#METABOLOMICS WORKBENCH purdylab_20230101_124221 DATATRACK_ID:3679 STUDY_ID:ST002422 ANALYSIS_ID:AN003944 PROJECT_ID:PR001559 VERSION 1 CREATED_ON January 3, 2023, 10:19 am #PROJECT PR:PROJECT_TITLE UBXD8 lipidomics from MAM fraction PR:PROJECT_SUMMARY The intimate association between the endoplasmic reticulum (ER) and PR:PROJECT_SUMMARY mitochondrial membranes at ER-mitochondria contact sites (ERMCS) serves as a PR:PROJECT_SUMMARY platform for several critical cellular processes, in particular lipid synthesis. PR:PROJECT_SUMMARY Enzymes involved in lipid biosynthesis are enriched at contacts and membrane PR:PROJECT_SUMMARY lipid composition at contacts is distinct relative to surrounding membranes. How PR:PROJECT_SUMMARY contacts are remodeled and the subsequent biological consequences of altered PR:PROJECT_SUMMARY contacts such as perturbed lipid metabolism remains poorly understood. Here we PR:PROJECT_SUMMARY investigate if the ER-tethered ubiquitin-X domain adaptor 8 (UBXD8) regulates PR:PROJECT_SUMMARY the lipids found in mitochondria-associated membranes (MAM). LC-MS/MS lipidomics PR:PROJECT_SUMMARY found significant changes in distinct lipid species in the MAM fraction of UBXD8 PR:PROJECT_SUMMARY knockout cells. Our results suggest that lipids in MAM are regulated by UBXD8. PR:INSTITUTE University of Arizona PR:DEPARTMENT Immunobiology PR:LABORATORY Purdy Lab PR:LAST_NAME Purdy PR:FIRST_NAME John PR:ADDRESS PO Box 245221, Tucson, Arizona, 85724, USA PR:EMAIL purdylab@gmail.com PR:PHONE 520-626-4371 PR:FUNDING_SOURCE NIH R01 AI162671 PR:CONTRIBUTORS Rakesh Ganji, Joao A. Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S. PR:CONTRIBUTORS Clemen, Conrad C. Weihl, John G. Purdy, Steve P. Gygi, and Malavika Raman #STUDY ST:STUDY_TITLE UBXD8 lipidomics from whole cells (Part 2) ST:STUDY_SUMMARY The intimate association between the endoplasmic reticulum (ER) and ST:STUDY_SUMMARY mitochondrial membranes at ER-mitochondria contact sites (ERMCS) serves as a ST:STUDY_SUMMARY platform for several critical cellular processes, in particular lipid synthesis. ST:STUDY_SUMMARY Enzymes involved in lipid biosynthesis are enriched at contacts and membrane ST:STUDY_SUMMARY lipid composition at contacts is distinct relative to surrounding membranes. How ST:STUDY_SUMMARY contacts are remodeled and the subsequent biological consequences of altered ST:STUDY_SUMMARY contacts such as perturbed lipid metabolism remains poorly understood. Here we ST:STUDY_SUMMARY investigate if the ER-tethered ubiquitin-X domain adaptor 8 (UBXD8) regulates ST:STUDY_SUMMARY the lipids found in mitochondria-associated membranes (MAM). LC-MS/MS lipidomics ST:STUDY_SUMMARY found significant changes in distinct lipid species in the MAM fraction of UBXD8 ST:STUDY_SUMMARY knockout cells. Our results suggest that lipids in MAM are regulated by UBXD8. ST:INSTITUTE University of Arizona ST:DEPARTMENT Immunobiology ST:LABORATORY Purdy Lab ST:LAST_NAME Purdy ST:FIRST_NAME John ST:ADDRESS PO Box 245221, Tucson, Arizona, 85724, USA ST:EMAIL purdylab@gmail.com ST:PHONE 520-626-4371 #SUBJECT SU:SUBJECT_TYPE Cultured cells SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:CELL_STRAIN_DETAILS HEK293T #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - 20220508_neg_KO_rep1_10ul Description:UBXD8 Knockout | inj vol:10 RAW_FILE_NAME=20220508_neg_KO_rep1_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_neg_KO_rep3_10ul Description:UBXD8 Knockout | inj vol:10 RAW_FILE_NAME=20220508_neg_KO_rep3_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_neg_KO_rep4_10ul Description:UBXD8 Knockout | inj vol:10 RAW_FILE_NAME=20220508_neg_KO_rep4_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_neg_WT_rep1_10ul Description:Wild-type | inj vol:10 RAW_FILE_NAME=20220508_neg_WT_rep1_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_neg_WT_rep3_10ul Description:Wild-type | inj vol:10 RAW_FILE_NAME=20220508_neg_WT_rep3_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_neg_WT_rep4_10ul Description:Wild-type | inj vol:10 RAW_FILE_NAME=20220508_neg_WT_rep4_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep1_4ul Description:UBXD8 Knockout | inj vol:4 RAW_FILE_NAME=20220508_pos_KO_rep1_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep1_8ul Description:UBXD8 Knockout | inj vol:8 RAW_FILE_NAME=20220508_pos_KO_rep1_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep1_16ul Description:UBXD8 Knockout | inj vol:16 RAW_FILE_NAME=20220508_pos_KO_rep1_16ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep3_4ul Description:UBXD8 Knockout | inj vol:4 RAW_FILE_NAME=20220508_pos_KO_rep3_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep3_8ul Description:UBXD8 Knockout | inj vol:8 RAW_FILE_NAME=20220508_pos_KO_rep3_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep3_16ul Description:UBXD8 Knockout | inj vol:16 RAW_FILE_NAME=20220508_pos_KO_rep3_16ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep4_4ul Description:UBXD8 Knockout | inj vol:4 RAW_FILE_NAME=20220508_pos_KO_rep4_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep4_8ul Description:UBXD8 Knockout | inj vol:8 RAW_FILE_NAME=20220508_pos_KO_rep4_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_KO_rep4_16ul Description:UBXD8 Knockout | inj vol:16 RAW_FILE_NAME=20220508_pos_KO_rep4_16ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep1_4ul Description:Wild-type | inj vol:4 RAW_FILE_NAME=20220508_pos_WT_rep1_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep1_8ul Description:Wild-type | inj vol:8 RAW_FILE_NAME=20220508_pos_WT_rep1_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep1_16ul Description:Wild-type | inj vol:16 RAW_FILE_NAME=20220508_pos_WT_rep1_16ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep3_4ul Description:Wild-type | inj vol:4 RAW_FILE_NAME=20220508_pos_WT_rep3_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep3_8ul Description:Wild-type | inj vol:8 RAW_FILE_NAME=20220508_pos_WT_rep3_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep3_16ul Description:Wild-type | inj vol:16 RAW_FILE_NAME=20220508_pos_WT_rep3_16ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep4_4ul Description:Wild-type | inj vol:4 RAW_FILE_NAME=20220508_pos_WT_rep4_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep4_8ul Description:Wild-type | inj vol:8 RAW_FILE_NAME=20220508_pos_WT_rep4_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220508_pos_WT_rep4_16ul Description:Wild-type | inj vol:16 RAW_FILE_NAME=20220508_pos_WT_rep4_16ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_neg_rep8_KO_5ul Description:UBXD8 Knockout | inj vol:5 RAW_FILE_NAME=20220820_tufts_MAMfrac_neg_rep8_KO_5ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_neg_rep8_KO_10ul Description:UBXD8 Knockout | inj vol:10 RAW_FILE_NAME=20220820_tufts_MAMfrac_neg_rep8_KO_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_neg_rep8_KO_15ul Description:UBXD8 Knockout | inj vol:15 RAW_FILE_NAME=20220820_tufts_MAMfrac_neg_rep8_KO_15ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_neg_rep8_WT_5ul Description:Wild-type | inj vol:5 RAW_FILE_NAME=20220820_tufts_MAMfrac_neg_rep8_WT_5ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_neg_rep8_WT_10ul Description:Wild-type | inj vol:10 RAW_FILE_NAME=20220820_tufts_MAMfrac_neg_rep8_WT_10ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_neg_rep8_WT_15ul Description:Wild-type | inj vol:15 RAW_FILE_NAME=20220820_tufts_MAMfrac_neg_rep8_WT_15ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_pos_rep8_KO_4ul Description:UBXD8 Knockout | inj vol:4 RAW_FILE_NAME=20220820_tufts_MAMfrac_pos_rep8_KO_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_pos_rep8_KO_8ul Description:UBXD8 Knockout | inj vol:8 RAW_FILE_NAME=20220820_tufts_MAMfrac_pos_rep8_KO_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_pos_rep8_KO_16ul Description:UBXD8 Knockout | inj vol:16 RAW_FILE_NAME=20220820_tufts_MAMfrac_pos_rep8_KO_16ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_pos_rep8_WT_4ul Description:Wild-type | inj vol:4 RAW_FILE_NAME=20220820_tufts_MAMfrac_pos_rep8_WT_4ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_pos_rep8_WT_8ul Description:Wild-type | inj vol:8 RAW_FILE_NAME=20220820_tufts_MAMfrac_pos_rep8_WT_8ul.mzXML SUBJECT_SAMPLE_FACTORS - 20220820_tufts_MAMfrac_pos_rep8_WT_16ul Description:Wild-type | inj vol:16 RAW_FILE_NAME=20220820_tufts_MAMfrac_pos_rep8_WT_16ul.mzXML #COLLECTION CO:COLLECTION_SUMMARY Cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM), CO:COLLECTION_SUMMARY supplemented with 10% fetal bovine serum (FBS) and 100 units/mL penicillin and CO:COLLECTION_SUMMARY streptomycin. Cells were maintained in a humidified, 5 % CO2 atmosphere at CO:COLLECTION_SUMMARY 37°C. The CRISPR-Cas9 gene editing system was used to generate UBXD8 knockout CO:COLLECTION_SUMMARY cell lines in HEK293T cells. Cells were seeded into four 150 mm TC dishes. Cells CO:COLLECTION_SUMMARY were lysed in Homogenization buffer (225 mM mannitol, 75 mM sucrose, and 30 mM CO:COLLECTION_SUMMARY Tris-Cl, pH 7.4) using a Dounce homogenizer. The lysate was centrifuged three CO:COLLECTION_SUMMARY times at 600xg for 5 minutes to remove unlysed cells and nuclei resulting in CO:COLLECTION_SUMMARY post-nuclear supernatants (PNS). The cleared lysate was centrifuged at 7000xg to CO:COLLECTION_SUMMARY separate crude mitochondrial pellet and supernatant containing microsomes. The