#METABOLOMICS WORKBENCH juliehaines_20250529_112226 DATATRACK_ID:5964 STUDY_ID:ST003937 ANALYSIS_ID:AN006466 PROJECT_ID:PR002467
VERSION             	1
CREATED_ON             	June 4, 2025, 10:43 am
#PROJECT
PR:PROJECT_TITLE                 	Post-transfusion recovery, quality and metabolism of short and long-term stored
PR:PROJECT_TITLE                 	platelets during controlled inflammation
PR:PROJECT_SUMMARY               	Platelet concentrates (PCs) are frequently used to prevent and treat bleeding in
PR:PROJECT_SUMMARY               	patients. However, their efficacy is reduced during inflammation as well as due
PR:PROJECT_SUMMARY               	to platelet storage lesion, including metabolomic shifts and changes in surface
PR:PROJECT_SUMMARY               	markers of stored PCs. This study aims to identify disparities between
PR:PROJECT_SUMMARY               	short-term and long-term stored PCs during controlled inflammation, focusing on
PR:PROJECT_SUMMARY               	distinct metabolic pathways, alterations in surface markers and post-transfusion
PR:PROJECT_SUMMARY               	recovery (PTR). Twenty-four male subjects received lipopolysaccharide (LPS) or
PR:PROJECT_SUMMARY               	saline as control following an autologous transfusion of either short-term (2
PR:PROJECT_SUMMARY               	days stored) or long-term stored (7 days stored) PCs. Metabolomics and surface
PR:PROJECT_SUMMARY               	markers of these transfused PCs were assessed before transfusion using mass
PR:PROJECT_SUMMARY               	spectrometry and flow cytometry, respectively. Biotin-labeled platelets were
PR:PROJECT_SUMMARY               	used to assess surface markers after transfusion and determine PTR. Prior to
PR:PROJECT_SUMMARY               	transfusion, short-term stored PCs demonstrated increased glycolysis, pentose
PR:PROJECT_SUMMARY               	phosphate pathway activity, dense granule components (e.g., serotonine,
PR:PROJECT_SUMMARY               	adenosine diphosphate, epinephrine), and purine, arginine, and tryptophan
PR:PROJECT_SUMMARY               	metabolism. In contrast, long-term stored PCs exhibited elevated
PR:PROJECT_SUMMARY               	transsulfuration and taurine metabolism, along with higher levels of CD62P and
PR:PROJECT_SUMMARY               	CD63. During inflammation, a decreased PTR was found, particularly in long-term
PR:PROJECT_SUMMARY               	stored PCs. Higher expression of signaling molecules and lower CD62P and lactate
PR:PROJECT_SUMMARY               	levels were correlated with improved PTR. Differences in metabolic pathways,
PR:PROJECT_SUMMARY               	surface markers, and PTR were identified between short-term and long-term stored
PR:PROJECT_SUMMARY               	PCs in a controlled human experiment – suggesting a preference for the use of
PR:PROJECT_SUMMARY               	short-term stored PCs during inflammation. This trial was registered at
PR:PROJECT_SUMMARY               	https://trialsearch.who.int/ as #NL-OMON26852.
PR:INSTITUTE                     	University of Colorado Anschutz Medical Campus
PR:LABORATORY                    	Angelo D'Alessandro in collaboration with Alexander P.J. Vlaar (University of
PR:LABORATORY                    	Amsterdam)
PR:LAST_NAME                     	Haines
PR:FIRST_NAME                    	Julie
PR:ADDRESS                       	12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA
PR:EMAIL                         	julie.haines@cuanschutz.edu
PR:PHONE                         	3037243339
#STUDY
ST:STUDY_TITLE                   	Post-transfusion recovery, quality and metabolism of short and long-term stored
ST:STUDY_TITLE                   	platelets during controlled inflammation
ST:STUDY_SUMMARY                 	Metabolomics data of fresh and stored platelets sampled longitudinally with or
ST:STUDY_SUMMARY                 	without lipopolysaccharide (LPS) treatment. This study is part of a larger study
ST:STUDY_SUMMARY                 	on the influence of storage time of platelet concentrates in a two-hit healthy
ST:STUDY_SUMMARY                 	volunteer model on transfusion-related acute lung injury; the results of this
ST:STUDY_SUMMARY                 	study must therefore be considered exploratory [Transfusion.
ST:STUDY_SUMMARY                 	2022;62(12):2490-2501.]. Short-term stored platelet concentrates showed
ST:STUDY_SUMMARY                 	increased glycolysis, pentose phosphate pathway, signaling molecules, and
ST:STUDY_SUMMARY                 	purine, arginine, and tryptophan metabolism, while long-term stored platelet
ST:STUDY_SUMMARY                 	concentrates had elevated transsulfuration and taurine metabolism. Lower lactate
ST:STUDY_SUMMARY                 	levels were linked to improved post-transfusion recovery.
ST:INSTITUTE                     	University of Colorado Anschutz Medical Campus
ST:LAST_NAME                     	Haines
ST:FIRST_NAME                    	Julie
ST:ADDRESS                       	12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA
ST:EMAIL                         	julie.haines@cuanschutz.edu
ST:PHONE                         	3037243339
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:AGE_OR_AGE_RANGE              	18-35
SU:GENDER                        	Male
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	1001	AA36-1	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-1
SUBJECT_SAMPLE_FACTORS           	1001	AA36-2	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-2
SUBJECT_SAMPLE_FACTORS           	1001	AA36-3	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-3
SUBJECT_SAMPLE_FACTORS           	1001	AA36-4	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-4
SUBJECT_SAMPLE_FACTORS           	1001	AA36-5	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-5
SUBJECT_SAMPLE_FACTORS           	1001	AA36-6	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-6
SUBJECT_SAMPLE_FACTORS           	1001	AA36-7	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-7
SUBJECT_SAMPLE_FACTORS           	1001	AA36-8	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-8
SUBJECT_SAMPLE_FACTORS           	1001	AA36-9	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-9
SUBJECT_SAMPLE_FACTORS           	1001	AA36-10	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-10
SUBJECT_SAMPLE_FACTORS           	1003	AA36-11	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-11
SUBJECT_SAMPLE_FACTORS           	1003	AA36-12	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-12
SUBJECT_SAMPLE_FACTORS           	1003	AA36-13	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-13
SUBJECT_SAMPLE_FACTORS           	1003	AA36-14	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-14
SUBJECT_SAMPLE_FACTORS           	1003	AA36-15	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-15
SUBJECT_SAMPLE_FACTORS           	1003	AA36-16	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-16
SUBJECT_SAMPLE_FACTORS           	1003	AA36-17	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-17
SUBJECT_SAMPLE_FACTORS           	1003	AA36-18	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-18
SUBJECT_SAMPLE_FACTORS           	1003	AA36-19	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-19
SUBJECT_SAMPLE_FACTORS           	1003	AA36-20	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-20
SUBJECT_SAMPLE_FACTORS           	1004	AA36-21	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-21
SUBJECT_SAMPLE_FACTORS           	1004	AA36-22	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-22
SUBJECT_SAMPLE_FACTORS           	1004	AA36-23	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-23
SUBJECT_SAMPLE_FACTORS           	1004	AA36-24	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-24
SUBJECT_SAMPLE_FACTORS           	1004	AA36-25	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-25
SUBJECT_SAMPLE_FACTORS           	1004	AA36-26	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-26
SUBJECT_SAMPLE_FACTORS           	1004	AA36-27	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-27
SUBJECT_SAMPLE_FACTORS           	1004	AA36-28	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-28
SUBJECT_SAMPLE_FACTORS           	1004	AA36-29	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-29
SUBJECT_SAMPLE_FACTORS           	1004	AA36-30	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-30
SUBJECT_SAMPLE_FACTORS           	1005	AA36-31	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-31
SUBJECT_SAMPLE_FACTORS           	1005	AA36-32	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-32
SUBJECT_SAMPLE_FACTORS           	1005	AA36-33	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-33
SUBJECT_SAMPLE_FACTORS           	1005	AA36-34	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-34
SUBJECT_SAMPLE_FACTORS           	1005	AA36-35	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-35
SUBJECT_SAMPLE_FACTORS           	1005	AA36-36	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-36
SUBJECT_SAMPLE_FACTORS           	1005	AA36-37	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-37
SUBJECT_SAMPLE_FACTORS           	1005	AA36-38	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-38
SUBJECT_SAMPLE_FACTORS           	1005	AA36-39	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-39
SUBJECT_SAMPLE_FACTORS           	1005	AA36-40	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-40
SUBJECT_SAMPLE_FACTORS           	1006	AA36-41	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-41
SUBJECT_SAMPLE_FACTORS           	1006	AA36-42	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-42
SUBJECT_SAMPLE_FACTORS           	1006	AA36-43	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-43
SUBJECT_SAMPLE_FACTORS           	1006	AA36-44	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-44
SUBJECT_SAMPLE_FACTORS           	1006	AA36-45	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-45
SUBJECT_SAMPLE_FACTORS           	1006	AA36-46	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-46
SUBJECT_SAMPLE_FACTORS           	1006	AA36-47	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-47
SUBJECT_SAMPLE_FACTORS           	1006	AA36-48	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-48
SUBJECT_SAMPLE_FACTORS           	1006	AA36-49	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-49
SUBJECT_SAMPLE_FACTORS           	1006	AA36-50	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-50
SUBJECT_SAMPLE_FACTORS           	1007	AA36-51	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-51
SUBJECT_SAMPLE_FACTORS           	1007	AA36-52	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-52
SUBJECT_SAMPLE_FACTORS           	1007	AA36-53	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-53
SUBJECT_SAMPLE_FACTORS           	1007	AA36-54	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-54
SUBJECT_SAMPLE_FACTORS           	1007	AA36-55	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-55
SUBJECT_SAMPLE_FACTORS           	1007	AA36-56	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-56
SUBJECT_SAMPLE_FACTORS           	1007	AA36-57	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-57
SUBJECT_SAMPLE_FACTORS           	1007	AA36-58	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-58
SUBJECT_SAMPLE_FACTORS           	1007	AA36-59	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-59
SUBJECT_SAMPLE_FACTORS           	1007	AA36-60	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-60
SUBJECT_SAMPLE_FACTORS           	1011	AA36-61	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-61
SUBJECT_SAMPLE_FACTORS           	1011	AA36-62	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-62
SUBJECT_SAMPLE_FACTORS           	1011	AA36-63	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-63
SUBJECT_SAMPLE_FACTORS           	1011	AA36-64	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-64
SUBJECT_SAMPLE_FACTORS           	1011	AA36-65	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-65
SUBJECT_SAMPLE_FACTORS           	1011	AA36-66	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-66
SUBJECT_SAMPLE_FACTORS           	1011	AA36-67	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-67
SUBJECT_SAMPLE_FACTORS           	1011	AA36-68	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-68
SUBJECT_SAMPLE_FACTORS           	1011	AA36-69	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-69
SUBJECT_SAMPLE_FACTORS           	1011	AA36-70	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-70
SUBJECT_SAMPLE_FACTORS           	1012	AA36-71	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-71
SUBJECT_SAMPLE_FACTORS           	1012	AA36-72	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-72
SUBJECT_SAMPLE_FACTORS           	1012	AA36-73	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-73
SUBJECT_SAMPLE_FACTORS           	1012	AA36-74	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-74
SUBJECT_SAMPLE_FACTORS           	1012	AA36-75	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-75
SUBJECT_SAMPLE_FACTORS           	1012	AA36-76	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-76
SUBJECT_SAMPLE_FACTORS           	1012	AA36-77	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-77
SUBJECT_SAMPLE_FACTORS           	1012	AA36-78	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-78
SUBJECT_SAMPLE_FACTORS           	1012	AA36-79	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-79
SUBJECT_SAMPLE_FACTORS           	1012	AA36-80	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-80
SUBJECT_SAMPLE_FACTORS           	1013	AA36-81	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-81
SUBJECT_SAMPLE_FACTORS           	1013	AA36-82	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-82
SUBJECT_SAMPLE_FACTORS           	1013	AA36-83	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-83
SUBJECT_SAMPLE_FACTORS           	1013	AA36-84	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-84
SUBJECT_SAMPLE_FACTORS           	1013	AA36-85	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-85
SUBJECT_SAMPLE_FACTORS           	1013	AA36-86	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-86
SUBJECT_SAMPLE_FACTORS           	1013	AA36-87	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-87
SUBJECT_SAMPLE_FACTORS           	1013	AA36-88	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-88
SUBJECT_SAMPLE_FACTORS           	1013	AA36-89	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-89
SUBJECT_SAMPLE_FACTORS           	1013	AA36-90	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-90
SUBJECT_SAMPLE_FACTORS           	1015	AA36-91	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-91
SUBJECT_SAMPLE_FACTORS           	1015	AA36-92	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-92
SUBJECT_SAMPLE_FACTORS           	1015	AA36-93	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-93
SUBJECT_SAMPLE_FACTORS           	1015	AA36-94	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-94
SUBJECT_SAMPLE_FACTORS           	1015	AA36-95	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-95
SUBJECT_SAMPLE_FACTORS           	1015	AA36-96	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-96
SUBJECT_SAMPLE_FACTORS           	1015	AA36-97	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-97
SUBJECT_SAMPLE_FACTORS           	1015	AA36-98	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-98
SUBJECT_SAMPLE_FACTORS           	1015	AA36-99	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-99
SUBJECT_SAMPLE_FACTORS           	1015	AA36-100	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-100
SUBJECT_SAMPLE_FACTORS           	1016	AA36-101	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-101
SUBJECT_SAMPLE_FACTORS           	1016	AA36-102	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-102
