#METABOLOMICS WORKBENCH ZhigangRao_uibk_20250417_060414 DATATRACK_ID:5847 STUDY_ID:ST003876 ANALYSIS_ID:AN006368 PROJECT_ID:PR002430 VERSION 1 CREATED_ON April 17, 2025, 6:47 am #PROJECT PR:PROJECT_TITLE Alkyglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent PR:PROJECT_TITLE manner PR:PROJECT_SUMMARY Ether lipids are major constituents of biomembranes and often contain PR:PROJECT_SUMMARY polyunsaturated fatty acids at the sn-2 position, implicating them in cellular PR:PROJECT_SUMMARY signaling and inflammatory processes. Alkylglycerol monooxygenase is the only PR:PROJECT_SUMMARY enzyme capable of cleaving alkylglycerols, an ether lipid subclass, but its PR:PROJECT_SUMMARY exact role and that of its substrates remain unclear. Here, we demonstrate a PR:PROJECT_SUMMARY sex- and cell type-dependent role of alkylglycerol monooxygenase in limiting PR:PROJECT_SUMMARY prostanoid formation without affecting polyunsaturated fatty acid release, as PR:PROJECT_SUMMARY revealed by metabololipidomics profiling. This female-specific effect is driven PR:PROJECT_SUMMARY by the suppression of prostaglandin G/H synthase 2 transcription, as deficiency PR:PROJECT_SUMMARY in alkylglycerol monooxygenase significantly elevated prostaglandin G/H synthase PR:PROJECT_SUMMARY 2 expression in female bone marrow-derived macrophages of the M1 phenotype. PR:PROJECT_SUMMARY Furthermore, this regulatory role of alkylglycerol monooxygenase extends to PR:PROJECT_SUMMARY visceral white adipose tissue, where elevated prostaglandin G/H synthase 2 PR:PROJECT_SUMMARY expression and enhanced prostaglandin production were observed in female samples PR:PROJECT_SUMMARY following alkylglycerol monooxygenase knockout. Collectively, our results expand PR:PROJECT_SUMMARY the immunomodulatory functions of ether lipid metabolism and highlight the role PR:PROJECT_SUMMARY of alkylglycerol monooxygenase in controlling lipid mediator production and PR:PROJECT_SUMMARY maintaining tissue homeostasis. PR:INSTITUTE University of Innsbruck PR:DEPARTMENT Michael Popp Institute PR:LAST_NAME Rao PR:FIRST_NAME Zhigang PR:ADDRESS Mitetrweg 24, Innsbruck, Tyrol, 6020, Austria PR:EMAIL rzgwuda@gmail.com PR:PHONE +43 662 8044 5581 PR:PUBLICATIONS in revision PR:CONTRIBUTORS Zhigang Rao, Andreas Koeberle #STUDY ST:STUDY_TITLE Exploration of AGMO-dependent changes in the lipid mediator profile of polarized ST:STUDY_TITLE BMDM cells (M0, M1 and M2 phenoptypes) ST:STUDY_SUMMARY Murine BMDMs isolated from wildtype (WT) or Agmo knockout (KO) mice were ST:STUDY_SUMMARY polarized to the M0, M1 or M2 phenotypes, and then incubated in PBS + Ca2+ (1 ST:STUDY_SUMMARY mM) for 3 h. Lipid mediators were extracted and analyzed by UPLC-MS/MS. ST:INSTITUTE University of Innsbruck ST:LAST_NAME Rao ST:FIRST_NAME Zhigang ST:ADDRESS Mitterweg 24, Innsbruck, Tyrol, 6020, Austria ST:EMAIL rzgwuda@gmail.com ST:PHONE +43 662 8044 5581 ST:NUM_GROUPS 2 (wild type and AGMO knockout) ST:TOTAL_SUBJECTS 17 ST:NUM_MALES 9 ST:NUM_FEMALES 8 ST:PUBLICATIONS in revision #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M0_WT veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M0_TG1 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M0_TG2 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M1_WT veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M1_TG1 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M1_TG2 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M2_WT veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M2_TG1 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M2_TG2 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M0_WT SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M0_TG1 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M0_TG2 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M1_WT SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M1_TG1 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M1_TG2 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M2_WT SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M2_TG1 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M2_TG2 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M0_WT A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M0_TG1 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M0_TG2 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M1_WT A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M1_TG1 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M1_TG2 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 1 210512_BMDM_0415 M2_WT A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 2 210512_BMDM_0415 M2_TG1 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 3 210512_BMDM_0415 M2_TG2 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210512_210429_BMDM_AGMO_1-27.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M0_WT1 veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M0_TG1 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M1_WT veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M1_TG1 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M2_WT veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M2_TG1 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M0_WT2 veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M0_TG2 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M1_WT2 veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M1_TG2 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M2_WT2 veh Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M2_TG2 veh Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M0_WT1 SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M0_TG1 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M1_WT SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M1_TG1 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M2_WT SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M2_TG1 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M0_WT2 SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M0_TG2 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M1_WT2 SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M1_TG2 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M2_WT2 SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M2_TG2 SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M0_WT1 A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M0_TG1 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M1_WT A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M1_TG1 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 4 210512_BMDM_0430 M2_WT A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 5 210512_BMDM_0430 M2_TG1 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M0_WT2 A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M0_TG2 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M1_WT2 A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M1_TG2 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 6 210512_BMDM_0430 M2_WT2 A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 7 210512_BMDM_0430 M2_TG2 A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210528_AGMO_BMDM_0430.