CO:COLLECTION_SUMMARY supernatant was cleared by centrifugation at 20,000xg for 30 minutes followed by CO:COLLECTION_SUMMARY microsome isolation using high-speed centrifugation at 100,000xg for 1 hour. The CO:COLLECTION_SUMMARY crude mitochondrial pellet was washed twice in homogenization buffer containing CO:COLLECTION_SUMMARY 0.1 mM EGTA at 7000xg and 10,000xg for 10 minutes. MAMs were isolated from crude CO:COLLECTION_SUMMARY mitochondria using 30 % Percoll gradient centrifugation at 95,000xg for 1 hr in CO:COLLECTION_SUMMARY a swinging-bucket rotor. The banded MAM fraction was washed once with CO:COLLECTION_SUMMARY phosphate-buffered saline (PBS) before lysing in lysis buffer (50 mM Tris-Cl, pH CO:COLLECTION_SUMMARY 7.2, 150 mM NaCl). The pure mitochondrial fractions were resuspended and washed CO:COLLECTION_SUMMARY in mitochondrial resuspension buffer (250 mM mannitol, 0.5 mM EGTA, 5 mM HEPES CO:COLLECTION_SUMMARY pH7.4). Protein concentrations for both soluble and pellet fractions were CO:COLLECTION_SUMMARY determined by DC protein assay kit (Biorad). For lipidomics of MAMs, the final CO:COLLECTION_SUMMARY banded MAM fraction was washed twice with liquid chromatography-mass CO:COLLECTION_SUMMARY spectrometry (LC-MS) grade PBS and the final MAM pellet was resuspended in LC-MS CO:COLLECTION_SUMMARY grade PBS. Next, 1mL of cold 50% methanol was added and the MAMS were CO:COLLECTION_SUMMARY transferred to glass vials. Chloroform was added (0.5mL) and the mixture was CO:COLLECTION_SUMMARY gently vortexed and centrifuged at 1,000x g for 5 min at 4˚C. Lipids were CO:COLLECTION_SUMMARY transferred to a clean glass vial using a glass Hamilton syringe. Lipids were CO:COLLECTION_SUMMARY extracted twice using chloroform prior to being dried under nitrogen gas. CO:COLLECTION_SUMMARY Samples were normalized according to protein concentration. Extracted lipids CO:COLLECTION_SUMMARY were resuspended in a 1:1:1 solution of methanol:chloroform:isopropanol prior to CO:COLLECTION_SUMMARY mass spectrometry (MS) analysis. CO:SAMPLE_TYPE Epithelial cells #TREATMENT TR:TREATMENT_SUMMARY Wild-type vs UBXD8 Knockout #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Lipids were isolated from collected cultured cells. Cells were washed with PBS, SP:SAMPLEPREP_SUMMARY treated with cold 50% methanol (1mL) and transferred to glass vials. Next, SP:SAMPLEPREP_SUMMARY chloroform (0.5mL) was added and samples were gently vortexed and centrifuged at SP:SAMPLEPREP_SUMMARY 1,000x g for 5 min at 4˚C. Lipids were transferred to a clean glass vial using SP:SAMPLEPREP_SUMMARY a glass Hamilton syringe. Lipids were extracted twice using chloroform prior to SP:SAMPLEPREP_SUMMARY being dried under nitrogen gas. Samples were normalized according to protein SP:SAMPLEPREP_SUMMARY concentration when resuspended in a 1:1:1 solution of SP:SAMPLEPREP_SUMMARY methanol:chloroform:isopropanol prior to mass spectrometry (MS) analysis. To SP:SAMPLEPREP_SUMMARY assist quantification various volumes were injected for MS (4, 8, and 16ul for SP:SAMPLEPREP_SUMMARY positive mode analysis and 5, 10, and 15ul for negative mode analysis). #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Lipids were identified and quantitatively measured using ultra high-performance CH:CHROMATOGRAPHY_SUMMARY liquid-chromatography high-resolution tandem MS/MS (UHPLC-MS/MS) as recently CH:CHROMATOGRAPHY_SUMMARY described89,90. Separation of lipids was done by reverse-phase chromatography CH:CHROMATOGRAPHY_SUMMARY using a Waters ACQUITY CSH C18 column (150x2.1mm; 1.7um) at 60°C using a CH:CHROMATOGRAPHY_SUMMARY Vanquish UHPLC system (Thermo Scientific) and two solvents: solvent A (40:60 CH:CHROMATOGRAPHY_SUMMARY water-methanol plus 10mM ammonium formate and 0.1% formic acid) and solvent B CH:CHROMATOGRAPHY_SUMMARY (10:90 methanol-isopropanol plus 10mM ammonium formate and 0.1% formic acid). CH:CHROMATOGRAPHY_SUMMARY UHPLC was performed at a 0.25 ml per min flow rate for 30 min per sample, CH:CHROMATOGRAPHY_SUMMARY starting at 25% solvent B and ending at 100% solvent B as described. The column CH:CHROMATOGRAPHY_SUMMARY was washed and equilibrated between samples. Samples were run in a semi-random CH:CHROMATOGRAPHY_SUMMARY order where WT or UBXD8 KO samples were interspersed with blank samples. Each CH:CHROMATOGRAPHY_SUMMARY sample was repeatedly analyzed using various injection volumes (4, 8, 16ul for CH:CHROMATOGRAPHY_SUMMARY positive mode and 5, 10, and 15ul for negative mode). CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Vanquish CH:COLUMN_NAME Waters ACQUITY UPLC CSH C18 (150 x 2.1mm,1.7um) CH:SOLVENT_A 40% water; 60% methanol 10mM ammonium formate and 0.1% formic acid CH:SOLVENT_B 10% methanol; 90% isopropanol 10mM ammonium formate and 0.1% formic acid CH:FLOW_GRADIENT 25% to 100% CH:FLOW_RATE 0.25mL per min CH:COLUMN_TEMPERATURE 60 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS Samples were run in a semi-random order where WT or UBXD8 KO samples were MS:MS_COMMENTS interspersed with blank samples. Lipids were ionized using a heated electrospray MS:MS_COMMENTS ionization (HESI) source and nitrogen gas and measured using a Q-Exactive Plus MS:MS_COMMENTS mass spectrometer operating at a MS1 resolution of either 70,000 or 140,000 and MS:MS_COMMENTS a MS2 resolution of 35,000. MS1 Spectra were collected over a mass range of 200 MS:MS_COMMENTS to 1,600 m/z with an automatic gain control (AGC) setting of 1e6 and transient MS:MS_COMMENTS times of 250 ms (70,000 resolution) or 520 ms (140,000 resolution). MS2 spectra MS:MS_COMMENTS were collected using a transient time of 120 ms and an AGC setting of 1e5. Each MS:MS_COMMENTS sample was analyzed using negative and positive ion modes. The mass analyzer was MS:MS_COMMENTS calibrated weekly. SPLASH LIPIDOMIX mass spectrometry standards (Avanti Polar MS:MS_COMMENTS Lipids) were used in determining extraction efficiencies and lipid quantitation. MS:MS_COMMENTS Lipids were identified and quantified using MAVEN, and El-MAVEN (Elucidata). MS:MS_COMMENTS UHPLC retention time, MS1 peaks, and MS2 fragments were used to identify lipids. MS:MS_COMMENTS Lipids were included if they were observed in 3-6 samples in both UBXD8 KO and MS:MS_COMMENTS WT cells. Missing values in a sample were not imputed. The following lipid MS:MS_COMMENTS classes were included in the analysis: cholesteryl esters (CE), diacylglycerol MS:MS_COMMENTS (DG), phosphatidylcholine (PC), phosphatidylethanolamine (PE), MS:MS_COMMENTS phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylserine (PS), MS:MS_COMMENTS and triacylglycerol (TG). Guidelines from the Lipidomic Standards Initiative MS:MS_COMMENTS were followed for lipid species identification and quantification, including MS:MS_COMMENTS consideration of isotopic patterns resulting from naturally occurring 13C atoms MS:MS_COMMENTS and isomeric overlap. The following MS2 information was used to confirm each MS:MS_COMMENTS lipid species: PC fragment of 184.073 (positive mode) and tail identification MS:MS_COMMENTS using formic adduct (negative mode); PE fragment of 196.038 or the tail plus MS:MS_COMMENTS 197.046 (negative mode) and neutral loss (NL) of 141.019 (positive mode); PG MS:MS_COMMENTS fragment of 152.996 plus the identification of the FA tails (negative mode) and MS:MS_COMMENTS NL 189.04 of [M+NH4]+ adduct (positive mode); PI fragment of 241.012 (negative) MS:MS_COMMENTS and NL 277.056 of [M+NH4]+ adduct (positive mode); PS NL of 87.032 (negative); MS:MS_COMMENTS DG and TG by NL of FA tails (positive mode); and CE fragment of 369.352 or MS:MS_COMMENTS neutral loss of 368.35 (positive). #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS peak area MS_METABOLITE_DATA_START Samples 20220508_pos_KO_rep1_4ul 20220508_pos_KO_rep3_4ul 20220508_pos_KO_rep4_4ul 20220508_pos_KO_rep1_8ul 20220508_pos_KO_rep3_8ul 20220508_pos_KO_rep4_8ul 20220508_pos_KO_rep1_16ul 20220508_pos_KO_rep3_16ul 20220508_pos_KO_rep4_16ul 20220508_pos_WT_rep1_4ul 20220508_pos_WT_rep3_4ul 20220508_pos_WT_rep4_4ul 20220508_pos_WT_rep1_8ul 20220508_pos_WT_rep3_8ul 20220508_pos_WT_rep4_8ul 20220508_pos_WT_rep1_16ul 20220508_pos_WT_rep3_16ul 20220508_pos_WT_rep4_16ul 20220820_tufts_MAMfrac_pos_rep8_WT_4ul 20220820_tufts_MAMfrac_pos_rep8_WT_8ul 20220820_tufts_MAMfrac_pos_rep8_WT_16ul 20220820_tufts_MAMfrac_pos_rep8_KO_4ul 20220820_tufts_MAMfrac_pos_rep8_KO_8ul 20220820_tufts_MAMfrac_pos_rep8_KO_16ul Factors Description:UBXD8 Knockout | inj vol:4 Description:UBXD8 Knockout | inj vol:4 Description:UBXD8 Knockout | inj vol:4 Description:UBXD8 Knockout | inj vol:8 Description:UBXD8 Knockout | inj vol:8 Description:UBXD8 Knockout | inj vol:8 Description:UBXD8 Knockout | inj vol:16 Description:UBXD8 Knockout | inj vol:16 Description:UBXD8 Knockout | inj vol:16 Description:Wild-type | inj vol:4 Description:Wild-type | inj vol:4 Description:Wild-type | inj vol:4 Description:Wild-type | inj vol:8 Description:Wild-type | inj vol:8 Description:Wild-type | inj vol:8 Description:Wild-type | inj vol:16 Description:Wild-type | inj vol:16 Description:Wild-type | inj vol:16 Description:Wild-type | inj vol:4 Description:Wild-type | inj vol:8 Description:Wild-type | inj vol:16 Description:UBXD8 Knockout | inj vol:4 Description:UBXD8 Knockout | inj vol:8 Description:UBXD8 Knockout | inj vol:16 CE(16:0) 393477.28 665367.94 831400.06 348325.88 682535.81 861567.31 CE(16:1) 136345.61 41118.15 