#METABOLOMICS WORKBENCH hjyoo2_20230330_221455 DATATRACK_ID:3829 STUDY_ID:ST002550 ANALYSIS_ID:AN004198 PROJECT_ID:PR001642
VERSION             	1
CREATED_ON             	April 7, 2023, 3:26 pm
#PROJECT
PR:PROJECT_TITLE                 	Targeted metabolomics for ARDS
PR:PROJECT_SUMMARY               	Acute respiratory distress syndrome (ARDS) is a heterogeneous disease in its
PR:PROJECT_SUMMARY               	etiology and clinical aspects, and it has been an important interest in how to
PR:PROJECT_SUMMARY               	diagnose it and classify its subtypes, and apply them to treatment. Metabolomics
PR:PROJECT_SUMMARY               	is becoming important for identifying ARDS biology and distinguishing subtypes.
PR:PROJECT_SUMMARY               	The aim of this study is to identify metabolites distinguishing sepsis-induced
PR:PROJECT_SUMMARY               	ARDS patients from healthy controls using a targeted metabolomics approach, and
PR:PROJECT_SUMMARY               	to find out whether direct and indirect ARDS are metabolically distinct groups
PR:PROJECT_SUMMARY               	and confirm their metabolites and associated pathways. Targeted metabolomics was
PR:PROJECT_SUMMARY               	performed to explore metabolome changes between pARDS (pediatric ARDS) and
PR:PROJECT_SUMMARY               	eARDS.
PR:INSTITUTE                     	Asan Medical Center
PR:LAST_NAME                     	Yoo
PR:FIRST_NAME                    	Hyun Ju
PR:ADDRESS                       	88, Olympic-ro 43-gil, Songpa-gu
PR:EMAIL                         	yoohyunju@amc.seoul.kr
PR:PHONE                         	0230104029
#STUDY
ST:STUDY_TITLE                   	Targeted metabolomics for ARDS
ST:STUDY_SUMMARY                 	Acute respiratory distress syndrome (ARDS) is a heterogeneous disease in its
ST:STUDY_SUMMARY                 	etiology and clinical aspects, and it has been an important interest in how to
ST:STUDY_SUMMARY                 	diagnose it and classify its subtypes, and apply them to treatment. Metabolomics
ST:STUDY_SUMMARY                 	is becoming important for identifying ARDS biology and distinguishing subtypes.
ST:STUDY_SUMMARY                 	The aim of this study is to identify metabolites distinguishing sepsis-induced
ST:STUDY_SUMMARY                 	ARDS patients from healthy controls using a targeted metabolomics approach, and
ST:STUDY_SUMMARY                 	to find out whether direct and indirect ARDS are metabolically distinct groups
ST:STUDY_SUMMARY                 	and confirm their metabolites and associated pathways. Targeted metabolomics was
ST:STUDY_SUMMARY                 	performed to explore metabolome changes between pARDS (pediatric ARDS) and
ST:STUDY_SUMMARY                 	eARDS.
