345031; RAW_FILE_NAME=A10_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A11_5xD_1 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.503567057; RAW_FILE_NAME=A11_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A11_5xD_2 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.503567057; RAW_FILE_NAME=A11_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A11_5xD_3 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.503567057; RAW_FILE_NAME=A11_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - A12_5xD_1 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.551024402; RAW_FILE_NAME=A12_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - A12_5xD_2 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.551024402; RAW_FILE_NAME=A12_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - A12_5xD_3 Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Relative AhR activity=0.551024402; RAW_FILE_NAME=A12_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B1_5xD_1 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.519612747; RAW_FILE_NAME=B1_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B1_5xD_2 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.519612747; RAW_FILE_NAME=B1_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B1_5xD_3 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.519612747; RAW_FILE_NAME=B1_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B2_5xD_1 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.766786317; RAW_FILE_NAME=B2_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B2_5xD_2 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.766786317; RAW_FILE_NAME=B2_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B2_5xD_3 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.766786317; RAW_FILE_NAME=B2_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B3_5xD_1 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.703830729; RAW_FILE_NAME=B3_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B3_5xD_2 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.703830729; RAW_FILE_NAME=B3_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B3_5xD_3 Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Relative AhR activity=0.703830729; RAW_FILE_NAME=B3_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B4_5xD_1 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.747872298; RAW_FILE_NAME=B4_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B4_5xD_2 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.747872298; RAW_FILE_NAME=B4_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B4_5xD_3 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.747872298; RAW_FILE_NAME=B4_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B5_5xD_1 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.65628525; RAW_FILE_NAME=B5_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B5_5xD_2 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.65628525; RAW_FILE_NAME=B5_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B5_5xD_3 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.65628525; RAW_FILE_NAME=B5_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B6_5xD_1 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.776258832; RAW_FILE_NAME=B6_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B6_5xD_2 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.776258832; RAW_FILE_NAME=B6_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B6_5xD_3 Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Relative AhR activity=0.776258832; RAW_FILE_NAME=B6_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B7_5xD_1 Bacterial strain:Enterococcus faecium 320 | Concentration:5 times diluted Relative AhR activity=0.821265504; RAW_FILE_NAME=B7_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B7_5xD_2 Bacterial strain:Enterococcus faecium 321 | Concentration:5 times diluted Relative AhR activity=0.821265504; RAW_FILE_NAME=B7_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B7_5xD_3 Bacterial strain:Enterococcus faecium 322 | Concentration:5 times diluted Relative AhR activity=0.821265504; RAW_FILE_NAME=B7_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B8_5xD_1 Bacterial strain:Enterococcus faecium 323 | Concentration:5 times diluted Relative AhR activity=0.796960702; RAW_FILE_NAME=B8_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B8_5xD_2 Bacterial strain:Enterococcus faecium 324 | Concentration:5 times diluted Relative AhR activity=0.796960702; RAW_FILE_NAME=B8_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B8_5xD_3 Bacterial strain:Enterococcus faecium 325 | Concentration:5 times diluted Relative AhR activity=0.796960702; RAW_FILE_NAME=B8_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B9_5xD_1 