63762.69 293875.78 93477.71 131314.58 403820.78 126857.69 195064.77 161412.42 204277.02 91830.87 314206.5 457296.84 211830.33 546837.75 653363.94 318897.94 569970.25 1120316 1320605.62 240656.38 552138.5 633715.81 CE(18:1) 1122427.88 277995.38 407523.25 2343360 537186.31 923008 2736671.25 1020955.31 1416456.62 1415202.38 1764921.62 721122.69 3122456.75 3817384 1566658.5 4645244.5 5438359 2484470.25 4377441.5 9380143 10427111 1862277 3462956 4282025 CE(18:2) 114390.26 46555.64 101402.35 219558.08 92136.09 217561.95 278984.69 200902.45 319655.84 134209.89 132407.83 92259.59 298390.38 266704.16 190203.58 457560.84 379760.16 344270.12 403314.38 825440.31 1120367 221845.08 483882.5 623251.94 CE(18:3) 32742.27 74933.92 108887.18 17484.45 44023 65501.01 CE(20:1) 150150.11 26917.25 45638.04 301027.31 75387.59 90472.53 430249.66 119282.84 165148.39 167495.59 206469.83 82763.68 409004.97 406291.12 161958.25 559523.56 664096.56 255502.3 571394.81 1148599.12 1355615.38 188426 418188.84 603845.94 CE(20:4) 75118.38 35327.39 79081.19 171704.81 79543.62 161234.77 234118.55 125568.84 242909.19 87317.73 73742.91 60353.36 171507.89 153562.91 136859.55 250766.19 188724.55 205068.45 304707.59 610637.56 728806.81 193759.7 449628 561514.94 CE(22:1) 66061.14 15016.21 19569.53 127899.77 27912.44 43302.75 177951.7 58142.12 70690.07 70434.45 73597.8 25069.7 154795.88 169725.62 60812 229698.56 272890.53 112701.65 177244.11 360992.91 531469 74212.82 153220.77 225223.05 CE(22:6) 46236.25 16976.67 43346.02 100292.84 35277.3 92699.35 116058.84 66175.14 123513.7 33900.41 46578.09 43564.16 87547.81 98710.81 70737.3 125324.38 140786.14 117022.96 166347.08 355456.59 463236.91 114771.65 198252.06 222941 CE(24:0) 33902.38 2962.68 6610.52 73104.82 12672.01 21690.99 113015.62 29537.86 35026.78 21335.8 16945.08 6650.99 47029.05 38544.33 16873.52 64737.59 69367.99 32070.75 46250.88 104216.9 142494.98 97270.77 194520.45 309664.16 CE(24:1) 127201.21 28793.72 38692.89 268233.47 67925.09 84748.35 399303.84 121726.95 144282.64 115341.84 133606.27 46203.77 250449.95 289163.16 119934.47 431811.09 479002.09 195986.38 251338.58 531498.5 764652.81 151140.14 327934.62 472000.09 CE(26:0) 29711.39 0 4694.91 73926.05 6947.05 10292.25 116793.76 11538.72 25205.96 13333.22 8749.88 1639.8 38509.44 31275.34 10920.96 59712.18 40239.25 11069.68 34535.33 81779.02 118062.79 93477.15 228875.8 347542 CE(26:1) 73101.42 15819.62 17102.23 152080.95 41856.99 43588.89 256381.17 80126.84 90577.21 63778.39 75450.24 32187.8 147298.02 157163.42 54484.58 233809.89 255386.12 98102.29 125013.81 237664 374220.62 90848.62 216734.52 292656.38 CE(28:0) 11853.31 27945.05 39832.64 26954.41 69256.15 115472.55 CE(28:1) 36556.16 10970.22 7074.67 90622.3 22131.38 26680.58 138675.05 56912.12 50320.77 36560.86 38248.9 15231.92 80364.73 85362.52 32341.2 135188.17 152803.27 52353.25 69444.82 128191.49 225878.94 54239.95 115279.49 192263.5 CE(30:1) 70578.44 17846.62 22954.75 147235.61 34361.89 36220.55 245335.39 74095.22 74879.38 63498.62 44232.88 21876.26 119864.88 126386.07 53628.55 232459.94 232366.89 88730.32 104988.69 213594.39 332181.5 79887.63 166419.7 273481.31 CE(32:1) 95780.54 25814.53 25060.73 211214.12 64026.32 51325.64 391022 113121.57 111242.02 100950.04 103000.55 30851.77 234925.31 206463.42 68912.2 415237.12 355110.78 140738.95 161641.55 337652.91 553359 101530.05 241949.95 383677.66 CE(34:1) 32204.44 9525.25 8689.65 75080.57 18244.03 18470.21 112034.34 39158.07 35835.45 53861.43 37398.52 13300.65 110173.69 81246.01 30240.67 190606.38 135510.11 56126.82 61862.67 142653.14 241443.81 39046.29 74541.41 122360.84 CE(34:5) 20006.42 42540.81 65449.62 3880.12 14146.8 21851.61 CE(36:6) 22177.22 45982.67 75271.66 2455.06 10320.58 13812.71 DG(28:0) 482498.09 910067.69 735612.94 605884.94 864915.25 1073684.12 DG(30:0) 5063128.5 7776742.5 8027193.5 6384642 10587717 11178700 DG(30:1) 676383.5 1222199.75 1063721.25 565731.06 1087821.88 872201.5 DG(32:0) 12548928 24775078 25533838 20330248 34064360 40849544 DG(32:1) 2188091.75 687561.19 1904331.88 4479184.5 1377022.12 3808427.25 5246642.5 2139083.5 5033192 3006870.25 1619398.62 1967710.88 6262438 3462679.25 3999429 8477867 4391049.5 5561639.5 6742404.5 13034281 14423421 7924642.5 14320089 13722200 DG(34:1) 6863018.5 2003137.5 5491191.5 13129296 4335501.5 10864925 15668496 6248578 13561043 11325084 5012041.5 5207517.5 23399394 9911226 10744501 26707664 11989457 14065493 21908086 43214252 55696972 27478280 46856700 56933664 DG(34:2) 934615.69 362780.53 828224 1934304.5 706020.81 1645200.62 2406239.25 1085303.12 2131407.25 1455586.12 1097308.12 1181755.38 2904470.25 2232179.5 2440421.25 3727167.25 2695128.25 3133192.75 4305926.5 6866269.5 8393925 2585705.25 4854396.5 5392342.5 DG(36:1) 2613232.75 953678.19 1240831.62 5709019.5 1782942.12 2543195 6648466 3307178.75 3299743.75 3285257.25 1764443.38 1002587.81 7537782 3706162.25 2112212 9851444 4466616 2712355.25 5348697.5 10330540 11871632 7314598.5 13455667 15497409 DG(36:2) 2171354 779101.06 1841063.88 4567528 1656297.88 3752590 5373810.5 2585393 4935869.5 3554878.75 2058209.5 2042459 7960550 4302747 4205974 9936092 5190292.5 5604196 8400188 16869054 19406402 6162110.5 11267275 11602715 DG(36:3) 443532.25 923942 1101821.38 351507.97 540127.12 726970.75 DG(38:1) 466599.91 969661.44 1350746.62 758041.19 1531411.12 1832795.62 DG(38:2) 346088.38 109189.59 229549.2 704165.25 283366.59 519973.5 976142.44 579461.81 787789.81 434859.62 219602.17 212882.36 1036513.94 494840.03 456232.22 1692089.38 853792.31 681174.81 1157933.25 2109090.25 2973598 892375.75 1755911.5 1930221.12 DG(38:4) 380784.25 315004.78 163828.89 798274.81 691475.81 343422.34 913234.25 1059989.5 432744.62 573642.94 674360.31 198118.56 1158459.62 1319617 414875.22 1512116.62 1692442.5 564041.06 594105.94 950612.31 1464347.38 364413.66 614831.44 824295.56 DG(40:1) 96541.1 38780.3 70976.55 218840.44 84079.37 144672.94 284649.72 136460.69 246225.81 87393.69 29172.29 35939.91 222558.19 68534.63 75735.26 308289.5 100170.31 133196.08 262585.22 517066.97 692164.94 520524.41 1096707.5 1424717.5 DG(40:2) 53645.38 22662.02 52711.19 121663.72 48812.43 99444.96 170151.25 90069.9 162847.16 58345.39 32777.48 42613.49 164370.03 86105.35 89703.72 230459.67 121964.06 127703.12 186218.17 357854.53 443954.34 170156.77 279785.53 395702 DG(42:0) 116337 243136.67 304550 590136.44 1235472.62 1431608.62 DG(42:1) 72367.01 18170.69 57647.73 160331.56 53535.34 101659.16 208657.05 92348.41 177694.94 57833.08 24220.3 22406.03 133185.08 47722.96 53940.59 193713.95 59668.06 87700.38 140498.44 298850.69 389027.75 334999.34 697000 934907.25 DG(42:2) 40498.48 16592.84 40885.46 89040.38 39138.33 84048.66 109679.75 66367.09 117824.19 42956.27 24570.24 25220.9 95057.12 45293.7 56879.14 132354.86 65459.98 90031.19 114828.62 229326 307765.97 117522.91 263250.38 311639.72 DG(44:0) 26219.09 5499.77 15020.06 53151.34 18683.35 37016.19 58253.04 27979.73 44130.58 9198.57 3153.11 4099.14 34157.66 4120.57 9160.06 43314.98 7708.03 14205.68 28619.49 62270.46 90080.94 156268.83 318295.38 388729.62 DG(44:1) 40540.84 14944.65 37812.58 80755.41 29773.16 68848.05 105529.82 48606.16 103672.73 21080.67 8904.31 10523.28 47354.29 21595.31 26804.48 72774.79 25874.76 39848.93 55001.05 124169.5 172159.98 168267.55 321683.12 434318.75 DG(44:2) 16734.79 9019.37 18921.78 36494.05 17405.13 37747.82 41623.02 22392.34 58982.18 16028.26 6034.38 11034.01 39050.83 17983.21 26050.52 51834.57 20515.28 34294.25 42279.52 86035.62 106739.38 62372.89 113667.97 141820.98 DG(46:0) 19897.36 48180.52 35688.82 69638.13 165988.02 211649.3 DG(46:1) 27946.02 11112.68 28799.73 62010.31 26620.39 62700.95 96391.34 47949.17 101973.66 30301.81 9916.68 11186.53 62279.85 18140.78 25664.58 82872.3 34053.93 47470.32 80396.73 158072.7 217717.95 163457.69 341488.91 436302.91 DG(46:2) 25787.37 52233.81 68860.8 35188.94 63675.22 86446.43 DG(48:1) 57849.78 10610.07 42199.72 136616.03 32081.62 94089.32 198127.58 81845.4 161860.08 55516.16 19406.74 14746.96 114539.98 40791.66 44836.82 208634 79127.3 53739.43 144588.66 324027.06 494957.97 268737.53 620121.5 783887.56 DG(48:2) 22714.2 12082.41 28344.97 58764.61 25449.95 56077.42 76918.5 44920.37 78681.52 19851.38 5646.05 15789.29 44557.98 27008.68 34523.31 68504.7 35749.41 51417.83 46124.31 91462.38 130474.66 53648.05 134434.64 179165.89 TG(44:0) 870094.5 1960920.38 2556882 1202911.62 2598826.25 3302041 TG(44:1) 225197.69 448167.88 597456.25 191486.86 423421.84 519304 TG(46:0) 3914738 8875525 12353201 6514408.5 14114059 18367940 TG(46:1) 2095269.38 4154957 5621685.5 1907502.88 4228018 5509303.5 TG(46:2) 239430.95 467329.88 661398.69 122481.96 262480.66 386483.34 TG(48:0) 7768224 17161314 23754010 14923711 32485246 42881188 TG(48:1) 2198247 520934.12 645602.94 4907496 1141063.5 1368276.88 6784262 1822679.62 2128652.25 2122405.75 2641401.25 1228614.5 4570746.5 5666422.5 2633846.25 7248502.5 7624950.5 4276011.5 11545164 23559368 31322944 12312203 25368602 32713718 TG(48:2) 604044.81 167374.56 144778.69 1159390.38 314866.78 312187.56 1703419.5 570666.38 488493.66 566746.5 1095770.88 351443.03 1253849.88 2372896 769645.31 1842658 3489878.75 1350214.12 2076349.38 4507632 6165585.5 1188851.12 2558893.25 3437146.25 TG(48:3) 118043.98 249915.17 371698.38 45209.48 96756.68 136267.19 TG(50:0) 5061910 12881029 15672595 13743723 30681166 38075780 TG(50:1) 5538036 1027114.31 1664328.62 12960768 2389855.75 3486635 16870136 4069440 5694784.5 