SUBJECT_SAMPLE_FACTORS           	1016	AA36-103	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-103
SUBJECT_SAMPLE_FACTORS           	1016	AA36-104	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-104
SUBJECT_SAMPLE_FACTORS           	1016	AA36-105	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-105
SUBJECT_SAMPLE_FACTORS           	1016	AA36-106	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-106
SUBJECT_SAMPLE_FACTORS           	1016	AA36-107	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-107
SUBJECT_SAMPLE_FACTORS           	1016	AA36-108	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-108
SUBJECT_SAMPLE_FACTORS           	1016	AA36-109	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-109
SUBJECT_SAMPLE_FACTORS           	1016	AA36-110	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-110
SUBJECT_SAMPLE_FACTORS           	1017	AA36-111	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-111
SUBJECT_SAMPLE_FACTORS           	1017	AA36-112	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-112
SUBJECT_SAMPLE_FACTORS           	1017	AA36-113	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-113
SUBJECT_SAMPLE_FACTORS           	1017	AA36-114	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-114
SUBJECT_SAMPLE_FACTORS           	1017	AA36-115	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-115
SUBJECT_SAMPLE_FACTORS           	1017	AA36-116	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-116
SUBJECT_SAMPLE_FACTORS           	1017	AA36-117	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-117
SUBJECT_SAMPLE_FACTORS           	1017	AA36-118	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-118
SUBJECT_SAMPLE_FACTORS           	1017	AA36-119	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-119
SUBJECT_SAMPLE_FACTORS           	1017	AA36-120	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-120
SUBJECT_SAMPLE_FACTORS           	1019	AA36-121	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-121
SUBJECT_SAMPLE_FACTORS           	1019	AA36-122	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-122
SUBJECT_SAMPLE_FACTORS           	1019	AA36-123	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-123
SUBJECT_SAMPLE_FACTORS           	1019	AA36-124	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-124
SUBJECT_SAMPLE_FACTORS           	1019	AA36-125	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-125
SUBJECT_SAMPLE_FACTORS           	1019	AA36-126	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-126
SUBJECT_SAMPLE_FACTORS           	1019	AA36-127	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-127
SUBJECT_SAMPLE_FACTORS           	1019	AA36-128	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-128
SUBJECT_SAMPLE_FACTORS           	1019	AA36-129	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-129
SUBJECT_SAMPLE_FACTORS           	1019	AA36-130	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-130
SUBJECT_SAMPLE_FACTORS           	1021	AA36-131	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-131
SUBJECT_SAMPLE_FACTORS           	1021	AA36-132	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-132
SUBJECT_SAMPLE_FACTORS           	1021	AA36-133	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-133
SUBJECT_SAMPLE_FACTORS           	1021	AA36-134	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-134
SUBJECT_SAMPLE_FACTORS           	1021	AA36-135	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-135
SUBJECT_SAMPLE_FACTORS           	1021	AA36-136	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-136
SUBJECT_SAMPLE_FACTORS           	1021	AA36-137	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-137
SUBJECT_SAMPLE_FACTORS           	1021	AA36-138	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-138
SUBJECT_SAMPLE_FACTORS           	1021	AA36-139	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-139
SUBJECT_SAMPLE_FACTORS           	1021	AA36-140	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-140
SUBJECT_SAMPLE_FACTORS           	1022	AA36-141	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-141
SUBJECT_SAMPLE_FACTORS           	1022	AA36-142	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-142
SUBJECT_SAMPLE_FACTORS           	1022	AA36-143	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-143
SUBJECT_SAMPLE_FACTORS           	1022	AA36-144	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-144
SUBJECT_SAMPLE_FACTORS           	1022	AA36-145	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-145
SUBJECT_SAMPLE_FACTORS           	1022	AA36-146	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-146
SUBJECT_SAMPLE_FACTORS           	1022	AA36-147	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-147
SUBJECT_SAMPLE_FACTORS           	1022	AA36-148	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-148
SUBJECT_SAMPLE_FACTORS           	1022	AA36-149	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-149
SUBJECT_SAMPLE_FACTORS           	1022	AA36-150	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-150
SUBJECT_SAMPLE_FACTORS           	1023	AA36-151	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-151
SUBJECT_SAMPLE_FACTORS           	1023	AA36-152	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-152
SUBJECT_SAMPLE_FACTORS           	1023	AA36-153	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-153
SUBJECT_SAMPLE_FACTORS           	1023	AA36-154	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-154
SUBJECT_SAMPLE_FACTORS           	1023	AA36-155	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-155
SUBJECT_SAMPLE_FACTORS           	1023	AA36-156	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-156
SUBJECT_SAMPLE_FACTORS           	1023	AA36-157	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-157
SUBJECT_SAMPLE_FACTORS           	1023	AA36-158	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-158
SUBJECT_SAMPLE_FACTORS           	1023	AA36-159	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-159
SUBJECT_SAMPLE_FACTORS           	1023	AA36-160	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-160
SUBJECT_SAMPLE_FACTORS           	1024	AA36-161	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-161
SUBJECT_SAMPLE_FACTORS           	1024	AA36-162	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-162
SUBJECT_SAMPLE_FACTORS           	1024	AA36-163	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-163
SUBJECT_SAMPLE_FACTORS           	1024	AA36-164	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-164
SUBJECT_SAMPLE_FACTORS           	1024	AA36-165	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-165
SUBJECT_SAMPLE_FACTORS           	1024	AA36-166	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-166
SUBJECT_SAMPLE_FACTORS           	1024	AA36-167	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-167
SUBJECT_SAMPLE_FACTORS           	1024	AA36-168	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-168
SUBJECT_SAMPLE_FACTORS           	1024	AA36-169	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-169
SUBJECT_SAMPLE_FACTORS           	1024	AA36-170	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-170
SUBJECT_SAMPLE_FACTORS           	1025	AA36-171	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-171
SUBJECT_SAMPLE_FACTORS           	1025	AA36-172	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-172
SUBJECT_SAMPLE_FACTORS           	1025	AA36-173	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-173
SUBJECT_SAMPLE_FACTORS           	1025	AA36-174	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-174
SUBJECT_SAMPLE_FACTORS           	1025	AA36-175	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-175
SUBJECT_SAMPLE_FACTORS           	1025	AA36-176	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-176
SUBJECT_SAMPLE_FACTORS           	1025	AA36-177	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-177
SUBJECT_SAMPLE_FACTORS           	1025	AA36-178	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-178
SUBJECT_SAMPLE_FACTORS           	1025	AA36-179	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-179
SUBJECT_SAMPLE_FACTORS           	1025	AA36-180	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-180
SUBJECT_SAMPLE_FACTORS           	1029	AA36-181	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-181
SUBJECT_SAMPLE_FACTORS           	1029	AA36-182	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-182
SUBJECT_SAMPLE_FACTORS           	1029	AA36-183	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-183
SUBJECT_SAMPLE_FACTORS           	1029	AA36-184	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-184
SUBJECT_SAMPLE_FACTORS           	1029	AA36-185	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-185
SUBJECT_SAMPLE_FACTORS           	1029	AA36-186	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-186
SUBJECT_SAMPLE_FACTORS           	1029	AA36-187	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-187
SUBJECT_SAMPLE_FACTORS           	1029	AA36-188	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-188
SUBJECT_SAMPLE_FACTORS           	1029	AA36-189	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-189
SUBJECT_SAMPLE_FACTORS           	1029	AA36-190	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-190
SUBJECT_SAMPLE_FACTORS           	1030	AA36-191	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-191
SUBJECT_SAMPLE_FACTORS           	1030	AA36-192	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-192
SUBJECT_SAMPLE_FACTORS           	1030	AA36-193	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-193
SUBJECT_SAMPLE_FACTORS           	1030	AA36-194	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-194
SUBJECT_SAMPLE_FACTORS           	1030	AA36-195	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-195
SUBJECT_SAMPLE_FACTORS           	1030	AA36-196	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-196
SUBJECT_SAMPLE_FACTORS           	1030	AA36-197	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-197
SUBJECT_SAMPLE_FACTORS           	1030	AA36-198	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-198
SUBJECT_SAMPLE_FACTORS           	1030	AA36-199	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-199
SUBJECT_SAMPLE_FACTORS           	1030	AA36-200	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-200
SUBJECT_SAMPLE_FACTORS           	1031	AA36-201	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-201
SUBJECT_SAMPLE_FACTORS           	1031	AA36-202	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-202
SUBJECT_SAMPLE_FACTORS           	1031	AA36-203	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-203
SUBJECT_SAMPLE_FACTORS           	1031	AA36-204	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-204
SUBJECT_SAMPLE_FACTORS           	1031	AA36-205	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-205
SUBJECT_SAMPLE_FACTORS           	1031	AA36-206	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-206
SUBJECT_SAMPLE_FACTORS           	1031	AA36-207	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-207
SUBJECT_SAMPLE_FACTORS           	1031	AA36-208	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-208
SUBJECT_SAMPLE_FACTORS           	1031	AA36-209	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-209
SUBJECT_SAMPLE_FACTORS           	1031	AA36-210	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-210
SUBJECT_SAMPLE_FACTORS           	1033	AA36-211	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-211
SUBJECT_SAMPLE_FACTORS           	1033	AA36-212	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-212
SUBJECT_SAMPLE_FACTORS           	1033	AA36-213	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-213
SUBJECT_SAMPLE_FACTORS           	1033	AA36-214	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-214
SUBJECT_SAMPLE_FACTORS           	1033	AA36-215	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-215
SUBJECT_SAMPLE_FACTORS           	1033	AA36-216	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-216
SUBJECT_SAMPLE_FACTORS           	1033	AA36-217	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-217
SUBJECT_SAMPLE_FACTORS           	1033	AA36-218	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-218
SUBJECT_SAMPLE_FACTORS           	1033	AA36-219	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-219
SUBJECT_SAMPLE_FACTORS           	1033	AA36-220	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-220
SUBJECT_SAMPLE_FACTORS           	1034	AA36-221	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-221
SUBJECT_SAMPLE_FACTORS           	1034	AA36-222	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-222
SUBJECT_SAMPLE_FACTORS           	1034	AA36-223	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-223
SUBJECT_SAMPLE_FACTORS           	1034	AA36-224	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-224
SUBJECT_SAMPLE_FACTORS           	1034	AA36-225	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-225
SUBJECT_SAMPLE_FACTORS           	1034	AA36-226	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-226
SUBJECT_SAMPLE_FACTORS           	1034	AA36-227	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-227
SUBJECT_SAMPLE_FACTORS           	1034	AA36-228	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-228
SUBJECT_SAMPLE_FACTORS           	1034	AA36-229	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-229
SUBJECT_SAMPLE_FACTORS           	1034	AA36-230	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-230
SUBJECT_SAMPLE_FACTORS           	1035	AA36-231	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-231
SUBJECT_SAMPLE_FACTORS           	1035	AA36-232	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-232
SUBJECT_SAMPLE_FACTORS           	1035	AA36-233	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-233
SUBJECT_SAMPLE_FACTORS           	1035	AA36-234	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-234
SUBJECT_SAMPLE_FACTORS           	1035	AA36-235	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-235
SUBJECT_SAMPLE_FACTORS           	1035	AA36-236	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-236
SUBJECT_SAMPLE_FACTORS           	1035	AA36-237	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-237
SUBJECT_SAMPLE_FACTORS           	1035	AA36-238	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-238
SUBJECT_SAMPLE_FACTORS           	1035	AA36-239	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-239
SUBJECT_SAMPLE_FACTORS           	1035	AA36-240	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	RAW_FILE_NAME(Notebook ID)=AA36-240
#COLLECTION
CO:COLLECTION_SUMMARY            	Subjects and design: This study is part of a larger study on the influence of
CO:COLLECTION_SUMMARY            	storage time of platelet concentrates in a two-hit healthy volunteer model on
CO:COLLECTION_SUMMARY            	transfusion-related acute lung injury; the results of this study must therefore
CO:COLLECTION_SUMMARY            	be considered exploratory [Transfusion. 2022;62(12):2490-2501.]. The sample size
CO:COLLECTION_SUMMARY            	was determined based on the primary outcome of the overall study,
CO:COLLECTION_SUMMARY            	bronchoalveolar lavage fluid protein content, as previously described
CO:COLLECTION_SUMMARY            	[Transfusion. 2022;62(12):2490-2501]. Male subjects, aged 18-35 years, were
CO:COLLECTION_SUMMARY            	allocated to participate in this part of the open-label randomized controlled
CO:COLLECTION_SUMMARY            	study. Subjects underwent a pre-participation screening process, which included
CO:COLLECTION_SUMMARY            	a review of their medical history, assessment of vital signs, physical
CO:COLLECTION_SUMMARY            	examinations, and laboratory tests encompassing blood and urine analysis.