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M0_WT_veh_AGMO_Rao_1 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M0_TG_veh_AGMO_Rao_2 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M1_WT_veh_AGMO_Rao_3 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M1_TG_veh_AGMO_Rao_4 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M2_WT_veh_AGMO_Rao_5 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M2_TG_veh_AGMO_Rao_6 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M0_WT_veh_AGMO_Rao_7 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M1_WT_veh_AGMO_Rao_8 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M2_WT_veh_AGMO_Rao_9 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M0_WT_SACM_AGMO_Rao_10 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M0_TG_SACM_AGMO_Rao_11 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M1_WT_SACM_AGMO_Rao_12 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M1_TG_SACM_AGMO_Rao_13 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M2_WT_SACM_AGMO_Rao_14 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M2_TG_SACM_AGMO_Rao_15 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M0_WT_SACM_AGMO_Rao_16 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M1_WT_SACM_AGMO_Rao_17 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M2_WT_SACM_AGMO_Rao_18 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M0_WT_A23187_AGMO_Rao_19 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M0_TG_A23187_AGMO_Rao_20 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M1_WT_A23187_AGMO_Rao_21 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M1_TG_A23187_AGMO_Rao_22 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 8 210709_BMDM_male_M2_WT_A23187_AGMO_Rao_23 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 9 210709_BMDM_male_M2_TG_A23187_AGMO_Rao_24 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M0_WT_A23187_AGMO_Rao_25 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M1_WT_A23187_AGMO_Rao_26 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 10 210709_BMDM_female_M2_WT_A23187_AGMO_Rao_27 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210723_BMDM_AGMO_Rao.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M0_WT_veh_AGMO_Rao_1 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M0_TG_veh_AGMO_Rao_2 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M1_WT_veh_AGMO_Rao_3 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M1_TG_veh_AGMO_Rao_4 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M2_WT_veh_AGMO_Rao_5 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M2_TG_veh_AGMO_Rao_6 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M0_WT_veh_AGMO_Rao_7 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M0_TG_veh_AGMO_Rao_8 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M1_WT_veh_AGMO_Rao_9 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M1_TG_veh_AGMO_Rao_10 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M2_WT_veh_AGMO_Rao_11 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M2_TG_veh_AGMO_Rao_12 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M0_WT_SACM_AGMO_Rao_13 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M0_TG_SACM_AGMO_Rao_14 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M1_WT_SACM_AGMO_Rao_15 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M1_TG_SACM_AGMO_Rao_16 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M2_WT_SACM_AGMO_Rao_17 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M2_TG_SACM_AGMO_Rao_18 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M0_WT_SACM_AGMO_Rao_19 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M0_TG_SACM_AGMO_Rao_20 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M1_WT_SACM_AGMO_Rao_21 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M1_TG_SACM_AGMO_Rao_22 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M2_WT_SACM_AGMO_Rao_23 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M2_TG_SACM_AGMO_Rao_24 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M0_WT_A23187_AGMO_Rao_25 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M0_TG_A23187_AGMO_Rao_26 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M1_WT_A23187_AGMO_Rao_27 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M1_TG_A23187_AGMO_Rao_28 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 11 210805_BMDM_male_M2_WT_A23187_AGMO_Rao_29 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 12 210805_BMDM_male_M2_TG_A23187_AGMO_Rao_30 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M0_WT_A23187_AGMO_Rao_31 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M0_TG_A23187_AGMO_Rao_32 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M1_WT_A23187_AGMO_Rao_33 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M1_TG_A23187_AGMO_Rao_34 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 13 210805_BMDM_male_M2_WT_A23187_AGMO_Rao_35 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 14 210805_BMDM_male_M2_TG_A23187_AGMO_Rao_36 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=210825_RAO_BMDM_AGMO_1-36.