#METABOLOMICS WORKBENCH cmann_20250321_052300 DATATRACK_ID:5765 STUDY_ID:ST003814 ANALYSIS_ID:AN006272 PROJECT_ID:PR002385
VERSION             	1
CREATED_ON             	March 24, 2025, 10:02 pm
#PROJECT
PR:PROJECT_TITLE                 	Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat
PR:PROJECT_TITLE                 	Oxidation in Muscle
PR:PROJECT_SUMMARY               	Dietary restriction of the sulfur-containing amino acids methionine and cysteine
PR:PROJECT_SUMMARY               	(SAAR) improves body composition, enhances insulin sensitivity, and extends
PR:PROJECT_SUMMARY               	lifespan; benefits seen also with endurance exercise. Yet, the impact of SAAR on
PR:PROJECT_SUMMARY               	skeletal muscle remains largely unexplored. Here we demonstrate that one week of
PR:PROJECT_SUMMARY               	SAAR in sedentary, young, male mice increases endurance exercise capacity.
PR:PROJECT_SUMMARY               	Indirect calorimetry showed that SAAR increased lipid oxidation at rest and
PR:PROJECT_SUMMARY               	delayed the onset of carbohydrate utilization during exercise. Transcriptomic
PR:PROJECT_SUMMARY               	analysis revealed increased expression of genes involved in fatty acid
PR:PROJECT_SUMMARY               	catabolism especially in glycolytic muscle following SAAR. These findings were
PR:PROJECT_SUMMARY               	functionally supported by increased fatty acid circulatory turnover flux and
PR:PROJECT_SUMMARY               	muscle β-oxidation. Reducing lipid uptake from circulation through endothelial
PR:PROJECT_SUMMARY               	cell (EC)-specific CD36 deletion attenuated the running phenotype.
PR:PROJECT_SUMMARY               	Mechanistically, VEGF-signaling inhibition prevented exercise increases
PR:PROJECT_SUMMARY               	following SAAR, without affecting angiogenesis, implicating noncanonical VEGF
PR:PROJECT_SUMMARY               	signaling and EC CD36-dependent fatty acid transport in regulating exercise
PR:PROJECT_SUMMARY               	capacity by influencing muscle substrate availability.
PR:INSTITUTE                     	Princeton University
PR:DEPARTMENT                    	Department of Chemistry
PR:LABORATORY                    	Prof. Dr. Joshua Rabinowitz
PR:LAST_NAME                     	Mann
PR:FIRST_NAME                    	Charlotte G.
PR:ADDRESS                       	Joseph Stelzmann Strasse 26
PR:EMAIL                         	cmann5@uni-koeln.de
PR:PHONE                         	+49 221 478-84102
#STUDY
ST:STUDY_TITLE                   	Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat
ST:STUDY_TITLE                   	Oxidation in Muscle - extensor digitorum longus (EDL) versus soleus (Sol) on Con
ST:STUDY_TITLE                   	and SAAR diet lipidomics
ST:STUDY_SUMMARY                 	Dietary restriction of the sulfur-containing amino acids methionine and cysteine
ST:STUDY_SUMMARY                 	(SAAR) improves body composition, enhances insulin sensitivity, and extends
ST:STUDY_SUMMARY                 	lifespan; benefits seen also with endurance exercise. Yet, the impact of SAAR on
ST:STUDY_SUMMARY                 	skeletal muscle remains largely unexplored. Here we demonstrate that one week of
ST:STUDY_SUMMARY                 	SAAR in sedentary, young, male mice increases endurance exercise capacity.
ST:STUDY_SUMMARY                 	Indirect calorimetry showed that SAAR increased lipid oxidation at rest and
ST:STUDY_SUMMARY                 	delayed the onset of carbohydrate utilization during exercise. Transcriptomic
ST:STUDY_SUMMARY                 	analysis revealed increased expression of genes involved in fatty acid
ST:STUDY_SUMMARY                 	catabolism especially in glycolytic muscle following SAAR. These findings were
ST:STUDY_SUMMARY                 	functionally supported by increased fatty acid circulatory turnover flux and
ST:STUDY_SUMMARY                 	muscle β-oxidation. Reducing lipid uptake from circulation through endothelial
ST:STUDY_SUMMARY                 	cell (EC)-specific CD36 deletion attenuated the running phenotype.
ST:STUDY_SUMMARY                 	Mechanistically, VEGF-signaling inhibition prevented exercise increases
ST:STUDY_SUMMARY                 	following SAAR, without affecting angiogenesis, implicating noncanonical VEGF
ST:STUDY_SUMMARY                 	signaling and EC CD36-dependent fatty acid transport in regulating exercise
ST:STUDY_SUMMARY                 	capacity by influencing muscle substrate availability. Here we performed
ST:STUDY_SUMMARY                 	lipidomics using EDL and Sol to evaluate the systemic effects of the diet on
ST:STUDY_SUMMARY                 	muscle lipid composition. One week of dietary treatment was not sufficient to
ST:STUDY_SUMMARY                 	significantly alter a wide range of lipid species in the muscle, prompting us to
ST:STUDY_SUMMARY                 	investigate changes in functional utilization rather than lipid storage.
ST:INSTITUTE                     	Princeton University
ST:LAST_NAME                     	Mann
ST:FIRST_NAME                    	Charlotte Greta
ST:ADDRESS                       	Joseph Stelzmann Strasse 26
ST:EMAIL                         	cmann5@uni-koeln.de
ST:PHONE                         	+49 221 478-84102
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
SU:GENOTYPE_STRAIN               	c57bl/6j
SU:AGE_OR_AGE_RANGE              	14 weeks
SU:GENDER                        	Male
SU:ANIMAL_FEED                   	Con versus SAAR diet
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	1	1	Sample source:Mouse Soleus muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=1.mzXML
SUBJECT_SAMPLE_FACTORS           	2	2	Sample source:Mouse Soleus muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=2.mzXML
SUBJECT_SAMPLE_FACTORS           	3	3	Sample source:Mouse Soleus muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=3.mzXML
SUBJECT_SAMPLE_FACTORS           	4	4	Sample source:Mouse Soleus muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=4.mzXML
SUBJECT_SAMPLE_FACTORS           	6	5	Sample source:Mouse Soleus muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=5.mzXML
SUBJECT_SAMPLE_FACTORS           	8	6	Sample source:Mouse Soleus muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=6.mzXML
SUBJECT_SAMPLE_FACTORS           	10	7	Sample source:Mouse Soleus muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=7.mzXML
SUBJECT_SAMPLE_FACTORS           	12	8	Sample source:Mouse Soleus muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=8.mzXML
SUBJECT_SAMPLE_FACTORS           	14	9	Sample source:Mouse Soleus muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=9.mzXML
SUBJECT_SAMPLE_FACTORS           	16	10	Sample source:Mouse Soleus muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=10.mzXML
SUBJECT_SAMPLE_FACTORS           	18	11	Sample source:Mouse Soleus muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=11.mzXML
SUBJECT_SAMPLE_FACTORS           	20	12	Sample source:Mouse Soleus muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=12.mzXML
SUBJECT_SAMPLE_FACTORS           	1	13	Sample source:Mouse EDL muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=13.mzXML
SUBJECT_SAMPLE_FACTORS           	2	14	Sample source:Mouse EDL muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=14.mzXML
SUBJECT_SAMPLE_FACTORS           	3	15	Sample source:Mouse EDL muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=15.mzXML
SUBJECT_SAMPLE_FACTORS           	4	16	Sample source:Mouse EDL muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=16.mzXML
SUBJECT_SAMPLE_FACTORS           	6	17	Sample source:Mouse EDL muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=17.mzXML
SUBJECT_SAMPLE_FACTORS           	8	18	Sample source:Mouse EDL muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=18.mzXML
SUBJECT_SAMPLE_FACTORS           	10	19	Sample source:Mouse EDL muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=19.mzXML
SUBJECT_SAMPLE_FACTORS           	12	20	Sample source:Mouse EDL muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=20.mzXML
SUBJECT_SAMPLE_FACTORS           	14	21	Sample source:Mouse EDL muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=21.mzXML
SUBJECT_SAMPLE_FACTORS           	16	22	Sample source:Mouse EDL muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=22.mzXML
SUBJECT_SAMPLE_FACTORS           	18	23	Sample source:Mouse EDL muscle | Diet:Con	RAW_FILE_NAME(Raw file name )=23.mzXML
SUBJECT_SAMPLE_FACTORS           	20	24	Sample source:Mouse EDL muscle | Diet:SAAR	RAW_FILE_NAME(Raw file name )=24.mzXML
SUBJECT_SAMPLE_FACTORS           	-	b1	Sample source:Blank | Diet:-	RAW_FILE_NAME(Raw file name )=b_231123030648.mzXML
SUBJECT_SAMPLE_FACTORS           	-	b2	Sample source:Blank | Diet:-	RAW_FILE_NAME(Raw file name )=b_231123033248.mzXML
SUBJECT_SAMPLE_FACTORS           	-	b3	Sample source:Blank | Diet:-	RAW_FILE_NAME(Raw file name )=b_231123035850.mzXML
#COLLECTION
CO:COLLECTION_SUMMARY            	Tissues were collected and snap-frozen in liquid nitrogen.