6805906 5058100.5 2218363.75 13541584 9409521 4898355.5 19798976 15050227 8031034 24734998 53938748 63214364 29883926 60570012 81298976 TG(50:2) 3195306 695851.06 848428.56 7012858 1374183.88 1686589.62 10442159 2755359.5 2760125 3728228 4277933 1415420.12 7746810 10313219 3228213 12866688 16039319 5235428 11253336 21307390 31022794 6399499.5 13315613 19616182 TG(50:3) 276213.56 74408.81 64651.16 627325.69 159869.09 149017.98 984770 302323.88 245364.95 365247.53 551536.25 193027.67 748832.69 1326801.25 399605.53 1307827.62 2001499.5 710268.31 969207.56 2113236.25 3408391.75 381179.03 804450.94 1294244.12 TG(52:0) 2058419.88 4613330.5 6427624.5 4910565.5 11410749 14143371 TG(52:1) 3253634 527366.62 753848.94 7403302.5 1165015.12 1791086.12 10474747 2146812.25 3024923.75 3190484 1873531 881361 7611658.5 4254057.5 1996588.88 11280200 6554056.5 3456546.25 12992328 25835554 37213260 18102042 39940896 49939700 TG(52:2) 7334873.5 1326879.5 1831778.5 16695075 3161975.75 4208848.5 23241490 5733668.5 6883018 9246017 7933054 2556794.25 19935690 17110152 5440480 30769104 25875088 9395561 22672142 50344716 65710848 14985788 30887698 44088960 TG(52:3) 4598078.5 10132304 14903953 1660569.5 3757998.25 5551442.5 TG(54:1) 718118 121020.04 177461.31 1507464.5 268908.62 403369 2476023.75 526905.31 738784.69 557867.25 285201.59 144734.08 1216263.75 667131.56 351995.59 2181105.25 1046871.69 588171 2541516 5600326 8426900 4019095.25 9590521 13688653 TG(54:2) 2299871.75 409944 579276.19 5574249 920717 1209302 8608582 1739677.88 2230986.5 2471263 1898117.12 634843.44 6016725.5 4418445 1464882.38 9538048 7542672.5 2764189.25 7037408 16158312 22000982 5742496 11739992 16380851 TG(54:3) 3040927 540373.56 625072.5 6521125.5 1230584.62 1312059.38 9496674 2121219 2341972 3860508.75 2872061.75 840219.69 9009803 6778334 1837045.5 13871009 10281197 3513611.25 8665736 18254266 25907806 2982738 6257451.5 9338155 TG(54:4) 547626.62 1179883.75 1912884.62 224862.69 420482.03 685863.06 TG(56:0) 284119.66 643498.12 871913.75 906218.44 2237552 3300322 TG(56:1) 245223.42 48974.59 75125.54 496944.16 101504.31 153777.69 829471.31 222962.56 275891.66 177212.31 95203.05 61284.41 377278.34 213426.69 130736.12 637303.44 384255.41 251401.86 686328.06 1615603.38 2543874.25 1148204.62 2837407.25 4299608.5 TG(56:2) 473168.41 86655.18 122141.09 994384.94 183272.36 264181.38 1759105 342237.5 483603.41 396726.03 298002.34 120590.5 883142.5 733983.06 278331.16 1598909.88 1233555.5 472605.5 1270072.12 2674983.25 4505829 972219.19 2263859.25 3625528.75 TG(56:3) 606022.06 105318.09 125467.46 1455229.88 237905.98 265329.59 2298740.25 439546.28 523591.47 715901.31 489696.41 142139.25 1696298.62 1215515.5 349344.94 2768147.25 2062523.62 669684.5 1889675.12 4171715.75 5990839.5 677676.19 1459547.62 2192441.25 TG(56:4) 66836.77 11257.57 16000.36 138687.23 33731.54 35446.17 253794.08 62304.16 68459.88 73840.05 71165.78 22253.33 182222.33 152182.48 45678.02 322847.41 298095.47 92741.31 203169.83 427602.91 740316.25 75029.41 191176.62 314329.47 TG(58:0) 195201.81 423981.34 618583.69 668342.56 1619244.38 2601084 TG(58:1) 236297.38 44136.02 67249.6 511161.22 90213.98 132822.95 852999.81 187760.83 260532.3 148278.88 85305.38 48112.07 336614.97 203460.05 102137.94 575708.44 333810.75 206595.38 526109.69 1190678.12 1815148.62 1047162.81 2324013.75 4031763.25 TG(58:2) 261827.86 53861.5 70099.59 524765.75 121110.66 168619.55 947353.69 218391.94 302446.91 200483.27 181869.19 69070.3 442080.53 373186.5 144570.61 785171.06 665743.5 316729.59 633003.5 1275340 2332203 509534 1256137.88 1994136 TG(58:3) 161325.14 37509.08 39675.2 346801.81 69307.56 77732.41 577721.44 119275.15 161949.27 177706.58 138972.08 49292.82 413612.28 335736.88 106718.29 655758.94 586475.81 192844.23 503221.84 1036508 1633732.62 188353.33 427460.12 607385.38 TG(60:0) 81380.09 170121 256662.31 269348.59 653175.19 1051693.12 TG(60:1) 135905.19 29948.41 39433.52 314171 64086.89 94486.21 528463.75 126690.54 176207.27 84732.41 55910.94 24515.53 166708.05 114428.81 61504.5 335437.75 192440.12 110945.27 302967.12 647198.31 1023469.31 565560.81 1336602.38 2215311.75 TG(60:2) 183441.25 40371.6 46230.19 437726 77364.75 106767.72 692228.5 155291.62 211041.62 121185.22 115478.72 43773.41 289586.38 242664.48 94393.18 509502.75 431147.41 195665.33 364415.38 841812.94 1339360.88 385768.97 816524.5 1393514.75 TG(60:3) 104263.62 25999.84 23400.63 219583.3 45987.89 64065.27 387805.91 100440.31 112642.85 109779.34 87459.34 39223.88 229297.02 214713.3 74958.41 383828.5 385953.34 145557.88 273438.66 576497.44 890260.19 109545.48 262106.64 426835.84 TG(62:0) 26911.65 55034.03 91833.78 94820.46 212607.8 364512.09 TG(62:1) 81576.24 12084.27 21959.82 150559.67 34438.44 60536.89 283708.97 81737.9 102672.75 44802.39 27171.1 21453.4 97152.12 52823.51 27077.69 161397.95 85107.07 63224.64 181947.25 364607.22 676355.69 302984.72 730975.75 1266991.38 TG(62:2) 104740.69 20086.28 37448.79 237153.75 52815.11 67476.4 412337.91 103645.47 132267.81 66454.41 56298.89 24028.59 147547.03 133841.84 53639.47 279488.53 239996.56 110754.62 192853.25 418117.09 745332.25 201931.02 470370.41 780490 TG(62:3) 55465.47 13011.34 16338.71 130168.71 21207.63 33597.36 193301.19 49611.04 67156.68 39900.29 37078.02 16294.63 100155.99 93219.48 32843.22 169203.7 168469.33 64770.97 101244.75 255147.17 425700.5 45090.08 121981.13 204047.3 TG(64:1) 67086.86 12833.9 25313.06 133233.62 32357.56 41729.45 265018.16 73899.86 97114.73 52717.1 25817.24 16691.52 118625.21 57364.53 35065.94 211953.88 97116.91 65194.14 172086.58 395835.03 664583.81 282951.97 605901.81 1096489.5 TG(64:2) 91396.65 23210.51 34752.47 221665.67 64637.47 67299.98 368447.5 112257.51 142338.48 77240.2 63218.39 30597.26 143238.22 137627.58 64898.91 272975.5 240975.3 107262.41 215102.27 439663.5 764739.06 183092.62 455960.59 734519.5 TG(64:3) 42638.59 12260.92 13029.76 90994.97 24637.37 25498.75 143594.36 48717.61 52194.44 29092.4 34661.96 11300.25 60662.68 67206.3 19613.79 110983.4 116960.02 54686.55 69995.71 150716.36 286656.56 35873.55 78302.02 129876.79 TG(66:1) 41712.78 5004.47 12476.72 76563.97 19641.15 26531.76 149752.39 45544.19 52048.19 39226.86 12145.75 9489.74 76007.14 31589.6 18264.38 158796.31 56959.56 32225.23 109058.91 237026.75 470130.84 140023.39 335607.84 561710.56 TG(66:2) 104697.62 32528.43 27420.26 236821.33 57515.34 72783.49 443641.09 131230.81 146023 104335.04 63023.29 30917.58 232575.17 157521.45 65852.27 403799.66 278939.81 133246.56 256438.83 574397.81 986298.56 177960.75 453389.53 815762.69 TG(68:2) 47098.12 13364.54 18578.52 117687.54 28098.89 35021.01 225990.52 61226.88 62123.05 73772.78 36591.18 13696.6 152953.64 77239.48 31355.29 265826.72 139022.73 69990.6 144276.19 322184.38 636191.81 90896.12 210875.05 315386.41 TG(68:3) 72650.88 14206.61 12201.18 135359.64 32836.73 38741.91 226095.23 67617.27 78771.26 63438.78 41076.11 17469.74 138990.73 88674.29 35652.56 261422.86 185228.2 70019.87 113217.69 247258.14 445303.41 42993.41 107142.9 174280.08 TG(70:2) 12124.94 2087.61 2428.65 29892.07 6956.48 11161.23 54328.86 16729.29 20369.45 13562.07 7652.32 2230.86 35135.56 19727.39 6012.46 76478.41 39589.69 19543.69 37952.29 95073.87 175859.52 25250.66 49478.47 91523.46 TG(70:3) 17387.03 5488.64 5989.12 62422.97 13593.63 15732.84 105534.16 33698.47 25339.24 41569.64 24356.99 6646.4 78697.41 38557.34 15052.06 150673.67 89079.97 36592.02 63927.32 139347.41 252086.55 17641.87 45058.79 79398.12 LPC(16:0) 31066630 6414895.5 12408235 36105436 8485069 15639973 49217136 14342797 25393926 33088742 9123111 9652891 43041012 12196816 14114732 57514580 17301450 23089342 10994053 14869195 19061288 17464508 23448128 29598890 LPC(18:0) 9002597 1268337.62 1883053.88 14740948 2362716.25 3333449.25 17477002 3599220 4531444.5 7348322.5 1474784.88 1402194 11110522 2512916.5 2525628.5 14549769 3363510.75 3776855.25 2096804 3350368.25 5101995 4387898.5 7295880 10072265 LPC(18:1) 13407899 2625422 4975345 17858376 5243918 8397302 23192766 8922376 13758745 15567593 6131526.5 4713162.5 20872598 10555113 7618442.5 28618278 16813798 13444973 5055298.5 7142185.5 11770155 4087162 5915106 9882797 LPC(20:1) 3652544 635669.56 890185.5 3920423 895707.69 1096154.12 4976750.5 1489616.88 1749868.38 2926676.75 637230.25 751800.81 4152558 862060.75 752762.56 5289306 1419251.62 1478841.88 561229.94 910313.56 1516909.12 553739.12 922222.5 1518409.88 LPC(22:0) 22325.41 49384 102665.81 59213.63 136437.58 244382.42 LPC(24:0) 575263.75 59622.76 57282.41 831167 82674.18 86934.46 1538244 132191.8 131835.39 290073.53 47181.53 37276.94 383021.25 71776.81 64283.59 770453.44 116535.85 108491.13 58147.31 135272.2 332892.78 184252.5 423271.09 938888 LPC(24:1) 473428.47 60124.07 69474.49 636610.75 101688.81 87411.21 880504.69 118871.31 130074.63 307654.72 54666.54 55366.72 428513.12 80666.76 65203.83 579738 113217.23 101340.63 41479.86 122947.28 230538.7 80803.23 131910.72 365518.25 PC(28:0) 2449624.75 1103556.38 898690.44 3524742.75 1755458 1317726.5 6360424 2539513.75 2065895.12 2216732.5 2923744.25 3056527.25 3198085 4268717.5 5009329.5 6135730.5 6193748.5 7472893.5 4723242 12121908 24513160 2115269.25 5278087.5 11130299 PC(28:1) 58761.5 150556.08 337412.75 20311.92 43042.14 115040.29 PC(30:0) 54698988 13443837 13264763 95020184 23343210 23325170 104756248 38032932 38893968 56035468 35762308 30759312 100987144 66652288 55980580 125828440 90274536 81098472 52228432 130695784 