CO:COLLECTION_SUMMARY            	Subjects were prohibited from engaging in any other intervention trials both
CO:COLLECTION_SUMMARY            	three months before and after the study. Prior to enrollment, all volunteers
CO:COLLECTION_SUMMARY            	provided written informed consent. In our current analysis, solely subjects
CO:COLLECTION_SUMMARY            	(n=24) who received a platelet transfusion were included. The study procedures
CO:COLLECTION_SUMMARY            	have been reviewed and approved by the Amsterdam UMC Medical Ethical Committee
CO:COLLECTION_SUMMARY            	(2014_294#B2014961) and are according to the principles of the Declaration of
CO:COLLECTION_SUMMARY            	Helsinki and Good Clinical Practice (GCP). The study is registered at the
CO:COLLECTION_SUMMARY            	International Clinical Trials Registry Platform (ICTRP): NL-OMON26852.
CO:COLLECTION_SUMMARY            	Randomization and blood donation The first 12 subjects (part I) were allocated
CO:COLLECTION_SUMMARY            	to receive Escherichia coli (O113) lipopolysaccharide (LPS; dose 2 ng/kg; lot
CO:COLLECTION_SUMMARY            	number 94332B1) to incite an inflammatory condition through toll-like receptor 4
CO:COLLECTION_SUMMARY            	stimulation, whereas the last 12 subjects (part II) received an equal volume of
CO:COLLECTION_SUMMARY            	physiological saline (0.9% [w/v] sodium chloride) as control [Blood.
CO:COLLECTION_SUMMARY            	2006;107(2):637-641 and Platelets 2016;27(5):479-483.]. Subjects were scheduled
CO:COLLECTION_SUMMARY            	to participate twice, once with and once without LPS, with a minimum interval of
CO:COLLECTION_SUMMARY            	one year between sessions. Subjects were randomly assigned to receive one of the
CO:COLLECTION_SUMMARY            	following: short-term stored autologous PCs (2 days stored) or long-term stored
CO:COLLECTION_SUMMARY            	autologous PCs (7 days stored). Treatment allocation concealment was achieved by
CO:COLLECTION_SUMMARY            	generating a randomization sequence using R (version 4.3.2, Boston, MA, USA).
CO:COLLECTION_SUMMARY            	The sequence was placed in consecutively numbered opaque envelopes, which were
CO:COLLECTION_SUMMARY            	opened only after each subject's inclusion. Depending on group allocation, the
CO:COLLECTION_SUMMARY            	subjects donated 1 unit (± 300 mL) of apheresis platelets 2 or 7 days before
CO:COLLECTION_SUMMARY            	the study day at Sanquin Blood Bank. Apheresis PCs were obtained and stored in
CO:COLLECTION_SUMMARY            	compliance with Dutch Blood Bank standards, and preserved in 100% platelet
CO:COLLECTION_SUMMARY            	additive solution E (PAS-E). The trial was conducted as an open-label randomized
CO:COLLECTION_SUMMARY            	study, as subjects were required to donate either 2 or 7 days before the
CO:COLLECTION_SUMMARY            	experiment.
CO:SAMPLE_TYPE                   	Platelets
#TREATMENT
TR:TREATMENT_SUMMARY             	Biotinylation of platelets: On the day of the transfusion, platelets were
TR:TREATMENT_SUMMARY             	biotinylated according to GCP as previously described [Transfusion.
TR:TREATMENT_SUMMARY             	2019;59(9):2964-2973.]. In total, 50 mL of the platelet concentrate was
TR:TREATMENT_SUMMARY             	biotinylated with 5 µg/mL of NHS-biotin (EZ-Link™, Thermo Fisher Scientific,
TR:TREATMENT_SUMMARY             	Waltham, MA) and returned to the storage bag. Experiment: Subjects were admitted
TR:TREATMENT_SUMMARY             	for one day to the research unit of the department of intensive care of the
TR:TREATMENT_SUMMARY             	Amsterdam University Medical Center, the Netherlands. Before the study
TR:TREATMENT_SUMMARY             	procedures, a research physician assessed the subjects, and blood was cross
TR:TREATMENT_SUMMARY             	matched as an additional safety procedure. A peripheral venous catheter (18 G;
TR:TREATMENT_SUMMARY             	BD, Plymouth, United Kingdom) was inserted to administer 1L of normal saline for
TR:TREATMENT_SUMMARY             	prehydration one hour before the experiment began. Maintenance fluids were then
TR:TREATMENT_SUMMARY             	set at 1.5L of physiological saline per 24 hours until the conclusion of the
TR:TREATMENT_SUMMARY             	experiment. An arterial catheter (20 G; BD, Plymouth, United Kingdom) was
TR:TREATMENT_SUMMARY             	inserted using ultrasound into the radial artery. During admission, subjects
TR:TREATMENT_SUMMARY             	underwent continuous monitoring, including blood pressure, temperature, heart
TR:TREATMENT_SUMMARY             	rate, and respiratory rate. Blood samples were collected from the platelet
TR:TREATMENT_SUMMARY             	concentrate (PC) storage bag for further analyses as described below. Following
TR:TREATMENT_SUMMARY             	the completion of safety checks and sample collection, subjects were
TR:TREATMENT_SUMMARY             	administered either LPS or control. Two hours afterwards, a 300mL autologous PC
TR:TREATMENT_SUMMARY             	(including 50 mL biotinylated platelets) was infused over exactly 50 minutes
TR:TREATMENT_SUMMARY             	before the infusion set was locked and the post-transfusion period commenced.
TR:TREATMENT_SUMMARY             	Ten minutes, 30 minutes, 1, 2, 3, 4, and 6 hours post-transfusion, blood samples
TR:TREATMENT_SUMMARY             	were drawn from an arterial line and further processed and analyzed.
TR:TREATMENT_SUMMARY             	Additionally, platelet counts were measured before and after transfusion using a
TR:TREATMENT_SUMMARY             	hematology analyzer (XN-9000, Sysmex, Norderstedt, Germany). The platelet
TR:TREATMENT_SUMMARY             	increment was determined by the difference in platelet count before and 1 hour
TR:TREATMENT_SUMMARY             	after the transfusion, and the corrected count increment (CCI) was calculated by
TR:TREATMENT_SUMMARY             	platelet count increment per µL × body surface area (m²) / unit content. On a
TR:TREATMENT_SUMMARY             	return visit, 48 hours post-transfusion, the last blood samples were collected
TR:TREATMENT_SUMMARY             	using venipuncture. Whole blood samples were drawn using citrate tubes (BD,
TR:TREATMENT_SUMMARY             	Plymouth, United Kingdom).
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Platelet concentrate aliquots were thawed on ice then metabolites extracted from
SP:SAMPLEPREP_SUMMARY            	a 20 uL aliquot using 180 uL of cold 5:3:2 MeOH:acetonitrile:water. Samples were
SP:SAMPLEPREP_SUMMARY            	vortexed 30 min at 4 degrees C then supernatants clarified by centrifugation (10
SP:SAMPLEPREP_SUMMARY            	min, 10,000 g, 4 degrees C) and transferred to autosampler vials.
SP:PROCESSING_STORAGE_CONDITIONS 	4℃
SP:EXTRACT_STORAGE               	-80℃
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Positive C18
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Vanquish
CH:COLUMN_NAME                   	Phenomenex Kinetex C18 (30 x 2.1mm, 1.7 um)
CH:SOLVENT_A                     	100% water; 0.1% formic acid
CH:SOLVENT_B                     	100% acetonitrile; 0.1% formic acid
CH:FLOW_GRADIENT                 	0-0.3 min 5-95% B at 0.45 mL/min, 0.3 to 0.8 min hold at 95%B at 0.45 mL/min,
CH:FLOW_GRADIENT                 	0.80-0.81 min 95-5%B and increase to 1 mL/min, 0.81-1.0 min hold at 5%B at 1
CH:FLOW_GRADIENT                 	mL/min, at 1 min decrease flow to 0.45 mL/min
CH:FLOW_RATE                     	0.45mL/min - 1mL/min
CH:COLUMN_TEMPERATURE            	45
CH:SAMPLE_INJECTION              	10 uL
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	Resolution 70,000, scan range 65-900 m/z, maximum injection time 200 ms,
MS:MS_COMMENTS                   	microscans 2, automatic gain control (AGC) 3 x 10^6 ions, source voltage 4.0 kV,
MS:MS_COMMENTS                   	capillary temperature 320 C, and sheath gas 45, auxiliary gas 15, and sweep gas
MS:MS_COMMENTS                   	0 (all nitrogen).
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	peak area
MS_METABOLITE_DATA_START
Samples	AA36-1	AA36-2	AA36-3	AA36-4	AA36-5	AA36-6	AA36-7	AA36-8	AA36-9	AA36-10	AA36-11	AA36-12	AA36-13	AA36-14	AA36-15	AA36-16	AA36-17	AA36-18	AA36-19	AA36-20	AA36-21	AA36-22	AA36-23	AA36-24	AA36-25	AA36-26	AA36-27	AA36-28	AA36-29	AA36-30	AA36-31	AA36-32	AA36-33	AA36-34	AA36-35	AA36-36	AA36-37	AA36-38	AA36-39	AA36-40	AA36-41	AA36-42	AA36-43	AA36-44	AA36-45	AA36-46	AA36-47	AA36-48	AA36-49	AA36-50	AA36-51	AA36-52	AA36-53	AA36-54	AA36-55	AA36-56	AA36-57	AA36-58	AA36-59	AA36-60	AA36-61	AA36-62	AA36-63	AA36-64	AA36-65	AA36-66	AA36-67	AA36-68	AA36-69	AA36-70	AA36-71	AA36-72	AA36-73	AA36-74	AA36-75	AA36-76	AA36-77	AA36-78	AA36-79	AA36-80	AA36-81	AA36-82	AA36-83	AA36-84	AA36-85	AA36-86	AA36-87	AA36-88	AA36-89	AA36-90	AA36-91	AA36-92	AA36-93	AA36-94	AA36-95	AA36-96	AA36-97	AA36-98	AA36-99	AA36-100	AA36-101	AA36-102	AA36-103	AA36-104	AA36-105	AA36-106	AA36-107	AA36-108	AA36-109	AA36-110	AA36-111	AA36-112	AA36-113	AA36-114	AA36-115	AA36-116	AA36-117	AA36-118	AA36-119	AA36-120	AA36-121	AA36-122	AA36-123	AA36-124	AA36-125	AA36-126	AA36-127	AA36-128	AA36-129	AA36-130	AA36-131	AA36-132	AA36-133	AA36-134	AA36-135	AA36-136	AA36-137	AA36-138	AA36-139	AA36-140	AA36-141	AA36-142	AA36-143	AA36-144	AA36-145	AA36-146	AA36-147	AA36-148	AA36-149	AA36-150	AA36-151	AA36-152	AA36-153	AA36-154	AA36-155	AA36-156	AA36-157	AA36-158	AA36-159	AA36-160	AA36-161	AA36-162	AA36-163	AA36-164	AA36-165	AA36-166	AA36-167	AA36-168	AA36-169	AA36-170	AA36-171	AA36-172	AA36-173	AA36-174	AA36-175	AA36-176	AA36-177	AA36-178	AA36-179	AA36-180	AA36-181	AA36-182	AA36-183	AA36-184	AA36-185	AA36-186	AA36-187	AA36-188	AA36-189	AA36-190	AA36-191	AA36-192	AA36-193	AA36-194	AA36-195	AA36-196	AA36-197	AA36-198	AA36-199	AA36-200	AA36-201	AA36-202	AA36-203	AA36-204	AA36-205	AA36-206	AA36-207	AA36-208	AA36-209	AA36-210	AA36-211	AA36-212	AA36-213	AA36-214	AA36-215	AA36-216	AA36-217	AA36-218	AA36-219	AA36-220	AA36-221	AA36-222	AA36-223	AA36-224	AA36-225	AA36-226	AA36-227	AA36-228	AA36-229	AA36-230	AA36-231	AA36-232	AA36-233	AA36-234	AA36-235	AA36-236	AA36-237	AA36-238	AA36-239	AA36-240