CO:SAMPLE_TYPE                   	Muscle
#TREATMENT
TR:TREATMENT_SUMMARY             	Wild type (WT) C57BL/6J were purchased from Charles River (Freiburg im Breisgau,
TR:TREATMENT_SUMMARY             	Germany). Experimental diets were based on Research Diets D12450J with
TR:TREATMENT_SUMMARY             	approximately 18% of calories from protein, 10% from fat and 72% from
TR:TREATMENT_SUMMARY             	carbohydrates. SAAR diets containing 1.15g methionine (M)/kg food and lacking
TR:TREATMENT_SUMMARY             	cysteine (C) (Miller et al., 2005, DOI: 10.1111/j.1474-9726.2005.00152.x ) in
TR:TREATMENT_SUMMARY             	the context of a 17% protein/ 73% carbohydrate calorie diet were provided Ad
TR:TREATMENT_SUMMARY             	Libitum (AL). Food intake was monitored daily during experiments. The Research
TR:TREATMENT_SUMMARY             	Diets product number for the control diet is A17101101 and for SAAR diet is
TR:TREATMENT_SUMMARY             	A17101103.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Soluble lipid extraction was done by adding 50% methanol:50% H2O and chloroform
SP:SAMPLEPREP_SUMMARY            	2:1 to the samples. Samples were incubated at 4°C (on wet ice) for 10 min and
SP:SAMPLEPREP_SUMMARY            	then centrifuged at 4 °C at 20,000 x g for 5 min. The bottom layer was
SP:SAMPLEPREP_SUMMARY            	extracted using glass hamilton syringes and transferred to glass vials for
SP:SAMPLEPREP_SUMMARY            	further processing. The first extraction step was repeated and the chloroform
SP:SAMPLEPREP_SUMMARY            	was evaporated using a nitrogen gas manifold. Samples were reconstituted in
SP:SAMPLEPREP_SUMMARY            	1:1:1 methanol, acetonitrile, isopropyl alcohol for analysis.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Mobile phases A = 1 mM ammonium acetate and 0.2% (v/v) acetic acid in 90:10
CH:CHROMATOGRAPHY_SUMMARY        	(v/v) water:methanol; B = 1 mM ammonium acetate and 0.2% (v/v) acetic acid in
CH:CHROMATOGRAPHY_SUMMARY        	98:2 (v/v) isopropanol:methanol
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Vanquish
CH:COLUMN_NAME                   	Agilent InfinityLab Poroshell 120 EC-C18 (100 x 3mm,2.7um)
CH:SOLVENT_A                     	90% water/10% methanol; 1 mM ammonium acetate; 0.2% acetic acid
CH:SOLVENT_B                     	98% isopropanol/2% methanol; 1 mM ammonium acetate; 0.2% acetic acid
CH:FLOW_GRADIENT                 	The linear gradient eluted from 25% B (0.0–2.0 min), 25% B to 65% B (2.0–4.0
CH:FLOW_GRADIENT                 	min), 65% B to 100% B (4.0–16.0 min), 100% B (16.0–20.0 min), 100% B to 25%
CH:FLOW_GRADIENT                 	B (20.0–21.0 min), 25% (21.0 – 25.0 min)
CH:FLOW_RATE                     	150 μl min−1
CH:COLUMN_TEMPERATURE            	25°C
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Plus Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	LC–MS data acquisition was operated under full scan positive mode for all
MS:MS_COMMENTS                   	samples. The full scan was set as: orbitrap resolution, 70,000 at m/z 200; AGC
MS:MS_COMMENTS                   	target, 3e6 arb; maximum injection time, 250 ms; scan range, 265–1150 m/z.
MS:MS_COMMENTS                   	LC-MS peak files were analyzed and visualized with El-MAVEN (Elucidata) using 5
MS:MS_COMMENTS                   	ppm ion extraction window, minimum peak intensity of 1 x 105 ions, and minimum
MS:MS_COMMENTS                   	signal to background blank ratio of 2.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	ion count
MS_METABOLITE_DATA_START
Samples	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	b1	b2	b3
Factors	Sample source:Mouse Soleus muscle | Diet:Con	Sample source:Mouse Soleus muscle | Diet:SAAR	Sample source:Mouse Soleus muscle | Diet:Con	Sample source:Mouse Soleus muscle | Diet:SAAR	Sample source:Mouse Soleus muscle | Diet:Con	Sample source:Mouse Soleus muscle | Diet:SAAR	Sample source:Mouse Soleus muscle | Diet:Con	Sample source:Mouse Soleus muscle | Diet:SAAR	Sample source:Mouse Soleus muscle | Diet:Con	Sample source:Mouse Soleus muscle | Diet:SAAR	Sample source:Mouse Soleus muscle | Diet:Con	Sample source:Mouse Soleus muscle | Diet:SAAR	Sample source:Mouse EDL muscle | Diet:Con	Sample source:Mouse EDL muscle | Diet:SAAR	Sample source:Mouse EDL muscle | Diet:Con	Sample source:Mouse EDL muscle | Diet:SAAR	Sample source:Mouse EDL muscle | Diet:Con	Sample source:Mouse EDL muscle | Diet:SAAR	Sample source:Mouse EDL muscle | Diet:Con	Sample source:Mouse EDL muscle | Diet:SAAR	Sample source:Mouse EDL muscle | Diet:Con	Sample source:Mouse EDL muscle | Diet:SAAR	Sample source:Mouse EDL muscle | Diet:Con	Sample source:Mouse EDL muscle | Diet:SAAR	Sample source:Blank | Diet:-	Sample source:Blank | Diet:-	Sample source:Blank | Diet:-
CoQ10 (Oxidized, Ubiquinone)	3879531.25	4993936	2216856.75	5011789.5	4446707.5	1756323.62	4396845.5	4893482.5	167031.94	5774496	6669796	192089.98	610418.81	6122.52	2127718.75	764244.44	963090.31	1013004.75	2159668.25	1235692.75	1013237.81	1748574	1762282.12	0	0	0	0
CoQ10 (Reduced, Ubiquinol)	849293.69	836284.25	288100.94	638687.31	924124.06	1124625.88	728918.31	746026.19	435050.41	747829.94	1105575.62	557615.44	1012303.94	45577.67	1142010.75	965808.56	1089382.88	1054249.12	880949	1130506.75	974487.06	1156448.12	1021162	46080.57	0	4184.86	0
CoQ9	3522010.25	10874964	1728070.5	6449146.5	7216810	127697.66	4356740.5	5796104	35466.59	8525439	10656375	50584.42	349178.41	4511.52	1287845.62	401629.97	2609957.25	1236724.62	842383.31	564652.75	1059443	3293543.25	5006996	4892.32	3649.21	0	0