ST:INSTITUTE                     	Asan Medical Center
ST:LAST_NAME                     	Yoo
ST:FIRST_NAME                    	Hyun Ju
ST:ADDRESS                       	88, Olympic-ro 43-gil, Songpa-gu
ST:EMAIL                         	yoohyunju@amc.seoul.kr
ST:PHONE                         	0230104029
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Male and female
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	D_Serum_1	D_Serum_1	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_1_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_1.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_1_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_2	D_Serum_2	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_2_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_2.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_2_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_3	D_Serum_3	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_3_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_3.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_3_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_4	D_Serum_4	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_4_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_4.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_4_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_5	D_Serum_5	Factor:Control	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-D_Normal serum_5_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-D_Normal serum_5.mzML 20190801_Cer_SM_Human serum_set1_HJW-D_Normal serum_5_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_61	C_Serum_61	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_61_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_61.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_61_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_62	C_Serum_62	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_62_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_62.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_62_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_63	C_Serum_63	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_63_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_63.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_63_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_64	C_Serum_64	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_64_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_64.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_64_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_65	C_Serum_65	Factor:eARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-C_Serum_65_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-C_Serum_65.mzML 20190801_Cer_SM_Human serum_set1_HJW-C_Serum_65_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_31	B_Serum_31	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_31_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_31.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_31_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_32	B_Serum_32	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_32_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_32.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_32_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_33	B_Serum_33	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_33_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_33.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_33_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_34	B_Serum_34	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_34_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_34.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_34_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_35	B_Serum_35	Factor:pARDS	Batch=1; RAW_FILE_NAME=20190802_PC,PE profiling_Human serum_set1_HJW-B_Serum_35_1_100.mzML 20190802_PLS_Human serum_Set1_HJW-B_Serum_35.mzML 20190801_Cer_SM_Human serum_set1_HJW-B_Serum_35_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_6	D_Serum_6	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_6_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_6.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_6_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_7	D_Serum_7	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_7_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_7.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_7_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_8	D_Serum_8	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_8_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_8.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_8_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_9	D_Serum_9	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_9_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_9.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_9_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_10	D_Serum_10	Factor:Control	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-D_Normal serum_10_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-D_Normal serum_10.mzML 20190806_Cer_SM_Human serum_set2_HJW-D_Normal serum_10_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_66	C_Serum_66	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_66_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_66.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_66_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_67	C_Serum_67	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_67_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_67.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_67_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_68	C_Serum_68	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_68_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_68.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_68_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_69	C_Serum_69	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_69_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_69.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_69_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_70	C_Serum_70	Factor:eARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-C_Serum_70_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-C_Serum_70.mzML 20190806_Cer_SM_Human serum_set2_HJW-C_Serum_70_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_36	B_Serum_36	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_36_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_36.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_36_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_37	B_Serum_37	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_37_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_37.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_37_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_38	B_Serum_38	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_38_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_38.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_38_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_39	B_Serum_39	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_39_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_39.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_39_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_40	B_Serum_40	Factor:pARDS	Batch=2; RAW_FILE_NAME=20190808_PC,PE profiling_Human serum_set2_HJW-B_Serum_40_1_100.mzML 20190808_PLS_Human serum_Set2_HJW-B_Serum_40.mzML 20190806_Cer_SM_Human serum_set2_HJW-B_Serum_40_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_11	D_Serum_11	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_11_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_11.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_11_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_12	D_Serum_12	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_12_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_12.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_12_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_13	D_Serum_13	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_13_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_13.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_13_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_14	D_Serum_14	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_14_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_14.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_14_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_15	D_Serum_15	Factor:Control	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-D_Normal serum_15_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-D_Normal serum_15.mzML 20190812_Cer_SM_Human serum_set3_HJW-D_Normal serum_15_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_71	C_Serum_71	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_71_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_71.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_71_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_72	C_Serum_72	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_72_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_72.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_72_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_73	C_Serum_73	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_73_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_73.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_73_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_74	C_Serum_74	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_74_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_74.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_74_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_75	C_Serum_75	Factor:eARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-C_Serum_75_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-C_Serum_75.mzML 20190812_Cer_SM_Human serum_set3_HJW-C_Serum_75_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_41	B_Serum_41	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_41_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_41.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_41_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_42	B_Serum_42	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_42_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_42.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_42_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_43	B_Serum_43	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_43_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_43.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_43_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_44	B_Serum_44	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_44_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_44.