Factors	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Fresh | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:Bag | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:0 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:2 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:3 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:6 | Sample source:Platelets	Sample type:Platelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets	Sample type:BioPlatelets | Fresh v stored:Stored | Treatment:no LPS | Timepoint:48 | Sample source:Platelets
L-arginine	8044070	7372745	19589550	3978	2923714	4199403	677651	3074233	932	1822293	12260193	2973	955	35302	2138654	134290	2179590	2071015	17767	170378	3604	16036515	13221	20716944	61548	24584	41012	28157	9218	2052190	861	13858656	22875	11615129	149973	1594980	27964	7277	2075624	67590	29959608	34666508	32848	2158248	3018372	20997	2755319	10886	19011	168119	9501	14603	87220	20273	697	107808	4469205	81623	1834	41377	81819	25291	8173	40932	24225	10681	70450	23259	117617	292033	27486866	15324639	3867	14039	31470	10280	54669	17867	26249	16004	18875	4532	1892	27124	17654	56992	153053	28039	8607	64216	2390	27435	65452	12984	10394	845	8533	103419	57317	10791	23477102	14139	8648838	55735	2728076	493087	4264156	133012	3522579	129312	16082692	2914	8249769	4747103	12159	102720	1505614	912287	4595536	15894	16554	30973	67503	60092	9162	4794	15972213	35479	23210954	65760	21854334	228964	142307	9149	28147	33475	24677	5788	4523	6767	17831778	11784635	55067	10885671	3862	17825	4186	29332	228959	3534	14742889	198097	25508	44499	28388	3083	17813	57042	36313	12551959	83600	43037	7585	3328	463622	5189191	237759	6855056	43360	4511	1935	54142	14053	22639	3398	1374	12155	90609	9954	8251	90937	64838	3077	3650	14423	33338	14782	76754	15866	210626	16401448	218064	113449	5727823	7595982	628527	12875501	49649	13089504	108587	15659791	8006489	4441151	4924229	4957956	486509	123221	6685	15186692	74272	11635617	129641	6831226	6801442	12702056	653458	11219136	585707	7577816	2428639	10064757	7931271	4366009	6320340	11217204	174969	9487103	1347608	13002597	312851	23034	22167538	6261784	12874232	27897456	1935464	11868955	115162	15655251	457334
L-lysine	2020674	389197	1870400	6329	322656	197856	129871	145113	3688	277870	1575214	6781	3922	15723	223094	56178	247761	126714	8070	70433	6360	1362020	9975	1640386	18321	13649	22055	14456	8541	96291	4580	2379250	12888	632813	13552	61999	15000	5079	1380085	26844	2677557	3684303	23379	1260281	1440713	11569	1764095	6601	14363	75348	6036	16677	37365	12916	3977	34809	1643980	21780	4298	18118	22176	15006	11352	11599	16123	10779	30534	8819	62036	116787	2352456	1255396	4585	8585	17925	7815	16008	8681	15760	9195	15915	6205	5309	13032	9502	19545	34752	28308	10885	27962	4854	16610	25982	9909	7715	4126	8448	28497	33797	7094	1866023	9318	2498174	21660	1110775	114735	1647504	61585	1917557	37303	1717125	5677	1836553	782955	8308	29389	296569	111632	2330881	9022	7708	11196	23961	31317	13844	5861	1224605	24456	1680766	53389	2338945	59737	30108	7345	36751	26372	13315	6049	7143	4828	1981269	1141030	15460	2680896	4569	12850	6018	20436	79204	4449	1789024	59902	14566	17210	13189	5506	10704	26328	22754	1390632	33055	24769	6634	4015	34459	692810	21999	684579	30783	6358	7228	13477	13008	12986	3809	6067	7106	36735	8375	7759	47507	39878	5944	5651	9961	17587	10066	54043	19182	34071	1556743	71318	30251	1554389	943147	67548	1114556	23913	1018213	37425	1768677	943333	1414196	1380719	550940	64630	51728	7675	1447765	27728	1440016	64627	1571166	1686420	921868	60919	1211951	29636	605253	202877	1392861	832766	1854778	2141326	1442682	76550	886524	114117	1236218	40523	13823	1925785	1720519	2823157	2707919	205671	1181589	42412	1437550	46223
L-valine	33854964	7064235	34373924	1349290	9234247	2703033	3116562	3098292	1292471	5749076	26130002	1443872	1242121	1068931	4579184	1341264	5912321	1730245	1325196	1489574	1238335	15499073	1313721	20245936	891170	1102940	1259702	1175695	1473981	3205687	1397784	34034128	1296980	19318490	1693103	1856199	1305348	1595722	31934606	1069882	32888894	39230664	940444	33461776	52497824	1175881	62734708	1267370	1164697	1604259	1261195	1115244	1158643	1288533	1416210	1378777	36097788	1334990	1428450	704982	1132760	1300211	1161838	924661	1045194	1029372	1164818	1275290	9486493	3552487	32120010	17059674	1337086	996617	1030759	957797	920892	1391059	1217937	1300583	1395011	1418331	0	856377	1224500	1107730	1223646	1155826	1120265	1669876	1358452	1408370	1160205	1451538	1424323	1379004	1323958	1274490	1329618	1261850	27180674	1209786	43031236	970357	42057952	3742302	41683328	1644057	60944292	1475578	29865752	1376786	36304820	18566894	1496092	1968277	33343926	5243868	53377584	1482077	1376042	1344496	1371830	1457595	1130486	1193382	27913546	1510173	34566248	1729285	37551776	1455270	1506988	1360417	1440749	1185900	1361972	1474222	1114161	1411493	28983750	16160909	1202663	42225044	1405196	1195811	1127485	1297911	1619648	1309482	21742078	1580913	1472516	1389046	1376294	0	1690228	1323442	1631026	19109650	1480847	1144014	1490414	1462002	1615244	19643522	1514871	24496570	1212099	1352147	1440761	1370918	1327479	1447220	1488775	0	1457283	1246028	1293168	1318495	1443290	1461465	1425165	1251726	1226852	1003878	1392776	1645502	1309332	1533354	35796320	1525012	1561324	26850738	27467984	3177631	30573840	1412609	26195754	1547258	28095462	14146843	29586136	26964602	17673854	1622898	1445245	1418945	37075884	1593953	27008448	1767413	38514136	43795684	36912712	2429943	29456384	1948409	31831520	4291749	19394656	11256245	22255654	24847570	28147990	1742679	20565090	3933377	28323040	2154578	1247683	25436378	33099856	38494828	39353944	3821247	26238160	1602178	34945332	2155961
Adenosine	1138791	1995030	3145412	308303	579040	711941	381596	696951	318049	1405085	3331775	373658	317140	390930	482755	301664	559328	506790	492333	410587	328225	1837391	375650	4872079	286880	354700	441928	378560	334964	394851	298782	580637	346634	6187315	388099	874321	317466	451102	1212825	303511	720075	1073518	333886	386657	7890172	295661	3444881	415561	370755	339460	394452	392629	278430	370156	326002	310535	3096289	356197	334322	342930	350823	339027	397828	332698	391586	368056	348555	411868	959968	376985	2854263	2398753	395283	381675	405970	331735	338654	418199	357055	258043	327668	298360	315642	325738	407498	401328	253892	384841	366042	379721	321188	372468	240684	368199	370526	327180	281387	236394	206969	220772	1355842	246972	958428	164862	3713133	3657907	10259031	210688	6322151	272144	3574933	248137	709508	1624485	273840	708117	1505881	2378298	10940589	286085	259971	268211	265160	254631	218758	246159	4922248	257698	4635920	225244	10180870	237494	277450	261135	216229	262268	255386	273553	207684	239427	4070874	1695217	214986	1882565	249248	264755	244932	230748	245254	237806	6769066	234351	262378	262821	271950	249666	241837	268004	243554	1507656	246378	241434	258108	259745	359892	6581326	376263	23529778	228539	216244	288491	259598	238624	281507	265713	246824	267306	208808	294919	286410	227633	158432	266932	250469	249158	212118	278329	232718	243003	532249	5569941	266378	230213	547235	2995809	690400	3881268	211250	6182434	222539	7472993	2728254	1089307	1219759	9848849	409441	198965	221730	6169504	216333	3323211	242086	1497935	1174329	5794095	345227	2207338	298725	6407920	384394	4800932	1702850	749380	899515	18187150	254598	4535445	324834	3757968	256447	237732	1005578	1067792	496965	2056783	375019	8233711	276775	7360922	398691
Adenine	256664	1121515	1817922	126766	153581	178782	131675	181096	123353	287225	1357318	149614	118421	159083	167886	151852	151700	165409	155837	148359	130223	1706063	172463	2169130	133796	139716	129249	136978	137409	135355	123427	162065	142825	1676161	103242	395987	141795	152705	451421	156278	463187	475572	114160	117959	888493	131728	432779	139344	154328	155387	155563	131675	156570	167543	120517	140213	913236	159143	124059	105071	153398	151780	120106	139248	125676	119533	154409	152804	183515	175724	905487	878470	151332	127710	142309	121796	138129	165951	147881	131001	167074	128852	119993	106624	145795	126421	116954	133980	129225	162793	134203	155307	107162	172804	131223	124696	113816	104453	146055	123054	1440272	112976	273997	101783	1592101	370232	7116723	163229	1858379	136844	2037432	114415	148428	197460	147138	133309	287972	244992	2462034	180131	124012	124278	126037	137751	93613	102215	1664065	154093	463355	148430	7950006	149372	144233	124559	135651	136615	136644	133906	93061	103824	2855844	1521675	0	215024	105687	130066	112867	132950	142442	119717	4912970	193924	141722	111639	115118	103085	152279	127750	152377	885695	145629	131420	117412	111707	157894	1218486	140992	4436617	127277	125614	125596	105420	123182	127479	121182	102576	156695	124372	112653	117233	127920	104704	111899	102720	103765	100817	124115	162889	105314	112785	1866190	169380	170796	210815	418060	154082	503851	144492	1120030	209415	6174603	2610315	184349	246048	1725104	182905	175461	120123	877710	151600	2493651	177921	246760	279383	741889	154560	332394	133743	1526671	180501	3189842	1585128	166191	184800	4302934	170586	1381291	144148	1057398	116443	109948	676094	191583	186363	462424	108286	1100864	208512	1069359	155152
Uracil	237754	205110	393372	16552	37023	33871	23113	23309	14710	61617	212143	17082	13980	14308	22799	22212	23055	25367	14580	19053	16829	181867	14401	386089	16340	14057	14123	13026	17250	18939	16603	231177	16565	194121	18509	27842	13475	15844	278828	12874	207431	271451	10114	81273	310453	16238	286968	17561	15706	14488	15105	13395	14227	17249	15064	16184	446800	15230	15543	12626	15181	15339	11399	14081	13304	14024	13833	15216	23902	20684	434928	180365	15141	11561	13353	12716	15374	17133	17293	15535	16394	15088	14054	12015	15088	9693	18716	13717	12284	16131	16325	15474	14843	14044	15876	14053	13336	17852	15503	16266	562135	14853	307814	16136	510457	36168	629183	23834	610847	16826	418188	13665	245203	64652	14666	24513	77941	33394	712853	14302	16009	16989	18010	18012	12628	17580	409076	16166	411786	15415	552030	18809	17968	17368	17295	15154	16545	17733	14824	13922	320295	171608	13514	445379	17388	16477	16823	16592	23754	14394	383066	21366	14879	17004	15609	14719	16460	15726	17299	190118	19650	13993	18237	16694	21675	63743	11991	633881	15941	13201	17843	17329	14291	16195	16400	13604	17689	16751	15299	16481	17574	16008	17155	12713	14501	15525	16114	16338	16228	19096	844514	19376	17049	151263	371638	49012	481978	17741	436730	20805	601867	324455	384760	755911	317139	44052	22209	15535	373158	21918	409941	24992	215037	323148	208346	23132	223624	17413	222144	41167	413058	130433	362226	469159	880162	25485	161337	34718	281037	19074	16388	292060	308266	507169	505455	48729	368198	22612	289093	30977