LPA(18:4)	113255.01	249634.67	74150.7	120067.5	228552.88	53179.46	113203.54	296588.97	2327.56	197976.48	243614.02	2925.09	46655.75	0	57242.36	82912.68	133820.31	159504.36	77691.3	101883.88	67451.53	183159.81	203055.06	0	0	0	0
LPG(20:0)	65012.3	82222.83	6675.71	48553.36	108739.15	6393.59	50111.88	85062.38	2051.71	58702.71	91673.03	3269.85	6210.25	0	6470.46	6113.18	79597.48	0	21911.9	7862.77	15526.37	8444.61	75102.88	2026.23	0	0	0
LPG(20:4)	126218.34	339292.84	74641.77	174564.19	230922.05	74141.05	124542.59	242663.05	3973.36	234419.7	284550.91	14405.59	62406.53	823.24	125563.29	122045.24	215037.33	205288.36	128371.34	127008.35	86905.62	269538.53	307410.03	0	0	0	0
LPG(22:0)	205182.89	238717.8	18682.44	93709.93	311634.19	36398.94	82395.72	209055.25	29562.61	97284.72	325628.62	22961.65	23962.77	4957.81	15277.42	34764.55	225097.17	60705.75	64418.58	22337.38	55928.91	0	247195.77	12905.41	0	0	0
LPG(22:1)	85845.52	143784.95	10664.49	59874.25	188465.5	7728.27	57415.17	82583.71	20990.6	75419.41	173821.23	9983.7	14224.07	0	0	0	75537.45	20941.9	8913.86	9292.44	35562.81	17840.66	93950.25	6165.68	0	0	0
LPG(22:6)	205182.89	238717.8	18682.44	93709.93	311634.19	36398.94	82395.72	209055.25	29562.61	97284.72	325628.62	22961.65	23962.77	4957.81	15277.42	34764.55	225097.17	60705.75	64418.58	22337.38	55928.91	0	247195.77	12905.41	0	0	0
LPI(20:0)	1759453	3061628.75	1575750	2664579.25	2281076.75	280486.34	1819899	1869189.62	230383.58	2861836	3063329	89602.73	327047.34	31254.17	1043892.25	375318.16	992539.81	588608.81	507974.53	384149.12	474779.5	740362.69	1171444.88	40817.21	0	0	0
PA(34:0)	30367.06	124719.19	167461.27	141327.58	123392.02	68053.16	70026.05	93639.38	3341.14	97829.96	354869.84	6063.23	46255.95	2439.3	92187.03	37557.79	89216.88	70261.45	76164.52	61620.5	106207.53	115098.65	161117.38	0	0	0	0
PA(36:0)	44206.46	71408.69	21920.87	70050.69	54771.88	41708.71	65679.24	66665.03	0	93427.57	124679.45	0	9415.45	0	69994.44	71519.71	62151.36	91327.19	35345.45	30820.65	41134.72	171358.7	111222.04	0	0	0	0
PA(36:3)	125220.24	178174.17	277566.41	230597.02	169603.38	103796.96	133742.28	136554.81	0	186412.3	369066.84	0	12930.04	0	34004.69	6737.93	26636.15	20779.59	85791.04	41781.25	15603.01	38312.84	51412.98	0	0	0	0
PA(40:0)	37203.5	75477.28	30279.34	98485.35	66833.65	8752.36	60816.34	110418.02	0	122238.87	83191.73	0	21223.97	0	59948.55	15771.52	127838.82	5659.47	11314.21	49789.38	24488.69	10792.77	108771.41	0	0	0	0
PA(40:4)	102831.49	203998.55	84405.55	165226.88	181176.14	16802.97	138189.14	120864.96	11129.32	126807.79	66352.73	2213.46	194139.98	11003.4	480970.09	241820.62	453578.59	338268.78	159646.89	237160.8	259629.33	296641.69	516591.84	6776.23	0	0	0
PA(42:0)	216896.33	358378	209071.33	356914.38	352487.84	66568.07	365838.66	268356.34	40469.92	373513.16	421384.62	61312.53	318286.84	60962.04	602206.69	273101.78	672069.06	423361.47	380774.41	298028.75	469730.47	280112.72	586325.19	51843.22	8169.56	16027.66	4614.51
PA(42:10)	16018.95	57558.14	24289.39	70282.89	72742.52	9405.47	42535.79	88302.37	0	57369.28	92316.4	0	2471.13	0	28861.37	24914.81	72274.59	70087.96	18234.61	41709.43	8824.2	60966.17	87255.19	0	0	0	0
PA(42:2)	55709.06	84835.53	34766.17	106353.48	72963.09	4873.19	61210.32	63454.16	3981.68	71789.7	80565.34	4247.76	4653.46	0	8822.88	6680.01	19707.9	6183.78	0	5497.23	11345.35	15664.95	24557.87	3320.9	0	0	2232.25
PA(42:4)	773648.56	872318.31	633650.19	1112278.38	902856.81	140231.42	748506.75	860576.19	80068.48	856587.5	959041	29653.06	1002078.5	75921.03	1468809.62	1035768.69	1562237.5	1286871.25	981210.75	1110328.38	1323811.38	630386.81	1804556.88	75843.62	0	0	0
PA(42:5)	219276.42	212933.86	157704.83	272795.66	233616.17	37714.71	215085.27	241064.14	25834.96	270481.5	280302.31	15474.18	581812.31	30624.14	930674.25	533950.88	959402.5	727717.06	542648.56	568433.88	650614.81	643577.19	977769.31	45999.27	26169.32	13249.5	11225.95
PA(44:10)	239549.92	383684.12	131910.33	292495.5	230529.7	0	323213.97	227633.17	10275.97	219973.61	310164.16	0	206256.62	22714.96	504066.62	337719.41	608087.5	496953.78	414124.59	401631.66	362992.28	551816.94	824600.81	11630.2	0	0	0
PA(44:2)	117042.31	219085.27	63901.1	118729.99	157039.95	0	106684.72	97459.3	4671.56	129873.05	223274.12	4407.67	20829.38	0	68699.91	52069.36	103491.91	99730.6	75690.11	13191.67	72834.6	135138.28	160039.23	0	0	3827.78	0
PA(44:3)	468000.72	805347.69	243018.36	449197.53	603567.38	33917.67	494366.09	300724.59	43389.63	486298.38	876302	16294.64	105273.38	10233.48	341335.25	212411.19	396115.88	340422.22	232264.33	90675.76	256150.39	457990.88	603614.38	22479.03	3727.87	4173.77	3390.46
PA(44:4)	115335.12	243809.8	126083.82	137851.42	115088.09	92266.09	196436	197371.75	53156.43	133767.92	151016.77	6308.91	248348.39	11323.79	408085.78	302820.84	275632.59	370764.53	210451.2	335897.72	370251.03	129308.9	349546.47	13631.79	0	0	0
PA(44:5)	453369.84	329425.09	355224.5	531413.94	551296.25	246656.45	515147.53	345163.44	218457.77	607801.31	386837.16	69209.12	1035740.06	205390.19	1014775.5	758076.06	1070624	948499.81	693743.31	1099507.62	1165235.5	734137.81	1085905.5	160468.27	0	0	0
PA(44:6)	587918.19	784798.81	523459.75	781098	678461.56	126861.75	501378.38	645546.56	89601.59	777734.25	911675.31	20092.52	983422.81	101676.82	1422321.62	785094.31	1887214.38	1278291.38	889240.94	898371.81	1187985.62	938889.31	2030348	64935.45	2380.3	0	3026.9
