#METABOLOMICS WORKBENCH mmcarter_20250414_130228 DATATRACK_ID:5833 STUDY_ID:ST003874 ANALYSIS_ID:AN006365 PROJECT_ID:PR002428
VERSION             	1
CREATED_ON             	April 21, 2025, 2:09 pm
#PROJECT
PR:PROJECT_TITLE                 	A human milk oligosaccharide alters the microbiome, circulating hormones, and
PR:PROJECT_TITLE                 	metabolites in a randomized controlled trial of older individuals
PR:PROJECT_SUMMARY               	Aging-related immune dysfunction is linked to cancer, atherosclerosis, and
PR:PROJECT_SUMMARY               	neurodegenerative diseases. This 6-week randomized controlled trial evaluated
PR:PROJECT_SUMMARY               	whether 2′-fucosyllactose (2′-FL), a human breast milk oligosaccharide with
PR:PROJECT_SUMMARY               	established benefits in infants and animal models, could improve gut microbiota
PR:PROJECT_SUMMARY               	and immune function in 89 healthy older adults (mean age 67.3 years).. While the
PR:PROJECT_SUMMARY               	primary endpoint of cytokine response change wasn't met, 2′-FL supplementation
PR:PROJECT_SUMMARY               	increased gut Bifidobacterium levels and elevated serum insulin, HDL
PR:PROJECT_SUMMARY               	cholesterol, and FGF21 hormone. Bifidobacterium “responders” experienced
PR:PROJECT_SUMMARY               	additional metabolic and proteomic changes and also performed better on a
PR:PROJECT_SUMMARY               	cognitive test of visual memory. Nonresponders were more likely to lack
PR:PROJECT_SUMMARY               	Bifidobacterium in their gut microbiota at the start of the intervention.
PR:PROJECT_SUMMARY               	Multi-omics analysis indicated a systemic response to 2′-FL, which could be
PR:PROJECT_SUMMARY               	detected in blood and urine, showcasing the potential of this prebiotic to
PR:PROJECT_SUMMARY               	provide diverse benefits for healthy aging. Trial registered at
PR:PROJECT_SUMMARY               	ClinicalTrials.gov (NCT03690999).
PR:INSTITUTE                     	Stanford University
PR:LAST_NAME                     	Carter
PR:FIRST_NAME                    	Matthew
PR:ADDRESS                       	1815 42ND AVE, SAN FRANCISCO, CA, 94122-4007, USA
PR:EMAIL                         	mmcarter@stanford.edu
PR:PHONE                         	8609300248
PR:FUNDING_SOURCE                	Abbott Nutrition
#STUDY
ST:STUDY_TITLE                   	A human milk oligosaccharide alters the microbiome, circulating hormones, and
ST:STUDY_TITLE                   	metabolites in a randomized controlled trial of older individuals
ST:STUDY_SUMMARY                 	Aging-related immune dysfunction is linked to cancer, atherosclerosis, and
ST:STUDY_SUMMARY                 	neurodegenerative diseases. This 6-week randomized controlled trial evaluated
ST:STUDY_SUMMARY                 	whether 2′-fucosyllactose (2′-FL), a human breast milk oligosaccharide with
ST:STUDY_SUMMARY                 	established benefits in infants and animal models, could improve gut microbiota
ST:STUDY_SUMMARY                 	and immune function in 89 healthy older adults (mean age 67.3 years).. While the
ST:STUDY_SUMMARY                 	primary endpoint of cytokine response change wasn't met, 2′-FL supplementation
ST:STUDY_SUMMARY                 	increased gut Bifidobacterium levels and elevated serum insulin, HDL
ST:STUDY_SUMMARY                 	cholesterol, and FGF21 hormone. Bifidobacterium “responders” experienced
ST:STUDY_SUMMARY                 	additional metabolic and proteomic changes and also performed better on a
ST:STUDY_SUMMARY                 	cognitive test of visual memory. Nonresponders were more likely to lack
ST:STUDY_SUMMARY                 	Bifidobacterium in their gut microbiota at the start of the intervention.
ST:STUDY_SUMMARY                 	Multi-omics analysis indicated a systemic response to 2′-FL, which could be
ST:STUDY_SUMMARY                 	detected in blood and urine, showcasing the potential of this prebiotic to
ST:STUDY_SUMMARY                 	provide diverse benefits for healthy aging. Trial registered at
ST:STUDY_SUMMARY                 	ClinicalTrials.gov (NCT03690999). We found three metabolites that had
ST:STUDY_SUMMARY                 	statistically significant interaction effects in our LME modeling:
ST:STUDY_SUMMARY                 	octanoylcarnitine, glutamate and taurine (P = 0.0011, P = 0.042, P = 0.049,
ST:STUDY_SUMMARY                 	respectively, LME, Benjamini-Hochberg corrected, Table S5). Octanoylcarnitine is
ST:STUDY_SUMMARY                 	a medium-chain fatty acid covalently linked to carnitine which undergoes fatty
ST:STUDY_SUMMARY                 	acid oxidation in the mitochondria. Post hoc analysis revealed that
ST:STUDY_SUMMARY                 	octanoylcarnitine decreased significantly in the High Dose 2′-FL group during
ST:STUDY_SUMMARY                 	the intervention (P = 0.015, Wilcoxon rank-sum test, Figure 4A), but not in the
ST:STUDY_SUMMARY                 	Low Dose 2′-FL group or Placebo group (P = 0.27, P = 0.39, respectively,
ST:STUDY_SUMMARY                 	Wilcoxon rank-sum test). Glutamate and taurine significantly increased in
ST:STUDY_SUMMARY                 	abundance in the Placebo group during the intervention (P = 0.028 for glutamate,
ST:STUDY_SUMMARY                 	P = 0.003 for taurine, Wilcoxon rank-sum tests). Levels of these metabolites
ST:STUDY_SUMMARY                 	also increased in the Low Dose 2′-FL (P = 0.14 for glutamate, P = 0.10 for
ST:STUDY_SUMMARY                 	taurine, Wilcoxon rank-sum tests) and High Dose 2′-FL groups (P = 0.12 for
ST:STUDY_SUMMARY                 	glutamate, P = 0.13 for taurine, Wilcoxon rank-sum tests), albeit not in a
ST:STUDY_SUMMARY                 	statistically significant manner.
