#METABOLOMICS WORKBENCH purdylab_20221230_115930 DATATRACK_ID:3678 STUDY_ID:ST002421 ANALYSIS_ID:AN003942 PROJECT_ID:PR001559
VERSION             	1
CREATED_ON             	January 3, 2023, 10:19 am
#PROJECT
PR:PROJECT_TITLE                 	UBXD8 lipidomics from whole cells
PR:PROJECT_SUMMARY               	The intimate association between the endoplasmic reticulum (ER) and
PR:PROJECT_SUMMARY               	mitochondrial membranes at ER-mitochondria contact sites (ERMCS) serves as a
PR:PROJECT_SUMMARY               	platform for several critical cellular processes, in particular lipid synthesis.
PR:PROJECT_SUMMARY               	Enzymes involved in lipid biosynthesis are enriched at contacts and membrane
PR:PROJECT_SUMMARY               	lipid composition at contacts is distinct relative to surrounding membranes. How
PR:PROJECT_SUMMARY               	contacts are remodeled and the subsequent biological consequences of altered
PR:PROJECT_SUMMARY               	contacts such as perturbed lipid metabolism remains poorly understood. Here we
PR:PROJECT_SUMMARY               	investigate if the ER-tethered ubiquitin-X domain adaptor 8 (UBXD8) regulates
PR:PROJECT_SUMMARY               	the lipidome of cells. LC-MS/MS lipidomics found significant changes in distinct
PR:PROJECT_SUMMARY               	lipid species in UBXD8 knockout cells, in particular in saturated or
PR:PROJECT_SUMMARY               	mono-unsaturated lipid species. Perturbation of contacts and inherent lipid
PR:PROJECT_SUMMARY               	synthesis is emerging as a hallmark in a variety of human disorders such as
PR:PROJECT_SUMMARY               	neurodegeneration. Our results suggest that contacts are exquisitely sensitive
PR:PROJECT_SUMMARY               	to alterations to membrane lipid composition and saturation in a manner that is
PR:PROJECT_SUMMARY               	dependent on UBXD8.
PR:INSTITUTE                     	University of Arizona
PR:DEPARTMENT                    	Immunobiology
PR:LABORATORY                    	Purdy Lab
PR:LAST_NAME                     	Purdy
PR:FIRST_NAME                    	John
PR:ADDRESS                       	PO Box 245221, Tucson, Arizona, 85724, USA
PR:EMAIL                         	purdylab@gmail.com
PR:PHONE                         	520-626-4371
PR:FUNDING_SOURCE                	NIH R01 AI162671
PR:CONTRIBUTORS                  	Rakesh Ganji, Joao A. Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S.
PR:CONTRIBUTORS                  	Clemen, Conrad C. Weihl, John G. Purdy, Steve P. Gygi, and Malavika Raman
#STUDY
ST:STUDY_TITLE                   	UBXD8 lipidomics from whole cells (Part 1)
ST:STUDY_SUMMARY                 	The intimate association between the endoplasmic reticulum (ER) and
ST:STUDY_SUMMARY                 	mitochondrial membranes at ER-mitochondria contact sites (ERMCS) serves as a
ST:STUDY_SUMMARY                 	platform for several critical cellular processes, in particular lipid synthesis.
ST:STUDY_SUMMARY                 	Enzymes involved in lipid biosynthesis are enriched at contacts and membrane
ST:STUDY_SUMMARY                 	lipid composition at contacts is distinct relative to surrounding membranes. How
ST:STUDY_SUMMARY                 	contacts are remodeled and the subsequent biological consequences of altered
ST:STUDY_SUMMARY                 	contacts such as perturbed lipid metabolism remains poorly understood. Here we
ST:STUDY_SUMMARY                 	investigate if the ER-tethered ubiquitin-X domain adaptor 8 (UBXD8) regulates
ST:STUDY_SUMMARY                 	the lipidome of cells. LC-MS/MS lipidomics found significant changes in distinct
ST:STUDY_SUMMARY                 	lipid species in UBXD8 knockout cells, in particular in saturated or
ST:STUDY_SUMMARY                 	mono-unsaturated lipid species. Perturbation of contacts and inherent lipid
ST:STUDY_SUMMARY                 	synthesis is emerging as a hallmark in a variety of human disorders such as
ST:STUDY_SUMMARY                 	neurodegeneration. Our results suggest that contacts are exquisitely sensitive
ST:STUDY_SUMMARY                 	to alterations to membrane lipid composition and saturation in a manner that is
ST:STUDY_SUMMARY                 	dependent on UBXD8.
ST:INSTITUTE                     	University of Arizona
ST:DEPARTMENT                    	Immunobiology
ST:LABORATORY                    	Purdy Lab
ST:LAST_NAME                     	Purdy
ST:FIRST_NAME                    	John
ST:ADDRESS                       	PO Box 245221, Tucson, Arizona, 85724, USA
ST:EMAIL                         	purdylab@gmail.com
ST:PHONE                         	520-626-4371
#SUBJECT
SU:SUBJECT_TYPE                  	Cultured cells
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:CELL_STRAIN_DETAILS           	HEK293T
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	20190829_neg_KO_1	Description:UBXD8 Knockout	RAW_FILE_NAME=20190829_neg_KO_1.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20190829_neg_KO_2	Description:UBXD8 Knockout	RAW_FILE_NAME=20190829_neg_KO_2.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20190829_neg_wt_1	Description:Wild-type	RAW_FILE_NAME=20190829_neg_wt_1.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20190829_neg_wt_2	Description:Wild-type	RAW_FILE_NAME=20190829_neg_wt_2.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20190829_pos_KO_1	Description:UBXD8 Knockout	RAW_FILE_NAME=20190829_pos_KO_1.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20190829_pos_KO_2	Description:UBXD8 Knockout	RAW_FILE_NAME=20190829_pos_KO_2.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20190829_pos_wt_1	Description:Wild-type	RAW_FILE_NAME=20190829_pos_wt_1.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20190829_pos_wt_2	Description:Wild-type	RAW_FILE_NAME=20190829_pos_wt_2.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep2_KO_a	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_neg_rep2_KO_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep2_KO_b	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_neg_rep2_KO_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep2_WT_a	Description:Wild-type	RAW_FILE_NAME=20191130_neg_rep2_WT_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep2_WT_b	Description:Wild-type	RAW_FILE_NAME=20191130_neg_rep2_WT_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep3_KO_a	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_neg_rep3_KO_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep3_KO_b	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_neg_rep3_KO_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep3_WT_a	Description:Wild-type	RAW_FILE_NAME=20191130_neg_rep3_WT_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_neg_rep3_WT_b	Description:Wild-type	RAW_FILE_NAME=20191130_neg_rep3_WT_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep2_KO_a	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_pos_rep2_KO_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep2_KO_b	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_pos_rep2_KO_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep2_WT_a	Description:Wild-type	RAW_FILE_NAME=20191130_pos_rep2_WT_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep2_WT_b	Description:Wild-type	RAW_FILE_NAME=20191130_pos_rep2_WT_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep3_KO_a	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_pos_rep3_KO_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep3_KO_b	Description:UBXD8 Knockout	RAW_FILE_NAME=20191130_pos_rep3_KO_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep3_WT_a	Description:Wild-type	RAW_FILE_NAME=20191130_pos_rep3_WT_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191130_pos_rep3_WT_b	Description:Wild-type	RAW_FILE_NAME=20191130_pos_rep3_WT_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_neg_rep2_KO_a	Description:UBXD8 Knockout	RAW_FILE_NAME=20191230_neg_rep2_KO_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_neg_rep2_KO_b	Description:UBXD8 Knockout	RAW_FILE_NAME=20191230_neg_rep2_KO_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_neg_rep2_WT_a	Description:Wild-type	RAW_FILE_NAME=20191230_neg_rep2_WT_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_neg_rep2_WT_b	Description:Wild-type	RAW_FILE_NAME=20191230_neg_rep2_WT_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_pos_rep2_KO_a	Description:UBXD8 Knockout	RAW_FILE_NAME=20191230_pos_rep2_KO_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_pos_rep2_KO_b	Description:UBXD8 Knockout	RAW_FILE_NAME=20191230_pos_rep2_KO_b.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_pos_rep2_WT_a	Description:Wild-type	RAW_FILE_NAME=20191230_pos_rep2_WT_a.mzXML
SUBJECT_SAMPLE_FACTORS           	-	20191230_pos_rep2_WT_b	Description:Wild-type	RAW_FILE_NAME=20191230_pos_rep2_WT_b.mzXML
#COLLECTION
CO:COLLECTION_SUMMARY            	Cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM),
CO:COLLECTION_SUMMARY            	supplemented with 10% fetal bovine serum (FBS) and 100 units/mL penicillin and
CO:COLLECTION_SUMMARY            	streptomycin. Cells were maintained in a humidified, 5 % CO2 atmosphere at
CO:COLLECTION_SUMMARY            	37°C. The CRISPR-Cas9 gene editing system was used to generate UBXD8 knockout
CO:COLLECTION_SUMMARY            	cell lines in HEK293T cells. Cells were grown in 6-well plates for lipidomics.
CO:COLLECTION_SUMMARY            	Cells were washed with PBS, scraped into cold 50% methanol, centrifuged, and the
CO:COLLECTION_SUMMARY            	cell pellets were frozen at -80˚C. Next, cells were resuspended in cold 50%
CO:COLLECTION_SUMMARY            	methanol (1mL) and transferred to glass vials. Chloroform was added (0.5mL) and
CO:COLLECTION_SUMMARY            	the mixture was gently vortexed and centrifuged at 1,000x g for 5 min at 4˚C.
CO:COLLECTION_SUMMARY            	Lipids were transferred to a clean glass vial using a glass Hamilton syringe.
CO:COLLECTION_SUMMARY            	Lipids were extracted twice using chloroform prior to being dried under nitrogen
CO:COLLECTION_SUMMARY            	gas. Samples were normalized according to protein concentration when resuspended
CO:COLLECTION_SUMMARY            	in a 1:1:1 solution of methanol:chloroform:isopropanol prior to mass
CO:COLLECTION_SUMMARY            	spectrometry (MS) analysis.
CO:SAMPLE_TYPE                   	Epithelial cells
#TREATMENT
TR:TREATMENT_SUMMARY             	Wild-type vs UBXD8 Knockout
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Lipids were isolated from collected cultured cells. Cells were washed with PBS,
SP:SAMPLEPREP_SUMMARY            	treated with cold 50% methanol (1mL) and transferred to glass vials. Next,
SP:SAMPLEPREP_SUMMARY            	chloroform (0.5mL) was added and samples were gently vortexed and centrifuged at
SP:SAMPLEPREP_SUMMARY            	1,000x g for 5 min at 4˚C. Lipids were transferred to a clean glass vial using
SP:SAMPLEPREP_SUMMARY            	a glass Hamilton syringe. Lipids were extracted twice using chloroform prior to
SP:SAMPLEPREP_SUMMARY            	being dried under nitrogen gas. Samples were normalized according to protein
SP:SAMPLEPREP_SUMMARY            	concentration when resuspended in a 1:1:1 solution of
SP:SAMPLEPREP_SUMMARY            	methanol:chloroform:isopropanol prior to mass spectrometry (MS) analysis.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Vanquish
CH:COLUMN_NAME                   	Phenomenex Kinetex C18 (150 x 2.1mm,2.6um)
CH:SOLVENT_A                     	40% water; 60% methanol 10mM ammonium formate and 0.1% formic acid
CH:SOLVENT_B                     	10% methanol; 90% isopropanol 10mM ammonium formate and 0.1% formic acid
CH:FLOW_GRADIENT                 	25% to 100%
CH:FLOW_RATE                     	0.25mL per min
CH:COLUMN_TEMPERATURE            	60
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Plus Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	Samples were run in a semi-random order where WT or UBXD8 KO samples were
MS:MS_COMMENTS                   	interspersed with blank samples. Lipids were ionized using a heated electrospray
MS:MS_COMMENTS                   	ionization (HESI) source and nitrogen gas and measured using a Q-Exactive Plus
MS:MS_COMMENTS                   	mass spectrometer operating at a MS1 resolution of either 70,000 or 140,000 and
MS:MS_COMMENTS                   	a MS2 resolution of 35,000. MS1 Spectra were collected over a mass range of 200
MS:MS_COMMENTS                   	to 1,600 m/z with an automatic gain control (AGC) setting of 1e6 and transient
MS:MS_COMMENTS                   	times of 250 ms (70,000 resolution) or 520 ms (140,000 resolution). MS2 spectra
MS:MS_COMMENTS                   	were collected using a transient time of 120 ms and an AGC setting of 1e5. Each
MS:MS_COMMENTS                   	sample was analyzed using negative and positive ion modes. The mass analyzer was
MS:MS_COMMENTS                   	calibrated weekly. SPLASH LIPIDOMIX mass spectrometry standards (Avanti Polar
MS:MS_COMMENTS                   	Lipids) were used in determining extraction efficiencies and lipid quantitation.