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_44_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_45	B_Serum_45	Factor:pARDS	Batch=3; RAW_FILE_NAME=20190813_PC,PE profiling_Human serum_set3_HJW-B_Serum_45_1_100.mzML 20191015_PLS_Human serum_Set3_HJW_real-B_Serum_45.mzML 20190812_Cer_SM_Human serum_set3_HJW-B_Serum_45_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_16	D_Serum_16	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_16_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_16.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_16_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_17	D_Serum_17	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_17_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_17.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_17_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_18	D_Serum_18	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_18_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_18.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_18_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_19	D_Serum_19	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_19_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_19.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_19_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_20	D_Serum_20	Factor:Control	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-D_Normal serum_20_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-D_Normal serum_20.mzML 20191017_Cer_SM_Human serum_set4_HJW-D_Normal serum_20_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_76	C_Serum_76	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_76_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_76.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_76_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_77	C_Serum_77	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_77_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_77.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_77_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_78	C_Serum_78	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_78_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_78.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_78_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_79	C_Serum_79	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_79_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_79.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_79_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_80	C_Serum_80	Factor:eARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-C_Serum_80_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-C_Serum_80.mzML 20191017_Cer_SM_Human serum_set4_HJW-C_Serum_80_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_46	B_Serum_46	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_46_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_46.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_46_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_47	B_Serum_47	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_47_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_47.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_47_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_48	B_Serum_48	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_48_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_48.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_48_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_49	B_Serum_49	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_49_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_49.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_49_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_50	B_Serum_50	Factor:pARDS	Batch=4; RAW_FILE_NAME=20191017_PC,PE profiling_Human serum_set4_HJW-B_Serum_50_1_100.mzML 20191018_PLS_Human serum_Set4_HJW-B_Serum_50.mzML 20191017_Cer_SM_Human serum_set4_HJW-B_Serum_50_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_21	D_Serum_21	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_21_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_21.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_21_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_22	D_Serum_22	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_22_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_22.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_22_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_23	D_Serum_23	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_23_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_23.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_23_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_24	D_Serum_24	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_24_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_24.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_24_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_25	D_Serum_25	Factor:Control	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-D_Normal serum_25_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-D_Normal serum_25.mzML 20191022_Cer_SM_Human serum_set5_HJW-D_Normal serum_25_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_81	C_Serum_81	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_81_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_81.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_81_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_82	C_Serum_82	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_82_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_82.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_82_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_83	C_Serum_83	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_83_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_83.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_83_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_84	C_Serum_84	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_84_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_84.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_84_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_85	C_Serum_85	Factor:eARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-C_Serum_85_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-C_Serum_85.mzML 20191022_Cer_SM_Human serum_set5_HJW-C_Serum_85_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_51	B_Serum_51	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_51_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_51.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_51_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_52	B_Serum_52	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_52_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_52.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_52_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_53	B_Serum_53	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_53_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_53.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_53_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_54	B_Serum_54	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_54_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_54.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_54_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_55	B_Serum_55	Factor:pARDS	Batch=5; RAW_FILE_NAME=20191022_PC,PE profiling_Human serum_set5_HJW-B_Serum_55_1_100.mzML 20191023_PLS_Human serum_Set5_HJW-B_Serum_55.mzML 20191022_Cer_SM_Human serum_set5_HJW-B_Serum_55_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_26	D_Serum_26	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_26_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_26.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_26_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_27	D_Serum_27	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_27_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_27.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_27_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_28	D_Serum_28	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_28_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_28.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_28_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_29	D_Serum_29	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_29_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_29.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_29_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	D_Serum_30	D_Serum_30	Factor:Control	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-D_Normal serum_30_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-D_Normal serum_30.mzML 20191025_Cer_SM_Human serum_set6_HJW-D_Normal serum_30_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_86	C_Serum_86	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_86_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_86.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_86_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_87	C_Serum_87	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_87_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_87.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_87_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_88	C_Serum_88	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_88_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_88.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_88_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_89	C_Serum_89	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_89_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_89.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_89_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	C_Serum_90	C_Serum_90	Factor:eARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-C_Serum_90_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-C_Serum_90.mzML 20191025_Cer_SM_Human serum_set6_HJW-C_Serum_90_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_56	B_Serum_56	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_56_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_56.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_56_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_57	B_Serum_57	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_57_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_57.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_57_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_58	B_Serum_58	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_58_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_58.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_58_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_59	B_Serum_59	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_59_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_59.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_59_1_5.mzML
SUBJECT_SAMPLE_FACTORS           	B_Serum_60	B_Serum_60	Factor:pARDS	Batch=6; RAW_FILE_NAME=20191025_PC,PE profiling_Human serum_set6_HJW_cell media-B_Serum_60_1_100.mzML 20191028_PLS_Human serum_Set6_HJW-B_Serum_60.mzML 20191025_Cer_SM_Human serum_set6_HJW-B_Serum_60_1_5.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	This study was approved by the Asan Institutional Review Board (IRB No.