ST:INSTITUTE                     	Stanford University
ST:DEPARTMENT                    	Microbiology and Immunology
ST:LABORATORY                    	Sonnenburg
ST:LAST_NAME                     	Carter
ST:FIRST_NAME                    	Matt
ST:ADDRESS                       	1815 42ND AVE
ST:EMAIL                         	mmcarter@stanford.edu
ST:PHONE                         	18609300248
ST:NUM_GROUPS                    	3
ST:TOTAL_SUBJECTS                	89
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:AGE_OR_AGE_RANGE              	67.3
SU:GENDER                        	Male and female
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_001	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_001.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_002	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_002.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_003	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_003.mzML
SUBJECT_SAMPLE_FACTORS           	4080	210729_RAMP_serum_c18pos_004	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=69.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_004.mzML
SUBJECT_SAMPLE_FACTORS           	4017	210729_RAMP_serum_c18pos_005	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_005.mzML
SUBJECT_SAMPLE_FACTORS           	4078	210729_RAMP_serum_c18pos_006	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_006.mzML
SUBJECT_SAMPLE_FACTORS           	4018	210729_RAMP_serum_c18pos_007	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_007.mzML
SUBJECT_SAMPLE_FACTORS           	4055	210729_RAMP_serum_c18pos_008	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_008.mzML
SUBJECT_SAMPLE_FACTORS           	4090	210729_RAMP_serum_c18pos_009	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_009.mzML
SUBJECT_SAMPLE_FACTORS           	4083	210729_RAMP_serum_c18pos_010	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_010.mzML
SUBJECT_SAMPLE_FACTORS           	4052	210729_RAMP_serum_c18pos_011	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_011.mzML
SUBJECT_SAMPLE_FACTORS           	4083	210729_RAMP_serum_c18pos_012	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_012.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_013	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_013.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_014	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_014.mzML
SUBJECT_SAMPLE_FACTORS           	4083	210729_RAMP_serum_c18pos_015	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_015.mzML
SUBJECT_SAMPLE_FACTORS           	4078	210729_RAMP_serum_c18pos_016	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_016.mzML
SUBJECT_SAMPLE_FACTORS           	4061	210729_RAMP_serum_c18pos_017	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_017.mzML
SUBJECT_SAMPLE_FACTORS           	4035	210729_RAMP_serum_c18pos_018	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_018.mzML
SUBJECT_SAMPLE_FACTORS           	4071	210729_RAMP_serum_c18pos_019	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_019.mzML
SUBJECT_SAMPLE_FACTORS           	4067	210729_RAMP_serum_c18pos_020	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_020.mzML
SUBJECT_SAMPLE_FACTORS           	4003	210729_RAMP_serum_c18pos_021	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_021.mzML
SUBJECT_SAMPLE_FACTORS           	4070	210729_RAMP_serum_c18pos_022	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_022.mzML
SUBJECT_SAMPLE_FACTORS           	4015	210729_RAMP_serum_c18pos_023	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=66.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_023.mzML
SUBJECT_SAMPLE_FACTORS           	4087	210729_RAMP_serum_c18pos_024	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=64.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_024.mzML
SUBJECT_SAMPLE_FACTORS           	4039	210729_RAMP_serum_c18pos_025	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=79.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_025.mzML
SUBJECT_SAMPLE_FACTORS           	4080	210729_RAMP_serum_c18pos_026	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=69.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_026.mzML
SUBJECT_SAMPLE_FACTORS           	4077	210729_RAMP_serum_c18pos_027	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_027.mzML
SUBJECT_SAMPLE_FACTORS           	4077	210729_RAMP_serum_c18pos_028	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_028.mzML
SUBJECT_SAMPLE_FACTORS           	4076	210729_RAMP_serum_c18pos_029	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=62.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_029.mzML
SUBJECT_SAMPLE_FACTORS           	4081	210729_RAMP_serum_c18pos_030	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=78; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_030.mzML
SUBJECT_SAMPLE_FACTORS           	4071	210729_RAMP_serum_c18pos_031	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_031.mzML
SUBJECT_SAMPLE_FACTORS           	4021	210729_RAMP_serum_c18pos_032	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=83.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_032.mzML
SUBJECT_SAMPLE_FACTORS           	4081	210729_RAMP_serum_c18pos_033	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=78; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_033.mzML
SUBJECT_SAMPLE_FACTORS           	4019	210729_RAMP_serum_c18pos_034	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_034.mzML
SUBJECT_SAMPLE_FACTORS           	4071	210729_RAMP_serum_c18pos_035	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_035.mzML
SUBJECT_SAMPLE_FACTORS           	4021	210729_RAMP_serum_c18pos_036	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=83.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_036.mzML
SUBJECT_SAMPLE_FACTORS           	4003	210729_RAMP_serum_c18pos_037	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_037.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_038	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_038.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_039	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_039.mzML
SUBJECT_SAMPLE_FACTORS           	4071	210729_RAMP_serum_c18pos_040	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_040.mzML
SUBJECT_SAMPLE_FACTORS           	4081	210729_RAMP_serum_c18pos_041	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=78; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_041.mzML
SUBJECT_SAMPLE_FACTORS           	4055	210729_RAMP_serum_c18pos_042	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_042.mzML
SUBJECT_SAMPLE_FACTORS           	4070	210729_RAMP_serum_c18pos_043	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_043.mzML
SUBJECT_SAMPLE_FACTORS           	4019	210729_RAMP_serum_c18pos_044	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_044.mzML
SUBJECT_SAMPLE_FACTORS           	4081	210729_RAMP_serum_c18pos_045	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=78; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_045.mzML
SUBJECT_SAMPLE_FACTORS           	4039	210729_RAMP_serum_c18pos_046	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=79.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_046.mzML
SUBJECT_SAMPLE_FACTORS           	4035	210729_RAMP_serum_c18pos_047	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_047.mzML
SUBJECT_SAMPLE_FACTORS           	4078	210729_RAMP_serum_c18pos_048	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_048.mzML
SUBJECT_SAMPLE_FACTORS           	4017	210729_RAMP_serum_c18pos_049	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_049.mzML
SUBJECT_SAMPLE_FACTORS           	4061	210729_RAMP_serum_c18pos_050	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_050.mzML
SUBJECT_SAMPLE_FACTORS           	4076	210729_RAMP_serum_c18pos_051	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=62.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_051.mzML
SUBJECT_SAMPLE_FACTORS           	4055	210729_RAMP_serum_c18pos_052	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_052.mzML
SUBJECT_SAMPLE_FACTORS           	4021	210729_RAMP_serum_c18pos_053	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=83.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_053.mzML
SUBJECT_SAMPLE_FACTORS           	4078	210729_RAMP_serum_c18pos_054	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_054.mzML
SUBJECT_SAMPLE_FACTORS           	4019	210729_RAMP_serum_c18pos_055	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_055.mzML
SUBJECT_SAMPLE_FACTORS           	4015	210729_RAMP_serum_c18pos_056	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=66.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_056.mzML
SUBJECT_SAMPLE_FACTORS           	4017	210729_RAMP_serum_c18pos_057	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_057.mzML
SUBJECT_SAMPLE_FACTORS           	4070	210729_RAMP_serum_c18pos_058	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_058.mzML
SUBJECT_SAMPLE_FACTORS           	4070	210729_RAMP_serum_c18pos_059	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_059.mzML
SUBJECT_SAMPLE_FACTORS           	4090	210729_RAMP_serum_c18pos_060	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_060.mzML
SUBJECT_SAMPLE_FACTORS           	4018	210729_RAMP_serum_c18pos_061	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_061.mzML
SUBJECT_SAMPLE_FACTORS           	4087	210729_RAMP_serum_c18pos_062	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=64.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_062.mzML
SUBJECT_SAMPLE_FACTORS           	4018	210729_RAMP_serum_c18pos_063	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_063.mzML
SUBJECT_SAMPLE_FACTORS           	4080	210729_RAMP_serum_c18pos_064	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=69.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_064.mzML
SUBJECT_SAMPLE_FACTORS           	4080	210729_RAMP_serum_c18pos_065	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=69.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_065.mzML
SUBJECT_SAMPLE_FACTORS           	4061	210729_RAMP_serum_c18pos_066	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_066.mzML