MS:MS_COMMENTS                   	Lipids were identified and quantified using MAVEN, and EI-MAVEN (Elucidata).
MS:MS_COMMENTS                   	UHPLC retention time, MS1 peaks, and MS2 fragments were used to identify lipids.
MS:MS_COMMENTS                   	Lipids were included if they were observed in 3-6 samples in both UBXD8 KO and
MS:MS_COMMENTS                   	WT cells. Missing values in a sample were not imputed. The following lipid
MS:MS_COMMENTS                   	classes were included in the analysis: cholesteryl esters (CE), diacylglycerol
MS:MS_COMMENTS                   	(DG), phosphatidylcholine (PC), phosphatidylethanolamine (PE),
MS:MS_COMMENTS                   	phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylserine (PS),
MS:MS_COMMENTS                   	and triacylglycerol (TG). Guidelines from the Lipidomic Standards Initiative
MS:MS_COMMENTS                   	were followed for lipid species identification and quantification, including
MS:MS_COMMENTS                   	consideration of isotopic patterns resulting from naturally occurring 13C atoms
MS:MS_COMMENTS                   	and isomeric overlap. The following MS2 information was used to confirm each
MS:MS_COMMENTS                   	lipid species: PC fragment of 184.073 (positive mode) and tail identification
MS:MS_COMMENTS                   	using formic adduct (negative mode); PE fragment of 196.038 or the tail plus
MS:MS_COMMENTS                   	197.046 (negative mode) and neutral loss (NL) of 141.019 (positive mode); PG
MS:MS_COMMENTS                   	fragment of 152.996 plus the identification of the FA tails (negative mode) and
MS:MS_COMMENTS                   	NL 189.04 of [M+NH4]+ adduct (positive mode); PI fragment of 241.012 (negative)
MS:MS_COMMENTS                   	and NL 277.056 of [M+NH4]+ adduct (positive mode); PS NL of 87.032 (negative);
MS:MS_COMMENTS                   	DG and TG by NL of FA tails (positive mode); and CE fragment of 369.352 or
MS:MS_COMMENTS                   	neutral loss of 368.35 (positive).
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	peak area
MS_METABOLITE_DATA_START
Samples	20190829_pos_wt_1	20190829_pos_wt_2	20190829_pos_KO_1	20190829_pos_KO_2	20191130_pos_rep2_WT_a	20191130_pos_rep2_WT_b	20191130_pos_rep2_KO_a	20191130_pos_rep2_KO_b	20191130_pos_rep3_WT_a	20191130_pos_rep3_WT_b	20191130_pos_rep3_KO_a	20191130_pos_rep3_KO_b	20191230_pos_rep2_WT_a	20191230_pos_rep2_WT_b	20191230_pos_rep2_KO_a	20191230_pos_rep2_KO_b
Factors	Description:Wild-type	Description:Wild-type	Description:UBXD8 Knockout	Description:UBXD8 Knockout	Description:Wild-type	Description:Wild-type	Description:UBXD8 Knockout	Description:UBXD8 Knockout	Description:Wild-type	Description:Wild-type	Description:UBXD8 Knockout	Description:UBXD8 Knockout	Description:Wild-type	Description:Wild-type	Description:UBXD8 Knockout	Description:UBXD8 Knockout
LPC(16:0)	12817490	21042220	23114680	60232310	896862.19	1498761	1885417.88	1126845.62	635201.5	946461.81	1518444	1741995.38	848463.31	1591263.38	3231538	3255778
LPC(16:1)					118985.66	287302.03	250101	168730.8	28447.76	36633.21	55588.34	77139.62	87555.46	183059.42	329257.28	380004.84
LPC(18:0)					236997.58	233419.75	474942.75	450276	211665.55	130114.41	239820.55	291987.09	165012.67	275812.72	665439.75	746326.25
LPC(18:1)	44950660	55977030	58418160	124804100	1728072.5	3371162	3221535.25	2198726.25	469003.09	585282.44	915444.81	1251556.12	1319158.5	1895717.5	4655653.5	5309140.5
LPC(20:1)	1858519	2587534	4686544	11847360	193395.2	485651.41	561049.69	273244.22	66750.66	102140.55	205427	271357.34	134699.36	205531.8	658163.44	803552
LPC(20:3)					41681.45	88376.2	134406.14	76795.54	12695.06	27495.98	38240.38	56762.72	53731.31	102782.9	316336.84	419419.16
LPC(20:4)					30304.4	66045.35	133127.72	67349.68	27919.59	40837.52	39066.59	53232.91	78346.06	148150.38	427663.28	509254.5
LPC(22:4)					43081.71	105181.22	193668.8	96364.09	35950.71	38201.54	70669.64	55689.28	88365.38	175865.05	759946.31	958495.56
LPC(22:5)					15660.58	46969.09	93384.94	52715.96	13044.62	24400.23	21049.19	36762.07	37166.36	85370.57	315463.22	321223.28
PC(28:0)	3703394	6116016	3741376	4837956	420790.41	495272.38	1147984.88	1176714.88	209858.81	195842.5	275774.97	335154.28	436690.78	593434.94	781298.5	1066240.12
PC(30:0)					15957468	19201410	37547068	38861996	7441903.5	7309737.5	10325760	12871949	7475853.5	10885136	19284336	29158078
PC(30:1)					614985.81	1042649.44	1135654.5	1106839	185839.12	181425.25	167117.25	222290.31	490054.91	868298.06	797231	1057051.88
PC(32:0)					94533160	103877544	92357208	92267752	29637432	30239990	34053420	42143888	20554076	28404110	59853292	87192720
PC(32:1)					42622948	95678472	79168384	84567464	4893128.5	5411833.5	5526769.5	7080448	12464393	23257306	32149734	52461600
PC(32:2)	8181619	14114530	3984606	7829624	884433.56	1708607.5	1062638.88	1111236.62	190959.86	197951.62	130582.15	191141.88	433360.41	843288	663517	960856.06
PC(34:0)	111455900	217274000	203998400	314458800	19270782	21082214	15182684	15410865	4982834.5	5421825.5	6414330.5	7602209.5	3849515	4808012.5	9742071	15543884
PC(34:1)	2272505000	4340337000	3707897000	4600991000	291763552	509904672	448987520	476644192	29640918	37030140	45557840	64284608	54373140	89903848	163312512	271339936
PC(34:2)	183647500	320292100	232551000	280690300	15140064	29585472	27948600	29946134	1811742.38	2415647	1998325.62	2879485	4914909.5	8785652	10702102	18766126
PC(34:3)	6342536	9462690	6008263	5809255	242610.02	528576.94	590506.62	814934.19	80328.56	91109.24	68614.34	93365.73	136167.45	274215.53	325735.72	516424.75
PC(36:1)	413979100	740580000	911568400	1121753000	54296064	75629976	72701688	74769320	5520590.5	8326467.5	10553930	15034823	7211774.5	9851164	22139848	38134480
PC(36:2)	687542000	1206199000	1118709000	1393581000	82910344	132113880	116486808	126063768	5216032.5	7316472	7024682	10665470	12403756	22001976	39173184	74883264
PC(36:3)	34969410	69112620	57326860	73351780	5766890.5	12185796	13678272	14225839	859056.25	925092	978837.5	1463106.88	1490627.12	2630746	5534737.5	8110444.5
PC(36:4)							7112722.5	7826316	633054.31	714101.94		872537	1451973.12	2634963	4829935.5	8182193.5
PC(36:5)	4146965		4282801				296641.78		57270.31				121364.9	217891.52	345239.34	505865.84
PC(38:0)					182618.14	137890.23	107417.07	161358.48	36826.62	46002.25	87033.16	89870.46				
PC(38:1)	22378460	35554350	56956930	68003450	2384206	3173022.25	2494914.75	2602023.25	344676.66	440554.03	649494.25	829487.44	283413.16	403055.25	830978.25	1601394.38
PC(38:2)	86763870	143459500	174701500	207110700	10957115	16583109	10853675	13383288	669028.56	1000364.69	1030026.69	1489995	1195476	1951918.5	3137757	5924134.5
PC(38:3)	20922460	36769930	39576730	49972190	3412658.75	5566003	6624128.5	7568442.5	432390.34	515774.38	549821.31	774538.75	573296	958503.31	2233401	4091294
PC(38:4)	11541960	18094100	24423150	24843140	3585283.25	5896951.5	8833779	10145177	755895.69	867330.44	737034.19	1148399.25	983066.06	1703852.88	3324864.75	7802458.5
PC(38:5)						3934206	6423176	6765715.5	525492.31	564378	484897.03	741909	986150.69	1826490	4145126	5677222.5
PC(38:6)					750693.81	1486834.88	3438381.25	3429797.75	278201.66	263334.03	271995.22	381259	542654.19	1080648.12	2050956.38	3811329.25
PC(40:0)	3191496	4812220	9289402	16660680	192648.75	212653.58	177059.58	156878.08	30851.55	41137.85	81308.01	70291.08	27340.79	49411.63	102852.73	141799.22
PC(40:1)	9888901	14885250	21973870	31385980	721732.69	777949.44	518188.22	603633.44	110017.18	122188.77	179197.25	235874.12	79200.55	109819.54	274173.12	470694.16
PC(40:2)	12859440	18843960	28624520	33241640	1066247	1316984.12	1338112.12	1505843.12	103111.32	127292.1	194508.14	265468.91	136709.44	206428.8	433633.5	943111
PC(40:3)	3502222	5355127	6989258	8082937	485149	688755.25	639598.06	666172.19	66742.66	80231.23	79483.06	97359.12	68158.65	112365.88	231636.8	402311.75
PC(40:4)	4427020	7907226	11549810	12778950	1052560.38	1615405.62	1949059.38	2156759.75	179120.55	256446.61	180921.31	280872.88	234241.92	360120.09	948366.06	1753457.88
PC(40:5)	5715300	10198840	18279920	15152220	1441675.5	2632012	3390765.25	4166131	265270.22	235477.8	321903.97	483558.84	408899.75	633147.5	1678732	3244935
PC(40:6)					1025438.31	1485461.38	3373505.25	3620649.75	251022.75	300890.28	280841.16	478870.38	383400.25	627732	1573482.12	2921708.75
PC(40:7)	2785694	3827883	4882220	7107672	255996.88	753838.06	1505530.62	1775647.88	159162.64	167390.75	129764.88	210305	365143.03	724643	1363250.5	1990816
PC(42:0)	1301773	2691189	7224656	10074520	127474.76	142339.64	115206.62	107534.59	13469.67	20974.83	50913.68	61611.45	15293.54	30811.84	64758.79	98373.72
PC(42:1)	8874568	13033710	24479110	39316430	562601.56	605918.25	544649.81	545430.69	76354.59	83623.1	209350.81	200227.3	60136.52	88249.34	250311.12	434203.41
PC(42:2)	7336692	10500410	17677230	24059230	573549.94	655129.81	551155.44	594622.5	47253.62	82487.63	121433.93	168768.31	50153.92	84763.7	246629	425159