Bacterial strain:Enterococcus faecium 326 | Concentration:5 times diluted Relative AhR activity=0.614786295; RAW_FILE_NAME=B9_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B9_5xD_2 Bacterial strain:Enterococcus faecium 327 | Concentration:5 times diluted Relative AhR activity=0.614786295; RAW_FILE_NAME=B9_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B9_5xD_3 Bacterial strain:Enterococcus faecium 328 | Concentration:5 times diluted Relative AhR activity=0.614786295; RAW_FILE_NAME=B9_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B10_5xD_1 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.535565169; RAW_FILE_NAME=B10_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B10_5xD_2 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.535565169; RAW_FILE_NAME=B10_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B10_5xD_3 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.535565169; RAW_FILE_NAME=B10_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B11_5xD_1 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.495308816; RAW_FILE_NAME=B11_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B11_5xD_2 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.495308816; RAW_FILE_NAME=B11_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B11_5xD_3 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.495308816; RAW_FILE_NAME=B11_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - B12_5xD_1 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.71117896; RAW_FILE_NAME=B12_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - B12_5xD_2 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.71117896; RAW_FILE_NAME=B12_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - B12_5xD_3 Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Relative AhR activity=0.71117896; RAW_FILE_NAME=B12_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C1_5xD_1 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.588494355; RAW_FILE_NAME=C1_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C1_5xD_2 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.588494355; RAW_FILE_NAME=C1_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C1_5xD_3 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.588494355; RAW_FILE_NAME=C1_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C2_5xD_1 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.577003538; RAW_FILE_NAME=C2_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C2_5xD_2 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.577003538; RAW_FILE_NAME=C2_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C2_5xD_3 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.577003538; RAW_FILE_NAME=C2_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C3_5xD_1 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.556626439; RAW_FILE_NAME=C3_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C3_5xD_2 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.556626439; RAW_FILE_NAME=C3_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C3_5xD_3 Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Relative AhR activity=0.556626439; RAW_FILE_NAME=C3_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C4_5xD_1 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.657292695; RAW_FILE_NAME=C4_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C4_5xD_2 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.657292695; RAW_FILE_NAME=C4_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C4_5xD_3 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.657292695; RAW_FILE_NAME=C4_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C5_5xD_1 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.624629703; RAW_FILE_NAME=C5_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C5_5xD_2 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.624629703; RAW_FILE_NAME=C5_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C5_5xD_3 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.624629703; RAW_FILE_NAME=C5_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C6_5xD_1 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.605346347; RAW_FILE_NAME=C6_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C6_5xD_2 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.605346347; RAW_FILE_NAME=C6_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C6_5xD_3 Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Relative AhR