PA(44:8)	71460.95	129683.44	64423.24	115761.98	101405.66	4626.04	119400.18	96659.66	10419.71	101505.2	152764.64	7583.69	57100.61	18855.54	109906.1	36246.93	153700.8	93897.91	73110.97	22062.19	101901.02	71771.09	145662.08	9621.96	3169.49	0	8892.95
PA(44:9)	11475.4	51709.8	9937.86	5149.66	55223.67	0	19915.57	25477.59	0	3723.61	74763.87	0	0	0	67731.53	38882.5	0	76241.71	73792.24	40927.25	30022.36	74481.68	150861.06	0	0	0	0
PA(46:0)	893572.31	1257125.62	9718195	1295627.12	1198620.5	66365.78	766689	1492728	168394.62	1257509.88	1653904	5000.67	478340.41	22325.69	1834860.5	437620.34	2263254.5	804031.69	2015806	458266.91	791320.31	1275384.12	2267827.5	219372.69	0	0	0
PA(46:10)	746368.5	1398353.62	404810.34	947782.44	839045.69	16493.47	787817.94	959558.81	41586.2	959820.19	961413	3774.42	335041.25	40420.39	816248.69	484045.75	873175.81	620320.06	650629	530845	524640.31	906842.44	1305656.38	18651.93	0	0	0
PA(46:11)	318206.72	548457.44	85041	130353.75	589663.75	93076.99	299414.91	303362.66	39542.36	168765.89	886875.19	0	88586.34	24079.4	701572.81	501351.62	947249.69	1344826.38	842185.25	708849.69	811794.69	1246654.38	1485968.12	33860.72	0	0	0
PA(46:3)	746630.06	635162.06	2638417.75	668617.69	862373.06	86240.62	812348.19	923973.75	166746.16	835825.19	1131503.5	26887.76	304225.38	47378.7	759032.56	287126.09	966770.44	491322.91	909491.31	336718.78	476943.59	580430.81	950276.81	132061.53	11598.24	4814.2	7475.55
PA(46:4)	1051790.62	1145264.62	6876086	1512690.38	1065535.62	113516.21	734973.69	2011028.5	180844.58	1399526	1197608.62	8735.03	917327.25	85987.48	2734705.75	1613922.88	3821847.75	2433793.75	4167758	1439587.62	1454861.38	4958587	3670100.75	306667.47	2506.55	0	2767.66
PA(46:5)	646020.94	701770.31	2109558.75	555775.94	712725.75	178830.95	552530.31	533461	154902.23	570027.19	753558.06	54178.09	1102482	136441.05	1557562.88	891421	1843797.12	1269276.12	1031926.69	1025480.56	1249239.88	808837.69	1773572.88	107824.23	0	0	0
PA(46:6)	775227.25	1012711	798947.5	950402.94	984000.44	211068.25	783396.31	890990.31	191662.25	1009960.19	1101527.38	54593.57	676048.88	134844.89	927899.69	659250.06	1164136	985238.81	583804.38	718231.5	886061.75	875615.81	1161704.12	68163.08	0	0	0
PA(46:7)	439676.62	540734.94	343130.53	503325.09	474011.22	80751.62	360452.38	445263.09	67997.14	493528.72	653363.44	16165.47	419525.34	53103.21	628340.5	357287.09	786373.94	528322.44	375543	408493.91	606172.06	375636.47	968154.69	28722.98	4611.69	4554.81	3879.97
PA(46:8)	310665.12	360774.59	204577.45	349113	342613.97	68933.13	290022.59	240022.98	51428.84	325629.34	358344.78	16278.39	676171.69	69575.02	914378.75	626448.88	1127334.38	840691.75	652158.44	570219.38	869502.94	731504.81	1343068.88	27975.35	0	0	0
PA(46:9)	148544.14	258582.98	86743.23	82182.84	261630.92	47587.41	148750.3	163521.58	6892.14	148695.23	449635.97	0	48316.41	4274.35	187115.19	101828.52	245403.77	211876.52	157104.3	112613.16	181015.8	298351.34	412901.09	0	0	0	0
PA(48:1)	1561324.12	2067587.38	10995672	1587031.62	2007987.38	119237.68	1395571.5	2745560	255233.25	2036382	2733957.75	3796.05	1141850.88	120022.87	4135165.25	937716.25	5538218	1633625	5323793	1353676.12	1830375	2816951.25	5174633.5	479017.59	0	0	0
PA(48:10)	2393487.5	3672083.25	1571918.88	3756322.75	3046648.75	455274.25	2587421.25	2598870.75	381319.25	2822625.75	3573180	166251.17	3121134.75	232468.08	4461755	3004123	5106955.5	3892393.25	3079862	3364500	3978723.25	2976229.25	5576240	217531.19	0	0	0
PA(48:11)	1280933.5	2224058.75	399884.34	604916.38	2257806.75	397544.66	1024048.75	1386424.62	152796.67	930973.44	3592158	41703.17	249495.23	57282.11	1514931.38	747050.44	1809927.62	2020530.62	1206376.12	1176446.5	1307771.62	2758858.75	3463756.75	66850.06	0	0	0
PA(48:12)	216933.48	367151.16	47516.88	92744.81	369047.28	53594.72	177916.8	205698.38	17179.08	145210.8	538957.81	2594.23	53922.33	12400.09	303534.12	280911.44	440460.22	571402.44	451627.12	286990.16	363810.38	587952.19	774784.31	10850.14	0	0	0
PA(48:2)	430737.41	609643.81	3904038.75	736837.06	446113.41	9526.52	320034.22	740528.94	59267.22	531320.69	602818.06	0	180175.25	21765.27	721178	170035.23	938629.69	338064.66	905518.31	254823.05	299141.88	476958.78	1073284.75	77461.27	0	0	0
PA(48:3)	367996.62	416248.28	1771034.38	510561.97	395265.09	34538.95	382150.62	558204.38	50889.72	411827.62	556231.38	11204.92	175502.3	33437.22	627993	191563.17	731627.94	333133.72	691880.19	195323.95	278679.5	441705.78	836269.5	81796.46	16108.71	11253.32	3572.63
PA(48:4)	2569375.75	2905991.25	12034291	3444771.75	2594071.75	171736.67	2054858.62	4162702.75	434906.16	2840893	3377164	16819.39	1600884.38	184278.2	4892694.5	1596512.38	6172506	2936018.75	5318071	2106070.5	2807532	3953014	6070860	548826.06	3023.98	0	2992.67
PA(48:5)	991424.69	1117872.62	8614465	1356422.62	1025494.06	80354.87	698015.94	1801770.88	137680.2	1091624.5	1159508.38	22712.84	709821.69	71881.02	2628998	1261398.62	3739361.25	2135035.75	3991485	1104675.38	1316162.38	4211202	3390741	187156.94	20342.04	15948.87	22223.83
PA(48:6)	745677.69	833764.69	567284.69	701951	860158.69	122273.16	655651.81	695458.56	144844.17	674901.94	881298.25	0	266402.16	0	319470.34	213357.73	489234.25	289968.97	239550.58	196410.12	320637.41	372174.66	527864.88	0	0	0	0
PA(48:8)	606796.25	670845.5	404051.09	632495.44	660589.88	149285.83	751307.94	635811.19	148075	719638	680372.19	40118.42	656789.56	95828.37	907635	586460.69	894575.5	961646.75	613009.94	689431	840086.81	806756.19	974294.31	60435.77	0	0	0
PA(48:9)	395413.5	439714.72	241439.08	410987.09	472782.09	82067.97	384041.25	372410	64143	403712.34	567516.19	12173.4	710298.06	60265.12	1063407	589504.81	1092931.38	888074	675217.44	715456.94	915141.44	486357.41	1392635.75	39727.53	0	0	0
