#METABOLOMICS WORKBENCH WangLab_20230227_072523 DATATRACK_ID:3766 STUDY_ID:ST002500 ANALYSIS_ID:AN004109 PROJECT_ID:PR001614 VERSION 1 CREATED_ON March 1, 2023, 5:39 pm #PROJECT PR:PROJECT_TITLE Study on human plasma metabolomics PR:PROJECT_TYPE MS quantitative analysis PR:PROJECT_SUMMARY Multicenter quantitative metabolomics study of samples from human sources PR:INSTITUTE Soochow University PR:LAST_NAME Wang PR:FIRST_NAME Chang PR:ADDRESS No. 199, Renai Road, Suzhou Industrial Park PR:EMAIL wangchang@suda.edu.cn PR:PHONE +86-512-65880067 #STUDY ST:STUDY_TITLE Plasma metabolomic signatures from patients following high-dose total body ST:STUDY_TITLE irradiation ST:STUDY_SUMMARY Plasma metabolic characteristics were investigated from patients of ST:STUDY_SUMMARY hematopoietic stem cell transplantation following high-dose TBI pretreatment ST:STUDY_SUMMARY utilizing gas chromatography-mass spectrometry (GC-MS) and liquid ST:STUDY_SUMMARY chromatography-mass spectrometry (LC-MS). ST:INSTITUTE Soochow University ST:LAST_NAME Wang ST:FIRST_NAME Chang ST:ADDRESS No. 199, Renai Road, Suzhou Industrial Park ST:EMAIL wangchang@suda.edu.cn ST:PHONE +8651265880067 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:GENDER #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS TBI-50 neg-Pre-TBI-1 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A01.raw SUBJECT_SAMPLE_FACTORS TBI-58 neg-Pre-TBI-2 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A02.raw SUBJECT_SAMPLE_FACTORS TBI-41 neg-Pre-TBI-5 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A03.raw SUBJECT_SAMPLE_FACTORS TBI-55 neg-Pre-TBI-6 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A04.raw SUBJECT_SAMPLE_FACTORS TBI-67 neg-Pre-TBI-7 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A05.raw SUBJECT_SAMPLE_FACTORS TBI-49 neg-Pre-TBI-8 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A06.raw SUBJECT_SAMPLE_FACTORS TBI-52 neg-Pre-TBI-9 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A07.raw SUBJECT_SAMPLE_FACTORS TBI-48 neg-Pre-TBI-10 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A08.raw SUBJECT_SAMPLE_FACTORS TBI-70 neg-Pre-TBI-11 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A09.raw SUBJECT_SAMPLE_FACTORS TBI-64 neg-Pre-TBI-12 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A10.raw SUBJECT_SAMPLE_FACTORS TBI-71 neg-Pre-TBI-13 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A11.raw SUBJECT_SAMPLE_FACTORS TBI-53 neg-Pre-TBI-14 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A12.raw SUBJECT_SAMPLE_FACTORS TBI-76 neg-Pre-TBI-15 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A13.raw SUBJECT_SAMPLE_FACTORS TBI-47 neg-Pre-TBI-16 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A14.raw SUBJECT_SAMPLE_FACTORS TBI-59 neg-Pre-TBI-17 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A15.raw SUBJECT_SAMPLE_FACTORS TBI-72 neg-Pre-TBI-18 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A16.raw SUBJECT_SAMPLE_FACTORS TBI-57 neg-Pre-TBI-19 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A18.raw SUBJECT_SAMPLE_FACTORS TBI-45 neg-Pre-TBI-20 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A19.raw SUBJECT_SAMPLE_FACTORS TBI-43 neg-Pre-TBI-21 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A20.raw SUBJECT_SAMPLE_FACTORS TBI-68 neg-Pre-TBI-22 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A21.raw SUBJECT_SAMPLE_FACTORS TBI-73 neg-Pre-TBI-23 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A22.raw SUBJECT_SAMPLE_FACTORS TBI-78 neg-Pre-TBI-24 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A23.raw SUBJECT_SAMPLE_FACTORS TBI-77 neg-Pre-TBI-25 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A24.raw SUBJECT_SAMPLE_FACTORS TBI-61 neg-Pre-TBI-26 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A25.raw SUBJECT_SAMPLE_FACTORS TBI-66 neg-Pre-TBI-27 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A27.raw SUBJECT_SAMPLE_FACTORS TBI-75 neg-Pre-TBI-28 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A28.raw SUBJECT_SAMPLE_FACTORS TBI-62 neg-Pre-TBI-29 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A29.raw SUBJECT_SAMPLE_FACTORS TBI-74 neg-Pre-TBI-30 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A30.raw SUBJECT_SAMPLE_FACTORS TBI-56 neg-Pre-TBI-31 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A31.raw SUBJECT_SAMPLE_FACTORS TBI-60 neg-Pre-TBI-32 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A32.raw SUBJECT_SAMPLE_FACTORS TBI-69 neg-Pre-TBI-33 Treatment:Control Sex=Female; Batch=1a; RAW_FILE_NAME=20180721A33.raw SUBJECT_SAMPLE_FACTORS TBI-46 neg-Pre-TBI-34 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A35.raw SUBJECT_SAMPLE_FACTORS TBI-79 neg-Pre-TBI-35 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A36.raw SUBJECT_SAMPLE_FACTORS TBI-65 neg-Pre-TBI-36 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A37.raw SUBJECT_SAMPLE_FACTORS TBI-63 neg-Pre-TBI-37 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A38.raw