PC(44:1)	3400856	5632971	15106080	22024400	259193.38	286983.41	274749	308397.97	24784.48	42683.95	134468.56	128728.38	36094.62	48083.04	127583.84	235860.67
PC(44:2)	3021703	4102493	8207761	10698480	236979.3	251808.3	237211.36	270079.47	13495.2	19097.86	87810.25	110314.74	46668.59	40656.77	119355.97	230198.94
PC(46:1)	2129062	2809222	7751280	12116550	167485.44	169824.23	175639.38	158270.36	18646.04	27007.86	77901.99	80979.92	13217.21	24249.16	82898.9	130914.26
PC(46:2)	1500499	2366356	6896772	9962470	128262.19	165272.08	204653.75	227411.39	16836.62	24122.46	52937.57	83874.57	11760.87	23003.02	104848.72	171938.62
PC(48:1)	519599.5	344508.6	3634748	5107424	172602.33	176010.05	124849.55	125478.97	22208.74	13853.32	71757.93	70734.58				
PC(48:2)	2327411	3168625	6326167	10036210	230161.19	233764.2	227731.58	220649.7	18069.51	11012.91	106548.18	121898.19	19620.39	31910.39	107947.99	179022.83
PC(50:2)	3848764	6646691	12404910	17712640	272224.59	297925.59	276953.91	298816.22	20425.88	41349.5	133203.44	131559.47	32539.51	41266.54	144422.09	238711.27
PC(50:3)	416605.3	66506.61	1966692	2047577	50750.88	63971.78	57468.06	66403.78	3906.48	16065.79	22963.98	28112.64				
PC(52:2)					154480.08	180401.45	132650.72	182007.67	8217.19	13893.63	56762.12	73810.41				
PC(52:6)	866949.6	684162.3	1331396	2587796	91397.9	92594.4	90778.26	103055.41	15989.58	34202.71	42203.5	59343.35	19780.73	25504.34	87110.48	113313.38
PC(52:7)					55248.14	75409.32	82718	90302.71	12733.3	22038.42	37413.21	46821.77	13131.51	21887.25	66384.52	89262.1
PC(54:6)					69703.23	75059.34	52668.36	40828.48	18025.78	10649.22	28538.65	11707.58	10531.15	11418.16	40125.28	41079.79
CE(14:0)	2209315	2317113	1790704	2756680									187043.95	298154.28	155376.31	344326.38
CE(16:0)	2202039	2806286	1327222	2217546	559828.56	752136.19	624791.81	620319.44	488564.75	576353.62	487563.5	450612.97	2202039.25	2806285.75	1327222	2217545.75
CE(16:1)	2579368	3003311	1581363	2444514	791021.56	947134.5	725934	815537.94	632416.44	807917	733399.44	778788.25	2579368.25	3003311	1581362.62	2444514.5
CE(18:0)	997586.9	1454004	737996	1177653									997586.94	1454003.62	737996	1177653.12
CE(18:1)	23549480	28676580	10292300	18224530	5845830.5	6822920	4460913.5	5275058	3948439	4119859	4451862.5	4400211.5	23549482	28676584	10292304	18224526
CE(18:2)	3408408	3972197	2439165	3753830	2109563.25	2455610	1703677.62	1926074	2097175	2689950	1974785.62	2203793	3408408.25	3972196.75	2439165.25	3753830
CE(18:3)	254738.4	236888.3	195266	261547.1	240979.73	259386.7	164115.64	187613.56	191994.61	229191.95	201244.06	235871.42	254738.36	236888.33	195265.95	261547.12
CE(20:1)	2792861	2964162	1331660	2414658	362172.41	358837.88	423431.72	400739.16	293053.34	311124.19	394200.78	377154.34	2792861	2964162	1331659.88	2414657.75
CE(20:2)	581656.3	635965.6	219771.8	411890.2	114307.05	149741.48	136676.64	129326.71	141660.05	175754.64	145343.34	143601.33	581656.31	635965.56	219771.75	411890.22
CE(20:3)	517045.5	558416.3	422231.6	553595.8	346927.22	397507.28	285086.78	404921.72	409565.88	418447.28	371332.38	424059.47	517045.5	558416.31	422231.59	553595.88
CE(20:4)	3426596	2930539	2678816	3052721	2679678.25	3234683.25	2222121.75	2552819.25	2616043.5	2783620	2310961.75	2588163	3426595.75	2930539.25	2678815.75	3052721
CE(20:5)	184074	170724.1	143433.2	221296.8	190790.86	210171.12	169701.83	179407.17	195957.75	188800.52	153258.77	141768.17	184074.02	170724.06	143433.23	221296.77
CE(22:0)	256380.6	330938.1	246406.1	321873.6									126961.4	181159.25	113979.81	209631.5
CE(22:1)	865283.4	1124461	641024.8	1036378	142077.05	161543.45	174776.38	230193.62	137756.02	140787.2	180569.83	182520.05	865283.44	1124461.12	641024.81	1036377.56
CE(22:3)					18167.87	27718.24	42444.78	15738.31	64105.81	53476.33	37157.45	32148.34	85166.12	78688.54	59185.33	103282.41
CE(22:4)					45608.28	77733.56	84096.56	96516.84	146819.94	183012.88	45604.39	72214.71	180495.77	201460.86	104195.96	146317.42
CE(22:6)	1134668	933156.2	854628.1	1363250	564335.12	670729.94	610349.81	673504.5	773084	858436.31	636782.75	648105.94	1134668.12	933156.25	854628.19	1363249.5
CE(24:0)	424684.5	490161.1	449031.3	720570									424684.5	490161.09	449031.28	720570
CE(24:1)	1937608	2259092	1474424	2442284	263483.5	251240.83	394592.72	411715.53	201367.98	187884.55	402429.88	372590.03	1937608	2259092.25	1474424	2442283.75
CE(26:0)	397712.8	441881.6	495555.2	777277.4	41907.9	49833.49	107913.48	128185.26	26472.71	17376.99	83288.6	88320	397712.78	441881.59	495555.22	777277.44
CE(26:1)	1047810	1153751	928869.2	1626741	141363.27	128216.4	276696.62	334298.84	118666.46	104964.19	264154.09	262294.62	1047810	1153750.62	928869.06	1626740.62
CE(28:0)	130278.5	166622	176976.5	281764.4									130278.49	166622.02	176976.55	281764.38
CE(28:1)	574371.6	694135.1	594710.3	962553.8	70330.8	79802.16	168942.2	194985.52	30734.31	51078.37	143686.83	151701.25	574371.56	694135	594710.31	962553.75
CE(30:0)	92205.04	105557.4	89362.91	154244.6									92205.04	105557.43	89362.91	154244.62
CE(30:1)	965653.7	1162356	888319.5	1669988	112811.04	128835.01	276564.28	285007.41	56663.91	77122.13	261846.48	221877.31	965653.69	1162356.5	888319.5	1669988.12
CE(30:2)	51598.47	70894.98	67850.77	100088	3676.86	0	25314.66	24874.77	0	2612.75	23406.65	11010.63	51598.47	70894.98	67850.77	100087.99
CE(32:1)	1835130	2257339	1546558	2452921	272534.66	267722.09	375239.72	497488.34	103734.41	96117.87	303713.44	323826.34	1835129.38	2257339.25	1546557.62	2452920.75
CE(32:2)	184865	182028.7	148407.1	252120.8	31694.71	19376.12	58996.96	53269.23	19181.42	4506.85	58118.91	36793.94	184864.95	182028.67	148407.08	252120.83
CE(34:1)	927617.2	1136863	512762.4	773142.8	150871.75	125122.13	133309.38	159918.3	49117.53	56057.76	104238.51	101012.03	927617.19	1136863.38	512762.41	773142.81
CE(34:2)	191409.5	206942.9	100543.8	162882.1									191409.5	206942.88	100543.84	162882.14
CE(34:4)	72376.93	96616.2	44496.57	71508.06									72376.93	96616.2	44496.57	71508.06
CE(34:5)	182817	215267.3	146802.8	229061.5									182817.02	215267.33	146802.78	229061.5
CE(34:6)	183110.2	191207.9	140443.2	210879.2									183110.2	191207.92	140443.22	210879.2
CE(36:1)	142165.6	154780.1	58925.64	88669.53									142165.62	154780.08	58925.64	88669.53
CE(36:2)	82741.62	92594.62	30011.04	31545.56									82741.62	92594.62	30011.04	31545.56
CE(36:6)	253424.9	296679.6	83691.16	129143.8									253424.92	296679.62	83691.16	129143.75
DG(30:0)	1418516	3057811	1779154	2694845	1088652	1277540	1898137	1945360					1257884	1628480	1889782	3220298
DG(32:0)	7831592	14047660	9550883	14983010	7421246	7243442	4622723	4664206					6295696	7665014	7823938	11324900
DG(32:1)	2137656	3806468	3160694	3789764	2252192	2958905	2128481	2333662					797153.6	992374.2	1445184	2239713
DG(34:0)	6342098	11234130	9734945	12885410	3932152	3775841	3291975	2180906					16352470	7074726	12515980	8690856
DG(34:1)	17025650	24445430	19843780	23686690	9945273	1.29E+07	8427914	8076082					3741535	4973126	7206600	12218570
DG(34:2)	1953020	2639302	2473462	2801402	1149152	1564660	843320.5	976573.6					2199258	1828412	2053608	2214050
DG(36:0)					3309634	1523196	4906032	1252124					53284860	19797060	33329530	20020470
DG(36:1)	18156960	19941100	17346830	20935110	4166531	4268472	2120701	2290674					1267998	1674552	2918663	4257888
DG(36:2)	6461258	10319400	7995918	10610000	3675629	4369036	2347183	2740983					1434818	2000182	2894359	5097493
DG(36:3)	538126.2	651805.4	630972.2	860351.3									210153.8	264698	556760.1	796905.5
DG(36:4)	920535.8	1339512	1053495	1071160									487681.6	687248.5	991714.8	1543628
DG(38:1)	1143682	1256974	1387518	1862715	270344.6	273623.7	189988.3	171565.1								
DG(38:2)	3966589	4034673	2609657	3288168	621499.2	647113.7	364909.2	415864.6					250358.9	350432.9	745997.7	993797.9
DG(38:3)	5670974	6703608	5038002	5809314	1046769	1097484	659290.8	759802.8					545492.9	755992.6	1365275	3034698
DG(38:4)	15964820	19980640	16953670	17479240	4284486	4016263	2777557	3439679					3459677	5089142	7951560	16313520
DG(38:5)	939106.2	1487211	1379985	1386695	511488.8	715704.6	403379.2	490130.8					636428.6	991441.9	1676875	2864306
DG(40:0)	285080.9	454097.1	856672.2	1364535									4779166	1714198	3536923	2255331
DG(40:1)	313382.9	409164	561610.6	937207.2	164663.3	167053.3	115569.1	116167.8					90689.09	112381.2	227605.3	256642.3
DG(40:2)	408870.1	460821.4	405295.8	501728.2	123346.8	148213.2	63534.26	68708.09								
DG(40:3)	331190	396754.2	212303.7	260616.6												
DG(40:4)	1338309	1723660	1786904	1703097	290283.5	329398.3	163942.6	202711.6					189084.8	254603.7	552790.2	902716.7
DG(42:0)				798503.5	88224.09	81688.47	78893.79	73868.38					15199280	5596682	9000679	5830382
DG(42:1)	222139.9	354297.1	526464.2	14963400	98199.15	110202.8	76018.4	72417.87					44864.67	56389.86	123938.3	174712.3
DG(42:2)	142241.9	208652.9	270618	1008072	82379.12	99325.24	50417.52	59480.77					36865.05	46058.48	115207.8	140153.6