activity=0.605346347; RAW_FILE_NAME=C6_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C7_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.511208565; RAW_FILE_NAME=C7_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C7_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.511208565; RAW_FILE_NAME=C7_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C7_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.511208565; RAW_FILE_NAME=C7_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C8_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.575199185; RAW_FILE_NAME=C8_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C8_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.575199185; RAW_FILE_NAME=C8_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C8_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.575199185; RAW_FILE_NAME=C8_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C9_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.428122868; RAW_FILE_NAME=C9_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C9_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.428122868; RAW_FILE_NAME=C9_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C9_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Relative AhR activity=0.428122868; RAW_FILE_NAME=C9_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C10_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.521452105; RAW_FILE_NAME=C10_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C10_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.521452105; RAW_FILE_NAME=C10_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C10_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.521452105; RAW_FILE_NAME=C10_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C11_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.586488575; RAW_FILE_NAME=C11_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C11_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.586488575; RAW_FILE_NAME=C11_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C11_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.586488575; RAW_FILE_NAME=C11_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - C12_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.552192976; RAW_FILE_NAME=C12_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - C12_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.552192976; RAW_FILE_NAME=C12_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - C12_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Relative AhR activity=0.552192976; RAW_FILE_NAME=C12_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - D1_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.57013768; RAW_FILE_NAME=D1_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - D1_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.57013768; RAW_FILE_NAME=D1_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - D1_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.57013768; RAW_FILE_NAME=D1_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - D2_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.55652246; RAW_FILE_NAME=D2_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - D2_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.55652246; RAW_FILE_NAME=D2_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - D2_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.55652246; RAW_FILE_NAME=D2_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - D3_5xD_1 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.597198151; RAW_FILE_NAME=D3_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - D3_5xD_2 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.597198151; RAW_FILE_NAME=D3_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - D3_5xD_3 Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Relative AhR activity=0.597198151; RAW_FILE_NAME=D3_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - D4_5xD_1 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.879118542; RAW_FILE_NAME=D4_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - D4_5xD_2 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.879118542; RAW_FILE_NAME=D4_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - D4_5xD_3 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.879118542; RAW_FILE_NAME=D4_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - D5_5xD_1 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.760167377; RAW_FILE_NAME=D5_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - D5_5xD_2 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.760167377; RAW_FILE_NAME=D5_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - D5_5xD_3 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.760167377; RAW_FILE_NAME=D5_5xD_3.mzML SUBJECT_SAMPLE_FACTORS - D6_5xD_1 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.691596897; RAW_FILE_NAME=D6_5xD_1.mzML SUBJECT_SAMPLE_FACTORS - D6_5xD_2 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.691596897; RAW_FILE_NAME=D6_5xD_2.mzML