#METABOLOMICS WORKBENCH gardinassi_20240301_092149 DATATRACK_ID:4683 STUDY_ID:ST003117 ANALYSIS_ID:AN005177 PROJECT_ID:PR001936
VERSION             	1
CREATED_ON             	April 2, 2024, 11:37 pm
#PROJECT
PR:PROJECT_TITLE                 	Metabolomics of patients with Plasmodium vivax malaria
PR:PROJECT_SUMMARY               	Background: Malaria is the leading parasitic disease worldwide, with P. vivax
PR:PROJECT_SUMMARY               	being a major challenge for its control. Several studies have indicated
PR:PROJECT_SUMMARY               	metabolomics as a promising tool for combating the disease. Objective: The study
PR:PROJECT_SUMMARY               	evaluated plasma metabolomic profiles of patients with recurrent and
PR:PROJECT_SUMMARY               	non-recurrent P. vivax malaria in the Brazilian Amazon. Methods: Metabolites
PR:PROJECT_SUMMARY               	extracted from the plasma of P. vivax-infected patients were subjected to LC-MS
PR:PROJECT_SUMMARY               	analysis. Untargeted metabolomics was applied to investigate the metabolic
PR:PROJECT_SUMMARY               	profile of the plasma in the two groups. Results: Overall, 51 recurrent and 59
PR:PROJECT_SUMMARY               	non-recurrent patients were included in the study. Longitudinal metabolomic
PR:PROJECT_SUMMARY               	analysis revealed 52 and 37 significant metabolite features from the recurrent
PR:PROJECT_SUMMARY               	and non-recurrent participants, respectively. Recurrence was associated with
PR:PROJECT_SUMMARY               	disturbances in eicosanoid metabolism. Comparison between groups suggest
PR:PROJECT_SUMMARY               	alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism,
PR:PROJECT_SUMMARY               	3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II.
PR:PROJECT_SUMMARY               	Integrative network analysis revealed enrichment of other metabolic pathways for
PR:PROJECT_SUMMARY               	the recurrent phenotype, including the butanoate metabolism, aspartate and
PR:PROJECT_SUMMARY               	asparagine metabolism, and N-glycan biosynthesis. Conclusion: The metabolites
PR:PROJECT_SUMMARY               	and metabolic pathways predicted in our study suggest potential biomarkers of
PR:PROJECT_SUMMARY               	recurrence and provide insights into targets for antimalarial development
PR:PROJECT_SUMMARY               	against P. vivax.
PR:INSTITUTE                     	University of Sao Paulo
PR:LAST_NAME                     	Gardinassi
PR:FIRST_NAME                    	Luiz Gustavo
PR:ADDRESS                       	Av. dos Bandeirantes, 3900, Campus Unviversitário, Ribeirão Preto, SP, Brazil
PR:EMAIL                         	gardinassi@eerp.usp.br
PR:PHONE                         	55 16 3315-3395
#STUDY
ST:STUDY_TITLE                   	Metabolomics of patients with Plasmodium vivax malaria
ST:STUDY_SUMMARY                 	Background: Malaria is the leading parasitic disease worldwide, with P. vivax
ST:STUDY_SUMMARY                 	being a major challenge for its control. Several studies have indicated
ST:STUDY_SUMMARY                 	metabolomics as a promising tool for combating the disease. Objective: The study
ST:STUDY_SUMMARY                 	evaluated plasma metabolomic profiles of patients with recurrent and
ST:STUDY_SUMMARY                 	non-recurrent P. vivax malaria in the Brazilian Amazon. Methods: Metabolites
ST:STUDY_SUMMARY                 	extracted from the plasma of P. vivax-infected patients were subjected to LC-MS
ST:STUDY_SUMMARY                 	analysis. Untargeted metabolomics was applied to investigate the metabolic
ST:STUDY_SUMMARY                 	profile of the plasma in the two groups. Results: Overall, 51 recurrent and 59
ST:STUDY_SUMMARY                 	non-recurrent patients were included in the study. Longitudinal metabolomic
ST:STUDY_SUMMARY                 	analysis revealed 52 and 37 significant metabolite features from the recurrent
ST:STUDY_SUMMARY                 	and non-recurrent participants, respectively. Recurrence was associated with
ST:STUDY_SUMMARY                 	disturbances in eicosanoid metabolism. Comparison between groups suggest
ST:STUDY_SUMMARY                 	alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism,
ST:STUDY_SUMMARY                 	3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II.
ST:STUDY_SUMMARY                 	Integrative network analysis revealed enrichment of other metabolic pathways for
ST:STUDY_SUMMARY                 	the recurrent phenotype, including the butanoate metabolism, aspartate and
ST:STUDY_SUMMARY                 	asparagine metabolism, and N-glycan biosynthesis. Conclusion: The metabolites
ST:STUDY_SUMMARY                 	and metabolic pathways predicted in our study suggest potential biomarkers of
ST:STUDY_SUMMARY                 	recurrence and provide insights into targets for antimalarial development
ST:STUDY_SUMMARY                 	against P. vivax.