239209600 36086124 82927736 159724784 PC(30:1) 3168209.25 1520724 1923862.5 5770770.5 2578074.75 3168382 9514340 3466262.25 4651496 4356734.5 5129685.5 6769146 8267070 8592437 11242943 14149523 12937851 18430292 8706142 21492294 46915788 2741506.25 6783230 15011819 PC(32:0) 95909688 18929846 23426376 176079536 38159476 47470640 175315200 53865164 65274288 121294104 50407060 33961920 210643760 94591976 70916872 224098928 110587232 99476232 89363648 201458512 220974640 81535912 177185872 188927728 PC(32:1) 192406800 51174560 89403624 382299424 92204248 167798224 456862688 134162520 230655984 245763008 125499616 139632240 441142272 220606080 229697472 476123488 283430560 351744416 159134384 393251232 620522048 135737424 347830304 571644480 PC(32:2) 3532729 1305886.12 2254216.25 6445333.5 2537183 4166825 10995652 4184613.75 5826154 6018110 5631946.5 7853431.5 11640699 9493104 13207093 21924512 15519848 21895312 10374852 25104558 51561936 3678092.25 8691184 17596010 PC(34:1) 676530880 169730672 275861248 1059154880 282558464 484016992 1047203840 355000864 560346112 728890368 395864608 369288736 1170847616 644020736 580743296 1236953984 761947328 679957888 614514624 979416256 1221677952 507945856 946523648 1200038144 PC(34:2) 67296696 15473589 27217250 130786872 28660400 56030036 165838832 51159588 97939880 93639136 58557076 64342852 199213296 109995752 120748696 257488336 152558064 168354640 98007784 214397872 383227424 48979148 118011464 215343664 PC(36:1) 96516072 15580047 26733094 195395968 30610546 53168052 228409520 48962496 72090664 98179192 31655030 26187902 191831808 58841184 55359764 219126608 74081040 76378152 54858636 119724584 188665584 66205396 144593040 225482064 PC(36:2) 265517376 44765668 104457368 440578912 102550536 200683904 442233472 130851416 245126768 322461856 146274768 152865504 579504832 287562880 284299648 549821632 320203232 360101888 218513216 365459872 556423744 141895600 284973152 388340992 PC(36:3) 13101483 2783662.75 5764769.5 28520254 6701306.5 13645324 28050456 10689093 19549438 18133046 10046289 8927633 40052388 21472552 21285718 39838156 24895434 28644258 19547794 46711300 68510200 11610257 26491312 37760524 PC(36:4) 4233843 1198684.62 3205337.25 8737149 2127866.75 6500431.5 27175890 12795123 20614482 4478445 2492733.25 2908528 9166876 4668597.5 5243625.5 31943584 22604330 26675858 5250467.5 11012257 19110200 4908615.5 12570675 21524926 PC(36:5) 1188822.38 2812213.25 4890789.5 787019 1918906.12 3384861 PC(38:0) 477101.97 92043.79 86406.25 1040429.06 200528.38 188011.73 1379869.38 314705.84 272537.5 312057.59 81989.15 53372.39 706201.5 159036.92 116956.35 896721.25 208380.69 153278.95 105218.32 225871.75 429252.59 187654.86 386837.03 773078.56 PC(38:1) 3533652.75 627426.44 979452.81 7826991.5 1351855.62 1951263 9518872 1957510 2858950 2584891.75 805474.69 703845 6206291.5 1654051.62 1436768.5 7905977.5 2337330 2192092.25 1645111.12 3668625.75 6639603.5 2566445.75 5393000.5 10368235 PC(38:2) 27561174 3977242.75 7851408 55152148 9184156 15883039 68773240 13403624 23826358 26420046 8448591 8035697.5 56304620 19253266 17769198 69017760 24844310 25897558 14715053 35088592 59489360 11772128 24959918 40084636 PC(38:3) 2711016 652091.38 1326599.12 6486522.5 1562384.38 3187211.25 7859832 2577936.25 5013315.5 3877041 1729586.62 1579785.62 7240658 4048973 3975842 8842871 5950842.5 5932478.5 3788275.25 9771433 14136523 3139470.25 6480705.5 10414093 PC(38:4) 2102479 558168.94 1607967.88 4103467.25 1265903.38 2405082 6308604 2456087 5098464 2372833.25 1385650.62 846397.69 4530149.5 2724229.75 2702252.75 6220630.5 2687509 4960412.5 4318662.5 7372873.5 9664353 2901303.25 5231247.5 8554771 PC(38:5) 4582460 1104008.12 3920544.75 11191432 2626281.75 8513095 16782436 5580420 16295721 5506204.5 2713628 3606798.75 12771212 6888140 8787196 17974198 14485145 16924438 6119690.5 13225952 22032410 4047288.75 10815027 19001908 PC(38:6) 1906764.38 554223.44 1560844.62 3311718 876909.5 3007076.75 5159332 2030174.5 6221371.5 1738598.5 1125720 1719089 3289360 1911083.88 2896975.25 5351196.5 3348626 4989860.5 2361617 5439013.5 8858131 2453157.25 5318806.5 9597373 PC(40:0) 793613.25 145837.3 140163.33 1663315.12 306241.38 250694.08 2104410.75 455727.66 365202.28 467441.72 115803.26 77016.69 917766 258224.45 161255.09 1282294 298151.41 200498.7 88111.98 209217 415260.41 229379.69 488228.59 1029177.81 PC(40:1) 1005097 185227.44 250799.3 2267729.75 427844.91 546166.06 2907034.25 785740.69 841357.56 743482.5 218625.81 200425.92 1541661.88 487174.28 431431.28 2314186.25 715619.5 657058.5 371567.25 801627.19 1622290.62 560474.94 1277141.12 2539836 PC(40:2) 2283319.75 485438.78 712709.94 4774114.5 1065930.12 1714032.38 5935055.5 1498685.88 2309922.25 2027914.88 775210.31 775446.5 4306190 1682906.12 1647151.62 6001488 2089436 2135162 1049953.12 2333950.25 4251302.5 1001244.81 2282580.75 3975154 PC(40:3) 420527.75 84811.62 184087.62 1061599.38 233621.81 419026.25 1403715.88 314230.66 622010.69 593838 271790.66 205107.58 1542167.12 564651.81 494035.09 1958055.12 743544.31 737302.69 452057.34 1054936.88 1790386.38 270563.47 622075.25 1043500.81 PC(40:4) 316292.12 150317.94 293592.03 952661.56 293202.78 718074.25 1240512.12 509148.28 1096972 467940.5 229806.7 320930.41 1244611 588073.81 663015.12 1600930.38 886965.31 998571.31 672682.62 1325760.88 2115741 622862.56 1378649.38 1962246.12 PC(40:5) 1010264.31 280172.72 821870 1967777.38 609450.56 1762511.38 2862696 970767.56 2791513.25 984087.81 596740.44 859601.5 1879307.88 1335788.12 1719722.88 2573301.25 1805484.62 2565552.75 1532208.62 3072447.25 4264668.5 1258252.12 2766474.25 4293259.5 PC(40:6) 1308216.12 330577.09 1044407.06 2302466.75 656056.5 2079339.38 2542841.75 1208680.88 3546584.25 1380427.38 749638.25 1090478.38 2313389.5 1528366.62 2014673.38 3023296 1958545.38 2946249.75 1992788.5 4906815.5 5257808 1586575.12 3263746 3750819.75 PC(40:7) 1627485.5 443082 1355666 3730246 795948.69 2534718.25 4971630 1522137 4549069.5 1844120.12 1359345.12 1883699.62 3696074.25 2340823.25 3834530 4453458.5 3763864.25 6910997.5 3155656 6361509.5 11010908 1728377 4222528.5 7768183.5 PC(42:0) 408802 81896.3 80193.39 868491.69 178099.67 164304.8 1065253.12 286010.03 213110.25 216764.98 55927.52 37300.2 472007.75 115563.47 80366.78 606147.31 143027.22 104678.34 38878.5 93841.18 192282.81 116538.88 254220.19 591240.44 PC(42:1) 1268574.5 188763.36 303424.5 2549311.25 442198.22 595373.81 3570834 866355.31 1179995.75 736336.75 206668.7 184465.69 1596122.88 453367.59 391348.25 2383748.75 757539.94 701445.31 265172.22 560309.81 1234662.62 554692.81 1249392.5 2649586.5 PC(42:2) 1120151.88 225102.77 366565.59 2389765.25 488369.53 782920.44 2977458 851427.19 1154294 906677.44 336039.19 339736.09 1886391.62 749556.19 738573 2445554 928243 1129066.38 296767.38 697116.06 1391251.62 388508.09 869259.69 1738483.5 PC(42:6) 161497.19 43671.2 136009.8 352574.34 126156.75 337674.22 361917.38 156442.33 528361.38 230271.25 110608.96 153138.89 417797.22 243070.05 327546.75 579335.81 355927.59 677596.06 363143.53 799767.81 1176442.38 297740.47 504776.59 788603.19 PC(44:0) 12494.83 38643.82 52919.84 60875.06 140088.94 307338.41 PC(44:1) 91412.38 202193.39 421768.75 247511.62 556561.69 1148097.88 PC(44:2) 381010.22 78734.55 135038.08 778475.31 199625.14 300579.16 1124739.5 388424.91 568166 238855.8 95869.85 100139.26 549703.06 221070.14 229479.14 841861.56 352006.66 346035.97 101074.88 213131.12 431988.91 154829.55 368053.66 826578.25 PC(46:1) 268097.03 59015.59 71543.34 560291.19 130766.46 135110.81 807380.06 229933.69 230019 141919.17 53187.79 39790.75 302647.09 107246.96 86811.16 474216.97 151016.86 133234.25 52441 114747.66 270708.69 125190.91 341157.97 633695.31 PC(46:2) 40525.24 104326.34 223194.23 93016.99 187628.05 421202.78 PC(48:1) 254332.89 64217.71 61280.49 570220.5 132370.61 129576.34 754799.25 222732.08 175320.95 195048.86 60792.12 41887.48 410537.22 126482.84 101391.52 590481.19 162626.61 132936.88 71219.53 134567.12 292823.41 114372.93 292511.84 629278.25 PC(48:2) 441519.97 101674.69 158340.39 942034.25 218261.92 315192.97 1282639.25 340295.22 404543.16 224711.95 87028.23 91119.77 465784.97 187244.94 193119.48 659091.25 250108.95 251455.5 62484 137104.36 304578.03 138239.08 302757.88 636241.69 PC(50:1) 114044.93 25026.98 23335.12 228598.42 64716.77 50492.89 351256 107607.13 89948.02 114461.43 32253.76 22316.51 245000.45 75787.34 44078.82 397477 89605.27 63734.61 27287.14 77302.12 151626.88 50877.89 108773.54 297702.66 PC(50:2) 641221.56 138179 196497.25 1485994.12 277244.16 375399.91 1790080.62 439264.16 587711.94 335830.12 119787.03 107935.38 715825.31 254622.77 238739.98 967175.31 327382.72 336893.5 109950.37 240252.12 441669.91 196160.08 464958.22 1004324.56 PC(52:2) 404753.84 80967.32 98485.09 829027.44 163250.44 214270.45 1172040.88 262283.72 297371.59 246114.05 79375.69 59097.31 548397.81 162283.36 120010.56 784244.25 229955.14 207374.17 49909.84 111912.66 238451.25 70726.4 168920.94 397046.72 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name 20220508_pos_KO_rep1_4ul 20220508_pos_KO_rep3_4ul 20220508_pos_KO_rep4_4ul 20220508_pos_KO_rep1_8ul 20220508_pos_KO_rep3_8ul 20220508_pos_KO_rep4_8ul 20220508_pos_KO_rep1_16ul 20220508_pos_KO_rep3_16ul 20220508_pos_KO_rep4_16ul 20220508_pos_WT_rep1_4ul 20220508_pos_WT_rep3_4ul 20220508_pos_WT_rep4_4ul 20220508_pos_WT_rep1_8ul 20220508_pos_WT_rep3_8ul 20220508_pos_WT_rep4_8ul 