#METABOLOMICS WORKBENCH iuk41_20240328_121846 DATATRACK_ID:4749 STUDY_ID:ST003149 ANALYSIS_ID:AN005167 PROJECT_ID:PR001958
VERSION             	1
CREATED_ON             	March 28, 2024, 4:00 pm
#PROJECT
PR:PROJECT_TITLE                 	Impact of early-life exposure to a potent aryl hydrocarbon receptor ligand on
PR:PROJECT_TITLE                 	gut microbiota and host glucose homeostasis in C57BL/6J male mice
PR:PROJECT_SUMMARY               	This study aimed to explore the association between early-life exposure to a
PR:PROJECT_SUMMARY               	potent aryl hydrocarbon receptor (AHR) agonist and persistent disruptions in the
PR:PROJECT_SUMMARY               	microbiota, leading to impaired metabolic homeostasis later in life. This study
PR:PROJECT_SUMMARY               	utilized metagenomics, NMR- and mass spectrometry-based metabolomics, and
PR:PROJECT_SUMMARY               	biochemical assays to analyze the gut microbiome composition and function, as
PR:PROJECT_SUMMARY               	well as the physiological and metabolic effects of early-life exposure to
PR:PROJECT_SUMMARY               	2,3,7,8-tetrachlorodibenzofuran (TCDF) in conventional, germ-free (GF), and
PR:PROJECT_SUMMARY               	Ahr-null mice. The impact of TCDF on Akkermansia muciniphila (A. muciniphila) in
PR:PROJECT_SUMMARY               	vitro was assessed using optical density (OD 600), flow cytometry,
PR:PROJECT_SUMMARY               	transcriptomics, and mass spectrometry-based metabolomics.
PR:INSTITUTE                     	Penn State University
PR:DEPARTMENT                    	Department of Veterinary and Biomedical Sciences
PR:LAST_NAME                     	Koo
PR:FIRST_NAME                    	Imhoi
PR:ADDRESS                       	307B Life Science Building
PR:EMAIL                         	iuk41@psu.edu
PR:PHONE                         	18148657803
#STUDY
ST:STUDY_TITLE                   	Impact of early-life exposure to a potent aryl hydrocarbon receptor ligand on
ST:STUDY_TITLE                   	gut microbiota and host glucose homeostasis in C57BL/6J male mice (Part I)
ST:STUDY_SUMMARY                 	This study aimed to explore the association between early-life exposure to a
ST:STUDY_SUMMARY                 	potent aryl hydrocarbon receptor (AHR) agonist and persistent disruptions in the
ST:STUDY_SUMMARY                 	microbiota, leading to impaired metabolic homeostasis later in life. This study
ST:STUDY_SUMMARY                 	utilized metagenomics, NMR- and mass spectrometry-based metabolomics, and
ST:STUDY_SUMMARY                 	biochemical assays to analyze the gut microbiome composition and function, as
ST:STUDY_SUMMARY                 	well as the physiological and metabolic effects of early-life exposure to
ST:STUDY_SUMMARY                 	2,3,7,8-tetrachlorodibenzofuran (TCDF) in conventional, germ-free (GF), and
ST:STUDY_SUMMARY                 	Ahr-null mice. The impact of TCDF on Akkermansia muciniphila (A. muciniphila) in
ST:STUDY_SUMMARY                 	vitro was assessed using optical density (OD 600), flow cytometry,
ST:STUDY_SUMMARY                 	transcriptomics, and mass spectrometry-based metabolomics.
ST:INSTITUTE                     	Penn State University
ST:DEPARTMENT                    	Department of Veterinary and Biomedical Sciences
ST:LAST_NAME                     	Koo
ST:FIRST_NAME                    	Imhoi
ST:ADDRESS                       	307B Life Science Building
ST:EMAIL                         	iuk41@psu.edu
ST:PHONE                         	8148107425
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
SU:AGE_OR_AGE_RANGE              	4 weeks to 5 months
SU:GENDER                        	Male
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__1	AHR.KO.liver.lipid.with.TCDF__1	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.1.fid
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__2	AHR.KO.liver.lipid.with.TCDF__2	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.2.fid
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__3	AHR.KO.liver.lipid.with.TCDF__3	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.3.fid
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__4	AHR.KO.liver.lipid.with.TCDF__4	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.4.fid
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__5	AHR.KO.liver.lipid.with.TCDF__5	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.5.fid
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__6	AHR.KO.liver.lipid.with.TCDF__6	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.6.fid
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__7	AHR.KO.liver.lipid.with.TCDF__7	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.7.fid
SUBJECT_SAMPLE_FACTORS           	AHR.KO.liver.lipid.with.TCDF__8	AHR.KO.liver.lipid.with.TCDF__8	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=1.AHR KO mice liver lipid with TCDF.8.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__1	GF.cecal.content_Akkermansia__1	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.1.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__2	GF.cecal.content_Akkermansia__2	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.2.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__3	GF.cecal.content_Akkermansia__3	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.3.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__4	GF.cecal.content_Akkermansia__4	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.4.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__5	GF.cecal.content_Akkermansia__5	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.5.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__6	GF.cecal.content_Akkermansia__6	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.6.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__7	GF.cecal.content_Akkermansia__7	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.7.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__8	GF.cecal.content_Akkermansia__8	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:ABX water	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.8.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__9	GF.cecal.content_Akkermansia__9	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:ABX water	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.9.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__10	GF.cecal.content_Akkermansia__10	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:ABX water	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.10.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__11	GF.cecal.content_Akkermansia__11	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.11.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_Akkermansia__12	GF.cecal.content_Akkermansia__12	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	RAW_FILE_NAME=2.GF mice cecal content_Akkermansia transplantation.12.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__1	GF.cecal.content_cecal.bacteria__1	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.1.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__2	GF.cecal.content_cecal.bacteria__2	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.2.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__3	GF.cecal.content_cecal.bacteria__3	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.3.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__4	GF.cecal.content_cecal.bacteria__4	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.4.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__6	GF.cecal.content_cecal.bacteria__6	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.6.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__7	GF.cecal.content_cecal.bacteria__7	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.7.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__8	GF.cecal.content_cecal.bacteria__8	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.8.fid