CO:COLLECTION_SUMMARY            	2019-1017). The inclusion criteria for the cohort were as follows: adult
CO:COLLECTION_SUMMARY            	patients aged > 18 years, patients admitted to the medical intensive care unit
CO:COLLECTION_SUMMARY            	(ICU) and clinically diagnosed as sepsis according to the Sepsis-2 definition16,
CO:COLLECTION_SUMMARY            	and those enrolled within 48 hours of ICU admission. The patients' serum was
CO:COLLECTION_SUMMARY            	collected at the time of sepsis cohort enrollment. The healthy control registry
CO:COLLECTION_SUMMARY            	included healthy people who visited the Health Screening and Promotion Center at
CO:COLLECTION_SUMMARY            	Asan Medical Center. The diagnosis of direct ARDS and indirect ARDS was made
CO:COLLECTION_SUMMARY            	through a blind review by the two intensivists reaching the same judgment.Since
CO:COLLECTION_SUMMARY            	the eligible ARDS patients belonged to the sepsis cohort, the direct ARDS group
CO:COLLECTION_SUMMARY            	included pulmonary ARDS patients with pneumonia-induced sepsis, and the indirect
CO:COLLECTION_SUMMARY            	ARDS included extrapulmonary ARDS patients with non-pneumonia induced sepsis.
CO:SAMPLE_TYPE                   	Blood (serum)
CO:STORAGE_CONDITIONS            	-80℃
#TREATMENT
TR:TREATMENT_SUMMARY             	not available
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	50 μL human serum was mixed well, and 50 μL of internal standard solutions (50
SP:SAMPLEPREP_SUMMARY            	nM C17 ceramide for sphingolipid; 200 nM 18:0 D70 PC and 1 μM 16:0 D31-18:1 PE
SP:SAMPLEPREP_SUMMARY            	for plasmalogen and PC/PE profiling) were added. Metabolites were extracted from
SP:SAMPLEPREP_SUMMARY            	aqueous and organic phases by liquid-liquid extraction after the addition of
SP:SAMPLEPREP_SUMMARY            	chloroform and H2O. Nonpolar metabolites containing lipids were collected from
SP:SAMPLEPREP_SUMMARY            	the lower organic phase. The organic phases were dried under vacuum and stored
SP:SAMPLEPREP_SUMMARY            	at -20℃oC until further analysis. The dried matter was reconstituted with 50
SP:SAMPLEPREP_SUMMARY            	μL of MeOH prior to LC-MS/MS analysis.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	LC-MS/MS (MRM) for phospholipid
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Agilent 1290
CH:COLUMN_NAME                   	Agilent ZORBAX Eclipse Plus C18 (50 x 2.1mm,1.8um)
CH:SOLVENT_A                     	10 mM ammonium acetate in MeOH/isopropanol/H2O(900/50/50)
CH:SOLVENT_B                     	10 mM ammonium acetate in MeOH/isopropanol/H2O(940/50/10)
CH:FLOW_GRADIENT                 	isocratic condition of 60% B