IDP	54961	11364496	2369723	0	15993771	17338886	2228604	16368117	0	65836	8816132	345	0	0	10735561	1925	16387616	20830152	0	960	0	4391628	1967	1877534	0	0	666	0	577	13236619	0	60403	3434	4243235	2947205	20277216	488	19168490	479329	1012	2846773	3782257	0	46816	3270730	0	3121670	0	1671	3964	0	385	7891	1570	0	488	2879728	0	0	0	584	0	0	0	0	520	1414	0	4274636	19708	3227370	4913733	0	0	0	0	0	0	0	539	0	0	0	547	0	0	577	0	0	1327	0	0	462	6610	0	0	0	4216	1012	364	3159113	1144	54394	890	2594817	17223094	3376118	828	1913357	4309	5496424	0	75822	9569339	4665	2981519	15889289	16160973	911697	6239	0	396	3015	0	0	0	2354980	6360	1291160	0	2247999	7985	0	2068	0	1494	0	894	0	0	4379988	4669393	0	49137	0	0	0	0	9933	507	2005466	3335	2802	2134	0	0	0	1802	8744	6070059	0	3829	0	0	20561814	7214507	19744064	2704779	831	541	385	0	0	1519	0	0	6972	2775	0	0	2996	643	0	0	0	519	0	825	0	6966849	319941	1362	0	36541	183896	6357590	1232794	1624	1547924	0	2439994	3322226	32991	79167	3074524	11154221	3027	473	581501	1167	3290553	2894	65768	39303	1638826	9132733	1276203	13662417	4254325	8440459	3450895	4364614	59800	90977	711214	2426	2533651	7879622	954211	6689394	0	3565624	55561	64858	1726841	13041301	2920027	937	2168279	14577612
5-Hydroxyisourate	974900	44899	1012889	0	43695	0	15212	4852	0	33338	264058	0	0	0	8578	6530	33318	7361	0	10523	0	365878	0	1019691	0	0	0	0	0	0	0	1305883	0	1520010	0	0	440	0	1678649	824	799015	809119	2006	471583	959980	0	1247391	0	0	6094	0	526	761	0	0	0	1294868	0	0	0	0	0	0	0	0	0	1497	0	0	16555	771540	280352	0	0	0	0	0	0	0	0	0	0	0	0	0	839	649	2844	0	677	0	0	0	0	0	0	0	0	2243	0	1184890	0	1058625	0	1004539	0	1272528	15803	2385789	2073	265680	0	900466	230227	0	0	17379	0	3544775	0	0	0	0	0	0	0	1679905	0	2408552	11824	1085339	5031	5903	0	2517	0	0	0	0	0	424227	194241	523	1122671	0	0	0	0	4223	0	1022485	8852	0	0	0	0	0	564	1148	196891	2374	1218	0	0	0	970820	0	1256514	770	0	0	0	0	0	0	0	0	594	0	0	7923	1168	0	0	0	0	0	4608	0	0	1848591	9262	4505	959596	2388381	7211	1511517	0	1733500	8471	485854	256144	778413	1161780	486192	0	4005	0	2155581	0	325408	15547	967495	1191232	1802842	0	1175614	0	706103	3710	586663	376114	935787	1428368	3417199	15366	1446323	18673	3355883	0	0	345293	1274914	1286713	1807322	7973	1419245	3048	1845155	0
5-6-Dihydrothymine	3114603	216296	1884762	21981	1142160	67959	331158	244173	20081	269515	571211	20634	21860	22099	388322	35550	613146	53132	15918	34933	19246	500212	20723	787696	17785	16999	21922	19463	19630	123097	20880	1892693	22207	1149086	28552	100675	20892	26625	937586	19836	1139784	1033000	18946	2755811	1434790	17979	1352462	22090	22717	52151	19137	18175	26439	21340	19994	17300	952674	16219	18995	21180	24989	21674	19785	20653	19329	16480	29410	21348	128021	141538	1588834	665281	20075	17274	20863	19262	17830	18266	20913	18007	19787	18014	18516	18931	21171	25639	20223	24492	19437	28806	15604	23489	20186	19177	20117	22856	19496	24861	27236	19411	783051	20590	1655127	25220	830021	39021	822581	38881	1380149	21535	896406	19705	1486114	969034	19954	27233	224489	26381	1158242	23843	19867	20823	22616	23785	20133	18439	2287536	22132	2383032	33164	1441028	27774	32367	21065	18174	21183	19851	19349	22569	19987	1685668	844886	21571	2480076	19239	16402	18084	18777	37444	21108	857666	44810	24077	19988	18601	19747	20669	20440	25712	2100895	23328	24470	17800	19756	147902	2658366	92441	3631057	18922	21526	23245	20352	22105	21789	21691	21401	20723	25430	20164	21129	33859	28946	20196	17725	23046	18827	21785	25800	18640	63536	2582682	50248	36252	3358941	2485407	207238	2364498	23370	2663567	33150	1028938	498082	1734903	1730582	934328	62425	32672	19745	1364631	24156	1796378	56487	1916867	2155523	1571135	172517	1255104	88741	1047691	221926	1126556	472042	1814319	1891333	1652370	53357	1059748	227681	1621949	114786	18130	359782	1887431	1764761	1187433	240116	1225350	43377	1253469	140652
4-Pyridoxate	129965	21198	13564	1503	14018	0	2425	10712	1343	13826	22323	880	2297	776	754	854	22787	9158	2208	860	908	7200	1141	37338	0	2709	620	0	1092	5568	1942	18598	1774	114123	23245	1538	1366	1703	64882	1524	12810	16365	548	12311	161782	732	103963	1445	1937	663	967	1165	1101	1257	1354	1878	127662	798	417	623	929	935	790	750	2001	1362	991	1292	7176	16497	49842	12844	847	1984	556	1352	607	803	642	1549	993	908	1759	1172	487	770	589	572	0	1568	2021	1270	1884	1824	580	1069	1913	1032	796	1328	65208	872	91094	2361	11494	12236	112257	617	59227	2081	47372	1309	53049	21177	1252	2170	6528	3837	233892	2068	568	1684	2791	1325	1503	2007	84583	1498	146587	942	304981	1113	949	1603	734	1081	1385	1530	1548	591	11673	9661	1454	47884	1735	811	346	1005	1434	751	150861	969	1236	2255	1310	1206	988	1549	618	9804	878	1333	2140	717	8039	300768	2170	478202	843	849	1464	1073	1622	1675	625	1442	2292	1651	894	795	1051	797	941	863	1341	1666	1084	1520	890	4615	51257	1254	1109	11613	1611	5691	37385	926	157086	830	70909	15370	51947	32091	126760	4949	1233	2114	96530	952	60130	1079	65518	94593	32206	3286	34931	1120	179357	8602	194728	182093	23876	15560	112245	1381	13890	6855	49719	1287	1883	10112	18235	23386	95279	7598	160529	838	254771	7168
Nicotinamide	77219576	55499772	121613064	131692	9348517	9166353	3521944	13218144	116732	3502907	70021344	178289	124927	233259	3671449	439535	4324452	2206457	145049	485138	145037	64376532	167869	90080352	202310	162383	192317	189209	148123	4271562	130279	18540062	189208	83300728	397113	6220854	158486	244654	31041376	310664	61395120	84743184	233590	4612772	123239016	162230	93495608	159498	182483	247990	156626	213537	271385	188686	130543	160041	75130312	235069	126960	193252	218337	168987	163199	160242	175269	157141	248781	147171	3414313	345507	96501928	74017832	143173	150872	186509	136700	191137	150226	177778	129252	190270	148916	120756	148417	158603	240172	199795	286596	186670	188691	132563	151677	127206	199354	136719	123615	136611	234177	224027	138301	79043160	131201	64838068	163895	42993380	3871304	131555160	451638	99700536	312119	95811272	128279	31558960	13102179	157137	546566	19378734	1187168	121054184	209865	135025	198598	208775	235261	144354	125493	109533384	235170	117674072	410901	137062256	378949	372620	144033	253768	173646	179336	155198	127622	119905	86101368	67840856	212168	59768156	134922	148437	138355	156593	399310	118485	84289952	459973	196581	187354	160745	119153	181166	178953	285188	50226028	275687	176359	140694	121632	2446555	106544392	1657502	163594240	183532	130631	159055	179849	146144	186083	125522	135264	202583	206419	134597	145680	233742	163524	140320	125985	156416	134044	141334	339791	204137	681532	90574560	409686	407876	19308518	35513268	4680024	71955448	262867	114620936	457757	150416016	96761128	27793866	34894700	64378956	2095464	419461	141371	112046232	313427	91608600	465202	46166780	75848224	84861448	2995832	35867512	2106747	108150784	6034286	90218776	80992040	16600495	31070854	139897312	431497	53069076	4330735	61881184	1794444	177258	66463808	24829432	24270810	66179396	3589913	98656640	444411	118847160	3302038
D-Ribose	718749	604097	1728474	5103	105373	149663	42886	83797	4352	72793	1356800	8657	5060	8312	28446	11484	12352	10173	8441	13227	6019	1433955	6835	2263951	7902	8377	9366	8759	6461	22448	6657	441943	5644	808207	8612	126647	5639	12554	983257	6114	1693696	2203985	10750	116843	2017832	6365	1945053	7216	6548	6224	7405	10657	7900	8027	6008	6219	1669786	10010	4539	9313	9680	6302	11819	6534	8535	9985	7463	6542	46165	11735	2819025	1688240	8317	6559	8985	6499	7983	8424	8200	5154	6942	5171	5143	8318	8881	15214	8918	13617	9371	6726	5403	7024	6718	6586	5302	5935	6293	8113	8765	4873	2489645	5203	1144501	6430	1853365	20807	3459904	12957	3209373	5416	2539974	5734	424333	264973	5666	19934	268013	27967	2840998	5590	5469	6054	6538	7575	6072	6935	1369084	6084	1991148	11136	2156709	9884	12778	5072	7343	6309	5338	5721	5263	5782	1506911	1157708	6593	881530	6848	6306	6125	6525	11115	5310	882682	10854	6107	3685	6150	5839	5481	5626	5726	747989	6375	6543	4489	4415	13084	424590	11257	901766	5935	4675	5861	6270	6052	5996	6591	5279	6036	7874	6999	7060	8422	6872	5702	6014	5458	5672	6728	10605	7659	5263	2167080	12362	9221	243119	760814	26698	1624240	5735	1971617	9770	2342643	1513878	346019	328572	350761	12637	9415	5782	1552185	6946	1147385	9516	415899	964576	1154842	18967	626124	14989	1108116	112763	729527	737188	184732	317493	1151371	8996	666558	47316	745984	4630	5752	1863369	291184	623675	1966485	54188	1459196	11948	1665429	32884
S-Glutathionyl-L-cysteine	99470	130948	327773	0	13673	0	8369	4580	0	18019	325872	0	0	0	0	2468	7575	0	0	3528	0	512028	0	304547	0	0	0	0	0	0	0	48107	0	313416	0	0	0	0	165403	0	463685	446338	1681	6564	233229	0	132067	0	0	703	0	544	685	0	0	0	229404	642	360	0	0	0	425	0	585	0	0	0	7553	10795	284746	213008	0	0	826	0	0	0	0	0	0	0	0	0	0	1735	0	3813	1232	0	0	0	0	454	0	0	0	0	1711	0	286692	0	113906	0	183354	0	111030	4077	242981	0	424383	0	86179	19113	0	0	9350	0	218121	0	0	0	0	0	0	0	493226	1572	481014	2084	664327	0	0	0	1484	0	0	0	0	0	799018	469242	0	146296	0	0	0	544	864	0	635473	1460	0	0	0	0	0	0	619	704707	1348	0	0	0	0	334817	0	332423	0	0	0	0	0	0	0	0	0	0	0	0	3546	1109	0	0	0	0	0	3170	0	0	459638	1472	0	113345	150052	23484	299209	0	367705	0	952720	661439	92021	189917	304334	0	0	0	471753	0	693530	2630	79959	99423	469585	10963	274994	0	177204	18593	530196	408350	120960	98417	471180	1271	255715	20692	375902	6524	0	383594	84604	51059	172461	8682	174572	0	166520	0
(5-L-Glutamyl)-L-glutamine	146048	12275	92394	0	33629	6969	34912	12967	0	76194	174960	0	0	2120	41444	6574	12356	0	0	13153	0	46967	477	254775	618	656	2710	640	0	10206	0	231614	646	218513	0	0	644	0	245123	2895	69127	108943	3319	71166	294519	0	254054	0	681	5547	0	2790	2910	0	0	685	295458	0	0	0	961	529	0	0	0	0	1915	925	4780	7910	140366	69444	0	0	651	0	0	0	0	0	0	0	0	0	1304	2863	0	2403	0	1598	0	0	0	0	0	0	0	4056	3305	0	301646	0	279534	1212	132545	7001	301152	10865	388213	4100	78362	0	302408	103355	0	0	46877	0	389240	905	548	0	3233	589	1396	0	198166	1808	251741	9008	152733	7244	5671	0	4936	864	780	0	0	0	65911	67435	1589	349932	0	511	0	3563	5787	0	150782	2899	1397	1123	0	0	0	982	2885	45977	3112	2261	455	438	1408	195542	0	173586	3605	0	0	1715	682	533	0	0	387	3674	0	0	7947	7208	0	0	0	609	0	5305	2096	711	325680	8034	7116	297216	263633	5735	234866	738	219036	3692	97758	67707	111740	138184	69105	0	3508	0	201874	2145	74658	7372	201153	317757	158565	0	133574	0	135774	0	64412	125199	125671	170414	125046	7747	125880	7023	234965	0	1431	78934	155702	168025	265050	930	239476	4101	347729	0
