#METABOLOMICS WORKBENCH cararolopes_20250320_074341 DATATRACK_ID:5753 STUDY_ID:ST003887 ANALYSIS_ID:AN006385 PROJECT_ID:PR002436 VERSION 1 CREATED_ON May 1, 2025, 11:28 am #PROJECT PR:PROJECT_TITLE Respiration defects limit serine synthesis required for lung cancer growth and PR:PROJECT_TITLE survival PR:PROJECT_SUMMARY Mitochondrial function supports energy and anabolic metabolism. Pathogenic PR:PROJECT_SUMMARY mitochondrial DNA (mtDNA) mutations impair these processes, causing PR:PROJECT_SUMMARY mitochondrial diseases. Their role in human cancers is less clear; while some PR:PROJECT_SUMMARY cancers harbor high mtDNA mutation burden, others do not. Here we show that a PR:PROJECT_SUMMARY proofreading mutant of DNA polymerase gamma (PolGD256A) increases the mtDNA PR:PROJECT_SUMMARY mutation burden in non-small-cell lung cancer (NSCLC). This mutation promotes PR:PROJECT_SUMMARY the accumulation of defective mitochondria, reduces tumor cell proliferation and PR:PROJECT_SUMMARY viability, and improves cancer survival. In NSCLC, pathogenic mtDNA mutations PR:PROJECT_SUMMARY enhance glycolysis and create a glucose dependency to support mitochondrial PR:PROJECT_SUMMARY energy, but at the expense of a lower NAD⁺/NADH ratio that hinders de novo PR:PROJECT_SUMMARY serine synthesis. Thus, mitochondrial function in NSCLC is essential for PR:PROJECT_SUMMARY maintaining adequate serine synthesis, which in turn supports the anabolic PR:PROJECT_SUMMARY metabolism and redox homeostasis required for tumor growth, explaining why these PR:PROJECT_SUMMARY cancers preserve functional mtDNA. PR:INSTITUTE Rutgers Cancer Institute PR:LAST_NAME Cararo Lopes PR:FIRST_NAME Eduardo PR:ADDRESS 195 Little Albany Street PR:EMAIL edu.llopes@gmail.com PR:PHONE 732-235-5795 #STUDY ST:STUDY_TITLE Respiration defects limit serine synthesis required for lung cancer growth and ST:STUDY_TITLE survival - Effect of Polg mutation in NSCLC conditioned medium ST:STUDY_SUMMARY This study explores the impact of mtDNA mutation burden induced by the PolG 𝐷 ST:STUDY_SUMMARY 256 𝐴 D256A mutation in NSCLC. Using in vitro models (TDCLs) cultured in ST:STUDY_SUMMARY either standard RPMI medium or RPMI without serine and glycine, we characterized ST:STUDY_SUMMARY the [U-¹³C]D-glucose metabolism in NSCLC conditioned medium. Here we found ST:STUDY_SUMMARY that mitochondria impairment cause more use of glucose to synthesize serine. Due ST:STUDY_SUMMARY the lack of carbons from glucose to TCA (Tricarboxylic acid cycle) the PGKP ST:STUDY_SUMMARY cells have a energetic imbalance. KP: NSCLC TDCLs generated from conditional ST:STUDY_SUMMARY animals PGKP: NSCLC TDCLs generated from conditional animals bearing PolG ST:STUDY_SUMMARY mutation ST:INSTITUTE Rutgers Cancer Institute ST:LAST_NAME Cararo Lopes ST:FIRST_NAME Eduardo ST:ADDRESS 195 Little Albany Street ST:EMAIL edu.llopes@gmail.com ST:PHONE 732-235-5795 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 SU:GENDER Male and female #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - Ctrol+SG_1_Fresh Medium_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium control RAW_FILE_NAME(Raw)=Ctrol+SG_1 SUBJECT_SAMPLE_FACTORS - Ctrol+SG_2_Fresh Medium_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium control RAW_FILE_NAME(Raw)=Ctrol+SG_2 SUBJECT_SAMPLE_FACTORS - Ctrol-SG_1_Fresh Medium woSer/Gly_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium no Ser/Gly RAW_FILE_NAME(Raw)=Ctrol-SG_1 SUBJECT_SAMPLE_FACTORS - Ctrol-SG_2_Fresh Medium woSer/Gly_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium no Ser/Gly RAW_FILE_NAME(Raw)=Ctrol-SG_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M12_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M12_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M12_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M12_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M12_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M12_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M4_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M4_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M4_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M4_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M4_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M4_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M8_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M8_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M8_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M8_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_311M8_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_311M8_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M12_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M12_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M12_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M12_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M12_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M12_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M4_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M4_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M4_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M4_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M4_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M4_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M8_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M8_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M8_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M8_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_313M8_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_313M8_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M12_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M12_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M12_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M12_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M12_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M12_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M4_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M4_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M4_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M4_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M4_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M4_3 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M8_1_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M8_1 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M8_2_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M8_2 SUBJECT_SAMPLE_FACTORS - KP_+SG_483M8_3_KP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_+SG_483M8_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M12_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M12_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M12_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M12_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M12_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M12_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M4_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M4_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M4_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M4_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M4_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M4_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M8_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M8_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M8_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M8_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_311M8_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_311M8_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M12_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M12_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M12_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M12_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M12_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M12_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M4_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M4_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M4_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M4_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M4_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M4_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M8_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M8_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M8_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M8_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_313M8_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_313M8_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M12_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M12_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M12_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M12_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M12_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M12_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M4_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M4_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M4_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M4_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M4_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M4_3 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M8_1_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M8_1 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M8_2_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M8_2 SUBJECT_SAMPLE_FACTORS - KP_-SG_483M8_3_KP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP RAW_FILE_NAME(Raw)=KP_-SG_483M8_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M12_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M12_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M12_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M12_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M12_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M12_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M4_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M4_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M4_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M4_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M4_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M4_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M8_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M8_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M8_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M8_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_261M8_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_261M8_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M12_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M12_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M12_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M12_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M12_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M12_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M4_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M4_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M4_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M4_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M4_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M4_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M8_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M8_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M8_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M8_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_262M8_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_262M8_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M12_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M12_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M12_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M12_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M12_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M12_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M4_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M4_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M4_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M4_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M4_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M4_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M8_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M8_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M8_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M8_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_263M8_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_263M8_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M12_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M12_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M12_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M12_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M12_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M12_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M4_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M4_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M4_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M4_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M4_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M4_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M8_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M8_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M8_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M8_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_41M8_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_41M8_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M12_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M12_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M12_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M12_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M12_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M12_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M4_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M4_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M4_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M4_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M4_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M4_3 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M8_1_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M8_1 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M8_2_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M8_2 SUBJECT_SAMPLE_FACTORS - PG_+SG_693M8_3_PGKP_Control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_+SG_693M8_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M12_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M12_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M12_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M12_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M12_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M12_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M4_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M4_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M4_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M4_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M4_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M4_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M8_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M8_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M8_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M8_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_261M8_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_261M8_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M12_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M12_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M12_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M12_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M12_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M12_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M4_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M4_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M4_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M4_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M4_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M4_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M8_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M8_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M8_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M8_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_262M8_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_262M8_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M12_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M12_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M12_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M12_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M12_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M12_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M4_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M4_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M4_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M4_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M4_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M4_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M8_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M8_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M8_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M8_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_263M8_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_263M8_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M12_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M12_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M12_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M12_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M12_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M12_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M4_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M4_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M4_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M4_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M4_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M4_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M8_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M8_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M8_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M8_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_41M8_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_41M8_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M12_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M12_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M12_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M12_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M12_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M12_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M4_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M4_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M4_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M4_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M4_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M4_3 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M8_1_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M8_1 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M8_2_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M8_2 SUBJECT_SAMPLE_FACTORS - PG_-SG_693M8_3_PGKP_woSer/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP RAW_FILE_NAME(Raw)=PG_-SG_693M8_3 #COLLECTION CO:COLLECTION_SUMMARY TDCLs were plated in 6-well plates (Corning) and cultured for 72 hours to reach CO:COLLECTION_SUMMARY 60-80% confluence at the time of incubation. Cells were then incubated with 2 CO:COLLECTION_SUMMARY g/L of [U-¹³C]D-glucose (Cambridge Isotope Laboratories) for 12 hours before CO:COLLECTION_SUMMARY metabolite extraction. For tracing, cells were incubated with 2g/L of CO:COLLECTION_SUMMARY [U-13C]D-glucose (Cambridge Isotope Laboratories) for 12h before metabolite CO:COLLECTION_SUMMARY extraction. Three wells were used for the metabolite extraction, and the other CO:COLLECTION_SUMMARY three were harvested using trypsin 0.25% to measure the wet cell volume using a CO:COLLECTION_SUMMARY PCV-packed cell volume tube (TPP). For Kinect release, the conditioned medium CO:COLLECTION_SUMMARY was collected at three-time points every 4 hours after the introduction of CO:COLLECTION_SUMMARY [U-13C]D-glucose, followed by metabolite extraction as previously described. CO:SAMPLE_TYPE Culture Media CO:VOLUMEORAMOUNT_COLLECTED 400uL of organic phase of metabolites extraction CO:STORAGE_CONDITIONS -80℃ CO:COLLECTION_VIALS 1.5 mL Eppendorf tubes CO:STORAGE_VIALS 1.5 mL Eppendorf tubes #TREATMENT TR:TREATMENT_SUMMARY TDCLs were plated in 6-well plates (Corning) and cultured for 72 hours to reach TR:TREATMENT_SUMMARY 60-80% confluence at the time of incubation. For this period the KP and PGKP TR:TREATMENT_SUMMARY TDCLs were incubated in complete RPMI medium (Control) and in RPMI without TR:TREATMENT_SUMMARY serine and glycine (woSer/Gly). Cells were then incubated with 2 g/L of TR:TREATMENT_SUMMARY [U-¹³C]D-glucose (Cambridge Isotope Laboratories) for 12 hours before TR:TREATMENT_SUMMARY metabolite extraction. For tracing, cells were incubated with 2g/L of TR:TREATMENT_SUMMARY [U-13C]D-glucose (Cambridge Isotope Laboratories) for 12h before metabolite TR:TREATMENT_SUMMARY extraction. Three wells were used for the metabolite extraction, and the other TR:TREATMENT_SUMMARY three were harvested using trypsin 0.25% to measure the wet cell volume using a TR:TREATMENT_SUMMARY PCV-packed cell volume tube (TPP). For Kinect release, the conditioned medium TR:TREATMENT_SUMMARY was collected at three-time points every 4 hours after the introduction of TR:TREATMENT_SUMMARY [U-13C]D-glucose, followed by metabolite extraction as previously described. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY TDCLs the metabolites extraction was performed by washing the wells twice with SP:SAMPLEPREP_SUMMARY cold PBS, and 400 µL of extraction buffer 40:40:20 with 0.05% formic acid was SP:SAMPLEPREP_SUMMARY added to each well. The plate was allowed to rest on ice for 5 minutes, and then SP:SAMPLEPREP_SUMMARY the cells and buffer were scraped. The samples, extraction from medium and SP:SAMPLEPREP_SUMMARY cells, were placed in a 1.5 mL microtube with 22 µL of 15% NH4HCO3 vortexed and SP:SAMPLEPREP_SUMMARY centrifuged for 10 min at 15,000g at 4° C. 380 µL of the supernatant were SP:SAMPLEPREP_SUMMARY collected and stored in -80° C freezer until analysis by LC-MS. In the table, SP:SAMPLEPREP_SUMMARY where the genotype of the samples is specified as “Fresh medium control” and SP:SAMPLEPREP_SUMMARY “Fresh medium no Ser/Gly” it refers to unconditioned culture medium (not SP:SAMPLEPREP_SUMMARY exposed to cells), which serves as a baseline for metabolite analysis of the SP:SAMPLEPREP_SUMMARY conditioned medium with and without Ser/Gly from KP and PGKP TDCLs. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY TDCLs from NSCLC. BOX I Pos CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Thermo Vanquish CH:COLUMN_NAME Waters XBridge BEH Amide (150 × 2.1mm, 2.5um) CH:SOLVENT_A 95% water/5% acetonitrile; 20mM acetic acid; 40mM ammonium hydroxide (pH 9.4) CH:SOLVENT_B 20% water/80% acetonitrile; 20mM acetic acid, 40mM ammonium hydroxide (pH 9.4) CH:FLOW_GRADIENT 0 min, 100% B; 3 min, 100% B; 3.2 min, 90% B; 6.2 min, 90% B; 6.5 min, 80% B; CH:FLOW_GRADIENT 10.5 min, 80% B; 10.7 min, 70% B; 13.5 min, 70% B; 13.7 min, 45% B; 16 min, 45% CH:FLOW_GRADIENT B; 16.5 min, 100% B; and 22 min, 100% B CH:FLOW_RATE 300 μL/min CH:COLUMN_TEMPERATURE 25 °C CH:METHODS_FILENAME Chromatography_method.pdf #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS Maven Box I and II #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS ion count MS_METABOLITE_DATA_START Samples Ctrol+SG_1_Fresh Medium_Control Ctrol+SG_2_Fresh Medium_Control Ctrol-SG_1_Fresh Medium woSer/Gly_woSer/Gly Ctrol-SG_2_Fresh Medium woSer/Gly_woSer/Gly KP_+SG_311M12_1_KP_Control KP_+SG_311M12_2_KP_Control KP_+SG_311M12_3_KP_Control KP_+SG_311M4_1_KP_Control KP_+SG_311M4_2_KP_Control KP_+SG_311M4_3_KP_Control KP_+SG_311M8_1_KP_Control KP_+SG_311M8_2_KP_Control KP_+SG_311M8_3_KP_Control KP_+SG_313M12_1_KP_Control KP_+SG_313M12_2_KP_Control KP_+SG_313M12_3_KP_Control KP_+SG_313M4_1_KP_Control KP_+SG_313M4_2_KP_Control KP_+SG_313M4_3_KP_Control KP_+SG_313M8_1_KP_Control KP_+SG_313M8_2_KP_Control KP_+SG_313M8_3_KP_Control KP_+SG_483M12_1_KP_Control KP_+SG_483M12_2_KP_Control KP_+SG_483M12_3_KP_Control KP_+SG_483M4_1_KP_Control KP_+SG_483M4_2_KP_Control KP_+SG_483M4_3_KP_Control KP_+SG_483M8_1_KP_Control KP_+SG_483M8_2_KP_Control KP_+SG_483M8_3_KP_Control KP_-SG_311M12_1_KP_woSer/Gly KP_-SG_311M12_2_KP_woSer/Gly KP_-SG_311M12_3_KP_woSer/Gly KP_-SG_311M4_1_KP_woSer/Gly KP_-SG_311M4_2_KP_woSer/Gly KP_-SG_311M4_3_KP_woSer/Gly KP_-SG_311M8_1_KP_woSer/Gly KP_-SG_311M8_2_KP_woSer/Gly KP_-SG_311M8_3_KP_woSer/Gly KP_-SG_313M12_1_KP_woSer/Gly KP_-SG_313M12_2_KP_woSer/Gly KP_-SG_313M12_3_KP_woSer/Gly KP_-SG_313M4_1_KP_woSer/Gly KP_-SG_313M4_2_KP_woSer/Gly KP_-SG_313M4_3_KP_woSer/Gly KP_-SG_313M8_1_KP_woSer/Gly KP_-SG_313M8_2_KP_woSer/Gly KP_-SG_313M8_3_KP_woSer/Gly KP_-SG_483M12_1_KP_woSer/Gly KP_-SG_483M12_2_KP_woSer/Gly KP_-SG_483M12_3_KP_woSer/Gly KP_-SG_483M4_1_KP_woSer/Gly KP_-SG_483M4_2_KP_woSer/Gly KP_-SG_483M4_3_KP_woSer/Gly KP_-SG_483M8_1_KP_woSer/Gly KP_-SG_483M8_2_KP_woSer/Gly KP_-SG_483M8_3_KP_woSer/Gly PG_+SG_261M12_1_PGKP_Control PG_+SG_261M12_2_PGKP_Control PG_+SG_261M12_3_PGKP_Control PG_+SG_261M4_1_PGKP_Control PG_+SG_261M4_2_PGKP_Control PG_+SG_261M4_3_PGKP_Control PG_+SG_261M8_1_PGKP_Control PG_+SG_261M8_2_PGKP_Control PG_+SG_261M8_3_PGKP_Control PG_+SG_262M12_1_PGKP_Control PG_+SG_262M12_2_PGKP_Control PG_+SG_262M12_3_PGKP_Control PG_+SG_262M4_1_PGKP_Control PG_+SG_262M4_2_PGKP_Control PG_+SG_262M4_3_PGKP_Control PG_+SG_262M8_1_PGKP_Control PG_+SG_262M8_2_PGKP_Control PG_+SG_262M8_3_PGKP_Control PG_+SG_263M12_1_PGKP_Control PG_+SG_263M12_2_PGKP_Control PG_+SG_263M12_3_PGKP_Control PG_+SG_263M4_1_PGKP_Control PG_+SG_263M4_2_PGKP_Control PG_+SG_263M4_3_PGKP_Control PG_+SG_263M8_1_PGKP_Control PG_+SG_263M8_2_PGKP_Control PG_+SG_263M8_3_PGKP_Control PG_+SG_41M12_1_PGKP_Control PG_+SG_41M12_2_PGKP_Control PG_+SG_41M12_3_PGKP_Control PG_+SG_41M4_1_PGKP_Control PG_+SG_41M4_2_PGKP_Control PG_+SG_41M4_3_PGKP_Control PG_+SG_41M8_1_PGKP_Control PG_+SG_41M8_2_PGKP_Control PG_+SG_41M8_3_PGKP_Control PG_+SG_693M12_1_PGKP_Control PG_+SG_693M12_2_PGKP_Control PG_+SG_693M12_3_PGKP_Control PG_+SG_693M4_1_PGKP_Control PG_+SG_693M4_2_PGKP_Control PG_+SG_693M4_3_PGKP_Control PG_+SG_693M8_1_PGKP_Control PG_+SG_693M8_2_PGKP_Control PG_+SG_693M8_3_PGKP_Control PG_-SG_261M12_1_PGKP_woSer/Gly PG_-SG_261M12_2_PGKP_woSer/Gly PG_-SG_261M12_3_PGKP_woSer/Gly PG_-SG_261M4_1_PGKP_woSer/Gly PG_-SG_261M4_2_PGKP_woSer/Gly PG_-SG_261M4_3_PGKP_woSer/Gly PG_-SG_261M8_1_PGKP_woSer/Gly PG_-SG_261M8_2_PGKP_woSer/Gly PG_-SG_261M8_3_PGKP_woSer/Gly PG_-SG_262M12_1_PGKP_woSer/Gly PG_-SG_262M12_2_PGKP_woSer/Gly PG_-SG_262M12_3_PGKP_woSer/Gly PG_-SG_262M4_1_PGKP_woSer/Gly PG_-SG_262M4_2_PGKP_woSer/Gly PG_-SG_262M4_3_PGKP_woSer/Gly PG_-SG_262M8_1_PGKP_woSer/Gly PG_-SG_262M8_2_PGKP_woSer/Gly PG_-SG_262M8_3_PGKP_woSer/Gly PG_-SG_263M12_1_PGKP_woSer/Gly PG_-SG_263M12_2_PGKP_woSer/Gly PG_-SG_263M12_3_PGKP_woSer/Gly PG_-SG_263M4_1_PGKP_woSer/Gly PG_-SG_263M4_2_PGKP_woSer/Gly PG_-SG_263M4_3_PGKP_woSer/Gly PG_-SG_263M8_1_PGKP_woSer/Gly PG_-SG_263M8_2_PGKP_woSer/Gly PG_-SG_263M8_3_PGKP_woSer/Gly PG_-SG_41M12_1_PGKP_woSer/Gly PG_-SG_41M12_2_PGKP_woSer/Gly PG_-SG_41M12_3_PGKP_woSer/Gly PG_-SG_41M4_1_PGKP_woSer/Gly PG_-SG_41M4_2_PGKP_woSer/Gly PG_-SG_41M4_3_PGKP_woSer/Gly PG_-SG_41M8_1_PGKP_woSer/Gly PG_-SG_41M8_2_PGKP_woSer/Gly PG_-SG_41M8_3_PGKP_woSer/Gly PG_-SG_693M12_1_PGKP_woSer/Gly PG_-SG_693M12_2_PGKP_woSer/Gly PG_-SG_693M12_3_PGKP_woSer/Gly PG_-SG_693M4_1_PGKP_woSer/Gly PG_-SG_693M4_2_PGKP_woSer/Gly PG_-SG_693M4_3_PGKP_woSer/Gly PG_-SG_693M8_1_PGKP_woSer/Gly PG_-SG_693M8_2_PGKP_woSer/Gly PG_-SG_693M8_3_PGKP_woSer/Gly Factors Medium:Control | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium control Medium:Control | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium control Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium no Ser/Gly Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:Fresh Medium no Ser/Gly Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:KP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:Control | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP Medium:woSer/Gly | Sample source:TDCLs from NSCLC | Genotype:PGKP C12 PARENT_2-Hydroxybutyric acid 781402 8425148 11412779 7368698 8839324 9807865 8726896 8987341 964314 8861781 8954732 8733911 9321344 8637414 9478125 11537916 8468623 9680559 9642982 801067 8497676 9440879 8685626 10755122 8810004 10254309 9586206 10142748 9226248 9000452 909953 9452354 9976629 872144 8333676 10781912 9922725 8932047 11286487 8797612 10285019 10488677 967998 8959526 9176616 912378 9811547 10394862 8950752 9285937 11325293 11319785 8219593 8979437 10876654 10644004 8793344 1096512 12254898 12663496 10329062 9377065 10216071 10883654 9845473 995733 11023175 10855706 1154996 1035823 994662 10098875 1164211 9911285 10915182 10176859 10319282 1094154 11385021 976012 1131613 7916627 10452962 1220224 11001225 11212652 10955509 10768145 9632382 10694984 11201019 10603276 10628859 11142991 9050282 10459382 9759716 9527401 10066119 9257606 11371991 12613751 100876 1195046 10541679 11240027 94267 6775193 10532604 6584104 10464315 1184662 11367835 10662112 1094807 6379631 9496194 10128194 10497352 10198344 10728268 11089979 12007582 11759915 10195079 11006669 9219824 10904029 11097738 11489069 1234677 13241755 1191092 9606188 10509106 1140334 11023625 11116701 1096835 10448177 9733143 11035565 906295 8321837 9394554 897364 11221204 10724009 C13-label-1_2-Hydroxybutyric acid 425495 651975 842604 485544 204835 623182 486406 489334 565906 336203 570939 465841 375875 436807 73434 645501 669902 74279 682095 540382 511399 533633 40199 725186 476468 657197 499858 641043 590804 478166 534444 501406 660447 475637 717055 718996 446756 514554 804492 496158 546116 447096 500867 358796 265324 353495 614561 721991 532413 497873 510172 493108 407621 422026 555487 547142 488535 716334 652247 739779 667506 504691 525818 678577 675311 512975 622135 507432 574641 71236 537915 644957 654087 479946 56935 687229 564069 565604 835386 575738 529781 476318 518062 558912 624313 585189 365357 493826 475686 609749 532431 429021 497774 626077 689579 656904 480451 485168 62352 53988 420527 658213 541244 756828 561997 686767 430996 422726 269407 341759 56165 632085 558614 483016 584661 367963 381772 469755 519702 571396 538187 579627 763218 660363 490436 637614 529911 479899 537831 515952 734492 756463 546509 559736 5099 581272 517555 536871 493985 511252 561602 563107 652575 545138 501162 625839 576547 530597 C12 PARENT_3-Hydroxybutyrate 22420061 27618953 31493875 23614408 10063418 11296496 10303551 15805002 21054248 16512742 146425 12330888 1172759 12132102 14350202 16224605 19679217 23010911 252265 14658084 14795259 15633495 14430961 1966522 14391552 2188898 20780517 21031542 17238728 1628635 16509177 12127094 1310883 11862047 18589819 20019102 18991362 1288334 18171336 12519421 13444231 13892292 10738148 17507186 17814817 19587292 16169894 16656433 1383735 14086564 17892538 17269842 1698552 17513038 2198588 18023838 13679386 16707177 20378425 18477062 16018481 20871881 23690544 23745702 17485117 17004484 2055695 18526186 18739573 17968075 21982481 23205069 27897572 192270 19694242 17119338 12584212 13061835 15569642 1793695 20769727 15644225 176007 15997952 16035311 16346719 13880161 12237347 19794875 20648298 25685636 16455808 1729947 19354939 12123012 15674967 13609395 20717469 1930417 21256558 1669592 19679867 16726855 19312889 16652658 18166938 20390895 14830631 2294402 9181238 18208562 17404777 16605123 17540681 18760938 14221389 2564387 22799198 20148552 20117494 19821695 16369975 18053542 16302139 21152698 23892761 20886033 18199983 19386795 2016838 15490605 17192333 14433402 20508795 20368975 2463698 14347862 17371475 15565773 14145305 15104783 15658317 21417592 18922883 1914063 15221697 1772263 1752803 C13-label-1_3-Hydroxybutyrate 1151874 1613942 1733455 933466 10959 88755 138581 535648 446938 364908 174229 142465 66749 120554 245717 101916 496679 892792 598781 23305 136471 177644 100972 582743 446355 933504 451346 486044 427868 308707 88109 10008 181359 147815 900188 436557 507756 78983 395101 163992 79728 234259 89888 673254 430498 528814 208859 117511 97827 11116 390459 17569 318096 874766 527607 159098 98397 191025 724429 94684 84831 747609 822832 917731 202452 384185 636883 228928 108024 477241 734152 593872 528188 406064 116006 282872 157675 171087 398407 466982 529778 398071 286761 468936 212291 113789 132112 86694 897332 499867 766568 225681 141771 332081 237693 260763 