SUBJECT_SAMPLE_FACTORS           	4018	210729_RAMP_serum_c18pos_067	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_067.mzML
SUBJECT_SAMPLE_FACTORS           	4067	210729_RAMP_serum_c18pos_068	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_068.mzML
SUBJECT_SAMPLE_FACTORS           	4052	210729_RAMP_serum_c18pos_069	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_069.mzML
SUBJECT_SAMPLE_FACTORS           	4015	210729_RAMP_serum_c18pos_070	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=66.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_070.mzML
SUBJECT_SAMPLE_FACTORS           	4061	210729_RAMP_serum_c18pos_071	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_071.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_072	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_072.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_073	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_073.mzML
SUBJECT_SAMPLE_FACTORS           	4052	210729_RAMP_serum_c18pos_074	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_074.mzML
SUBJECT_SAMPLE_FACTORS           	4067	210729_RAMP_serum_c18pos_075	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_075.mzML
SUBJECT_SAMPLE_FACTORS           	4067	210729_RAMP_serum_c18pos_076	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_076.mzML
SUBJECT_SAMPLE_FACTORS           	4003	210729_RAMP_serum_c18pos_077	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_077.mzML
SUBJECT_SAMPLE_FACTORS           	4039	210729_RAMP_serum_c18pos_078	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=79.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_078.mzML
SUBJECT_SAMPLE_FACTORS           	4055	210729_RAMP_serum_c18pos_079	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_079.mzML
SUBJECT_SAMPLE_FACTORS           	4090	210729_RAMP_serum_c18pos_080	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_080.mzML
SUBJECT_SAMPLE_FACTORS           	4090	210729_RAMP_serum_c18pos_081	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_081.mzML
SUBJECT_SAMPLE_FACTORS           	4076	210729_RAMP_serum_c18pos_082	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=62.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_082.mzML
SUBJECT_SAMPLE_FACTORS           	4087	210729_RAMP_serum_c18pos_083	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=64.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_083.mzML
SUBJECT_SAMPLE_FACTORS           	4083	210729_RAMP_serum_c18pos_084	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_084.mzML
SUBJECT_SAMPLE_FACTORS           	4035	210729_RAMP_serum_c18pos_085	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_085.mzML
SUBJECT_SAMPLE_FACTORS           	4087	210729_RAMP_serum_c18pos_086	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=64.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_086.mzML
SUBJECT_SAMPLE_FACTORS           	4021	210729_RAMP_serum_c18pos_087	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=83.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_087.mzML
SUBJECT_SAMPLE_FACTORS           	4052	210729_RAMP_serum_c18pos_088	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_088.mzML
SUBJECT_SAMPLE_FACTORS           	4019	210729_RAMP_serum_c18pos_089	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_089.mzML
SUBJECT_SAMPLE_FACTORS           	4017	210729_RAMP_serum_c18pos_090	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_090.mzML
SUBJECT_SAMPLE_FACTORS           	4077	210729_RAMP_serum_c18pos_091	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_091.mzML
SUBJECT_SAMPLE_FACTORS           	4003	210729_RAMP_serum_c18pos_092	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_092.mzML
SUBJECT_SAMPLE_FACTORS           	4015	210729_RAMP_serum_c18pos_093	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=66.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_093.mzML
SUBJECT_SAMPLE_FACTORS           	4076	210729_RAMP_serum_c18pos_094	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=62.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_094.mzML
SUBJECT_SAMPLE_FACTORS           	4077	210729_RAMP_serum_c18pos_095	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_095.mzML
SUBJECT_SAMPLE_FACTORS           	4039	210729_RAMP_serum_c18pos_096	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=79.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_096.mzML
SUBJECT_SAMPLE_FACTORS           	4035	210729_RAMP_serum_c18pos_097	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_097.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_098	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_098.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_099	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_099.mzML
SUBJECT_SAMPLE_FACTORS           	4046	210729_RAMP_serum_c18pos_100	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_100.mzML
SUBJECT_SAMPLE_FACTORS           	4088	210729_RAMP_serum_c18pos_101	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_101.mzML
SUBJECT_SAMPLE_FACTORS           	4072	210729_RAMP_serum_c18pos_102	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.8; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_102.mzML
SUBJECT_SAMPLE_FACTORS           	4097	210729_RAMP_serum_c18pos_103	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_103.mzML
SUBJECT_SAMPLE_FACTORS           	4093	210729_RAMP_serum_c18pos_104	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_104.mzML
SUBJECT_SAMPLE_FACTORS           	4069	210729_RAMP_serum_c18pos_105	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=64.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_105.mzML
SUBJECT_SAMPLE_FACTORS           	4062	210729_RAMP_serum_c18pos_106	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.6; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_106.mzML
SUBJECT_SAMPLE_FACTORS           	4016	210729_RAMP_serum_c18pos_107	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_107.mzML
SUBJECT_SAMPLE_FACTORS           	4022	210729_RAMP_serum_c18pos_108	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_108.mzML
SUBJECT_SAMPLE_FACTORS           	4046	210729_RAMP_serum_c18pos_109	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_109.mzML
SUBJECT_SAMPLE_FACTORS           	4007	210729_RAMP_serum_c18pos_110	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_110.mzML
SUBJECT_SAMPLE_FACTORS           	4020	210729_RAMP_serum_c18pos_111	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_111.mzML
SUBJECT_SAMPLE_FACTORS           	4062	210729_RAMP_serum_c18pos_112	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.6; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_112.mzML
SUBJECT_SAMPLE_FACTORS           	4064	210729_RAMP_serum_c18pos_113	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_113.mzML
SUBJECT_SAMPLE_FACTORS           	4069	210729_RAMP_serum_c18pos_114	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=64.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_114.mzML
SUBJECT_SAMPLE_FACTORS           	4069	210729_RAMP_serum_c18pos_115	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=64.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_115.mzML
SUBJECT_SAMPLE_FACTORS           	4007	210729_RAMP_serum_c18pos_116	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_116.mzML
SUBJECT_SAMPLE_FACTORS           	4038	210729_RAMP_serum_c18pos_117	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_117.mzML
SUBJECT_SAMPLE_FACTORS           	4002	210729_RAMP_serum_c18pos_118	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=78.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_118.mzML
SUBJECT_SAMPLE_FACTORS           	4020	210729_RAMP_serum_c18pos_119	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_119.mzML
SUBJECT_SAMPLE_FACTORS           	4058	210729_RAMP_serum_c18pos_120	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_120.mzML
SUBJECT_SAMPLE_FACTORS           	4084	210729_RAMP_serum_c18pos_121	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_121.mzML
SUBJECT_SAMPLE_FACTORS           	4069	210729_RAMP_serum_c18pos_122	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=64.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_122.mzML
SUBJECT_SAMPLE_FACTORS           	4089	210729_RAMP_serum_c18pos_123	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_123.mzML
SUBJECT_SAMPLE_FACTORS           	4000	210729_RAMP_serum_c18pos_124	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_124.mzML
SUBJECT_SAMPLE_FACTORS           	4038	210729_RAMP_serum_c18pos_125	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_125.mzML
SUBJECT_SAMPLE_FACTORS           	4058	210729_RAMP_serum_c18pos_126	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_126.mzML
SUBJECT_SAMPLE_FACTORS           	4088	210729_RAMP_serum_c18pos_127	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_127.mzML
SUBJECT_SAMPLE_FACTORS           	4065	210729_RAMP_serum_c18pos_128	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_128.mzML
SUBJECT_SAMPLE_FACTORS           	4064	210729_RAMP_serum_c18pos_129	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_129.mzML
SUBJECT_SAMPLE_FACTORS           	4058	210729_RAMP_serum_c18pos_130	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_130.mzML
SUBJECT_SAMPLE_FACTORS           	4012	210729_RAMP_serum_c18pos_131	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_131.mzML
SUBJECT_SAMPLE_FACTORS           	4072	210729_RAMP_serum_c18pos_132	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.8; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_132.mzML
SUBJECT_SAMPLE_FACTORS           	4062	210729_RAMP_serum_c18pos_133	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.6; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_133.mzML
SUBJECT_SAMPLE_FACTORS           	4002	210729_RAMP_serum_c18pos_134	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=78.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_134.mzML
SUBJECT_SAMPLE_FACTORS           	4022	210729_RAMP_serum_c18pos_135	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_135.mzML