Dimethylglycine	723274	65845	494911	37006	205064	57423	76646	79864	36143	604704	398659	40797	36920	43073	128402	44135	155047	64631	42440	48473	31284	147061	41136	280948	41831	46663	50645	41286	37748	77410	33483	888575	36772	435702	74976	46101	39734	53226	503461	46648	340053	388191	46301	867707	1105895	36914	960032	42564	42985	50248	45336	56186	41667	43870	39486	32144	624011	43824	32243	42433	39857	36215	50164	47574	45016	45894	39239	46729	143420	93718	392828	140763	43410	46176	47877	51768	41412	48692	40913	36443	41259	37096	36313	48464	43912	58583	32245	51279	54607	42645	33835	39174	33176	42760	36929	33781	36424	31972	36265	34338	564327	30174	1254006	30482	757934	79591	989078	35741	1438853	30864	472896	32356	960098	470052	29792	52119	207447	63093	1120366	35568	29645	31574	33156	33220	28643	28656	567388	34433	510895	43636	534659	35362	36722	34957	35323	35204	32884	35558	25497	29622	603131	277160	32132	804900	28555	32124	29271	28543	38327	32756	445486	34548	37447	31073	28874	33807	35638	30434	40308	340892	32139	32913	31104	32063	57534	429914	31404	736025	27605	29163	39823	32262	32336	30775	33266	32537	35102	26244	30314	29798	40966	30392	30661	29601	30633	27779	31297	32629	26495	46267	633698	34871	34243	718044	633825	70421	639382	28589	597034	35333	414070	168897	866916	916140	436781	58358	31256	39167	545430	27948	586928	37321	747061	941019	652880	65118	509520	29542	348306	69251	560429	225016	898501	942881	1090410	41024	689426	83104	945649	63727	31602	193718	769878	791975	640070	391655	666115	41276	776370	61607
Phosphoserine	237655	4937	220335	707	3885	2813	5901	1218	2108	23731	77139	2636	1315	1047	2737	2939	7209	848	1705	4217	1905	83548	1684	280627	1129	1071	2140	1322	2770	757	1400	205591	722	445312	4839	533	1157	782	641489	999	201340	205942	1929	121899	487562	854	614001	898	713	1528	1016	3166	664	728	1769	1657	394272	806	2487	1071	1528	1640	3918	1893	1873	1511	768	933	12312	7649	236499	99737	951	2261	1637	1889	1340	1693	2048	1192	1076	893	2256	2025	828	1937	1332	1108	2643	1273	2038	744	708	1251	1450	2173	1289	511	702	589	152821	985	256007	0	373463	0	406952	9715	709172	738	104569	1171	194846	55640	629	506	37797	1829	1178413	706	1071	1081	1187	559	689	1202	623956	857	819605	6481	267196	1175	2959	0	1703	878	1016	701	892	682	203846	99850	822	345101	956	896	636	599	1221	681	198055	2386	414	1108	1018	875	761	707	932	96978	1687	542	594	607	0	229761	1224	578776	704	645	1129	1024	486	917	1103	1912	1210	541	1578	549	1989	827	576	981	465	665	778	3696	570	1067	734912	3837	2522	217104	1206148	507	616931	711	761386	2998	188524	90027	303462	167714	239100	632	0	1164	986485	663	174025	5002	275173	301798	710044	1564	485010	0	396109	0	160360	99567	235884	222038	765997	2952	489999	996	813480	0	969	76380	153178	197517	644791	0	582511	2801	903806	0
L-Citrulline	387129	16431	241312	686	134252	13011	35336	27834	578	109008	130635	522	442	3803	80115	31011	100506	1154	629	45700	1004	16795	1605	128023	892	2323	5917	4556	2404	15646	496	316518	1074	242030	14220	12890	2836	1192	2788547	5541	184039	191489	24491	252294	2016779	2152	2747156	613	1291	10120	810	13304	10932	1431	555	1611	3238134	733	485	3751	2259	4082	5129	792	1016	940	6517	741	195352	35028	210630	83765	504	524	5458	607	799	706	2173	651	2880	608	455	589	1955	6245	2376	35530	9986	3955	768	1749	2422	1262	876	925	1827	8949	8628	2161	210094	2891	441361	2344	2198391	75881	2347517	64912	3564942	6666	220387	996	386520	189256	2230	16907	206792	42526	3526277	2088	1862	639	7453	2582	7365	710	186163	5737	209457	78924	198626	7003	3421	2903	34891	9388	4771	1087	4381	1267	278092	62446	1175	451013	415	4685	563	5388	9960	1068	181587	7197	3575	4051	2725	590	1866	7070	13614	146690	10946	8248	565	413	1192	217554	597	243362	7013	1906	504	649	2926	3066	751	983	1570	5950	2146	1421	12498	5990	573	1196	1077	2256	2757	47300	24794	22495	461320	9551	10203	476249	444030	24131	359603	2728	397398	6491	127178	31542	316852	265932	119842	1536	7357	635	189025	3943	190463	14364	390729	378526	193478	1224	146373	0	129689	32919	228042	106928	323219	361754	408134	16624	251156	34695	400118	7349	3044	35787	402874	326367	208902	26497	210655	7003	297689	9083
Spermidine	1887361	1997920	4712668	6137	158129	191834	135623	254674	5302	23218	2986994	9956	6851	28434	236140	68141	167983	184052	15180	88321	6445	6155820	13682	4991430	44412	24178	41949	28936	7406	270488	4941	1327104	7327	10102179	70278	364036	10204	21647	4569122	53252	4253804	7377451	76843	319641	12981192	8912	11020776	15378	8200	9861	12453	57786	17618	15768	4655	24540	9618430	23940	5252	34696	42669	9050	40225	18903	28500	24845	12957	12068	1212370	20737	7125533	5633838	10872	37377	17540	23031	17267	16493	11749	8755	13504	5732	6116	49133	20415	93807	82766	72461	49934	6268	5021	7888	15320	7266	7460	4588	6549	9159	8486	5404	4713842	11869	1392000	21195	4766005	831257	5527472	67611	6602828	18576	9870852	4844	1273436	852569	6408	199374	1731949	435755	7019071	11452	4740	6386	7402	92627	5964	5483	7624272	15850	6455483	37273	5445571	39136	50216	10011	13297	9009	9027	4662	5319	4264	7555712	7132776	10481	2039823	3789	7386	2915	5309	126559	6555	5836480	89457	5365	6300	4219	5002	11855	15437	12332	3622475	64951	18127	4474	4025	153238	6181894	95721	8208616	4888	7767	6056	9134	4999	5832	5030	4177	7235	38161	6672	4526	17144	16324	5754	4730	3917	13194	6671	32055	10386	28624	5350534	21448	16076	778610	1847663	220966	4162676	22476	5185118	45302	6272923	5224509	750342	1005140	6150307	217198	98544	2560	4078942	38218	5809668	16403	1290051	1309627	4191636	183954	3598229	124066	5761307	468765	6714855	6492034	813656	1221170	6940688	18619	5623572	393962	4876037	72953	5039	9160645	1517545	1447949	7330821	354042	7384945	64709	7905953	275289
Creatine	3510301	1186067	4568182	3091	1030557	191329	705651	737214	1225	20977350	2070203	1668	2979	32239	678561	106252	854543	167343	27167	205485	1972	5935680	7336	12304257	21301	21794	24480	20190	4354	1113978	3628	5799943	6802	9819985	155881	1326936	16738	7862	7102108	76025	5248243	5686516	37315	2871051	4896934	10163	4644084	5356	4877	97284	14534	19548	54505	8780	2204	27990	7125948	27417	1553	18878	30511	12246	11039	12877	10873	6151	32818	47175	349179	289350	6893316	4708135	6128	4086	20287	4333	21563	8207	11232	4067	10983	3202	1955	7337	15465	35932	35684	54467	15378	30557	2170	12863	17091	5425	7063	1303	6884	50632	71179	6854	11157986	8452	10395819	30728	11638471	588390	10305633	145432	15889628	71359	7732851	1781	6660625	5165646	10389	154276	2523902	115883	10568308	18210	7898	5738	34107	59758	16277	4336	5185835	36637	5746749	189748	4671549	141298	47664	8027	72622	39369	21693	6376	9339	4428	11707113	8033064	15690	8189771	718	15232	4725	23955	190538	4283	4898822	89380	18815	21702	14022	2460	16568	32495	42109	3765543	56896	37755	3751	1689	522786	4583136	254627	6500621	39011	5004	2087	14305	11102	15904	2700	2302	13381	53502	7024	5391	130744	57356	4720	3126	7685	18054	10021	136550	38228	153010	13772497	190552	120978	6755685	10538183	1552833	10014119	65696	12113521	160163	6296686	3961193	3701046	4109553	4920434	453454	168403	3323	6601541	57656	7331250	151551	4151879	4238906	7643852	887720	5485719	484115	5871978	2312535	10324341	6176212	10091850	10358889	15565235	223021	10685017	1999519	12294363	913906	12115	4707823	8398704	8001508	7510730	1957035	7822414	105106	9332327	750884
Creatinine	12407261	49833	6887020	16456	4466982	117619	951100	255711	13470	10588404	4738309	21278	13319	34914	2291311	95576	3688229	88438	45757	66886	13535	74197	23475	1780951	24380	28595	84806	23169	21581	153683	12599	13582925	45855	3145724	33431	15588	36031	10624	2679151	46322	3777207	3177274	54314	10702174	1994614	26543	2065924	17494	40385	207260	27534	29118	68923	28684	13348	28816	3028400	26595	13025	44933	59009	18201	22170	19421	34672	32911	123335	69182	112404	183751	5276763	261327	18538	26148	50136	25234	52763	16162	48888	13114	32292	16856	13018	16676	22724	88060	34994	47837	26427	89575	12213	54927	23017	27995	21605	13337	23165	36005	107394	21431	4449090	25511	13578239	54646	1984475	85779	2276718	72891	3388650	44985	5259952	13349	14509080	11753412	19532	33648	722836	27058	3718393	27073	19523	18654	32102	39396	23457	16454	2923136	50330	3461506	63974	4759630	67685	45139	12587	35763	54036	32775	19821	18383	13034	4262404	191080	25736	10504153	15381	32475	16768	45015	151351	16021	5503204	82111	36493	27445	19457	14813	23677	39444	36398	3867038	60442	49362	16455	12774	291904	3367228	64047	3011387	67008	12465	19375	22884	27034	30747	13607	16273	24531	65848	21625	18259	163163	86350	16195	14296	17288	35119	23518	52724	27356	46857	5593319	152602	65776	12277837	3404880	342191	4403700	42933	4790066	60928	4445356	152736	10213179	8945189	2297954	127676	82572	18888	3577841	46080	5300350	209700	15461256	15884045	2789810	165538	2192567	118452	3413071	489925	4112892	286840	9503321	8176142	2664988	227634	2219795	396854	2606819	133864	24958	244929	9490871	9114111	2476615	978844	2330387	122696	3268060	180731
N-Acetylornithine	198996	108190	540473	1371	105053	4308	46500	19062	1377	26003	186251	883	1008	2267	37345	5089	65581	886	1775	6382	651	174696	2084	1901018	2488	2112	3593	2932	832	20176	1602	173912	2553	707902	3525	38728	1548	2431	369802	3759	147832	255077	2629	43272	1976144	1527	1561361	1595	2180	2113	2435	2554	2643	2377	1081	1876	1152055	1849	1311	3346	2541	2301	2247	2297	2432	2091	1445	2630	13471	15828	568915	364132	739	2242	1857	1985	2090	1326	786	1395	1887	1987	870	1147	2538	3923	2191	4132	3402	2471	1525	2010	1828	1740	1114	770	2338	843	854	869	431183	1388	224721	1539	649364	14043	1567785	5053	1918273	860	462027	1779	157206	54234	1439	3319	453413	13250	1810326	2393	1799	1309	964	2800	1553	1599	1737144	1626	1393243	3132	1206884	1469	3836	842	2386	1323	899	716	730	1400	572092	212396	1950	382777	1237	1339	636	2532	3010	763	510086	4696	2041	618	798	976	1373	1425	1678	141781	1882	1883	1191	2113	1065	577430	2092	1431145	3145	911	804	2340	1657	1216	597	1287	743	2145	967	656	3926	3424	792	673	1294	1390	1878	2271	1551	4796	822293	4696	5074	288902	407119	36801	959439	2049	943826	2986	857191	544243	70826	208694	263039	1836	2030	1570	661970	3373	400659	3571	304903	528297	627270	13341	258574	4217	738031	15117	365192	192194	57708	127985	790962	3863	390037	33250	248954	1399	1235	175521	197917	190462	942745	7073	848407	4208	971255	11040