SUBJECT_SAMPLE_FACTORS - D6_5xD_3 Bacterial strain:TSB control | Concentration:5 times diluted Relative AhR activity=0.691596897; RAW_FILE_NAME=D6_5xD_3.mzML #COLLECTION CO:COLLECTION_SUMMARY Various strains of bacteria were cultured from the microbiota of either healthy CO:COLLECTION_SUMMARY volunteers or ME/CFS patients at Jackson Laboratory for Genomic Medicine CO:COLLECTION_SUMMARY (Farmington, CT). The derived bacteria were cultured overnight in tryptic soy CO:COLLECTION_SUMMARY broth (TSB) media. Cells were pelleted, and the supernatant was filtered through CO:COLLECTION_SUMMARY a 0.22-micron filter to prepare cell-free culture supernatants. Supernatants CO:COLLECTION_SUMMARY were stored at -80 ℃. CO:SAMPLE_TYPE Bacterial cells CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY 200 µL of MeOH was first pipetted into each column to condition the sorbent. TR:TREATMENT_SUMMARY Columns were then centrifuged for 2 minutes at 110 xg. The procedure was TR:TREATMENT_SUMMARY repeated three times. Second, 200 µL of water was pipetted into each column to TR:TREATMENT_SUMMARY equilibrate the sorbent. Columns were then centrifuged for 2 minutes at 110 xg, TR:TREATMENT_SUMMARY and the procedure was repeated three times. Third, the samples were loaded into TR:TREATMENT_SUMMARY each prepared column. Each loaded column was placed in a new 2-mL centrifuge TR:TREATMENT_SUMMARY tube. Columns were then centrifuged for 2 minutes at 110 xg. Columns were again TR:TREATMENT_SUMMARY centrifuged for 2 minutes at 110 xg. The flow-through was collected as the TR:TREATMENT_SUMMARY fraction FT. Fourth, 200 µL of water was added to each column to wash the TR:TREATMENT_SUMMARY sorbent bed and release very polar metabolites. Each column was placed in a new TR:TREATMENT_SUMMARY 2-mL centrifuge tube. Columns were then centrifuged for 2 minutes at 110 xg. The TR:TREATMENT_SUMMARY wash was collected as fraction W. Fifth, 200 µL of an elution solvent (80% MeCN TR:TREATMENT_SUMMARY in water, v/v) was added to each column. Each column was placed in a new 2-mL TR:TREATMENT_SUMMARY centrifuge tube. Columns were then centrifuged for 2 minutes at 110 xg. The TR:TREATMENT_SUMMARY eluates were collected as fraction E. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Full extracts of different bacteria were spiked with NFK-C13 and desalted by SP:SAMPLEPREP_SUMMARY Targa C18 cartridges. The desalted extracts were dried by a lyophilizer and SP:SAMPLEPREP_SUMMARY reconstituted with water for LC-parallel reaction monitoring (PRM) MS of a panel SP:SAMPLEPREP_SUMMARY of indole compounds. The supernatants were analyzed as 5-time diluted and SP:SAMPLEPREP_SUMMARY 5-times concentrated, compared to the initial supernatants. The spiked NFK-C13 SP:SAMPLEPREP_SUMMARY was 0.5 µM in each sample. SP:PROCESSING_STORAGE_CONDITIONS On ice SP:EXTRACT_STORAGE -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Targeted quantitation of select indole compounds in supernatant full extracts CH:CHROMATOGRAPHY_SUMMARY was performed on a quadrupole orbitrap mass spectrometer (Exploris 480, Thermo CH:CHROMATOGRAPHY_SUMMARY Fisher Scientific) with an H-ESI ionization source in the positive ion mode. The CH:CHROMATOGRAPHY_SUMMARY front-end separation used a reversed-phase column (CORTECS UPLC T3, 2.1 x 150 CH:CHROMATOGRAPHY_SUMMARY mm, 1.6 μm particle size, 0.52 mL of bed volume, Waters). The autosampler CH:CHROMATOGRAPHY_SUMMARY temperature was 4.0 °C, and the column oven temperature was 40.0 °C. The CH:CHROMATOGRAPHY_SUMMARY sample injection volume was 10 µL. The mobile phase flow rate was 300 µL/min. CH:CHROMATOGRAPHY_SUMMARY Solvent A was 0.1 % FA in water, and solvent B was 0.1 % FA in MeCN. The CH:CHROMATOGRAPHY_SUMMARY gradient (% for Solvent B at runtime) method was 1% from -5 to 0 minute for the CH:CHROMATOGRAPHY_SUMMARY equilibration, 1% from 0 to 1 minute, 90% at 15 minutes, 90% from 15.1 to 19 CH:CHROMATOGRAPHY_SUMMARY minutes, and 1% from 19.1 to 20 minutes. CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Vanquish CH:COLUMN_NAME Waters CORTECS UPLC T3 (2.1 x 150 mm, 1.6 μm) CH:FLOW_GRADIENT 90 CH:FLOW_RATE 0.3 mL CH:COLUMN_TEMPERATURE 40 CH:METHODS_FILENAME Chrom.docx #ANALYSIS AN:ANALYSIS_TYPE MS AN:LABORATORY_NAME Yao Lab AN:OPERATOR_NAME Huidi Tian AN:DETECTOR_TYPE orbitrap #MS MS:INSTRUMENT_NAME Thermo Orbitrap Exploris 480 MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS . Major mass spectrometer parameters were 3500 V for the spray voltage, 50 arb MS:MS_COMMENTS for the sheath gas, 10 arb for the aux gas, 1 arb for the sweep gas, 300 ℃ for MS:MS_COMMENTS the ion transfer tube, and 350 ℃ for the vaporizer temperature. In the full MS MS:MS_COMMENTS mode, the