177058 343848 57086 413205 775755 91412 1017 444753 0 118019 864886 545515 382592 232476 653452 232624 425845 797821 206615 810116 609579 439096 358545 530228 261232 69938 155026 79746 443433 458988 491835 262157 440678 639419 141725 100636 115838 678568 400061 673533 234261 321866 7123 152892 261513 127847 490466 464453 565226 88785 339521 436467 C12 PARENT_Alanine 39329178 45558991 54719906 38086966 38633447 45563078 38988772 41459625 49206459 39283825 46613953 42611338 40739116 30537278 37020866 40978359 39364025 48578838 51289972 33139809 37560603 38080475 31491453 42723962 32127744 467221 42932803 44960178 388558 36726922 40027522 32658603 37405238 31811872 34751709 51650225 39785738 33424147 47503847 357469 23876033 25925406 2315512 34010872 32160512 33727322 32487088 32414862 27564525 31013853 39580697 38486666 34158597 36455212 50322862 38313684 32550781 40726125 55339694 57644606 58738156 47816628 52954981 54604806 53996969 53200175 5405125 51802284 47547847 44923378 4308555 50510662 51714284 48346616 48307334 44708634 38147438 44262528 43634909 4708055 49602316 28317472 44941159 45129166 42652859 50731759 47456978 49210875 46413403 49252575 552348 46455591 50120266 47690116 32189134 38277338 31905503 41172697 43173112 42321716 4400965 48816684 39356734 53320319 54440019 52945306 44386925 26539553 48608009 17574677 50899575 53143594 47782478 45882591 43909816 24001838 42968209 51118609 5345165 43301259 50029328 37347566 4276035 47565997 48689953 50359316 44578678 40329541 42927888 46099184 48504291 54645831 48975397 43503297 492594 58010988 45377872 52529994 54461381 34090716 33804956 35990084 43815166 35823603 38218512 31752303 42758778 39213328 C13-label-2_Alanine 0 0 95826 0 4381912 4917791 4027553 1547265 1643111 1472704 4125591 3746386 3396801 3683248 3398735 3964016 99389 1029755 1092458 2859429 2452031 2384204 2290291 2866274 290834 87299 1082636 907595 183482 1850656 2272847 295102 2828823 287964 777368 1467863 901658 2221038 3287214 2280096 2412301 2891829 2168884 747611 747168 827538 2322529 230279 2289122 1918327 2994001 2758618 598882 615624 1089789 1908034 1626355 2156135 1864135 1968572 2541709 329714 474226 554171 1291038 1334175 1622772 2053652 2456013 1798391 335155 559878 431404 1135077 1541362 1266649 2170794 3063524 2443233 714359 954925 544572 143283 1869031 1597991 4034872 3221882 3354988 929149 1010338 119286 2372492 2796738 2412364 1526024 1875749 1538781 405866 400926 470357 1859015 1624142 900856 2245302 2670288 2429458 588415 364516 563354 542395 1334907 1863079 1741386 1766691 1593873 179466 440831 55873 1437565 1147416 1806333 1510532 1858891 1692533 294203 439883 451665 105261 951785 1011023 3618056 3868988 374128 804611 1031836 1216188 2644468 2824533 3470192 1443714 1694922 1626835 380061 45021 2929 1166992 11481 991243 C13-label-3_Alanine 248607 491075 254887 368611 81272525 94315175 74742981 29316112 36216366 25502845 77436656 71891181 62789794 61871544 64892194 74916856 1998677 19365402 20271545 50246325 46365503 49478588 35880878 49488188 38542862 1468493 13711614 15277014 31189509 32051197 35771309 50718134 61303156 50783459 1760343 27186134 21476712 40365784 65346344 45966425 45304753 49066338 46878066 15860797 15170119 15938516 4563645 4605795 40249847 34610291 45731959 49041453 12184921 13526062 20245558 34772938 30263125 37688784 42658641 42714259 50190512 9830356 9629043 12297885 29473912 29282397 33930853 44617616 45764009 39382353 9060415 11869484 11938326 2836195 31692525 27228441 38614572 562440 47153378 13939775 168005 9204098 32807953 37422353 33723281 64139744 57670025 64840569 16856556 20111075 24868152 41114325 48605203 41869425 35020575 38891303 31909691 10183035 10513873 9053421 33495706 32888591 25250419 48776362 46447472 50424259 9826559 5471441 12617293 11562559 31929978 37074647 40406078 37860859 42121212 5961229 9905766 1306905 31643125 26977562 34165291 31467759 34714659 37719475 8644838 10219654 8630596 243715 23478436 23420138 74115331 83763444 74867731 18560612 19748325 24899495 51161547 54908869 62267269 32432012 373496 3520745 9117666 7818377 767739 22952444 28613388 23663725 C13-label-1_Alanine 1027533 1251867 4900478 1124189 2102735 2268644 1924033 1695972 1618043 1240667 2366055 1931698 1804367 1701071 1674229 1997412 1379514 1606744 1994878 1822265 1621071 1561371 1804731 2310494 1526333 1821368 1580964 1373171 163371 1725471 1906853 1485975 1910821 1826259 1303516 1688437 1516582 1394439 2265974 1547255 1017222 1196074 1079809 1112716 1167599 106048 1333753 1309851 1140383 1453074 1847818 1714635 999617 1345039 1817715 1651852 1440241 1876315 1710028 1904952 2264649 1472573 1697308 1718852 1881925 1842138 2085116 1735652 1545482 1617921 1228864 1665957 1758991 152416 1461914 1223774 1673546 2339558 1892673 1177314 1754494 1111928 1972736 1670795 1624299 2332826 1921881 2263414 1465552 1618293 2101398 159084 1820617 1999475 1196093 1366993 1300111 1306032 1286943 1135986 1288828 1803471 1440701 2179374 1776197 1569006 1318896 926482 1678455 662429 1675024 1766097 1837847 1488736 1578209 728233 1312501 1720927 3984283 1394989 1723892 1114292 1419038 15674 1745403 1633053 1639156 1262943 1535383 1753199 1957715 2075238 2246649 1363279 1519537 1984845 1989994 2102234 2359979 104309 1345556 1332272 1348453 1052834 1377084 1111528 1543846 1411402 C12 PARENT_Aconitate 10050846 10443468 16003511 9384994 16375277 17787445 1643685 11201566 13746289 10949684 17376759 14999931 1480448 27026559 26887453 301905 1406663 18397389 22881608 23633858 20795383 20681012 19913961 26412856 20907667 16693808 13274438 16498052 18302894 18055845 211193 16859309 18093669 15046139 12223641 17437055 123795 1418523 22601833 1283185 19721619 21556312 19872562 12710081 11652931 12504598 18967045 19214081 17111244 19815245 26044583 29062697 11190596 11904718 19240319 20713964 16097967 21015355 31143434 36594612 21515933 11141031 19627762 22631256 26167895 16763434 32185956 2251388 39926009 33221991 17862655 1796535 211580 15792755 34950984 236677 2293335 17737823 29512328 13558695 23003594 9265788 13434145 27374834 23133588 1819205 27046209 19407192 13522638 16715289 28968156 21359836 25140373 26963203 20042142 23184323 20629061 1328137 13917633 13462731 22139914 24251514 1881278 38027653 3303605 38089153 14210719 8250048 16742373 4842222 29674984 29644091 21782533 31178041 33600025 426727 21647736 12551528 21959712 24956025 21033888 21246925 29317878 19308061 15752694 18950855 8450807 18145183 20858923 23515902 31774328 40457309 33357925 12474949 15781706 25962458 21447825 26869762 17335398 1859788 2089683 18631298 12730534 11456616 11792898 15199489 20700533 18304339 C13-label-1_Aconitate 637222 60934 846061 677586 1336503 1440673 1465104 944292 987724 743036 1216669 1143434 1037949 3028355 2729483 2904576 1189948 1512464 1534649 2398783 1916846 1984771 1419832 242566 1892935 1262847 1018219 1226325 1665667 1372276 194357 1243652 1477685 1112986 1043189 1072801 623802 929951 1704358 99909 1764069 166129 1956623 966996 749244 849864 146866 1618936 1619913 155917 2133075 2989323 797799 782492 1628099 1763331 1613767 1703747 2376922 3096088 1682724 837977 130069 150236 233148 1435392 2340797 1696804 2863124 2318906 1184495 1266924 1380429 1021676 2369607 1621594 1927202 1450136 2126247 854255 1671675 673343 899461 2058497 1760526 1816041 2367694 1374154 1247482 1134822 2146495 1632732 2101461 2326723 12651 1552817 1361623 920754 1092075 943975 141672 1785125 1259236 2861854 2432017 2833851 1026362 611389 1311811 201906 2079293 1858509 1474606 2116071 2521531 349312 1387578 74015 1428646 1852676 1361536 1546906 2161052 1374195 1048401 1374497 636401 1540615 1584483 1491917 2464464 3531291 2164885 997679 1095277 181564 1678735 2069356 1209295 1286617 1336233 116798 827525 757175 631287 1044738 1311241 1271971 C13-label-2_Aconitate 0 69589 0 55553 2706788 3066676 2326561 404166 430049 23945 2421327 2049556 2037224 9698065 8215695 11182063 1514893 17351 2523106 6573273 4944977 5593123 3843284 5115771 4169842 1124604 833344 1406567 3202158 2744643 3465935 2123873 2418837 1878491 45918 551475 411176 1472882 2103584 124814 713199 8101318 7673893 1124353 954268 121339 5241232 5289864 5039853 3570251 5107556 6033228 890138 88063 1555271 3096453 2383259 3404916 2741607 3342532 2216512 1804 106178 450241 1739136 1373132 2337404 584126 1365889 892621 0 66344 0 214989 576538 256432 290294 2349384 4104347 673599 1066489 478608 1651524 2751349 2577978 3097274 4060408 2803647 10485 1125027 212569 2567981 2975113 3693534 1402284 1268969 977162 103714 0 0 1112486 771607 686323 2407184 2236875 2777138 136982 0 245171 9242 1325186 1724627 187656 161904 556827 0 73064 0 353575 74703 17241 2235088 3294998 2025381 64151 85264 251738 1682024 211879 1930392 4857341 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C13-label-1_Glutamine 176136088 1962180 20811615 16840355 53127981 531834 58922319 125819062 138315688 1325026 79475994 7309145 83198169 27616978 5775385 57150806 127727462 15626665 179312162 62323181 889169 8311645 85623494 110358638 85247156 173359312 160090262 167239938 116237912 1137654 118746812 71174281 73645669 69674381 113221888 170184362 146828938 86718569 109017512 924435 30587991 36484925 2981745 130831188 12771725 131280462 6651405 77412531 63503719 86637906 101748806 100099194 137039162 144340438 182653862 123679338 110268912 1210262 163730662 1647245 1611987 171189288 207871838 2044220 194139838 176891262 186033688 167534688 165171188 154850288 179491312 204060762 190769488 165166162 1823428 174010188 1286111 12253065 128437538 175453362 1927386 1192040 15188125 14550215 1517095 130154162 131566438 1222582 179973888 190380162 197851088 149025362 1569622 149182362 116506325 138471538 130593112 1606840 173999338 170575812 152866788 1772393 150875012 164079312 178382138 16975845 1794088 101835056 193307088 52187641 189758662 172939138 152270812 168464138 16406145 86135325 162669238 194121938 176633112 168229888 170713988 1493731 160374112 158213938 2040046 210227925 1717639 172788262 177069138 180667762 136042988 14859805 154164538 1752554 19154865 2141096 15414035 165447338 15737855 131069412 138995712 14830195 170146962 155430512 163053338 137141812 168837538 159068662 C13-label-2_Glutamine 3411652 3450559 3119075 2988522 2372996 2897342 2848448 3112918 3079895 2991779 3059192 2968659 2814408 9757238 1231981 13152148 7336275 7169787 7386144 12387416 10805791 9944947 5921311 7106113 6170246 4469664 4183048 5765275 5860704 4989326 6944859 2522999 3431739 2685166 2142631 3525299 2742676 2657248 3536736 2934703 718958 8167996 7219559 5352689 4954817 56619 9098305 10074243 8626575 4779017 5498233 6084658 3427858 3504713 4885156 4859445 4259854 56886 9273995 10165272 10346834 3933395 4752471 4704819 76188 6400495 844358 3520352 3509402 3692886 3555931 343346 3481297 3576957 428733 3647186 4093901 4773786 4299608 3552629 4022888 22690 3995569 4016471 4104021 3457858 3377713 3270883 3738495 3689985 400895 3299732 3843144 3178288 3137918 3919191 3346667 3142323 2941978 3306486 3703732 3981807 304456 7203068 8612276 9451041 3498214 2021679 3836402 164783 5799219 585998 2821816 3256592 2829942 1382533 2499959 3291674 3190037 28130 3185935 3016584 