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M0_WT1 veh_ 1 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M0_WT2 veh_ 2 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M0_TG1 veh_ 3 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M1_WT1 veh_ 4 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M1_WT2 veh_ 5 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M1_TG1 veh_ 6 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M2_WT1 veh_ 7 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M2_WT2 veh_ 8 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M2_TG1 veh_ 9 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Treatment Time=-; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M0_WT1 SACM_ 10 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M0_WT2 SACM_ 11 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M0_TG1 SACM_ 12 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M1_WT1 SACM_ 13 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M1_WT2 SACM_ 14 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M1_TG1 SACM_ 15 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M2_WT1 SACM_ 16 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M2_WT2 SACM_ 17 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M2_TG1 SACM_ 18 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Treatment Time=3 h; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M0_WT1 A23187_ 19 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M0_WT2 A23187_ 20 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M0_TG1 A23187_ 21 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M1_WT1 A23187_ 22 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M1_WT2 A23187_ 23 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M1_TG1 A23187_ 24 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 15 211222_BMDM_AGMO_male_M2_WT1 A23187_ 25 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 16 211222_BMDM_AGMO_male_M2_WT2 A23187_ 26 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff SUBJECT_SAMPLE_FACTORS 17 211222_BMDM_AGMO_male_M2_TG1 A23187_ 27 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Treatment Time=15 min; RAW_FILE_NAME(Raw file name (Analyst file name))=211222_AGMO BMDM.wiff #COLLECTION CO:COLLECTION_SUMMARY Murine BMDMs isolated from wildtype or Agmo knockout mice were polarized to the CO:COLLECTION_SUMMARY M0, M1 or M2 phenotypes, and then incubated in PBS + Ca2+ (1 mM) for 3 h. CO:COLLECTION_SUMMARY Supernatants were collected for solid phase extraction before subjection to CO:COLLECTION_SUMMARY lipid mediator analysis. CO:SAMPLE_TYPE Macrophages CO:STORAGE_CONDITIONS -80℃ #TREATMENT TR:TREATMENT_SUMMARY Murine BMDMs isolated from wildtype or Agmo knockout mice were polarized to the TR:TREATMENT_SUMMARY M0, M1 or M2 phenotypes, and then stimulated with Staphylococcus TR:TREATMENT_SUMMARY aureus-conditioned medium (SACM, 1%, 3 h) or A23187 (2.5 µM, 15 min) in PBS + TR:TREATMENT_SUMMARY Ca2+ (1 mM) for the indicated time. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Cell supernatants (1.5 mL) or tissue homogenates (150 µL) were mixed with SP:SAMPLEPREP_SUMMARY ice-cold methanol (3 mL) containing the deuterated internal standards SP:SAMPLEPREP_SUMMARY d8-5S-HETE, d4-LTB4, d5-LXA4, d5-RvD2, d4-PGE2 (20 pg/µL, 10 µL each, Cayman SP:SAMPLEPREP_SUMMARY Chemicals, Ann Arbor, MI) and d8-arachidonic acid (200 pg/µL, 10 µL, Cayman SP:SAMPLEPREP_SUMMARY Chemicals). The sample mixtures were first kept at -20 °C for more than 2 h to SP:SAMPLEPREP_SUMMARY allow protein precipitation, and then centrifuged (1200 × g, 10 min, 4 °C). SP:SAMPLEPREP_SUMMARY Supernatants were transferred to new vials and mixed with 8 mL of acidified SP:SAMPLEPREP_SUMMARY water (pH = 3.5) before loading onto Sep-Pak C18 6cc Vac Cartridges (500 mg; SP:SAMPLEPREP_SUMMARY Waters, Milford, MA) (Neukirch et al. 2021) pre-equilibrated with 6 mL methanol SP:SAMPLEPREP_SUMMARY and 2 mL water. After several washing steps with water (6 mL) and n-hexane (6 SP:SAMPLEPREP_SUMMARY mL), lipid mediators were eluted with methyl formate. The eluate was brought to SP:SAMPLEPREP_SUMMARY dryness using a TurboVap system (TurboVap LV, Biotage, Uppsala, Sweden) under SP:SAMPLEPREP_SUMMARY nitrogen flow at 30 oC. The dried lipid film was dissolved in methanol/water SP:SAMPLEPREP_SUMMARY (50/50, v/v) and analyzed by ultra-performance liquid chromatography‒tandem SP:SAMPLEPREP_SUMMARY mass spectrometry (UPLC-MS/MS). SP:PROCESSING_STORAGE_CONDITIONS -20℃ SP:EXTRACT_STORAGE -80℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Chromatographic separation of phospholipids was carried out on an Acquity BEH CH:CHROMATOGRAPHY_SUMMARY C18 column (ACQUITY UPLC® BEH C18; 1.7 µm; 2.1 mm × 100 mm; Waters) using an CH:CHROMATOGRAPHY_SUMMARY Exion LC system (Sciex, Darmstadt, Germany). CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Waters Acquity H-Class CH:COLUMN_NAME Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um) CH:SOLVENT_A 10% methanol, 90% water, 0.01% acetic acid CH:SOLVENT_B 100% methanol + 0.01% acetic acid CH:FLOW_GRADIENT The gradient was ramped from 35.6% B to 84.4% B over 12.5 min, then to 97.8% B CH:FLOW_GRADIENT and maintained for another 5 min, and finally isocratically set to 35.6% B for CH:FLOW_GRADIENT 2.5 min. CH:FLOW_RATE 0.35 ml/min CH:COLUMN_TEMPERATURE 55°C #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex 6500+ QTrap MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Mass spectra were acquired using Analyst 1.7.1 (Sciex) and processed with MS:MS_COMMENTS Analyst 1.6.3 (Sciex), where the retention time was defined with the help of MS:MS_COMMENTS external lipid standards. The absolute amount of lipid mediators was calculated MS:MS_COMMENTS from integrated signal intensities that were 1) normalized using the deuterated MS:MS_COMMENTS internal standards, 2) corrected by external calibration (linear regression MS:MS_COMMENTS based on 11 dilutions), and 3) divided by the amount of protein in cell lysates. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS absolute intensity (pg) MS_METABOLITE_DATA_START Samples 210512_BMDM_0415 M0_WT veh 210512_BMDM_0415 M0_TG1 veh 210512_BMDM_0415 M0_TG2 veh 210512_BMDM_0415 M1_WT veh 210512_BMDM_0415 M1_TG1 veh 210512_BMDM_0415 M1_TG2 veh 210512_BMDM_0415 M2_WT veh 210512_BMDM_0415 M2_TG1 veh 210512_BMDM_0415 M2_TG2 veh 210512_BMDM_0415 M0_WT SACM 210512_BMDM_0415 M0_TG1 SACM 210512_BMDM_0415 M0_TG2 SACM 210512_BMDM_0415 M1_WT SACM 210512_BMDM_0415 M1_TG1 SACM 210512_BMDM_0415 M1_TG2 SACM 210512_BMDM_0415 M2_WT SACM 210512_BMDM_0415 M2_TG1 SACM 210512_BMDM_0415 M2_TG2 SACM 210512_BMDM_0415 M0_WT A23187 210512_BMDM_0415 M0_TG1 A23187 210512_BMDM_0415 M0_TG2 A23187 210512_BMDM_0415 M1_WT A23187 210512_BMDM_0415 M1_TG1 A23187 210512_BMDM_0415 M1_TG2 A23187 210512_BMDM_0415 M2_WT A23187 210512_BMDM_0415 M2_TG1 A23187 210512_BMDM_0415 M2_TG2 A23187 210512_BMDM_0430 M0_WT1 veh 210512_BMDM_0430 M0_TG1 veh 210512_BMDM_0430 M1_WT veh 210512_BMDM_0430 M1_TG1 veh 210512_BMDM_0430 M2_WT veh 210512_BMDM_0430 M2_TG1 veh 210512_BMDM_0430 M0_WT2 veh 210512_BMDM_0430 M0_TG2 veh 210512_BMDM_0430 M1_WT2 veh 210512_BMDM_0430 M1_TG2 veh 210512_BMDM_0430 M2_WT2 veh 210512_BMDM_0430 M2_TG2 veh 210512_BMDM_0430 M0_WT1 SACM 210512_BMDM_0430 M0_TG1 SACM 210512_BMDM_0430 M1_WT SACM 210512_BMDM_0430 M1_TG1 SACM 210512_BMDM_0430 M2_WT SACM 210512_BMDM_0430 M2_TG1 SACM 210512_BMDM_0430 M0_WT2 SACM 210512_BMDM_0430 M0_TG2 SACM 210512_BMDM_0430 M1_WT2 SACM 210512_BMDM_0430 M1_TG2 SACM 210512_BMDM_0430 M2_WT2 SACM 210512_BMDM_0430 M2_TG2 SACM 210512_BMDM_0430 M0_WT1 A23187 210512_BMDM_0430 M0_TG1 A23187 210512_BMDM_0430 M1_WT A23187 210512_BMDM_0430 M1_TG1 A23187 210512_BMDM_0430 M2_WT A23187 210512_BMDM_0430 M2_TG1 A23187 210512_BMDM_0430 M0_WT2 A23187 210512_BMDM_0430 M0_TG2 A23187 210512_BMDM_0430 M1_WT2 A23187 210512_BMDM_0430 M1_TG2 A23187 210512_BMDM_0430 M2_WT2 A23187 210512_BMDM_0430 M2_TG2 A23187 210709_BMDM_male_M0_WT_veh_AGMO_Rao_1 210709_BMDM_male_M0_TG_veh_AGMO_Rao_2 210709_BMDM_male_M1_WT_veh_AGMO_Rao_3 210709_BMDM_male_M1_TG_veh_AGMO_Rao_4 210709_BMDM_male_M2_WT_veh_AGMO_Rao_5 210709_BMDM_male_M2_TG_veh_AGMO_Rao_6 210709_BMDM_female_M0_WT_veh_AGMO_Rao_7 210709_BMDM_female_M1_WT_veh_AGMO_Rao_8 210709_BMDM_female_M2_WT_veh_AGMO_Rao_9 210709_BMDM_male_M0_WT_SACM_AGMO_Rao_10 210709_BMDM_male_M0_TG_SACM_AGMO_Rao_11 210709_BMDM_male_M1_WT_SACM_AGMO_Rao_12 210709_BMDM_male_M1_TG_SACM_AGMO_Rao_13 210709_BMDM_male_M2_WT_SACM_AGMO_Rao_14 210709_BMDM_male_M2_TG_SACM_AGMO_Rao_15 210709_BMDM_female_M0_WT_SACM_AGMO_Rao_16 210709_BMDM_female_M1_WT_SACM_AGMO_Rao_17 210709_BMDM_female_M2_WT_SACM_AGMO_Rao_18 210709_BMDM_male_M0_WT_A23187_AGMO_Rao_19 210709_BMDM_male_M0_TG_A23187_AGMO_Rao_20 210709_BMDM_male_M1_WT_A23187_AGMO_Rao_21 210709_BMDM_male_M1_TG_A23187_AGMO_Rao_22 210709_BMDM_male_M2_WT_A23187_AGMO_Rao_23 210709_BMDM_male_M2_TG_A23187_AGMO_Rao_24 210709_BMDM_female_M0_WT_A23187_AGMO_Rao_25 210709_BMDM_female_M1_WT_A23187_AGMO_Rao_26 210709_BMDM_female_M2_WT_A23187_AGMO_Rao_27 210805_BMDM_male_M0_WT_veh_AGMO_Rao_1 210805_BMDM_male_M0_TG_veh_AGMO_Rao_2 210805_BMDM_male_M1_WT_veh_AGMO_Rao_3 210805_BMDM_male_M1_TG_veh_AGMO_Rao_4 210805_BMDM_male_M2_WT_veh_AGMO_Rao_5 210805_BMDM_male_M2_TG_veh_AGMO_Rao_6 210805_BMDM_male_M0_WT_veh_AGMO_Rao_7 210805_BMDM_male_M0_TG_veh_AGMO_Rao_8 210805_BMDM_male_M1_WT_veh_AGMO_Rao_9 210805_BMDM_male_M1_TG_veh_AGMO_Rao_10 210805_BMDM_male_M2_WT_veh_AGMO_Rao_11 210805_BMDM_male_M2_TG_veh_AGMO_Rao_12 210805_BMDM_male_M0_WT_SACM_AGMO_Rao_13 210805_BMDM_male_M0_TG_SACM_AGMO_Rao_14 210805_BMDM_male_M1_WT_SACM_AGMO_Rao_15 210805_BMDM_male_M1_TG_SACM_AGMO_Rao_16 210805_BMDM_male_M2_WT_SACM_AGMO_Rao_17 210805_BMDM_male_M2_TG_SACM_AGMO_Rao_18 210805_BMDM_male_M0_WT_SACM_AGMO_Rao_19 210805_BMDM_male_M0_TG_SACM_AGMO_Rao_20 210805_BMDM_male_M1_WT_SACM_AGMO_Rao_21 210805_BMDM_male_M1_TG_SACM_AGMO_Rao_22 210805_BMDM_male_M2_WT_SACM_AGMO_Rao_23 210805_BMDM_male_M2_TG_SACM_AGMO_Rao_24 210805_BMDM_male_M0_WT_A23187_AGMO_Rao_25 210805_BMDM_male_M0_TG_A23187_AGMO_Rao_26 210805_BMDM_male_M1_WT_A23187_AGMO_Rao_27 210805_BMDM_male_M1_TG_A23187_AGMO_Rao_28 210805_BMDM_male_M2_WT_A23187_AGMO_Rao_29 210805_BMDM_male_M2_TG_A23187_AGMO_Rao_30 210805_BMDM_male_M0_WT_A23187_AGMO_Rao_31 210805_BMDM_male_M0_TG_A23187_AGMO_Rao_32 210805_BMDM_male_M1_WT_A23187_AGMO_Rao_33 210805_BMDM_male_M1_TG_A23187_AGMO_Rao_34 210805_BMDM_male_M2_WT_A23187_AGMO_Rao_35 210805_BMDM_male_M2_TG_A23187_AGMO_Rao_36 211222_BMDM_AGMO_male_M0_WT1 veh_ 1 211222_BMDM_AGMO_male_M0_WT2 veh_ 2 211222_BMDM_AGMO_male_M0_TG1 veh_ 3 211222_BMDM_AGMO_male_M1_WT1 veh_ 4 211222_BMDM_AGMO_male_M1_WT2 veh_ 5 211222_BMDM_AGMO_male_M1_TG1 veh_ 6 211222_BMDM_AGMO_male_M2_WT1 veh_ 7 211222_BMDM_AGMO_male_M2_WT2 veh_ 8 211222_BMDM_AGMO_male_M2_TG1 veh_ 9 211222_BMDM_AGMO_male_M0_WT1 SACM_ 10 211222_BMDM_AGMO_male_M0_WT2 SACM_ 11 211222_BMDM_AGMO_male_M0_TG1 SACM_ 12 211222_BMDM_AGMO_male_M1_WT1 SACM_ 13 211222_BMDM_AGMO_male_M1_WT2 SACM_ 14 211222_BMDM_AGMO_male_M1_TG1 SACM_ 15 211222_BMDM_AGMO_male_M2_WT1 SACM_ 16 211222_BMDM_AGMO_male_M2_WT2 SACM_ 17 211222_BMDM_AGMO_male_M2_TG1 SACM_ 18 211222_BMDM_AGMO_male_M0_WT1 A23187_ 19 211222_BMDM_AGMO_male_M0_WT2 A23187_ 20 211222_BMDM_AGMO_male_M0_TG1 A23187_ 21 211222_BMDM_AGMO_male_M1_WT1 A23187_ 22 211222_BMDM_AGMO_male_M1_WT2 A23187_ 23 211222_BMDM_AGMO_male_M1_TG1 A23187_ 24 211222_BMDM_AGMO_male_M2_WT1 A23187_ 25 211222_BMDM_AGMO_male_M2_WT2 A23187_ 26 211222_BMDM_AGMO_male_M2_TG1 A23187_ 27 Factors Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:female | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:- Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:SACM Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:wildtype | sex:male | Treatment:A23187 Sample source:Murine BMDMs | Geenotype:AGMO knockout | sex:male | Treatment:A23187 17S-HDHA 35.0 46.2 32.3 18.6 35.6 54.5 34.7 31.9 20.1 130.4 85.3 116.6 77.0 66.0 68.4 43.9 14.8 23.6 49.8 48.0 30.0 25.0 219.7 14.9 14.4 6.8 22.1 5.5 21.9 36.3 46.5 5.7 7.4 13.1 12.9 22.8 32.5 4.0 1.2 96.4 64.1 44.2 77.1 45.7 45.2 88.6 94.0 69.3 93.1 31.8 27.6 7.5 23.7 27.3 43.3 4.1 13.3 12.2 8.6 8.5 12.7 9.6 0.0 0.0 10.6 4.6 2.7 0.0 1.0 8.1 3.9 0.0 22.4 81.0 22.0 48.0 6.3 5.1 55.2 26.6 2.8 3.3 16.1 0.0 10.5 0.0 8.3 7.4 0.0 0.0 7.0 14.0 2.6 8.6 5.4 11.7 10.3 7.3 7.7 23.8 1.7 0.0 79.2 109.7 55.6 57.8 11.9 100.7 55.4 108.8 90.8 22.2 23.2 22.5 9.7 12.7 11.6 2.1 5.4 4.2 0.0 12.2 14.6 3.9 0.4 0.0 18.7 26.0 7.3 75.7 34.4 35.0 7.5 1.9 14.2 64.0 69.4 76.2 147.3 43.9 62.2 26.8 41.4 35.4 39.7 43.3 30.4 79.1 5.9 13.2 25.3 12.6 5.3 14S-HDHA 