SUBJECT_SAMPLE_FACTORS           	GF.cecal.content_cecal.bacteria__9	GF.cecal.content_cecal.bacteria__9	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=3.GF mice cecal content_cecal bacteria transplantantion.9.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__1	GF.liver.lipid._cecal.bacteria__1	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.1.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__2	GF.liver.lipid._cecal.bacteria__2	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.2.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__3	GF.liver.lipid._cecal.bacteria__3	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.3.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__4	GF.liver.lipid._cecal.bacteria__4	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.4.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__5	GF.liver.lipid._cecal.bacteria__5	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.5.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__6	GF.liver.lipid._cecal.bacteria__6	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.6.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__7	GF.liver.lipid._cecal.bacteria__7	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.7.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__8	GF.liver.lipid._cecal.bacteria__8	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.8.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__9	GF.liver.lipid._cecal.bacteria__9	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.9.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid._cecal.bacteria__10	GF.liver.lipid._cecal.bacteria__10	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	RAW_FILE_NAME=4.GF mice liver lipid _cecal bacteria transplantantion.10.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__1	GF.liver.lipid.with.TCDF__1	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.1.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__2	GF.liver.lipid.with.TCDF__2	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.2.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__3	GF.liver.lipid.with.TCDF__3	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.3.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__4	GF.liver.lipid.with.TCDF__4	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.4.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__5	GF.liver.lipid.with.TCDF__5	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.5.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__6	GF.liver.lipid.with.TCDF__6	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.6.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__7	GF.liver.lipid.with.TCDF__7	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.7.fid
SUBJECT_SAMPLE_FACTORS           	GF.liver.lipid.with.TCDF__8	GF.liver.lipid.with.TCDF__8	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=5.GF mice liver lipid with TCDF.8.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__1	cecal.content.with.TCDF_long__1	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=7.mice cecal content with TCDF_long.1.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__2	cecal.content.with.TCDF_long__2	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=7.mice cecal content with TCDF_long.2.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__3	cecal.content.with.TCDF_long__3	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=7.mice cecal content with TCDF_long.3.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__4	cecal.content.with.TCDF_long__4	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=7.mice cecal content with TCDF_long.4.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__5	cecal.content.with.TCDF_long__5	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=7.mice cecal content with TCDF_long.5.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__6	cecal.content.with.TCDF_long__6	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=7.mice cecal content with TCDF_long.6.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__7	cecal.content.with.TCDF_long__7	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=7.mice cecal content with TCDF_long.7.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__8	cecal.content.with.TCDF_long__8	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=7.mice cecal content with TCDF_long.8.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__9	cecal.content.with.TCDF_long__9	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=7.mice cecal content with TCDF_long.9.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__10	cecal.content.with.TCDF_long__10	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=7.mice cecal content with TCDF_long.10.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__11	cecal.content.with.TCDF_long__11	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=7.mice cecal content with TCDF_long.11.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_long__12	cecal.content.with.TCDF_long__12	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=7.mice cecal content with TCDF_long.12.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__1	cecal.content.with.TCDF_short__1	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=8.mice cecal content with TCDF_short.1.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__2	cecal.content.with.TCDF_short__2	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=8.mice cecal content with TCDF_short.2.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__3	cecal.content.with.TCDF_short__3	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=8.mice cecal content with TCDF_short.3.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__4	cecal.content.with.TCDF_short__4	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=8.mice cecal content with TCDF_short.4.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__5	cecal.content.with.TCDF_short__5	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=8.mice cecal content with TCDF_short.5.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__6	cecal.content.with.TCDF_short__6	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=8.mice cecal content with TCDF_short.6.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__7	cecal.content.with.TCDF_short__7	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=8.mice cecal content with TCDF_short.7.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__8	cecal.content.with.TCDF_short__8	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=8.mice cecal content with TCDF_short.8.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__9	cecal.content.with.TCDF_short__9	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=8.mice cecal content with TCDF_short.9.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__10	cecal.content.with.TCDF_short__10	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=8.mice cecal content with TCDF_short.10.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__11	cecal.content.with.TCDF_short__11	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=8.mice cecal content with TCDF_short.11.fid