CH:FLOW_RATE                     	400 µL/min
CH:COLUMN_TEMPERATURE            	30
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 5500 QTrap
MS:INSTRUMENT_TYPE               	QTRAP
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	Data analysis was performed using Analyst 1.5.2 software. Extracted ion
MS:MS_COMMENTS                   	chromatograms (EIC) corresponding to each metabolite were used for quantitation
MS:MS_COMMENTS                   	(MRM). The area under the curve of each EIC was normalized to that of the
MS:MS_COMMENTS                   	internal standard. For metabolites related to PC/PE profiling, the peak area
MS:MS_COMMENTS                   	ratio of each metabolite to that of the internal standard was used for a
MS:MS_COMMENTS                   	relative comparison. For plasmalogens, the calibration range was generally 0.1
MS:MS_COMMENTS                   	nM to 10 μM with R2>0.99
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	nM
MS_METABOLITE_DATA_START
Samples	D_Serum_1	D_Serum_2	D_Serum_3	D_Serum_4	D_Serum_5	D_Serum_6	D_Serum_7	D_Serum_8	D_Serum_9	D_Serum_10	D_Serum_11	D_Serum_12	D_Serum_13	D_Serum_14	D_Serum_15	D_Serum_16	D_Serum_17	D_Serum_18	D_Serum_19	D_Serum_20	D_Serum_21	D_Serum_22	D_Serum_23	D_Serum_24	D_Serum_25	D_Serum_26	D_Serum_27	D_Serum_28	D_Serum_29	D_Serum_30	C_Serum_61	C_Serum_62	C_Serum_63	C_Serum_64	C_Serum_65	C_Serum_66	C_Serum_67	C_Serum_68	C_Serum_69	C_Serum_70	C_Serum_71	C_Serum_72	C_Serum_73	C_Serum_74	C_Serum_75	C_Serum_76	C_Serum_77	C_Serum_78	C_Serum_79	C_Serum_80	C_Serum_81	C_Serum_82	C_Serum_83	C_Serum_84	C_Serum_85	C_Serum_86	C_Serum_87	C_Serum_88	C_Serum_89	C_Serum_90	B_Serum_31	B_Serum_32	B_Serum_33	B_Serum_34	B_Serum_35	B_Serum_36	B_Serum_37	B_Serum_38	B_Serum_39	B_Serum_40	B_Serum_41	B_Serum_42	B_Serum_43	B_Serum_44	B_Serum_45	B_Serum_46	B_Serum_47	B_Serum_48	B_Serum_49	B_Serum_50	B_Serum_51	B_Serum_52	B_Serum_53	B_Serum_54	B_Serum_55	B_Serum_56	B_Serum_57	B_Serum_58	B_Serum_59	B_Serum_60
Factors	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:Control	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:eARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS	Factor:pARDS
C18_Plasm_LPC	243	136	209	211	260	253	274	310	293	257	391	273	456	302	437	443	411	535	476	435	656	635	604	318	282	727	628	343	607	706	32.2	33.7	50.8	22.5	29	86.3	95.5	24	79.6	167	188	52.2	55.5	118	28	37.4	167	126	32.2	23.7	31.1	90.3	450	331	106	104	220	37.4	171	41.8	35.7	12.6	68.6	75.5	164	119	42.6	104	104	48.1	253	66	69.2	82.5	107	169	166	321	276	195	145	83.4	72.3	137	50.8	214	212	205	501	155