ST:INSTITUTE                     	University of Sao Paulo
ST:LAST_NAME                     	Gardinassi
ST:FIRST_NAME                    	Luiz Gustavo
ST:ADDRESS                       	Av. dos Bandeirantes, 3900, Campus Universitário, Ribeirão Preto, SP, Brazil
ST:EMAIL                         	gardinassi@eerp.usp.br
ST:PHONE                         	55 16 3315-3395
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Male and female
#FACTORS
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	P217	ID_1	Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_1.mzML
SUBJECT_SAMPLE_FACTORS           	P143	ID_2	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_2.mzML
SUBJECT_SAMPLE_FACTORS           	P191	ID_3	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_3.mzML
SUBJECT_SAMPLE_FACTORS           	P271	ID_4	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_4.mzML
SUBJECT_SAMPLE_FACTORS           	P151	ID_5	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_5.mzML
SUBJECT_SAMPLE_FACTORS           	P134	ID_6	Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_6.mzML
SUBJECT_SAMPLE_FACTORS           	P131	ID_7	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_7.mzML
SUBJECT_SAMPLE_FACTORS           	P396	ID_8	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_8.mzML
SUBJECT_SAMPLE_FACTORS           	P035	ID_9	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_9.mzML
SUBJECT_SAMPLE_FACTORS           	P166	ID_10	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_10.mzML
SUBJECT_SAMPLE_FACTORS           	P274	ID_11	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_11.mzML
SUBJECT_SAMPLE_FACTORS           	P214	ID_12	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_12.mzML
SUBJECT_SAMPLE_FACTORS           	P429	ID_13	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_13.mzML
SUBJECT_SAMPLE_FACTORS           	P351	ID_14	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_14.mzML
SUBJECT_SAMPLE_FACTORS           	P092	ID_15	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_15.mzML
SUBJECT_SAMPLE_FACTORS           	P311	ID_16	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_16.mzML
SUBJECT_SAMPLE_FACTORS           	P111	ID_17	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_17.mzML
SUBJECT_SAMPLE_FACTORS           	P380	ID_18	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_18.mzML
SUBJECT_SAMPLE_FACTORS           	P123	ID_19	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_19.mzML
SUBJECT_SAMPLE_FACTORS           	P176	ID_20	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_20.mzML
SUBJECT_SAMPLE_FACTORS           	P276	ID_21	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_21.mzML
SUBJECT_SAMPLE_FACTORS           	P084	ID_22	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_22.mzML
SUBJECT_SAMPLE_FACTORS           	P217	ID_23	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_23.mzML
SUBJECT_SAMPLE_FACTORS           	P258	ID_24	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_24.mzML
SUBJECT_SAMPLE_FACTORS           	P197	ID_25	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_25.mzML
SUBJECT_SAMPLE_FACTORS           	P225	ID_26	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_26.mzML
SUBJECT_SAMPLE_FACTORS           	P296	ID_27	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_27.mzML
SUBJECT_SAMPLE_FACTORS           	P044	ID_28	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_28.mzML
SUBJECT_SAMPLE_FACTORS           	P005	ID_29	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_29.mzML
SUBJECT_SAMPLE_FACTORS           	P234	ID_30	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_30.mzML
SUBJECT_SAMPLE_FACTORS           	P095	ID_31	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_31.mzML
SUBJECT_SAMPLE_FACTORS           	P351	ID_32	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_32.mzML
SUBJECT_SAMPLE_FACTORS           	P030	ID_33	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_33.mzML
SUBJECT_SAMPLE_FACTORS           	P244	ID_34	Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_34.mzML
SUBJECT_SAMPLE_FACTORS           	P181	ID_35	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_35.mzML
SUBJECT_SAMPLE_FACTORS           	P186	ID_36	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_36.mzML
SUBJECT_SAMPLE_FACTORS           	P443	ID_37	Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_37.mzML
SUBJECT_SAMPLE_FACTORS           	P018	ID_38	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_38.mzML
SUBJECT_SAMPLE_FACTORS           	P322	ID_39	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_39.mzML
SUBJECT_SAMPLE_FACTORS           	P364	ID_40	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_40.mzML
SUBJECT_SAMPLE_FACTORS           	P427	ID_41	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_41.mzML
SUBJECT_SAMPLE_FACTORS           	P323	ID_42	Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_42.mzML
SUBJECT_SAMPLE_FACTORS           	P355	ID_43	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_43.mzML
SUBJECT_SAMPLE_FACTORS           	P096	ID_44	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_44.mzML
SUBJECT_SAMPLE_FACTORS           	P042	ID_45	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_45.mzML
SUBJECT_SAMPLE_FACTORS           	P155	ID_46	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_46.mzML
SUBJECT_SAMPLE_FACTORS           	P033	ID_47	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_47.mzML
SUBJECT_SAMPLE_FACTORS           	P157	ID_48	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_48.mzML
SUBJECT_SAMPLE_FACTORS           	P284	ID_49	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_49.mzML
SUBJECT_SAMPLE_FACTORS           	P147	ID_50	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_50.mzML
SUBJECT_SAMPLE_FACTORS           	P151	ID_51	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_51.mzML
SUBJECT_SAMPLE_FACTORS           	P096	ID_52	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_52.mzML