Pantothenate	1093855	162648	762172	579	78989	32537	6525	50556	603	121790	723265	1963	813	2151	43068	1538	95314	14940	1391	2567	1371	174731	1430	316305	1068	822	2717	1381	916	22303	622	606784	816	455283	6386	35772	774	4085	252377	933	981486	1002020	2559	379486	930282	1539	970473	1576	1333	2244	1470	2932	1550	1177	861	1038	915466	1261	601	1156	796	1189	1439	1141	1141	1614	1406	1110	35341	5100	676611	223988	945	2148	2579	1897	2241	1520	656	823	791	1746	1396	2326	834	2332	802	2067	1982	723	679	733	734	629	1072	655	1157	689	842	546	411528	547	1243135	1969	202873	25515	332988	2532	385076	577	916271	832	2157232	735152	950	1540	170199	11489	1416505	737	0	758	504	786	477	982	818767	720	1099003	658	1016736	626	828	610	627	1186	1019	957	454	709	562613	590646	608	1091492	503	869	596	422	601	743	977568	1618	525	1091	1280	1114	1164	1009	554	646242	695	931	731	588	11624	953690	24201	1357638	736	467	1696	685	1069	530	1208	0	491	655	993	753	655	971	600	653	411	0	1304	816	636	8017	540533	1141	723	307595	265967	21604	600024	477	668961	862	1164553	409492	1079167	633387	484030	9855	749	0	567398	626	825204	3553	807939	922700	606577	15835	411827	12428	584114	56823	1015077	1035327	675956	888146	829150	907	461451	43291	603624	11858	713	302869	859757	872192	1508090	37000	1116280	1535	960659	38140
3-Methyleneoxindole	4146129	403299	1986703	4370	710586	112868	41864	100345	3186	21598	2151679	6710	5109	5135	106192	3955	320397	65792	5537	2847	3939	618714	4084	1307121	4689	5559	6714	4169	4639	54114	5043	1348031	9093	703201	6139	54720	6911	7075	451599	6567	1326868	2116481	2417	1285234	1487894	5280	1049316	4892	7035	8861	6654	6380	5434	5729	3417	3275	1030864	5792	3622	7758	4518	6419	6065	6843	4686	4048	4366	4764	19614	19881	1939821	1054248	6086	8475	6342	5393	1794	6238	7226	3961	7650	5069	5366	4677	5469	5211	3646	3533	6384	4965	5043	4957	4123	6061	6439	4699	4825	5507	5647	5934	1375543	5425	3866764	6175	573862	50043	1684549	6334	1278275	4202	2467303	3874	4545063	2045005	5648	7045	224805	41077	1336713	8907	4671	4124	4946	2805	5969	3998	1953504	6076	1836238	5718	1635592	5403	4322	4094	4876	4281	6040	5506	5439	4124	1430159	708179	5514	4623504	3502	5032	4329	7286	6072	4289	1460161	4450	5377	4566	5324	2437	4367	4447	6114	1581425	5430	4424	4726	3953	5765804	3400066	7231484	2954360	7782	2466	4288	4519	4734	6175	6017	3508	8441	2570	4020	3583	7696	5148	4233	5577	3735	4058	3415	2791	2274	1774380	738537	6911	7239	1118896	415845	1520573	1126748	4766	1689691	10852	2011236	599708	5445367	1786231	2701724	3052188	6796	8592	2497823	8987	1477779	8821	2310822	2240278	1634943	1897344	1156024	3232344	2411883	2878302	1318544	630426	3382317	2093592	1901008	9658	1713577	2500121	1444991	1786411	5970	1822800	1861103	1959808	2478918	2883156	2417258	11684	2719481	4318879
Indole-3-acetaldehyde	60798612	69041024	134448592	8967	9607979	13917801	2680130	16823614	4436	2609028	125518456	15122	6952	149549	7818052	292901	9994176	4639470	34220	466946	10008	128810664	37253	161260848	72055	93722	48189	79414	15859	5535500	5478	26390136	23220	109359064	218268	17912800	42059	37555	47257008	242066	59731444	82246760	183830	3759821	90157376	35751	67783328	18195	25010	93739	17827	95869	151793	40353	6296	59690	79135784	92204	5729	102947	115709	38928	38758	48259	54395	23670	73847	54160	1606126	307179	108011264	86884200	9134	23813	89201	19619	74727	26647	33604	14933	41608	8212	7170	39193	69184	137688	82324	159288	52408	43393	7497	20555	39454	24115	19236	5052	15878	89521	75108	27267	77770888	38076	43986728	44313	45214356	2964045	110631016	401338	96033608	98351	133178752	7632	29423290	11066911	32727	167857	26546402	456822	80851872	42376	23525	37907	68066	94042	38495	10059	107729816	79072	133026048	274831	187243440	148351	219036	23488	133980	53923	34098	16794	18541	10441	74603808	66183884	109171	45090996	7862	27987	13054	25974	160036	15109	252878000	417172	46593	51660	33659	8532	38537	70066	107551	66188588	316150	48201	22243	6337	1624178	73708904	2402082	152077120	46086	15596	14392	100133	22693	35381	9619	8691	43204	68373	15834	16774	119730	42828	16222	8515	19716	34266	19085	174121	59642	665049	152216784	280492	281867	20230870	55531092	4502562	86396808	74851	135780448	240433	104637192	63284304	21737332	23899074	38960212	2498268	155410	15067	61772624	92321	139243360	155001	51395792	60414080	78394912	4995835	38587812	2989530	102135480	9326880	83229536	62849580	12479131	24646870	90211712	191512	35905116	3166752	45295620	209033	43830	105293640	36985480	28471632	93395840	3497854	89035560	264992	103453832	5543432
Indoxyl	58316	62632	136625	3811	15150	20281	6361	25818	2752	7357	117973	4114	3150	5439	11888	3963	11654	9228	3942	6775	5001	133826	4977	149444	4370	3812	5180	4742	4307	9113	3663	32774	3577	126416	6404	24367	2935	3545	50604	4130	59047	69606	5863	6605	86521	4360	60119	4325	3521	4158	4069	5171	4243	4408	3054	4062	67958	3423	4024	6060	5894	3791	6288	5318	5210	5363	4399	4278	6759	4782	109861	85925	3949	5647	4907	4597	3846	4837	4012	4076	3979	3355	3190	6742	5154	4110	2713	5898	5002	3636	4380	3030	3085	4750	4155	3322	3183	2580	1833	1544	92712	3872	45577	2836	44269	8104	127386	3262	102117	2624	123443	3214	35973	8282	3175	4227	25609	2003	84191	4506	3682	2717	3935	4964	2284	2929	90982	4424	137013	3101	214810	2879	3915	3656	3675	3437	4278	3136	3402	2941	75224	52051	3296	33771	2203	3615	3549	3088	3255	3875	250229	3301	3117	2723	3881	2939	3339	3019	3316	73271	3540	3461	3475	2454	6645	92793	8300	162183	3291	2746	3585	3219	3344	4281	2985	3637	3584	2576	3608	3113	1433	4279	3826	3391	3736	2803	2198	3424	3881	1928	163216	2523	2834	24959	63224	7300	77069	3624	139831	3568	119024	66938	31674	31047	36595	8517	4494	2780	57057	2501	131639	3964	55916	63138	74166	9894	37305	7983	106378	11089	86532	66357	18128	26022	107713	4290	37944	8079	42645	3602	3036	107865	46602	34484	83787	3390	104922	3430	93774	9340
6-Hydroxykynurenic acid	169037	189809	345704	0	14340	43973	4392	34238	0	34821	320950	0	0	559	0	0	0	0	0	948	0	383964	0	841670	0	0	1010	0	0	3810	0	86115	0	73919	837	11968	0	0	441205	0	1228861	1744769	3086	23406	492256	0	1030386	899	0	2752	0	721	0	0	0	765	531233	1355	0	668	0	0	1294	1157	655	543	0	0	22268	32691	536757	415153	687	937	661	772	0	0	0	0	0	456	0	0	767	1268	582	1324	532	0	0	0	0	0	0	0	0	673	0	0	881082	0	153325	0	296907	1028	569337	1240	342717	0	611825	0	101023	34693	0	0	14821	0	772028	0	0	0	610	0	0	0	204717	0	764197	0	843311	568	508	775	434	458	0	0	0	0	447853	224290	0	133291	0	0	0	0	2460	0	323102	462	407	0	0	0	484	0	454	446934	513	0	0	0	0	349413	0	201118	609	0	0	613	0	402	0	434	0	493	0	0	818	0	0	0	0	0	0	0	0	12455	573475	872	0	30452	352636	913	704253	0	1243696	604	598879	319638	71001	84670	48720	0	571	0	300606	0	359321	635	136216	175020	265604	0	117979	0	303607	54562	274356	238367	38165	27387	82987	755	77213	69142	76136	64531	0	579245	62294	88001	1066725	3667	376345	586	617862	0
Anthranilate	2444815	597659	3343928	9485	429641	201749	77441	160347	7548	438551	3476853	10273	8736	10608	525209	14532	607196	179191	13116	13773	8322	1938021	10222	2498178	11651	9093	12205	11516	9151	161556	8983	2384583	10476	2138727	53436	186164	9819	24449	710556	12362	2829668	3686441	11324	995449	2041195	8115	1829844	11262	9801	15493	11276	11111	11497	9617	8428	13927	1776263	14256	9187	10352	11264	10676	12779	12729	13035	11407	15792	10252	42719	45483	3766490	2155748	10186	10578	10454	10739	10295	13132	11476	8779	10883	8750	7910	10908	13376	15010	14214	15752	10936	14214	10620	8455	9444	12232	9441	8564	10535	11144	10725	7424	1967514	8551	2518907	13590	1324269	81346	2027189	25584	2250755	12028	3251461	7113	2021807	902107	8917	21487	349799	51268	2612563	9289	7031	9187	9342	10761	7043	8864	1582829	11538	2126787	13246	5049567	15078	13046	6976	9100	10090	9282	8820	7686	9687	2653968	1568083	9548	2517944	7848	8111	6906	8484	31077	6928	3449859	15960	9214	7475	8490	7833	10241	10336	12434	2287434	8831	10975	8071	8604	114778	1265270	75972	1716359	8742	8468	8023	8699	7794	7895	9109	8862	10390	15304	8152	8492	11062	6649	7013	7620	8355	9563	8539	9990	9524	39095	1945890	22929	43832	2621676	2930856	153858	2200274	9843	2414280	12883	3013671	1661451	1692306	1355420	1322817	144079	12190	8634	1845199	11396	2481097	16132	2364162	2453814	1852978	144902	1270882	83362	1645154	312691	3302095	2237264	2269618	1618041	2328509	17787	1840740	272589	2320048	100330	8428	3023630	2536843	2435353	2696082	282391	2244610	16278	2748413	157441
Picolinic acid	330230	167276	243122	9687	33970	84300	19257	56276	9678	158260	321427	12122	9199	16518	16399	14632	15211	11965	10989	15425	11129	235733	10701	225820	14936	11881	16855	14024	11845	19729	10101	157115	13314	260041	21733	11242	11213	14010	286880	14646	321273	454833	19751	204561	452167	11259	280438	14728	9975	10608	12307	16273	10187	13056	9161	10939	229784	12728	9459	15641	11742	12542	17414	9636	14530	14614	10499	12068	89924	18432	333468	273999	13453	17306	13123	16722	9826	10167	12208	9310	13077	10444	8880	16383	13974	25349	10609	22187	20569	11333	10588	12751	7158	13558	10537	10908	8663	8778	6745	8627	368451	8044	318358	8394	1586906	262970	1539082	10487	1037131	8200	394110	9936	211696	95673	8364	23835	384099	39621	1439430	9299	7373	8544	7592	10005	8496	8513	357806	11801	331318	10683	483022	8336	8012	9412	8310	10299	9635	7584	6418	8187	365202	374488	8769	380417	7810	9262	6927	7011	9573	8635	330690	8660	7544	7533	7887	9967	10265	9238	10216	277086	8322	9521	8140	8988	10208	313700	12667	376227	8859	7537	8474	7778	7674	9267	9440	9968	11157	9226	7150	8580	10723	5160	9248	10000	8545	6384	10059	12488	6674	32306	399861	8038	7567	267650	296805	17063	319665	6719	343844	6679	446707	371084	331860	341075	267679	12139	8929	9707	485124	8814	473999	7822	323059	327478	359471	27280	315397	16112	309968	30383	462512	251213	258285	358106	464182	6940	262691	59843	391538	46843	7971	288486	325505	307979	430655	19632	317701	6822	410302	14435
g-Oxalo-crotonate	1635777	2680442	3788368	1315	291698	240701	24682	155901	574	257203	2868234	492	583	10093	108451	29990	69704	127101	2892	21404	2597	1398288	4596	1722517	5766	7831	3710	5157	2702	113080	475	2348878	1598	4204356	58179	241305	7454	28919	1816519	12021	3843656	4500282	22555	104643	5913359	7468	3410669	1271	2017	11587	2944	10378	12608	5303	0	18997	3559639	10617	426	10328	9636	6167	5570	4591	5279	2036	4194	7420	115053	62457	3310154	2075435	1132	1674	11622	1410	12213	1858	1608	3282	6479	1490	485	3058	5676	15925	23288	18996	9824	7048	0	6164	13116	787	3685	530	2342	22072	9226	5684	4140929	7025	2813849	8007	2337039	581976	7117747	55676	3697358	22304	6234876	602	1171952	380882	4811	95883	1891748	111799	2984433	2267	7687	11710	13701	18439	8171	1211	3771005	16273	2342326	29067	16198715	19040	22020	3211	22877	8223	8626	4600	4738	2814	7543838	3502874	12437	3041160	2130	9172	1486	4047	16102	2212	14362097	75627	13591	18252	8603	1139	8008	12813	21466	3813330	40431	3067	5267	1732	100541	2050008	99398	6250464	3550	2700	720	13671	7990	11636	875	1111	4471	9776	4264	2480	3382	478	894	622	4609	4607	6030	22848	17120	33859	985958	7406	19766	165232	479630	614376	2148527	46694	2538842	47261	12045737	5506803	2847549	1323665	4993230	235034	61905	1215	1338639	10491	5565315	9624	1335827	2419383	1243912	131854	1237520	92504	3201371	1175392	12385616	5034943	1055052	888659	5408240	4698	1966425	535557	4141812	142843	8536	3607110	1379686	2268428	5836952	253614	2781388	11037	2323899	141731