SUBJECT_SAMPLE_FACTORS           	cecal.content.with.TCDF_short__12	cecal.content.with.TCDF_short__12	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=8.mice cecal content with TCDF_short.12.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__201	liver.lipid.with.TCDF_long__201	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.201.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__202	liver.lipid.with.TCDF_long__202	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.202.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__203	liver.lipid.with.TCDF_long__203	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.203.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__204	liver.lipid.with.TCDF_long__204	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.204.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__205	liver.lipid.with.TCDF_long__205	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.205.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__206	liver.lipid.with.TCDF_long__206	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.206.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__207	liver.lipid.with.TCDF_long__207	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.207.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__208	liver.lipid.with.TCDF_long__208	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.208.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__209	liver.lipid.with.TCDF_long__209	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.209.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__210	liver.lipid.with.TCDF_long__210	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.210.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__211	liver.lipid.with.TCDF_long__211	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.211.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_long__212	liver.lipid.with.TCDF_long__212	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=9.mice liver lipid with TCDF_long.212.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__101	liver.lipid.with.TCDF_short__101	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.101.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__102	liver.lipid.with.TCDF_short__102	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.102.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__103	liver.lipid.with.TCDF_short__103	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.103.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__104	liver.lipid.with.TCDF_short__104	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.104.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__105	liver.lipid.with.TCDF_short__105	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.105.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__106	liver.lipid.with.TCDF_short__106	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.106.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__107	liver.lipid.with.TCDF_short__107	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.107.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__108	liver.lipid.with.TCDF_short__108	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.108.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__109	liver.lipid.with.TCDF_short__109	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.109.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__110	liver.lipid.with.TCDF_short__110	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.110.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__111	liver.lipid.with.TCDF_short__111	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.111.fid
SUBJECT_SAMPLE_FACTORS           	liver.lipid.with.TCDF_short__112	liver.lipid.with.TCDF_short__112	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=10.mice liver lipid with TCDF_short.112.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__1	liver.with.TCDF_.long__1	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=11.mice liver with TCDF_ long.1.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__2	liver.with.TCDF_.long__2	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=11.mice liver with TCDF_ long.2.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__3	liver.with.TCDF_.long__3	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=11.mice liver with TCDF_ long.3.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__4	liver.with.TCDF_.long__4	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=11.mice liver with TCDF_ long.4.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__5	liver.with.TCDF_.long__5	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=11.mice liver with TCDF_ long.5.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__6	liver.with.TCDF_.long__6	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=11.mice liver with TCDF_ long.6.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__7	liver.with.TCDF_.long__7	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=11.mice liver with TCDF_ long.7.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__8	liver.with.TCDF_.long__8	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=11.mice liver with TCDF_ long.8.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__9	liver.with.TCDF_.long__9	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=11.mice liver with TCDF_ long.9.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__10	liver.with.TCDF_.long__10	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=11.mice liver with TCDF_ long.10.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__11	liver.with.TCDF_.long__11	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=11.mice liver with TCDF_ long.11.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_.long__12	liver.with.TCDF_.long__12	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=11.mice liver with TCDF_ long.12.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__1	liver.with.TCDF_short__1	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=12.mice liver with TCDF_short.1.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__2	liver.with.TCDF_short__2	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=12.mice liver with TCDF_short.2.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__3	liver.with.TCDF_short__3	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=12.mice liver with TCDF_short.3.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__4	liver.with.TCDF_short__4	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=12.mice liver with TCDF_short.4.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__5	liver.with.TCDF_short__5	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=12.mice liver with TCDF_short.5.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__6	liver.with.TCDF_short__6	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=12.mice liver with TCDF_short.6.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__7	liver.with.TCDF_short__7	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=12.mice liver with TCDF_short.7.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__8	liver.with.TCDF_short__8	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=12.mice liver with TCDF_short.8.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__9	liver.with.TCDF_short__9	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=12.mice liver with TCDF_short.9.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__10	liver.with.TCDF_short__10	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=12.mice liver with TCDF_short.10.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__11	liver.with.TCDF_short__11	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=12.mice liver with TCDF_short.11.fid