PG(30:0)	65187.39	115464.41	48196.64	110628.69	115538.54	31397.34	68897.59	99363.96	6579.13	157062.52	132324.06	1854.13	130027.41	8136.27	225836.95	114236.28	353080	150821.39	144995.44	130384.85	195474.64	178297.75	381357.41	1953.12	0	0	0
PG(32:0)	592228.56	956951.19	376260.09	799563.25	1112637.88	269099.72	676670.5	792911	74660.37	1305230.88	1403647.38	42104.03	684322.69	34018.39	1107142	583530.81	1947544.88	864534.81	864277.31	691427	1108457.5	837014.81	2171168.75	30401.46	0	0	0
PG(32:1)	191897.64	286529.09	126626.06	247284.62	299955.22	73385.32	206931.56	278662.12	15324.96	345436.34	372909.22	8040.99	326484.28	16191.08	558290.25	267344.25	975627.5	341138.25	375026.25	241061.45	553830.94	444309.41	1111910.88	8034.24	0	0	0
PG(32:2)	12352.32	36239.65	14418.64	32455.46	23151.15	0	13514.2	23120.76	0	45723.83	35763.86	0	14351.95	0	35845.41	11754.61	69174.26	30794.59	22972.54	17065.47	39785.25	46129.84	71833.77	0	0	0	0
PG(34:1)	16055727	24055274	9270397	20021802	21996918	3821469.25	15309665	17736410	1612593.38	25566534	24626026	1108126.75	6754625.5	574886.81	12287243	5705966.5	21493842	8204276	8234077.5	5237818	10122871	8886934	19762442	339369.5	0	0	0
PG(34:2)	2260605.75	3394717	1644833.62	2506603.5	3045703.25	649097.19	1947767.62	2816662.75	272233.53	3906832.75	4469997.5	163681.5	1198294.25	111866.85	2367859.25	1054968.12	3974602.75	1563093	1415523.5	982031.25	2033915.38	1664799.38	4060809.25	62276.79	0	0	0
PG(34:3)	52648.57	188040.05	63169.04	118747.52	97604.62	19945.72	68664.99	104318.91	2207.92	120856.48	144042.14	5025.16	66589.73	1561.37	132199.64	66743.89	309710.5	127646.15	106407.37	75970.16	168537.08	134581.52	357428.75	1406.18	0	0	0
PG(36:0)	8504837	12913987	8843883	12058501	10932499	1172082.62	8505093	10356791	1237822	12499165	13065040	327611.84	5088725.5	434976.28	11820907	5679044.5	12490312	8333001.5	6729898	5514635	7700720	11261893	15852071	393554	0	0	0
PG(36:2)	1489840.88	3265455.25	1230782.5	2365049.25	2883348	413170.38	1354823.62	2005062	209029	3223949.75	3865868	162143.94	613404.94	75129.97	1506170.5	713383.06	2416139.5	1039596.81	731595.75	599830.94	1218750.88	1668934	2734354.25	53579.97	1121.15	0	0
PG(36:3)	479720.22	1640555	548947.38	1192617.5	954760.19	157519.11	656507	816592.06	71123.75	1090040.88	1339276.88	46248.05	309503.25	28315.48	543835.56	280935.09	1230829	523956.25	317919.97	221833.45	618678.75	820851.81	1468114.62	27012.57	0	0	0
PG(36:4)	148573.7	804639.75	243211.67	508787.66	359839.22	51201.29	247363.36	290742.38	36731.38	342377.34	489605.38	11854.11	103875.01	14560.84	176403.3	107283.22	398704.28	198426.61	136106.14	65842.45	251752.45	231087.67	479071.47	11118	0	0	0
PG(36:6)	152092.23	585221.81	123646.28	349764.25	422496.66	75582.33	169884.86	590205.69	0	473802.09	587349.19	0	40465.02	0	164554.11	100438.47	332619.47	226348.86	113445.59	187142.69	91894.06	240698.02	444529.72	0	0	0	0
PG(38:0)	754779.31	1476633	645383.19	1185377.88	1063497.5	83359.59	738627.31	1022003.31	117153.38	1055233.38	1258578.12	3903.26	257356.52	7724.94	702996.31	342622.5	852610.94	572103.44	384073.41	353381.25	591394.5	741276.44	1111466.88	0	0	0	0
PG(38:1)	3504413.75	6720525.5	1868290	5787474.5	5396521	485494.75	3378658.25	5019949.5	486073.12	5069449.5	6181078.5	153983.62	1565168	151916.83	3472924	2104828.25	4673077.5	3380242.75	1904710.5	2084291	3251975.25	3945471.75	4966312.5	112345.78	8701.49	5170.39	8653.95
PG(38:5)	94322.35	205700.94	54761.29	155422.05	184433.45	33984.19	104968.75	101525.56	2426.89	147462.42	177771.14	0	183235.19	11450.23	240415.7	140282.2	584950.06	211634.86	265388.53	132226.55	413214.91	185350.39	517580.59	0	0	0	0
PG(38:6)	196676.98	374441.34	129511.8	365401.62	313402.75	57405.49	191500.11	197316.88	31452.6	337447.97	371805.53	23585.63	161637.22	15130.43	249402.67	167981.64	505386.25	91746.41	274759.62	176462.75	453577.75	188937.36	568624.31	2261.35	0	2141.11	0
PG(38:7)	45263.25	129817.1	64231.24	146134.39	130837.27	4402.24	94311.49	127691.77	2279.07	168259.55	117180.12	0	26719.02	0	64504	34240.37	100673.59	52865.38	53764.86	18554.67	54292.33	55538.11	84631.18	0	0	0	0
PG(40:0)	110147.9	91223.18	56582.32	162718	121824.56	30092.29	197849.7	134669.89	32124.31	182314.5	155226.36	4222.38	53524.59	0	22872.49	9377.84	29176.71	10172.05	7168.29	21850.09	21122.45	26369.97	16485.62	0	0	0	0
PG(40:5)	26471.05	17147.45	0	15340.54	5760.84	0	13180.32	18698.69	0	3987.99	11457.66	0	44049.3	1964.3	117922.13	65886.21	82973.48	73396.3	59062.8	57290.59	48027.64	130386.91	144431.67	0	0	0	0
PG(40:7)	707860.56	1452800.38	580979.5	1175689.25	1537276	154895.89	889874	548921.5	73230.83	1413356.5	1562747.62	41283.29	331109.34	34821.34	740405.69	427567.34	1252876.5	523944.66	573119.56	333956.97	675631.44	715825	1359247.62	10027.86	0	0	0
PG(40:8)	471493.5	1302178.5	434723.59	923179.81	898944.56	95907.56	586138.62	637982.81	64706.94	893383.19	990455.06	28776.16	182718.48	23208.13	389845.47	269157.22	760264	357917.09	341953.91	215214.38	502049.53	424471.09	727605.56	4995.44	0	0	0
PG(42:0)	280870.34	205287.8	766251.5	361634.59	189775.36	141750.19	347222.19	334211.12	5950.53	392822.59	452834.12	0	11225.27	0	121923.54	34956.61	46438.77	46975.86	242091.62	75291.94	47662.89	77892.47	55725.83	0	0	0	0
PG(42:10)	133631.92	172667.36	75667.48	130932.43	220894.42	21606.9	140608.09	129556.5	11041.53	177004.8	213939.8	3931.38	46387.07	2045.34	109585.48	57514.66	191796.39	81941.99	77045.91	42799.37	93752.57	86610.09	179834.8	0	0	0	0