DG(46:0)	6474254	9047331	5405535	1928386	79171.83	95005.59	531532.2	616151.6					804083.9	1045352	3971951	5441004
DG(46:1)	917760.2	1392254	1068285	23853050	10501.65	19184.4	201429	198320.1					135725.8	250082.2	1010588	1293834
DG(48:0)	31561300	41670470	23337340	22758700	750874.1	779715.5	2299131	2175060					2044250	2541688	8345354	11942060
DG(48:1)	16334560	22697910	13657590	85953110	314396.7	375287.8	1700768	1651323					1512274	1700730	7413790	10237430
LPE(16:0)					24926.52	46290.92	42443.69	27499.42	45027.59	85192.45	70934.23	92371.48	34318.97	57519.56	72057.77	79857.09
LPE(16:1)					18378.91	47949.88	43192.29	17353.96	8060.01	20526.85	22470.67	23390.31	7403.04	13514.66	11892.2	14200.09
LPE(18:0)					75354.29	72849.54	66184.8	72774.77	28597.5	23710.4	39820.27	42489.03	19239.08	22621.05	44790.8	57509.33
LPE(18:1)	310283.1	948242.8	678893.2	4288666	388635.25	717510.06	797032.75	387940.53	222645.23	355423.72	589128.94	739652.19	189837.42	324993.12	410099.16	458906.72
LPE(20:1)					227567.42	559949.5	634253.75	253754.17	252362.92	459587.12	740852	892695.81	204147.17	362238.53	577413.19	647153.88
LPE(20:2)					23045.16	56811.27	49801.2	26866.41	11191.73	33159.12	45464.83	45999.32	16662.4	23617.92	38100.74	50781.83
LPE(20:3)					34359.53	75391.61	94158.25	32485.51	12253.81	42572.05	65444.42	77970.68	20341.38	37587.44	53846.29	71590.51
LPE(20:4)					96701.99	257956.83	335289.22	151494.06	92497.94	129610.76	178110.33	237259.62	76000.84	138974.5	216449.39	234882.92
LPE(22:1)					11299.51	71462.68	55916.46	9197.6	34782.43	97898.95	108932.57	101760.68	34479.69	60687.03	96140.73	113651.38
LPE(22:2)					6996.69	53526.9	57410.04	21114.49	19725.41	48236.23	52497.52	58409.27	24477.29	52364.83	69366.16	68335.43
LPE(22:3)					30356.43	72095.41	86575.4	34449.92	52615.14	107768.09	66241.09	103486.99	45419.98	89925.05	120878.13	124076.79
LPE(22:4)					153939.2	426074.72	589026.94	267726.28	260289.2	418464.78	473152.72	587669.69	229455.92	377725.38	723230	797853.25
LPE(22:5)					64439.11	200663.33	265730.16	144996.56	93890.59	126582.16	194347.89	246986.11	68540.33	116103.12	243194.73	280014.12
LPE(22:6)					42361.5	105361.79	214486.06	94924.32	42310.96	83777.46	119605.53	129421.75	44678.56	84664.73	128421.62	152175.03
LPE(24:0)					65557.41	83653.06	85252.51	83688.59	0	4126.21	34280.58	35339.45	1853.12	3145.28	10203.06	14454.64
LPE(24:4)					9432.08	28116.76	47495.09	11640.18	15827.36	57917.39	40884.54	64674.26	25773.58	40590.83	83221.47	83514.83
LPE(24:5)					11847.53	37553.67	69193.6	19330.55	30827.95	50696.79	55670.44	71505.52	31748.56	43409.88	73351.12	90473.47
PE(30:0)					176704	270076.09	221248.12	253791.8	110061.91	95153.59	106712.45	117133.66	21280.95	30542.65	31769.79	50482.68
PE(32:0)					1578884.38	1521185.62	430115	472935.41	635055.75	664844.75	272474.41	343232.28	123339.56	174389.17	143030.88	223910.23
PE(32:1)	460424.7	1117594	726676.8	1228830	2142060.75	4132082	1983675.62	2292779.5	415145.78	464286.16	338635.69	392972.25				
PE(34:1)	4338150	10892630	8630987	17012840	23787874	29705504	22098530	23064326	6028216	6822080.5	7271701.5	8192973.5	1725664.88	2004787.5	2055679.62	3113442.75
PE(34:2)					4939240.5	10359855	4757973	5228858	270633.38	330250	236849.19	270526.38	124472.3	159029.44	153533.38	217246.42
PE(36:1)	5670990	14183030	11212300	23046490	21734866	25097274	22569226	22305104	6113729.5	7719773.5	10183217	10966798	1841706.62	2499372.75	3462703	5239492.5
PE(36:2)	3525212	9014484	6772436	13100500	18907330	23723302	17633016	16471008	2429600.5	2715651.75	2464443.75	2993269.75	1034531.5	1450719	1473466.62	2267952
PE(36:3)	175291.5	475377.1	147806	864132.6	870933.56	1402643.38	1586042	1768049.5	191879.2	253681.12	318879.19	374604.62	50994.92	106566.62	135039.14	205992
PE(36:4)	158726.9	423256.3	595255.7	997402.6	2480885.25	4892170.5	4603067.5	5118705.5	453380.84	505346.16	428455.34	584712.06	146250.66	204065.17	250792.67	417428.88
PE(38:1)	168954.6	474117.4	406571.3	953682.8									69187.99	85647.04	132512.3	212887.23
PE(38:2)	364312.8	1298560	1025113	2310269	2102370.75	2759081.75	1902677.88	2050766.62	458119.28	584978.69	565183.62	759358.56	151997.61	200847.92	257056.56	468160.72
PE(38:3)	370862.7	1006533	820837.2	1706949	1409208.88	1886707.12	2378286.5	2331591.25	490112.38	662731.44	862092.25	1129568.38	154599.77	216773.12	371632.78	570858
PE(38:4)	1863306	5186690	5366811	10004020	11066287	18980590	15413968	18619280	3403847.75	4322012	4183233.25	5696232.5	1196876.38	1710222.5	2721808.75	3684569.25
PE(38:5)	151567.2	516991.4	584908.1	926195.1	1892794.5	1996039.5	3381701	3110879.75	451628.03	575466.5	335073.66	433420	75190.49	135165.25	0	0
PE(38:6)	20431.42	40292.41	128289.9	292746.2	1003696.19	2036390.62	3154256	3180655.25	122651.38	91771.23	232184.77	236803.69	59534.89	68377.63	105380.05	112083.04
PE(40:1)	170952	432875	401963.9	1044171	793416.19	833348.31	551428.06	617072.62	267399.66	264366.09	333998	339802.97	86903.21	114699.88	156567.31	243836.25
PE(40:2)	128383.7	402581.7	361164.4	734447									96404.27	124536.16	186167.12	333755.75
PE(40:4)	320943.5	1048532	1281551	2498504	1889989	1723377.12	2969974.25	3000057	611095.56	731216.5	715300.31	912722.31	173771.67	218405.58	543032.44	865131.31
PE(40:5)	101988.6	509331.9	371382.2	1466197	1889781.38	2290982.75	2842258	3145709.75	555789.69	593869.62	685057.56	809834.94	0	0	0	228371.64
PE(40:6)	283783.4	975692.6	1250598	3021980	2674045.75	4052634.75	7296166.5	7763560	1019912.44	1289302	1872367.88	2176606.5	360208.97	479151	731320.44	1125963.62
PE(42:1)	200246.5	515157.8	593952	1475539	526352.19	636774.75	599677.69	619988.31	264723.34	278267.75	476017.38	454201.34	106668.31	143606.61	230234.38	417120.75
PE(42:2)	17697.02	138917.3	137671.7	425822.8	308867.09	312999.75	331509.53	365242.91	121792.88	166947.31	196634.83	216978.44	51859.25	65609.46	115296.04	187672.7
PE(42:4)	20698.71	60925.09	91360.73	167837.1									19410.02	28599.04	67375.73	93135.71
PE(44:4)	27209.72	122654.7	171284.7	456232.3	213601.73	233133	272407.16	256050.75	69948.77	84751.2	119864.19	166022.92	26459.06	33298	65591.12	98051.79
PE(44:5)	6308.62	44945.12	83845.55	217692.4									20648.1	23126.55	54752.58	103285.06
PE(46:6)					25436.87	25722.77	68866.19	65223.14	5896.62	16627.88	34557.71	50284.06	7447.74	10543.95	19814.96	34950.51
PE(O-34:1)					256305.05	228189.81	207451.64	356920.38	103536.32	63100.58	154707.97	180443.48	22074.35	18690.51	55233.02	106751.23
PE(O-36:2)	2966228	7279524	5340638	7744576	6188965.5	6550876.5	6716031.5	8041226	1013982	659094.56	1843806.5	2670749.25	241815.19	144466.28	541162.62	1276599.5
PE(O-36:3)	1678388	4616792	2723538	4055927	2776488.25	3334094	2939866.25	3968852.75	279751.97	161650.73	404503.28	514683.22	72949.53	51586.62	142783.39	319071.62
PE(O-36:5)	1470089	3834476	3477713	5339329	5425427.5	7004531.5	8706903	10366609	696052.25	371222.03	922624.75	1267687.88	213321.27	136334.95	485927.72	1102778.25
PE(O-38:2)	659980.9	1564358	1155434	1947351	1325317.88	1426827.12	1313912	1658664	285319.16	171251.61	552596.31	593610.56	67390.8	43037.85	184168	419031.66
PE(O-38:4)	248893.9	838851.7	946610.9	1978068	1067594.62	1148926	1379947.88	1475039.88	236419.52	62808.92	333380.66	424500.16				
PE(O-38:5)	2266317	5070466	4949562	8308914	4279251.5	4716340.5	6759146.5	7568824	1300508.88	1873993.38	1049019.12	1475283.12	215209.38	151107.14	666409.31	1336931.88
PE(O-38:6)	1096029	2955624	2777422	4366280	3776066.75	5130186.5	7586287.5	8719727	479606.72	248170.61	273591.97	0	153601.86	121636.3	407219.22	934191
PE(O-40:5)	100528.4	441796.3	586472.1	1020918	1134729.88	1478613.62	1772175.5	2321669.5	503842.84	360314.66	501175.16	628426.31	69482.84	39045.89	237605.55	571429.81
PE(O-40:6)	377906.9	1067234	1264801	2078154	1336239.62	1415716.5	2349968	2762789.75	309455.47	176619.94	411593.41	354470.16	75393.38	48291.33	250863.94	493706.34
PG(32:0)					115276.21	121826.34	18568	20097.53	27973.92	35570.89	3600.69	8525.45	27361.01	30263.2	11695.37	16616.35
PG(36:1)					120152.62	198740.98	50481.67	89509.71	26870.76	35630.52	12124.97	9737.68	24196.69	36552.8	32835.61	53267.12
PG(36:2)					22254.87	27146.3	39160.85	33122.91	1606.58	861.11	1905.71	2978.52	4833.32	13467.07	40832.46	59883.07
PI(34:1)	69042.28	229158.2	221406	288907	727412.19	885194.25	777049	871443.5	113289.25	162882.56	217971.86	314116.22	156468.36	193827.56	331661.72	450598.78
PI(36:1)	259272.5	658703	649730.2	859839.2	1402037.88	1771447.62	1097236.25	1174948.88	202573.39	292917.41	507741.38	586199.69	209891.75	273872.03	535969.81	762482.81
PI(36:2)					293880.72	468502.28	379505.59	391438.59	22044.68	33871.02	41753.79	65569.35	66505.94	85922.25	136772.83	196866.7
PI(38:2)	34378.98	106991.5	90880.02	122212.4	203855.11	272711.5	169389.73	192147.08	26181.72	38177.65	68803.41	90545.59	41038.59	48954.76	97725.98	125446.22
PI(38:3)	53086.17	139030.8	114524.9	144698.6	326628.41	444270.12	455332.03	445447.75	65279.55	97175.19	141819.48	186332.83	79028.02	100212.72	251291.02	387721.03