SUBJECT_SAMPLE_FACTORS           	liver.with.TCDF_short__12	liver.with.TCDF_short__12	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=12.mice liver with TCDF_short.12.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__1	urine.with.TCDF_long__1	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=13.mice urine with TCDF_long.1.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__2	urine.with.TCDF_long__2	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=13.mice urine with TCDF_long.2.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__3	urine.with.TCDF_long__3	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=13.mice urine with TCDF_long.3.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__4	urine.with.TCDF_long__4	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=13.mice urine with TCDF_long.4.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__5	urine.with.TCDF_long__5	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=13.mice urine with TCDF_long.5.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__6	urine.with.TCDF_long__6	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=13.mice urine with TCDF_long.6.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__7	urine.with.TCDF_long__7	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=13.mice urine with TCDF_long.7.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__8	urine.with.TCDF_long__8	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=13.mice urine with TCDF_long.8.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__9	urine.with.TCDF_long__9	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=13.mice urine with TCDF_long.9.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__10	urine.with.TCDF_long__10	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=13.mice urine with TCDF_long.10.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__11	urine.with.TCDF_long__11	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=13.mice urine with TCDF_long.11.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_long__12	urine.with.TCDF_long__12	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=13.mice urine with TCDF_long.12.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__1	urine.with.TCDF_short__1	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=14.mice urine with TCDF_short.1.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__2	urine.with.TCDF_short__2	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=14.mice urine with TCDF_short.2.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__3	urine.with.TCDF_short__3	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=14.mice urine with TCDF_short.3.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__4	urine.with.TCDF_short__4	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=14.mice urine with TCDF_short.4.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__5	urine.with.TCDF_short__5	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=14.mice urine with TCDF_short.5.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__6	urine.with.TCDF_short__6	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	RAW_FILE_NAME=14.mice urine with TCDF_short.6.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__7	urine.with.TCDF_short__7	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=14.mice urine with TCDF_short.7.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__8	urine.with.TCDF_short__8	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=14.mice urine with TCDF_short.8.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__9	urine.with.TCDF_short__9	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=14.mice urine with TCDF_short.9.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__10	urine.with.TCDF_short__10	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=14.mice urine with TCDF_short.10.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__11	urine.with.TCDF_short__11	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=14.mice urine with TCDF_short.11.fid
SUBJECT_SAMPLE_FACTORS           	urine.with.TCDF_short__12	urine.with.TCDF_short__12	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	RAW_FILE_NAME=14.mice urine with TCDF_short.12.fid
#COLLECTION
CO:COLLECTION_SUMMARY            	Blood collection via cardiac puncture was performed post-sacrifice, and serum
CO:COLLECTION_SUMMARY            	samples were obtained by centrifugation (5,000 g, 4°C) for 5 min using BD
CO:COLLECTION_SUMMARY            	Microtainer Boold Collection Tubes (BD, Franklin Lakes, NJ). Liver, cecal
CO:COLLECTION_SUMMARY            	content, adipose, and intestinal tissue samples were collected immediately after
CO:COLLECTION_SUMMARY            	sacrifice by carbon dioxide asphyxiation and kept at -80°C. Urine and feces
CO:COLLECTION_SUMMARY            	were collected using separate cages before sacrifice and kept at -80°C.
CO:SAMPLE_TYPE                   	Liver
#TREATMENT
TR:TREATMENT_SUMMARY             	1. After feed training, mice were fed pills containing TCDF (dissolved in
TR:TREATMENT_SUMMARY             	acetone) or acetone alone as vehicle, and one pill uniformly contained 0.46 µg
TR:TREATMENT_SUMMARY             	TCDF (24 µg/kg as final dose). Mice were housed singly in an empty cage and
TR:TREATMENT_SUMMARY             	monitored to ensure the pill was consumed in the morning for 5 days. 2. TCDF (24
TR:TREATMENT_SUMMARY             	µg/kg) or corn oil as vehicle were administered to age-matched male GF and
TR:TREATMENT_SUMMARY             	Ahr-/- mice by oral gavage once daily for five days (n = 4 per group). 3.
TR:TREATMENT_SUMMARY             	Four-week-old male GF C57BL/6J mice were orally gavaged with 100 µL of cecal
TR:TREATMENT_SUMMARY             	suspension (100 mg in 1 mL sterile BHI CHV media) from vehicle or TCDF treated
TR:TREATMENT_SUMMARY             	mice in long-duration model. 4. A. muciniphila was administered to GF mice by
TR:TREATMENT_SUMMARY             	oral gavage at one dose 107 CFU/0.1 mL suspended in sterile BHI CHV media
TR:TREATMENT_SUMMARY             	containing an end concentration of glycerol (15% vol/vol).
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Each plasma sample (200 μL) was mixed with 400 μL of saline solution
SP:SAMPLEPREP_SUMMARY            	(containing 75% D2O, 0.9% NaCl, 0.04% NaN3) and transferred into 5 mm NMR tubes
SP:SAMPLEPREP_SUMMARY            	for NMR analysis. For preparation of urine samples, 550 μL urine was blended
SP:SAMPLEPREP_SUMMARY            	with 55 μL of phosphate buffer (K2HPO4/NaH2PO4, 1.5 M, pH 7.4, 100% D2O)
SP:SAMPLEPREP_SUMMARY            	containing 0.01% TSP for chemical shift reference (δ0.00). After centrifugation
SP:SAMPLEPREP_SUMMARY            	(11 180 ×g, 4 °C) for 10 min, 550 μL supernatant was transferred into 5 mm
SP:SAMPLEPREP_SUMMARY            	NMR tubes for NMR analysis. Each liver tissue sample (55 ± 5 mg) was extracted
SP:SAMPLEPREP_SUMMARY            	three times with 600 μL of methanol/H2O (2:1) using a Qiagen tissue-lyzer.