SUBJECT_SAMPLE_FACTORS           	4040	210729_RAMP_serum_c18pos_136	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=67.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_136.mzML
SUBJECT_SAMPLE_FACTORS           	4093	210729_RAMP_serum_c18pos_137	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_137.mzML
SUBJECT_SAMPLE_FACTORS           	4012	210729_RAMP_serum_c18pos_138	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_138.mzML
SUBJECT_SAMPLE_FACTORS           	4000	210729_RAMP_serum_c18pos_139	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_139.mzML
SUBJECT_SAMPLE_FACTORS           	4062	210729_RAMP_serum_c18pos_140	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.6; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_140.mzML
SUBJECT_SAMPLE_FACTORS           	4000	210729_RAMP_serum_c18pos_141	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_141.mzML
SUBJECT_SAMPLE_FACTORS           	4097	210729_RAMP_serum_c18pos_142	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_142.mzML
SUBJECT_SAMPLE_FACTORS           	4089	210729_RAMP_serum_c18pos_143	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_143.mzML
SUBJECT_SAMPLE_FACTORS           	4065	210729_RAMP_serum_c18pos_144	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_144.mzML
SUBJECT_SAMPLE_FACTORS           	4089	210729_RAMP_serum_c18pos_145	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_145.mzML
SUBJECT_SAMPLE_FACTORS           	4064	210729_RAMP_serum_c18pos_146	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_146.mzML
SUBJECT_SAMPLE_FACTORS           	4097	210729_RAMP_serum_c18pos_147	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_147.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_148	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_148.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_149	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_149.mzML
SUBJECT_SAMPLE_FACTORS           	4038	210729_RAMP_serum_c18pos_150	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_150.mzML
SUBJECT_SAMPLE_FACTORS           	4038	210729_RAMP_serum_c18pos_151	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=63.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_151.mzML
SUBJECT_SAMPLE_FACTORS           	4022	210729_RAMP_serum_c18pos_152	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_152.mzML
SUBJECT_SAMPLE_FACTORS           	4002	210729_RAMP_serum_c18pos_153	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=78.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_153.mzML
SUBJECT_SAMPLE_FACTORS           	4072	210729_RAMP_serum_c18pos_154	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.8; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_154.mzML
SUBJECT_SAMPLE_FACTORS           	4002	210729_RAMP_serum_c18pos_155	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=78.3; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_155.mzML
SUBJECT_SAMPLE_FACTORS           	4065	210729_RAMP_serum_c18pos_156	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_156.mzML
SUBJECT_SAMPLE_FACTORS           	4046	210729_RAMP_serum_c18pos_157	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_157.mzML
SUBJECT_SAMPLE_FACTORS           	4084	210729_RAMP_serum_c18pos_158	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_158.mzML
SUBJECT_SAMPLE_FACTORS           	4012	210729_RAMP_serum_c18pos_159	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_159.mzML
SUBJECT_SAMPLE_FACTORS           	4020	210729_RAMP_serum_c18pos_160	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_160.mzML
SUBJECT_SAMPLE_FACTORS           	4007	210729_RAMP_serum_c18pos_161	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_161.mzML
SUBJECT_SAMPLE_FACTORS           	4092	210729_RAMP_serum_c18pos_162	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_162.mzML
SUBJECT_SAMPLE_FACTORS           	4000	210729_RAMP_serum_c18pos_163	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_163.mzML
SUBJECT_SAMPLE_FACTORS           	4088	210729_RAMP_serum_c18pos_164	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_164.mzML
SUBJECT_SAMPLE_FACTORS           	4040	210729_RAMP_serum_c18pos_165	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=67.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_165.mzML
SUBJECT_SAMPLE_FACTORS           	4040	210729_RAMP_serum_c18pos_166	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=67.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_166.mzML
SUBJECT_SAMPLE_FACTORS           	4020	210729_RAMP_serum_c18pos_167	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=67.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_167.mzML
SUBJECT_SAMPLE_FACTORS           	4058	210729_RAMP_serum_c18pos_168	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_168.mzML
SUBJECT_SAMPLE_FACTORS           	4097	210729_RAMP_serum_c18pos_169	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_169.mzML
SUBJECT_SAMPLE_FACTORS           	4092	210729_RAMP_serum_c18pos_170	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_170.mzML
SUBJECT_SAMPLE_FACTORS           	4084	210729_RAMP_serum_c18pos_171	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_171.mzML
SUBJECT_SAMPLE_FACTORS           	4092	210729_RAMP_serum_c18pos_172	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_172.mzML
SUBJECT_SAMPLE_FACTORS           	4093	210729_RAMP_serum_c18pos_173	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_173.mzML
SUBJECT_SAMPLE_FACTORS           	4016	210729_RAMP_serum_c18pos_174	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_174.mzML
SUBJECT_SAMPLE_FACTORS           	4072	210729_RAMP_serum_c18pos_175	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.8; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_175.mzML
SUBJECT_SAMPLE_FACTORS           	4092	210729_RAMP_serum_c18pos_176	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_176.mzML
SUBJECT_SAMPLE_FACTORS           	4022	210729_RAMP_serum_c18pos_177	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_177.mzML
SUBJECT_SAMPLE_FACTORS           	4046	210729_RAMP_serum_c18pos_178	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=70.1; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_178.mzML
SUBJECT_SAMPLE_FACTORS           	4084	210729_RAMP_serum_c18pos_179	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_179.mzML
SUBJECT_SAMPLE_FACTORS           	4040	210729_RAMP_serum_c18pos_180	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=67.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_180.mzML
SUBJECT_SAMPLE_FACTORS           	4016	210729_RAMP_serum_c18pos_181	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_181.mzML
SUBJECT_SAMPLE_FACTORS           	4088	210729_RAMP_serum_c18pos_182	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=70.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_182.mzML
SUBJECT_SAMPLE_FACTORS           	4093	210729_RAMP_serum_c18pos_183	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_183.mzML
SUBJECT_SAMPLE_FACTORS           	4012	210729_RAMP_serum_c18pos_184	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_184.mzML
SUBJECT_SAMPLE_FACTORS           	4065	210729_RAMP_serum_c18pos_185	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_185.mzML
SUBJECT_SAMPLE_FACTORS           	4007	210729_RAMP_serum_c18pos_186	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=65; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_186.mzML
SUBJECT_SAMPLE_FACTORS           	4064	210729_RAMP_serum_c18pos_187	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_187.mzML
SUBJECT_SAMPLE_FACTORS           	4089	210729_RAMP_serum_c18pos_188	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_188.mzML
SUBJECT_SAMPLE_FACTORS           	4016	210729_RAMP_serum_c18pos_189	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=60; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_189.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_190	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_190.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_191	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_191.mzML
SUBJECT_SAMPLE_FACTORS           	4096	210729_RAMP_serum_c18pos_192	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_192.mzML
SUBJECT_SAMPLE_FACTORS           	4004	210729_RAMP_serum_c18pos_193	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=60.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_193.mzML
SUBJECT_SAMPLE_FACTORS           	4049	210729_RAMP_serum_c18pos_194	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_194.mzML
SUBJECT_SAMPLE_FACTORS           	4034	210729_RAMP_serum_c18pos_195	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_195.mzML
SUBJECT_SAMPLE_FACTORS           	4051	210729_RAMP_serum_c18pos_196	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_196.mzML
SUBJECT_SAMPLE_FACTORS           	4054	210729_RAMP_serum_c18pos_197	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_197.mzML
SUBJECT_SAMPLE_FACTORS           	4009	210729_RAMP_serum_c18pos_198	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.6; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_198.mzML
SUBJECT_SAMPLE_FACTORS           	4006	210729_RAMP_serum_c18pos_199	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=71.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_199.mzML
SUBJECT_SAMPLE_FACTORS           	4060	210729_RAMP_serum_c18pos_200	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=74.5; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_200.mzML
SUBJECT_SAMPLE_FACTORS           	4049	210729_RAMP_serum_c18pos_201	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_201.mzML
SUBJECT_SAMPLE_FACTORS           	4075	210729_RAMP_serum_c18pos_202	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_202.mzML
SUBJECT_SAMPLE_FACTORS           	4027	210729_RAMP_serum_c18pos_203	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=71.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_203.mzML
SUBJECT_SAMPLE_FACTORS           	4075	210729_RAMP_serum_c18pos_204	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_204.mzML
SUBJECT_SAMPLE_FACTORS           	4073	210729_RAMP_serum_c18pos_205	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_205.mzML