SUBJECT_SAMPLE_FACTORS TBI-42 neg-Pre-TBI-38 Treatment:Control Sex=Male; Batch=1a; RAW_FILE_NAME=20180721A39.raw SUBJECT_SAMPLE_FACTORS TBI-1 neg-TBI-1 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072101.raw SUBJECT_SAMPLE_FACTORS TBI-2 neg-TBI-2 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072102.raw SUBJECT_SAMPLE_FACTORS TBI-3 neg-TBI-5 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072103.raw SUBJECT_SAMPLE_FACTORS TBI-4 neg-TBI-6 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072104.raw SUBJECT_SAMPLE_FACTORS TBI-5 neg-TBI-7 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072105.raw SUBJECT_SAMPLE_FACTORS TBI-6 neg-TBI-8 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072106.raw SUBJECT_SAMPLE_FACTORS TBI-7 neg-TBI-9 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072107.raw SUBJECT_SAMPLE_FACTORS TBI-8 neg-TBI-10 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072108.raw SUBJECT_SAMPLE_FACTORS TBI-9 neg-TBI-11 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072109.raw SUBJECT_SAMPLE_FACTORS TBI-10 neg-TBI-12 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072110.raw SUBJECT_SAMPLE_FACTORS TBI-11 neg-TBI-13 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072111.raw SUBJECT_SAMPLE_FACTORS TBI-12 neg-TBI-14 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072112.raw SUBJECT_SAMPLE_FACTORS TBI-13 neg-TBI-15 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072113.raw SUBJECT_SAMPLE_FACTORS TBI-14 neg-TBI-16 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072114.raw SUBJECT_SAMPLE_FACTORS TBI-15 neg-TBI-17 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072115.raw SUBJECT_SAMPLE_FACTORS TBI-16 neg-TBI-18 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072116.raw SUBJECT_SAMPLE_FACTORS TBI-18 neg-TBI-19 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072118.raw SUBJECT_SAMPLE_FACTORS TBI-19 neg-TBI-20 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072119.raw SUBJECT_SAMPLE_FACTORS TBI-20 neg-TBI-21 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072120.raw SUBJECT_SAMPLE_FACTORS TBI-21 neg-TBI-22 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072121.raw SUBJECT_SAMPLE_FACTORS TBI-22 neg-TBI-23 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072122.raw SUBJECT_SAMPLE_FACTORS TBI-23 neg-TBI-24 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072123.raw SUBJECT_SAMPLE_FACTORS TBI-24 neg-TBI-25 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072124.raw SUBJECT_SAMPLE_FACTORS TBI-25 neg-TBI-26 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072125.raw SUBJECT_SAMPLE_FACTORS TBI-27 neg-TBI-27 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072127.raw SUBJECT_SAMPLE_FACTORS TBI-28 neg-TBI-28 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072128.raw SUBJECT_SAMPLE_FACTORS TBI-29 neg-TBI-29 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072129.raw SUBJECT_SAMPLE_FACTORS TBI-30 neg-TBI-30 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072130.raw SUBJECT_SAMPLE_FACTORS TBI-31 neg-TBI-31 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072131.raw SUBJECT_SAMPLE_FACTORS TBI-32 neg-TBI-32 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072132.raw SUBJECT_SAMPLE_FACTORS TBI-33 neg-TBI-33 Treatment:TBI Sex=Female; Batch=1a; RAW_FILE_NAME=2018072133.raw SUBJECT_SAMPLE_FACTORS TBI-35 neg-TBI-34 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072135.raw SUBJECT_SAMPLE_FACTORS TBI-36 neg-TBI-35 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072136.raw SUBJECT_SAMPLE_FACTORS TBI-37 neg-TBI-36 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072137.raw SUBJECT_SAMPLE_FACTORS TBI-38 neg-TBI-37 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072138.raw SUBJECT_SAMPLE_FACTORS TBI-39 neg-TBI-38 Treatment:TBI Sex=Male; Batch=1a; RAW_FILE_NAME=2018072139.raw SUBJECT_SAMPLE_FACTORS TBI-50 pos-Pre-TBI-1 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A01.raw SUBJECT_SAMPLE_FACTORS TBI-58 pos-Pre-TBI-2 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A02.raw SUBJECT_SAMPLE_FACTORS TBI-41 pos-Pre-TBI-5 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A03.raw SUBJECT_SAMPLE_FACTORS TBI-55 pos-Pre-TBI-6 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A04.raw SUBJECT_SAMPLE_FACTORS TBI-67 pos-Pre-TBI-7 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A05.raw SUBJECT_SAMPLE_FACTORS TBI-49 pos-Pre-TBI-8 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A06.raw SUBJECT_SAMPLE_FACTORS TBI-52 pos-Pre-TBI-9 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A07.raw SUBJECT_SAMPLE_FACTORS TBI-48 pos-Pre-TBI-10 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A08.raw SUBJECT_SAMPLE_FACTORS TBI-70 pos-Pre-TBI-11 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A09.raw SUBJECT_SAMPLE_FACTORS TBI-64 pos-Pre-TBI-12 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A10.raw SUBJECT_SAMPLE_FACTORS TBI-71 pos-Pre-TBI-13 