PG(42:5)	115752.81	153251.41	81482.47	83260.63	98781.1	0	100091.75	96090.74	2280.16	81221.9	139251.17	0	158585.56	11090.56	355673.84	150459.77	327409.91	240206.86	245430.42	127911.23	238355.55	291090.03	470671.34	2176.91	0	0	0
PG(42:6)	424305.03	481553.78	250802.58	333662.91	411223.03	0	470973.16	429623.16	28301.1	356129.25	595927.06	0	502433.84	55851.64	1304741.62	622876.56	1316094.62	954457.94	651092.5	645717.88	866391.5	1091986.12	2197338.75	30105.9	0	0	0
PG(42:7)	64366.48	79442.72	41742.24	57121.3	47582.57	0	69372.23	65237.88	1309.11	85626.09	77544.74	0	45830.38	2520.56	101101.21	75597.79	135050.06	91906.49	82202.47	72820.16	82057.13	114433.75	178046.5	1980.71	0	866.9	0
PG(42:8)	64455.64	65168.05	54445.3	100180.21	80262.27	2965.41	65800.3	64108.88	5300.75	103684.48	72735.34	2112.5	167021.66	6057.48	344363.25	174138.66	272624.53	201238.08	189700.23	156198.06	177774.14	200701.36	273849.41	2420.58	0	0	0
PG(42:9)	49054.71	98330.88	33421.79	64187.49	83655.05	9117.91	61655.21	50684.8	1439.5	73011.27	115625.19	0	20200.4	0	62046.34	27296.23	68955.52	32969.26	39539.32	24681.9	43456.48	40320.21	102627.94	0	0	0	0
PG(44:0)	1209885.25	1184998.62	602063.5	1086060.75	1246823.62	1531218.38	1145075.38	1195854.12	217902.08	1219174.5	1021718.5	273449.16	656760.56	40518.67	1259118	728781.81	766601.19	842166	1324491.12	1268178.25	795136.25	998116.69	902826.69	19328.63	13654.88	29523.52	19202.28
PG(44:11)	40313.32	184798.95	108390.62	171179.05	144322.69	23078.17	159145.75	136407.47	16871.99	212216.17	178002.02	1667.43	35775.2	3434.87	113510.15	44825.8	125398.97	68410.26	94222.12	47389.14	82944.06	82885.48	154090.45	0	0	0	0
PG(44:12)	575218.12	1171431.12	566303.56	941009.69	1366500.38	85895.55	878385.44	860909.44	81884.91	1191262	1061477.75	22005.91	198837.88	23765.83	614505.81	336386.78	932859.25	430721.09	551695.31	317585.47	532293.25	446044.47	815947.19	3486.62	0	0	0
PG(44:6)	285711.62	373101.41	215200.8	282289	315244.62	1818.8	346912.22	281672.91	5814.09	316756	463620.59	1846.14	71701.8	11099.13	196250.45	95057.6	228862.8	158992.31	105957.28	102623.68	105557.81	234040.38	357902	1494.3	3292.77	0	1683.06
PG(44:7)	129332.5	151905.38	127004.29	94995.79	159684.77	8568.56	138203.56	133970.67	25354.62	154690.27	205514.81	44522.82	79831.63	18901.08	172555.8	98102.62	220198.58	104924.52	125313.3	112717.32	130582.45	143253.25	304668.12	10569.24	8761.73	11305.76	6706.38
PG(44:8)	157438.27	195958.92	84452.59	113199.52	175906.61	13554.5	223484.08	110483.8	9511.55	150997.73	216232.23	7362.65	248576.7	21324.04	590554.19	296867.03	668809.5	432427.09	358168	355230.75	379137.03	524586.81	833808.25	10966.18	6152.56	13231.6	12459.53
PG(44:9)	149755.39	142406.8	174058.77	158900.42	147589.02	31705.85	151491.05	181128.8	27024.78	203273.3	171039.86	7989.36	205376.7	27256.66	281818.03	215163.05	275809.94	238634.7	228763.11	194625.39	228176.55	237267.08	310488.22	19140.95	0	0	0
PG(46:0)	893275.94	868012	398031.09	761007.69	972552.19	1380159.62	766522.19	804774.06	795114.56	726213.25	494058.28	1081815.5	1465306.62	127146.4	1335159.88	1626949.62	1444784	1474128.38	1149661.75	1535513.38	1547424.62	1406355.38	1488383.38	87529.06	0	0	0
PG(46:11)	52644.8	43033.82	20204.12	60933.82	39595.82	7042.08	64633.19	23678.9	2737.36	60140.27	29896.21	0	120065.81	6481.22	142250.38	89140.9	144712.98	152589.56	77764.5	103169.59	133878.14	96135.04	153149.23	2224.38	0	0	0
PG(46:2)	830329	700437.5	692745.81	919657.31	732165.94	825348.44	899265.5	833709.94	42864.25	862622.81	936610.75	78040.1	189834.42	6361.27	578299.94	308414.78	197179.25	300754.84	763316.5	581137	272238.03	420855.91	345682.47	0	0	0	0
PG(46:3)	252248.94	206767.94	698417.38	271260.97	165566.45	82093.81	351106.5	249544.42	0	254258.55	326204.88	6275.79	64056.86	0	183735	78098.52	58271.92	72938.23	291991.41	106155.54	71542.52	91063.52	23363.51	0	0	0	0
PG(46:9)	91485.3	126307.06	52799.02	96277.15	72855.65	0	121395.54	81106.16	20575.53	76281.74	107585.76	11890	128736.24	17747.55	310293.66	203818.31	285626.72	237513.27	205015.06	190067.92	205743.48	334701.62	379039.09	29354.89	2652.5	6496.1	7873.21
PG(48:0)	441884.84	415182.25	261593.08	453695.53	428062.97	579568.69	405451.47	441828.28	275627.59	381564.09	268739.53	381411.72	510598.5	51500.54	604330.69	565946.31	569957.19	502561	568462.12	674690.56	550080.69	626186.69	566927.69	45528.97	0	0	0
PG(48:10)	642880.44	1132743.38	410648.16	870742	692912.69	58992.67	840023	728376.56	21007.78	785264.94	809440	18326.25	89323.84	43314.67	227866.39	152869.39	219344.17	231584.83	169100.06	185440.25	161070.42	245851.7	280871.62	17458.76	0	0	0
PG(48:11)	71445.79	98890.4	36663.13	81852.66	80288.13	0	93723.56	58510.62	1684.32	78108.37	56061.14	0	25397.19	0	64320.19	50257.83	75860.12	42783.44	56291.43	47030.23	44030.41	94380.34	111211.29	4424.72	0	0	0
PG(48:12)	81237.19	118866.41	52929.49	114399.77	69093.22	0	75565.23	92044.94	1937.22	95078.1	102498.8	0	17638.25	0	46366.77	17690.58	47443.3	31647.93	40148.79	43142.36	31260.82	60455.28	75485.25	0	0	0	0
PG(48:3)	76445.03	63152.47	129583.21	196841.95	46803.56	0	132721.64	74917.53	0	97414.09	173149.48	0	0	0	23548.57	0	5069.93	5512.3	17676.46	13137.21	9758.95	25037.94	10353.73	0	0	0	0
PG(48:4)	419826.97	363332.47	262080.77	389098.75	294237.88	219996.38	558255.62	416727.22	11968.52	381605.34	235578.67	14793.86	121509.53	4157.86	360876.91	193745.05	96993.5	210561.62	532972.81	262702.69	196922.83	215970.69	153512.11	0	0	0	0
PG(48:5)	63333.61	45804.98	264492.72	113771.56	34682.7	12415.5	143491.7	106323.27	0	108462.19	51824.84	0	0	0	21609.91	5813.9	0	7465.64	102054.12	7285.27	6345.12	8477.83	0	0	0	0	0