6.2 9.8 6.3 1.6 8.9 5.0 4.1 2.1 2.1 52.5 21.5 35.7 16.9 16.7 16.2 20.1 2.9 7.7 6.3 11.1 9.2 4.9 45.3 2.9 2.6 5.6 2.6 1.2 5.3 3.5 7.3 2.2 1.7 0.9 1.9 0.7 2.4 1.1 0.6 40.5 21.3 11.1 15.7 12.7 7.4 37.0 29.5 19.0 21.3 11.3 6.9 1.9 4.0 5.6 4.4 0.2 0.3 1.8 3.0 2.5 0.4 5.9 4.4 1.2 3.2 0.0 1.6 0.7 0.0 0.0 0.4 0.1 4.8 29.8 3.2 4.7 2.0 1.1 20.4 3.0 0.5 0.7 3.6 0.0 0.1 0.0 2.8 0.2 0.0 0.0 2.4 2.3 0.0 0.0 0.0 6.5 2.0 1.9 1.2 4.2 0.0 0.1 28.0 25.2 12.8 20.8 1.1 27.8 15.5 37.0 19.3 6.4 7.0 1.1 0.0 0.6 0.9 0.4 0.3 0.0 30.3 1.5 0.5 0.0 0.0 0.0 5.5 2.5 11.8 13.7 2.5 4.0 0.2 2.6 0.7 16.6 19.3 13.2 10.4 8.8 8.6 8.0 6.4 0.0 9.2 3.4 6.6 2.5 2.3 7.9 0.0 0.7 0.5 17-HDPA* 34.5 46.6 34.2 24.9 47.1 32.3 25.6 11.4 14.7 112.6 85.4 83.5 47.9 82.4 69.4 62.1 26.6 31.3 38.9 63.4 37.5 19.9 133.9 24.1 17.7 14.2 18.8 17.4 32.5 27.1 37.9 7.5 9.7 13.1 22.5 22.1 24.8 7.1 5.4 73.0 56.3 47.2 78.9 46.3 34.3 76.1 54.7 88.8 103.3 35.0 30.2 15.3 32.3 34.7 52.5 10.1 16.2 19.0 23.0 31.3 19.0 10.6 3.1 8.8 28.8 12.3 26.2 2.1 2.9 11.8 15.6 3.3 14.4 70.5 35.7 68.6 11.6 13.0 44.8 47.1 12.2 8.4 28.7 12.5 27.2 1.4 9.1 9.2 17.9 6.7 13.6 13.1 12.6 14.8 4.6 12.4 17.5 18.8 21.0 22.1 4.7 6.1 45.2 42.8 72.9 37.3 15.4 16.8 44.5 44.1 31.0 44.4 11.5 21.6 17.9 11.2 13.3 11.7 5.1 5.3 75.2 20.0 22.4 8.6 6.3 3.8 35.9 37.6 50.3 140.3 45.8 50.2 6.2 15.9 5.9 89.0 91.4 108.1 185.3 103.3 119.2 35.5 63.9 54.5 57.2 41.3 41.2 141.7 39.7 58.8 15.5 10.2 12.0 14-HDPA* 27.9 36.9 22.1 12.5 21.5 14.4 9.0 7.9 5.5 103.9 67.5 73.2 31.9 36.2 45.9 39.0 9.0 15.8 23.4 55.3 29.0 13.0 56.5 14.1 5.7 1.7 5.9 6.8 17.6 12.5 11.7 3.5 1.8 7.4 9.4 12.1 10.3 2.4 2.7 62.9 48.4 32.1 29.9 33.7 20.5 55.6 46.5 42.5 41.9 27.0 17.6 5.1 19.2 13.8 15.5 1.1 1.6 6.0 9.5 11.5 5.5 6.7 2.1 5.0 18.9 9.9 11.1 1.0 0.0 4.4 13.3 0.9 19.8 56.3 22.9 22.2 5.8 4.3 41.3 23.3 6.2 3.8 20.1 9.6 6.7 1.3 3.7 5.5 11.7 0.9 8.7 5.2 3.8 2.7 0.8 8.7 5.9 10.4 6.1 3.7 0.9 0.1 39.1 35.0 43.8 20.7 1.7 5.1 34.9 38.2 14.7 27.2 3.6 3.3 8.3 6.2 5.7 5.5 0.7 0.2 47.2 12.4 4.8 0.0 1.4 0.2 35.0 35.0 32.3 46.2 27.9 14.6 8.0 10.1 4.5 88.4 86.6 86.5 67.9 55.4 39.4 36.5 37.0 26.0 47.0 42.9 30.8 44.6 13.2 17.8 8.6 5.1 1.8 15-HEPE 18.5 17.1 13.0 11.4 21.7 19.3 13.2 16.8 12.7 29.1 18.6 22.0 21.9 19.8 18.2 22.0 11.9 17.9 23.4 19.9 17.0 12.2 50.6 21.6 11.3 15.4 20.1 14.4 14.0 10.9 12.0 5.6 16.0 22.3 14.2 19.0 20.2 4.7 5.5 37.7 28.4 19.1 23.1 32.8 24.6 52.4 53.2 37.2 34.9 37.7 38.4 14.5 9.8 13.6 15.9 5.6 13.6 20.1 21.7 15.1 13.7 5.7 2.3 7.5 15.6 12.0 17.0 3.1 5.0 9.2 13.6 2.2 18.3 26.7 29.4 36.5 11.0 11.5 41.6 35.2 9.7 8.9 12.2 11.3 15.0 1.8 2.8 10.0 15.1 4.0 11.8 11.2 12.5 18.1 2.4 5.5 10.1 10.4 10.7 9.2 2.3 3.3 34.3 43.5 37.4 25.1 5.8 7.6 37.3 49.2 26.2 32.5 7.5 13.6 14.6 20.3 18.7 6.4 8.7 3.3 0.0 11.7 12.5 82.3 4.4 7.9 7.6 16.3 17.4 19.7 16.5 7.6 6.6 6.1 2.1 20.9 31.5 30.9 33.0 32.7 2.9 23.7 15.1 0.0 22.4 23.1 27.5 14.5 22.8 1.4 2.4 7.2 5.0 12-HEPE 12.8 11.1 8.0 7.3 6.0 7.8 5.0 5.7 4.2 19.9 10.9 14.7 15.0 8.4 10.6 14.2 4.8 9.1 10.8 10.4 8.5 6.7 12.6 6.4 5.9 3.9 7.2 7.6 6.3 5.0 4.4 6.3 2.0 9.6 4.8 5.9 7.3 4.7 5.5 25.7 16.0 10.6 9.1 20.6 12.5 33.5 25.1 19.4 18.6 25.8 25.8 5.9 4.9 4.8 4.2 4.7 5.2 8.2 8.7 5.7 4.2 5.4 1.9 7.6 6.0 12.4 7.8 3.1 5.2 8.8 14.4 3.0 16.6 18.1 30.4 19.6 11.1 7.6 47.8 26.1 8.6 8.5 6.8 12.9 7.3 3.6 4.5 7.7 12.6 2.6 9.2 10.4 8.2 13.8 3.3 4.2 7.7 9.3 10.6 8.8 4.0 3.0 21.2 27.4 25.8 20.0 6.5 8.2 26.2 34.8 28.9 24.7 6.9 9.0 9.8 12.2 13.6 7.4 6.6 3.0 0.0 8.8 14.1 44.0 4.9 6.6 8.7 11.6 9.7 8.2 13.5 10.2 4.2 1.4 3.3 11.4 19.3 25.0 15.1 26.1 25.3 5.5 12.7 12.6 11.7 12.8 11.0 4.4 11.0 13.9 1.3 2.7 3.2 15-HETE 68.1 99.1 66.6 47.7 195.6 74.0 69.6 56.5 43.9 407.3 243.7 400.6 175.0 305.9 207.4 297.5 96.2 186.7 87.2 108.6 81.7 51.8 562.8 87.7 98.0 101.9 95.8 21.4 37.8 75.0 156.3 11.0 18.4 24.6 22.6 53.6 75.1 10.6 9.3 397.7 370.3 142.1 282.8 284.1 313.4 389.3 397.6 298.4 417.5 299.6 282.3 34.8 56.3 73.5 185.6 33.9 109.0 30.1 41.7 100.9 67.8 69.8 18.9 177.9 228.0 1193.6 168.3 198.6 293.2 342.6 322.4 217.1 264.9 306.5 119.2 807.9 195.9 126.0 363.8 427.2 1205.8 1326.5 189.3 240.4 72.2 7.6 31.0 34.5 48.7 24.1 27.0 109.4 26.4 75.3 45.8 219.1 158.1 33.4 32.6 27.0 8.5 11.8 191.9 198.7 410.4 164.4 148.4 175.9 429.3 343.5 383.7 222.3 218.1 81.2 32.3 83.8 38.5 63.6 52.0 57.9 380.9 33.0 49.4 99.8 16.5 23.4 29.3 50.8 33.1 157.5 51.2 43.2 19.3 9.1 22.6 167.1 233.4 245.6 287.3 173.5 184.8 47.9 208.7 168.8 50.7 61.5 44.7 141.1 50.7 67.1 27.9 29.7 20.6 12-HETE 15.3 12.2 9.4 8.2 11.8 10.8 9.7 6.6 7.3 79.9 27.2 61.7 30.1 22.5 28.1 35.6 8.1 17.4 16.3 11.5 10.7 9.6 74.3 9.8 8.6 5.7 13.5 9.4 8.9 9.6 11.0 5.4 5.8 9.0 6.1 6.3 7.9 3.7 3.7 68.2 62.3 21.1 27.8 29.1 35.8 84.9 68.9 36.6 52.4 27.6 19.2 5.0 8.2 9.1 10.6 4.3 6.7 6.9 9.5 14.1 6.9 14.1 3.3 66.7 51.0 362.2 48.9 65.5 87.5 92.9 114.2 84.7 69.5 69.1 26.2 218.2 40.9 37.9 144.1 137.0 359.6 374.4 65.0 67.5 6.5 2.5 10.9 14.5 9.7 8.8 23.6 34.9 22.3 33.3 22.3 58.6 47.9 17.5 16.2 11.8 7.4 8.0 53.1 47.9 122.4 58.7 49.2 57.5 197.4 117.7 147.2 84.0 177.0 14.7 12.3 25.5 13.2 15.7 11.4 13.2 306.8 7.9 12.5 28.0 4.6 6.0 59.9 82.7 30.5 36.3 117.2 34.7 40.8 15.3 38.8 39.5 72.1 58.9 41.0 58.6 54.0 61.3 38.2 28.4 64.9 63.1 17.6 15.8 14.8 15.5 21.3 11.0 9.6 5-HEPE 43.7 51.4 45.6 27.1 37.5 45.1 28.1 30.6 28.0 70.2 53.1 63.7 44.1 43.8 55.4 49.3 28.5 52.4 47.7 63.8 46.5 27.7 53.2 55.9 36.6 23.6 31.5 39.7 37.9 30.8 20.8 17.2 25.4 51.4 45.5 60.6 51.6 16.2 15.0 180.6 85.4 51.1 44.4 101.6 48.7 194.9 166.1 90.9 91.0 131.4 118.3 32.8 36.7 31.6 24.1 16.2 28.5 50.2 44.7 56.4 36.1 17.2 15.0 17.4 65.2 39.1 61.6 7.0 12.1 21.6 36.2 9.8 77.0 82.7 95.2 102.0 51.0 39.9 211.6 93.9 30.8 20.5 55.9 23.5 52.5 6.6 16.3 19.7 32.0 8.0 19.9 17.8 32.0 33.0 5.2 18.4 26.0 18.3 46.0 24.9 8.0 7.1 130.9 127.9 104.9 62.0 21.8 28.7 158.8 199.7 122.1 94.4 24.2 33.3 26.8 27.2 31.7 18.1 10.9 8.1 40.8 19.7 51.1 94.0 11.8 13.2 16.4 24.4 20.5 89.7 26.3 27.8 11.2 3.8 5.6 84.8 103.8 126.5 115.1 68.1 61.5 17.3 62.3 56.5 31.6 24.4 23.0 113.0 26.3 40.5 8.5 10.7 7.2 5-HETE 46.3 50.4 41.5 26.7 46.8 31.5 18.5 23.5 18.6 284.1 112.2 282.8 58.6 70.8 85.6 128.2 21.3 54.8 30.5 51.4 48.6 25.8 188.5 28.8 29.4 19.2 34.1 13.2 33.5 29.0 30.2 6.3 7.5 16.4 20.7 39.9 37.9 5.3 4.4 391.1 357.0 65.8 66.5 167.3 140.5 354.5 322.1 110.1 118.8 153.2 115.7 16.9 37.2 32.8 33.5 11.1 28.6 22.3 23.3 65.2 