orbitrap resolution was 120,000, with a scan range of 100-1000 m/z. MS:MS_COMMENTS The RF lens was 50%, the AGC target was set to standard, the maximum injection MS:MS_COMMENTS time mode was set to auto, and the microscans were set to 1. The data was MS:MS_COMMENTS collected in the profile format. In the parallel reaction monitoring (PRM) mode, MS:MS_COMMENTS the isolation window was set to 0.7 m/z without isolation offset. The collision MS:MS_COMMENTS energy was set to fix; the normalized collision energy for each compound was MS:MS_COMMENTS defined in Table 1. The other settings remain the same as the DDA mode. The PRM MS:MS_COMMENTS acquisition for each compound was scheduled, and the collision energy was MS:MS_COMMENTS optimized. The orbitrap resolution was 15,000, and the scan range mode was auto. MS:MS_COMMENTS The AGC target was set as standard, the maximum injection time mode was set to MS:MS_COMMENTS auto, the intensity threshold was 1e4, the dynamic exclusion was 6 seconds, and MS:MS_COMMENTS the microscans were set to 1. The data was collected in profile mode. The MS:MS_COMMENTS quantitation was achieved with Skyline. The correlation analysis and PCA were MS:MS_COMMENTS processed in R. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS peak area MS_METABOLITE_DATA_START Samples A1_5xC_1 A2_5xC_1 A3_5xC_1 A4_5xC_1 A5_5xC_1 A6_5xC_1 A10_5xC_1 A11_5xC_1 A12_5xC_1 B1_5xC_1 B2_5xC_1 B3_5xC_1 B4_5xC_1 B5_5xC_1 B6_5xC_1 B7_5xC_1 B8_5xC_1 B9_5xC_1 B10_5xC_1 B11_5xC_1 B12_5xC_1 C1_5xC_1 C2_5xC_1 C3_5xC_1 C4_5xC_1 C5_5xC_1 C6_5xC_1 C7_5xC_1 C8_5xC_1 C9_5xC_1 C10_5xC_1 C11_5xC_1 C12_5xC_1 D1_5xC_1 D2_5xC_1 D3_5xC_1 D4_5xC_1 D5_5xC_1 D6_5xC_1 A1_5xC_2 A2_5xC_2 A3_5xC_2 A4_5xC_2 A5_5xC_2 A6_5xC_2 A10_5xC_2 A11_5xC_2 A12_5xC_2 B1_5xC_2 B2_5xC_2 B3_5xC_2 B4_5xC_2 B5_5xC_2 B6_5xC_2 B7_5xC_2 B8_5xC_2 B9_5xC_2 B10_5xC_2 B11_5xC_2 B12_5xC_2 C1_5xC_2 C2_5xC_2 C3_5xC_2 C4_5xC_2 C5_5xC_2 C6_5xC_2 C7_5xC_2 C8_5xC_2 C9_5xC_2 C10_5xC_2 C11_5xC_2 C12_5xC_2 D1_5xC_2 D2_5xC_2 D3_5xC_2 D4_5xC_2 D5_5xC_2 D6_5xC_2 A1_5xC_3 A2_5xC_3 A3_5xC_3 A4_5xC_3 A5_5xC_3 A6_5xC_3 A10_5xC_3 A11_5xC_3 A12_5xC_3 B1_5xC_3 B2_5xC_3 B3_5xC_3 B4_5xC_3 B5_5xC_3 B6_5xC_3 B7_5xC_3 B8_5xC_3 B9_5xC_3 B10_5xC_3 B11_5xC_3 B12_5xC_3 C1_5xC_3 C2_5xC_3 C3_5xC_3 C4_5xC_3 C5_5xC_3 C6_5xC_3 C7_5xC_3 C8_5xC_3 C9_5xC_3 C10_5xC_3 C11_5xC_3 C12_5xC_3 D1_5xC_3 D2_5xC_3 D3_5xC_3 D4_5xC_3 D5_5xC_3 D6_5xC_3 A1_5xD_1 A2_5xD_1 A3_5xD_1 A4_5xD_1 A5_5xD_1 A6_5xD_1 A10_5xD_1 A11_5xD_1 A12_5xD_1 B1_5xD_1 B2_5xD_1 B3_5xD_1 B4_5xD_1 B5_5xD_1 B6_5xD_1 B7_5xD_1 B8_5xD_1 B9_5xD_1 B10_5xD_1 B11_5xD_1 B12_5xD_1 C1_5xD_1 C2_5xD_1 C3_5xD_1 C4_5xD_1 C5_5xD_1 C6_5xD_1 C7_5xD_1 C8_5xD_1 C9_5xD_1 C10_5xD_1 C11_5xD_1 C12_5xD_1 D1_5xD_1 D2_5xD_1 D3_5xD_1 D4_5xD_1 D5_5xD_1 D6_5xD_1 A1_5xD_2 A2_5xD_2 A3_5xD_2 A4_5xD_2 A5_5xD_2 A6_5xD_2 A10_5xD_2 A11_5xD_2 A12_5xD_2 B1_5xD_2 B2_5xD_2 B3_5xD_2 B4_5xD_2 B5_5xD_2 B6_5xD_2 B7_5xD_2 B8_5xD_2 B9_5xD_2 B10_5xD_2 B11_5xD_2 B12_5xD_2 C1_5xD_2 C2_5xD_2 C3_5xD_2 C4_5xD_2 C5_5xD_2 C6_5xD_2 C7_5xD_2 C8_5xD_2 C9_5xD_2 C10_5xD_2 C11_5xD_2 C12_5xD_2 D1_5xD_2 D2_5xD_2 D3_5xD_2 D4_5xD_2 D5_5xD_2 D6_5xD_2 A1_5xD_3 A2_5xD_3 A3_5xD_3 A4_5xD_3 A5_5xD_3 A6_5xD_3 A10_5xD_3 A11_5xD_3 A12_5xD_3 B1_5xD_3 B2_5xD_3 B3_5xD_3 B4_5xD_3 B5_5xD_3 B6_5xD_3 B7_5xD_3 B8_5xD_3 B9_5xD_3 B10_5xD_3 B11_5xD_3 B12_5xD_3 C1_5xD_3 C2_5xD_3 C3_5xD_3 C4_5xD_3 C5_5xD_3 C6_5xD_3 C7_5xD_3 C8_5xD_3 C9_5xD_3 C10_5xD_3 C11_5xD_3 C12_5xD_3 D1_5xD_3 D2_5xD_3 D3_5xD_3 D4_5xD_3 D5_5xD_3 D6_5xD_3 Factors Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 320 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 323 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 326 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 321 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 324 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 327 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Dermabacter sp. | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus subtilis | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Bacillus megaterium | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 322 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 325 | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 328 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:TSB control | Concentration:5 times concentrated Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 320 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 323 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 326 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 321 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 324 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 327 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 348 | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Dermabacter sp. | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus subtilis | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Bacillus megaterium | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 322 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 325 | Concentration:5 times diluted Bacterial strain:Enterococcus faecium 328 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis Tu | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 1-2 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-1 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-5 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:Staphylococcus epidermidis 2-6 | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted Bacterial strain:TSB control | Concentration:5 times diluted N'-Formylkynurenine C13 34103952 33128532 30515420 31034102 27662402 17330268 29264000 30641256 32695560 24702728 24456324 26427832 26064898 26562600 29531822 29556814 29594926 25053640 28633084 24356522 30331078 31286100 30403274 31144988 28073416 29268314 27557172 30102110 28466782 26977992 25654152 28860538 28980680 30675254 31501120 28033908 25384332 27516344 25529244 32988876 34192820 34020216 31466542 26667114 30831494 31291504 35027420 32303790 27915740 30275114 29782184 33310010 33266392 33810516 33156936 33567760 33488620 32272090 29456402 29933696 33498866 33890272 35100444 31874264 34087140 33782916 33439968 35214340 36627632 32373628 33622044 35372380 35180328 32411116 33999224 33926744 32587676 28511506 32990534 34458752 32893856 30331470 31804974 33044860 31649004 28415444 30768072 29206446 32902852 31268950 30083932 30085980 29288884 29981530 28930644 28841560 25833240 25572434 32082010 32472084 28517252 29745754 32628244 34373964 33264468 32233198 34189088 33087116 31416158 27094470 29005610 27172084 30667480 29803164 28875664 25505572 28458100 44769732 42142728 43057380 41371308 41693580 42729220 41963220 41602596 25045966 41082432 35334672 35710820 40860696 29950112 40165640 41365100 40457856 40371336 31197668 28485644 33031900 38046008 34453776 35851764 34585448 36370888 35609316 35900236 35743548 35759812 34737156 30256504 36941008 37590596 24618644 24059168 22376090 22299876 22275206 36797580 35577268 26375780 35015380 34868496 37548508 26325954 34245496 37837332 37180860 35136080 36796332 36756920 26472102 25911770 32452762 31133494 32481806 26612360 31151658 28751130 29870676 18436092 31790832 29726790 30096840 30606486 29899520 30621042 28555750 30947546 29799388 30253220 31148612 29682018 29321486 22376090 22299876 22275206 31500940 25006478 30653018 24612860 24596014 32315224 34950092 35319444 34486904 30922500 34990976 31118902 34370792 34282308 34173776 23309112 32663040 29311932 28395748 33202822 34023940 26482004 39991992 39364580 37009164 40533636 29042150 30826246 30170046 29445552 35737148 35486916 33216822 26940818 30596308 28582446 25413982 21158994 23443208 Indole-3-acrylic acid 1595796.375 1392394.5 1090332.25 1929352 1977818.75 2236790.25 1171579.625 861124.25 860727.5625 1162630.75 1005980 1695592 1111857.25 1238255.375 1029724.875 1080102.25 763516.75 1136359 1147815.75 1083442 1516201.375 999316.25 1244843.875 1389051.25 1602976.25 836378.625 1457335.75 1233138.25 1122838 1211663 734159.25 1026112.313 1115803.25 1258078.5 1317345.5 1493417.625 995813.1875 1519969.75 1586382.25 1843282.5 1363458.5 1840163.375 1871002.25 1736056.5 1792134.5 1208994.625 1232015.75 1525319.25 1222454.75 1052663.375 1862845.25 1577767.75 1301581 1576298.75 1628232 1291394.625 966050.25 1044435.688 1230857.375 1379649.375 915994.125 1015559.625 858872.875 958954.4375 1701875.75 1340759.5 1556539.125 1170113.125 1259439.5 1309917.75 2000068 1257265 1256337.125 1113819.875 1030699.625 1415999.5 1799914.875 854612.875 606777.8125 1249963.125 999240.125 1707318.125 1763784.25 1506888.25 1667252.75 1029635.625 1150675.5 1025025.313 1627932.375 1388535.125 859359.0625 759245 1113117.5 660776.625 815588.3125 878851.1875 748964.875 807486.375 1022855.313 1219259 777429.625 948070.125 1183798.75 1092501.25 898502.6875 842953.8125 1149617.5 837847.3125 920520.5 535659.75 848390.1875 763404.5 663977.75 707885.375 734114.875 484485.5 912053.0625 Indole-3-ethanol 4227120.5 2381556.5 3259430 4597740 5438485.5 5629498 9214988 10417262 14604236 5490894 5202858 5714486 2582850.75 2180856.25 1999416.375 4197114.5 4241765 4220437 1996905.75 1819336.875 1751463 2273861 2128213.25 2433282.75 2416772.75 2276535.25 2348457.75 1951469.5 2077644 2225291.5 917087 1702861.5 2093473.125 2107563.5 2172131 1645249.5 1693802.875 1434354.875 1436470.875 4580480 4407708.5 4426293.5 6488207 6736729.5 6448365 11266670 15056753 12403884 6864661 7053092 6020882 