SUBJECT_SAMPLE_FACTORS           	4073	210729_RAMP_serum_c18pos_206	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_206.mzML
SUBJECT_SAMPLE_FACTORS           	4030	210729_RAMP_serum_c18pos_207	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.7; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_207.mzML
SUBJECT_SAMPLE_FACTORS           	4060	210729_RAMP_serum_c18pos_208	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=74.5; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_208.mzML
SUBJECT_SAMPLE_FACTORS           	4013	210729_RAMP_serum_c18pos_209	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_209.mzML
SUBJECT_SAMPLE_FACTORS           	4086	210729_RAMP_serum_c18pos_210	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=68.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_210.mzML
SUBJECT_SAMPLE_FACTORS           	4025	210729_RAMP_serum_c18pos_211	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_211.mzML
SUBJECT_SAMPLE_FACTORS           	4033	210729_RAMP_serum_c18pos_212	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73.3; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_212.mzML
SUBJECT_SAMPLE_FACTORS           	4034	210729_RAMP_serum_c18pos_213	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_213.mzML
SUBJECT_SAMPLE_FACTORS           	4013	210729_RAMP_serum_c18pos_214	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_214.mzML
SUBJECT_SAMPLE_FACTORS           	4006	210729_RAMP_serum_c18pos_215	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=71.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_215.mzML
SUBJECT_SAMPLE_FACTORS           	4027	210729_RAMP_serum_c18pos_216	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=71.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_216.mzML
SUBJECT_SAMPLE_FACTORS           	4029	210729_RAMP_serum_c18pos_217	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=71.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_217.mzML
SUBJECT_SAMPLE_FACTORS           	4033	210729_RAMP_serum_c18pos_218	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73.3; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_218.mzML
SUBJECT_SAMPLE_FACTORS           	4010	210729_RAMP_serum_c18pos_219	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_219.mzML
SUBJECT_SAMPLE_FACTORS           	4096	210729_RAMP_serum_c18pos_220	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_220.mzML
SUBJECT_SAMPLE_FACTORS           	4033	210729_RAMP_serum_c18pos_221	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73.3; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_221.mzML
SUBJECT_SAMPLE_FACTORS           	4034	210729_RAMP_serum_c18pos_222	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_222.mzML
SUBJECT_SAMPLE_FACTORS           	4045	210729_RAMP_serum_c18pos_223	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=75.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_223.mzML
SUBJECT_SAMPLE_FACTORS           	4033	210729_RAMP_serum_c18pos_224	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73.3; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_224.mzML
SUBJECT_SAMPLE_FACTORS           	4049	210729_RAMP_serum_c18pos_225	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_225.mzML
SUBJECT_SAMPLE_FACTORS           	4054	210729_RAMP_serum_c18pos_226	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_226.mzML
SUBJECT_SAMPLE_FACTORS           	4086	210729_RAMP_serum_c18pos_227	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=68.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_227.mzML
SUBJECT_SAMPLE_FACTORS           	4045	210729_RAMP_serum_c18pos_228	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=75.7; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_228.mzML
SUBJECT_SAMPLE_FACTORS           	4027	210729_RAMP_serum_c18pos_229	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=71.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_229.mzML
SUBJECT_SAMPLE_FACTORS           	4051	210729_RAMP_serum_c18pos_230	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_230.mzML
SUBJECT_SAMPLE_FACTORS           	4010	210729_RAMP_serum_c18pos_231	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_231.mzML
SUBJECT_SAMPLE_FACTORS           	4051	210729_RAMP_serum_c18pos_232	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_232.mzML
SUBJECT_SAMPLE_FACTORS           	4047	210729_RAMP_serum_c18pos_233	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_233.mzML
SUBJECT_SAMPLE_FACTORS           	4006	210729_RAMP_serum_c18pos_234	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=71.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_234.mzML
SUBJECT_SAMPLE_FACTORS           	4060	210729_RAMP_serum_c18pos_235	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=74.5; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_235.mzML
SUBJECT_SAMPLE_FACTORS           	4009	210729_RAMP_serum_c18pos_236	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.6; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_236.mzML
SUBJECT_SAMPLE_FACTORS           	4030	210729_RAMP_serum_c18pos_237	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.7; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_237.mzML
SUBJECT_SAMPLE_FACTORS           	4027	210729_RAMP_serum_c18pos_238	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=71.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_238.mzML
SUBJECT_SAMPLE_FACTORS           	4029	210729_RAMP_serum_c18pos_239	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=71.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_239.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_240	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_240.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_241	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_241.mzML
SUBJECT_SAMPLE_FACTORS           	4004	210729_RAMP_serum_c18pos_242	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=60.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_242.mzML
SUBJECT_SAMPLE_FACTORS           	4075	210729_RAMP_serum_c18pos_243	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_243.mzML
SUBJECT_SAMPLE_FACTORS           	4047	210729_RAMP_serum_c18pos_244	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_244.mzML
SUBJECT_SAMPLE_FACTORS           	4054	210729_RAMP_serum_c18pos_245	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_245.mzML
SUBJECT_SAMPLE_FACTORS           	4086	210729_RAMP_serum_c18pos_246	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=68.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_246.mzML
SUBJECT_SAMPLE_FACTORS           	4096	210729_RAMP_serum_c18pos_247	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64.6; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_247.mzML
SUBJECT_SAMPLE_FACTORS           	4025	210729_RAMP_serum_c18pos_248	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_248.mzML
SUBJECT_SAMPLE_FACTORS           	4030	210729_RAMP_serum_c18pos_249	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.7; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_249.mzML
SUBJECT_SAMPLE_FACTORS           	4073	210729_RAMP_serum_c18pos_250	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_250.mzML
SUBJECT_SAMPLE_FACTORS           	4013	210729_RAMP_serum_c18pos_251	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_251.mzML
SUBJECT_SAMPLE_FACTORS           	4029	210729_RAMP_serum_c18pos_252	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=71.9; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_252.mzML
SUBJECT_SAMPLE_FACTORS           	4004	210729_RAMP_serum_c18pos_253	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=60.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_253.mzML
SUBJECT_SAMPLE_FACTORS           	4073	210729_RAMP_serum_c18pos_254	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.4; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_254.mzML
SUBJECT_SAMPLE_FACTORS           	4006	210729_RAMP_serum_c18pos_255	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=71.5; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_255.mzML
SUBJECT_SAMPLE_FACTORS           	4051	210729_RAMP_serum_c18pos_256	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=73; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_256.mzML
SUBJECT_SAMPLE_FACTORS           	4066	210729_RAMP_serum_c18pos_257	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=62.2; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_257.mzML
SUBJECT_SAMPLE_FACTORS           	4025	210729_RAMP_serum_c18pos_258	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_258.mzML
SUBJECT_SAMPLE_FACTORS           	4047	210729_RAMP_serum_c18pos_259	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_259.mzML
SUBJECT_SAMPLE_FACTORS           	4054	210729_RAMP_serum_c18pos_260	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_260.mzML
SUBJECT_SAMPLE_FACTORS           	4047	210729_RAMP_serum_c18pos_261	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_261.mzML
SUBJECT_SAMPLE_FACTORS           	4025	210729_RAMP_serum_c18pos_262	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.8; Gender=Female; Batch_Num=1; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_262.mzML
SUBJECT_SAMPLE_FACTORS           	4047	210729_RAMP_serum_c18pos_run2_004	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_004.mzML
SUBJECT_SAMPLE_FACTORS           	4025	210729_RAMP_serum_c18pos_run2_005	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=67.8; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_005.mzML
SUBJECT_SAMPLE_FACTORS           	4086	210729_RAMP_serum_c18pos_run2_006	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=68.1; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_006.mzML
SUBJECT_SAMPLE_FACTORS           	4010	210729_RAMP_serum_c18pos_run2_007	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.6; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_007.mzML
SUBJECT_SAMPLE_FACTORS           	4075	210729_RAMP_serum_c18pos_run2_008	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_008.mzML