30.4 31.6 5.9 968.3 508.2 5129.9 544.9 741.4 628.3 540.0 1884.7 1280.8 713.9 342.3 66.4 3303.6 242.2 561.3 1252.7 1978.2 3894.7 1660.8 670.0 568.8 36.4 4.6 50.2 89.8 28.7 64.8 24.8 60.7 97.2 127.5 76.6 311.2 129.5 80.1 58.2 24.6 8.6 3.9 352.6 259.0 471.4 467.4 356.7 271.0 1349.6 1241.8 564.0 299.7 862.6 34.2 15.9 33.9 40.4 31.1 25.0 20.1 13.4 22.7 23.3 18.1 8.0 6.3 15.8 21.4 10.7 89.8 21.3 16.4 17.6 10.6 22.6 139.5 182.8 196.8 123.0 59.2 64.6 34.8 76.6 58.3 34.5 34.1 15.9 84.0 14.2 22.6 63.7 9.3 17.6 epi-LTB4 0.8 1.1 0.6 0.1 0.4 0.0 0.1 2.3 0.1 37.9 18.5 43.4 2.6 1.0 6.9 15.1 1.3 5.3 0.2 5.5 4.7 0.2 11.9 1.1 3.4 1.4 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 87.2 146.4 8.4 5.9 41.3 21.4 89.9 92.8 8.9 12.1 26.1 17.9 3.6 6.2 0.0 0.0 4.5 9.4 0.0 0.0 0.0 0.0 0.0 0.0 267.8 130.4 984.4 168.3 155.9 75.3 34.6 443.8 259.2 145.2 103.0 11.9 1434.4 58.6 174.0 356.7 584.3 470.2 123.4 213.9 127.3 0.0 4.1 10.8 35.3 5.4 19.2 4.3 4.3 13.9 15.8 10.0 34.4 12.2 10.4 6.6 3.9 0.5 0.0 57.4 33.0 41.9 63.5 49.2 47.7 207.8 215.9 125.3 50.4 106.8 5.2 5.4 4.2 4.8 4.3 6.4 3.9 0.0 5.9 5.6 4.6 6.6 3.2 7.0 6.0 2.0 4.5 9.4 2.7 2.6 4.8 7.3 13.9 13.7 15.8 5.1 10.5 10.0 11.9 9.9 5.9 8.5 11.6 5.6 1.9 3.7 6.0 4.9 3.2 3.0 LTB4 1.8 1.8 1.9 1.4 0.4 1.0 1.1 2.4 0.9 16.8 7.2 21.3 1.7 0.9 0.4 3.5 0.6 0.4 3.5 3.2 3.8 1.1 4.2 2.3 4.2 3.5 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.1 74.4 0.5 0.2 9.3 1.7 51.2 58.5 2.6 3.9 3.2 3.2 3.1 2.9 0.0 0.0 3.4 5.8 0.0 0.0 0.0 0.0 0.0 0.0 141.5 91.6 777.2 107.8 115.4 84.8 73.6 226.7 137.7 99.0 46.9 6.7 691.9 62.9 82.0 183.9 317.5 804.4 432.8 160.9 118.8 2.1 1.1 5.8 21.7 5.5 11.9 3.1 4.9 1.9 2.2 1.5 13.8 5.8 2.4 2.5 1.4 0.2 0.0 11.4 11.1 15.7 10.1 6.4 7.4 27.7 25.9 15.5 19.4 66.5 1.2 3.5 3.3 1.6 1.0 1.9 0.7 0.0 2.5 2.9 1.3 3.3 0.9 2.5 2.9 1.9 2.3 7.9 2.0 1.2 8.9 2.0 3.5 5.9 7.3 4.7 6.0 3.1 3.4 4.1 6.6 9.1 13.1 5.1 0.6 1.2 2.9 2.7 0.6 1.3 7-HDHA* 7.0 8.7 8.9 3.8 4.4 6.8 3.9 3.7 3.3 17.8 8.9 13.9 8.0 5.7 9.2 11.3 3.9 5.9 8.9 9.6 4.7 4.8 5.7 5.0 4.6 3.8 4.9 4.7 4.3 4.4 4.1 4.6 3.0 7.7 5.1 5.1 7.0 3.5 3.4 22.4 12.5 7.6 5.0 16.3 8.0 25.0 15.6 12.0 11.2 14.2 10.8 3.8 5.5 5.6 3.2 3.8 3.1 5.0 5.8 7.0 5.2 6.6 3.4 4.1 7.1 6.0 7.2 1.7 1.5 5.5 6.8 2.8 6.1 13.5 8.8 6.6 5.7 6.7 19.3 9.4 3.1 4.5 5.7 4.4 4.7 1.1 4.4 6.7 4.4 2.2 6.2 5.3 5.4 1.6 3.0 1.9 8.4 7.9 7.9 6.9 2.7 1.6 19.3 20.6 15.7 14.1 6.5 9.0 19.2 25.4 14.0 12.2 8.0 5.5 6.1 4.9 6.7 3.8 3.6 3.0 0.0 7.8 6.8 0.0 3.5 1.5 10.7 9.4 9.8 15.6 9.3 10.0 4.1 3.1 4.5 22.4 24.4 26.2 16.9 19.1 19.0 10.0 14.1 16.8 15.4 12.0 16.3 17.1 9.1 10.3 4.3 4.6 4.9 4-HDHA* 10.6 11.2 8.7 4.4 9.5 5.1 5.4 7.0 4.3 52.6 20.1 39.3 11.5 13.5 22.3 29.7 4.2 13.9 5.6 14.2 13.0 5.3 23.1 5.5 5.3 2.9 5.9 3.4 7.1 7.1 6.7 1.9 1.9 4.0 4.0 5.6 7.1 1.6 0.9 37.0 19.0 13.7 11.7 27.4 16.6 32.8 28.6 19.4 23.7 22.1 16.7 4.1 6.5 7.5 6.9 0.8 4.8 4.0 5.1 8.5 4.0 6.3 3.5 1.1 8.0 2.2 6.5 0.4 0.8 1.7 2.8 0.8 15.8 41.8 9.1 13.9 5.3 5.4 35.5 8.6 2.4 1.5 6.7 0.7 4.9 0.7 4.9 1.6 3.3 1.0 3.3 3.0 1.7 1.1 2.6 9.0 4.6 4.3 10.7 5.8 1.7 2.1 36.6 37.3 18.4 21.0 4.8 21.8 32.6 49.1 16.3 13.7 9.4 7.4 3.1 3.5 1.5 1.3 1.1 1.0 7.4 5.4 2.8 0.2 1.6 0.7 5.9 5.8 3.9 21.3 2.8 7.1 4.7 0.6 1.1 42.5 55.6 65.6 32.8 16.0 19.3 9.5 29.5 22.4 8.2 5.9 3.4 22.2 4.3 4.4 10.6 0.5 2.2 7-HDPA* 30.9 47.9 33.9 23.7 50.4 21.2 12.4 57.3 12.6 176.9 89.2 145.8 45.8 54.9 78.1 92.3 14.1 37.6 19.3 48.9 34.9 20.8 57.2 30.1 16.7 14.3 9.0 6.4 30.2 24.1 28.6 8.7 7.3 8.5 13.5 26.1 25.4 5.8 2.1 145.5 84.3 58.4 58.6 109.1 69.4 131.1 103.1 84.6 97.7 82.5 60.9 11.2 28.3 26.1 28.1 6.0 14.6 15.2 13.3 30.3 23.0 13.3 4.2 2.5 24.1 5.9 32.5 0.0 3.7 3.7 9.5 1.0 54.3 141.4 48.1 73.0 19.5 19.7 146.8 40.3 11.4 3.6 16.5 6.0 27.9 0.0 9.1 4.1 8.1 1.9 4.1 2.3 3.3 2.8 0.4 10.2 8.4 5.6 8.8 7.1 1.8 0.1 110.1 75.1 86.1 32.2 10.8 16.1 86.0 128.1 42.4 44.7 12.3 16.0 7.9 0.0 4.0 6.0 4.1 2.8 0.0 7.0 8.7 0.0 5.2 2.5 10.7 12.2 12.3 75.8 12.8 29.5 10.9 7.7 8.3 105.3 106.3 132.0 134.2 61.9 57.1 25.2 72.5 49.7 19.1 13.5 6.0 91.0 12.5 14.7 2.7 0.0 7.1 18-HEPE 104.8 105.5 83.6 66.2 49.3 86.5 121.8 114.0 109.7 108.4 86.1 82.3 89.0 51.9 83.9 188.7 99.0 185.7 110.9 101.8 82.5 66.6 84.4 97.5 158.0 101.0 151.7 99.6 66.1 20.9 25.9 68.2 76.4 129.1 73.8 50.6 42.3 63.5 57.5 110.4 71.8 34.4 39.8 138.9 112.6 141.5 102.4 77.8 78.4 182.5 190.4 103.9 60.0 25.1 29.0 59.4 92.7 107.6 88.0 55.5 33.7 61.6 37.8 71.3 87.6 91.4 72.2 21.2 57.0 87.3 109.0 15.2 78.4 64.2 165.4 116.4 99.6 90.8 170.9 178.1 51.6 72.0 73.8 79.4 80.2 19.8 52.9 92.0 103.6 20.0 90.9 88.0 82.9 104.7 21.0 27.7 117.8 94.3 116.8 69.9 30.8 24.9 119.4 168.8 152.2 105.4 55.1 62.7 140.3 168.6 222.0 165.5 49.4 98.0 115.8 137.6 112.8 59.3 34.7 31.0 93.9 98.2 147.3 397.2 33.1 51.8 63.1 117.7 123.6 44.2 64.4 108.3 16.6 17.5 12.2 91.0 153.9 170.1 56.9 137.5 156.2 24.6 92.6 110.5 99.7 100.8 151.4 62.7 94.8 157.4 6.7 27.9 34.2 5,15-diHETE 101.4 50.5 43.2 46.4 11.3 35.7 20.6 86.8 39.7 22.8 16.0 34.5 45.3 29.1 9.0 21.6 11.6 29.2 22.9 19.5 36.7 15.9 60.7 43.8 48.8 50.1 42.9 12.1 8.9 9.0 20.3 5.9 26.6 24.1 12.6 15.5 11.6 13.6 15.3 15.3 19.0 14.3 13.5 36.5 24.9 22.0 20.4 20.6 13.0 14.8 19.5 20.5 13.6 24.5 41.0 12.4 18.9 29.0 48.6 56.4 26.3 41.9 34.2 102.5 69.5 418.5 91.2 98.1 108.7 116.8 162.3 117.7 71.0 32.0 51.9 336.5 54.5 72.2 119.6 187.9 423.6 207.9 114.9 94.2 23.3 33.0 31.2 64.3 46.6 67.9 22.0 16.0 18.3 15.4 23.2 50.1 25.3 26.0 18.7 17.5 13.1 14.9 19.6 14.2 23.6 19.8 19.0 18.9 22.4 24.9 18.0 29.1 37.6 31.3 14.0 11.7 14.7 14.5 5.7 17.8 186.6 12.3 10.4 13.7 14.5 7.2 13.1 0.0 10.1 6.0 0.1 6.0 8.8 9.7 7.6 21.3 25.0 2.8 8.9 0.3 0.0 15.6 12.8 0.0 4.9 9.1 4.2 1.4 1.7 4.0 1.6 2.4 4.2 11-HEPE 16.5 18.3 15.0 11.3 51.5 25.7 15.0 12.5 15.9 33.7 25.2 29.1 25.7 52.8 34.4 34.0 16.8 32.0 20.8 21.3 14.3 12.0 63.5 28.6 21.8 20.2 21.8 12.2 10.0 14.0 22.1 6.5 15.8 17.1 9.5 31.0 33.8 6.2 6.5 43.9 24.5 22.4 36.6 41.0 30.4 48.5 45.2 57.0 72.5 42.4 41.1 8.3 12.9 18.2 29.9 8.4 21.9 14.7 14.9 31.7 26.1 5.9 6.1 7.3 14.0 13.6 32.0 4.1 7.5 8.6 26.5 2.8 16.0 25.9 35.5 72.1 19.5 17.1 36.6 50.2 12.1 7.7 11.2 13.1 31.1 4.9 6.1 8.4 29.3 4.3 9.7 10.0 13.0 17.1 2.9 5.1 11.6 10.3 11.4 11.2 4.6 3.7 34.5 40.9 46.9 35.5 12.6 19.3 35.4 53.5 41.3 43.5 16.0 23.7 14.5 16.2 17.6 12.7 6.7 5.1 0.0 11.7 16.0 74.5 5.0 7.4 7.3 10.8 12.0 119.8 18.1 23.3 7.2 5.7 2.3 21.8 32.9 35.4 131.0 58.7 48.1 