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A11.raw SUBJECT_SAMPLE_FACTORS TBI-53 pos-Pre-TBI-14 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A12.raw SUBJECT_SAMPLE_FACTORS TBI-76 pos-Pre-TBI-15 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A13.raw SUBJECT_SAMPLE_FACTORS TBI-47 pos-Pre-TBI-16 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A14.raw SUBJECT_SAMPLE_FACTORS TBI-59 pos-Pre-TBI-17 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A15.raw SUBJECT_SAMPLE_FACTORS TBI-72 pos-Pre-TBI-18 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A16.raw SUBJECT_SAMPLE_FACTORS TBI-57 pos-Pre-TBI-19 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A18.raw SUBJECT_SAMPLE_FACTORS TBI-45 pos-Pre-TBI-20 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A19.raw SUBJECT_SAMPLE_FACTORS TBI-43 pos-Pre-TBI-21 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A20.raw SUBJECT_SAMPLE_FACTORS TBI-68 pos-Pre-TBI-22 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A21.raw SUBJECT_SAMPLE_FACTORS TBI-73 pos-Pre-TBI-23 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A22.raw SUBJECT_SAMPLE_FACTORS TBI-78 pos-Pre-TBI-24 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A23.raw SUBJECT_SAMPLE_FACTORS TBI-77 pos-Pre-TBI-25 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A24.raw SUBJECT_SAMPLE_FACTORS TBI-61 pos-Pre-TBI-26 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A25.raw SUBJECT_SAMPLE_FACTORS TBI-66 pos-Pre-TBI-27 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A27.raw SUBJECT_SAMPLE_FACTORS TBI-75 pos-Pre-TBI-28 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A28.raw SUBJECT_SAMPLE_FACTORS TBI-62 pos-Pre-TBI-29 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A29.raw SUBJECT_SAMPLE_FACTORS TBI-74 pos-Pre-TBI-30 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A30.raw SUBJECT_SAMPLE_FACTORS TBI-56 pos-Pre-TBI-31 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A31.raw SUBJECT_SAMPLE_FACTORS TBI-60 pos-Pre-TBI-32 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A32.raw SUBJECT_SAMPLE_FACTORS TBI-69 pos-Pre-TBI-33 Treatment:Control Sex=Female; Batch=1b; RAW_FILE_NAME=20180720A33.raw SUBJECT_SAMPLE_FACTORS TBI-46 pos-Pre-TBI-34 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A35.raw SUBJECT_SAMPLE_FACTORS TBI-79 pos-Pre-TBI-35 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A36.raw SUBJECT_SAMPLE_FACTORS TBI-65 pos-Pre-TBI-36 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A37.raw SUBJECT_SAMPLE_FACTORS TBI-63 pos-Pre-TBI-37 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A38.raw SUBJECT_SAMPLE_FACTORS TBI-42 pos-Pre-TBI-38 Treatment:Control Sex=Male; Batch=1b; RAW_FILE_NAME=20180720A39.raw SUBJECT_SAMPLE_FACTORS TBI-1 pos-TBI-1 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071901.raw SUBJECT_SAMPLE_FACTORS TBI-2 pos-TBI-2 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071902.raw SUBJECT_SAMPLE_FACTORS TBI-3 pos-TBI-5 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071903.raw SUBJECT_SAMPLE_FACTORS TBI-4 pos-TBI-6 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071904.raw SUBJECT_SAMPLE_FACTORS TBI-5 pos-TBI-7 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071905.raw SUBJECT_SAMPLE_FACTORS TBI-6 pos-TBI-8 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071906.raw SUBJECT_SAMPLE_FACTORS TBI-7 pos-TBI-9 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071907.raw SUBJECT_SAMPLE_FACTORS TBI-8 pos-TBI-10 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071908.raw SUBJECT_SAMPLE_FACTORS TBI-9 pos-TBI-11 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071909.raw SUBJECT_SAMPLE_FACTORS TBI-10 pos-TBI-12 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071910.raw SUBJECT_SAMPLE_FACTORS TBI-11 pos-TBI-13 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071911.raw SUBJECT_SAMPLE_FACTORS TBI-12 pos-TBI-14 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071912.raw SUBJECT_SAMPLE_FACTORS TBI-13 pos-TBI-15 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071913.raw SUBJECT_SAMPLE_FACTORS TBI-14 pos-TBI-16 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071914.raw SUBJECT_SAMPLE_FACTORS TBI-15 pos-TBI-17 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071915.raw SUBJECT_SAMPLE_FACTORS TBI-16 pos-TBI-18 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071916.raw SUBJECT_SAMPLE_FACTORS TBI-18 pos-TBI-19 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071918.raw SUBJECT_SAMPLE_FACTORS TBI-19 pos-TBI-20 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071919.raw SUBJECT_SAMPLE_FACTORS TBI-20 pos-TBI-21 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071920.raw SUBJECT_SAMPLE_FACTORS TBI-21 pos-TBI-22 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071921.raw SUBJECT_SAMPLE_FACTORS TBI-22 pos-TBI-23 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071922.raw SUBJECT_SAMPLE_FACTORS TBI-23 pos-TBI-24 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071923.raw