SUBJECT_SAMPLE_FACTORS           	4009	210729_RAMP_serum_c18pos_run2_009	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.6; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_009.mzML
SUBJECT_SAMPLE_FACTORS           	4004	210729_RAMP_serum_c18pos_run2_010	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=60.2; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_010.mzML
SUBJECT_SAMPLE_FACTORS           	4013	210729_RAMP_serum_c18pos_run2_011	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_011.mzML
SUBJECT_SAMPLE_FACTORS           	4096	210729_RAMP_serum_c18pos_run2_012	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64.6; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_012.mzML
SUBJECT_SAMPLE_FACTORS           	4066	210729_RAMP_serum_c18pos_run2_013	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=62.2; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_013.mzML
SUBJECT_SAMPLE_FACTORS           	4034	210729_RAMP_serum_c18pos_run2_014	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_014.mzML
SUBJECT_SAMPLE_FACTORS           	4009	210729_RAMP_serum_c18pos_run2_015	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.6; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_015.mzML
SUBJECT_SAMPLE_FACTORS           	4045	210729_RAMP_serum_c18pos_run2_016	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=75.7; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_016.mzML
SUBJECT_SAMPLE_FACTORS           	4030	210729_RAMP_serum_c18pos_run2_017	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=72.7; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_017.mzML
SUBJECT_SAMPLE_FACTORS           	4045	210729_RAMP_serum_c18pos_run2_018	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=75.7; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_018.mzML
SUBJECT_SAMPLE_FACTORS           	4066	210729_RAMP_serum_c18pos_run2_019	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=62.2; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_019.mzML
SUBJECT_SAMPLE_FACTORS           	4029	210729_RAMP_serum_c18pos_run2_020	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=71.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_020.mzML
SUBJECT_SAMPLE_FACTORS           	4066	210729_RAMP_serum_c18pos_run2_021	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=62.2; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_021.mzML
SUBJECT_SAMPLE_FACTORS           	4049	210729_RAMP_serum_c18pos_run2_022	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61.7; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_022.mzML
SUBJECT_SAMPLE_FACTORS           	4010	210729_RAMP_serum_c18pos_run2_023	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=66.6; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_023.mzML
SUBJECT_SAMPLE_FACTORS           	4060	210729_RAMP_serum_c18pos_run2_024	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=74.5; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_024.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_025	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_025.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_026	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_026.mzML
SUBJECT_SAMPLE_FACTORS           	4057	210729_RAMP_serum_c18pos_run2_027	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_027.mzML
SUBJECT_SAMPLE_FACTORS           	4036	210729_RAMP_serum_c18pos_run2_028	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_028.mzML
SUBJECT_SAMPLE_FACTORS           	4063	210729_RAMP_serum_c18pos_run2_029	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_029.mzML
SUBJECT_SAMPLE_FACTORS           	4082	210729_RAMP_serum_c18pos_run2_030	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.6; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_030.mzML
SUBJECT_SAMPLE_FACTORS           	4037	210729_RAMP_serum_c18pos_run2_031	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=75; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_031.mzML
SUBJECT_SAMPLE_FACTORS           	4001	210729_RAMP_serum_c18pos_run2_032	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=72.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_032.mzML
SUBJECT_SAMPLE_FACTORS           	4056	210729_RAMP_serum_c18pos_run2_033	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_033.mzML
SUBJECT_SAMPLE_FACTORS           	4074	210729_RAMP_serum_c18pos_run2_034	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_034.mzML
SUBJECT_SAMPLE_FACTORS           	4036	210729_RAMP_serum_c18pos_run2_035	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_035.mzML
SUBJECT_SAMPLE_FACTORS           	4023	210729_RAMP_serum_c18pos_run2_036	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_036.mzML
SUBJECT_SAMPLE_FACTORS           	4068	210729_RAMP_serum_c18pos_run2_037	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_037.mzML
SUBJECT_SAMPLE_FACTORS           	4068	210729_RAMP_serum_c18pos_run2_038	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_038.mzML
SUBJECT_SAMPLE_FACTORS           	4008	210729_RAMP_serum_c18pos_run2_039	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=83.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_039.mzML
SUBJECT_SAMPLE_FACTORS           	4074	210729_RAMP_serum_c18pos_run2_040	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_040.mzML
SUBJECT_SAMPLE_FACTORS           	4074	210729_RAMP_serum_c18pos_run2_041	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_041.mzML
SUBJECT_SAMPLE_FACTORS           	4048	210729_RAMP_serum_c18pos_run2_042	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=62.6; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_042.mzML
SUBJECT_SAMPLE_FACTORS           	4037	210729_RAMP_serum_c18pos_run2_043	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=75; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_043.mzML
SUBJECT_SAMPLE_FACTORS           	4082	210729_RAMP_serum_c18pos_run2_044	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.6; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_044.mzML
SUBJECT_SAMPLE_FACTORS           	4042	210729_RAMP_serum_c18pos_run2_045	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73.7; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_045.mzML
SUBJECT_SAMPLE_FACTORS           	4050	210729_RAMP_serum_c18pos_run2_046	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.8; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_046.mzML
SUBJECT_SAMPLE_FACTORS           	4001	210729_RAMP_serum_c18pos_run2_047	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=72.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_047.mzML
SUBJECT_SAMPLE_FACTORS           	4059	210729_RAMP_serum_c18pos_run2_048	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=65.8; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_048.mzML
SUBJECT_SAMPLE_FACTORS           	4059	210729_RAMP_serum_c18pos_run2_049	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=65.8; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_049.mzML
SUBJECT_SAMPLE_FACTORS           	4063	210729_RAMP_serum_c18pos_run2_050	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_050.mzML
SUBJECT_SAMPLE_FACTORS           	4005	210729_RAMP_serum_c18pos_run2_051	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.3; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_051.mzML
SUBJECT_SAMPLE_FACTORS           	4005	210729_RAMP_serum_c18pos_run2_052	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.3; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_052.mzML
SUBJECT_SAMPLE_FACTORS           	4094	210729_RAMP_serum_c18pos_run2_053	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=77.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_053.mzML
SUBJECT_SAMPLE_FACTORS           	4068	210729_RAMP_serum_c18pos_run2_054	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_054.mzML
SUBJECT_SAMPLE_FACTORS           	4050	210729_RAMP_serum_c18pos_run2_055	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.8; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_055.mzML
SUBJECT_SAMPLE_FACTORS           	4082	210729_RAMP_serum_c18pos_run2_056	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.6; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_056.mzML
SUBJECT_SAMPLE_FACTORS           	4042	210729_RAMP_serum_c18pos_run2_057	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73.7; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_057.mzML
SUBJECT_SAMPLE_FACTORS           	4005	210729_RAMP_serum_c18pos_run2_058	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.3; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_058.mzML
SUBJECT_SAMPLE_FACTORS           	4001	210729_RAMP_serum_c18pos_run2_059	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=72.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_059.mzML
SUBJECT_SAMPLE_FACTORS           	4043	210729_RAMP_serum_c18pos_run2_060	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_060.mzML
SUBJECT_SAMPLE_FACTORS           	4056	210729_RAMP_serum_c18pos_run2_061	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_061.mzML
SUBJECT_SAMPLE_FACTORS           	4048	210729_RAMP_serum_c18pos_run2_062	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=62.6; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_062.mzML
SUBJECT_SAMPLE_FACTORS           	4026	210729_RAMP_serum_c18pos_run2_063	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.3; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_063.mzML
SUBJECT_SAMPLE_FACTORS           	4042	210729_RAMP_serum_c18pos_run2_064	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73.7; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_064.mzML
SUBJECT_SAMPLE_FACTORS           	4036	210729_RAMP_serum_c18pos_run2_065	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_065.mzML
SUBJECT_SAMPLE_FACTORS           	4005	210729_RAMP_serum_c18pos_run2_066	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=69.3; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_066.mzML
SUBJECT_SAMPLE_FACTORS           	4032	210729_RAMP_serum_c18pos_run2_067	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_067.mzML