8.2 32.6 30.3 11.2 13.9 15.7 134.4 26.1 37.5 4.2 6.8 7.7 11-HETE 40.2 53.1 32.4 34.3 356.4 62.7 23.6 533.6 29.1 293.9 166.4 284.2 146.5 474.1 274.8 279.8 78.9 169.5 37.7 65.6 47.0 37.9 370.9 92.0 84.1 88.4 91.5 11.1 26.1 117.4 291.4 8.8 16.0 13.3 13.7 87.5 131.8 6.2 5.6 320.4 302.3 222.8 514.3 310.9 265.9 325.0 322.9 414.4 654.6 321.1 288.0 18.4 34.8 145.4 385.7 26.4 88.2 19.6 29.0 115.0 118.7 26.4 21.5 30.8 36.1 190.6 113.4 28.4 39.9 36.7 72.6 39.2 96.0 189.9 138.4 738.7 67.7 62.7 211.6 261.1 218.0 177.1 41.8 41.8 147.9 4.2 24.8 11.6 48.3 9.5 8.6 23.8 8.4 17.4 8.4 36.1 40.5 10.1 15.2 9.0 4.4 2.3 119.2 133.1 257.3 143.9 65.7 97.9 235.2 194.7 277.1 178.8 129.6 60.8 10.2 20.3 24.0 21.8 10.8 11.9 10.9 9.6 30.5 43.8 10.4 7.6 9.1 20.1 12.4 549.1 21.4 22.7 9.3 8.9 11.5 152.3 173.8 198.3 814.3 218.0 210.6 37.9 235.7 183.4 24.9 17.4 14.3 475.9 46.1 63.1 21.8 13.7 15.2 PGD2 25.4 59.2 33.7 6.7 91.5 21.7 18.6 62.1 24.1 75.0 165.5 108.4 24.5 112.8 61.5 71.6 66.3 68.8 42.5 133.8 84.8 8.1 90.8 21.0 89.1 98.6 77.3 9.2 29.4 16.7 39.8 8.7 17.5 9.8 16.2 23.9 25.2 6.6 5.3 77.5 148.2 24.2 59.1 84.7 70.0 58.7 79.9 66.1 82.5 60.9 84.9 21.6 63.6 18.1 44.0 37.7 122.0 20.8 45.5 37.1 39.4 35.0 32.8 35.9 69.0 50.0 94.2 23.9 109.4 66.9 66.6 22.3 109.4 242.9 131.8 331.9 50.0 78.3 68.0 113.5 74.9 46.6 83.8 38.0 122.5 190.4 98.3 24.7 72.5 15.7 32.9 28.8 19.6 20.1 14.1 37.6 43.5 47.6 25.1 29.5 17.6 14.6 88.3 109.0 113.5 63.5 80.7 105.9 100.4 94.5 88.3 81.1 93.2 118.0 28.9 33.1 16.7 44.9 20.6 16.3 0.2 44.5 26.7 54.5 21.2 26.7 491.9 371.4 336.8 2087.3 346.8 186.7 177.7 380.8 467.6 649.4 1080.5 424.1 922.7 282.6 567.4 175.4 461.4 897.7 534.2 374.0 59.7 747.7 200.6 248.3 50.4 68.7 93.2 PGE2 32.3 63.3 35.0 20.3 249.1 36.5 33.9 52.2 35.5 192.4 162.3 237.0 98.2 322.2 178.3 161.3 61.4 101.0 26.5 52.4 46.0 28.7 218.5 67.3 66.4 59.4 48.5 8.4 27.0 67.5 161.5 13.7 10.1 13.3 14.4 58.1 71.8 6.9 6.6 133.2 164.5 148.6 234.8 97.5 108.1 137.1 144.0 176.5 212.4 96.6 112.0 17.9 25.5 97.5 181.7 25.0 64.2 11.2 45.4 102.5 119.4 31.5 24.5 15.9 57.2 41.5 122.3 27.7 107.5 62.8 41.4 10.4 77.9 316.0 133.5 471.7 59.3 71.2 177.8 144.6 120.0 49.7 32.5 34.5 173.2 212.5 45.1 14.9 57.1 14.2 8.5 6.5 5.0 8.4 8.5 10.9 15.4 10.7 11.4 6.2 11.1 6.4 80.7 71.4 62.2 56.0 47.8 57.3 82.4 91.9 54.0 59.0 60.7 68.5 8.0 7.4 10.1 12.9 14.0 9.3 49.9 8.5 19.3 14.1 15.4 10.5 67.1 19.1 79.1 313.6 111.1 10.8 16.1 35.5 212.7 122.6 250.1 160.3 374.7 223.5 78.2 68.9 85.2 131.3 168.9 147.8 12.5 185.2 21.7 28.0 10.5 15.1 30.7 15-Keto-PGE2 6.1 5.9 5.0 2.3 7.9 3.4 3.7 2.3 2.6 34.8 11.1 30.6 17.2 13.8 13.1 25.9 7.2 11.9 3.8 6.9 6.4 4.0 13.0 4.9 8.1 7.4 5.9 1.6 4.5 3.9 6.2 1.5 1.8 1.2 1.8 2.5 4.3 1.5 0.9 32.1 23.6 12.8 15.6 25.1 15.9 21.5 23.9 15.3 29.0 14.5 15.2 3.3 4.9 4.1 5.2 4.1 6.6 3.0 9.9 7.4 7.1 8.2 8.4 3.9 6.3 8.5 6.4 2.2 6.3 3.1 5.3 2.7 7.0 34.2 5.9 15.6 6.8 7.2 36.7 9.2 16.0 11.7 5.5 3.6 4.1 3.6 2.9 1.8 4.7 2.5 0.6 2.0 1.1 1.1 2.3 2.2 1.5 1.4 0.0 2.9 0.6 0.1 9.8 7.5 9.8 8.0 9.0 11.8 15.4 18.4 16.6 7.5 13.3 8.3 1.3 2.3 1.2 2.7 3.6 4.2 0.0 2.0 3.5 2.8 2.4 2.4 57.0 21.4 0.0 0.0 36.3 0.0 63.4 15.0 0.0 0.0 38.4 33.1 0.0 7.3 0.3 18.1 32.8 122.5 45.1 39.3 1.7 7.1 1.5 0.9 2.4 1.3 1.2 PGF2alpha 22.6 23.3 15.7 9.8 89.9 21.5 19.6 46.5 22.4 98.5 76.2 94.8 37.3 116.3 79.1 105.0 49.8 64.8 20.8 30.8 26.0 11.9 62.0 25.9 49.2 33.7 33.6 7.2 10.7 22.1 42.4 9.4 9.4 8.5 8.3 22.7 34.1 4.9 4.9 111.1 67.2 40.0 57.6 134.0 66.5 84.9 90.4 75.3 117.4 115.8 116.5 10.8 14.6 29.2 55.2 27.2 41.4 12.2 21.3 46.9 48.4 23.2 22.7 16.6 17.5 17.5 61.8 13.7 15.8 25.5 51.0 19.1 49.6 92.8 91.1 200.5 120.2 55.8 172.6 142.2 68.2 21.7 18.4 22.2 76.4 22.5 23.5 26.7 71.7 26.3 12.8 15.5 15.2 14.4 16.0 20.0 15.6 15.7 15.8 13.2 19.9 16.2 66.8 66.7 67.4 62.2 70.1 86.2 66.3 64.9 47.6 50.0 85.8 103.5 18.6 13.1 18.3 16.9 22.7 18.5 0.0 17.4 16.0 16.4 20.5 20.1 20.6 22.3 50.9 185.8 6.3 32.2 40.9 60.7 29.2 134.2 126.2 98.7 379.4 16.0 79.5 131.6 119.3 265.0 38.1 26.6 5.5 96.9 15.3 19.8 5.8 8.2 8.7 TXB2 103.0 190.0 97.3 100.7 1601.6 255.6 199.9 463.8 235.6 1942.2 1147.5 1897.0 682.9 2540.3 1581.5 2353.1 992.7 1518.1 111.8 260.6 188.6 152.9 1457.6 441.4 665.1 785.3 672.5 20.6 71.8 286.1 955.2 56.5 100.0 36.1 49.4 316.4 481.5 55.5 57.7 2330.4 1742.2 768.6 1748.6 2993.0 1945.3 1958.8 2026.0 2055.2 2735.0 2688.1 2740.8 63.1 104.5 408.8 1329.0 226.8 622.8 68.6 194.8 621.4 769.0 232.6 285.2 19.1 34.8 74.8 812.8 19.9 62.4 16.9 232.3 34.5 771.5 2437.6 1595.9 5542.4 1768.1 1229.5 2481.7 1969.6 956.3 37.6 90.3 175.2 1283.5 84.5 295.5 44.3 558.3 122.0 12.9 9.9 37.8 31.3 39.8 42.6 18.2 27.6 52.4 32.1 33.9 34.0 762.6 785.2 1443.1 1092.7 616.3 977.3 732.7 965.2 991.1 1130.0 787.9 960.9 25.8 20.8 101.7 121.8 72.3 55.8 0.0 23.6 148.0 126.1 88.6 73.3 164.9 69.1 148.1 1327.2 261.3 268.8 138.8 115.0 200.3 916.2 746.2 1047.9 2015.8 1113.0 619.0 979.5 1555.0 2693.1 156.8 233.8 34.1 1295.5 274.5 276.4 121.0 137.7 138.8 PGE1 1.8 1.1 1.7 2.5 13.6 3.0 3.2 2.9 2.2 8.9 4.9 8.5 7.1 14.3 9.6 8.2 3.0 4.0 1.4 2.2 2.3 1.3 10.3 3.8 4.0 2.6 3.2 1.4 0.5 3.8 6.3 2.1 0.2 1.2 1.1 5.2 5.8 0.6 0.7 10.6 4.6 8.8 10.4 11.8 4.9 8.9 5.9 11.5 28.6 8.4 14.4 1.5 1.0 7.6 10.7 1.7 1.9 1.6 2.5 6.8 6.3 1.7 0.8 1.1 4.0 5.0 14.0 2.1 3.6 3.9 8.6 2.5 8.4 14.8 10.3 29.7 9.6 6.1 17.4 21.2 10.5 2.8 0.6 2.3 14.0 4.9 4.6 2.1 10.9 3.1 0.6 0.9 1.4 1.7 1.1 3.1 0.9 1.4 2.0 2.0 1.2 1.5 8.8 8.1 8.0 8.7 6.2 9.5 9.6 9.9 5.8 8.0 9.0 10.9 2.1 2.1 0.6 1.8 1.8 0.9 0.0 2.4 2.1 1.6 1.7 1.7 44.4 21.7 7.9 87.2 9.6 21.1 21.8 6.5 8.9 49.2 42.6 51.7 46.2 34.3 30.1 69.2 59.0 31.0 11.5 8.2 2.8 20.1 1.8 4.3 4.0 3.6 4.3 Arachidonic acid 176389.8 179023.0 112214.9 52065.3 226860.0 54109.1 69380.6 79137.2 52594.9 3767354.0 957688.3 2730742.1 1142456.7 860488.7 1161819.0 1895716.9 228136.1 550378.0 153492.5 148633.2 199509.0 89107.6 403710.8 97909.5 262796.2 95158.4 152018.5 23742.0 99315.4 115425.2 221339.5 25587.4 33339.7 30034.6 42688.2 46935.4 55274.0 16652.0 14573.6 2848301.2 2085762.6 748696.2 947155.1 1686043.1 1478605.2 2841795.4 2421676.8 1309818.5 1197527.6 1729654.8 1186925.7 81068.5 232948.0 169750.8 349967.3 114946.9 358848.5 61119.3 94793.3 62326.6 55526.1 88283.2 58693.3 73632.1 113108.5 326259.8 74598.8 92712.5 123225.9 115486.2 115244.6 103253.5 926697.2 3957001.2 496420.6 1098547.9 340858.8 316627.2 2818744.5 