3809762 3265531 4008497 3918758 3225126 2765299 3034638 3359905 3615128 4069205 437663 3206719 4228361 3977957 4009854 4235479 3442204 265802 2828426 2782653 3243301 2582824 2695407 2564416 3443739 3050962 C13-label-4_Glutamine 0 0 0 0 552831 36604 302235 0 0 0 186731 185005 127544 2832796 2985223 2729002 697148 4745 484641 2601784 1886096 1629906 1293826 1764065 178417 23048 15441 220429 100906 869228 1176415 358042 514706 236891 0 0 0 100575 0 0 1383772 1674447 1436785 143697 17022 146597 1242963 1319491 1256907 881513 112712 1152448 0 0 224232 225045 421293 642592 144345 13848 1644989 0 0 0 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38367 496276 649373 47195 329873 438347 395047 531079 488962 605934 490964 459749 606265 520253 529841 523356 455944 469848 330531 315456 571518 464744 668035 432687 351237 378698 464337 540224 62304 518436 595661 625789 575284 663421 597525 492814 376851 399465 506768 411496 485772 351753 576712 515727 540234 535354 289609 487469 651791 660846 710398 7782 656448 689026 706118 673884 580765 734305 687024 697715 796093 614994 700779 600777 579103 681909 70379 854315 729481 386153 709872 7905 740637 645414 83329 695496 78688 624044 441311 644884 498172 602401 498221 3837 564591 351312 560337 451349 422381 447001 676799 454685 631126 867337 511912 586251 633829 460852 581709 716757 722152 600228 666229 393927 429294 73242 588694 592144 702745 735348 563599 798771 827572 590275 732291 624808 808753 581148 786566 775249 777793 65353 600708 927064 726058 721659 782922 676366 598593 537291 382821 646598 562835 68684 49865 219258 C13-label-1_Glycerate 298177 365689 421289 523745 250967 3194 344202 386162 429715 364939 650667 412848 501956 587636 342241 9461 386743 495904 1258019 526245 464116 590222 261488 776266 315073 380861 479666 39322 833098 324923 362085 378539 526011 279247 403918 1739889 639729 309673 348063 790142 534859 467442 498853 372695 283579 571576 372779 437615 604423 429416 361836 309169 265901 388474 315751 474526 189199 456797 482468 372248 1130696 345649 803704 314034 88076 493078 939921 1086655 473182 444293 573682 731077 629256 425872 1145438 709031 920282 1175196 607596 74782 1261489 437248 627278 620241 498383 55124 61551 605685 865526 592384 930809 441565 492386 912797 586054 644351 340435 867051 557038 1121663 512674 415673 818622 1072063 1065969 866288 870692 450511 800151 260948 713014 879414 615076 662493 1241134 396671 488067 928222 484021 605054 386791 138074 720845 1179667 1083943 94147 886645 433355 1309879 663802 308924 689404 830716 352288 1230481 541912 857281 727958 1365097 450647 644903 508422 397553 822623 333055 741374 347055 443258 C13-label-2_Glycerate 6989 88054 103601 0 75528 0 0 0 91254 0 0 56732 0 68196 109463 0 0 118391 94262 0 0 0 0 0 98905 85341 0 74226 0 0 65661 0 0 0 138471 103552 129589 0 124626 0 0 0 0 6035 0 0 0 79235 60444 0 0 208898 0 140009 0 0 0 0 0 71511 72244 71793 0 0 0 0 72039 0 0 0 6837 0 82896 0 0 71184 0 58336 0 73562 70938 6817 68445 68734 6769 65825 0 0 0 0 107078 71681 0 87124 0 0 64416 0 0 0 0 81269 91995 0 0 88522 61234 0 70504 0 0 0 0 0 74696 63119 0 67285 6796 0 78293 63867 0 72075 0 70092 68445 0 0 74294 72529 0 66682 0 60711 62403 108944 0 0 100419 0 0 0 0 67578 0 108442 0 C12 PARENT_Glycerate_2nd Peak 16926378 18862262 20807595 16071644 11879454 1692315 16534061 17126048 19534005 1685818 16430792 17269766 16250353 1333753 17081033 16777427 15416717 20586012 21884731 15352475 15823372 17630723 13936995 187807 15526777 18114069 13525344 18168338 16831544 1657772 1779042 15453864 16620912 13747386 15165922 21052262 18441995 15931083 2127408 15011581 13666761 16278755 14736914 16989052 14003411 17303267 1551232 1805183 153934 15939027 16556959 18786995 14157119 15659358 22241302 18071761 15320361 19425538 17771461 17795155 23202333 22531961 17775061 18230794 18320175 25344281 19089886 20413358 19971155 19020286 17427327 21432095 18104512 24164167 19517456 18693988 1908998 22321906 18805492 25055586 16952567 13847089 26835562 2021185 18626233 23264839 19364633 23438873 16463869 1781502 21446138 1513378 21403869 178556 1393882 18000794 16828155 1626807 1879065 19242105 19195914 23182239 19670419 1934898 17692833 1729273 16731842 10800971 19082969 6924073 16796667 20167039 24898983 15706839 2121523 12588696 17397858 20761295 22103044 14950788 26115227 18539475 18662438 2519037 18766017 192483 22067033 18326188 19334423 17422255 16754256 20155092 16137119 19920158 18911014 19349656 17831786 19570948 25953969 17465905 16601656 18734795 17240859 1774955 17791967 1663478 1745158 17935506 C13-label-1_Glycerate_2nd Peak 298177 365689 421289 523745 250967 3194 344202 386162 429715 364939 650667 412848 501956 587636 342241 9461 386743 495904 1258019 526245 464116 590222 261488 776266 315073 380861 479666 39322 833098 324923 362085 378539 526011 279247 403918 1739889 639729 309673 348063 790142 534859 467442 498853 372695 283579 571576 372779 437615 604423 429416 361836 309169 265901 388474 315751 474526 189199 456797 482468 372248 1130696 345649 803704 314034 88076 493078 939921 1086655 473182 444293 573682 731077 629256 425872 1145438 709031 920282 1523078 607596 74782 1261489 437248 627278 620241 498383 55124 61551 605685 865526 592384 930809 441565 492386 912797 586054 644351 340435 867051 557038 1121663 512674 415673 818622 1072063 1065969 866288 870692 450511 800151 260948 713014 879414 615076 662493 1241134 396671 488067 928222 484021 605054 386791 138074 720845 1179667 1083943 94147 886645 433355 1309879 663802 308924 689404 830716 352288 1230481 541912 857281 727958 1365097 450647 644903 508422 397553 822623 333055 741374 347055 443258 C13-label-3_Glycerate_2nd Peak 864203 1477255 618446 1327051 2501865 277781 3909246 215807 2541648 2324186 2795209 2770424 3002717 2420915 284088 2972762 1558019 123093 2158427 1697028 2431963 2336383 1457821 2049206 1637949 1285604 1073236 1356883 1777367 1661256 1784116 2391308 3028792 283882 991771 2096433 2150715 1776642 286825 1995257 3577222 1597957 3823025 1981337 1472504 1360809 3096712 3078226 3644788 1131782 1869852 1973241 1284204 878121 178809 1866158 137693 1863481 2216563 2172511 2842938 2257238 2173496 1823238 2321898 1987851 1875805 2446616 2560309 165579 1902413 1859234 1510627 1034559 2116348 1606659 1388572 1696754 1603145 1437243 1659853 736528 1771319 1854051 1718405 2832071 1845412 2117012 1830742 1723836 142929 1642391 2152416 1831466 1297931 1511485 1070546 1680018 1343191 1083287 1175832 2355958 145213 2362425 2046303 2120257 1981554 9269 2352234 749695 1960148 2359724 2214071 1837784 2351232 954999 1780569 2055976 2165088 70718 2096992 1840661 1753501 2158086 1874272 1180762 2018633 971431 1037199 1732713 1273837 1634244 1682407 1855649 2628049 1496842 180765 2173398 2223033 1741698 1149541 1435192 809507 870554 1293556 830633 1913968 118215 C12 PARENT_Glycine 12410284 13728138 6441253 3905151 11057224 12140622 11327666 12545123 15366994 12874919 12368571 12204354 11801528 9064412 12121112 14046434 14504294 16734433 19274292 11180304 12516666 12929109 12637902 16577044 13019543 16777542 14651883 17180086 14561995 13493883 16299323 2118776 2814696 2191935 3207029 4481871 396813 2359048 37570 2633105 928316 998594 748064 155119 2111554 207818 1287949 1342044 1013956 2941618 4421009 4590531 3331079 4388533 4738062 4167182 3312859 4497147 20095989 18611612 18497548 15552648 15659292 17192817 17079806 18210417 18892527 19892238 19016538 16845136 13668398 1538823 16325339 17494945 17684045 15575612 16401158 19127961 18473695 17867375 19007169 10438981 19194856 19030845 16396727 18684325 15830058 17635167 15070167 15693475 18862908 15051931 18171056 16774586 14409983 18466664 16493025 15692362 16590639 16288725 20008827 21735461 18329139 456778 4603255 487207 4237723 2747132 4579911 1851693 424661 4990458 4581143 3895571 3959845 2481042 4282057 4927267 4894302 3681844 4455498 35700 39600 38500 4378506 4566088 4474647 3983277 4076121 42700 3351983 3912291 3221508 3750167 4519172 4705614 3859364 3595955 3954478 3340987 3556522 3386356 4754086 3668434 4448811 3095955 4274953 3827835 C13-label-1_Glycine 369991 40675 10802 62623 298676 358466 31197 321489 497963 279893 379678 243981 363674 404757 422219 466108 371716 354642 540886 359179 359518 472607 424578 501755 396096 342913 405848 342755 39892 374271 307022 55952 7897 77243 76044 7899 7114 80238 130941 0 4327 0 0 0 49921 51802 72026 57761 0 15184 78293 96598 80437 98635 128788 160053 55807 7615 586415 427367 498467 252579 527812 408489 438721 411562 535314 428018 481047 46005 300617 479654 465215 376933 398224 375215 417679 426415 402243 39351 45866 113344 422632 4445 442633 562803 41577 549975 487351 469228 500679 414136 444749 420251 302078 687868 389957 508234 303535 414833 599174 532895 524674 71751 92788 203127 86097 0 88047 0 86856 85463 77965 7225 53016 61312 61381 149806 90618 132759 74905 642 781 581 88632 82244 0 61102 89905 707 6136 98278 87575 58927 85592 92679 65253 7638 71828 82234 7927 11706 94238 71707 0 72716 148125 73473 C13-label-2_Glycine 61331 73923 0 73147 2159155 2247862 261765 628299 764241 657683 1897471 1993404 1690551 248709 2279168 2966874 785451 683442 654607 1922517 1442964 1880365 2459926 3311012 2432418 651719 621247 808604 1940084 2011337 2273363 1068334 931181 864923 409908 583152 563108 573786 1239636 895224 75656 73946 6079 160847 324095 295187 92805 194757 886 1266064 1873908 220011 199149 259426 490141 1059016 901941 1118975 1013001 979927 1083399 327962 178028 140644 525921 706266 726685 757974 6170 690631 78014 229025 96618 401603 482221 502646 570366 684402 794546 149533 154334 2891 64749 499606 573085 1854042 1473973 1756879 481494 555589 628398 1033102 141601 1300543 92179 814067 1001804 272001 311314 275607 837986 1029476 773058 84492 66283 1024821 161803 89215 114335 319335 514057 577025 298336 241103 392009 94559 97532 83026 301164 205201 248094 618 1040 654 99085 99937 70113 64731 115335 734 189832 220937 171631 7723 209601 221228 27345 243181 312932 238148 45488 325078 99981 15087 183416 287988 399686 433885 C12 PARENT_Leucine 13424529 14917556 15990363 13356035 8765679 9505781 9267715 12161155 12603088 12382568 10568220 10307727 10459321 5009720 72884815 75917425 10493257 12039580 13460068 72356615 8678015 8771547 9390629 11524396 9394974 13949221 13625373 13853560 11219285 11131796 11365587 9571044 10408605 9753526 9714209 14627697 13318817 9783655 11734636 10834131 61700205 65074225 60410955 11032716 10928852 11451673 8038852 8591999 7730400 9710397 10439440 10692203 11644169 12388685 14914664 11714505 10494565 12192960 14270625 14342537 14892536 14306768 16391344 16107957 15911632 15348460 15394893 15964537 15249047 14321941 14706988 16580272 15491416 15714512 15804148 15125637 12911728 13889459 13570003 15263068 15503819 9404891 14474104 13884000 14224329 13098421 12383363 12360280 14194357 15134127 15778597 13314651 14607695 12823435 10942633 13004227 12023497 13048981 14154948 14285205 13507608 14870328 13056547 14287243 15441321 15008131 14308864 80210065 15566415 55140205 15423823 14624343 15051148 15702869 15728805 7633220 13262697 16432973 16295064 15128201 16165411 13942713 14644724 15792931 16415061 16538668 14638365 