SUBJECT_SAMPLE_FACTORS           	P042	ID_53	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_53.mzML
SUBJECT_SAMPLE_FACTORS           	P317	ID_54	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_54.mzML
SUBJECT_SAMPLE_FACTORS           	P443	ID_55	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_55.mzML
SUBJECT_SAMPLE_FACTORS           	P188	ID_56	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_56.mzML
SUBJECT_SAMPLE_FACTORS           	P207	ID_57	Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_57.mzML
SUBJECT_SAMPLE_FACTORS           	P240	ID_58	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_58.mzML
SUBJECT_SAMPLE_FACTORS           	P145	ID_59	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_59.mzML
SUBJECT_SAMPLE_FACTORS           	P285	ID_60	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_60.mzML
SUBJECT_SAMPLE_FACTORS           	P143	ID_61	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_61.mzML
SUBJECT_SAMPLE_FACTORS           	P113	ID_62	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_62.mzML
SUBJECT_SAMPLE_FACTORS           	P019	ID_63	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_63.mzML
SUBJECT_SAMPLE_FACTORS           	P016	ID_64	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_64.mzML
SUBJECT_SAMPLE_FACTORS           	P053	ID_65	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_65.mzML
SUBJECT_SAMPLE_FACTORS           	P360	ID_66	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_66.mzML
SUBJECT_SAMPLE_FACTORS           	P005	ID_67	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_67.mzML
SUBJECT_SAMPLE_FACTORS           	P169	ID_68	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_68.mzML
SUBJECT_SAMPLE_FACTORS           	P084	ID_69	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_69.mzML
SUBJECT_SAMPLE_FACTORS           	P015	ID_70	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_70.mzML
SUBJECT_SAMPLE_FACTORS           	P061	ID_71	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_71.mzML
SUBJECT_SAMPLE_FACTORS           	P265	ID_72	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_72.mzML
SUBJECT_SAMPLE_FACTORS           	P357	ID_73	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_73.mzML
SUBJECT_SAMPLE_FACTORS           	P258	ID_74	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_74.mzML
SUBJECT_SAMPLE_FACTORS           	P171	ID_75	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_75.mzML
SUBJECT_SAMPLE_FACTORS           	P083	ID_76	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_76.mzML
SUBJECT_SAMPLE_FACTORS           	P243	ID_77	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_77.mzML
SUBJECT_SAMPLE_FACTORS           	P021	ID_78	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_78.mzML
SUBJECT_SAMPLE_FACTORS           	P166	ID_79	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_79.mzML
SUBJECT_SAMPLE_FACTORS           	P274	ID_80	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_80.mzML
SUBJECT_SAMPLE_FACTORS           	P360	ID_81	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_81.mzML
SUBJECT_SAMPLE_FACTORS           	P053	ID_82	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_82.mzML
SUBJECT_SAMPLE_FACTORS           	P317	ID_83	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_83.mzML
SUBJECT_SAMPLE_FACTORS           	P184	ID_84	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_84.mzML
SUBJECT_SAMPLE_FACTORS           	P296	ID_86	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_86.mzML
SUBJECT_SAMPLE_FACTORS           	P163	ID_87	Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_87.mzML
SUBJECT_SAMPLE_FACTORS           	P277	ID_88	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_88.mzML
SUBJECT_SAMPLE_FACTORS           	P197	ID_89	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_89.mzML
SUBJECT_SAMPLE_FACTORS           	P322	ID_90	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_90.mzML
SUBJECT_SAMPLE_FACTORS           	P343	ID_91	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_91.mzML
SUBJECT_SAMPLE_FACTORS           	P131	ID_92	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_92.mzML
SUBJECT_SAMPLE_FACTORS           	P021	ID_93	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_93.mzML
SUBJECT_SAMPLE_FACTORS           	P323	ID_94	Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_94.mzML
SUBJECT_SAMPLE_FACTORS           	P277	ID_95	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_95.mzML
SUBJECT_SAMPLE_FACTORS           	P337	ID_96	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_96.mzML
SUBJECT_SAMPLE_FACTORS           	P111	ID_97	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_97.mzML
SUBJECT_SAMPLE_FACTORS           	P357	ID_98	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_98.mzML
SUBJECT_SAMPLE_FACTORS           	P018	ID_99	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_99.mzML
SUBJECT_SAMPLE_FACTORS           	P353	ID_100	Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_100.mzML
SUBJECT_SAMPLE_FACTORS           	P384	ID_101	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_101.mzML
SUBJECT_SAMPLE_FACTORS           	P188	ID_102	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_102.mzML
SUBJECT_SAMPLE_FACTORS           	P063	ID_103	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_103.mzML
SUBJECT_SAMPLE_FACTORS           	P360	ID_104	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_104.mzML
SUBJECT_SAMPLE_FACTORS           	P256	ID_105	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_105.mzML
SUBJECT_SAMPLE_FACTORS           	P024	ID_106	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_106.mzML
SUBJECT_SAMPLE_FACTORS           	P296	ID_108	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_108.mzML
SUBJECT_SAMPLE_FACTORS           	P145	ID_109	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_109.mzML
SUBJECT_SAMPLE_FACTORS           	P010	ID_110	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_110.mzML
SUBJECT_SAMPLE_FACTORS           	P015	ID_111	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_111.mzML