2404603.25 2145048.75 2392164.5 4610853.5 4513134.5 4504542 1332564.25 1906735 1809100.875 2233435.25 2396211.25 2522087.75 1450583.375 2197222.5 2508779.5 2041280.625 2179429.5 2488295.5 1108659 2377458.75 2446612.75 2257477 2228011.5 2184284.25 1605246.25 1660161.25 1674909.25 2978474 5328390 4680763 6047676.5 6434559 5966364 6087456.5 8002266 10639452 1335774.875 3896289.25 4545278.5 1166802.25 1369113.75 2101935 3910350.25 4014080.5 3715682.75 1673307.125 1524830.25 1501570.625 2344895.75 2305135.75 2059867.5 2116389.25 1760178.875 1817640.75 2017320.125 1784899.875 1898074.5 1848301.375 1475512.125 2029331.875 1698625.875 2019702.5 1504076.125 1398017.25 1382137.875 1645686.625 Indole-3-propionic acid 347992.8125 326500.25 309594.625 1058901.75 503569.9375 504795.75 478429.5938 532505 494769.875 325409.25 325252.375 330594.2813 419330.4375 340636.75 367727.7813 297828.9375 337308.3125 308635.125 401253.375 397214.0625 465592.8438 366744.6563 363431.1875 435147.6875 457621.8438 383468.25 397394.3125 367650.75 398753.9375 408940.8438 187902.4063 445163.5 403900.875 381942.4063 417568.6875 248843.7188 510012.625 482749.5625 479837.375 322434.6563 306010.1563 280030.3438 558316.1875 546300.1875 524668.8125 506138.2188 565941.75 534334.3125 264965.6875 350881.6875 298527.4375 354688.6563 314788.4688 369872.4688 274690.0625 352198.0938 290817.6875 222155.8125 328620.7188 402076.8438 432244.8125 377151.375 394085.1875 214540.0781 394186.4375 485628.4375 387522.9375 356482.5625 486527.375 145684.1719 356579.875 382302.625 413240.1563 358292.125 366248.2813 489509.375 445949.0625 431137.0938 57374.13281 270986.625 244348.125 504573.0625 514381.6563 514664.0625 466985.8125 459038.8125 497720.4375 4738.467285 147784.7813 208841.1875 182218.6875 188173.0469 322511.875 167542.2188 200676.3125 144905.3438 344495.7813 255179.7656 319112.5313 413875.4688 354401.625 303920.7188 317062.9688 260422.1719 285521.0625 305414.7188 267852.9063 270243.2813 248631.4688 201461.3281 293517.4688 234929.2656 289288.7813 205014.8594 317195.9063 345308.375 372244.3125 Indole-3-acetic acid 2770593 2489287 2315667.25 3837620 3798452.5 3862779.25 12892284 12471190 13715998 10167877 8843399 8616733 6517162 6413395 6279760 2575915 2351872.75 2741861.75 6995272 6560467 7410997.5 6856954 8907939 8963064 8916756 7839195.5 8586566 7995778.5 8578983 9184815 6493255.5 9579785 10200684 8639359 8236462.5 6531638 3524494.25 3873483.5 3606002 2814556.5 2942620.75 2775210 4405875.5 4307704 4293304 12546386 13034635 15890921 9796726 8824710 8547338 6464347.5 6554168.5 6614564 3190528 2972641 3199398 6599725 7002847.5 7709389.5 7808480 8401090 7336978.5 6953554 8436155 8807965 8135585 8046917 8953660 6911625 9187046 10114594 8152606 7319373.5 7434664 3652230.25 3514761.25 2689755 2079060 3104704 2967479 3936210.25 3890585.75 3847648.25 12659962 11971984 12773534 14862531 13139073 11341948 6496330 5933368.5 5761686.5 2626096 2319838.25 2336809.25 5750923.5 5378473 6487892.5 8309673.5 7284949 7104895 7028776 6806058 6918969.5 6331524.5 6236834 6437407 6317841 6588830.5 7934048 5899333 4984795 5322368 2613753 2736208.75 2398514.5 Indole-3-carboxaldehyde 155099040 145438672 147361424 111094440 127389776 120474832 12017160 16418774 19246800 172346720 153520288 157638304 112263280 90369920 110812240 129208960 134301824 137368720 98580336 115571648 143870304 160020928 128705152 131906912 127406176 101541120 123295600 115135104 123884352 113565824 37455128 132431584 114539064 120395920 134554544 71104728 132610008 92741904 108550992 130970832 129102592 126288064 125269976 116234488 111319216 14925000 19966044 20277068 150678704 173165760 149001152 100609536 88791760 106994864 124259648 159443200 139306288 57903596 109882088 118619000 131121984 110758176 119450784 60624116 124571776 153517216 126984784 123011120 164841408 40375000 106975072 112045656 127548048 122036096 116329280 91364848 127133888 114963760 45180992 114480000 105673080 99600832 108658944 113206152 16408699 17143124 19503616 84992120 125832696 140158368 37262864 47619096 87786016 78439856 85857144 67276480 91062640 73354912 88714424 114117776 97185600 82160960 95257072 72179760 77836128 87324080 78575096 80578240 67230160 51228960 76035824 63482424 87472608 60866152 78707504 71060256 113288576 Indole-3-lactic acid 448318.1875 395767.8125 455066.25 559587.0625 361759.5313 434918.75 30373184 26805584 33748848 22200332 19088614 10403014 1057436.125 1038456.125 736197.375 745953 429817.1875 716592.875 16665855 12591282 13334657 2155162 2321601.25 2020620.25 2440675.5 2977503.25 2858048.5 2762092.5 3098263.5 3032068.5 4019342.5 3414140 3856569 4415530.5 2145225.75 2551792 56724.33594 259021.7813 132368.4375 572617.5 521889.8125 653345.0625 