SUBJECT_SAMPLE_FACTORS TBI-24 pos-TBI-25 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071924.raw SUBJECT_SAMPLE_FACTORS TBI-25 pos-TBI-26 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071925.raw SUBJECT_SAMPLE_FACTORS TBI-27 pos-TBI-27 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071927.raw SUBJECT_SAMPLE_FACTORS TBI-28 pos-TBI-28 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071928.raw SUBJECT_SAMPLE_FACTORS TBI-29 pos-TBI-29 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071929.raw SUBJECT_SAMPLE_FACTORS TBI-30 pos-TBI-30 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071930.raw SUBJECT_SAMPLE_FACTORS TBI-31 pos-TBI-31 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071931.raw SUBJECT_SAMPLE_FACTORS TBI-32 pos-TBI-32 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071932.raw SUBJECT_SAMPLE_FACTORS TBI-33 pos-TBI-33 Treatment:TBI Sex=Female; Batch=1b; RAW_FILE_NAME=2018071933.raw SUBJECT_SAMPLE_FACTORS TBI-35 pos-TBI-34 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071935.raw SUBJECT_SAMPLE_FACTORS TBI-36 pos-TBI-35 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071936.raw SUBJECT_SAMPLE_FACTORS TBI-37 pos-TBI-36 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071937.raw SUBJECT_SAMPLE_FACTORS TBI-38 pos-TBI-37 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071938.raw SUBJECT_SAMPLE_FACTORS TBI-39 pos-TBI-38 Treatment:TBI Sex=Male; Batch=1b; RAW_FILE_NAME=2018071939.raw SUBJECT_SAMPLE_FACTORS TBI-50 GC-Pre-TBI-1 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A1.CDF SUBJECT_SAMPLE_FACTORS TBI-58 GC-Pre-TBI-2 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A2.CDF SUBJECT_SAMPLE_FACTORS TBI-41 GC-Pre-TBI-5 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A3.CDF SUBJECT_SAMPLE_FACTORS TBI-55 GC-Pre-TBI-6 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A4.CDF SUBJECT_SAMPLE_FACTORS TBI-67 GC-Pre-TBI-7 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A5.CDF SUBJECT_SAMPLE_FACTORS TBI-49 GC-Pre-TBI-8 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A6.CDF SUBJECT_SAMPLE_FACTORS TBI-52 GC-Pre-TBI-9 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A7.CDF SUBJECT_SAMPLE_FACTORS TBI-48 GC-Pre-TBI-10 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A8.CDF SUBJECT_SAMPLE_FACTORS TBI-70 GC-Pre-TBI-11 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A9.CDF SUBJECT_SAMPLE_FACTORS TBI-64 GC-Pre-TBI-12 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A10.CDF SUBJECT_SAMPLE_FACTORS TBI-71 GC-Pre-TBI-13 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A11.CDF SUBJECT_SAMPLE_FACTORS TBI-53 GC-Pre-TBI-14 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A12.CDF SUBJECT_SAMPLE_FACTORS TBI-76 GC-Pre-TBI-15 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A13.CDF SUBJECT_SAMPLE_FACTORS TBI-47 GC-Pre-TBI-16 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A14.CDF SUBJECT_SAMPLE_FACTORS TBI-59 GC-Pre-TBI-17 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A15.CDF SUBJECT_SAMPLE_FACTORS TBI-72 GC-Pre-TBI-18 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A16.CDF SUBJECT_SAMPLE_FACTORS TBI-57 GC-Pre-TBI-19 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A18.CDF SUBJECT_SAMPLE_FACTORS TBI-45 GC-Pre-TBI-20 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A19.CDF SUBJECT_SAMPLE_FACTORS TBI-43 GC-Pre-TBI-21 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A20.CDF SUBJECT_SAMPLE_FACTORS TBI-68 GC-Pre-TBI-22 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A21.CDF SUBJECT_SAMPLE_FACTORS TBI-73 GC-Pre-TBI-23 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A22.CDF SUBJECT_SAMPLE_FACTORS TBI-78 GC-Pre-TBI-24 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A23.CDF SUBJECT_SAMPLE_FACTORS TBI-77 GC-Pre-TBI-25 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A24.CDF SUBJECT_SAMPLE_FACTORS TBI-61 GC-Pre-TBI-26 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A25.CDF SUBJECT_SAMPLE_FACTORS TBI-66 GC-Pre-TBI-27 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A27.CDF SUBJECT_SAMPLE_FACTORS TBI-75 GC-Pre-TBI-28 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A28.CDF SUBJECT_SAMPLE_FACTORS TBI-62 GC-Pre-TBI-29 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A29.CDF SUBJECT_SAMPLE_FACTORS TBI-74 GC-Pre-TBI-30 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A30.CDF SUBJECT_SAMPLE_FACTORS TBI-56 GC-Pre-TBI-31 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A31.CDF SUBJECT_SAMPLE_FACTORS TBI-60 GC-Pre-TBI-32 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A32.CDF SUBJECT_SAMPLE_FACTORS TBI-69 GC-Pre-TBI-33 Treatment:Control Sex=Female; Batch=2; RAW_FILE_NAME=TBI-A33.CDF SUBJECT_SAMPLE_FACTORS TBI-46 GC-Pre-TBI-34 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A35.CDF SUBJECT_SAMPLE_FACTORS TBI-79 GC-Pre-TBI-35 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A36.CDF SUBJECT_SAMPLE_FACTORS TBI-65 