PI(38:4)	76232.93	262320.6	314734.3	435931.1	952405.94	1264918.62	1858212.5	1825563.62	187962.17	313933.78	423147.5	646972.44	419561.25	515439.97	1188508.62	1893614.5
PI(40:4)					58987.1	79202.27	60824.89	89919.71	8186.62	13263.46	19324.46	27897.59	16108.67	14432.41	57988.47	80606.8
TG(42:0)	189452.5	274467.7	241423.2	391477.8	33431.44	45866	87467.15	96743.88					385823.7	567914.8	385823.7	567914.8
TG(44:0)	2197387	2924237	2169265	3413967	71752.45	76768.32	453851.2	452203.4					2438904	3452781	2438904	3452781
TG(44:1)	486529.5	711995.7	534301.1	912980	18006.36	24088.15	181948.5	186757.8					825730.3	1293410	825730.3	1293410
TG(46:0)	13552300	20176180	13492910	22476470	331779.3	356422.5	1699838	1746059					8436649	1.40E+07	8436649	1.40E+07
TG(46:1)	6909056	7991524	6579758	10057980	129884.8	169677.1	1334518	1392566					6994294	9628153	6994294	9628153
TG(46:2)	552162.1	631165.8	531252.7	800443.3	21985.32	28464.95	169844.8	158982.3					869807.3	1163499	869807.3	1163499
TG(48:0)	37063160	54062720	34149150	55670500	1049968	1122243	2924896	3264174					1.38E+07	2.04E+07	1.38E+07	2.04E+07
TG(48:1)	61984350	68290540	46604200	71951590	1051310	1088076	5423840	5826848					3.68E+07	5.18E+07	3.68E+07	5.18E+07
TG(48:2)	8661015	9819688	7086712	11861100	214060.8	254020.4	1180541	1188204					6590176	9835387	6590176	9835387
TG(48:3)	274870.6	303571.9	219059.6	353692.8									446325.2	544041.8	446325.2	544041.8
TG(50:0)	19659320	31162290	28310260	43022240	931520	921617.1	1884168	1779501					7360794	1.22E+07	7360794	1.22E+07
TG(50:1)	162276100	228477300	148151700	255711000	3132370	3764891	1.17E+07	1.34E+07					7.63E+07	1.08E+08	7.63E+07	1.08E+08
TG(50:2)	57012270	68432780	47087380	86363780	1305628	1472526	5609398	5875432					3.84E+07	5.70E+07	3.84E+07	5.70E+07
TG(50:3)	3157509	3254909	2439338	3929149	101282.2	113583.6	476364.5	513927.5					3278466	4647035	3278466	4647035
TG(52:0)	5118900	8275490	8384706	14865500	359722.2	395376.3	559983.8	545526.4					2138743	2785243	2138743	2785243
TG(52:1)	58712000	89317930	66841960	112984900	1523231	1738659	4328614	4813246					2.63E+07	3.43E+07	2.63E+07	3.43E+07
TG(52:2)	195547300	232947800	143327400	243829400	3455421	3817551	1.24E+07	1.25E+07					1.30E+08	1.92E+08	1.30E+08	1.92E+08
TG(52:3)	20038280	24590370	14254470	26657410	533372.2	623130.9	1992131	2102480					1.66E+07	2.15E+07	1.66E+07	2.15E+07
TG(52:4)	797669.9	996954.5	546745.2	989254.1	44574.41	49393.15	143333.8	150420.3					1208727	1737190	1208727	1737190
TG(54:0)	1064805	1394472	2159478	3196079	122067.2	107306.2	187529	159162					1140821	1352753	1140821	1352753
TG(54:1)	9523435	14502600	14822880	22190430	340778.9	358677.8	872739.8	966931.7					4531376	5580074	4531376	5580074
TG(54:2)	47921940	64291410	46477470	76884430	1000870	1065922	3299476	3336672					2.40E+07	3.24E+07	2.40E+07	3.24E+07
TG(54:3)	44653960	51831440	33293300	55660710	954153.3	1045253	3587927	3562865					2.69E+07	3.62E+07	2.69E+07	3.62E+07
TG(54:4)	2885813	3377436	1948277	2935469	116999.6	120184.2	388756.3	412892					3660171	5183362	3660171	5183362
TG(56:0)	809656.7	1127066	1851981	2803015	42296.1	46400.52	85160.17	97933.22					322302.2	402111.9	322302.2	402111.9
TG(56:1)	2476327	2918543	4264349	7096998	68632.15	99240.16	276521.4	276014.8					1256538	1911181	1256538	1911181
TG(56:2)	6120550	7663088	7877282	9816936	164782.3	194186.2	572854.8	564228.8					3762088	4880234	3762088	4880234
TG(56:3)	8827983	9427280	6916746	13624480	171909.7	202288.6	716427.7	729921.5					5321024	8147074	5321024	8147074
TG(56:4)	997971.2	1251685	803669.4	1431227									1299350	1927632	1299350	1927632
TG(56:6)	330811.5	341797.7	283972.2	577762.2									878349.8	1097402	878349.8	1097402
TG(58:0)	515406	794142.2	1431314	2402398									205920.6	262131.4	205920.6	262131.4
TG(58:1)	2283457	3119456	4313328	6963580	66354.19	79798.93	226297.1	228975.3					1013442	1233077	1013442	1233077
TG(58:2)	2651835	3262271	3798385	5899238	90211.1	80639.91	283733	334690.3					2007910	2618079	2007910	2618079
TG(58:3)	1744126	1963745	1675429	3199115	57017.96	59200.29	174337.6	167307.7					1296788	1869670	1296788	1869670
TG(60:0)	201952.6	275434.5	574046.3	992353.7												
TG(60:1)	1145191	1532959	2723675	4169530									589643.1	813608.6	589643.1	813608.6
TG(60:2)	1711389	2214659	2755027	4385410	53879.27	63174.93	204093.5	202582.4					1140114	1790111	1140114	1790111
TG(60:3)	984295.8	1157990	1344613	2035946									866180.4	1097232	866180.4	1097232
TG(62:0)	79547.45	104085.7	235674	353942												
TG(62:1)	553442.1	787249.8	1331861	2051032									268364.1	410241.5	268364.1	410241.5
TG(62:2)	797502.8	946470.4	1476630	2431533	29719.61	26007.08	117163.7	125873.4					587166.8	757394.2	587166.8	757394.2
TG(62:3)	351822.8	423666.5	657904.2	953993.2									442581.6	712652.2	442581.6	712652.2
TG(64:0)	27310.67	40171.26	86670.12	128884.4												
TG(64:1)	511293	667755.6	1116734	1550645									188698.1	276770.9	188698.1	276770.9
TG(64:2)	710657.2	906090.8	1448174	2225374	29476.03	30758.17	118619.4	129216					373598.8	597089.4	373598.8	597089.4
TG(64:3)	253517.5	270353.2	419112	649554									230386.4	345469.7	230386.4	345469.7
TG(66:1)	386022.4	507372.5	587668.8	832371.2									76261.84	138169.4	76261.84	138169.4
TG(66:2)	1029297	1360194	1602800	2740606									420223.8	654998.1	420223.8	654998.1
TG(66:3)	353028.2	435049.4	598702.4	951891.2									260473.2	347967	260473.2	347967
TG(68:2)	689973.7	908093.9	803606.3	1332376									188280.8	274864.8	188280.8	274864.8
TG(68:3)	506131.9	580327.2	647161.7	1045792									223112.1	350339.1	223112.1	350339.1
TG(70:2)	181971.2	209673.6	209726.3	323750.2									90117.46	138079.5	90117.46	138079.5
TG(70:3)	291382.2	379428.8	312245.7	459675									89180.94	137283.6	89180.94	137283.6
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	20190829_pos_wt_1	20190829_pos_wt_2	20190829_pos_KO_1	20190829_pos_KO_2	20191130_pos_rep2_WT_a	20191130_pos_rep2_WT_b	20191130_pos_rep2_KO_a	20191130_pos_rep2_KO_b	20191130_pos_rep3_WT_a	20191130_pos_rep3_WT_b	20191130_pos_rep3_KO_a	20191130_pos_rep3_KO_b	20191230_pos_rep2_WT_a	20191230_pos_rep2_WT_b	20191230_pos_rep2_KO_a	20191230_pos_rep2_KO_b
LPC(16:0)	12817490	21042220	23114680	60232310	896862.19	1498761	1885417.88	1126845.62	635201.5	946461.81	1518444	1741995.38	848463.31	1591263.38	3231538	3255778
LPC(16:1)					118985.66	287302.03	250101	168730.8	28447.76	36633.21	55588.34	77139.62	87555.46	183059.42	329257.28	380004.84
LPC(18:0)					236997.58	233419.75	474942.75	450276	211665.55	130114.41	239820.55	291987.09	165012.67	275812.72	665439.75	746326.25
LPC(18:1)	44950660	55977030	58418160	124804100	1728072.5	3371162	3221535.25	2198726.25	469003.09	585282.44	915444.81	1251556.12	1319158.5	1895717.5	4655653.5	5309140.5
LPC(20:1)	1858519	2587534	4686544	11847360	193395.2	485651.41	561049.69	273244.22	66750.66	102140.55	205427	271357.34	134699.36	205531.8	658163.44	803552
LPC(20:3)					41681.45	88376.2	134406.14	76795.54	12695.06	27495.98	38240.38	56762.72	53731.31	102782.9	316336.84	419419.16
LPC(20:4)					30304.4	66045.35	133127.72	67349.68	27919.59	40837.52	39066.59	53232.91	78346.06	148150.38	427663.28	509254.5
LPC(22:4)					43081.71	105181.22	193668.8	96364.09	35950.71	38201.54	70669.64	55689.28	88365.38	175865.05	759946.31	958495.56
LPC(22:5)					15660.58	46969.09	93384.94	52715.96	13044.62	24400.23	21049.19	36762.07	37166.36	85370.57	315463.22	321223.28
PC(28:0)	3703394	6116016	3741376	4837956	420790.41	495272.38	1147984.88	1176714.88	209858.81	195842.5	275774.97	335154.28	436690.78	593434.94	781298.5	1066240.12
PC(30:0)					15957468	19201410	37547068	38861996	7441903.5	7309737.5	10325760	12871949	7475853.5	10885136	19284336	29158078
PC(30:1)					614985.81	1042649.44	1135654.5	1106839	185839.12	181425.25	167117.25	222290.31	490054.91	868298.06	797231	1057051.88
PC(32:0)					94533160	103877544	92357208	92267752	29637432	30239990	34053420	42143888	20554076	28404110	59853292	87192720
PC(32:1)					42622948	95678472	79168384	84567464	4893128.5	5411833.5	5526769.5	7080448	12464393	23257306	32149734	52461600
PC(32:2)	8181619	14114530	3984606	7829624	884433.56	1708607.5	1062638.88	1111236.62	190959.86	197951.62	130582.15	191141.88	433360.41	843288	663517	960856.06
PC(34:0)	111455900	217274000	203998400	314458800	19270782	21082214	15182684	15410865	4982834.5	5421825.5	6414330.5	7602209.5	3849515	4808012.5	9742071	15543884
PC(34:1)	2272505000	4340337000	3707897000	4600991000	291763552	509904672	448987520	476644192	29640918	37030140	45557840	64284608	54373140	89903848	163312512	271339936
PC(34:2)	183647500	320292100	232551000	280690300	15140064	29585472	27948600	29946134	1811742.38	2415647	1998325.62	2879485	4914909.5	8785652	10702102	18766126
PC(34:3)	6342536	9462690	6008263	5809255	242610.02	528576.94	590506.62	814934.19	80328.56	91109.24	68614.34	93365.73	136167.45	274215.53	325735.72	516424.75