412411.0 518426.2 526915.3 182110.8 137633.2 68604.0 20366.0 138033.7 27362.7 29034.7 54209.6 26133.6 52417.6 27581.7 72003.0 89259.6 161684.2 132183.0 32489.2 23743.2 13384.7 26447.2 23911.7 2257376.2 1405502.0 1539090.5 557606.2 397278.9 702398.6 2265689.7 2849694.2 1458998.4 478455.4 405425.2 298356.3 37028.6 62932.9 51664.3 62913.9 108814.6 84150.5 311204.5 39189.0 107802.2 334155.1 91998.1 76207.1 57951.8 67520.5 38779.9 350632.8 50161.4 57052.1 60329.5 66523.7 53667.1 1761174.5 2237812.7 2569979.0 1189748.0 639419.3 604573.2 490322.8 1454822.4 1423316.1 149046.2 68654.4 85806.5 259663.8 58456.4 94639.0 156141.2 118127.6 144332.0 EPA 6711.0 7864.5 5520.8 1975.6 8333.7 2489.4 3295.7 2074.3 2418.8 64716.7 19334.5 45159.1 29827.1 20428.7 24850.8 35756.7 4966.2 14210.2 7023.9 6284.4 8137.0 2263.2 8007.5 2952.3 7186.2 2113.2 4166.7 1675.6 5192.3 4587.9 6418.6 1037.2 1748.0 1877.9 2612.4 3014.9 3198.5 796.3 637.7 89582.8 33884.0 26300.0 21515.0 42128.3 33117.6 83774.8 69392.3 41244.7 31271.0 50020.8 37483.8 2799.9 6084.2 5890.6 8713.8 2534.5 8373.7 3111.5 3384.6 2137.5 2249.0 1618.1 1089.2 287.1 2187.1 225.4 1136.7 175.8 519.7 266.9 268.2 228.6 28315.9 68827.3 18246.9 20914.2 9363.7 6262.3 107188.3 9192.4 2909.2 557.6 2529.8 385.2 1826.5 517.8 2118.1 569.6 564.4 753.6 892.9 669.0 327.8 689.0 923.3 1055.5 1587.7 520.0 561.5 287.6 755.3 809.6 76270.9 52627.6 30080.1 10657.3 8739.5 13799.7 72644.6 117262.5 28506.3 14199.5 8410.6 12727.0 2132.6 1634.5 1576.8 1103.8 2581.3 2278.0 8428.3 1431.3 3140.6 7102.3 3364.1 3808.6 1277.1 1604.4 1384.0 14962.3 825.6 1109.3 1381.4 1780.1 1321.5 28307.5 67324.2 79861.4 34973.5 13046.7 12301.1 5247.8 44888.3 40305.7 3565.5 1703.0 2415.8 10090.1 1210.4 2162.2 1046.5 3537.3 3861.2 DHA 117517.1 111501.2 82364.7 38549.4 112699.8 40733.9 44000.3 30801.0 33598.8 1666684.9 414494.4 1263354.9 566118.4 341595.5 612765.0 909166.4 107511.9 326912.6 76298.8 91239.3 119920.1 44370.0 133177.6 51929.7 88057.4 22208.7 40861.7 25901.4 72502.7 90516.0 118694.7 27274.1 23870.2 30447.6 44951.4 64154.9 67022.2 15640.0 14089.9 1415176.1 743075.0 546372.3 504048.2 930235.0 607570.1 1426572.0 1205569.5 852337.2 723186.6 963399.3 652578.8 39884.8 80810.0 119340.0 179269.4 36131.3 77708.4 34912.8 55759.9 43624.7 38669.5 33178.3 16470.8 7137.2 46999.6 7507.1 41910.4 5615.9 16446.5 9845.6 11133.6 9398.0 484365.9 1768202.8 316251.0 581596.4 178423.1 167960.0 1551420.0 246463.0 119137.7 10934.3 56070.3 9053.7 53657.5 11001.4 56376.7 14562.8 15911.3 24710.3 17573.7 12312.4 7636.5 14321.8 18475.5 19986.8 30466.1 14274.9 14022.7 25694.0 16152.6 14409.7 1248608.4 899391.9 700039.1 289204.5 195059.8 299896.8 1327758.6 1691826.9 553773.3 267892.2 235831.0 208803.6 23261.0 23530.3 21482.7 16964.4 40677.4 30416.8 157711.5 21434.0 40937.8 201490.2 49104.5 39569.0 42228.0 31359.3 26948.5 405354.4 23073.2 32127.3 28513.0 32641.9 25466.8 1236711.4 1576532.6 1644325.8 1078790.7 500778.4 478015.7 414369.3 1050030.7 1046378.0 85538.6 46040.9 50003.7 309401.5 29631.2 42028.8 64046.6 58383.0 62881.9 DPA 3621.2 2794.7 2102.5 961.8 2811.9 858.8 1095.2 984.1 926.8 69097.8 14737.0 48893.9 17657.8 11900.4 22920.0 38597.0 3751.3 9144.6 2443.3 2308.5 3675.5 1290.1 3740.7 1444.1 2297.1 725.2 1137.7 619.7 1758.4 1424.4 2366.6 554.2 499.0 722.6 1039.5 1200.5 1212.6 388.0 305.7 58552.5 22049.4 14136.0 14581.8 29981.4 14929.2 31814.6 27254.9 22534.4 21244.1 27701.3 12295.3 925.2 1877.4 2348.9 4707.2 831.8 1711.9 1069.5 1735.2 855.4 898.8 724.1 479.6 155.8 756.7 163.3 904.1 130.0 381.7 190.4 109.0 219.4 10596.0 64357.8 8019.6 15900.1 3898.2 3703.5 52435.9 6214.7 3069.3 262.5 1203.9 210.0 1181.0 238.3 1397.9 377.9 365.6 743.1 386.4 226.0 159.4 210.4 496.9 546.0 765.2 308.6 335.0 186.5 522.7 308.2 48730.9 23085.4 26682.6 8563.0 4773.7 6217.2 35590.0 39696.5 11844.1 6681.4 5939.8 4978.3 430.2 297.4 430.0 382.5 955.9 770.1 3403.3 592.9 1005.2 3390.9 1021.7 744.5 1256.3 753.6 655.2 6902.7 511.4 678.4 498.6 770.4 481.5 46102.1 58727.6 66042.1 27730.6 15002.3 15978.9 12513.6 32966.6 30512.0 1965.7 1047.5 1673.3 6032.1 656.4 943.9 1124.6 1532.3 1691.3 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name metaboite name (ID in Analyst file) formula exactmass super_class main_class sub_class 17S-HDHA 17-HDHA C22H32O3 344.2351 Fatty Acyls Docosanoids Docosanoids 14S-HDHA 14-HDHA C22H32O3 344.2351 Fatty Acyls Docosanoids Docosanoids 17-HDPA* 17-HDPA C22H34O3 346.2508 Fatty Acyls Docosanoids Docosanoids 14-HDPA* 14-HDPA C22H34O3 346.2508 Fatty Acyls Docosanoids Docosanoids 15-HEPE 15-HEPE C20H30O3 318.2195 Fatty Acyls Eicosanoids HEPE 12-HEPE 12-HEPE C20H30O3 318.2195 Fatty Acyls Eicosanoids HEPE 15-HETE 15-HETE C20H32O3 320.2351 Fatty Acyls Eicosanoids HETE 12-HETE 12-HETE C20H32O3 320.2351 Fatty Acyls Eicosanoids HETE 5-HEPE 5-HEPE C20H30O3 318.2195 Fatty Acyls Eicosanoids HEPE 5-HETE 5-HETE C20H32O3 320.2351 Fatty Acyls Eicosanoids HETE epi-LTB4 LTB4 isomers C20H32O4 336.2301 Fatty Acyls Eicosanoids Leukotrienes LTB4 LTB4 C20H32O4 336.2301 Fatty Acyls Eicosanoids Leukotrienes 7-HDHA* 7-HDHA C22H32O3 344.2351 Fatty Acyls Docosanoids Docosanoids 4-HDHA* 4-HDHA C22H32O3 344.2351 Fatty Acyls Docosanoids Docosanoids 7-HDPA* 7-HDPA C22H34O3 346.2508 Fatty Acyls Docosanoids Docosanoids 18-HEPE 18-HEPE C20H30O3 318.2195 Fatty Acyls Eicosanoids HEPE 5,15-diHETE 5,15-diHETE C20H32O4 336.2301 Fatty Acyls Eicosanoids HETE 11-HEPE 11-HEPE C20H30O3 318.2195 Fatty Acyls Eicosanoids HEPE 11-HETE 11-HETE C20H32O3 320.2351 Fatty Acyls Eicosanoids HETE PGD2 PGD2 C20H32O5 352.225 Fatty Acyls Eicosanoids Prostaglandins PGE2 PGE2 C20H32O5 352.225 Fatty Acyls Eicosanoids Prostaglandins 15-Keto-PGE2 15-ketoPGE2 C20H30O5 350.2093 Fatty Acyls Eicosanoids Prostaglandins PGF2alpha PGF2a C20H34O5 354.2406 Fatty Acyls Eicosanoids Prostaglandins TXB2 TXB2 C20H34O6 370.2355 Fatty Acyls Eicosanoids Thromboxanes PGE1 PGE1/PGD1 C20H34O5 354.2406 Fatty Acyls Eicosanoids Prostaglandins Arachidonic acid AA C20H32O2 304.2402 Fatty Acyls Fatty acids Unsaturated FA EPA EPA C20H30O2 302.2246 Fatty Acyls Fatty acids Unsaturated FA DHA DHA C22H32O2 328.2402 Fatty Acyls Fatty acids Unsaturated FA DPA DPA C22H34O2 330.2559 Fatty Acyls Fatty acids Unsaturated FA METABOLITES_END #END