SUBJECT_SAMPLE_FACTORS           	P243	ID_112	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_112.mzML
SUBJECT_SAMPLE_FACTORS           	P343	ID_113	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_113.mzML
SUBJECT_SAMPLE_FACTORS           	P061	ID_114	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_114.mzML
SUBJECT_SAMPLE_FACTORS           	P042	ID_115	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_115.mzML
SUBJECT_SAMPLE_FACTORS           	P257	ID_116	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_116.mzML
SUBJECT_SAMPLE_FACTORS           	P343	ID_117	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_117.mzML
SUBJECT_SAMPLE_FACTORS           	P203	ID_118	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_118.mzML
SUBJECT_SAMPLE_FACTORS           	P176	ID_119	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_119.mzML
SUBJECT_SAMPLE_FACTORS           	P220	ID_120	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_120.mzML
SUBJECT_SAMPLE_FACTORS           	P134	ID_121	Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_121.mzML
SUBJECT_SAMPLE_FACTORS           	P018	ID_122	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_122.mzML
SUBJECT_SAMPLE_FACTORS           	P257	ID_123	Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_123.mzML
SUBJECT_SAMPLE_FACTORS           	P217	ID_124	Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_124.mzML
SUBJECT_SAMPLE_FACTORS           	P214	ID_125	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_125.mzML
SUBJECT_SAMPLE_FACTORS           	P184	ID_126	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_126.mzML
SUBJECT_SAMPLE_FACTORS           	P188	ID_127	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_127.mzML
SUBJECT_SAMPLE_FACTORS           	P031	ID_128	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_128.mzML
SUBJECT_SAMPLE_FACTORS           	P396	ID_129	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_129.mzML
SUBJECT_SAMPLE_FACTORS           	P030	ID_130	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_130.mzML
SUBJECT_SAMPLE_FACTORS           	P096	ID_131	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_131.mzML
SUBJECT_SAMPLE_FACTORS           	P205	ID_132	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_132.mzML
SUBJECT_SAMPLE_FACTORS           	P281	ID_133	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_133.mzML
SUBJECT_SAMPLE_FACTORS           	P220	ID_134	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_134.mzML
SUBJECT_SAMPLE_FACTORS           	P355	ID_135	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_135.mzML
SUBJECT_SAMPLE_FACTORS           	P258	ID_136	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_136.mzML
SUBJECT_SAMPLE_FACTORS           	P120	ID_137	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_137.mzML
SUBJECT_SAMPLE_FACTORS           	P172	ID_138	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_138.mzML
SUBJECT_SAMPLE_FACTORS           	P079	ID_139	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_139.mzML
SUBJECT_SAMPLE_FACTORS           	P124	ID_140	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_140.mzML
SUBJECT_SAMPLE_FACTORS           	P259	ID_141	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_141.mzML
SUBJECT_SAMPLE_FACTORS           	P328	ID_142	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_142.mzML
SUBJECT_SAMPLE_FACTORS           	P311	ID_143	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_143.mzML
SUBJECT_SAMPLE_FACTORS           	P211	ID_144	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_144.mzML
SUBJECT_SAMPLE_FACTORS           	P020	ID_145	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_145.mzML
SUBJECT_SAMPLE_FACTORS           	P429	ID_146	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_146.mzML
SUBJECT_SAMPLE_FACTORS           	P192	ID_147	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_147.mzML
SUBJECT_SAMPLE_FACTORS           	P207	ID_148	Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_148.mzML
SUBJECT_SAMPLE_FACTORS           	P120	ID_149	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_149.mzML
SUBJECT_SAMPLE_FACTORS           	P084	ID_150	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_150.mzML
SUBJECT_SAMPLE_FACTORS           	P239	ID_151	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_151.mzML
SUBJECT_SAMPLE_FACTORS           	P134	ID_152	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_152.mzML
SUBJECT_SAMPLE_FACTORS           	P009	ID_153	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_153.mzML
SUBJECT_SAMPLE_FACTORS           	P203	ID_154	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_154.mzML
SUBJECT_SAMPLE_FACTORS           	P024	ID_155	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_155.mzML
SUBJECT_SAMPLE_FACTORS           	P251	ID_156	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_156.mzML
SUBJECT_SAMPLE_FACTORS           	P155	ID_157	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_157.mzML
SUBJECT_SAMPLE_FACTORS           	P311	ID_158	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_158.mzML
SUBJECT_SAMPLE_FACTORS           	P277	ID_159	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_159.mzML
SUBJECT_SAMPLE_FACTORS           	P285	ID_160	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_160.mzML
SUBJECT_SAMPLE_FACTORS           	P176	ID_161	Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_161.mzML
SUBJECT_SAMPLE_FACTORS           	P244	ID_162	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_162.mzML
SUBJECT_SAMPLE_FACTORS           	P353	ID_163	Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_163.mzML
SUBJECT_SAMPLE_FACTORS           	P177	ID_164	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_164.mzML
SUBJECT_SAMPLE_FACTORS           	P020	ID_165	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_165.mzML
SUBJECT_SAMPLE_FACTORS           	P116	ID_166	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_166.mzML