14979280 15070640 15947077 12830803 14250295 14555105 14158129 15729148 17015618 13981824 14583508 15013173 12064356 12890119 13513076 12544576 12842021 13607715 11890127 14336600 13703987 C13-label-1_Leucine 89933925 99992294 105642338 91325369 58451656 64072031 61297581 79717825 84204531 83879081 69746006 69081575 69735138 33609791 49072766 51228975 70212131 81007019 89157669 49187234 56777006 58393375 6369185 77765106 62420044 95977719 92328681 94513781 77570231 77844044 74628219 62708069 68831006 64541381 657929 97921669 87014244 65938019 77332319 71426206 41025866 43500747 39890891 75827294 73233469 77772181 539729 56518794 51536553 655852 6865395 69526731 80760931 82492594 100140619 78699131 70240806 81994931 948050 9715335 101789569 95517769 11128055 108590388 104021281 10360455 101045425 107221838 102516969 98524681 101236031 111130712 104934362 105988988 106553988 102208894 86661506 93062144 89446106 102579731 103143975 63118569 97426775 9329675 93306619 88221569 84502375 82385881 94599381 1025377 10733065 894314 98764806 87052775 74414031 87472894 81551131 89391506 9586115 970919 917102 98513969 88148081 9577185 102942481 102285569 94608119 53218819 105921488 37807941 101908119 100199019 102269881 105906338 105902338 51424025 89162231 1073682 10940255 102004769 109380512 93908275 99339944 108528462 108997525 114820112 99100881 101544194 101587956 108076162 8576585 92842044 95562831 96819925 105688212 116522238 93952181 10063175 10127355 80380931 86669831 909659 85729119 85718394 89646331 78682175 9743155 9181115 C13-label-2_Leucine 2379101 2577069 267055 237362 1454726 1815355 146515 2119498 2375146 2078499 181023 1790082 1818526 840621 1353795 1334656 1525765 2254149 2469632 1223108 1562679 1494417 1591476 1942866 1698555 255798 2265249 2398783 1803978 1869729 1665294 1634696 1745592 1744823 1732618 2182088 2408123 1704246 2415519 1698505 973358 128963 1039315 1877071 1779078 2011995 1465616 1493022 1219312 1684667 1783815 2000161 2074659 2016355 2843646 1922314 1925446 2028015 2457827 2748121 2460631 2377743 2906951 2798009 2509105 2687402 2347603 3005509 2373149 2363152 264273 305202 2628993 2764941 2822159 2406042 2266082 2345685 2735673 2903407 2582112 1642792 258895 2642057 2391088 2053948 2178692 1963988 2552109 2373754 2945934 2266785 236338 2172698 1841665 2205447 2195497 2268151 2450773 2596166 2354742 2484945 2193676 2305951 2476688 2669458 2271445 1437112 297041 989613 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193061262 16693235 169700512 173162362 183347788 151017088 160725812 17049235 164860938 1792777 202112562 15512055 1706840 175111888 154872188 142554688 151995362 143625862 139628838 15271915 134230638 164561712 156933138 C13-label-1_Methionine 7853213 8605313 10230934 8274441 5539032 5592467 5759644 7657976 8458209 7435162 6736777 6126064 6933344 3877008 5396316 5426928 6353952 8526495 9575994 4960195 5954181 6107976 6042936 7505651 6316201 9524012 8782259 8980594 7051549 6781753 7080327 6222714 6127851 5797239 6103775 9076763 8140284 591717 7971398 6850394 4927389 5460922 4864792 7421502 7285884 7685748 5734019 6487726 5147393 6185505 8016713 8057859 7530619 7360491 10311138 8922588 6539991 7721473 9165468 9360825 9828728 8422252 11397375 10373259 1014265 9940891 9834706 9938746 9306524 9420327 8985085 10424315 9124363 9488562 10116819 9572043 8043813 7977448 8275026 9081984 9360684 5629746 9235938 8274349 8028362 9413363 9000969 923177 9509846 9931155 10526749 9365994 10246888 778444 6664192 7953141 7753306 8111516 16745898 8858543 9022281 9624694 7750914 9813948 11105656 11650529 8858144 5127073 10912605 3405287 106410 9063477 941526 10152862 10531696 4501376 8583146 1019593 10881452 9114731 11050719 92043 9786005 10543909 10719135 10160725 8787718 9997129 905105 10213818 9577987 10343701 11491834 9080468 9672016 1193819 10377155 102727 10962249 8454922 8192562 8191655 7842477 7531412 8204126 8065898 8959166 8669835 C13-label-4_Methionine 0 0 338196 67125 1814617 1754084 1747291 267617 138281 140085 1229483 118997 1481109 182396 1714047 2400816 388899 196853 365694 1274009 1013364 9431 987765 1418447 1039002 130288 79236 100359 778428 740849 837089 1157116 1544216 1111387 137299 278605 129625 865342 1412327 116075 1875835 1971789 208417 188753 36694 280219 163751 1599147 1559502 942107 903738 1275658 79502 77506 166881 816128 609427 875001 648313 226218 794848 0 0 0 197297 595845 341764 1049192 1150025 765058 0 95863 82261 497633 852246 662838 2122162 192604 2392617 87051 23812 0 1276498 1326256 1268651 2021292 1889632 1643313 119127 191774 28902 1225293 1457416 1024164 599329 561494 57251 0 0 0 323054 574586 266813 118566 966651 911722 0 0 93136 83527 592981 432546 640084 601066 686018 0 0 77296 470508 359854 457411 941612 905984 1054912 0 0 0 531081 439129 285883 1107174 1448276 1371171 100711 76018 89365 780967 945743 1055125 211799 50666 29092 0 0 0 23767 194064 241385 C12 PARENT_Ornithine 56772938 61709231 63254444 57440538 53900144 57656119 55759469 56210031 54901175 58559156 56525556 56939144 55194581 51109578 57837769 65346212 54779675 54842775 68962644 55796219 55273725 58560006 52659119 63155256 52910731 63741194 61022019 64631894 56229669 57463325 5980985 54128656 59241206 54131206 45991016 66029669 61226381 53688094 57295444 5610335 55016019 57851506 56061775 59219394 58457431 59327556 54314294 58342356 54277569 53470394 58783219 58357044 56451519 57196569 68914869 58005756 54938375 618527 64008231 64010081 68720644 63196188 75965356 70586906 77629756 67929469 69970119 7269195 70480994 67316906 69441781 760166 61720494 69089975 75609169 71967306 67271606 70109669 66011019 69888881 68385969 42502084 69084838 65651406 67380881 68501531 68552706 6608835 69101325 72953844 70821019 69048031 72633225 61140912 54073781 60322606 57650244 56386769 62697062 62198169 59570769 69290669 6023445 61606506 73056025 737557 68136712 374546 69969181 23338683 75174819 65188538 69799169 741522 74824906 32002778 54722069 7046925 7525465 71853394 73602806 68181975 65651312 75694525 75197531 74183694 63774731 71400575 69858831 77162369 63044931 67987769 78656056 67930625 74813744 80824094 7097245 73318544 71105756 56749119 596685 6300785 59486769 5678075 58693444 5718345 68402056 62974825 C13-label-1_Ornithine 3222038 3359478 3259616 308688 2827384 2884149 316952 2927472 2752465 3027933 289757 3164537 2819405 2276366 3291967 3469854 3259445 3052771 3371939 3272899 2890011 3137987 307228 3202903 2526501 3330595 3780171 3637136 2732446 3016065 317243 306897 3245138 2921524 2693858 3599989 3070718 3081269 3206628 3115037 2641097 3188313 2945038 361831 3234632 3249921 2850951 3075872 2809848 2644246 3533008 3272687 3027922 3110984 3882927 328065 326076 3385163 3432018 3506578 3585609 3397639 4142154 3770876 4386558 332217 3447304 3719959 3928112 3799375 3262571 4456126 3455545 3642612 3965795 371216 357296 3680388 3686411 3743838 3468716 2444388 3505345 3771966 3515715 3496305 3531687 3304553 3787367 3913568 4059646 3841617 4069623 3072495 2967226 3176312 3149712 3188628 3166548 3385263 3291955 378555 3496985 3231487 3934029 3623974 3551169 2036695 3730243 1226041 4092136 3439528 3800504 4127199 4013087 1734873 2757318 3867925 3898324 3596771 368829 3677495 3402198 4156409 4158116 3882672 3298393 382293 3835576 3696917 3404718 3549377 4124955 3731023 408482 4157088 373287 390948 3817988 2973715 332593 348415 3099529 3272619 3249095 3107815 3505717 3440891 C13-label-2_Ornithine 67882 0 0 53838 114442 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4477834 4826539 1896351 2271427 2471184 3309803 2568814 322227 2404893 49406825 20644033 24304792 38284072 19213683 27390709 39850725 245963 8809687 7913816 7575695 5257051 6939921 6745113 7143956 11310572 7543573 397115 4024054 3654006 2023828 192038 2298969 3935121 4126468 2740482 35367466 35522334 27501288 25429098 18749023 20309927 385923 24699917 2357947 895195 9615021 11768223 612029 6369453 865227 939142 8020363 1141716 17693992 20389314 1665985 1140579 14719247 13993633 15046545 17917062 15554477 32577959 33556778 35805772 2494138 2825285 17147145 32204266 32579497 34265772 38574878 31837762 33609159 30518772 28340209 35702962 28957547 357388 35970525 5895273 7400849 5064979 4581406 4842044 4290364 740324 7188121 5763092 10741123 9111906 122834 6253586 3392484 7812307 2509472 8446245 10240438 12472824 12229293 14217605 3476223 7728796 10476221 11291406 10936291 13333819 21386377 23490106 24105527 15278203 15720142 13686059 19372502 20144583 21571067 22400617 23909689 25694948 16051516 18044181 23787989 20510917 21408786 23205142 4007325 3930471 4145172 2474293 1967316 2395072 3355352 3821144 3649109 C13-label-1_Orotate 0 141568 12414 0 93751 114658 1018024 4766 553446 771774 853237 735277 869757 500595 463302 513327 144168 133231 141584 232559 228726 256175 2695281 4869643 2450734 2520618 2877557 1980178 2900117 4099434 3117885 746218 683386 662979 22067 356563 336815 515916 78478 654335 249301 398192 346015 82428 87228 0 325582 393707 104518 3389239 3545521 3162322 2282217 1553639 1780002 3220393 2245697 2334587 72929 686523 849484 408302 415911 47739 623568 48206 711902 996051 1257571 985307 659285 755721 695024 1035628 1269961 978568 2505233 2928711 325612 1837573 1938231 1474632 2871515 2522443 2774657 3173905 2946538 3121072 2197253 2327636 2488234 2363413 2900078 2966487 262425 540996 233546 191333 233239 133828 327281 41352 364303 651229 624456 825406 293702 123295 466635 174056 418093 64864 753223 734566 99579 115171 312512 642575 684201 353883 810605 1659536 173965 1507555 814017 930444 841239 132309 1405037 1456729 1994315 1883063 1923326 1475301 1481012 1531561 1714239 1727754 1808171 112564 267092 205465 216073 74713 104206 203724 172301 175891 C13-label-2_Orotate 0 0 0 0 1090781 1113954 916891 31912 326955 351492 89943 764754 793153 647579 600334 813713 0 0 0 447413 365267 304872 4300265 6889271 4217539 3176777 3360203 2334662 4303087 5092375 4683339 926719 1071922 7636 155684 330293 140845 558922 865329 551795 517488 551473 466709 0 73371 0 503898 468057 343403 4417134 5493536 4598558 2394004 1937137 2005441 4812529 2934067 3549242 386357 174627 438405 80344 0 111372 123042 119514 465597 762508 925549 523777 284448 305528 486813 451417 684003 446664 4354316 4609516 4362431 2192352 2465788 1359999 3721395 3703879 3918962 4377527 3568204 3458852 2363748 1955267 2641522 272376 348831 3608559 229352 128867 85679 0 82713 0 118164 251282 89064 295482 217832 512357 87431 0 97961 0 244934 149634 449325 500521 470693 0 91132 275016 276546 322544 278574 167166 1638221 1775816 818068 957377 660205 1580811 1412621 1320448 2034086 199947 2083131 112433 933637 1352062 1717603 1593135 1727292 0 0 0 0 0 0 0 0 0 C13-label-3_Orotate 0 0 0 0 689486 733271 63857 22092 177034 230337 521915 456784 60243 56826 29487 392984 0 0 134448 411508 97042 245487 3429386 5717314 3032337 2398065 3098354 1579557 3212038 4132339 3498073 442079 256764 445552 115416 262185 11152 23966 674435 40007 291414 432347 400747 0 0 82662 158962 118526 272309 3341424 3695814 2813028 1731561 1374778 1321508 3446377 2098216 2438085 1035038 1103217 1086234 416103 210669 80532 649214 777401 105334 733086 952873 907446 420191 646631 