GC-Pre-TBI-36 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A37.CDF SUBJECT_SAMPLE_FACTORS TBI-63 GC-Pre-TBI-37 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A38.CDF SUBJECT_SAMPLE_FACTORS TBI-42 GC-Pre-TBI-38 Treatment:Control Sex=Male; Batch=2; RAW_FILE_NAME=TBI-A39.CDF SUBJECT_SAMPLE_FACTORS TBI-1 GC-TBI-1 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-1.CDF SUBJECT_SAMPLE_FACTORS TBI-2 GC-TBI-2 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-2.CDF SUBJECT_SAMPLE_FACTORS TBI-3 GC-TBI-5 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-3.CDF SUBJECT_SAMPLE_FACTORS TBI-4 GC-TBI-6 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-4.CDF SUBJECT_SAMPLE_FACTORS TBI-5 GC-TBI-7 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-5.CDF SUBJECT_SAMPLE_FACTORS TBI-6 GC-TBI-8 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-6.CDF SUBJECT_SAMPLE_FACTORS TBI-7 GC-TBI-9 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-7.CDF SUBJECT_SAMPLE_FACTORS TBI-8 GC-TBI-10 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-8.CDF SUBJECT_SAMPLE_FACTORS TBI-9 GC-TBI-11 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-9.CDF SUBJECT_SAMPLE_FACTORS TBI-10 GC-TBI-12 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-10.CDF SUBJECT_SAMPLE_FACTORS TBI-11 GC-TBI-13 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-11.CDF SUBJECT_SAMPLE_FACTORS TBI-12 GC-TBI-14 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-12.CDF SUBJECT_SAMPLE_FACTORS TBI-13 GC-TBI-15 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-13.CDF SUBJECT_SAMPLE_FACTORS TBI-14 GC-TBI-16 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-14.CDF SUBJECT_SAMPLE_FACTORS TBI-15 GC-TBI-17 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-15.CDF SUBJECT_SAMPLE_FACTORS TBI-16 GC-TBI-18 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-16.CDF SUBJECT_SAMPLE_FACTORS TBI-18 GC-TBI-19 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-18.CDF SUBJECT_SAMPLE_FACTORS TBI-19 GC-TBI-20 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-19.CDF SUBJECT_SAMPLE_FACTORS TBI-20 GC-TBI-21 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-20.CDF SUBJECT_SAMPLE_FACTORS TBI-21 GC-TBI-22 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-21.CDF SUBJECT_SAMPLE_FACTORS TBI-22 GC-TBI-23 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-22.CDF SUBJECT_SAMPLE_FACTORS TBI-23 GC-TBI-24 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-23.CDF SUBJECT_SAMPLE_FACTORS TBI-24 GC-TBI-25 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-24.CDF SUBJECT_SAMPLE_FACTORS TBI-25 GC-TBI-26 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-25.CDF SUBJECT_SAMPLE_FACTORS TBI-27 GC-TBI-27 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-27.CDF SUBJECT_SAMPLE_FACTORS TBI-28 GC-TBI-28 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-28.CDF SUBJECT_SAMPLE_FACTORS TBI-29 GC-TBI-29 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-29.CDF SUBJECT_SAMPLE_FACTORS TBI-30 GC-TBI-30 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-30.CDF SUBJECT_SAMPLE_FACTORS TBI-31 GC-TBI-31 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-31.CDF SUBJECT_SAMPLE_FACTORS TBI-32 GC-TBI-32 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-32.CDF SUBJECT_SAMPLE_FACTORS TBI-33 GC-TBI-33 Treatment:TBI Sex=Female; Batch=2; RAW_FILE_NAME=TBI-33.CDF SUBJECT_SAMPLE_FACTORS TBI-35 GC-TBI-34 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-35.CDF SUBJECT_SAMPLE_FACTORS TBI-36 GC-TBI-35 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-36.CDF SUBJECT_SAMPLE_FACTORS TBI-37 GC-TBI-36 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-37.CDF SUBJECT_SAMPLE_FACTORS TBI-38 GC-TBI-37 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-38.CDF SUBJECT_SAMPLE_FACTORS TBI-39 GC-TBI-38 Treatment:TBI Sex=Male; Batch=2; RAW_FILE_NAME=TBI-39.CDF #COLLECTION CO:COLLECTION_SUMMARY whole blood was collected prior to irradiation (3 days before the first dose of CO:COLLECTION_SUMMARY TBI) and at approximately 72h after the end of radiation. CO:SAMPLE_TYPE Blood (whole) #TREATMENT TR:TREATMENT_SUMMARY 36 patients (28 male and 8 female) received 2 Gy twice a day for three TR:TREATMENT_SUMMARY consecutive days (total dose of 12 Gy) at a dose rate 8cGy/min using a six MV TR:TREATMENT_SUMMARY medical linear accelerator (Siemens, KD22). The lung was shielded and the dose TR:TREATMENT_SUMMARY of supplemental electron fields was no more than 8 Gy. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY GC-MS： 200μL of methanol containing 0.5μg/ml tridecanoic acid (IS) was added SP:SAMPLEPREP_SUMMARY into 50μL plasma. After vortexmixing, the solution was centrifuged at 13000 rpm SP:SAMPLEPREP_SUMMARY for 15 min at 4 ℃. Then the supernatant was transferred into a new eppendorf SP:SAMPLEPREP_SUMMARY tube and dried by vacuum (LABCONCO, USA). The dried sample was re-dissolved in SP:SAMPLEPREP_SUMMARY 50μL methoxyamine solution (20 mg/mL) for the oximation reaction (37℃,1.5h), SP:SAMPLEPREP_SUMMARY which was followed by a silylation reaction with 50μL MSTFA (37℃,1.5h). SP:SAMPLEPREP_SUMMARY Finally, the derivatized sample was centrifuged at 13 000 rpm for 15 min and the SP:SAMPLEPREP_SUMMARY supernatant was used for the GC-MS analysis. LC-MS： The internal standards SP:SAMPLEPREP_SUMMARY (ISs) were dissolved in acetonitrile including d4-choline (d4-CA, 8μg/mL), SP:SAMPLEPREP_SUMMARY C19:0 lysoPC (4μg/mL), C17:0-C17:0 PC (8μg/mL), C17:0-C17:0 PE (8μg/mL), SP:SAMPLEPREP_SUMMARY d3-C16:0 free fatty acids (d3-C16:0 FFA, 8μg/mL), d4-cholic acid (CA, 4μg/mL) SP:SAMPLEPREP_SUMMARY and d4-chenodeoxycholic acid (d4-CDCA, 4μg/mL). For LC-MS analysis, 200 μL ISs SP:SAMPLEPREP_SUMMARY was added into 50 μL plasma sample for the protein precipitation. After SP:SAMPLEPREP_SUMMARY vortexing, the sample was centrifuged for 10 min (14,000 rpm, 4 ℃), the SP:SAMPLEPREP_SUMMARY supernatant (180 μL ) was redissolved with 100μ L 50% methanol before LC-MS SP:SAMPLEPREP_SUMMARY analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY negative ion mode CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Thermo TSQ Vantage HPLC-MS/MS CH:COLUMN_NAME Waters ACQUITY UPLC HSS T3 (100 x 2.1mm,1.8um) CH:SOLVENT_A water(5 mM ammonium bicarbonate ) CH:SOLVENT_B 95% methanol/water(5mM ammonium bicarbonate ) CH:FLOW_GRADIENT 0-1min，0.1%B；1-3min，0.1-40%B；3-5min，40-100%B；5-10.5min，100%B；10.5-10.6min，0.1%B；10.6-18min CH:FLOW_RATE 0.25 mL/min CH:COLUMN_TEMPERATURE 50 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo TSQ Vantage MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS 350℃capillary temperature, 300℃ vaporize temperature, 40 arbitrary units MS:MS_COMMENTS sheath gas flow rate, 20 arbitrary units auxiliary gas flow rate, -2.5 kV MS:MS_COMMENTS capillary voltage #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS pmoles/l MS_METABOLITE_DATA_START Samples neg-Pre-TBI-1 neg-Pre-TBI-2 neg-Pre-TBI-5 neg-Pre-TBI-6 neg-Pre-TBI-7 neg-Pre-TBI-8 neg-Pre-TBI-9 neg-Pre-TBI-10 neg-Pre-TBI-11 neg-Pre-TBI-12 neg-Pre-TBI-13 neg-Pre-TBI-14 neg-Pre-TBI-15 neg-Pre-TBI-16 neg-Pre-TBI-17 neg-Pre-TBI-18 neg-Pre-TBI-19 neg-Pre-TBI-20 neg-Pre-TBI-21 neg-Pre-TBI-22 neg-Pre-TBI-23 neg-Pre-TBI-24 neg-Pre-TBI-25 neg-Pre-TBI-26 neg-Pre-TBI-27 neg-Pre-TBI-28 neg-Pre-TBI-29 neg-Pre-TBI-30 neg-Pre-TBI-31 neg-Pre-TBI-32 neg-Pre-TBI-33 neg-Pre-TBI-34 neg-Pre-TBI-35 neg-Pre-TBI-36 neg-Pre-TBI-37 neg-Pre-TBI-38 neg-TBI-1 neg-TBI-2 neg-TBI-5 neg-TBI-6 neg-TBI-7 neg-TBI-8 neg-TBI-9 neg-TBI-10 neg-TBI-11 neg-TBI-12 neg-TBI-13 neg-TBI-14 neg-TBI-15 neg-TBI-16 neg-TBI-17 neg-TBI-18 neg-TBI-19 neg-TBI-20 neg-TBI-21 neg-TBI-22 neg-TBI-23 neg-TBI-24 neg-TBI-25 neg-TBI-26 neg-TBI-27 neg-TBI-28 neg-TBI-29 neg-TBI-30 neg-TBI-31 neg-TBI-32 neg-TBI-33 neg-TBI-34 neg-TBI-35 neg-TBI-36 neg-TBI-37 neg-TBI-38 Factors Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI Treatment:TBI hippuric acid 14.42 11.34 13.85 9.50 11.28 10.33 9.22 8.74 12.25 7.72 11.78 8.54 8.85 12.14 7.55 8.72 8.57 9.00 10.39 8.60 8.93 8.82 8.03 8.06 10.96 12.04 7.90 9.72 7.55 9.15 8.58 8.51 9.37 12.01 9.41 7.64 10.17 8.85 11.21 16.41 11.81 15.24 16.16 11.84 12.64 11.92 12.42 14.47 11.12 14.74 15.12 13.06 11.99 13.21 14.73 13.78 10.59 14.05 16.89 11.30 10.69 12.08 13.23 10.25 8.98 11.02 9.59 10.73 15.87 9.55 8.67 8.14 phenyalanine 0.04 0.02 0.03 0.02 0.03 0.09 0.03 0.03 0.05 0.04 0.07 0.05 0.04 0.04 0.03 0.02 0.02 0.02 0.03 0.04 0.04 0.04 0.03 0.04 0.03 0.06 0.03 0.02 0.02 0.04 0.03 0.02 0.03 0.03 0.02 0.02 0.02 0.01 0.02 0.05 0.02 0.05 0.07 0.03 0.04 0.02 0.07 0.08 0.04 0.06 0.05 0.04 0.03 0.05 0.04 0.04 0.03 0.06 0.05 0.04 0.03 0.04 0.05 0.02 0.02 0.02 0.03 0.02 0.04 0.02 0.01 0.01 urate 0.15 0.05 0.10 0.09 0.18 0.10 0.13 0.04 0.25 0.08 0.10 0.11 0.17 0.11 0.07 0.17 0.07 0.11 0.10 0.16 0.17 0.10 0.13 0.15 0.21 0.20 0.20 0.16 0.19 0.10 0.07 0.17 0.17 0.23 0.09 0.14 0.13 0.04 0.10 0.15 0.05 0.14 0.07 0.05 0.13 0.07 0.10 0.11 0.09 0.12 0.05 0.13 0.06 0.11 0.08 0.11 0.07 0.24 0.06 0.10 0.13 0.08 0.08 0.05 0.08 0.09 0.03 0.13 0.11 0.07 0.09 0.04 hippuric acid2 0.02 0.01 0.02 0.00 0.02 0.01 0.00 0.00 0.01 0.19 0.01 0.00 0.01 0.01 0.00 0.02 0.00 0.00 0.01 0.01 0.01 0.00 0.02 0.01 0.06 0.01 0.01 0.00 0.00 0.02 0.01 0.01 0.00 0.02 0.01 0.00 0.01 0.00 0.07 0.02 0.01 0.01 0.04 0.00 0.01 0.01 0.01 0.04 0.00 0.01 0.01 0.01 0.00 0.02 0.01 0.03 0.00 0.01 0.02 0.01 0.00 0.00 0.00 0.00 0.00 0.01 0.00 0.01 0.03 0.04 0.00 0.00 Tryptophan 0.15 0.06 0.13 0.12 0.07 0.15 0.07 0.08 0.12 0.07 0.19 0.07 0.11 0.16 0.10 0.13 0.11 0.10 0.08 0.10 0.11 0.09 0.09 0.08 0.19 0.17 0.10 0.11 0.12 0.08 0.07 0.11 0.16 0.16 0.11 0.05 0.16 0.04 0.09 0.26 0.22 0.18 0.16 0.25 0.16 0.09 0.21 0.15 0.06 0.22 0.24 0.18 0.20 0.16 0.17 0.30 0.17 0.20 0.35 0.10 0.16 0.13 0.23 0.11 0.05 0.11 0.07 0.05 0.14 0.05 0.05 0.05 FFA14:0 0.11 0.20 0.14 0.07 0.23 0.23 0.11 0.15 0.14 0.24 0.16 0.32 0.23 0.06 0.17 0.07 0.15 0.07 0.08 0.40 0.23 0.11 0.11 0.06 0.09 0.10 0.16 0.10 