20220508_pos_WT_rep1_16ul 20220508_pos_WT_rep3_16ul 20220508_pos_WT_rep4_16ul 20220820_tufts_MAMfrac_pos_rep8_WT_4ul 20220820_tufts_MAMfrac_pos_rep8_WT_8ul 20220820_tufts_MAMfrac_pos_rep8_WT_16ul 20220820_tufts_MAMfrac_pos_rep8_KO_4ul 20220820_tufts_MAMfrac_pos_rep8_KO_8ul 20220820_tufts_MAMfrac_pos_rep8_KO_16ul CE(16:0) 393477.28 665367.94 831400.06 348325.88 682535.81 861567.31 CE(16:1) 136345.61 41118.15 63762.69 293875.78 93477.71 131314.58 403820.78 126857.69 195064.77 161412.42 204277.02 91830.87 314206.5 457296.84 211830.33 546837.75 653363.94 318897.94 569970.25 1120316 1320605.62 240656.38 552138.5 633715.81 CE(18:1) 1122427.88 277995.38 407523.25 2343360 537186.31 923008 2736671.25 1020955.31 1416456.62 1415202.38 1764921.62 721122.69 3122456.75 3817384 1566658.5 4645244.5 5438359 2484470.25 4377441.5 9380143 10427111 1862277 3462956 4282025 CE(18:2) 114390.26 46555.64 101402.35 219558.08 92136.09 217561.95 278984.69 200902.45 319655.84 134209.89 132407.83 92259.59 298390.38 266704.16 190203.58 457560.84 379760.16 344270.12 403314.38 825440.31 1120367 221845.08 483882.5 623251.94 CE(18:3) 32742.27 74933.92 108887.18 17484.45 44023 65501.01 CE(20:1) 150150.11 26917.25 45638.04 301027.31 75387.59 90472.53 430249.66 119282.84 165148.39 167495.59 206469.83 82763.68 409004.97 406291.12 161958.25 559523.56 664096.56 255502.3 571394.81 1148599.12 1355615.38 188426 418188.84 603845.94 CE(20:4) 75118.38 35327.39 79081.19 171704.81 79543.62 161234.77 234118.55 125568.84 242909.19 87317.73 73742.91 60353.36 171507.89 153562.91 136859.55 250766.19 188724.55 205068.45 304707.59 610637.56 728806.81 193759.7 449628 561514.94 CE(22:1) 66061.14 15016.21 19569.53 127899.77 27912.44 43302.75 177951.7 58142.12 70690.07 70434.45 73597.8 25069.7 154795.88 169725.62 60812 229698.56 272890.53 112701.65 177244.11 360992.91 531469 74212.82 153220.77 225223.05 CE(22:6) 46236.25 16976.67 43346.02 100292.84 35277.3 92699.35 116058.84 66175.14 123513.7 33900.41 46578.09 43564.16 87547.81 98710.81 70737.3 125324.38 140786.14 117022.96 166347.08 355456.59 463236.91 114771.65 198252.06 222941 CE(24:0) 33902.38 2962.68 6610.52 73104.82 12672.01 21690.99 113015.62 29537.86 35026.78 21335.8 16945.08 6650.99 47029.05 38544.33 16873.52 64737.59 69367.99 32070.75 46250.88 104216.9 142494.98 97270.77 194520.45 309664.16 CE(24:1) 127201.21 28793.72 38692.89 268233.47 67925.09 84748.35 399303.84 121726.95 144282.64 115341.84 133606.27 46203.77 250449.95 289163.16 119934.47 431811.09 479002.09 195986.38 251338.58 531498.5 764652.81 151140.14 327934.62 472000.09 CE(26:0) 29711.39 0 4694.91 73926.05 6947.05 10292.25 116793.76 11538.72 25205.96 13333.22 8749.88 1639.8 38509.44 31275.34 10920.96 59712.18 40239.25 11069.68 34535.33 81779.02 118062.79 93477.15 228875.8 347542 CE(26:1) 73101.42 15819.62 17102.23 152080.95 41856.99 43588.89 256381.17 80126.84 90577.21 63778.39 75450.24 32187.8 147298.02 157163.42 54484.58 233809.89 255386.12 98102.29 125013.81 237664 374220.62 90848.62 216734.52 292656.38 CE(28:0) 11853.31 27945.05 39832.64 26954.41 69256.15 115472.55 CE(28:1) 36556.16 10970.22 7074.67 90622.3 22131.38 26680.58 138675.05 56912.12 50320.77 36560.86 38248.9 15231.92 80364.73 85362.52 32341.2 135188.17 152803.27 52353.25 69444.82 128191.49 225878.94 54239.95 115279.49 192263.5 CE(30:1) 70578.44 17846.62 22954.75 147235.61 34361.89 36220.55 245335.39 74095.22 74879.38 63498.62 44232.88 21876.26 119864.88 126386.07 53628.55 232459.94 232366.89 88730.32 104988.69 213594.39 332181.5 79887.63 166419.7 273481.31 CE(32:1) 95780.54 25814.53 25060.73 211214.12 64026.32 51325.64 391022 113121.57 111242.02 100950.04 103000.55 30851.77 234925.31 206463.42 68912.2 415237.12 355110.78 140738.95 161641.55 337652.91 553359 101530.05 241949.95 383677.66 CE(34:1) 32204.44 9525.25 8689.65 75080.57 18244.03 18470.21 112034.34 39158.07 35835.45 53861.43 37398.52 13300.65 110173.69 81246.01 30240.67 190606.38 135510.11 56126.82 61862.67 142653.14 241443.81 39046.29 74541.41 122360.84 CE(34:5) 20006.42 42540.81 65449.62 3880.12 14146.8 21851.61 CE(36:6) 22177.22 45982.67 75271.66 2455.06 10320.58 13812.71 DG(28:0) 482498.09 910067.69 735612.94 605884.94 864915.25 1073684.12 DG(30:0) 5063128.5 7776742.5 8027193.5 6384642 10587717 11178700 DG(30:1) 676383.5 1222199.75 1063721.25 565731.06 1087821.88 872201.5 DG(32:0) 12548928 24775078 25533838 20330248 34064360 40849544 DG(32:1) 2188091.75 687561.19 1904331.88 4479184.5 1377022.12 3808427.25 5246642.5 2139083.5 5033192 3006870.25 1619398.62 1967710.88 6262438 3462679.25 3999429 8477867 4391049.5 5561639.5 6742404.5 13034281 14423421 7924642.5 14320089 13722200 DG(34:1) 6863018.5 2003137.5 5491191.5 13129296 4335501.5 10864925 15668496 6248578 13561043 11325084 5012041.5 5207517.5 23399394 9911226 10744501 26707664 11989457 14065493 21908086 43214252 55696972 27478280 46856700 56933664 DG(34:2) 934615.69 362780.53 828224 1934304.5 706020.81 1645200.62 2406239.25 1085303.12 2131407.25 1455586.12 1097308.12 1181755.38 2904470.25 2232179.5 2440421.25 3727167.25 2695128.25 3133192.75 4305926.5 6866269.5 8393925 2585705.25 4854396.5 5392342.5 DG(36:1) 2613232.75 953678.19 1240831.62 5709019.5 1782942.12 2543195 6648466 3307178.75 3299743.75 3285257.25 1764443.38 1002587.81 7537782 3706162.25 2112212 9851444 4466616 2712355.25 5348697.5 10330540 11871632 7314598.5 13455667 15497409 DG(36:2) 2171354 779101.06 1841063.88 4567528 1656297.88 3752590 5373810.5 2585393 4935869.5 3554878.75 2058209.5 2042459 7960550 4302747 4205974 9936092 5190292.5 5604196 8400188 16869054 19406402 6162110.5 11267275 11602715 DG(36:3) 443532.25 923942 1101821.38 351507.97 540127.12 726970.75 DG(38:1) 466599.91 969661.44 1350746.62 758041.19 1531411.12 1832795.62 DG(38:2) 346088.38 109189.59 229549.2 704165.25 283366.59 519973.5 976142.44 579461.81 787789.81 434859.62 219602.17 212882.36 1036513.94 494840.03 456232.22 1692089.38 853792.31 681174.81 1157933.25 2109090.25 2973598 892375.75 1755911.5 1930221.12 DG(38:4) 380784.25 315004.78 163828.89 798274.81 691475.81 343422.34 913234.25 1059989.5 432744.62 573642.94 674360.31 198118.56 1158459.62 1319617 414875.22 1512116.62 1692442.5 564041.06 594105.94 950612.31 1464347.38 364413.66 614831.44 824295.56 DG(40:1) 96541.1 38780.3 70976.55 218840.44 84079.37 144672.94 284649.72 136460.69 246225.81 87393.69 29172.29 35939.91 222558.19 68534.63 75735.26 308289.5 100170.31 133196.08 262585.22 517066.97 692164.94 520524.41 1096707.5 1424717.5 DG(40:2) 53645.38 22662.02 52711.19 121663.72 48812.43 99444.96 170151.25 90069.9 162847.16 58345.39 32777.48 42613.49 164370.03 86105.35 89703.72 230459.67 121964.06 127703.12 186218.17 357854.53 443954.34 170156.77 279785.53 395702 DG(42:0) 116337 243136.67 304550 590136.44 1235472.62 1431608.62 DG(42:1) 72367.01 18170.69 57647.73 160331.56 53535.34 101659.16 208657.05 92348.41 177694.94 57833.08 24220.3 22406.03 133185.08 47722.96 53940.59 193713.95 59668.06 87700.38 140498.44 298850.69 389027.75 334999.34 697000 934907.25 DG(42:2) 40498.48 16592.84 40885.46 89040.38 39138.33 84048.66 109679.75 66367.09 117824.19 42956.27 24570.24 25220.9 95057.12 45293.7 56879.14 132354.86 65459.98 90031.19 114828.62 229326 307765.97 117522.91 263250.38 311639.72 DG(44:0) 26219.09 5499.77 15020.06 53151.34 18683.35 37016.19 58253.04 27979.73 44130.58 9198.57 3153.11 4099.14 34157.66 4120.57 9160.06 43314.98 7708.03 14205.68 28619.49 62270.46 90080.94 156268.83 318295.38 388729.62 DG(44:1) 40540.84 14944.65 37812.58 80755.41 29773.16 68848.05 105529.82 48606.16 103672.73 21080.67 8904.31 10523.28 47354.29 21595.31 26804.48 72774.79 25874.76 39848.93 55001.05 124169.5 172159.98 168267.55 321683.12 434318.75 DG(44:2) 16734.79 9019.37 18921.78 36494.05 17405.13 37747.82 41623.02 22392.34 58982.18 16028.26 6034.38 11034.01 39050.83 17983.21 26050.52 51834.57 20515.28 34294.25 42279.52 86035.62 106739.38 62372.89 113667.97 141820.98 DG(46:0) 19897.36 48180.52 35688.82 69638.13 165988.02 211649.3 DG(46:1) 27946.02 11112.68 28799.73 62010.31 26620.39 62700.95 96391.34 47949.17 101973.66 30301.81 9916.68 11186.53 62279.85 18140.78 25664.58 82872.3 34053.93 47470.32 80396.73 158072.7 217717.95 163457.69 341488.91 436302.91 DG(46:2) 25787.37 52233.81 68860.8 35188.94 63675.22 86446.43 DG(48:1) 57849.78 10610.07 42199.72 136616.03 32081.62 94089.32 198127.58 81845.4 161860.08 55516.16 19406.74 14746.96 114539.98 40791.66 44836.82 208634 79127.3 53739.43 144588.66 324027.06 494957.97 268737.53 620121.5 783887.56 DG(48:2) 22714.2 12082.41 28344.97 58764.61 25449.95 56077.42 76918.5 44920.37 78681.52 19851.38 5646.05 15789.29 44557.98 27008.68 34523.31 68504.7 35749.41 51417.83 46124.31 91462.38 130474.66 53648.05 134434.64 179165.89 TG(44:0) 870094.5 1960920.38 2556882 1202911.62 2598826.25 3302041 TG(44:1) 225197.69 448167.88 597456.25 191486.86 423421.84 519304 TG(46:0) 3914738 8875525 12353201 6514408.5 14114059 18367940 TG(46:1) 2095269.38 4154957 5621685.5 1907502.88 4228018 5509303.5 TG(46:2) 239430.95 467329.88 661398.69 122481.96 262480.66 386483.34 TG(48:0) 7768224 17161314 23754010 14923711 32485246 42881188 TG(48:1) 2198247 520934.12 645602.94 4907496 1141063.5 1368276.88 6784262 1822679.62 2128652.25 2122405.75 2641401.25 1228614.5 4570746.5 5666422.5 2633846.25 7248502.5 7624950.5 4276011.5 11545164 23559368 31322944 12312203 25368602 32713718 TG(48:2) 604044.81 167374.56 144778.69 1159390.38 314866.78 