491842 760207 677044 686064 2284206 2617721 3127961 1595846 1640892 778489 2192366 2399321 237053 3047309 2404559 2387505 1976942 1454719 2021491 1828534 2287484 2662595 470991 349505 447311 157294 136234 215494 60045 594813 385075 885828 678134 891835 281044 22353 423855 88696 595396 75062 35651 5301 486287 0 102761 181711 495649 254401 338867 634103 700921 679612 321017 160074 209994 499151 556247 418979 1265873 1159825 1197271 874054 706986 833042 899968 768201 1079752 117522 151478 254586 1134 0 0 90363 11046 142525 C13-label-4_Orotate 0 0 0 0 11922 137767 94443 0 0 0 116111 0 0 0 0 131058 0 0 0 0 0 0 833452 1169325 803154 429386 439023 117299 643907 657327 755157 0 0 0 0 0 0 0 271939 0 0 10913 0 0 96629 75741 0 0 0 596381 831565 310911 281146 10968 9382 574063 427295 444675 0 0 112991 0 0 0 0 0 0 0 174879 0 0 0 0 0 0 0 430392 428936 554678 136651 115333 0 137106 267185 471763 748159 505631 664421 144246 108424 146389 428328 375712 460539 1057 0 0 128735 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 106991 367649 341289 0 0 0 110707 111156 0 0 0 126351 154064 0 89518 0 0 0 C12 PARENT_Phenylalanine 255339875 283727175 298956175 256258375 161422662 173290962 1725599 23641195 245388875 231903325 20095525 192790838 205495888 111612738 1624624 16550815 216215925 248534525 2803433 1627790 19268285 192453938 178119438 225201525 178648738 2711388 269688175 267252525 216577325 219122725 219310625 175026088 18824985 175910138 190054288 2830550 249808575 186967912 226249575 201714238 145839862 155732388 146904888 2289957 222633975 234830075 177483138 192575012 175196538 1839615 2040694 202107338 225137375 2356654 2935786 226392525 198749138 235605575 275299775 2834036 293039475 27565555 317303175 3092949 309746575 293997975 2986635 3060533 303300325 283770725 287945775 319008075 3049520 293369925 3112637 290512675 223063475 239860825 2356749 288490075 2975525 179043812 262604925 25310405 25109045 2437001 237779175 2365293 279974675 299578575 3121085 2560055 280914075 2552262 212215775 25739425 238684575 25060065 2768413 275701075 265908675 298953725 254213425 27902345 308163075 3005748 271794525 1550396 3056448 102550056 303191125 284661325 2882370 302985925 308122725 1452682 2519240 309223875 313353125 295954175 3129760 273592125 2844336 301919175 308508825 323127925 281074925 2838329 2920408 309265725 257822325 2770666 288045475 278871175 307199575 334247675 269807475 290028875 284954775 239437125 255409975 2623079 2350906 247521925 2624412 23350885 2889444 27663105 C13-label-1_Phenylalanine 25087523 27517781 29236878 24901252 155630 15992456 16972916 22516642 22988602 23374462 19529539 1980323 20036012 11010809 15443623 16518031 21532317 241217 28609834 16202211 18537198 18343211 17391531 22196023 18577117 26717575 27082309 26973066 21988836 20865061 2169915 17119517 18334388 17186198 18573514 30140634 24265525 17501519 20937373 18868852 14024364 14527156 14343717 22692467 2092447 24573433 17316481 1886093 17211417 18418155 19206914 18855636 22438048 236178 29038719 23398994 19497725 23112855 26429459 26515472 28235191 26942566 30536344 30377416 30011766 27817991 29469547 30210812 29462303 27827797 28089625 31154353 30138622 28731691 30066828 26712869 219552 23469256 22140538 26909359 29084959 17771058 25457098 24045425 24497167 23807314 22863123 22949975 26408916 28579244 30163806 24681389 27537147 2415138 21002912 24651898 24173919 23958206 27853584 27488422 25643112 29921831 25606117 26977891 30403703 285691 26400978 15102783 29160425 10405797 29039509 29016641 27534478 28783491 29230947 14780883 25462175 30201841 317816 28091453 30866228 26308094 25613636 30024416 29539559 32081941 26929059 26980038 27183391 28771153 24129733 27100412 28588797 26903034 29150475 33031012 2533145 28131062 271412 24205167 25607598 26443988 23570233 23735464 24205102 22938386 28557469 27206722 C13-label-2_Phenylalanine 941425 757353 1039952 866024 476796 788523 53179 775795 1061393 835031 770539 570545 804416 286421 571201 501123 866798 1016475 997893 400771 574149 671057 705242 749551 649206 1007472 1022235 860764 768802 83055 656363 608979 648739 567552 68812 1024641 814955 678699 1088363 718951 3391 550326 371744 795229 763329 837022 675322 679538 676631 619031 742839 66859 885471 834478 938176 767663 631315 74557 786196 863465 1035431 997568 108343 1070415 1009124 882395 942641 948114 90869 86845 1069161 1106521 1111902 1141157 997477 871604 671624 549125 843241 900837 82184 57171 870895 744604 78866 777194 793417 900455 729897 957967 1069267 804614 104488 907046 763796 1039557 783909 706072 1107616 533804 87596 916347 732611 76089 1043929 1042443 85569 506897 91808 28196 1115505 1056011 783388 1139037 1051749 377139 86676 1155678 1225323 873772 949563 948176 82214 91516 1122878 1157697 920239 1013217 968048 1041762 860676 1028609 1073576 97729 1079579 1099645 960092 871548 905388 860461 786143 927331 1049485 732565 875598 89048 762026 976662 C12 PARENT_Proline 192475488 214109025 253835975 191453912 24003385 26586245 23764735 228883925 253634525 224117375 25701335 258738625 249878025 171638538 207594512 2194866 19928575 217653975 239368975 191009462 1999551 201634638 166323688 21389535 166830912 230703225 218940425 229687625 19514835 1943949 1973771 2240007 2530478 2247656 19395305 2762750 234701425 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20349475 194535812 20237155 196311138 2483254 230239725 C13-label-1_Proline 10334947 11554479 14778838 10877245 14089061 14831055 14968888 12764006 14036948 12976882 1494808 13880638 13759602 11035837 11978465 13751889 10823252 12817702 12515865 10713291 12152607 11967922 9394363 11635852 10195941 1227539 12880793 12401956 10922123 11743469 10862479 13210642 13997498 12703441 10932796 15368095 1370452 12658818 1697072 137371 11576681 1302947 12450571 11991327 11138001 11354146 13202311 13578442 11820256 9141585 10098512 1192355 11161732 11247212 14165292 11928182 10279434 12379035 13418764 13565789 11944132 10402252 1252976 13091206 13089638 10879102 1313698 13516292 14353367 13830112 11624382 12397726 13117195 13216208 14405062 14035852 1193004 11939984 12794618 11316403 14443158 8927669 10685602 12818574 12166719 10402819 11319568 10385327 12751741 12005834 13190858 11801491 12333352 11279773 1099875 14550856 11369326 12406321 11855606 11335324 12813821 1301199 12890738 13067396 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21596902 26349484 30422088 32187262 30123516 10386712 10461263 11660207 12896291 15837339 9712115 126678 1229906 12512915 38283053 34920512 34790347 40727191 494238 57231606 38960325 42688391 45462903 1691715 21015838 18747305 18411031 21060595 19364481 24547492 27099828 21857898 50028903 45883734 46351847 30978378 20242838 35775603 16305095 42526059 48860816 25125312 24457045 25815562 8095219 16579241 1739913 25258944 2185585 24803192 7200979 8772123 8631793 7704566 8737516 7737996 824207 8125745 870503 28799375 32604956 27327422 21355617 24534519 28861059 27160325 29150147 28541259 14307558 15942477 15489734 1392008 11740612 12534816 14289417 17248795 16021647 C13-label-1_Pyruvate 124039 93016 332474 91145 726669 769308 6816629 4463805 5663832 4009718 7380804 6789455 7247648 2710044 3390141 3898511 275044 2865765 3279196 3069557 3366853 3371053 577495 7984338 6034353 5259073 4409311 5232518 6312977 574262 6897835 3361588 3554163 2987125 2304776 3096334 2937886 2743285 4132021 3212582 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2447484 C13-label-3_Pyruvate 173598 233772 168447 328016 383068725 42544255 3814284 245860075 2817714 218930475 4444266 403315075 42522415 16394755 181483112 215526175 104396281 9678145 110149662 1634688 156397362 169740112 2359566 301855875 250184025 164776338 156696588 17447905 239280325 236795175 262037975 193511912 212619175 190867762 118727888 1708057 154214662 18630905 2580446 205190162 134493038 137530938 138554312 75791206 74401619 83544831 13963605 1419250 1284051 195355688 243275125 257318025 107211112 115104188 162804088 204123812 174754638 22358625 195602038 196637312 19170165 71723169 79604581 99086675 15749985 150536338 172484838 124686225 136274412 126144162 43998562 56354562 62534575 94623869 104457969 9755385 400072 42462347 46954484 33994709 44023275 23910462 4049205 44361028 41546078 157248312 139549712 14991035 90435306 104622031 126034538 125681875 144762738 145032538 73682319 88017706 75443219 45945375 44415047 4199725 85921806 86472875 73448444 16752575 154119738 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210541475 1955425 234202225 2608462 272750875 2216277 2226862 211924125 113424212 1015996 119727362 200268362 22943385 138672738 1445175 152734162 146237212 1433959 148760488 136047262 218793125 2267910 259287325 171712338 175619738 18147475 121061938 1538479 140330938 196611462 2153336 211018575 18592025 2123093 177960112 12088665 13980044 125902 16729502 985756 17998205 4131689 14727514 13892092 11214499 11670949 102727 7534804 18081592 17655595 13388438 13549864 11562478 9566346 10579493 9727931 19492406 19663805 15390044 12065809 13581998 13374716 821659 10566812 11890288 15611262 17596064 20953558 11147469 13737056 1203677 7266461 8020977 7801652 1470195 132655 14062369 7720442 11576391 9189756 C13-label-3_Serine 0 0 111778 63215 23630998 27298809 25271819 16974509 20408302 16995803 27476712 25995367 26318278 16666262 25442933 28463628 13603078 14127017 177509 22383811 24523623 23550955 25847931 35570441 27354162 14645145 14451447 14869719 25455125 25302406 28698141 8486002 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979452 1737113 1475827 1674442 2062295 1176077 1623333 1476284 89431 1034883 1018012 1199117 112335 1137578 1229906 1331944 1162072 C13-label-2_Serine 13796 131376 249793 84933 7376465 7517425 7200279 3024609 3676914 3033588 7155104 7004378 6342017 4155401 6195809 706092 2379744 2356537 2835153 4891364 5434886 4873833 7582891 10518112 7894546 3940153 318489 3624082 743074 6772615 7527007 1058651 974034 972989 468983 64811 525303 661632 1242873 901495 102724 122661 100937 331557 238425 217443 126894 350537 132535 998861 148749 2089327 33194 31562 70028 1102967 953213 1408883 5825647 6210539 587565 1261013 1511752 1777358 4519708 3846869 4460323 3161616 4100357 3786835 644706 893012 8252 2009326 2851924 3117565 2397138 2620995 2808762 1142329 1838967 949445 1927821 2230169 2085274 4109474 4408594 3510574 163177 2016094 2503758 3486286 3607207 3301764 3450771 4798389 4142196 1397917 1405219 1030431 4443498 4516734 3269501 817195 105569 1129225 354851 104118 256104 184312 763391 1088672 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2696197 3051054 3022959 306516775 3343106 363812275 293797825 3114453 321924575 2487921 26711245 2895872 277900725 268002175 282440525 248893875 306900725 292362075 C13-label-1_Valine 15487005 17635058 19020161 15133178 9315134 10519897 10416722 13756303 13987417 14107588 121389 11079648 11086766 560338 7855498 8977355 12310275 15605092 16010809 8705116 9722016 9986362 10027435 13659583 9880963 16789598 1497575 17103817 12695912 12253098 12638006 10134203 11219562 10763423 1242063 17450695 1546917 10952328 13435936 11872916 6661018 7032891 6894501 13338205 12435123 13700773 9591018 9921204 