0.10 0.42 0.14 0.18 0.16 0.07 0.11 0.12 0.36 0.22 0.18 1.21 0.18 0.25 0.11 0.13 0.39 0.09 0.43 0.16 0.21 0.23 0.14 0.10 0.16 0.14 0.20 0.09 0.49 0.16 0.18 0.25 0.12 0.12 0.19 0.11 0.21 0.37 0.06 0.15 0.08 0.21 0.08 0.11 FFA16:0 1.38 2.19 2.18 0.93 2.60 3.04 1.34 2.68 2.14 3.75 2.56 5.83 0.78 1.51 2.25 1.24 1.22 1.29 1.11 6.69 0.94 1.37 2.18 1.57 0.88 1.94 3.00 1.60 1.32 7.46 1.49 1.88 1.34 1.92 1.69 2.07 0.83 2.49 3.24 9.87 2.39 3.84 1.64 2.01 5.54 1.48 4.44 3.33 7.00 3.76 2.69 2.53 2.74 2.28 3.29 2.35 5.58 2.44 2.89 1.28 1.47 1.78 1.93 1.71 2.78 2.63 1.38 1.88 0.92 4.16 2.31 1.66 FFA17:1 0.19 0.40 0.62 0.29 0.62 0.86 0.29 1.01 0.52 1.26 0.73 1.87 0.16 0.38 0.72 0.37 0.25 0.34 0.28 1.29 0.31 0.29 0.51 0.39 0.13 0.39 0.82 0.38 0.37 3.02 0.31 0.88 0.36 0.45 0.38 0.49 0.19 0.55 1.12 2.22 0.73 1.36 0.38 0.77 1.91 0.41 1.44 1.02 1.18 1.58 0.85 0.79 0.77 0.96 1.21 0.63 1.60 0.61 0.77 0.44 0.38 0.53 0.52 0.56 0.88 1.16 0.35 0.68 0.32 1.28 0.26 0.44 FFA18:3 0.33 1.86 2.22 0.71 1.78 3.05 0.95 1.51 1.64 4.12 2.53 5.33 0.24 1.34 1.74 1.09 0.99 0.62 0.49 5.05 0.76 0.86 1.34 1.19 0.51 1.85 1.88 0.69 1.42 8.28 0.69 3.17 0.77 0.82 0.83 0.94 0.25 2.01 4.91 10.87 3.45 4.10 1.36 1.27 8.07 1.78 6.02 5.65 71.16 5.59 1.67 3.44 3.35 2.18 2.32 1.90 11.31 1.58 2.34 0.95 1.33 2.71 1.51 0.86 8.35 2.71 0.90 2.46 0.43 4.74 13.23 0.80 FFA18:2 8.52 69.31 67.86 25.87 71.19 109.21 43.01 64.84 63.50 135.87 66.83 211.13 10.06 38.41 72.31 36.70 27.35 30.38 30.63 194.33 21.86 29.72 62.45 56.27 16.90 41.69 104.48 39.78 29.83 331.88 46.66 81.40 30.63 44.69 34.83 37.54 7.69 88.17 163.88 197.21 101.26 143.40 54.23 51.20 251.63 41.53 148.20 152.08 778.02 139.74 89.52 100.93 88.39 93.01 107.12 84.74 274.02 76.76 70.94 43.72 33.69 86.50 63.68 42.96 143.51 99.36 44.56 76.47 18.41 189.51 226.60 32.95 FFA18:1 25.71 224.51 197.22 75.77 284.27 295.11 117.69 235.71 181.00 391.51 213.73 595.03 25.86 141.44 284.04 96.99 70.53 108.13 117.05 565.51 57.21 108.03 194.18 150.39 41.23 150.15 276.42 133.75 101.66 796.44 137.59 198.38 120.06 199.55 146.57 174.68 23.48 288.02 377.45 635.93 253.93 393.51 133.59 196.69 553.11 80.51 409.38 347.78 862.49 436.42 344.26 270.51 290.39 324.52 377.87 265.31 478.39 224.16 299.90 119.05 135.72 191.59 158.87 158.88 317.34 268.19 127.49 207.79 63.41 470.30 222.70 142.59 FFA18:0 0.92 0.88 0.95 0.64 1.26 0.97 0.75 0.95 0.84 1.52 1.41 2.19 0.58 0.82 1.04 0.65 0.54 0.64 0.56 2.14 0.52 0.70 1.12 0.78 0.72 1.08 1.16 0.80 0.82 2.64 0.90 0.92 1.02 1.10 0.81 1.12 0.56 0.97 1.18 3.16 0.87 1.11 0.70 0.75 1.52 0.60 1.17 1.54 4.40 1.41 1.37 1.07 0.89 0.86 1.24 0.96 1.26 1.01 1.17 0.64 0.64 0.81 0.80 0.77 1.04 0.91 0.61 0.92 0.49 0.92 1.19 0.63 FFA20:5 2.63 2.55 3.12 2.38 3.58 2.87 2.45 2.67 2.50 2.84 3.36 4.12 2.70 0.74 2.74 2.55 2.50 2.43 2.28 3.65 2.62 2.37 2.44 2.63 0.77 0.76 2.98 2.71 2.72 4.07 3.11 2.61 3.24 4.41 3.03 4.12 2.04 2.33 4.30 3.78 2.25 3.14 3.22 2.70 4.02 2.55 3.03 3.11 5.23 3.53 3.47 2.88 3.31 2.91 3.69 2.96 3.46 2.94 3.26 2.50 2.85 2.75 3.04 2.84 3.19 3.33 2.45 2.38 2.50 2.89 2.45 2.29 FFA20:4 0.81 1.19 1.61 0.42 1.64 1.77 0.57 1.67 1.37 2.08 1.60 2.38 0.56 0.94 0.73 0.96 0.67 0.51 0.82 3.25 0.54 0.73 1.16 0.99 0.65 0.68 2.38 0.52 1.21 5.87 0.94 0.48 0.59 0.71 0.71 0.82 0.67 1.06 1.23 10.97 1.55 1.80 0.88 1.15 3.73 0.80 2.57 1.50 1.05 2.20 0.87 1.11 1.06 1.04 1.50 1.34 2.66 1.61 1.44 0.66 0.59 0.93 1.26 0.71 1.38 1.78 0.62 0.61 0.72 2.78 0.49 0.47 FFA20:3 0.65 1.23 2.68 0.69 2.05 1.90 1.01 2.25 1.71 3.92 3.11 5.68 0.62 1.58 1.37 0.96 0.66 0.63 0.93 4.87 0.68 0.80 1.89 1.07 0.44 1.18 2.96 1.41 1.18 8.87 0.93 0.82 0.72 0.80 0.73 0.84 0.98 1.22 2.51 19.24 2.19 2.83 0.94 0.91 5.12 1.22 8.64 2.17 2.66 3.33 1.48 2.18 2.04 2.10 1.94 1.74 6.58 2.19 1.80 1.12 0.92 1.73 1.50 0.94 3.19 2.47 0.83 1.24 0.48 2.97 0.54 0.61 FFA20:1 1.42 9.07 8.02 2.95 20.86 8.41 4.47 9.40 5.44 15.28 8.41 26.60 1.61 6.35 18.31 3.11 2.22 3.08 5.57 15.91 1.84 3.66 6.66 5.15 2.09 7.81 8.98 5.02 12.27 30.33 4.32 6.03 4.59 10.03 6.32 6.41 0.86 9.20 12.59 25.79 8.84 14.51 3.80 6.24 15.56 2.63 11.28 12.39 35.40 22.00 26.98 9.75 8.62 13.26 10.59 9.69 9.85 6.63 10.25 4.65 6.61 5.08 4.39 9.00 18.46 16.71 4.50 7.31 2.17 8.08 10.14 4.54 phe-phe 0.01 0.00 0.03 0.01 0.03 0.02 0.01 0.02 0.02 0.01 0.07 0.01 0.02 0.04 0.02 0.02 0.00 0.01 0.01 0.02 0.03 0.01 0.03 0.03 0.02 0.03 0.04 0.02 0.03 0.02 0.03 0.01 0.04 0.01 0.01 0.01 0.01 0.00 0.02 0.20 0.03 0.08 0.08 0.00 0.03 0.07 0.10 0.01 0.06 0.09 0.07 0.13 0.02 0.07 0.05 0.08 0.03 0.06 0.12 0.06 0.21 0.01 0.06 0.03 0.04 0.05 0.12 3.02 0.23 0.00 0.00 0.01 FFA22:6 0.01 0.07 0.19 0.06 0.15 0.09 0.05 0.17 0.17 0.26 0.21 0.51 0.06 0.11 0.09 0.08 0.11 0.06 0.05 0.24 0.09 0.07 0.14 0.08 0.10 0.03 0.15 0.04 0.07 0.55 0.07 0.13 0.06 0.06 0.05 0.07 0.02 0.06 0.12 0.50 0.19 0.10 0.05 0.09 0.65 0.04 0.38 0.18 0.17 0.26 0.14 0.11 0.27 0.09 0.11 0.13 0.11 0.12 0.09 0.06 0.03 0.15 0.08 0.03 0.15 0.33 0.06 0.15 0.04 0.36 0.05 0.07 FFA24:0 2.51 3.34 2.71 2.54 2.38 4.33 1.95 5.60 1.47 2.30 1.60 2.36 1.81 0.77 1.33 4.93 2.56 