SP:SAMPLEPREP_SUMMARY            	Three resultant supernatants were combined and subjected to centrifugation
SP:SAMPLEPREP_SUMMARY            	(16 099 ×g, 4 °C, 10 min). After removing methanol in vacuo, the resultant
SP:SAMPLEPREP_SUMMARY            	supernatant was lyophilized, weighed, and reconstituted into 600 μL phosphate
SP:SAMPLEPREP_SUMMARY            	buffer (0.1 M, K2HPO4/NaH2PO4, pH 7.4) containing 0.005% TSP, 50% D2O and 0.01%
SP:SAMPLEPREP_SUMMARY            	NaN3. After final centrifugation (16 099 ×g, 4 °C, 10 min), each supernatant
SP:SAMPLEPREP_SUMMARY            	(550 μL) was transferred into a 5 mm NMR tube for NMR analysis. Each fecal
SP:SAMPLEPREP_SUMMARY            	sample (55 ± 5 mg) were extracted twice with 500 μL phosphate buffer (0.1 M,
SP:SAMPLEPREP_SUMMARY            	K2HPO4/NaH2PO4, pH 7.4) containing 0.005% TSP, 30% D2O and 0.01% NaN3. After
SP:SAMPLEPREP_SUMMARY            	centrifugation (16 099 ×g, 4 °C, 10 min), 600 μL combined supernatants were
SP:SAMPLEPREP_SUMMARY            	transferred into 5 mm NMR tubes for NMR analysis. For liver lipid
SP:SAMPLEPREP_SUMMARY            	quantification, 50 mg of liver tissue was homogenized in 1 mL pre-cooled
SP:SAMPLEPREP_SUMMARY            	chloroform/methanol mix [1:1 (v/v)], followed by adding 296 µL water. After
SP:SAMPLEPREP_SUMMARY            	centrifugation (10,000 g, 4°C) for 10 min, the lower phase was dried in a
SP:SAMPLEPREP_SUMMARY            	vacuum and reconstituted in 600 µL of deuterated chloroform containing 0.03%
SP:SAMPLEPREP_SUMMARY            	(v/v) tetramethylsilane (TMS).
#ANALYSIS
AN:ANALYSIS_TYPE                 	NMR
#NMR
NM:INSTRUMENT_NAME               	Bruker Avance NEO 600 MHz
NM:INSTRUMENT_TYPE               	FT-NMR
NM:NMR_EXPERIMENT_TYPE           	1D-1H
NM:SPECTROMETER_FREQUENCY        	600 MHz
#NMR_METABOLITE_DATA
NMR_METABOLITE_DATA:UNITS	µmol/g
NMR_METABOLITE_DATA_START
Samples	liver.with.TCDF_short__1	liver.with.TCDF_short__2	liver.with.TCDF_short__3	liver.with.TCDF_short__4	liver.with.TCDF_short__5	liver.with.TCDF_short__6	liver.with.TCDF_short__7	liver.with.TCDF_short__8	liver.with.TCDF_short__9	liver.with.TCDF_short__10	liver.with.TCDF_short__11	liver.with.TCDF_short__12	liver.with.TCDF_.long__1	liver.with.TCDF_.long__2	liver.with.TCDF_.long__3	liver.with.TCDF_.long__4	liver.with.TCDF_.long__5	liver.with.TCDF_.long__6	liver.with.TCDF_.long__7	liver.with.TCDF_.long__8	liver.with.TCDF_.long__9	liver.with.TCDF_.long__10	liver.with.TCDF_.long__11	liver.with.TCDF_.long__12	liver.lipid.with.TCDF_short__101	liver.lipid.with.TCDF_short__102	liver.lipid.with.TCDF_short__103	liver.lipid.with.TCDF_short__104	liver.lipid.with.TCDF_short__105	liver.lipid.with.TCDF_short__106	liver.lipid.with.TCDF_short__107	liver.lipid.with.TCDF_short__108	liver.lipid.with.TCDF_short__109	liver.lipid.with.TCDF_short__110	liver.lipid.with.TCDF_short__111	liver.lipid.with.TCDF_short__112	liver.lipid.with.TCDF_long__201	liver.lipid.with.TCDF_long__202	liver.lipid.with.TCDF_long__203	liver.lipid.with.TCDF_long__204	liver.lipid.with.TCDF_long__205	liver.lipid.with.TCDF_long__206	liver.lipid.with.TCDF_long__207	liver.lipid.with.TCDF_long__208	liver.lipid.with.TCDF_long__209	liver.lipid.with.TCDF_long__210	liver.lipid.with.TCDF_long__211	liver.lipid.with.TCDF_long__212	AHR.KO.liver.lipid.with.TCDF__1	AHR.KO.liver.lipid.with.TCDF__2	AHR.KO.liver.lipid.with.TCDF__3	AHR.KO.liver.lipid.with.TCDF__7	AHR.KO.liver.lipid.with.TCDF__4	AHR.KO.liver.lipid.with.TCDF__5	AHR.KO.liver.lipid.with.TCDF__6	AHR.KO.liver.lipid.with.TCDF__8	cecal.content.with.TCDF_short__1	cecal.content.with.TCDF_short__2	cecal.content.with.TCDF_short__3	cecal.content.with.TCDF_short__4	cecal.content.with.TCDF_short__5	cecal.content.with.TCDF_short__6	cecal.content.with.TCDF_short__7	cecal.content.with.TCDF_short__8	cecal.content.with.TCDF_short__9	cecal.content.with.TCDF_short__10	cecal.content.with.TCDF_short__11	cecal.content.with.TCDF_short__12	cecal.content.with.TCDF_long__1	cecal.content.with.TCDF_long__2	cecal.content.with.TCDF_long__3	cecal.content.with.TCDF_long__4	cecal.content.with.TCDF_long__5	cecal.content.with.TCDF_long__6	cecal.content.with.TCDF_long__7	cecal.content.with.TCDF_long__8	cecal.content.with.TCDF_long__9	cecal.content.with.TCDF_long__10	cecal.content.with.TCDF_long__11	cecal.content.with.TCDF_long__12	GF.cecal.content_cecal.bacteria__1	GF.cecal.content_cecal.bacteria__2	GF.cecal.content_cecal.bacteria__3	GF.cecal.content_cecal.bacteria__4	