8515249 10363073 12131491 11951177 131901 13310744 16314586 13329219 11994935 13762309 16949194 17188602 18713058 17605645 1983643 18143683 18147575 18383864 18973048 18641542 18428277 16512683 17121311 19380688 18797619 19640456 18668506 18657267 1418657 15688597 14312505 17939536 177555 11559809 16614655 15426112 14946186 15389614 14804558 15415206 16512381 17885645 19245095 15729052 16679158 15174775 12431144 15703303 13150031 15039211 16077602 15945014 162200 18382844 14791567 16009498 17984345 18743048 17511975 1041789 17701005 7447896 18802006 17698011 18298339 18997408 1890972 9179043 16646027 1989638 19417138 17721975 18923462 1631087 16450452 18835792 19731364 18976294 17644555 17759689 1788185 184036 15340112 16242562 16583384 17472102 18553258 19985611 15913814 17752438 18068155 13714759 15214975 16102088 15876352 15010875 15774931 14573402 16700606 16606406 C12 PARENT_Fumarate 17903319 19258277 27376784 16786164 31402541 32735147 29925197 24816912 28572925 23288544 32473472 28532866 29420666 28800588 29907825 37393603 24899138 27444697 29898125 27266375 26428425 28572903 22845412 32433784 23702269 27027638 24100755 26788553 25737483 24714964 26027181 27453428 31571359 28124959 25590992 33217609 26511622 25637395 40129772 28056534 29992203 31960316 29271528 23916323 23576588 24535805 33439725 31998038 28546684 2570272 31224809 34497866 20664161 21717417 29892722 29283953 2333832 29857466 263723 27989725 33718009 27338622 22179392 23064598 24602906 32668941 26433741 37437112 30288838 28050259 22175186 2389352 25835914 33986022 27286366 26437084 23857295 36576809 30039862 28653528 2614657 1776517 32991472 274705 26483778 35984928 26066789 37922238 22000527 22523548 26451356 24497656 32328053 28620478 25211744 29622319 26009406 25191067 2532965 24318298 31477103 35260191 26667103 2600847 24698348 26511284 19100248 1488502 21888095 16274542 24373792 26688328 35571225 27208122 28124716 18693362 23279838 318352 35665338 2581655 36768475 27452891 30737972 39772366 22227483 25703533 27862753 26969447 26376878 28198425 30827722 35352428 30742728 22811319 2450125 26740222 280392 29011762 39024225 26370697 28150666 28045141 26859862 20467855 21722488 21733611 31061425 28636438 C13-label-1_Fumarate 479535 367695 754954 499475 1700017 1825771 1318672 934266 937447 947993 1228132 1252887 1284698 1504784 1459318 1982929 940527 98235 1179743 1364707 1214998 115779 78849 1265462 880833 1008701 679736 74782 1121303 1108768 1069669 1180211 1234484 1257885 910025 1341543 959187 1079242 1526412 1136947 1443798 1249793 1490962 621191 763667 870281 1369765 1444238 1264337 1104078 1455296 1293648 708533 920338 1099249 1259345 806387 1124249 895622 1048661 139108 941223 758657 801556 775085 1356623 1055791 1661009 1065382 1068492 623724 873119 772414 1361374 979785 82212 947206 1653139 126541 1096588 890745 340159 155483 1059608 964715 157668 1124935 1722673 846637 849101 996656 1038187 1574341 1031867 855545 785451 870781 81812 757629 765632 106804 103546 921838 846579 894112 912632 633028 562376 671157 464379 8587 809863 1451819 982356 1249985 63236 769102 1216366 1296192 992421 1222991 1094154 1280191 1504135 93149 1056788 1160882 1156169 904473 934198 1600337 1684479 1651207 85315 1016418 930156 1261863 1135888 1778752 774592 837061 943167 1172517 649589 886805 778137 1113464 1059151 C13-label-2_Fumarate 0 0 0 0 1180112 1557948 1491983 224829 130127 357391 1132901 855045 998471 2309773 1814574 2419347 160132 14273 16367 1309834 1104303 1283492 648016 910826 795189 244546 0 113536 665887 577158 634008 925127 1033216 1032656 0 169449 317493 74378 833276 805154 1594313 1779975 1875357 194406 136331 397036 1218103 1306235 1179641 801648 9608 121342 89763 118496 331734 694183 479385 628087 116015 285308 184376 0 0 0 81399 0 224472 581942 588162 443865 86764 103555 0 400052 385253 258902 779268 1289822 1027411 98967 108004 0 676947 666208 612508 1721054 1257278 2106609 9609 1601 306244 614112 1055961 948737 566914 499041 347037 11989 89197 0 376362 368826 104554 111559 97206 150826 0 0 0 0 98174 102607 504326 383669 393299 0 0 0 209684 145732 278322 607092 617217 979854 333001 108578 12225 368791 435238 463272 1534277 1819841 17377 407174 318138 296384 996459 1076529 170351 230174 358931 237297 0 0 0 118774 164823 122912 C13-label-3_Fumarate 0 0 0 0 859084 899148 661914 177301 92476 122344 546718 561655 38815 1305389 1106002 1446956 107712 71431 170975 737942 590273 808715 609362 945081 657008 91589 9795 172338 50162 305441 516719 274341 375198 346415 91249 0 78166 424281 449864 295927 75897 957358 1110631 60146 96337 62388 513015 539355 619117 580789 804241 836654 64397 62727 92691 410391 423651 462508 332313 313879 704622 55598 0 0 213412 117738 264033 520442 35351 248175 0 0 69409 244314 282362 254389 456548 824895 490508 52434 0 0 34027 196848 199389 1263678 658761 1179963 233586 15559 174541 508808 668701 579008 69401 551588 583934 87749 63712 8472 590214 653206 376669 234627 72156 27945 0 0 0 0 83228 808 403773 324731 224382 0 0 59875 275588 10576 312114 282836 153276 105727 0 0 0 58445 0 65982 785792 894663 917258 80081 116032 87459 492244 575584 720903 481604 427224 443984 103893 99793 0 278842 325599 395657 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name medMz medRt C12 PARENT_2-Hydroxybutyric acid 103.040092 3.405 C13-label-1_2-Hydroxybutyric acid 104.043716 3.425 C12 PARENT_3-Hydroxybutyrate 103.040054 4.243 C13-label-1_3-Hydroxybutyrate 104.043526 4.193 C12 PARENT_Alanine 88.040276 6.492 C13-label-2_Alanine 90.047005 6.508 C13-label-3_Alanine 91.050552 6.504 C13-label-1_Alanine 89.043831 6.496 C12 PARENT_Aconitate 173.009308 10.146 C13-label-1_Aconitate 174.012329 10.147 C13-label-2_Aconitate 175.015762 10.162 C13-label-4_Aconitate 177.022659 10.162 C13-label-5_Aconitate 178.026031 10.154 C13-label-6_Aconitate 179.029449 10.154 C13-label-1_Arginine 174.107483 10.121 C13-label-2_Arginine 175.111374 10.114 C12 PARENT_Arginine 173.104095 10.11 C12 PARENT_Asparagine 131.046219 7.658 C13-label-1_Asparagine 132.04953 7.644 C13-label-2_Asparagine 133.052734 7.65 C12 PARENT_Aspartate 132.03009 8.933 C13-label-1_Aspartate 133.033386 8.921 C13-label-2_Aspartate 134.036774 8.926 C13-label-3_Aspartate 135.040146 8.935 C12 PARENT_Citrate 191.019608 11.39 C13-label-1_Citrate 192.023331 11.45 C13-label-2_Citrate 193.026413 11.796 C13-label-3_Citrate 194.029709 11.428 C13-label-4_Citrate 195.033234 11.329 C13-label-5_Citrate 196.036606 11.404 C13-label-2_Isocitrate 193.026611 10.429 C13-label-3_Isocitrate 194.029602 10.431 C13-label-4_Isocitrate 195.033218 10.442 C13-label-5_Isocitrate 196.03656 10.44 C12 PARENT_Isocitrate 191.019592 10.387 C13-label-1_Isocitrate 192.023346 10.405 C12 PARENT_Citrulline 174.088196 7.921 C13-label-1_Citrulline 175.091782 7.921 C12 PARENT_Creatine 130.062256 6.459 C13-label-1_Creatine 131.065872 6.504 C12 PARENT_Creatine phosphate 210.028809 10.215 C13-label-4_Creatine phosphate 214.043747 10.276 C12 PARENT_Cystine 239.016678 9.897 C13-label-1_Cystine 240.019943 9.915 C13-label-2_Cystine 241.02124 9.957 C12 PARENT_Cytidine 242.077942 3.933 C13-label-1_Cytidine 243.081238 3.921 C13-label-2_Cytidine 244.082596 3.962 C13-label-5_Cytidine 247.095261 3.954 C12 PARENT_Glucose 179.056244 5.845 C13-label-1_Glucose 180.059891 5.825 C13-label-3_Glucose 182.06633 5.842 C13-label-4_Glucose 183.069794 5.854 C13-label-5_Glucose 184.072525 5.849 C13-label-6_Glucose 185.076157 5.846 C12 PARENT_N-carbamoyl-aspartate 175.036362 9.508 C13-label-1_N-carbamoyl-aspartate 176.039902 9.484 C13-label-3_N-carbamoyl-aspartate 178.044891 9.496 C13-label-5_N-carbamoyl-aspartate 180.052826 9.565 C12 PARENT_Glutamate 146.045639 8.787 C13-label-1_Glutamate 147.048965 8.786 C13-label-2_Glutamate 148.052658 8.792 C13-label-3_Glutamate 149.055252 8.789 C13-label-4_Glutamate 150.059143 8.789 C13-label-5_Glutamate 151.061768 8.826 C12 PARENT_Glutamine 145.061905 7.369 C13-label-1_Glutamine 146.065033 7.38 C13-label-2_Glutamine 147.068405 7.384 C13-label-4_Glutamine 149.075287 7.388 C13-label-5_Glutamine 150.078537 7.433 C12 PARENT_Glycerate 105.019485 5.024 C13-label-1_Glycerate 106.022652 5.892 C13-label-2_Glycerate 107.025116 4.782 C12 PARENT_Glycerate_2nd Peak 105.019493 5.912 C13-label-1_Glycerate_2nd Peak 106.022659 5.894 C13-label-3_Glycerate_2nd Peak 108.03 5.9 C12 PARENT_Glycine 74.02 6.99 C13-label-1_Glycine 75.03 7.02 C13-label-2_Glycine 76.03 6.99 C12 PARENT_Leucine 130.08728 3.919 C13-label-1_Leucine 131.090576 3.914 C13-label-2_Leucine 132.093872 3.92 C12 PARENT_Isoleucine 130.087265 4.321 C13-label-1_Isoleucine 131.090546 4.323 C13-label-2_Isoleucine 132.093826 4.306 C12 PARENT_Inositol 179.056244 8.293 C13-label-1_Inositol 180.059326 8.291 C12 PARENT_Lactate 89.024414 4.258 C13-label-1_Lactate 90.027626 4.258 C13-label-2_Lactate 91.031235 4.272 C13-label-3_Lactate 92.034401 4.263 C12 PARENT_Lysine 145.09819 10.737 C13-label-1_Lysine 146.101562 10.737 C13-label-2_Lysine 147.105103 10.777 C12 PARENT_Malate 133.014267 9.166 C13-label-1_Malate 134.017578 9.194 C13-label-2_Malate 135.020889 9.206 C13-label-3_Malate 136.0242 9.195 C13-label-4_Malate 137.027374 9.297 C12 PARENT_Methionine 148.043579 4.552 C13-label-1_Methionine 149.046814 4.554 C13-label-4_Methionine 152.057266 4.578 C12 PARENT_Ornithine 131.082489 10.121 C13-label-1_Ornithine 132.085953 10.114 C13-label-2_Ornithine 133.089249 10.473 C12 PARENT_Orotate 155.009781 4.048 C13-label-1_Orotate 156.013016 4.063 C13-label-2_Orotate 157.016754 4.044 C13-label-3_Orotate 158.019836 4.052 C13-label-4_Orotate 159.023529 4.027 C12 PARENT_Phenylalanine 164.071762 3.598 C13-label-1_Phenylalanine 165.074753 3.588 C13-label-2_Phenylalanine 166.078384 3.582 C12 PARENT_Proline 114.055962 5.654 C13-label-1_Proline 115.059471 5.649 C13-label-2_Proline 116.062683 5.652 C13-label-3_Proline 117.066231 5.663 C13-label-4_Proline 118.069489 5.663 C13-label-5_Proline 119.072861 5.674 C12 PARENT_Pyridoxine 168.066467 2.299 C13-label-1_Pyridoxine 169.07019 2.299 C13-label-2_Pyridoxine 170.073807 2.299 C12 PARENT_Pyruvate 87.008781 2.754 C13-label-1_Pyruvate 88.011986 2.754 C13-label-2_Pyruvate 89.015564 2.755 C13-label-3_Pyruvate 90.018776 2.755 C12 PARENT_Serine 104.035347 7.518 C13-label-3_Serine 107.045647 7.522 C13-label-1_Serine 105.038437 7.579 C13-label-2_Serine 106.04184 7.621 C12 PARENT_Taurine 124.007324 5.814 C13-label-1_Taurine 125.010719 5.457 C12 PARENT_Threonine 118.050957 6.814 C13-label-1_Threonine 119.054489 6.804 C13-label-2_Threonine 120.056664 6.494 C12 PARENT_Tryptophan 203.082443 3.41 C13-label-1_Tryptophan 204.086029 3.414 C13-label-8_Tryptophan 211.109024 3.482 C12 PARENT_Tyrosine 180.066467 5.034 C13-label-1_Tyrosine 181.071884 5.758 C13-label-2_Tyrosine 182.073822 5.048 C13-label-3_Tyrosine 183.076096 5.765 C13-label-4_Tyrosine 184.080063 5.137 C12 PARENT_Uracil 111.020248 2.118 C13-label-1_Uracil 112.023438 2.123 C13-label-2_Uracil 113.026482 2.148 C13-label-3_Uracil 114.030838 2.174 C12 PARENT_Valine 116.0718 5.367 C13-label-1_Valine 117.075165 5.368 C12 PARENT_Fumarate 115.003868 8.412 C13-label-1_Fumarate 116.007111 8.408 C13-label-2_Fumarate 117.010612 8.403 C13-label-3_Fumarate 118.013855 8.408 METABOLITES_END #END