SUBJECT_SAMPLE_FACTORS           	P031	ID_167	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_167.mzML
SUBJECT_SAMPLE_FACTORS           	P284	ID_168	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_168.mzML
SUBJECT_SAMPLE_FACTORS           	P145	ID_169	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_169.mzML
SUBJECT_SAMPLE_FACTORS           	P140	ID_170	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_170.mzML
SUBJECT_SAMPLE_FACTORS           	P199	ID_171	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_171.mzML
SUBJECT_SAMPLE_FACTORS           	P092	ID_172	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_172.mzML
SUBJECT_SAMPLE_FACTORS           	P035	ID_173	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_173.mzML
SUBJECT_SAMPLE_FACTORS           	P157	ID_174	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_174.mzML
SUBJECT_SAMPLE_FACTORS           	P147	ID_175	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_175.mzML
SUBJECT_SAMPLE_FACTORS           	P281	ID_176	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_176.mzML
SUBJECT_SAMPLE_FACTORS           	P443	ID_177	Class:recurrence | Day:R | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_177.mzML
SUBJECT_SAMPLE_FACTORS           	P113	ID_178	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_178.mzML
SUBJECT_SAMPLE_FACTORS           	P337	ID_179	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_179.mzML
SUBJECT_SAMPLE_FACTORS           	P177	ID_180	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_180.mzML
SUBJECT_SAMPLE_FACTORS           	P351	ID_181	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_181.mzML
SUBJECT_SAMPLE_FACTORS           	P353	ID_182	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_182.mzML
SUBJECT_SAMPLE_FACTORS           	P212	ID_183	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_183.mzML
SUBJECT_SAMPLE_FACTORS           	P123	ID_184	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_184.mzML
SUBJECT_SAMPLE_FACTORS           	P016	ID_185	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_185.mzML
SUBJECT_SAMPLE_FACTORS           	P020	ID_186	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_186.mzML
SUBJECT_SAMPLE_FACTORS           	P199	ID_187	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_187.mzML
SUBJECT_SAMPLE_FACTORS           	P063	ID_188	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_188.mzML
SUBJECT_SAMPLE_FACTORS           	P388	ID_189	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_189.mzML
SUBJECT_SAMPLE_FACTORS           	P256	ID_190	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_190.mzML
SUBJECT_SAMPLE_FACTORS           	P009	ID_191	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_191.mzML
SUBJECT_SAMPLE_FACTORS           	P113	ID_192	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_192.mzML
SUBJECT_SAMPLE_FACTORS           	P010	ID_193	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_193.mzML
SUBJECT_SAMPLE_FACTORS           	P396	ID_194	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_194.mzML
SUBJECT_SAMPLE_FACTORS           	P299	ID_195	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_195.mzML
SUBJECT_SAMPLE_FACTORS           	P234	ID_196	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_196.mzML
SUBJECT_SAMPLE_FACTORS           	P083	ID_197	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_197.mzML
SUBJECT_SAMPLE_FACTORS           	P281	ID_198	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_198.mzML
SUBJECT_SAMPLE_FACTORS           	P143	ID_199	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_199.mzML
SUBJECT_SAMPLE_FACTORS           	P115	ID_200	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_200.mzML
SUBJECT_SAMPLE_FACTORS           	P338	ID_201	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_201.mzML
SUBJECT_SAMPLE_FACTORS           	P203	ID_202	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_202.mzML
SUBJECT_SAMPLE_FACTORS           	P384	ID_203	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_203.mzML
SUBJECT_SAMPLE_FACTORS           	P033	ID_204	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_204.mzML
SUBJECT_SAMPLE_FACTORS           	P207	ID_205	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_205.mzML
SUBJECT_SAMPLE_FACTORS           	P240	ID_206	Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_206.mzML
SUBJECT_SAMPLE_FACTORS           	P083	ID_207	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_207.mzML
SUBJECT_SAMPLE_FACTORS           	P079	ID_208	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_208.mzML
SUBJECT_SAMPLE_FACTORS           	P038	ID_209	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_209.mzML
SUBJECT_SAMPLE_FACTORS           	P036	ID_210	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_210.mzML
SUBJECT_SAMPLE_FACTORS           	P323	ID_211	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_211.mzML
SUBJECT_SAMPLE_FACTORS           	P214	ID_212	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_212.mzML
SUBJECT_SAMPLE_FACTORS           	P380	ID_213	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_213.mzML
SUBJECT_SAMPLE_FACTORS           	P033	ID_214	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_214.mzML
SUBJECT_SAMPLE_FACTORS           	P323	ID_215	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_215.mzML
SUBJECT_SAMPLE_FACTORS           	P328	ID_216	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_216.mzML
SUBJECT_SAMPLE_FACTORS           	P427	ID_217	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_217.mzML
SUBJECT_SAMPLE_FACTORS           	P240	ID_218	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_218.mzML
SUBJECT_SAMPLE_FACTORS           	P234	ID_219	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_219.mzML
SUBJECT_SAMPLE_FACTORS           	P364	ID_220	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_220.mzML
SUBJECT_SAMPLE_FACTORS           	P157	ID_221	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_221.mzML
SUBJECT_SAMPLE_FACTORS           	P036	ID_222	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_222.mzML