312187.56 1703419.5 570666.38 488493.66 566746.5 1095770.88 351443.03 1253849.88 2372896 769645.31 1842658 3489878.75 1350214.12 2076349.38 4507632 6165585.5 1188851.12 2558893.25 3437146.25 TG(48:3) 118043.98 249915.17 371698.38 45209.48 96756.68 136267.19 TG(50:0) 5061910 12881029 15672595 13743723 30681166 38075780 TG(50:1) 5538036 1027114.31 1664328.62 12960768 2389855.75 3486635 16870136 4069440 5694784.5 6805906 5058100.5 2218363.75 13541584 9409521 4898355.5 19798976 15050227 8031034 24734998 53938748 63214364 29883926 60570012 81298976 TG(50:2) 3195306 695851.06 848428.56 7012858 1374183.88 1686589.62 10442159 2755359.5 2760125 3728228 4277933 1415420.12 7746810 10313219 3228213 12866688 16039319 5235428 11253336 21307390 31022794 6399499.5 13315613 19616182 TG(50:3) 276213.56 74408.81 64651.16 627325.69 159869.09 149017.98 984770 302323.88 245364.95 365247.53 551536.25 193027.67 748832.69 1326801.25 399605.53 1307827.62 2001499.5 710268.31 969207.56 2113236.25 3408391.75 381179.03 804450.94 1294244.12 TG(52:0) 2058419.88 4613330.5 6427624.5 4910565.5 11410749 14143371 TG(52:1) 3253634 527366.62 753848.94 7403302.5 1165015.12 1791086.12 10474747 2146812.25 3024923.75 3190484 1873531 881361 7611658.5 4254057.5 1996588.88 11280200 6554056.5 3456546.25 12992328 25835554 37213260 18102042 39940896 49939700 TG(52:2) 7334873.5 1326879.5 1831778.5 16695075 3161975.75 4208848.5 23241490 5733668.5 6883018 9246017 7933054 2556794.25 19935690 17110152 5440480 30769104 25875088 9395561 22672142 50344716 65710848 14985788 30887698 44088960 TG(52:3) 4598078.5 10132304 14903953 1660569.5 3757998.25 5551442.5 TG(54:1) 718118 121020.04 177461.31 1507464.5 268908.62 403369 2476023.75 526905.31 738784.69 557867.25 285201.59 144734.08 1216263.75 667131.56 351995.59 2181105.25 1046871.69 588171 2541516 5600326 8426900 4019095.25 9590521 13688653 TG(54:2) 2299871.75 409944 579276.19 5574249 920717 1209302 8608582 1739677.88 2230986.5 2471263 1898117.12 634843.44 6016725.5 4418445 1464882.38 9538048 7542672.5 2764189.25 7037408 16158312 22000982 5742496 11739992 16380851 TG(54:3) 3040927 540373.56 625072.5 6521125.5 1230584.62 1312059.38 9496674 2121219 2341972 3860508.75 2872061.75 840219.69 9009803 6778334 1837045.5 13871009 10281197 3513611.25 8665736 18254266 25907806 2982738 6257451.5 9338155 TG(54:4) 547626.62 1179883.75 1912884.62 224862.69 420482.03 685863.06 TG(56:0) 284119.66 643498.12 871913.75 906218.44 2237552 3300322 TG(56:1) 245223.42 48974.59 75125.54 496944.16 101504.31 153777.69 829471.31 222962.56 275891.66 177212.31 95203.05 61284.41 377278.34 213426.69 130736.12 637303.44 384255.41 251401.86 686328.06 1615603.38 2543874.25 1148204.62 2837407.25 4299608.5 TG(56:2) 473168.41 86655.18 122141.09 994384.94 183272.36 264181.38 1759105 342237.5 483603.41 396726.03 298002.34 120590.5 883142.5 733983.06 278331.16 1598909.88 1233555.5 472605.5 1270072.12 2674983.25 4505829 972219.19 2263859.25 3625528.75 TG(56:3) 606022.06 105318.09 125467.46 1455229.88 237905.98 265329.59 2298740.25 439546.28 523591.47 715901.31 489696.41 142139.25 1696298.62 1215515.5 349344.94 2768147.25 2062523.62 669684.5 1889675.12 4171715.75 5990839.5 677676.19 1459547.62 2192441.25 TG(56:4) 66836.77 11257.57 16000.36 138687.23 33731.54 35446.17 253794.08 62304.16 68459.88 73840.05 71165.78 22253.33 182222.33 152182.48 45678.02 322847.41 298095.47 92741.31 203169.83 427602.91 740316.25 75029.41 191176.62 314329.47 TG(58:0) 195201.81 423981.34 618583.69 668342.56 1619244.38 2601084 TG(58:1) 236297.38 44136.02 67249.6 511161.22 90213.98 132822.95 852999.81 187760.83 260532.3 148278.88 85305.38 48112.07 336614.97 203460.05 102137.94 575708.44 333810.75 206595.38 526109.69 1190678.12 1815148.62 1047162.81 2324013.75 4031763.25 TG(58:2) 261827.86 53861.5 70099.59 524765.75 121110.66 168619.55 947353.69 218391.94 302446.91 200483.27 181869.19 69070.3 442080.53 373186.5 144570.61 785171.06 665743.5 316729.59 633003.5 1275340 2332203 509534 1256137.88 1994136 TG(58:3) 161325.14 37509.08 39675.2 346801.81 69307.56 77732.41 577721.44 119275.15 161949.27 177706.58 138972.08 49292.82 413612.28 335736.88 106718.29 655758.94 586475.81 192844.23 503221.84 1036508 1633732.62 188353.33 427460.12 607385.38 TG(60:0) 81380.09 170121 256662.31 269348.59 653175.19 1051693.12 TG(60:1) 135905.19 29948.41 39433.52 314171 64086.89 94486.21 528463.75 126690.54 176207.27 84732.41 55910.94 24515.53 166708.05 114428.81 61504.5 335437.75 192440.12 110945.27 302967.12 647198.31 1023469.31 565560.81 1336602.38 2215311.75 TG(60:2) 183441.25 40371.6 46230.19 437726 77364.75 106767.72 692228.5 155291.62 211041.62 121185.22 115478.72 43773.41 289586.38 242664.48 94393.18 509502.75 431147.41 195665.33 364415.38 841812.94 1339360.88 385768.97 816524.5 1393514.75 TG(60:3) 104263.62 25999.84 23400.63 219583.3 45987.89 64065.27 387805.91 100440.31 112642.85 109779.34 87459.34 39223.88 229297.02 214713.3 74958.41 383828.5 385953.34 145557.88 273438.66 576497.44 890260.19 109545.48 262106.64 426835.84 TG(62:0) 26911.65 55034.03 91833.78 94820.46 212607.8 364512.09 TG(62:1) 81576.24 12084.27 21959.82 150559.67 34438.44 60536.89 283708.97 81737.9 102672.75 44802.39 27171.1 21453.4 97152.12 52823.51 27077.69 161397.95 85107.07 63224.64 181947.25 364607.22 676355.69 302984.72 730975.75 1266991.38 TG(62:2) 104740.69 20086.28 37448.79 237153.75 52815.11 67476.4 412337.91 103645.47 132267.81 66454.41 56298.89 24028.59 147547.03 133841.84 53639.47 279488.53 239996.56 110754.62 192853.25 418117.09 745332.25 201931.02 470370.41 780490 TG(62:3) 55465.47 13011.34 16338.71 130168.71 21207.63 33597.36 193301.19 49611.04 67156.68 39900.29 37078.02 16294.63 100155.99 93219.48 32843.22 169203.7 168469.33 64770.97 101244.75 255147.17 425700.5 45090.08 121981.13 204047.3 TG(64:1) 67086.86 12833.9 25313.06 133233.62 32357.56 41729.45 265018.16 73899.86 97114.73 52717.1 25817.24 16691.52 118625.21 57364.53 35065.94 211953.88 97116.91 65194.14 172086.58 395835.03 664583.81 282951.97 605901.81 1096489.5 TG(64:2) 91396.65 23210.51 34752.47 221665.67 64637.47 67299.98 368447.5 112257.51 142338.48 77240.2 63218.39 30597.26 143238.22 137627.58 64898.91 272975.5 240975.3 107262.41 215102.27 439663.5 764739.06 183092.62 455960.59 734519.5 TG(64:3) 42638.59 12260.92 13029.76 90994.97 24637.37 25498.75 143594.36 48717.61 52194.44 29092.4 34661.96 11300.25 60662.68 67206.3 19613.79 110983.4 116960.02 54686.55 69995.71 150716.36 286656.56 35873.55 78302.02 129876.79 TG(66:1) 41712.78 5004.47 12476.72 76563.97 19641.15 26531.76 149752.39 45544.19 52048.19 39226.86 12145.75 9489.74 76007.14 31589.6 18264.38 158796.31 56959.56 32225.23 109058.91 237026.75 470130.84 140023.39 335607.84 561710.56 TG(66:2) 104697.62 32528.43 27420.26 236821.33 57515.34 72783.49 443641.09 131230.81 146023 104335.04 63023.29 30917.58 232575.17 157521.45 65852.27 403799.66 278939.81 133246.56 256438.83 574397.81 986298.56 177960.75 453389.53 815762.69 TG(68:2) 47098.12 13364.54 18578.52 117687.54 28098.89 35021.01 225990.52 61226.88 62123.05 73772.78 36591.18 13696.6 152953.64 77239.48 31355.29 265826.72 139022.73 69990.6 144276.19 322184.38 636191.81 90896.12 210875.05 315386.41 TG(68:3) 72650.88 14206.61 12201.18 135359.64 32836.73 38741.91 226095.23 67617.27 78771.26 63438.78 41076.11 17469.74 138990.73 88674.29 35652.56 261422.86 185228.2 70019.87 113217.69 247258.14 445303.41 42993.41 107142.9 174280.08 TG(70:2) 12124.94 2087.61 2428.65 29892.07 6956.48 11161.23 54328.86 16729.29 20369.45 13562.07 7652.32 2230.86 35135.56 19727.39 6012.46 76478.41 39589.69 19543.69 37952.29 95073.87 175859.52 25250.66 49478.47 91523.46 TG(70:3) 17387.03 5488.64 5989.12 62422.97 13593.63 15732.84 105534.16 33698.47 25339.24 41569.64 24356.99 6646.4 78697.41 38557.34 15052.06 150673.67 89079.97 36592.02 63927.32 139347.41 252086.55 17641.87 45058.79 79398.12 LPC(16:0) 31066630 6414895.5 12408235 36105436 8485069 15639973 49217136 14342797 25393926 33088742 9123111 9652891 43041012 12196816 14114732 57514580 17301450 23089342 10994053 14869195 19061288 17464508 23448128 29598890 LPC(18:0) 9002597 1268337.62 1883053.88 14740948 2362716.25 3333449.25 17477002 3599220 4531444.5 7348322.5 1474784.88 1402194 11110522 2512916.5 2525628.5 14549769 3363510.75 3776855.25 2096804 3350368.25 5101995 4387898.5 7295880 10072265 LPC(18:1) 13407899 2625422 4975345 17858376 5243918 8397302 23192766 8922376 13758745 15567593 6131526.5 4713162.5 20872598 10555113 7618442.5 28618278 16813798 13444973 5055298.5 7142185.5 11770155 4087162 5915106 9882797 LPC(20:1) 3652544 635669.56 890185.5 3920423 895707.69 1096154.12 4976750.5 1489616.88 1749868.38 2926676.75 637230.25 751800.81 4152558 862060.75 752762.56 5289306 1419251.62 1478841.88 561229.94 910313.56 1516909.12 553739.12 922222.5 1518409.88 LPC(22:0) 22325.41 49384 102665.81 59213.63 136437.58 244382.42 LPC(24:0) 575263.75 59622.76 57282.41 831167 82674.18 86934.46 1538244 132191.8 131835.39 290073.53 47181.53 37276.94 383021.25 71776.81 64283.59 770453.44 116535.85 108491.13 58147.31 135272.2 332892.78 184252.5 423271.09 938888 LPC(24:1) 473428.47 60124.07 69474.49 636610.75 101688.81 87411.21 880504.69 118871.31 130074.63 307654.72 54666.54 55366.72 428513.12 80666.76 65203.83 579738 113217.23 101340.63 41479.86 122947.28 230538.7 80803.23 131910.72 365518.25 PC(28:0) 2449624.75 1103556.38 898690.44 3524742.75 1755458 1317726.5 6360424 2539513.75 