GF.cecal.content_cecal.bacteria__6	GF.cecal.content_cecal.bacteria__7	GF.cecal.content_cecal.bacteria__8	GF.cecal.content_cecal.bacteria__9	GF.cecal.content_Akkermansia__6	GF.cecal.content_Akkermansia__7	GF.cecal.content_Akkermansia__11	GF.cecal.content_Akkermansia__12	GF.cecal.content_Akkermansia__8	GF.cecal.content_Akkermansia__9	GF.cecal.content_Akkermansia__10	GF.cecal.content_Akkermansia__1	GF.cecal.content_Akkermansia__2	GF.cecal.content_Akkermansia__3	GF.cecal.content_Akkermansia__4	GF.cecal.content_Akkermansia__5	GF.liver.lipid.with.TCDF__1	GF.liver.lipid.with.TCDF__2	GF.liver.lipid.with.TCDF__3	GF.liver.lipid.with.TCDF__4	GF.liver.lipid.with.TCDF__5	GF.liver.lipid.with.TCDF__6	GF.liver.lipid.with.TCDF__7	GF.liver.lipid.with.TCDF__8	urine.with.TCDF_short__1	urine.with.TCDF_short__2	urine.with.TCDF_short__3	urine.with.TCDF_short__4	urine.with.TCDF_short__5	urine.with.TCDF_short__6	urine.with.TCDF_short__7	urine.with.TCDF_short__8	urine.with.TCDF_short__9	urine.with.TCDF_short__10	urine.with.TCDF_short__11	urine.with.TCDF_short__12	urine.with.TCDF_long__1	urine.with.TCDF_long__2	urine.with.TCDF_long__3	urine.with.TCDF_long__4	urine.with.TCDF_long__5	urine.with.TCDF_long__6	urine.with.TCDF_long__7	urine.with.TCDF_long__8	urine.with.TCDF_long__9	urine.with.TCDF_long__10	urine.with.TCDF_long__11	urine.with.TCDF_long__12	GF.liver.lipid._cecal.bacteria__1	GF.liver.lipid._cecal.bacteria__2	GF.liver.lipid._cecal.bacteria__3	GF.liver.lipid._cecal.bacteria__4	GF.liver.lipid._cecal.bacteria__5	GF.liver.lipid._cecal.bacteria__6	GF.liver.lipid._cecal.bacteria__7	GF.liver.lipid._cecal.bacteria__8	GF.liver.lipid._cecal.bacteria__9	GF.liver.lipid._cecal.bacteria__10
Factors	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:Ahr-/- C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia +ABX water	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:ABX water	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:ABX water	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:ABX water	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	Sample source:cecal content | Genotype:GF C57BL/6J mice | Treatment:Akkermansia	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:vehicle	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:vehicle	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:urine | Genotype:WT C57BL/6J mice | Treatment:TCDF	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from vehicle group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group	Sample source:liver | Genotype:GF C57BL/6J mice | Treatment:cecal gavage from TCDF group
Glucose	66.02902	75.79344	70.41737	63.63052	85.19608	76.70708	69.56393	73.12726	69.72163	74.73473	62.46688	70.54906	103.0413	101.0058	134.6952	115.9444	151.0738	141.1366	123.8619	121.5149	126.8191	144.8771	135.6114	132.9753	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	30.33618	37.2586	38.40408	40.2208	39.71111	78.7489	47.77667	81.01283	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Glycogen	19.94113	26.85743	25.9732	23.81134	39.47917	30.93883	32.27313	32.78453	34.85019	33.85168	31.98295	31.38004	55.77097	56.48978	57.83388	47.33013	52.43069	50.39642	63.96238	57.32349	78.73663	62.00393	55.74141	58.87782	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	8.700958	21.83558	7.072365	17.41225	7.642695	29.69382	5.76027	21.7857	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
UDP-glucose	0.4109	0.289775	0.3819413	0.2699497	0.2186186	0.2668992	0.3642009	0.4043367	0.4454258	0.4413837	0.3587001	0.4259163	0.1308585	0.1553957	0.1837168	0.1338053	0.2850325	0.2304951	0.2511628	0.319604	0.3490446	0.4271186	0.5128571	0.4191781	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.1394656	0.301875	0.3200716	0.3232	0.4854348	0.3277002	0.5966492	0.4566667	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
TC	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	7.023964	9.338853	8.173699	8.061214	8.1494325	6.168451	10.35686	11.94655	9.461932	9.507602	9.304702	11.01635	6.576452	5.964225	8.211788	7.032209	8.194062	7.767	9.368967	7.253826	8.868746	8.43811	7.415814	7.915371	9.491859	10.08946	10.39166	7.634554	10.48966	10.53121	10.01207	10.3358	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	9.113708	9.532438	8.471268	9.101681	8.50759	10.30199	8.801509	9.392556	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	8.5616	5.098736	7.754075	7.614361	8.261654	7.740592	9.413283	7.066124	7.320296	7.866289