PC(36:1)	413979100	740580000	911568400	1121753000	54296064	75629976	72701688	74769320	5520590.5	8326467.5	10553930	15034823	7211774.5	9851164	22139848	38134480
PC(36:2)	687542000	1206199000	1118709000	1393581000	82910344	132113880	116486808	126063768	5216032.5	7316472	7024682	10665470	12403756	22001976	39173184	74883264
PC(36:3)	34969410	69112620	57326860	73351780	5766890.5	12185796	13678272	14225839	859056.25	925092	978837.5	1463106.88	1490627.12	2630746	5534737.5	8110444.5
PC(36:4)							7112722.5	7826316	633054.31	714101.94		872537	1451973.12	2634963	4829935.5	8182193.5
PC(36:5)	4146965		4282801				296641.78		57270.31				121364.9	217891.52	345239.34	505865.84
PC(38:0)					182618.14	137890.23	107417.07	161358.48	36826.62	46002.25	87033.16	89870.46
PC(38:1)	22378460	35554350	56956930	68003450	2384206	3173022.25	2494914.75	2602023.25	344676.66	440554.03	649494.25	829487.44	283413.16	403055.25	830978.25	1601394.38
PC(38:2)	86763870	143459500	174701500	207110700	10957115	16583109	10853675	13383288	669028.56	1000364.69	1030026.69	1489995	1195476	1951918.5	3137757	5924134.5
PC(38:3)	20922460	36769930	39576730	49972190	3412658.75	5566003	6624128.5	7568442.5	432390.34	515774.38	549821.31	774538.75	573296	958503.31	2233401	4091294
PC(38:4)	11541960	18094100	24423150	24843140	3585283.25	5896951.5	8833779	10145177	755895.69	867330.44	737034.19	1148399.25	983066.06	1703852.88	3324864.75	7802458.5
PC(38:5)						3934206	6423176	6765715.5	525492.31	564378	484897.03	741909	986150.69	1826490	4145126	5677222.5
PC(38:6)					750693.81	1486834.88	3438381.25	3429797.75	278201.66	263334.03	271995.22	381259	542654.19	1080648.12	2050956.38	3811329.25
PC(40:0)	3191496	4812220	9289402	16660680	192648.75	212653.58	177059.58	156878.08	30851.55	41137.85	81308.01	70291.08	27340.79	49411.63	102852.73	141799.22
PC(40:1)	9888901	14885250	21973870	31385980	721732.69	777949.44	518188.22	603633.44	110017.18	122188.77	179197.25	235874.12	79200.55	109819.54	274173.12	470694.16
PC(40:2)	12859440	18843960	28624520	33241640	1066247	1316984.12	1338112.12	1505843.12	103111.32	127292.1	194508.14	265468.91	136709.44	206428.8	433633.5	943111
PC(40:3)	3502222	5355127	6989258	8082937	485149	688755.25	639598.06	666172.19	66742.66	80231.23	79483.06	97359.12	68158.65	112365.88	231636.8	402311.75
PC(40:4)	4427020	7907226	11549810	12778950	1052560.38	1615405.62	1949059.38	2156759.75	179120.55	256446.61	180921.31	280872.88	234241.92	360120.09	948366.06	1753457.88
PC(40:5)	5715300	10198840	18279920	15152220	1441675.5	2632012	3390765.25	4166131	265270.22	235477.8	321903.97	483558.84	408899.75	633147.5	1678732	3244935
PC(40:6)					1025438.31	1485461.38	3373505.25	3620649.75	251022.75	300890.28	280841.16	478870.38	383400.25	627732	1573482.12	2921708.75
PC(40:7)	2785694	3827883	4882220	7107672	255996.88	753838.06	1505530.62	1775647.88	159162.64	167390.75	129764.88	210305	365143.03	724643	1363250.5	1990816
PC(42:0)	1301773	2691189	7224656	10074520	127474.76	142339.64	115206.62	107534.59	13469.67	20974.83	50913.68	61611.45	15293.54	30811.84	64758.79	98373.72
PC(42:1)	8874568	13033710	24479110	39316430	562601.56	605918.25	544649.81	545430.69	76354.59	83623.1	209350.81	200227.3	60136.52	88249.34	250311.12	434203.41
PC(42:2)	7336692	10500410	17677230	24059230	573549.94	655129.81	551155.44	594622.5	47253.62	82487.63	121433.93	168768.31	50153.92	84763.7	246629	425159
PC(44:1)	3400856	5632971	15106080	22024400	259193.38	286983.41	274749	308397.97	24784.48	42683.95	134468.56	128728.38	36094.62	48083.04	127583.84	235860.67
PC(44:2)	3021703	4102493	8207761	10698480	236979.3	251808.3	237211.36	270079.47	13495.2	19097.86	87810.25	110314.74	46668.59	40656.77	119355.97	230198.94
PC(46:1)	2129062	2809222	7751280	12116550	167485.44	169824.23	175639.38	158270.36	18646.04	27007.86	77901.99	80979.92	13217.21	24249.16	82898.9	130914.26
PC(46:2)	1500499	2366356	6896772	9962470	128262.19	165272.08	204653.75	227411.39	16836.62	24122.46	52937.57	83874.57	11760.87	23003.02	104848.72	171938.62
PC(48:1)	519599.5	344508.6	3634748	5107424	172602.33	176010.05	124849.55	125478.97	22208.74	13853.32	71757.93	70734.58
PC(48:2)	2327411	3168625	6326167	10036210	230161.19	233764.2	227731.58	220649.7	18069.51	11012.91	106548.18	121898.19	19620.39	31910.39	107947.99	179022.83
PC(50:2)	3848764	6646691	12404910	17712640	272224.59	297925.59	276953.91	298816.22	20425.88	41349.5	133203.44	131559.47	32539.51	41266.54	144422.09	238711.27
PC(50:3)	416605.3	66506.61	1966692	2047577	50750.88	63971.78	57468.06	66403.78	3906.48	16065.79	22963.98	28112.64
PC(52:2)					154480.08	180401.45	132650.72	182007.67	8217.19	13893.63	56762.12	73810.41
PC(52:6)	866949.6	684162.3	1331396	2587796	91397.9	92594.4	90778.26	103055.41	15989.58	34202.71	42203.5	59343.35	19780.73	25504.34	87110.48	113313.38
PC(52:7)					55248.14	75409.32	82718	90302.71	12733.3	22038.42	37413.21	46821.77	13131.51	21887.25	66384.52	89262.1
PC(54:6)					69703.23	75059.34	52668.36	40828.48	18025.78	10649.22	28538.65	11707.58	10531.15	11418.16	40125.28	41079.79
CE(14:0)	2209315	2317113	1790704	2756680									187043.95	298154.28	155376.31	344326.38
CE(16:0)	2202039	2806286	1327222	2217546	559828.56	752136.19	624791.81	620319.44	488564.75	576353.62	487563.5	450612.97	2202039.25	2806285.75	1327222	2217545.75
CE(16:1)	2579368	3003311	1581363	2444514	791021.56	947134.5	725934	815537.94	632416.44	807917	733399.44	778788.25	2579368.25	3003311	1581362.62	2444514.5
CE(18:0)	997586.9	1454004	737996	1177653									997586.94	1454003.62	737996	1177653.12
CE(18:1)	23549480	28676580	10292300	18224530	5845830.5	6822920	4460913.5	5275058	3948439	4119859	4451862.5	4400211.5	23549482	28676584	10292304	18224526
CE(18:2)	3408408	3972197	2439165	3753830	2109563.25	2455610	1703677.62	1926074	2097175	2689950	1974785.62	2203793	3408408.25	3972196.75	2439165.25	3753830
CE(18:3)	254738.4	236888.3	195266	261547.1	240979.73	259386.7	164115.64	187613.56	191994.61	229191.95	201244.06	235871.42	254738.36	236888.33	195265.95	261547.12
CE(20:1)	2792861	2964162	1331660	2414658	362172.41	358837.88	423431.72	400739.16	293053.34	311124.19	394200.78	377154.34	2792861	2964162	1331659.88	2414657.75
CE(20:2)	581656.3	635965.6	219771.8	411890.2	114307.05	149741.48	136676.64	129326.71	141660.05	175754.64	145343.34	143601.33	581656.31	635965.56	219771.75	411890.22
CE(20:3)	517045.5	558416.3	422231.6	553595.8	346927.22	397507.28	285086.78	404921.72	409565.88	418447.28	371332.38	424059.47	517045.5	558416.31	422231.59	553595.88
CE(20:4)	3426596	2930539	2678816	3052721	2679678.25	3234683.25	2222121.75	2552819.25	2616043.5	2783620	2310961.75	2588163	3426595.75	2930539.25	2678815.75	3052721
CE(20:5)	184074	170724.1	143433.2	221296.8	190790.86	210171.12	169701.83	179407.17	195957.75	188800.52	153258.77	141768.17	184074.02	170724.06	143433.23	221296.77
CE(22:0)	256380.6	330938.1	246406.1	321873.6									126961.4	181159.25	113979.81	209631.5
CE(22:1)	865283.4	1124461	641024.8	1036378	142077.05	161543.45	174776.38	230193.62	137756.02	140787.2	180569.83	182520.05	865283.44	1124461.12	641024.81	1036377.56
CE(22:3)					18167.87	27718.24	42444.78	15738.31	64105.81	53476.33	37157.45	32148.34	85166.12	78688.54	59185.33	103282.41
CE(22:4)					45608.28	77733.56	84096.56	96516.84	146819.94	183012.88	45604.39	72214.71	180495.77	201460.86	104195.96	146317.42
CE(22:6)	1134668	933156.2	854628.1	1363250	564335.12	670729.94	610349.81	673504.5	773084	858436.31	636782.75	648105.94	1134668.12	933156.25	854628.19	1363249.5
CE(24:0)	424684.5	490161.1	449031.3	720570									424684.5	490161.09	449031.28	720570
CE(24:1)	1937608	2259092	1474424	2442284	263483.5	251240.83	394592.72	411715.53	201367.98	187884.55	402429.88	372590.03	1937608	2259092.25	1474424	2442283.75
CE(26:0)	397712.8	441881.6	495555.2	777277.4	41907.9	49833.49	107913.48	128185.26	26472.71	17376.99	83288.6	88320	397712.78	441881.59	495555.22	777277.44
CE(26:1)	1047810	1153751	928869.2	1626741	141363.27	128216.4	276696.62	334298.84	118666.46	104964.19	264154.09	262294.62	1047810	1153750.62	928869.06	1626740.62
CE(28:0)	130278.5	166622	176976.5	281764.4									130278.49	166622.02	176976.55	281764.38
CE(28:1)	574371.6	694135.1	594710.3	962553.8	70330.8	79802.16	168942.2	194985.52	30734.31	51078.37	143686.83	151701.25	574371.56	694135	594710.31	962553.75
CE(30:0)	92205.04	105557.4	89362.91	154244.6									92205.04	105557.43	89362.91	154244.62
CE(30:1)	965653.7	1162356	888319.5	1669988	112811.04	128835.01	276564.28	285007.41	56663.91	77122.13	261846.48	221877.31	965653.69	1162356.5	888319.5	1669988.12
CE(30:2)	51598.47	70894.98	67850.77	100088	3676.86	0	25314.66	24874.77	0	2612.75	23406.65	11010.63	51598.47	70894.98	67850.77	100087.99
CE(32:1)	1835130	2257339	1546558	2452921	272534.66	267722.09	375239.72	497488.34	103734.41	96117.87	303713.44	323826.34	1835129.38	2257339.25	1546557.62	2452920.75
CE(32:2)	184865	182028.7	148407.1	252120.8	31694.71	19376.12	58996.96	53269.23	19181.42	4506.85	58118.91	36793.94	184864.95	182028.67	148407.08	252120.83