C18_Plasm_18_1_PC	276	212	260	204	164	281	176	236	140	306	373	338	458	248	252	192	211	213	328	226	481	500	221	183	124	178	401	164	286	480	302	118	397	88.1	130	216	271	81.6	183	143	315	193	195	199	111	93.7	284	185	105	84.1	98.5	242	386	132	133	208	284	215	133	141	232	187	140	74.8	200	106	131	124	124	89.7	291	161	295	311	183	174	379	352	183	221	119	74.4	207	214	41.1	132	181	189	141	326
C18_Plasm_22_6_PC	671	549	497	457	443	764	710	971	532	1100	885	915	1230	963	1350	687	1140	783	1020	788	1390	1450	889	843	497	726	998	581	808	1820	239	119	261	147	137	333	576	180	448	454	703	240	260	583	278	173	645	450	297	96.2	198	546	433	444	292	491	946	292	316	160	225	237	180	122	394	252	210	157	217	226	975	207	589	489	236	415	668	507	484	697	343	97.5	189	461	107	250	481	531	394	546
C18_Plasm_20_4_PC	942	635	574	779	777	869	753	757	572	1380	1560	891	1560	945	927	998	916	1200	1210	1020	1890	1820	1160	1060	691	1000	1710	1160	1550	2260	407	148	552	211	327	686	917	323	545	651	773	541	711	1080	466	401	1410	692	502	190	419	833	782	508	452	855	722	529	633	456	302	300	421	244	635	394	580	258	359	340	1420	781	768	880	559	832	1040	874	1200	681	519	252	473	1160	191	362	484	941	619	935
C18_Plasm_22_6_PE	11300	8780	6430	7480	7520	11600	7760	6520	7030	12900	18800	11100	18500	9280	18100	7680	12400	14800	12600	9880	13200	19400	9700	7080	6200	7740	10300	7210	9940	25000	10000	653	3540	2470	801	4350	9340	2110	7310	4820	6450	3050	1890	6260	3960	833	6510	4910	2190	1770	2100	3560	1770	3720	1980	3340	7830	3890	2600	1720	1550	4420	1820	1210	3610	1540	1750	1030	1550	3370	10600	2020	5300	4460	2500	3120	5590	3950	5790	5480	2340	637	1560	1970	976	2010	3790	3720	2960	3260
C18_Plasm_18_1_PE	376	255	288	297	340	708	347	167	272	689	1040	356	700	312	471	456	344	682	576	499	562	890	383	197	219	317	314	283	421	704	608	49.8	235	111	68.9	317	511	112	215	164	334	321	101	214	135	46.9	358	241	63.4	127	97.9	142	155	108	105	151	206	215	63.3	109	58.4	320	160	35	211	84.3	154	93.5	85.6	80.5	371	126	290	339	136	154	349	277	315	285	59.6	30.4	113	99.7	30.4	117	127	145	106	108
C18_Plasm_LPE	118	81.7	76.6	101	103	145	137	116	175	137	291	140	233	148	238	189	125	246	175	142	200	278	202	62.4	92.2	130	114	79	139	188	117	10.9	25.4	12.4	10.2	28.3	72.2	13.6	35.2	38.8	82.9	23.3	18.1	40.2	15.2	18.6	41.5	27.5	12.6	24.3	18.4	31.3	39	54.2	36.8	43.8	33.6	44.4	23.4	9.43	17.2	16.4	22.3	9.1	30.9	19.9	38.8	14.3	43.2	27.9	82.4	16.2	29.7	59.5	22.8	53	65.1	43.8	54.6	54.6	15.9	26.2	28.5	26	19.4	31.2	20.8	18	75	35
C18_Plasm_20_4_PE	8890	4210	4780	5870	8570	8630	5940	2870	4490	10500	18300	6080	14800	5930	8110	7160	7460	12700	9380	9990	12700	18300	6980	4400	4690	7000	9730	6400	6950	18200	4430	222	2100	1070	289	2850	7610	1430	2930	2830	2630	1140	1290	2210	1270	304	2560	2270	744	900	1610	1900	1030	2010	1150	2430	2050	2590	1280	1960	670	1790	1500	420	1510	639	1630	285	1000	1450	6400	1740	1280	3400	1890	2560	2150	2750	2270	1730	1030	405	1580	1260	526	1390	1120	1730	2110	1610