SUBJECT_SAMPLE_FACTORS           	P009	ID_223	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_223.mzML
SUBJECT_SAMPLE_FACTORS           	P355	ID_224	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_224.mzML
SUBJECT_SAMPLE_FACTORS           	P243	ID_225	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_225.mzML
SUBJECT_SAMPLE_FACTORS           	P120	ID_226	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_226.mzML
SUBJECT_SAMPLE_FACTORS           	P251	ID_227	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_227.mzML
SUBJECT_SAMPLE_FACTORS           	P166	ID_228	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_228.mzML
SUBJECT_SAMPLE_FACTORS           	P192	ID_229	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_229.mzML
SUBJECT_SAMPLE_FACTORS           	P317	ID_230	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_230.mzML
SUBJECT_SAMPLE_FACTORS           	P284	ID_231	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_231.mzML
SUBJECT_SAMPLE_FACTORS           	P030	ID_232	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_232.mzML
SUBJECT_SAMPLE_FACTORS           	P380	ID_233	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_233.mzML
SUBJECT_SAMPLE_FACTORS           	P225	ID_234	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_234.mzML
SUBJECT_SAMPLE_FACTORS           	P015	ID_235	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_235.mzML
SUBJECT_SAMPLE_FACTORS           	P225	ID_236	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_236.mzML
SUBJECT_SAMPLE_FACTORS           	P271	ID_237	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_237.mzML
SUBJECT_SAMPLE_FACTORS           	P095	ID_238	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_238.mzML
SUBJECT_SAMPLE_FACTORS           	P199	ID_239	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_239.mzML
SUBJECT_SAMPLE_FACTORS           	P251	ID_240	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_240.mzML
SUBJECT_SAMPLE_FACTORS           	P155	ID_241	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_241.mzML
SUBJECT_SAMPLE_FACTORS           	P010	ID_242	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_242.mzML
SUBJECT_SAMPLE_FACTORS           	P274	ID_243	Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_243.mzML
SUBJECT_SAMPLE_FACTORS           	P005	ID_244	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_244.mzML
SUBJECT_SAMPLE_FACTORS           	P181	ID_245	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_245.mzML
SUBJECT_SAMPLE_FACTORS           	P205	ID_246	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_246.mzML
SUBJECT_SAMPLE_FACTORS           	P211	ID_247	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_247.mzML
SUBJECT_SAMPLE_FACTORS           	P299	ID_248	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_248.mzML
SUBJECT_SAMPLE_FACTORS           	P115	ID_249	Class:recurrence | Day:R | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_249.mzML
SUBJECT_SAMPLE_FACTORS           	P256	ID_250	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_250.mzML
SUBJECT_SAMPLE_FACTORS           	P429	ID_251	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_251.mzML
SUBJECT_SAMPLE_FACTORS           	P191	ID_252	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_252.mzML
SUBJECT_SAMPLE_FACTORS           	P259	ID_253	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_253.mzML
SUBJECT_SAMPLE_FACTORS           	P328	ID_254	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_254.mzML
SUBJECT_SAMPLE_FACTORS           	P019	ID_255	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_255.mzML
SUBJECT_SAMPLE_FACTORS           	P240	ID_256	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_256.mzML
SUBJECT_SAMPLE_FACTORS           	P169	ID_257	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_257.mzML
SUBJECT_SAMPLE_FACTORS           	P172	ID_258	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_258.mzML
SUBJECT_SAMPLE_FACTORS           	P140	ID_259	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_259.mzML
SUBJECT_SAMPLE_FACTORS           	P124	ID_260	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_260.mzML
SUBJECT_SAMPLE_FACTORS           	P239	ID_261	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_261.mzML
SUBJECT_SAMPLE_FACTORS           	P140	ID_262	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_262.mzML
SUBJECT_SAMPLE_FACTORS           	P239	ID_263	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_263.mzML
SUBJECT_SAMPLE_FACTORS           	P338	ID_264	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_264.mzML
SUBJECT_SAMPLE_FACTORS           	P240	ID_265	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_265.mzML
SUBJECT_SAMPLE_FACTORS           	P370	ID_266	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_266.mzML
SUBJECT_SAMPLE_FACTORS           	P079	ID_267	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_267.mzML
SUBJECT_SAMPLE_FACTORS           	P124	ID_268	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_268.mzML
SUBJECT_SAMPLE_FACTORS           	P265	ID_269	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_269.mzML
SUBJECT_SAMPLE_FACTORS           	P092	ID_270	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_270.mzML
SUBJECT_SAMPLE_FACTORS           	P244	ID_271	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_271.mzML
SUBJECT_SAMPLE_FACTORS           	P116	ID_272	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_272.mzML
SUBJECT_SAMPLE_FACTORS           	P063	ID_273	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_273.mzML
SUBJECT_SAMPLE_FACTORS           	P271	ID_274	Class:recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_274.mzML
SUBJECT_SAMPLE_FACTORS           	P205	ID_275	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_275.mzML
SUBJECT_SAMPLE_FACTORS           	P285	ID_276	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_276.mzML
SUBJECT_SAMPLE_FACTORS           	P035	ID_277	Class:non-recurrence | Day:90 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_277.mzML