2065895.12 2216732.5 2923744.25 3056527.25 3198085 4268717.5 5009329.5 6135730.5 6193748.5 7472893.5 4723242 12121908 24513160 2115269.25 5278087.5 11130299 PC(28:1) 58761.5 150556.08 337412.75 20311.92 43042.14 115040.29 PC(30:0) 54698988 13443837 13264763 95020184 23343210 23325170 104756248 38032932 38893968 56035468 35762308 30759312 100987144 66652288 55980580 125828440 90274536 81098472 52228432 130695784 239209600 36086124 82927736 159724784 PC(30:1) 3168209.25 1520724 1923862.5 5770770.5 2578074.75 3168382 9514340 3466262.25 4651496 4356734.5 5129685.5 6769146 8267070 8592437 11242943 14149523 12937851 18430292 8706142 21492294 46915788 2741506.25 6783230 15011819 PC(32:0) 95909688 18929846 23426376 176079536 38159476 47470640 175315200 53865164 65274288 121294104 50407060 33961920 210643760 94591976 70916872 224098928 110587232 99476232 89363648 201458512 220974640 81535912 177185872 188927728 PC(32:1) 192406800 51174560 89403624 382299424 92204248 167798224 456862688 134162520 230655984 245763008 125499616 139632240 441142272 220606080 229697472 476123488 283430560 351744416 159134384 393251232 620522048 135737424 347830304 571644480 PC(32:2) 3532729 1305886.12 2254216.25 6445333.5 2537183 4166825 10995652 4184613.75 5826154 6018110 5631946.5 7853431.5 11640699 9493104 13207093 21924512 15519848 21895312 10374852 25104558 51561936 3678092.25 8691184 17596010 PC(34:1) 676530880 169730672 275861248 1059154880 282558464 484016992 1047203840 355000864 560346112 728890368 395864608 369288736 1170847616 644020736 580743296 1236953984 761947328 679957888 614514624 979416256 1221677952 507945856 946523648 1200038144 PC(34:2) 67296696 15473589 27217250 130786872 28660400 56030036 165838832 51159588 97939880 93639136 58557076 64342852 199213296 109995752 120748696 257488336 152558064 168354640 98007784 214397872 383227424 48979148 118011464 215343664 PC(36:1) 96516072 15580047 26733094 195395968 30610546 53168052 228409520 48962496 72090664 98179192 31655030 26187902 191831808 58841184 55359764 219126608 74081040 76378152 54858636 119724584 188665584 66205396 144593040 225482064 PC(36:2) 265517376 44765668 104457368 440578912 102550536 200683904 442233472 130851416 245126768 322461856 146274768 152865504 579504832 287562880 284299648 549821632 320203232 360101888 218513216 365459872 556423744 141895600 284973152 388340992 PC(36:3) 13101483 2783662.75 5764769.5 28520254 6701306.5 13645324 28050456 10689093 19549438 18133046 10046289 8927633 40052388 21472552 21285718 39838156 24895434 28644258 19547794 46711300 68510200 11610257 26491312 37760524 PC(36:4) 4233843 1198684.62 3205337.25 8737149 2127866.75 6500431.5 27175890 12795123 20614482 4478445 2492733.25 2908528 9166876 4668597.5 5243625.5 31943584 22604330 26675858 5250467.5 11012257 19110200 4908615.5 12570675 21524926 PC(36:5) 1188822.38 2812213.25 4890789.5 787019 1918906.12 3384861 PC(38:0) 477101.97 92043.79 86406.25 1040429.06 200528.38 188011.73 1379869.38 314705.84 272537.5 312057.59 81989.15 53372.39 706201.5 159036.92 116956.35 896721.25 208380.69 153278.95 105218.32 225871.75 429252.59 187654.86 386837.03 773078.56 PC(38:1) 3533652.75 627426.44 979452.81 7826991.5 1351855.62 1951263 9518872 1957510 2858950 2584891.75 805474.69 703845 6206291.5 1654051.62 1436768.5 7905977.5 2337330 2192092.25 1645111.12 3668625.75 6639603.5 2566445.75 5393000.5 10368235 PC(38:2) 27561174 3977242.75 7851408 55152148 9184156 15883039 68773240 13403624 23826358 26420046 8448591 8035697.5 56304620 19253266 17769198 69017760 24844310 25897558 14715053 35088592 59489360 11772128 24959918 40084636 PC(38:3) 2711016 652091.38 1326599.12 6486522.5 1562384.38 3187211.25 7859832 2577936.25 5013315.5 3877041 1729586.62 1579785.62 7240658 4048973 3975842 8842871 5950842.5 5932478.5 3788275.25 9771433 14136523 3139470.25 6480705.5 10414093 PC(38:4) 2102479 558168.94 1607967.88 4103467.25 1265903.38 2405082 6308604 2456087 5098464 2372833.25 1385650.62 846397.69 4530149.5 2724229.75 2702252.75 6220630.5 2687509 4960412.5 4318662.5 7372873.5 9664353 2901303.25 5231247.5 8554771 PC(38:5) 4582460 1104008.12 3920544.75 11191432 2626281.75 8513095 16782436 5580420 16295721 5506204.5 2713628 3606798.75 12771212 6888140 8787196 17974198 14485145 16924438 6119690.5 13225952 22032410 4047288.75 10815027 19001908 PC(38:6) 1906764.38 554223.44 1560844.62 3311718 876909.5 3007076.75 5159332 2030174.5 6221371.5 1738598.5 1125720 1719089 3289360 1911083.88 2896975.25 5351196.5 3348626 4989860.5 2361617 5439013.5 8858131 2453157.25 5318806.5 9597373 PC(40:0) 793613.25 145837.3 140163.33 1663315.12 306241.38 250694.08 2104410.75 455727.66 365202.28 467441.72 115803.26 77016.69 917766 258224.45 161255.09 1282294 298151.41 200498.7 88111.98 209217 415260.41 229379.69 488228.59 1029177.81 PC(40:1) 1005097 185227.44 250799.3 2267729.75 427844.91 546166.06 2907034.25 785740.69 841357.56 743482.5 218625.81 200425.92 1541661.88 487174.28 431431.28 2314186.25 715619.5 657058.5 371567.25 801627.19 1622290.62 560474.94 1277141.12 2539836 PC(40:2) 2283319.75 485438.78 712709.94 4774114.5 1065930.12 1714032.38 5935055.5 1498685.88 2309922.25 2027914.88 775210.31 775446.5 4306190 1682906.12 1647151.62 6001488 2089436 2135162 1049953.12 2333950.25 4251302.5 1001244.81 2282580.75 3975154 PC(40:3) 420527.75 84811.62 184087.62 1061599.38 233621.81 419026.25 1403715.88 314230.66 622010.69 593838 271790.66 205107.58 1542167.12 564651.81 494035.09 1958055.12 743544.31 737302.69 452057.34 1054936.88 1790386.38 270563.47 622075.25 1043500.81 PC(40:4) 316292.12 150317.94 293592.03 952661.56 293202.78 718074.25 1240512.12 509148.28 1096972 467940.5 229806.7 320930.41 1244611 588073.81 663015.12 1600930.38 886965.31 998571.31 672682.62 1325760.88 2115741 622862.56 1378649.38 1962246.12 PC(40:5) 1010264.31 280172.72 821870 1967777.38 609450.56 1762511.38 2862696 970767.56 2791513.25 984087.81 596740.44 859601.5 1879307.88 1335788.12 1719722.88 2573301.25 1805484.62 2565552.75 1532208.62 3072447.25 4264668.5 1258252.12 2766474.25 4293259.5 PC(40:6) 1308216.12 330577.09 1044407.06 2302466.75 656056.5 2079339.38 2542841.75 1208680.88 3546584.25 1380427.38 749638.25 1090478.38 2313389.5 1528366.62 2014673.38 3023296 1958545.38 2946249.75 1992788.5 4906815.5 5257808 1586575.12 3263746 3750819.75 PC(40:7) 1627485.5 443082 1355666 3730246 795948.69 2534718.25 4971630 1522137 4549069.5 1844120.12 1359345.12 1883699.62 3696074.25 2340823.25 3834530 4453458.5 3763864.25 6910997.5 3155656 6361509.5 11010908 1728377 4222528.5 7768183.5 PC(42:0) 408802 81896.3 80193.39 868491.69 178099.67 164304.8 1065253.12 286010.03 213110.25 216764.98 55927.52 37300.2 472007.75 115563.47 80366.78 606147.31 143027.22 104678.34 38878.5 93841.18 192282.81 116538.88 254220.19 591240.44 PC(42:1) 1268574.5 188763.36 303424.5 2549311.25 442198.22 595373.81 3570834 866355.31 1179995.75 736336.75 206668.7 184465.69 1596122.88 453367.59 391348.25 2383748.75 757539.94 701445.31 265172.22 560309.81 1234662.62 554692.81 1249392.5 2649586.5 PC(42:2) 1120151.88 225102.77 366565.59 2389765.25 488369.53 782920.44 2977458 851427.19 1154294 906677.44 336039.19 339736.09 1886391.62 749556.19 738573 2445554 928243 1129066.38 296767.38 697116.06 1391251.62 388508.09 869259.69 1738483.5 PC(42:6) 161497.19 43671.2 136009.8 352574.34 126156.75 337674.22 361917.38 156442.33 528361.38 230271.25 110608.96 153138.89 417797.22 243070.05 327546.75 579335.81 355927.59 677596.06 363143.53 799767.81 1176442.38 297740.47 504776.59 788603.19 PC(44:0) 12494.83 38643.82 52919.84 60875.06 140088.94 307338.41 PC(44:1) 91412.38 202193.39 421768.75 247511.62 556561.69 1148097.88 PC(44:2) 381010.22 78734.55 135038.08 778475.31 199625.14 300579.16 1124739.5 388424.91 568166 238855.8 95869.85 100139.26 549703.06 221070.14 229479.14 841861.56 352006.66 346035.97 101074.88 213131.12 431988.91 154829.55 368053.66 826578.25 PC(46:1) 268097.03 59015.59 71543.34 560291.19 130766.46 135110.81 807380.06 229933.69 230019 141919.17 53187.79 39790.75 302647.09 107246.96 86811.16 474216.97 151016.86 133234.25 52441 114747.66 270708.69 125190.91 341157.97 633695.31 PC(46:2) 40525.24 104326.34 223194.23 93016.99 187628.05 421202.78 PC(48:1) 254332.89 64217.71 61280.49 570220.5 132370.61 129576.34 754799.25 222732.08 175320.95 195048.86 60792.12 41887.48 410537.22 126482.84 101391.52 590481.19 162626.61 132936.88 71219.53 134567.12 292823.41 114372.93 292511.84 629278.25 PC(48:2) 441519.97 101674.69 158340.39 942034.25 218261.92 315192.97 1282639.25 340295.22 404543.16 224711.95 87028.23 91119.77 465784.97 187244.94 193119.48 659091.25 250108.95 251455.5 62484 137104.36 304578.03 138239.08 302757.88 636241.69 PC(50:1) 114044.93 25026.98 23335.12 228598.42 64716.77 50492.89 351256 107607.13 89948.02 114461.43 32253.76 22316.51 245000.45 75787.34 44078.82 397477 89605.27 63734.61 27287.14 77302.12 151626.88 50877.89 108773.54 297702.66 PC(50:2) 641221.56 138179 196497.25 1485994.12 277244.16 375399.91 1790080.62 439264.16 587711.94 335830.12 119787.03 107935.38 715825.31 254622.77 238739.98 967175.31 327382.72 336893.5 109950.37 240252.12 441669.91 196160.08 464958.22 1004324.56 PC(52:2) 404753.84 80967.32 98485.09 829027.44 163250.44 214270.45 1172040.88 262283.72 297371.59 246114.05 79375.69 59097.31 548397.81 162283.36 120010.56 784244.25 229955.14 207374.17 49909.84 111912.66 238451.25 70726.4 168920.94 397046.72 METABOLITES_END #END