SUBJECT_SAMPLE_FACTORS           	4042	210729_RAMP_serum_c18pos_run2_068	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=73.7; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_068.mzML
SUBJECT_SAMPLE_FACTORS           	4037	210729_RAMP_serum_c18pos_run2_069	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=75; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_069.mzML
SUBJECT_SAMPLE_FACTORS           	4063	210729_RAMP_serum_c18pos_run2_070	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_070.mzML
SUBJECT_SAMPLE_FACTORS           	4048	210729_RAMP_serum_c18pos_run2_071	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=62.6; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_071.mzML
SUBJECT_SAMPLE_FACTORS           	4028	210729_RAMP_serum_c18pos_run2_072	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_072.mzML
SUBJECT_SAMPLE_FACTORS           	4094	210729_RAMP_serum_c18pos_run2_073	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=77.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_073.mzML
SUBJECT_SAMPLE_FACTORS           	4094	210729_RAMP_serum_c18pos_run2_074	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=77.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_074.mzML
SUBJECT_SAMPLE_FACTORS           	4008	210729_RAMP_serum_c18pos_run2_075	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=83.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_075.mzML
SUBJECT_SAMPLE_FACTORS           	4057	210729_RAMP_serum_c18pos_run2_076	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_076.mzML
SUBJECT_SAMPLE_FACTORS           	4028	210729_RAMP_serum_c18pos_run2_077	Timepoint:4 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_077.mzML
SUBJECT_SAMPLE_FACTORS           	4001	210729_RAMP_serum_c18pos_run2_078	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=72.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_078.mzML
SUBJECT_SAMPLE_FACTORS           	4074	210729_RAMP_serum_c18pos_run2_079	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=68.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_079.mzML
SUBJECT_SAMPLE_FACTORS           	4032	210729_RAMP_serum_c18pos_run2_080	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_080.mzML
SUBJECT_SAMPLE_FACTORS           	4023	210729_RAMP_serum_c18pos_run2_081	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_081.mzML
SUBJECT_SAMPLE_FACTORS           	4037	210729_RAMP_serum_c18pos_run2_082	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=75; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_082.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_083	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_083.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_084	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_084.mzML
SUBJECT_SAMPLE_FACTORS           	4056	210729_RAMP_serum_c18pos_run2_085	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_085.mzML
SUBJECT_SAMPLE_FACTORS           	4063	210729_RAMP_serum_c18pos_run2_086	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=61.4; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_086.mzML
SUBJECT_SAMPLE_FACTORS           	4044	210729_RAMP_serum_c18pos_run2_087	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_087.mzML
SUBJECT_SAMPLE_FACTORS           	4043	210729_RAMP_serum_c18pos_run2_088	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_088.mzML
SUBJECT_SAMPLE_FACTORS           	4056	210729_RAMP_serum_c18pos_run2_089	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=62.1; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_089.mzML
SUBJECT_SAMPLE_FACTORS           	4048	210729_RAMP_serum_c18pos_run2_090	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=62.6; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_090.mzML
SUBJECT_SAMPLE_FACTORS           	4059	210729_RAMP_serum_c18pos_run2_091	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=65.8; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_091.mzML
SUBJECT_SAMPLE_FACTORS           	4043	210729_RAMP_serum_c18pos_run2_092	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_092.mzML
SUBJECT_SAMPLE_FACTORS           	4032	210729_RAMP_serum_c18pos_run2_093	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_093.mzML
SUBJECT_SAMPLE_FACTORS           	4032	210729_RAMP_serum_c18pos_run2_094	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=69; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_094.mzML
SUBJECT_SAMPLE_FACTORS           	4044	210729_RAMP_serum_c18pos_run2_095	Timepoint:3 | Treatment_Group:Placebo | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_095.mzML
SUBJECT_SAMPLE_FACTORS           	4050	210729_RAMP_serum_c18pos_run2_096	Timepoint:3 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.8; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_096.mzML
SUBJECT_SAMPLE_FACTORS           	4026	210729_RAMP_serum_c18pos_run2_097	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.3; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_097.mzML
SUBJECT_SAMPLE_FACTORS           	4057	210729_RAMP_serum_c18pos_run2_098	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_098.mzML
SUBJECT_SAMPLE_FACTORS           	4028	210729_RAMP_serum_c18pos_run2_099	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_099.mzML
SUBJECT_SAMPLE_FACTORS           	4059	210729_RAMP_serum_c18pos_run2_100	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=65.8; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_100.mzML
SUBJECT_SAMPLE_FACTORS           	4082	210729_RAMP_serum_c18pos_run2_101	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=63.6; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_101.mzML
SUBJECT_SAMPLE_FACTORS           	4036	210729_RAMP_serum_c18pos_run2_102	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=66.2; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_102.mzML
SUBJECT_SAMPLE_FACTORS           	4044	210729_RAMP_serum_c18pos_run2_103	Timepoint:1 | Treatment_Group:Placebo | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_103.mzML
SUBJECT_SAMPLE_FACTORS           	4050	210729_RAMP_serum_c18pos_run2_104	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.8; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_104.mzML
SUBJECT_SAMPLE_FACTORS           	4008	210729_RAMP_serum_c18pos_run2_105	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=83.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_105.mzML
SUBJECT_SAMPLE_FACTORS           	4044	210729_RAMP_serum_c18pos_run2_106	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=67.5; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_106.mzML
SUBJECT_SAMPLE_FACTORS           	4094	210729_RAMP_serum_c18pos_run2_107	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=77.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_107.mzML
SUBJECT_SAMPLE_FACTORS           	4023	210729_RAMP_serum_c18pos_run2_108	Timepoint:3 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_108.mzML
SUBJECT_SAMPLE_FACTORS           	4028	210729_RAMP_serum_c18pos_run2_109	Timepoint:1 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=61; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_109.mzML
SUBJECT_SAMPLE_FACTORS           	4068	210729_RAMP_serum_c18pos_run2_110	Timepoint:2 | Treatment_Group:Placebo | Sample source:blood	Age=64.9; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_110.mzML
SUBJECT_SAMPLE_FACTORS           	4043	210729_RAMP_serum_c18pos_run2_111	Timepoint:2 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=64; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_111.mzML
SUBJECT_SAMPLE_FACTORS           	4057	210729_RAMP_serum_c18pos_run2_112	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_112.mzML
SUBJECT_SAMPLE_FACTORS           	4008	210729_RAMP_serum_c18pos_run2_113	Timepoint:4 | Treatment_Group:Placebo | Sample source:blood	Age=83.9; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_113.mzML
SUBJECT_SAMPLE_FACTORS           	4026	210729_RAMP_serum_c18pos_run2_114	Timepoint:4 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.3; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_114.mzML
SUBJECT_SAMPLE_FACTORS           	4023	210729_RAMP_serum_c18pos_run2_115	Timepoint:2 | Treatment_Group:High Dose 2FL | Sample source:blood	Age=60.4; Gender=Male; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_115.mzML
SUBJECT_SAMPLE_FACTORS           	4026	210729_RAMP_serum_c18pos_run2_116	Timepoint:1 | Treatment_Group:Low Dose 2FL | Sample source:blood	Age=62.3; Gender=Female; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_116.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_117	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_117.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_118	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_118.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_119	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_119.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_120	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_120.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_121	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_121.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_122	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_122.mzML
SUBJECT_SAMPLE_FACTORS           	BLANK	210729_RAMP_serum_c18pos_run2_123	Timepoint:BLANK | Treatment_Group:BLANK | Sample source:BLANK	Age=BLANK; Gender=BLANK; Batch_Num=2; RAW_FILE_NAME(raw_file_name)=210729_RAMP_serum_c18pos_run2_123.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	Blood samples were collected during research clinic visits at Weeks -2
CO:COLLECTION_SUMMARY            	(pre-baseline; Timepoint "1" in Study Design metadata), 0 (baseline; Timepoint
CO:COLLECTION_SUMMARY            	"2"), 3 (midpoint of intervention; Timepoint "3"), 6 (end of intervention;
CO:COLLECTION_SUMMARY            	Timepoint "4"). Blood for serum was collected into an SST-tiger top tube, spun
CO:COLLECTION_SUMMARY            	at 1,200xg for 10 minutes, aliquoted, and stored at -80C. Blood for plasma was
CO:COLLECTION_SUMMARY            	collected into an EDTA tube, spun at 1,200xg for 10 minutes, aliquoted, and
CO:COLLECTION_SUMMARY            	stored at -80C.