LPC_16_0	78.5	39.5	72.5	102.2	93.1	62.8	48.6	48	130.4	25.2	53.4	32.6	78.1	31.7	61.6	154.3	68.6	81.1	92.9	69.3	62.3	37.6	138.5	46.7	65.2	78.7	55.8	141.3	61	31.8	22.7	31.9	34.1	24	5	7	17.7	3.6	18.7	63.8	26.8	18.7	12	17	4.4	23	43.2	7	8.8	10.9	3.8	4.7	49.5	61.4	28.8	11.8	9.9	5.3	5.7	15.8	17.5	8	12.5	75.3	112.5	51.2	39.8	18.2	35.4	36.6	28.6	24.7	20.5	17.2	23.9	35.4	41.6	45.4	65	53.6	25.7	14.9	63.9	41.1	25.3	40.5	33.1	32.2	30.7	16.9
LPC_17_6	12.2	7.1	12.3	15.9	14.2	9.6	7.7	7.4	20.4	3.6	8.3	5.1	11.7	5.2	9.4	21.5	9.4	11.4	12.3	10.6	12.6	7.3	24.5	7.9	11.3	10.9	8.3	21.6	8.6	4.2	3.8	5	3.9	4.3	0.6	1.3	3.1	0.5	2.8	9.7	4.3	3	2.1	2.8	0.7	3.9	5.7	1.4	1.2	1.6	0.4	0.9	7.8	10.9	4.9	1.8	1.3	0.7	0.5	2.3	3.8	1.5	2.1	11.6	18.3	9.9	6.3	3.1	5.8	6.1	4.7	3.9	3.5	2.6	4	6.2	6.7	6.4	9.1	7.3	4.6	3.2	11.1	8	5.4	6.4	5.7	4.7	4.1	3.5
LPC_18_2	23.7	5.9	17.3	18.8	13.3	14.4	11.2	9	19.6	5.4	10.4	8.3	13.1	5.9	7.4	23.6	10.5	14.3	17.8	17.6	16.7	8.3	23.4	8.5	23	29.7	12.3	29.8	8.6	7.2	4.9	8.3	3	1.8	0.8	1.4	3.1	2.2	2.5	3.3	2.6	22.3	2.8	1.2	4.2	2.6	7.2	1.5	1.7	2.3	0.9	0.6	3.6	9.8	13.7	8.2	8.4	1	1.6	27.5	4.4	4.5	1.4	5.2	33.6	4.6	6.9	5.1	4.5	12.3	6.9	4.3	14	3.2	2.4	5.5	13.7	15.8	5.6	7.5	2	1.8	9.2	10.8	4.5	3.9	2.9	5	3.1	4.7
LPC_18_1	20.2	7.9	18.6	20.4	18.8	13.3	13.1	11.6	23.6	6.4	12.9	6.8	17	6.8	8.6	29.9	10.9	16.5	19.1	14.5	14.4	8.7	27.3	8	15	32.1	12	27.3	19.4	6.8	5.3	8.9	5.9	4.1	1.7	3.9	4.3	2.3	5	8	5.1	19.6	3.8	3.5	3.6	4.3	11.1	1.9	1.8	3.2	1.1	1.7	9.1	9.5	14.4	8.5	9.4	1.9	2.6	22	6.4	5.1	3	13	27.9	8.1	9	9.2	7.8	11.6	7.2	5.6	11.6	4.3	4.7	7.7	12.2	16.5	10	8.5	3.3	3.8	12	11.5	5.5	6.9	5.2	7.4	4.9	6.2
LPC_18_0	35.4	15.5	36.5	41.1	36.5	28.3	26	20.5	47.2	9.9	17.9	13.5	27.8	15.6	25.2	59.9	29.8	30.6	46.2	31.3	31.2	19.3	49.3	16.9	26.6	44.4	22.6	53.8	24.2	16.8	8	10.5	12.4	9.6	2.2	3.4	8.1	1.7	10.2	16.2	10.7	8.6	4.1	5.6	2.3	10.1	12.4	5	4.6	5.3	2.1	2.1	14.8	19.8	13.2	6	4.8	2.8	2.3	9.7	8.9	4.5	4.9	39.2	40.4	18.4	16.1	7.8	10.4	17.1	11.1	7.9	8.4	4.5	7.6	14.4	13.3	14.5	21.8	16.4	11.2	9.2	22.8	15.5	11.5	12.7	15.5	12.5	14.3	7.4
LPC_19_6	7	2.7	5.6	7.2	6.9	4.9	4.6	3.3	9	1.7	3.1	2.5	4.6	2.7	4.8	10	6.1	5	7.7	5.2	6.1	3.6	8.8	3.3	5	6.4	3.4	9.5	3.5	2.7	2.2	1.4	2.1	1.7	0.4	0.6	1.4	0.4	1.6	3.1	2.1	0.8	0.6	1.1	0.5	2	2	0.9	0.7	1	0.3	0.4	3.3	3.2	2.2	0.6	0.6	0.5	0.6	0.8	1.6	0.6	0.7	7.7	8.8	3.1	2.4	1.6	1.8	2.7	1.9	1.3	1.4	0.7	1.3	2.3	1.8	2.6	3.9	2.3	2.4	1.2	4.5	3	3.1	1.9	2.3	2	2.6	1
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	HMDB_ID	KEGG_ID
C18_Plasm_LPC	HMDB0013122
C18_Plasm_18_1_PC	HMDB0289587
C18_Plasm_22_6_PC	HMDB0289611
C18_Plasm_20_4_PC	HMDB0289535
C18_Plasm_22_6_PE	HMDB0011394
C18_Plasm_18_1_PE	HMDB0011375
C18_Plasm_LPE	HMDB0240598
C18_Plasm_20_4_PE	HMDB0005779
LPC_16_0		C04230
LPC_17_6		C04231
LPC_18_2		C04232
LPC_18_1		C04233
LPC_18_0		C04234
LPC_19_6		C04235
METABOLITES_END
#END