SUBJECT_SAMPLE_FACTORS           	P095	ID_278	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_278.mzML
SUBJECT_SAMPLE_FACTORS           	P276	ID_279	Class:recurrence | Day:R | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_279.mzML
SUBJECT_SAMPLE_FACTORS           	P031	ID_280	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_280.mzML
SUBJECT_SAMPLE_FACTORS           	P212	ID_281	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_281.mzML
SUBJECT_SAMPLE_FACTORS           	P021	ID_282	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_282.mzML
SUBJECT_SAMPLE_FACTORS           	P370	ID_283	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_283.mzML
SUBJECT_SAMPLE_FACTORS           	P257	ID_284	Class:non-recurrence | Day:90 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_284.mzML
SUBJECT_SAMPLE_FACTORS           	P276	ID_285	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_285.mzML
SUBJECT_SAMPLE_FACTORS           	P337	ID_286	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_286.mzML
SUBJECT_SAMPLE_FACTORS           	P147	ID_287	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_287.mzML
SUBJECT_SAMPLE_FACTORS           	P115	ID_288	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_288.mzML
SUBJECT_SAMPLE_FACTORS           	P061	ID_289	Class:non-recurrence | Day:0 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_289.mzML
SUBJECT_SAMPLE_FACTORS           	P265	ID_290	Class:recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_290.mzML
SUBJECT_SAMPLE_FACTORS           	P111	ID_291	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_291.mzML
SUBJECT_SAMPLE_FACTORS           	P163	ID_292	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_292.mzML
SUBJECT_SAMPLE_FACTORS           	P171	ID_293	Class:non-recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_293.mzML
SUBJECT_SAMPLE_FACTORS           	P181	ID_294	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_294.mzML
SUBJECT_SAMPLE_FACTORS           	P131	ID_295	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_295.mzML
SUBJECT_SAMPLE_FACTORS           	P019	ID_296	Class:recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_296.mzML
SUBJECT_SAMPLE_FACTORS           	P172	ID_297	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_297.mzML
SUBJECT_SAMPLE_FACTORS           	P186	ID_298	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_298.mzML
SUBJECT_SAMPLE_FACTORS           	P145	ID_299	Class:recurrence | Day:6 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_299.mzML
SUBJECT_SAMPLE_FACTORS           	P038	ID_300	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_300.mzML
SUBJECT_SAMPLE_FACTORS           	P145	ID_301	Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_301.mzML
SUBJECT_SAMPLE_FACTORS           	P163	ID_302	Class:recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_302.mzML
SUBJECT_SAMPLE_FACTORS           	P197	ID_303	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_303.mzML
SUBJECT_SAMPLE_FACTORS           	P116	ID_304	Class:recurrence | Day:R | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_304.mzML
SUBJECT_SAMPLE_FACTORS           	P044	ID_305	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_305.mzML
SUBJECT_SAMPLE_FACTORS           	P364	ID_306	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_306.mzML
SUBJECT_SAMPLE_FACTORS           	P177	ID_307	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_307.mzML
SUBJECT_SAMPLE_FACTORS           	P123	ID_308	Class:recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_308.mzML
SUBJECT_SAMPLE_FACTORS           	P212	ID_309	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_309.mzML
SUBJECT_SAMPLE_FACTORS           	P171	ID_310	Class:non-recurrence | Day:0 | Treatment:DHA+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_310.mzML
SUBJECT_SAMPLE_FACTORS           	P016	ID_311	Class:non-recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_311.mzML
SUBJECT_SAMPLE_FACTORS           	P184	ID_312	Class:recurrence | Day:6 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_312.mzML
SUBJECT_SAMPLE_FACTORS           	P192	ID_313	Class:non-recurrence | Day:0 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_313.mzML
SUBJECT_SAMPLE_FACTORS           	P220	ID_314	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_314.mzML
SUBJECT_SAMPLE_FACTORS           	P357	ID_315	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_315.mzML
SUBJECT_SAMPLE_FACTORS           	P191	ID_316	Class:non-recurrence | Day:90 | Treatment:DHA+PQ42 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_316.mzML
SUBJECT_SAMPLE_FACTORS           	P038	ID_317	Class:non-recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_317.mzML
SUBJECT_SAMPLE_FACTORS           	P044	ID_318	Class:non-recurrence | Day:0 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_318.mzML
SUBJECT_SAMPLE_FACTORS           	P370	ID_319	Class:non-recurrence | Day:90 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_319.mzML
SUBJECT_SAMPLE_FACTORS           	P384	ID_320	Class:recurrence | Day:6 | Treatment:CQ+PQDHA+PQ422 | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_320.mzML
SUBJECT_SAMPLE_FACTORS           	P024	ID_321	Class:non-recurrence | Day:6 | Treatment:CQ+PQ | Sample source:Plasma	RAW_FILE_NAME(RawFileName)=ID_321.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	Individuals with P. vivax were admitted at the Fundação de Medicina Tropical
CO:COLLECTION_SUMMARY            	Dr. Heitor Vieira Dourado (FMT-HVD), a reference center for infectious diseases
CO:COLLECTION_SUMMARY            	located in Manaus, Western Brazilian Amazon. At inclusion into the CURAVIVAX
CO:COLLECTION_SUMMARY            	study, patient socio-demographic data including sex, age, weight, body-mass
CO:COLLECTION_SUMMARY            	index and ethnicity was captured. Laboratory analyses were done at pre-treatment
CO:COLLECTION_SUMMARY            	through the treatment days and follow-up including the day of recurrence.