CE(34:1)	927617.2	1136863	512762.4	773142.8	150871.75	125122.13	133309.38	159918.3	49117.53	56057.76	104238.51	101012.03	927617.19	1136863.38	512762.41	773142.81
CE(34:2)	191409.5	206942.9	100543.8	162882.1									191409.5	206942.88	100543.84	162882.14
CE(34:4)	72376.93	96616.2	44496.57	71508.06									72376.93	96616.2	44496.57	71508.06
CE(34:5)	182817	215267.3	146802.8	229061.5									182817.02	215267.33	146802.78	229061.5
CE(34:6)	183110.2	191207.9	140443.2	210879.2									183110.2	191207.92	140443.22	210879.2
CE(36:1)	142165.6	154780.1	58925.64	88669.53									142165.62	154780.08	58925.64	88669.53
CE(36:2)	82741.62	92594.62	30011.04	31545.56									82741.62	92594.62	30011.04	31545.56
CE(36:6)	253424.9	296679.6	83691.16	129143.8									253424.92	296679.62	83691.16	129143.75
DG(30:0)	1418516	3057811	1779154	2694845	1088652	1277540	1898137	1945360					1257884	1628480	1889782	3220298
DG(32:0)	7831592	14047660	9550883	14983010	7421246	7243442	4622723	4664206					6295696	7665014	7823938	11324900
DG(32:1)	2137656	3806468	3160694	3789764	2252192	2958905	2128481	2333662					797153.6	992374.2	1445184	2239713
DG(34:0)	6342098	11234130	9734945	12885410	3932152	3775841	3291975	2180906					16352470	7074726	12515980	8690856
DG(34:1)	17025650	24445430	19843780	23686690	9945273	1.29E+07	8427914	8076082					3741535	4973126	7206600	12218570
DG(34:2)	1953020	2639302	2473462	2801402	1149152	1564660	843320.5	976573.6					2199258	1828412	2053608	2214050
DG(36:0)					3309634	1523196	4906032	1252124					53284860	19797060	33329530	20020470
DG(36:1)	18156960	19941100	17346830	20935110	4166531	4268472	2120701	2290674					1267998	1674552	2918663	4257888
DG(36:2)	6461258	10319400	7995918	10610000	3675629	4369036	2347183	2740983					1434818	2000182	2894359	5097493
DG(36:3)	538126.2	651805.4	630972.2	860351.3									210153.8	264698	556760.1	796905.5
DG(36:4)	920535.8	1339512	1053495	1071160									487681.6	687248.5	991714.8	1543628
DG(38:1)	1143682	1256974	1387518	1862715	270344.6	273623.7	189988.3	171565.1
DG(38:2)	3966589	4034673	2609657	3288168	621499.2	647113.7	364909.2	415864.6					250358.9	350432.9	745997.7	993797.9
DG(38:3)	5670974	6703608	5038002	5809314	1046769	1097484	659290.8	759802.8					545492.9	755992.6	1365275	3034698
DG(38:4)	15964820	19980640	16953670	17479240	4284486	4016263	2777557	3439679					3459677	5089142	7951560	16313520
DG(38:5)	939106.2	1487211	1379985	1386695	511488.8	715704.6	403379.2	490130.8					636428.6	991441.9	1676875	2864306
DG(40:0)	285080.9	454097.1	856672.2	1364535									4779166	1714198	3536923	2255331
DG(40:1)	313382.9	409164	561610.6	937207.2	164663.3	167053.3	115569.1	116167.8					90689.09	112381.2	227605.3	256642.3
DG(40:2)	408870.1	460821.4	405295.8	501728.2	123346.8	148213.2	63534.26	68708.09
DG(40:3)	331190	396754.2	212303.7	260616.6
DG(40:4)	1338309	1723660	1786904	1703097	290283.5	329398.3	163942.6	202711.6					189084.8	254603.7	552790.2	902716.7
DG(42:0)				798503.5	88224.09	81688.47	78893.79	73868.38					15199280	5596682	9000679	5830382
DG(42:1)	222139.9	354297.1	526464.2	14963400	98199.15	110202.8	76018.4	72417.87					44864.67	56389.86	123938.3	174712.3
DG(42:2)	142241.9	208652.9	270618	1008072	82379.12	99325.24	50417.52	59480.77					36865.05	46058.48	115207.8	140153.6
DG(46:0)	6474254	9047331	5405535	1928386	79171.83	95005.59	531532.2	616151.6					804083.9	1045352	3971951	5441004
DG(46:1)	917760.2	1392254	1068285	23853050	10501.65	19184.4	201429	198320.1					135725.8	250082.2	1010588	1293834
DG(48:0)	31561300	41670470	23337340	22758700	750874.1	779715.5	2299131	2175060					2044250	2541688	8345354	11942060
DG(48:1)	16334560	22697910	13657590	85953110	314396.7	375287.8	1700768	1651323					1512274	1700730	7413790	10237430
LPE(16:0)					24926.52	46290.92	42443.69	27499.42	45027.59	85192.45	70934.23	92371.48	34318.97	57519.56	72057.77	79857.09
LPE(16:1)					18378.91	47949.88	43192.29	17353.96	8060.01	20526.85	22470.67	23390.31	7403.04	13514.66	11892.2	14200.09
LPE(18:0)					75354.29	72849.54	66184.8	72774.77	28597.5	23710.4	39820.27	42489.03	19239.08	22621.05	44790.8	57509.33
LPE(18:1)	310283.1	948242.8	678893.2	4288666	388635.25	717510.06	797032.75	387940.53	222645.23	355423.72	589128.94	739652.19	189837.42	324993.12	410099.16	458906.72
LPE(20:1)					227567.42	559949.5	634253.75	253754.17	252362.92	459587.12	740852	892695.81	204147.17	362238.53	577413.19	647153.88
LPE(20:2)					23045.16	56811.27	49801.2	26866.41	11191.73	33159.12	45464.83	45999.32	16662.4	23617.92	38100.74	50781.83
LPE(20:3)					34359.53	75391.61	94158.25	32485.51	12253.81	42572.05	65444.42	77970.68	20341.38	37587.44	53846.29	71590.51
LPE(20:4)					96701.99	257956.83	335289.22	151494.06	92497.94	129610.76	178110.33	237259.62	76000.84	138974.5	216449.39	234882.92
LPE(22:1)					11299.51	71462.68	55916.46	9197.6	34782.43	97898.95	108932.57	101760.68	34479.69	60687.03	96140.73	113651.38
LPE(22:2)					6996.69	53526.9	57410.04	21114.49	19725.41	48236.23	52497.52	58409.27	24477.29	52364.83	69366.16	68335.43
LPE(22:3)					30356.43	72095.41	86575.4	34449.92	52615.14	107768.09	66241.09	103486.99	45419.98	89925.05	120878.13	124076.79
LPE(22:4)					153939.2	426074.72	589026.94	267726.28	260289.2	418464.78	473152.72	587669.69	229455.92	377725.38	723230	797853.25
LPE(22:5)					64439.11	200663.33	265730.16	144996.56	93890.59	126582.16	194347.89	246986.11	68540.33	116103.12	243194.73	280014.12
LPE(22:6)					42361.5	105361.79	214486.06	94924.32	42310.96	83777.46	119605.53	129421.75	44678.56	84664.73	128421.62	152175.03
LPE(24:0)					65557.41	83653.06	85252.51	83688.59	0	4126.21	34280.58	35339.45	1853.12	3145.28	10203.06	14454.64
LPE(24:4)					9432.08	28116.76	47495.09	11640.18	15827.36	57917.39	40884.54	64674.26	25773.58	40590.83	83221.47	83514.83
LPE(24:5)					11847.53	37553.67	69193.6	19330.55	30827.95	50696.79	55670.44	71505.52	31748.56	43409.88	73351.12	90473.47
PE(30:0)					176704	270076.09	221248.12	253791.8	110061.91	95153.59	106712.45	117133.66	21280.95	30542.65	31769.79	50482.68
PE(32:0)					1578884.38	1521185.62	430115	472935.41	635055.75	664844.75	272474.41	343232.28	123339.56	174389.17	143030.88	223910.23
PE(32:1)	460424.7	1117594	726676.8	1228830	2142060.75	4132082	1983675.62	2292779.5	415145.78	464286.16	338635.69	392972.25
PE(34:1)	4338150	10892630	8630987	17012840	23787874	29705504	22098530	23064326	6028216	6822080.5	7271701.5	8192973.5	1725664.88	2004787.5	2055679.62	3113442.75
PE(34:2)					4939240.5	10359855	4757973	5228858	270633.38	330250	236849.19	270526.38	124472.3	159029.44	153533.38	217246.42
PE(36:1)	5670990	14183030	11212300	23046490	21734866	25097274	22569226	22305104	6113729.5	7719773.5	10183217	10966798	1841706.62	2499372.75	3462703	5239492.5
PE(36:2)	3525212	9014484	6772436	13100500	18907330	23723302	17633016	16471008	2429600.5	2715651.75	2464443.75	2993269.75	1034531.5	1450719	1473466.62	2267952
PE(36:3)	175291.5	475377.1	147806	864132.6	870933.56	1402643.38	1586042	1768049.5	191879.2	253681.12	318879.19	374604.62	50994.92	106566.62	135039.14	205992
PE(36:4)	158726.9	423256.3	595255.7	997402.6	2480885.25	4892170.5	4603067.5	5118705.5	453380.84	505346.16	428455.34	584712.06	146250.66	204065.17	250792.67	417428.88
PE(38:1)	168954.6	474117.4	406571.3	953682.8									69187.99	85647.04	132512.3	212887.23
PE(38:2)	364312.8	1298560	1025113	2310269	2102370.75	2759081.75	1902677.88	2050766.62	458119.28	584978.69	565183.62	759358.56	151997.61	200847.92	257056.56	468160.72
PE(38:3)	370862.7	1006533	820837.2	1706949	1409208.88	1886707.12	2378286.5	2331591.25	490112.38	662731.44	862092.25	1129568.38	154599.77	216773.12	371632.78	570858
PE(38:4)	1863306	5186690	5366811	10004020	11066287	18980590	15413968	18619280	3403847.75	4322012	4183233.25	5696232.5	1196876.38	1710222.5	2721808.75	3684569.25
PE(38:5)	151567.2	516991.4	584908.1	926195.1	1892794.5	1996039.5	3381701	3110879.75	451628.03	575466.5	335073.66	433420	75190.49	135165.25	0	0
PE(38:6)	20431.42	40292.41	128289.9	292746.2	1003696.19	2036390.62	3154256	3180655.25	122651.38	91771.23	232184.77	236803.69	59534.89	68377.63	105380.05	112083.04
PE(40:1)	170952	432875	401963.9	1044171	793416.19	833348.31	551428.06	617072.62	267399.66	264366.09	333998	339802.97	86903.21	114699.88	156567.31	243836.25
PE(40:2)	128383.7	402581.7	361164.4	734447									96404.27	124536.16	186167.12	333755.75
PE(40:4)	320943.5	1048532	1281551	2498504	1889989	1723377.12	2969974.25	3000057	611095.56	731216.5	715300.31	912722.31	173771.67	218405.58	543032.44	865131.31
PE(40:5)	101988.6	509331.9	371382.2	1466197	1889781.38	2290982.75	2842258	3145709.75	555789.69	593869.62	685057.56	809834.94	0	0	0	228371.64
PE(40:6)	283783.4	975692.6	1250598	3021980	2674045.75	4052634.75	7296166.5	7763560	1019912.44	1289302	1872367.88	2176606.5	360208.97	479151	731320.44	1125963.62
PE(42:1)	200246.5	515157.8	593952	1475539	526352.19	636774.75	599677.69	619988.31	264723.34	278267.75	476017.38	454201.34	106668.31	143606.61	230234.38	417120.75