256486.7969 379922.625 345844.1875 26193370 22613020 27755064 18127862 11705306 11983504 827914 946232.375 904728 621625.9375 462723.5 275682.7813 18733544 9682231 13737642 1371837.5 2347956 2237657.5 2682653.75 1869374.5 1679196.75 1921552.125 1986356.5 1656074.875 3059306.5 2377786.5 2585823.75 2388077.75 1855119.375 2076886.375 291277 158379.3438 48419.42969 759114.8125 506260.5 618120.625 506943.6875 483247.625 295788.75 23197956 22496484 20120668 21947470 14443184 11184934 901349.625 852968.4375 679806.5 590328.1875 384941.5625 677748.625 10384205 8744490 11609336 2266932.5 2062200.25 2042151.375 1471284.375 1927624.125 1954186.5 1632489.125 1675025.5 1626478.625 1495479.25 2143281.75 1909516.75 2195202.25 1624147.125 1862435 180088.5313 219559.25 79929.35938 N'-Formylkynurenine 176954032 164309648 166374704 115681616 116817872 120144480 140095232 140842128 88180056 132164896 111020392 111760904 153879568 115659392 153977344 167810688 159339872 153131552 99984576 89364808 103840056 121630424 109605296 111222808 106799432 116355296 108369920 111003752 111150496 113778880 110060296 94922776 113967544 123065232 82408472 79916808 66781696 68062096 65998968 146410656 135766304 98131432 96779120 96114360 101258016 87623656 117569016 128816024 121851400 112113520 111933448 133487600 93570032 96036488 131920224 123456264 123689168 83677712 97381160 90806392 94506792 60004500 102012728 90484032 101556208 102139632 101204904 102288096 90846544 102825040 97566448 98711424 96442064 91993016 92245104 47448.65234 21688.64453 3380.019775 125795504 100530232 124518216 68772560 67436600 94705064 119218136 121786480 122359264 102325744 112376832 102254416 129100672 133271384 129854704 91299328 125078320 111340992 85112984 108106112 111105128 88157176 129513392 129268336 123222464 130933960 96602696 100601632 98204464 95130552 115441288 120425080 109498128 88340040 94806248 88312984 69702328 59579868 65242076 Kynurenine 120731888 115277168 118330784 115701312 117368592 117176888 119446048 120556656 71354472 106861424 100707544 98569176 107692120 99091160 111179488 112416984 104502112 100980592 83279064 58679632 86698264 98235872 95804416 96962456 92233616 96216904 95236504 96082280 97588024 93092464 94600240 63364776 94889904 97751912 60887476 59795552 58505932 57840384 55649728 101851984 96576400 64424576 94568480 88261072 96577976 66943964 97457592 104365616 101514776 94460560 91069056 86331896 61466112 64460712 78035488 72638800 74307792 62047032 66111188 64209776 69620632 51274916 70958544 69705896 70044400 72634800 69188624 73615136 66533400 72175888 69009912 72153208 68872912 65885156 65343856 7234.931641 8747.382813 4043.330811 76242032 72309608 73975144 66064592 66614980 79318120 102534176 101268952 102007608 75180728 91837360 73087136 82731800 85917112 80138704 68543488 76315632 68162384 65373120 77914736 77811800 65799920 97048600 95838552 96683304 99652296 68918224 64408036 69721928 69580128 91638696 92501592 88163360 66941744 79314696 74834120 67615688 55037724 63538080 Tryptamine 1519805.375 1644048.875 1376385.75 165327728 161448816 185734160 388012.2188 437672.875 367616.0625 261311.6406 494309.4375 330790.8438 10899264 6339486 10112558 1385898.25 1497376.75 1556394.875 356531.0938 395321.5313 320448.9375 399375.5625 297488.1563 271915.375 378801.25 263030.0938 269771.0313 277059.875 272000.5313 269390.9688 265931.2813 475442.5625 228359.5469 476442.5938 435048.25 467176.9063 396678.9688 426054 320879.9375 1215054.125 1445316.75 1219988.25 146955840 153263792 150723696 399652.5 389632.2188 496960 512857.1563 438767.9688 251061.6875 11083796 8203228 8368631.5 1537203.875 1545940.625 1760204.125 397280.9375 445385.9063 456414.875 418503.7813 231145.2344 449336.4375 429450.6875 476712.9688 446443.7813 451674.2813 480686.625 414659.75 480913.6875 443609.375 464960.625 452637.2188 409939.25 400177.375 6564.584961 5097.116699 2609.39502 1163025.625 1283370.375 1187112.375 101346864 113748992 155651696 420790.7188 341666.5938 472493.9375 451171.375 425002.9063 407568.1875 11364409 12073448 11733795 974941.4375 1561518.25 1468519.375 425163.8125 511827.0313 506556.2188 371043.8125 508056.4688 498053.2813 449323 461742.8438 465719.9688 521618.5625 471680.7188 470900.25 430601.875 439807.6875 414877.4063 477991.6563 415847.2188 351818.0625 353394.0625 312427.9375 325675.0313 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name PubChemID KeggID N'-Formylkynurenine C13 Indole-3-acrylic acid 5375048 Indole-3-ethanol 10685 C00955  Indole-3-propionic acid 3744 Indole-3-acetic acid 802 C00954  Indole-3-carboxaldehyde 10256   C08493  Indole-3-lactic acid 92904 N'-Formylkynurenine 910 C02700  Kynurenine 846 C00328  Tryptamine 1150 C00398 METABOLITES_END #END