PG(48:6)	132827.17	137818.27	94921.19	103719.84	150085.42	46443.89	125396.41	150781.7	50975.89	161460.52	173927.06	9428.21	85286.35	11533.91	123498.73	73763.63	144919.59	80967.02	72474.1	64159.06	116890	91103.79	132142.95	5321.5	0	0	0
PI(32:0)	194521.27	239009.89	142092.39	200121.5	171638.2	62293.39	163088.73	187731.08	31579.63	273421.91	187930.38	42172.73	133320.8	2331.7	138768.48	49870.11	230698.98	90492.09	76984.27	52144.55	169417.39	118022.06	154121.05	18681.19	0	0	0
PI(34:0)	11122561	15384847	8457449	18435936	13750465	1665192.38	13796103	11316131	1524320.12	16058904	14374484	551038.12	13118047	725579.44	25362240	15051936	20793382	18211138	15708907	15090523	16987464	16116477	25625480	653246.62	0	0	0
PI(34:1)	8262762.5	13754191	6040988	8131662	10516021	2087339.38	8383444.5	10124064	1069129.12	9779867	11601596	687320.19	4958803.5	532319.06	9455499	6503220	13149428	9644647	6907324.5	6244210	7190781.5	8551748	12882491	473629.72	0	0	0
PI(34:2)	96843.27	201871.25	182391.23	160027	191090.42	40045.69	193349.39	149565.38	20458.13	343423.38	293700.78	20358.09	217888.56	21491.25	311888.59	248255.27	353187.78	324758.91	273243.72	188153.12	162251.42	341155.56	477584.34	18587.78	0	0	0
PI(34:3)	35082.79	114409.71	55311.43	53188.87	50377.18	22564.46	70661.47	58901.02	2106.35	72030.66	108492.31	4322.15	64938.61	1280.37	109927.15	83860.09	213450.67	136594.05	77706.62	63260.76	108872.62	83518.04	112142.16	1962.6	0	0	0
PI(36:0)	107223944	132929088	105742248	119259744	119180232	56056256	117712536	117105792	49897488	120435936	117252008	22394624	109872160	31389110	123599752	110972344	124221640	117435968	115937944	115722216	123590248	110862912	130317816	27609650	0	0	19527.21
PI(36:1)	18897900	21646608	12771888	21046712	22833178	3567709.25	21032586	15463933	2610641.5	21218502	20203722	1050834.5	26210142	1797672.12	39560076	23414986	39437772	27544410	28574302	23916714	28757776	30890202	41056512	1687720.88	0	0	0
PI(36:2)	3949304.75	6660580	3174687.75	5359762.5	5213877.5	1009009.31	4004972	4822352	622638.19	7382406.5	5958658	496497.62	871793.44	101456.6	1529503.88	815822.19	2363451.75	1058832	824812.81	620145.31	1241865.88	1601709.12	2164490	69792.77	0	0	3355.97
PI(36:3)	210176.39	464265.16	189171.69	293832.38	351553.5	96174.43	230609.05	225235.89	0	396813.53	416987.28	9722.25	113722.38	0	202268.31	130025.46	308960.09	162183.73	168694.27	68966.49	194692.8	192594.2	279093.97	0	0	0	0
PI(36:4)	303454.97	555266.62	411762.66	419009.84	493316.75	235634.95	390888.78	488016.66	59362.37	540565.5	812292.81	36589.43	163075.14	39975.34	317257.06	245272.8	642660.31	185955.56	166229.11	184231.58	277493.22	320925	589974	21298.83	0	0	0
PI(38:0)	87611056	100051968	83776648	105208904	97267848	31577306	97744704	100238592	37927156	99804088	94498712	17449872	36531600	5678796	58772044	43338976	59076108	59217700	49115948	45569292	54068864	55756844	62200832	4629991.5	0	0	11396.7
PI(38:1)	18026208	22101790	14351607	17754986	18561144	4906993	19586828	15399948	4480614.5	17536520	19097102	1722687	9513233	1708366	11707704	8070904.5	11833345	10080823	8494056	9279893	11908003	8766012	13611827	1498889.62	0	0	0
PI(38:2)	47274716	59540364	38856816	54079028	55882460	7653716.5	48020000	49275860	7590294.5	52579328	56534288	2890106	17887110	2193653.5	31751282	17965866	30863254	24574790	20541474	19882342	27524950	24837328	37549252	1706859.62	0	0	0
PI(38:3)	3389034.25	5439834.5	2845200	4584435.5	4180246.75	1359580.38	3760478.75	4090868	479535.75	5568755.5	4836158	393501.72	2825477	264291.28	5121588	2861937.25	6535589.5	3857008	3313461	2609600.25	4100481	4186714	5834918	193766.2	0	0	0
PI(38:4)	15252941	24336482	12752967	19540600	19742518	7990136	15985203	18092622	2381476.5	26375608	22956728	2506721	13232751	1191615.5	21496024	11004466	30992394	13204464	11944611	8893159	16856386	13451975	25446298	938111.31	0	0	0
PI(38:5)	781605.19	1082330.38	866874.69	839846.25	883344.44	619550.31	626673.19	665504.5	92556.62	1018896.94	1252345.75	125211.07	818902.81	67692.09	1347333.38	630919.5	2255148	721749.5	802707.31	406747	1040852.5	638623.69	1930039.5	50034.28	0	0	0
PI(38:6)	86121.36	578303.12	53565.56	235316.27	294130.03	88060.12	191561.67	343888.84	37308.31	267997.28	287624.53	29167.57	489365.28	53673.98	857760	632699.19	1242078.75	712603	842481.69	408862.75	915871.31	650184.06	1330242.88	21599.29	0	0	0
PI(40:0)	1499379.38	2541715	903026.5	1227808.75	2118187	274159.25	1641744.12	1286940.5	353923.47	1405318.5	2585349	53749.34	190120.11	25412.83	370748.22	163004.69	465367	318915.03	229892.89	160555.86	380887.75	324349.75	651911.38	11686.49	0	0	0
PI(40:1)	828575.06	1121642.38	539666.25	909137.06	970413.5	212317.5	927562.31	731375.19	299003.41	551550.38	1005888.81	71176.07	251000.75	24690.73	354269.28	254072.55	427387.97	354025.91	298741.16	320061.75	422978.25	177235.05	460384.78	23301.38	0	0	0
PI(40:2)	934994.31	1867788.12	448981.91	848684.06	2141648.75	155189.55	1202971.38	1487621.62	139581.3	607291.25	2233589.75	50986.42	77830.29	14139.44	1387276.62	327726.25	1669286.88	1199597.88	754049.19	631389.69	699786.31	1548179.12	2221341.25	4633.3	0	0	0
PI(40:3)	846384	1234504.38	678355.25	915528.94	1076327.62	228761.55	1051422.12	828125.69	184255.08	812919.69	1152707.88	61597.06	285831.03	36264.32	385335.25	310344.59	541745.94	457146.66	387820.53	424273.75	408116.72	419787.5	634410.31	16767.32	0	0	0
PI(40:4)	2628995.25	3721920	1898976.5	2737497.25	3330982.75	443542.12	3034654	2534331.75	422886.59	2779009.25	3434106.75	142373.45	1032275.44	95989.15	1739649.12	995518.44	1632677.12	1277531.12	1120816.12	1083673.62	1613352.88	1212026.12	1843602.62	73901.18	0	3542.34	0