FC	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	4.650217	5.929155	5.650921	5.296528	5.38170525	4.069854	6.689655	7.79514	6.270033	6.136998	6.042828	7.366307	3.829609	3.206401	5.063986	4.006115	4.874099	4.26762	5.744823	4.278979	5.108466	6.980002	5.437412	4.711935	5.956626	6.413453	5.205439	5.761773	6.791201	6.655051	7.375246	7.581978	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	6.21938	6.484486	5.528374	6.059191	5.546655	6.982674	5.820913	6.335359	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	5.354215	3.133956	4.705973	4.900633	4.970266	4.92206	5.677358	4.371984	4.542395	5.017689
CE	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	2.373747	3.409697	2.522778	2.764685	2.76772675	2.098598	3.6672	4.151408	3.191899	3.370604	3.261874	3.650041	2.746843	2.757824	3.147802	3.026094	3.319963	3.499379	3.624143	2.974847	3.760281	3.458109	3.978402	3.203437	3.535234	3.676006	5.186226	1.872781	3.698456	3.876162	2.636829	2.753817	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	2.894328	3.047952	2.942893	3.04249	2.960935	3.319318	2.980597	3.057197	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	3.207386	1.96478	3.048102	2.713727	3.291389	2.818532	3.735925	2.69414	2.777901	2.8486
PE	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	13.31901	11.68516	14.93038	14.95011	13.721165	12.08262	14.71727	19.12129	16.5109	13.93843	15.71954	16.83195	11.60913	11.32087	14.60821	13.01064	12.86576	14.14383	16.71051	12.90673	15.29	14.59413	12.84609	14.6472	11.2426	11.0656	10.50611	10.24487	11.47475	11.97973	10.84418	11.20539	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	16.38343	14.74388	13.22702	14.27045	12.15538	16.18004	13.81336	15.0176	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	15.24491	9.179545	13.27939	13.4573	14.26693	13.78099	13.37346	12.49934	13.58699	14.89479
LPC	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	1.985336	3.587187	3.512746	2.229119	2.828597	2.376541	10.12079	4.001	12.57522	3.015267	2.843744	3.824854	3.313661	1.713902	4.066705	2.283039	2.141127	2.25878	2.578141	2.29802	2.226648	3.580908	2.284835	2.062072	2.212778	2.354884	2.374694	1.733888	2.424483	2.744589	2.061165	2.093544	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	3.569523	3.48271	2.912659	2.993091	2.396099	3.92955	2.688695	2.990434	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	2.445049	1.414673	2.342518	2.236741	2.387568	2.253719	2.29485	2.256921	2.30453	2.413952
PC	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	18.43064	13.72721	19.77146	20.79825	18.18189	17.06546	16.44851	30.14924	17.9391	22.95961	26.48176	27.6631	15.75915	15.77591	21.67218	18.88794	21.56993	21.89988	25.05193	19.41482	24.44903	23.90031	20.51984	21.51287	22.14274	20.13373	21.3557	17.0815	21.1864	20.57437	19.90721	22.65038	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	22.26998	22.22052	21.84318	22.17756	25.67418	27.47849	26.47858	29.02569	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	20.77021	13.56442	18.99005	19.4989	19.5686	20.6393	19.01215	17.95483	18.89013	21.34138
total FA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	154.3317	185.2361	168.1752	251.4556	189.79965	140.7847	232.6057	264.9508	215.8696	226.0595	212.4494	246.5769	135.9659	128.6336	171.9046	145.1712	145.418825	165.9092	182.8791	153.5055	170.946	246.2577	196.0287	155.2156	174.5598	155.1475	155.7252	135.0911	157.645	157.981	137.0467	148.0066	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	165.5336	160.078	155.028	153.2675	173.211	191.9855	182.6532	190.9097	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	184.4204	128.2146	178.5828	201.6631	214.7581	178.7939	198.4025	173.9663	171.7586	182.5038
SFA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	53.56734	58.89104	61.76015	82.99891	64.30436	49.88279	32.54035	74.40389	24.48528	58.62226	59.325	59.49236	42.67827	47.77448	56.5741	50.32287	49.33743	59.05086	65.13467	52.92668	61.51322	78.46966	71.576	57.31265	60.8269	53.30843	51.87406	47.32892	52.17337	53.2607	46.82604	51.61034	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	59.92835	57.45874	56.56307	58.38036	54.16209	58.30152	56.20181	62.54207	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	36.49966	28.26706	37.8818	49.56224	49.98656	37.13381	41.38633	38.70865	32.57565	35.13793