CO:COLLECTION_SUMMARY            	Patients of both sexes, aged > 6 months, body weight ≥ 5 kg, with symptomatic
CO:COLLECTION_SUMMARY            	P. vivax monoinfection, parasite density between 100 and 100,000 parasites/ µL
CO:COLLECTION_SUMMARY            	were included. Exclusion criteria included the use of antimalarials in the last
CO:COLLECTION_SUMMARY            	60 days, mixed Plasmodium infections especially P. falciparum, pregnancy, or
CO:COLLECTION_SUMMARY            	lactation and concomitant or underlying diseases. Patients with dengue and other
CO:COLLECTION_SUMMARY            	febrile diseases were excluded during screening. After confirmation of malaria
CO:COLLECTION_SUMMARY            	vivax by thick blood smears, whole blood and plasma samples were collected,
CO:COLLECTION_SUMMARY            	aliquoted and stored at -80OC until needed for analysis. Plasma samples for day
CO:COLLECTION_SUMMARY            	of inclusion and before treatment (D0), day six (D6), day ninety (D90) and
CO:COLLECTION_SUMMARY            	recurrence day (DR) were used for this study.
CO:SAMPLE_TYPE                   	Blood (plasma)
CO:STORAGE_CONDITIONS            	-80℃
#TREATMENT
TR:TREATMENT_SUMMARY             	Patients were randomly assigned to one of four treatment groups: Group1-
TR:TREATMENT_SUMMARY             	chloroquine (CQ) for 3 days + primaquine (PQ) for 14 days (0.50mg/kg/day)
TR:TREATMENT_SUMMARY             	concurrently. Group 2 - dihydroartemisinin/piperaquine (DHA/PPQ) for 3 days + PQ
TR:TREATMENT_SUMMARY             	for 14 days (0.50mg/kg/day) concurrently, Group 3 - CQ for 3 days + PQ for 14
TR:TREATMENT_SUMMARY             	days (0.50mg/kg/day) starting on day 42 after the initial CQ, and Group 4 -
TR:TREATMENT_SUMMARY             	DHA/PPQ for 3 days + PQ for 14 days (0.50mg/kg/day) starting on day 42 after the
TR:TREATMENT_SUMMARY             	initial DHA/PPQ.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Metabolites were extracted from 150 µL of sample (plasma EDTA), which was mixed
SP:SAMPLEPREP_SUMMARY            	with acetonitrile (2:1, v/v; -5 °C) and centrifuged at 15,000 rpm for 15 min to
SP:SAMPLEPREP_SUMMARY            	remove proteins. Stable isotopes caffeine-¹³C3, tyrosine-15N and
SP:SAMPLEPREP_SUMMARY            	progesterone-d9 were used as internal standards.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	The binary mobile phases were water 0.5% formic acid with 5 mM of ammonium
CH:CHROMATOGRAPHY_SUMMARY        	formate (A), and acetonitrile (B). Their gradient elution started with 20% (B)
CH:CHROMATOGRAPHY_SUMMARY        	for 5 min, then linearly increased to 100% (B) in 30 min and kept constant for 8
CH:CHROMATOGRAPHY_SUMMARY        	min in 100% (B). The eluent was restored to the initial conditions in 4 minutes
CH:CHROMATOGRAPHY_SUMMARY        	to re-equilibrate the column and held for the remaining 8 minutes. The flow rate
CH:CHROMATOGRAPHY_SUMMARY        	was kept at 0.5 mL min-1. The injection volume for analysis was 3 μL, and the
CH:CHROMATOGRAPHY_SUMMARY        	column temperature was set at 35 °C.
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Agilent 1220 Infinity
CH:COLUMN_NAME                   	Agilent ZORBAX Eclipse Plus C18 (100 x 4.6mm,3.5um)
CH:SOLVENT_A                     	100% water; 0.5% formic acid; 5 mM of ammonium formate
CH:SOLVENT_B                     	100% acetonitrile
CH:FLOW_GRADIENT                 	gradient elution started with 20% (B) for 5 min, then linearly increased to 100%
CH:FLOW_GRADIENT                 	(B) in 30 min and kept constant for 8 min in 100% (B). The eluent was restored
CH:FLOW_GRADIENT                 	to the initial conditions in 4 minutes to re-equilibrate the column and held for
CH:FLOW_GRADIENT                 	the remaining 8 minutes.
CH:FLOW_RATE                     	0.5 mL/min
CH:COLUMN_TEMPERATURE            	35
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	The electrospray ionization was operating with the following settings: spray
MS:MS_COMMENTS                   	voltage 3.5 kV; capillary temperature: 269 °C; S-lens RF level 50 V; sheath gas
MS:MS_COMMENTS                   	flow rate at 53 L min-1; aux gas flow rate at 14 L min-1; sweep gas flow rate 3
MS:MS_COMMENTS                   	L min-1. The high-resolution mass-spectrometry was obtained under full MS/dd-MS2
MS:MS_COMMENTS                   	mode. The mass range in the full MS scanning experiments was m/z 80-1200. The
MS:MS_COMMENTS                   	max IT was set at 200 ms, and AGC target was set at 1 x 106. Resolving power was
MS:MS_COMMENTS                   	set at 140,000.
MS:MS_RESULTS_FILE               	ST003117_AN005177_Results.txt	UNITS:normalized intensity	Has m/z:Yes	Has RT:Yes	RT units:Seconds
#END