CO:SAMPLE_TYPE                   	Blood (serum)
#TREATMENT
TR:TREATMENT_SUMMARY             	We recruited a cohort of 89 individuals (mean age = 67.4 years, minimum age = 60
TR:TREATMENT_SUMMARY             	years, maximum age = 83.9 years) and randomized them to one of three arms: a
TR:TREATMENT_SUMMARY             	High Dose 2′-FL arm where subjects consumed 5g 2′-FL per day (n=29), a Low
TR:TREATMENT_SUMMARY             	Dose 2′-FL arm where subjects consumed 1g 2′-FL per day (n=30), and a
TR:TREATMENT_SUMMARY             	Placebo arm where subjects consumed a glucose product free of 2′-FL
TR:TREATMENT_COMPOUND            	2'-fucosyllactose
TR:TREATMENT_ROUTE               	oral
TR:TREATMENT_DOSE                	0 g/day, 1 g/day, or 5 g/day
TR:TREATMENT_DOSEDURATION        	6 weeks
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	All samples were stored at -80oC until use, and were thawed on ice immediately
SP:SAMPLEPREP_SUMMARY            	before extraction. 200 µL of serum for extraction directly without dilution.
SP:SAMPLEPREP_SUMMARY            	Protein precipitation for was conducted by adding 1 mL of extraction buffer (see
SP:SAMPLEPREP_SUMMARY            	composition below) in 100% methanol (LC-MS grade, Fisher) to 200 µL of each
SP:SAMPLEPREP_SUMMARY            	sample in a 2 mL 96-well microplate (Fisher), sealed with a silicone mat
SP:SAMPLEPREP_SUMMARY            	(Agilent), and vortexed to mix. Samples were subsequently incubated at room
SP:SAMPLEPREP_SUMMARY            	temperature for 5 minutes, followed by centrifugation at 5,000 x g for 10
SP:SAMPLEPREP_SUMMARY            	minutes. Two 440 µL aliquots of the same supernatant were transferred to two
SP:SAMPLEPREP_SUMMARY            	separate 2 mL plates and dried under air in a Biotage TurboVap. One of these
SP:SAMPLEPREP_SUMMARY            	dried plates was sealed and archived at -80oC. The dried extracts were
SP:SAMPLEPREP_SUMMARY            	reconstituted in 200 µL reconstitution buffer (see composition below) in 50%
SP:SAMPLEPREP_SUMMARY            	methanol in water (v/v, LC-MS grade, Fisher) by vortexing at max speed for 5
SP:SAMPLEPREP_SUMMARY            	seconds. Reconstituted sample extracts were centrifuged at 2,000 x g for 1
SP:SAMPLEPREP_SUMMARY            	minute, and filtered through a 96-well Durapore PVDF 0.22-um filter plate
SP:SAMPLEPREP_SUMMARY            	(Millipore) into in a 1 mL 96-well plate (Agilent) by centrifugation at 2,000 x
SP:SAMPLEPREP_SUMMARY            	g for 10 minutes. Plates were then sealed with 96-well cap mats (Agilent) and
SP:SAMPLEPREP_SUMMARY            	stored at -80oC until LC-MS analysis. QC samples were generated by pooling 4 µL
SP:SAMPLEPREP_SUMMARY            	from each well of the experiment into a single designated well on the same plate
SP:SAMPLEPREP_SUMMARY            	for LC-MS analysis. The extraction buffer consisted of 4-Chloro-phenylalanine
SP:SAMPLEPREP_SUMMARY            	(6.8 µM, Carbosynth), Tridecanoic acid (6.8 µM, Sigma), and
SP:SAMPLEPREP_SUMMARY            	2-Flurophenylglycine (3.4 µM, SCBT) in 100% methanol. The reconstitution buffer
SP:SAMPLEPREP_SUMMARY            	included the internal standards: Phenylalanine-2,3,4,5,6-d5 (12.5 µM, CIL),
SP:SAMPLEPREP_SUMMARY            	Glucose-1,2,3,4,5,6,6-d7 (25 µM, CIL), Methionine-methyl-d3 (12.5 µM, CIL),
SP:SAMPLEPREP_SUMMARY            	4-Hydroxyphenyl-d4-alanine (3.125 µM, CDN), Tryptophan-2,4,5,6,7-d5 (12.5 µM,
SP:SAMPLEPREP_SUMMARY            	CDN), Leucine-5,5,5-d3 (12.5 µM, CDN), N-Benzoyl-d5-glycine (6.25 µM, CDN),
SP:SAMPLEPREP_SUMMARY            	4-Bromophenylalanine (12.5 µM, Sigma), Progesterone-d9 (3.125 µM, CIL),
SP:SAMPLEPREP_SUMMARY            	Di-N-octyl phthalate3,4,5,6-d4 (12.5 µM, CDN), d19-Decanoic acid (12.5 µM,
SP:SAMPLEPREP_SUMMARY            	CDN), d15-Octanoic acid (25 µM, CDN), Indole-2,4,5,6,7-d5-3-acetic acid (12.5
SP:SAMPLEPREP_SUMMARY            	µM, CDN), Carnitine-trimethyl-d9 (3.125 µM, CDN), and d27-Tetradecanoic acid
SP:SAMPLEPREP_SUMMARY            	(12.5 µM, CDN), in 50% methanol in water.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Agilent 6530
CH:COLUMN_NAME                   	Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um)
CH:SOLVENT_A                     	100% Water
CH:SOLVENT_B                     	100% Methanol
CH:FLOW_GRADIENT                 	0.5% B to 70% B in 4 minutes, from 70% B to 98% B in 0.5 minutes, and holding at
CH:FLOW_GRADIENT                 	98% B for 0.9 minute before returning to 0.5% B in 0.2 minutes.
CH:FLOW_RATE                     	0.35 mL/min
CH:COLUMN_TEMPERATURE            	40
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
AN:ACQUISITION_DATE              	20210729
#MS
MS:INSTRUMENT_NAME               	Agilent 6545 QTOF
MS:INSTRUMENT_TYPE               	QTOF
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	For all analytical methods, data were collected at a mass range of 70-1000 m/z
MS:MS_COMMENTS                   	at an acquisition rate of 2 spectra per second. Specific ion source parameters
MS:MS_COMMENTS                   	included Fragmentor (140V), Gas Temp (250o C), Sheath Gas Temp (200o C), and
MS:MS_COMMENTS                   	VCap (4000V).
MS:CAPILLARY_VOLTAGE             	4000
MS:DRY_GAS_TEMP                  	250
MS:FRAGMENT_VOLTAGE              	140
MS:MS_RESULTS_FILE               	ST003874_AN006365_Results.txt	UNITS:Peak area	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END