UFA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	100.7644	126.3451	106.4151	168.4567	125.495325	90.90195	200.0653	190.5469	191.3843	167.4373	153.1244	187.0845	93.28764	80.85912	115.3305	94.84834	96.0814	106.8583	117.7445	100.5789	109.4328	167.788	124.4527	97.90292	113.7329	101.8391	103.8511	87.76216	105.4716	104.7203	90.22065	96.39628	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	105.6052	102.6193	98.46492	94.88719	119.0489	133.684	126.4514	128.3677	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	119.7139	84.53165	117.9778	134.9055	142.6471	116.9949	132.7574	115.065	108.7687	116.7669
MUFA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	38.28231	49.81249	35.7885	69.64348	48.381695	32.48282	101.8587	88.80986	97.40171	83.58284	67.42692	89.24808	33.97854	24.76989	48.02497	32.88595	34.9148375	36.53009	41.66145	36.21559	35.78132	80.82412	45.60098	33.18519	49.45579	36.06272	36.66937	36.36197	37.60285	36.58757	34.58414	37.63326	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	36.33318	34.06948	34.28381	29.02538	49.8542	52.47811	49.28278	48.60563	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	64.70657	43.68294	60.60502	66.75759	72.11104	61.79901	65.64517	58.90138	62.98993	65.73688
PUFA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	62.48205	76.53256	70.62658	98.81319	77.113595	58.41912	98.20665	101.7371	93.98264	83.85441	85.6975	97.83641	59.3091	56.08923	67.30548	61.96239	61.16655	70.32821	76.08302	64.36326	73.65148	86.96388	78.85175	64.71773	64.2771	65.77638	67.18175	51.4002	67.86878	68.13276	55.63651	58.76301	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	69.27202	68.5498	64.18111	65.86181	69.19471	81.20592	77.16863	79.76203	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	83.21419	56.26459	80.09601	85.34324	92.66052	79.86106	91.37105	76.3563	76.193	81.62895
TG	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	19.19814	12.01032	10.75409	14.73858	12.17296	11.57527	9.819244	10.72271	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	8.401133	7.859552	10.48678	8.634265	14.9345	14.48264	17.30995	16.25679	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Acetate	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	18.36574	39.41539	30.16777	24.87761	41.76824	52.33333	37.97345	26.64307	47.45042	31.90559	26.17154	37.39346	38.78609	41.42647	38.97368	31.41766	44.15924	43.84396	34.03008	35.56779	28.11119	33.35196	36.14776	36.18	23.48727	25.23273	17.25818	24.88364	19.60364	12.55091	16.94182	12.67091	0.3444109	0.3467422	0.508772	0.5242321	0.2711864	0.3680982	0.3242424	0.6138614	0.6503226	0.6513158	0.87	0.9263844	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Propionate	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	2.808765	8.763956	5.61327	5.281024	10.40601	9.935898	7.51349	6.478465	8.984874	7.242236	5.266533	6.647664	10.26587	10.27466	8.36449	8.021489	9.938216	8.332759	11.2388	9.08004	9.530921	9.71709	9.972921	9.870309	4.429091	3.698182	3.354545	4.298182	5.007273	3.501818	3.267273	2.492727	0.05438067	0.006798867	0.01403509	0.02457338	0.01694915	0.02208589	0.01212121	0.03564356	0.07354838	0.06315789	0.07333333	0.1563518	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Butyrate	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	3.619124	7.98066	6.338388	6.767591	10.58112	15.61282	9.815846	6.373561	17.76303	10.61615	8.65491	11.95794	11.30478	11.05656	8.755714	8.209149	9.598089	9.965948	7.140249	7.776285	5.800658	7.70716	6.165672	6.543093	5.007273	6.987273	4.216363	5.481818	4.32	2.252727	3.016364	2.46	0.05075529	0.05779037	0.03859649	0.08600683	0.02372881	0.06625767	0.05454546	0.1861386	0.1587097	0.1855263	0.07666667	0.07035831	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Urine hippurate	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.005303	0.005071	0.00531	0.006493	0.005804	0.005314	0.005726	0.004861	0.006596	0.006958	0.005755	0.005607	0.004376	0.007388	0.00583	0.006907	0.00711	0.006283	0.005844	0.004702	0.005352	0.004868	0.003813	0.004774	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Urine indoxyl sulfate	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.002918	0.002793	0.002891	0.002784	0.002709	0.003415	0.002627	0.002583	0.003198	0.003397	0.00345	0.002858	0.003487	0.003792	0.003982	0.003537	0.003491	0.003769	0.002981	0.002865	0.002922	0.003023	0.002119	0.00262	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
NMR_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	PubChem ID
Glucose	5793
Glycogen	439177
UDP-glucose	8629
TC	23957
FC	18218231
CE	23974
PE	NA
LPC	NA
PC	NA
total FA	NA
SFA	5388925
UFA	NA
MUFA	NA
PUFA	NA
TG	2723601
Acetate	175
Propionate	104745
Butyrate	264
Urine hippurate	NA
Urine indoxyl sulfate	NA
METABOLITES_END
#END