PE(42:2)	17697.02	138917.3	137671.7	425822.8	308867.09	312999.75	331509.53	365242.91	121792.88	166947.31	196634.83	216978.44	51859.25	65609.46	115296.04	187672.7
PE(42:4)	20698.71	60925.09	91360.73	167837.1									19410.02	28599.04	67375.73	93135.71
PE(44:4)	27209.72	122654.7	171284.7	456232.3	213601.73	233133	272407.16	256050.75	69948.77	84751.2	119864.19	166022.92	26459.06	33298	65591.12	98051.79
PE(44:5)	6308.62	44945.12	83845.55	217692.4									20648.1	23126.55	54752.58	103285.06
PE(46:6)					25436.87	25722.77	68866.19	65223.14	5896.62	16627.88	34557.71	50284.06	7447.74	10543.95	19814.96	34950.51
PE(O-34:1)					256305.05	228189.81	207451.64	356920.38	103536.32	63100.58	154707.97	180443.48	22074.35	18690.51	55233.02	106751.23
PE(O-36:2)	2966228	7279524	5340638	7744576	6188965.5	6550876.5	6716031.5	8041226	1013982	659094.56	1843806.5	2670749.25	241815.19	144466.28	541162.62	1276599.5
PE(O-36:3)	1678388	4616792	2723538	4055927	2776488.25	3334094	2939866.25	3968852.75	279751.97	161650.73	404503.28	514683.22	72949.53	51586.62	142783.39	319071.62
PE(O-36:5)	1470089	3834476	3477713	5339329	5425427.5	7004531.5	8706903	10366609	696052.25	371222.03	922624.75	1267687.88	213321.27	136334.95	485927.72	1102778.25
PE(O-38:2)	659980.9	1564358	1155434	1947351	1325317.88	1426827.12	1313912	1658664	285319.16	171251.61	552596.31	593610.56	67390.8	43037.85	184168	419031.66
PE(O-38:4)	248893.9	838851.7	946610.9	1978068	1067594.62	1148926	1379947.88	1475039.88	236419.52	62808.92	333380.66	424500.16
PE(O-38:5)	2266317	5070466	4949562	8308914	4279251.5	4716340.5	6759146.5	7568824	1300508.88	1873993.38	1049019.12	1475283.12	215209.38	151107.14	666409.31	1336931.88
PE(O-38:6)	1096029	2955624	2777422	4366280	3776066.75	5130186.5	7586287.5	8719727	479606.72	248170.61	273591.97	0	153601.86	121636.3	407219.22	934191
PE(O-40:5)	100528.4	441796.3	586472.1	1020918	1134729.88	1478613.62	1772175.5	2321669.5	503842.84	360314.66	501175.16	628426.31	69482.84	39045.89	237605.55	571429.81
PE(O-40:6)	377906.9	1067234	1264801	2078154	1336239.62	1415716.5	2349968	2762789.75	309455.47	176619.94	411593.41	354470.16	75393.38	48291.33	250863.94	493706.34
PG(32:0)					115276.21	121826.34	18568	20097.53	27973.92	35570.89	3600.69	8525.45	27361.01	30263.2	11695.37	16616.35
PG(36:1)					120152.62	198740.98	50481.67	89509.71	26870.76	35630.52	12124.97	9737.68	24196.69	36552.8	32835.61	53267.12
PG(36:2)					22254.87	27146.3	39160.85	33122.91	1606.58	861.11	1905.71	2978.52	4833.32	13467.07	40832.46	59883.07
PI(34:1)	69042.28	229158.2	221406	288907	727412.19	885194.25	777049	871443.5	113289.25	162882.56	217971.86	314116.22	156468.36	193827.56	331661.72	450598.78
PI(36:1)	259272.5	658703	649730.2	859839.2	1402037.88	1771447.62	1097236.25	1174948.88	202573.39	292917.41	507741.38	586199.69	209891.75	273872.03	535969.81	762482.81
PI(36:2)					293880.72	468502.28	379505.59	391438.59	22044.68	33871.02	41753.79	65569.35	66505.94	85922.25	136772.83	196866.7
PI(38:2)	34378.98	106991.5	90880.02	122212.4	203855.11	272711.5	169389.73	192147.08	26181.72	38177.65	68803.41	90545.59	41038.59	48954.76	97725.98	125446.22
PI(38:3)	53086.17	139030.8	114524.9	144698.6	326628.41	444270.12	455332.03	445447.75	65279.55	97175.19	141819.48	186332.83	79028.02	100212.72	251291.02	387721.03
PI(38:4)	76232.93	262320.6	314734.3	435931.1	952405.94	1264918.62	1858212.5	1825563.62	187962.17	313933.78	423147.5	646972.44	419561.25	515439.97	1188508.62	1893614.5
PI(40:4)					58987.1	79202.27	60824.89	89919.71	8186.62	13263.46	19324.46	27897.59	16108.67	14432.41	57988.47	80606.8
TG(42:0)	189452.5	274467.7	241423.2	391477.8	33431.44	45866	87467.15	96743.88					385823.7	567914.8	385823.7	567914.8
TG(44:0)	2197387	2924237	2169265	3413967	71752.45	76768.32	453851.2	452203.4					2438904	3452781	2438904	3452781
TG(44:1)	486529.5	711995.7	534301.1	912980	18006.36	24088.15	181948.5	186757.8					825730.3	1293410	825730.3	1293410
TG(46:0)	13552300	20176180	13492910	22476470	331779.3	356422.5	1699838	1746059					8436649	1.40E+07	8436649	1.40E+07
TG(46:1)	6909056	7991524	6579758	10057980	129884.8	169677.1	1334518	1392566					6994294	9628153	6994294	9628153
TG(46:2)	552162.1	631165.8	531252.7	800443.3	21985.32	28464.95	169844.8	158982.3					869807.3	1163499	869807.3	1163499
TG(48:0)	37063160	54062720	34149150	55670500	1049968	1122243	2924896	3264174					1.38E+07	2.04E+07	1.38E+07	2.04E+07
TG(48:1)	61984350	68290540	46604200	71951590	1051310	1088076	5423840	5826848					3.68E+07	5.18E+07	3.68E+07	5.18E+07
TG(48:2)	8661015	9819688	7086712	11861100	214060.8	254020.4	1180541	1188204					6590176	9835387	6590176	9835387
TG(48:3)	274870.6	303571.9	219059.6	353692.8									446325.2	544041.8	446325.2	544041.8
TG(50:0)	19659320	31162290	28310260	43022240	931520	921617.1	1884168	1779501					7360794	1.22E+07	7360794	1.22E+07
TG(50:1)	162276100	228477300	148151700	255711000	3132370	3764891	1.17E+07	1.34E+07					7.63E+07	1.08E+08	7.63E+07	1.08E+08
TG(50:2)	57012270	68432780	47087380	86363780	1305628	1472526	5609398	5875432					3.84E+07	5.70E+07	3.84E+07	5.70E+07
TG(50:3)	3157509	3254909	2439338	3929149	101282.2	113583.6	476364.5	513927.5					3278466	4647035	3278466	4647035
TG(52:0)	5118900	8275490	8384706	14865500	359722.2	395376.3	559983.8	545526.4					2138743	2785243	2138743	2785243
TG(52:1)	58712000	89317930	66841960	112984900	1523231	1738659	4328614	4813246					2.63E+07	3.43E+07	2.63E+07	3.43E+07
TG(52:2)	195547300	232947800	143327400	243829400	3455421	3817551	1.24E+07	1.25E+07					1.30E+08	1.92E+08	1.30E+08	1.92E+08
TG(52:3)	20038280	24590370	14254470	26657410	533372.2	623130.9	1992131	2102480					1.66E+07	2.15E+07	1.66E+07	2.15E+07
TG(52:4)	797669.9	996954.5	546745.2	989254.1	44574.41	49393.15	143333.8	150420.3					1208727	1737190	1208727	1737190
TG(54:0)	1064805	1394472	2159478	3196079	122067.2	107306.2	187529	159162					1140821	1352753	1140821	1352753
TG(54:1)	9523435	14502600	14822880	22190430	340778.9	358677.8	872739.8	966931.7					4531376	5580074	4531376	5580074
TG(54:2)	47921940	64291410	46477470	76884430	1000870	1065922	3299476	3336672					2.40E+07	3.24E+07	2.40E+07	3.24E+07
TG(54:3)	44653960	51831440	33293300	55660710	954153.3	1045253	3587927	3562865					2.69E+07	3.62E+07	2.69E+07	3.62E+07
TG(54:4)	2885813	3377436	1948277	2935469	116999.6	120184.2	388756.3	412892					3660171	5183362	3660171	5183362
TG(56:0)	809656.7	1127066	1851981	2803015	42296.1	46400.52	85160.17	97933.22					322302.2	402111.9	322302.2	402111.9
TG(56:1)	2476327	2918543	4264349	7096998	68632.15	99240.16	276521.4	276014.8					1256538	1911181	1256538	1911181
TG(56:2)	6120550	7663088	7877282	9816936	164782.3	194186.2	572854.8	564228.8					3762088	4880234	3762088	4880234
TG(56:3)	8827983	9427280	6916746	13624480	171909.7	202288.6	716427.7	729921.5					5321024	8147074	5321024	8147074
TG(56:4)	997971.2	1251685	803669.4	1431227									1299350	1927632	1299350	1927632
TG(56:6)	330811.5	341797.7	283972.2	577762.2									878349.8	1097402	878349.8	1097402
TG(58:0)	515406	794142.2	1431314	2402398									205920.6	262131.4	205920.6	262131.4
TG(58:1)	2283457	3119456	4313328	6963580	66354.19	79798.93	226297.1	228975.3					1013442	1233077	1013442	1233077
TG(58:2)	2651835	3262271	3798385	5899238	90211.1	80639.91	283733	334690.3					2007910	2618079	2007910	2618079
TG(58:3)	1744126	1963745	1675429	3199115	57017.96	59200.29	174337.6	167307.7					1296788	1869670	1296788	1869670
TG(60:0)	201952.6	275434.5	574046.3	992353.7
TG(60:1)	1145191	1532959	2723675	4169530									589643.1	813608.6	589643.1	813608.6
TG(60:2)	1711389	2214659	2755027	4385410	53879.27	63174.93	204093.5	202582.4					1140114	1790111	1140114	1790111
TG(60:3)	984295.8	1157990	1344613	2035946									866180.4	1097232	866180.4	1097232
TG(62:0)	79547.45	104085.7	235674	353942
TG(62:1)	553442.1	787249.8	1331861	2051032									268364.1	410241.5	268364.1	410241.5
TG(62:2)	797502.8	946470.4	1476630	2431533	29719.61	26007.08	117163.7	125873.4					587166.8	757394.2	587166.8	757394.2
TG(62:3)	351822.8	423666.5	657904.2	953993.2									442581.6	712652.2	442581.6	712652.2
TG(64:0)	27310.67	40171.26	86670.12	128884.4
TG(64:1)	511293	667755.6	1116734	1550645									188698.1	276770.9	188698.1	276770.9
TG(64:2)	710657.2	906090.8	1448174	2225374	29476.03	30758.17	118619.4	129216					373598.8	597089.4	373598.8	597089.4
TG(64:3)	253517.5	270353.2	419112	649554									230386.4	345469.7	230386.4	345469.7
TG(66:1)	386022.4	507372.5	587668.8	832371.2									76261.84	138169.4	76261.84	138169.4
TG(66:2)	1029297	1360194	1602800	2740606									420223.8	654998.1	420223.8	654998.1
TG(66:3)	353028.2	435049.4	598702.4	951891.2									260473.2	347967	260473.2	347967
TG(68:2)	689973.7	908093.9	803606.3	1332376									188280.8	274864.8	188280.8	274864.8
TG(68:3)	506131.9	580327.2	647161.7	1045792									223112.1	350339.1	223112.1	350339.1
TG(70:2)	181971.2	209673.6	209726.3	323750.2									90117.46	138079.5	90117.46	138079.5
TG(70:3)	291382.2	379428.8	312245.7	459675									89180.94	137283.6	89180.94	137283.6
METABOLITES_END
#END