1.57 2.78 5.07 2.32 2.30 2.89 1.20 1.59 1.80 2.68 1.25 0.46 3.70 2.68 1.43 1.65 2.90 3.44 1.62 5.71 4.62 0.90 3.46 2.36 5.21 3.80 4.85 5.65 1.70 2.12 2.71 4.78 1.59 2.91 2.63 4.13 1.48 2.57 2.88 2.64 2.43 2.78 1.42 2.16 3.17 3.29 0.74 3.57 2.31 3.13 1.24 3.06 2.30 1.47 1.07 DCA(Deoxycholic acid) 0.07 0.01 0.01 0.02 0.02 0.01 0.02 0.01 0.02 0.01 0.02 0.02 0.03 0.01 0.01 0.21 0.02 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.04 0.01 0.03 0.01 0.01 0.02 0.02 0.03 0.02 0.02 0.01 0.01 0.02 0.03 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.02 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 UDCA(Ursodeoxycholic acid) 0.15 0.02 0.02 0.03 0.03 0.02 0.05 0.02 0.02 0.03 0.02 0.02 0.05 0.02 0.03 0.46 0.03 0.03 0.03 0.02 0.02 0.02 0.02 0.02 0.09 0.02 0.07 0.02 0.02 0.02 0.02 0.06 0.05 0.04 0.02 0.02 0.04 0.07 0.02 0.03 0.03 0.02 0.03 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.02 0.02 0.03 0.02 0.03 0.03 0.02 0.02 0.02 0.02 0.02 0.02 0.03 0.02 0.02 CA(Cholic acid) 0.05 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.05 0.05 0.04 0.04 0.11 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.05 0.04 0.05 0.04 0.04 0.06 0.04 0.04 0.04 0.12 0.04 0.04 0.05 0.04 0.04 0.05 0.05 0.04 0.04 0.05 0.04 0.04 0.04 0.04 0.05 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.05 0.04 0.04 0.04 GUDCA（Glycoursodeoxycholic acid） 0.23 0.83 0.23 0.22 0.07 2.31 0.32 0.61 0.69 0.61 0.78 0.21 0.46 0.08 0.16 1.22 0.19 0.09 0.24 0.81 0.38 0.54 0.31 0.58 0.26 4.60 0.35 0.15 0.32 0.31 0.31 0.23 3.59 0.64 0.04 0.12 0.27 0.04 0.46 0.70 0.07 1.58 0.22 0.02 0.17 0.08 0.30 0.22 0.18 0.19 0.76 0.09 0.79 0.12 0.05 0.24 0.05 0.10 0.10 0.86 3.20 0.16 0.02 0.14 0.11 0.06 0.05 1.35 1.96 0.07 0.09 0.16 GDCA(Glycodeoxycholic acid) 0.02 0.01 0.00 0.00 0.00 0.03 0.01 0.01 0.01 0.00 0.01 0.00 0.01 0.00 0.00 0.09 0.00 0.01 0.00 0.01 0.00 0.00 0.00 0.01 0.02 0.04 0.06 0.00 0.01 0.01 0.01 0.02 0.07 0.03 0.00 0.00 0.02 0.00 0.01 0.01 0.00 0.02 0.01 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.01 0.00 0.01 0.00 0.00 0.00 0.00 0.00 0.00 0.01 0.03 0.00 0.00 0.00 0.00 0.00 0.00 0.05 0.03 0.01 0.00 0.00 GCA(glycocholic acid) 0.01 0.03 0.01 0.01 0.00 0.05 0.01 0.02 0.02 0.02 0.01 0.00 0.01 0.00 0.00 0.03 0.00 0.00 0.02 0.03 0.01 0.02 0.02 0.01 0.00 0.13 0.01 0.01 0.01 0.02 0.02 0.01 0.27 0.04 0.00 0.01 0.01 0.00 0.01 0.05 0.00 0.06 0.03 0.00 0.01 0.02 0.01 0.02 0.01 0.01 0.04 0.01 0.05 0.02 0.01 0.01 0.00 0.01 0.01 0.04 0.17 0.00 0.02 0.01 0.01 0.00 0.00 0.07 0.24 0.00 0.01 0.01 TDCA(Taurodeoxycholic acid) 0.03 0.06 0.02 0.01 0.01 0.11 0.02 0.06 0.05 0.06 0.05 0.01 0.02 0.01 0.03 0.04 0.02 0.02 0.06 0.04 0.02 0.03 0.04 0.04 0.02 0.20 0.07 0.01 0.01 0.03 0.03 0.03 0.20 0.12 0.01 0.02 0.02 0.01 0.02 0.10 0.01 0.14 0.02 0.01 0.02 0.02 0.02 0.02 0.02 0.03 0.04 0.01 0.04 0.01 0.01 0.01 0.01 0.03 0.01 0.05 0.29 0.01 0.01 0.02 0.01 0.01 0.01 0.06 0.10 0.01 0.01 0.03 TUDCA（Tauroursodeoxycholic acid） 0.03 0.05 0.01 0.01 0.01 0.09 0.02 0.05 0.04 0.05 0.04 0.01 0.02 0.01 0.02 0.04 0.02 0.02 0.05 0.02 0.02 0.03 0.03 0.04 0.02 0.16 0.05 0.01 0.01 0.02 0.03 0.03 0.15 0.10 0.01 0.02 0.02 0.01 0.02 0.09 0.01 0.10 0.02 0.00 0.02 0.01 0.02 0.01 0.02 0.02 0.03 0.01 0.04 0.01 0.00 0.01 0.01 0.02 0.01 0.04 0.24 0.01 0.00 0.02 0.01 0.01 0.01 0.05 0.09 0.01 0.01 0.02 TCDCA(Taurochenodesoxycholic acid) 0.05 0.09 0.02 0.02 0.02 0.16 0.04 0.08 0.07 0.09 0.07 0.03 0.04 0.02 0.04 0.08 0.03 0.04 0.09 0.05 0.03 0.05 0.05 0.06 0.03 0.27 0.11 0.03 0.02 0.04 0.05 0.05 0.27 0.17 0.01 0.03 0.03 0.01 0.04 0.14 0.01 0.18 0.04 0.01 0.03 0.02 0.03 0.03 0.04 0.05 0.06 0.02 0.07 0.02 0.01 0.02 0.02 0.04 0.02 0.07 0.36 0.02 0.02 0.03 0.02 0.02 0.01 0.08 0.15 0.02 0.02 0.04 TCA(Taurocholic acid) 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.01 0.00 0.00 0.00 0.00 0.00 0.00 0.01 0.00 0.00 0.00 0.00 0.00 0.00 0.07 0.01 0.00 0.00 0.00 0.00 0.00 0.01 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.01 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.03 0.00 0.00 0.00 0.00 0.00 0.00 0.01 0.03 0.00 0.00 0.00 GCDCS(Glycochenodeoxycholic acid ) 0.61 0.72 0.05 0.09 0.12 0.19 0.38 0.04 0.16 0.58 0.09 0.05 0.02 0.01 0.02 0.12 0.02 0.01 0.05 0.33 0.03 0.06 0.09 0.13 0.02 0.05 0.06 0.03 0.02 0.05 0.15 0.04 0.05 0.34 0.11 0.02 0.21 0.01 0.02 0.05 0.02 0.03 0.06 0.03 0.01 0.02 0.10 0.07 0.00 0.06 0.03 0.03 0.02 0.03 0.02 0.17 0.01 0.07 0.06 0.07 0.05 0.04 0.09 0.03 0.04 0.05 0.03 0.00 0.04 0.03 0.01 0.02 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name hippuric acid phenyalanine urate hippuric acid2 Tryptophan FFA14:0 FFA16:0 FFA17:1 FFA18:3 FFA18:2 FFA18:1 FFA18:0 FFA20:5 FFA20:4 FFA20:3 FFA20:1 phe-phe FFA22:6 FFA24:0 DCA(Deoxycholic acid) UDCA(Ursodeoxycholic acid) CA(Cholic acid) GUDCA（Glycoursodeoxycholic acid） GDCA(Glycodeoxycholic acid) GCA(glycocholic acid) TDCA(Taurodeoxycholic acid) TUDCA（Tauroursodeoxycholic acid） TCDCA(Taurochenodesoxycholic acid) TCA(Taurocholic acid) GCDCS(Glycochenodeoxycholic acid ) METABOLITES_END #END