PI(40:6)	6371251.5	11103171	4934054.5	9920231	9379340	2772574.75	7332745.5	8327932	1067326.88	10387571	9219337	1043429.19	6234012	490381.91	10995903	6271982	16691544	7513157.5	6960455.5	4932317.5	9647145	6923157.5	13536404	457043	0	0	0
PI(40:7)	164998.56	236665.88	95125.5	197910.7	219821.56	56908.38	158728.61	154326.8	24060.82	195006.95	232901.06	15415.31	256271.7	14432.41	295365.91	161577.36	610752.75	210647.44	194368.81	157916.69	302648.38	217315.08	503250.25	11229.03	0	1351.45	0
PI(42:2)	96585.24	108817.53	129309.99	113544.46	112404.75	35565.58	115963.1	94609.24	22610.66	129357.46	95616.79	0	57254.99	0	59384.32	43099.95	49279.91	37552.46	28926.22	49566.37	52424	30855.6	81360.7	0	0	0	0
PI(42:4)	99420.41	62426.21	44156.08	44398.27	97276	0	40724.55	9422.92	17020.59	43857.92	119031.62	0	59342.55	0	93292.55	29838.6	111286.26	62416.54	50557.85	48435.42	109906.23	40167.32	0	14227.85	2542.65	0	0
PI(42:5)	412659.62	527291	350580.78	568004	584987.12	69264.9	530420.25	388469.12	71646.68	542755.56	557347.25	22465.81	589891.75	34070.8	1020646.56	774228.31	833630	808419.94	703637.25	682369.75	919139.94	517721.59	809317.31	51499.93	0	1552.91	0
PI(42:6)	1899448.5	3599098	1990723.12	3117251.25	3309688.75	247310.11	2886396	2400692.75	337606.56	3163839.25	3024204	111068.52	570135.5	45742.94	1099913.12	708456.5	1006702.56	893491.81	894192.69	797268	1018893.06	709097.69	1106887.62	37458.65	0	0	0
PI(42:9)	69002.09	64774.47	54369	58682.78	87868.78	68156.31	53986.13	18891.16	82024.98	53101.09	22365.41	22736.85	96449.29	37179.58	93407.21	90212.19	57901.15	119711.35	53381.17	61323.92	91011.46	32516.05	55475.49	4663.58	0	0	0
PI(44:2)	30806.62	78904.11	28670.94	43494.21	113562.98	22956.76	61157.26	57357.45	5267.97	84283.35	23578.01	0	30242.38	0	34687.31	14824.16	53529.11	49995.64	18841.03	13652.5	44754.75	35913.93	69117.7	0	0	0	0
PI(44:3)	68389.01	116895.15	77532.68	60693.42	122908.75	43183.71	60734.26	103388.69	40674.75	61052.06	96682.78	0	73168.09	0	86598.78	61562.31	90584.19	60457.61	68537.91	69566.62	80072.33	97630.16	82972.53	0	0	0	0
PI(46:12)	177347.56	439928.66	70347.45	207752.77	155067.5	75360.27	189714.75	288077.97	0	348034.12	383654.88	18434.72	102264.34	1800.35	287619.91	214813.11	460471.5	286139.38	199600.27	249178	206454.2	400470.25	662318.56	0	0	0	0
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	Formula	RT
LPA(18:4)	C21H35O7P	NA
LPG(20:0)	C26H53O9P	NA
LPG(20:4)	C26H45O9P	NA
LPG(22:0)	C28H57O9P	NA
LPG(22:1)	C28H55O9P	NA
LPG(22:6)	C28H57O9P	NA
LPI(20:0)	C29H57O12P	NA
PA(34:0)	C37H73O8P	NA
PA(36:0)	C39H77O8P	NA
PA(36:3)	C39H71O8P	NA
PA(40:0)	C43H85O8P	NA
PA(40:4)	C43H77O8P	NA
PA(42:0)	C45H89O8P	NA
PA(42:2)	C45H85O8P	NA
PA(42:4)	C45H81O8P	NA
PA(42:5)	C45H79O8P	NA
PA(42:10)	C45H69O8P	NA
PA(44:2)	C47H89O8P	NA
PA(44:3)	C47H87O8P	NA
PA(44:4)	C47H85O8P	NA
PA(44:5)	C47H83O8P	NA
PA(44:6)	C47H81O8P	NA
PA(44:8)	C47H77O8P	NA
PA(44:9)	C47H75O8P	NA
PA(44:10)	C47H73O8P	NA
PA(46:0)	C49H97O8P	NA
PA(46:3)	C49H91O8P	NA
PA(46:4)	C49H89O8P	NA
PA(46:5)	C49H87O8P	NA
PA(46:6)	C49H85O8P	NA
PA(46:7)	C49H83O8P	NA
PA(46:8)	C49H81O8P	NA
PA(46:9)	C49H79O8P	NA
PA(46:10)	C49H77O8P	NA
PA(46:11)	C49H75O8P	NA
PA(48:1)	C51H99O8P	NA
PA(48:2)	C51H97O8P	NA
PA(48:3)	C51H95O8P	NA
PA(48:4)	C51H93O8P	NA
PA(48:5)	C51H91O8P	NA
PA(48:6)	C51H89O8P	NA
PA(48:8)	C51H85O8P	NA
PA(48:9)	C51H83O8P	NA
PA(48:10)	C51H81O8P	NA
PA(48:11)	C51H79O8P	NA
PA(48:12)	C51H77O8P	NA
PI(32:0)	C41H79O13P	NA
PI(34:0)	C43H83O13P	NA
PI(34:1)	C43H81O13P	11.5
PI(34:2)	C43H79O13P	10.97
PI(34:3)	C43H77O13P	10.76
PI(36:0)	C45H87O13P	NA
PI(36:1)	C45H85O13P	12.21
PI(36:2)	C45H83O13P	11.64
PI(36:3)	C45H81O13P	11.24
PI(36:4)	C45H79O13P	11.06
PI(38:0)	C47H91O13P	NA
PI(38:1)	C47H89O13P	NA
PI(38:2)	C47H87O13P	12.48
PI(38:3)	C47H85O13P	12.24
PI(38:4)	C47H83O13P	11.8
PI(38:5)	C47H81O13P	11.2
PI(38:6)	C47H79O13P	10.8
PI(40:0)	C49H95O13P	NA
PI(40:1)	C49H93O13P	NA
PI(40:2)	C49H91O13P	NA
PI(40:3)	C49H89O13P	12.83
PI(40:4)	C49H87O13P	12.3
PI(40:6)	C49H83O13P	11.38
PI(40:7)	C49H81O13P	11.16
PI(42:2)	C51H95O13P	NA
PI(42:4)	C51H91O13P	12.88
PI(42:5)	C51H89O13P	12.53
PI(42:6)	C51H87O13P	12.1
PI(42:9)	C51H81O13P	NA
PI(44:2)	C53H99O13P	NA
PI(44:3)	C53H97O13P	NA
PI(46:12)	C55H83O13P	NA
PG(30:0)	C36H71O10P	10.82
PG(32:0)	C38H75O10P	11.62
PG(32:1)	C38H73O10P	10.4
PG(32:2)	C38H71O10P	9.96
PG(34:1)	C40H77O10P	11.73
PG(34:2)	C40H75O10P	10.65
PG(34:3)	C40H73O10P	10.39
PG(36:0)	C42H83O10P	NA
PG(36:2)	C42H79O10P	11.33
PG(36:3)	C42H77O10P	10.94
PG(36:4)	C42H75O10P	10.68
PG(36:6)	C42H71O10P	9.95
PG(38:0)	C44H87O10P	NA
PG(38:1)	C44H85O10P	NA
PG(38:5)	C44H77O10P	10.91
PG(38:6)	C44H75O10P	10.6
PG(38:7)	C44H73O10P	10.2
PG(40:0)	C46H91O10P	NA
PG(40:5)	C46H81O10P	11.46
PG(40:7)	C46H77O10P	10.94
PG(40:8)	C46H75O10P	10.45
PG(42:0)	C48H95O10P	NA
PG(42:5)	C48H85O10P	11.45
PG(42:6)	C48H83O10P	10.95
PG(42:7)	C48H81O10P	11.35
PG(42:8)	C48H79O10P	11.09
PG(42:9)	C48H77O10P	10.75
PG(42:10)	C48H75O10P	10.49
PG(44:0)	C50H99O10P	NA
PG(44:6)	C50H87O10P	11.63
PG(44:7)	C50H85O10P	11.48
PG(44:8)	C50H83O10P	11.01
PG(44:9)	C50H81O10P	11.4
PG(44:11)	C50H77O10P	10.61
PG(44:12)	C50H75O10P	10.43
PG(46:0)	C52H103O10P	NA
PG(46:2)	C52H99O10P	NA
PG(46:3)	C52H97O10P	NA
PG(46:9)	C52H85O10P	11.2
PG(46:11)	C52H81O10P	NA
PG(48:0)	C54H107O10P	NA
PG(48:3)	C54H101O10P	NA
PG(48:4)	C54H99O10P	NA
PG(48:5)	C54H97O10P	NA
PG(48:6)	C54H95O10P	NA
PG(48:10)	C54H87O10P	11.99
PG(48:11)	C54H85O10P	11.39
PG(48:12)	C54H83O10P	NA
CoQ9	C54H82O4	17.74
CoQ10 (Oxidized, Ubiquinone)	C59H90O4	18.24
CoQ10 (Reduced, Ubiquinol)	C59H92O4	18.13
METABOLITES_END
#END