L-Adrenaline	7838567	389131	2386035	1707	341419	19823	158875	31063	2700	274435	2297390	2532	1899	4422	245538	2329	184814	2645	2105	2858	3117	1081316	2495	1272223	2260	3549	2807	2397	1839	82625	943	5913950	1839	1410410	20763	31854	1792	2622	407410	2476	1609413	1240548	4463	8262910	586346	2349	613624	3525	2753	5186	2865	3551	2706	1998	2039	3001	762576	3083	1424	3798	3115	1617	2832	2434	2506	3566	3348	1621	81494	40211	2580769	1715208	2888	2834	3012	3104	2535	2985	2867	1251	1254	2322	2138	3102	3069	4641	2268	3813	3544	1986	2058	1779	2051	1704	2951	1747	1737	1666	1730	1877	2807841	2465	8364016	2546	966261	15159	670876	1075	1437042	1483	1723869	2767	9424373	3248273	2409	14439	116445	5275	733629	2127	1320	743	1527	2149	1452	1663	1119733	1747	833409	2020	2076131	1136	1014	2485	2583	2506	2666	1042	1348	1812	1779726	1181526	2837	7960009	1439	2362	2006	2274	4602	977	2704678	3283	1581	1611	1778	1966	1857	1653	1850	2568598	2409	3092	1436	2241	55100	1809737	53702	1309530	1739	2587	2118	1500	1489	2560	948	1509	1408	1727	1984	1372	1339	2062	1404	2601	2103	2204	1009	2076	1143	27770	1430773	3023	1034	4833605	599382	260287	1660496	2677	645936	1209	1113418	590178	6884258	2504867	1285321	38418	3802	977	684506	956	2081098	3578	7145184	6556592	1093477	107751	1035885	33418	837543	221264	3395155	1894857	7855444	4726015	2557836	7308	1271298	236387	1034933	59253	1736	1708821	5022878	5364668	1290598	288201	1339322	2097	1089570	48001
Serotonin	15329083	18678544	37373184	1823	2712570	3936775	718378	5223625	780	716599	32115446	4125	1927	38780	2339907	73877	2988289	1387402	9217	127763	2905	34715832	9216	43249504	20610	22923	13650	21835	3912	1679468	1169	7243112	6448	29503582	55946	5536458	11637	11428	12217712	52978	16191573	21015952	47884	964478	23562630	7900	18422398	5196	4670	24567	5331	24123	39708	11048	1424	14335	20747150	20940	2125	25583	29642	9553	9875	11930	15292	6839	21289	12818	462408	69032	28838994	23825232	2527	6503	22191	4902	22676	7084	8337	3203	11824	1607	1803	11485	18252	38198	19910	40539	13873	10519	2518	5639	8990	6460	4099	1859	3192	19166	19923	6173	20728114	6115	11401147	10388	11456928	813677	27505134	91719	24552322	23779	35180788	1373	7613689	3045069	8296	37962	7156329	127962	22932328	10596	5761	8075	18931	23491	9744	1764	27470056	20170	33808724	65193	45761796	36783	54112	6312	31996	12830	9006	4169	5615	2621	18907666	18290450	26679	11036760	2144	6202	2238	6877	40915	3134	70459528	110054	9876	10491	7631	1968	10414	16192	27258	18174104	75113	13591	4894	675	463490	18800234	702606	39883332	10983	2995	3504	26351	6162	7493	1702	2024	9499	14662	3442	2755	25185	8269	2456	1788	4872	6320	4981	44712	14256	201670	38698884	67463	70788	5410811	14368589	1337403	21447178	17619	31594226	62186	26822240	15661236	5630742	5980614	10004493	725593	41360	4418	15744177	26468	35304548	41203	13396484	14720881	19645246	1415937	10174981	818276	25639622	2707425	20508890	16303003	3057709	6179940	25181750	50174	9019601	881945	11893469	60066	10854	26973792	9272060	7169568	23190176	985840	21278594	62330	22227760	1609932
N-Methylethanolamine phosphate	25270256	3085534	19107858	10141	765248	50788	547224	155347	7913	553572	9675724	6903	6007	32159	490642	86480	426564	31982	15329	113637	8542	3535504	15224	8355947	24572	28443	12120	17187	17838	235311	7164	13681168	24601	5370258	83652	39347	34131	27658	5449085	44898	7933385	8107466	21404	24343554	20137784	24955	19336396	12521	22382	107400	5759	15144	70678	17449	8406	41096	6322947	43805	8410	20985	36891	21377	10811	19477	17504	12658	48478	11392	1042693	428678	7039822	3870703	6251	10030	20188	12071	24914	16592	24890	13276	19546	11016	8506	13757	18168	19531	49187	26911	13474	50540	7513	32590	27207	24485	15946	8173	17816	73746	69992	23544	7085861	28467	15817409	88687	12139008	205372	9376098	192780	19198576	110434	8054643	10307	18677926	3884928	41884	185155	3458706	314158	14596408	56852	33350	58185	66276	52448	48448	15788	11084040	62634	9611858	182687	11321604	133982	84573	35522	111897	47404	44738	35107	31607	28048	11634549	5328311	39045	22154518	16765	32052	18013	77460	174860	23609	8435443	183265	46555	45707	35074	7841	40982	46392	71827	8154845	81918	53965	11017	19137	43637	7544538	23776	11356669	72922	26389	10346	54483	32292	49152	23190	11906	52491	109400	25209	24684	93501	94681	22563	11086	21260	65975	26253	117612	86665	131574	16280872	190671	193792	12854608	6670238	271382	8672347	107929	7900079	210217	8769137	7821912	23193134	17854584	9437295	94305	191950	31418	13133900	157016	17427648	260020	23900304	26712778	13159643	156042	7873530	125703	10340545	487731	10569665	7089616	16420680	14461768	11713165	262947	6708144	440692	6910534	210023	48889	5817972	18032102	14890404	6309382	224055	6826543	191019	7216090	84261
Acetylcholine	2063556	953233	3479042	1603	1059795	189673	235379	392158	1798	554071	2777951	1604	1746	10893	455733	26770	449908	150604	1979	31729	2550	3130631	2094	2831729	4147	6907	5685	5068	2057	768397	1527	1773288	3577	5724557	26940	326909	3900	0	2360011	10488	1787473	2143617	12074	991220	3497983	3085	3458162	2790	4317	12237	1714	8456	13968	2426	2150	6566	3749147	5479	2194	6495	8181	4198	3794	1993	4770	2900	7571	4347	196394	101062	1351724	863067	2485	2254	8058	2772	7374	1234	3681	2213	2372	917	1482	4216	6442	9826	7042	12474	6698	5746	1341	2449	4231	2128	1090	1046	838	6301	6230	2097	1650514	2200	1682640	4917	1596992	96244	2126310	26376	2376968	10251	2222972	881	1469833	1014396	3365	11489	807859	9558	3296812	3961	2492	3992	5737	8221	994	1440	4201089	4901	4231315	11037	5374426	10482	15640	1609	5824	5012	4783	2453	1104	2385	3546224	2347785	5991	2680036	1655	2867	1367	2994	16760	1203	3493287	29371	3279	3736	2105	2408	3849	7731	8433	1603401	11445	5000	2249	1625	92178	3686091	81652	3464977	5348	1966	2974	5886	4179	3268	1344	1608	4269	6076	3422	1689	10166	4897	1511	1674	2202	2194	1810	11050	4020	50623	2270513	15149	11248	936745	1580268	215958	1640625	7041	2428075	13733	2109992	1839139	1312273	1458605	2724226	156199	15198	1902	2815972	6769	3508248	19259	2175372	2645412	4229335	294464	2557783	152227	4547045	386924	1799651	1489609	1362635	1143484	2446069	18001	1718244	343066	2294752	170784	3347	1758764	1632107	1495870	3638862	293088	4030398	18619	4606403	134039
Choline	40298516	14622357	53739268	17993	7054860	2313425	2025539	3823295	14580	6803786	49671632	10913	16623	86341	4575933	206665	4076966	2246783	36605	298717	12295	52046608	24522	46765392	52069	74194	62802	41819	14880	3109837	13155	69353848	35557	53543388	2982951	1927352	51542	746268	26111438	133495	86214848	126220440	125720	9828969	43773712	38586	39782868	15349	28935	260632	19999	86336	144254	35722	18043	183347	79374232	69207	13150	67311	85422	35123	47745	35636	46125	18932	79148	36368	1981748	6848542	62635740	27273000	14615	27521	58002	25701	60690	32720	38939	32824	37865	15255	16256	35062	44918	82629	245289	176301	61898	108235	14068	56889	102767	24512	23770	14312	14898	96524	78587	25316	51818092	29361	47813732	85700	31413558	1952419	55345968	364395	50673276	136932	67134120	15664	34449360	11609336	37556	618435	18047544	1356636	97289440	48901	28231	47202	82311	87826	38244	16366	51712492	72683	72861976	276137	23052138	248866	167910	26753	131745	74180	45659	28298	29212	26407	45579552	52254804	67929	47567840	11219	31044	11379	40966	313818	20791	22843386	199389	44366	53775	36978	18428	35903	93057	107740	37170548	91441	74751	19530	16205	5750219	43507364	6032134	55607132	55266	25883	13207	65917	24845	49860	20964	10086	63794	127952	38121	18036	116294	62814	19632	19517	26652	47040	25869	219320	81792	4128246	47956496	325269	282853	53381788	30839718	5683707	56064948	69531	62814388	247399	76990536	75499032	27952790	41368664	42950444	5187705	158244	24407	79626296	119025	52613044	302793	41516416	57289536	61835548	4904010	54782080	5033258	52687980	8666637	21925888	37960488	27673680	44930176	60375084	274134	52079988	9360441	81961976	6812636	35600	59187820	52691744	71205144	78591168	5492215	84348896	275101	96565032	6601530
L-Carnitine	25776934	3032753	20369200	6845	13079311	727924	1461447	1079530	3012	2992312	14942875	5244	5558	38697	5363814	140532	7002089	526499	19346	133547	5687	7705640	16482	10284735	40467	30489	65357	22534	14536	1448362	4522	25993482	35300	24207592	89176	847178	43082	9799	7839330	79510	14786088	18062982	62912	33338678	14631904	33381	13873179	8656	29575	320213	9624	27956	98534	22733	2599	42422	15852696	61792	2690	57643	63321	27560	14597	28632	33374	21439	115064	22700	734929	756642	23731270	12670435	4115	14824	58576	16385	48533	18441	38151	9178	22709	6931	3565	11993	22721	106577	61375	67381	24671	128758	3580	58746	35019	13901	13082	3180	10615	68280	132721	13151	21534976	17852	32136216	47758	12651736	585568	15776439	195490	19708280	110536	16870378	5236	24464350	22626560	23517	101677	4391144	90484	19462678	36572	15140	12288	61571	62097	16324	6600	21526784	65487	16920082	153592	31176762	147296	62725	9915	66178	53153	35365	11976	11157	10125	22250826	8610020	29106	35375540	3803	24076	7805	59303	193741	4298	30647482	230888	38696	36667	22310	4309	25247	67742	49556	21672918	115268	49013	8855	6225	1476294	31786354	1047655	24171954	77284	4673	3368	32704	22758	37266	4551	3804	35482	76750	13717	10142	198474	103762	8660	5005	14184	22753	16038	118383	37798	224731	18888442	290301	183884	26147392	17298692	2311998	22622008	101452	13793561	202837	15009957	4942983	26748118	14621121	17781940	835491	257769	5550	14401720	85466	28011934	275355	29228734	28148384	25879136	1611435	16418687	928435	24567494	4404392	32350672	15025769	33630748	26792014	40415968	340131	20718122	3573327	20455462	567288	28829	13532813	28307714	34435932	30640288	5127068	32474710	195106	30055568	1484568
acetyl-carnitine (acyl-C2)	11698816	3559865	16758512	4598	5329014	483703	871702	1148123	2841	986818	19557174	5384	3243	22439	2492343	101245	2661876	258823	8266	124961	4145	8236545	10981	21741240	31487	16586	22886	21329	7794	1730834	3687	9751973	14841	11151529	72072	1343859	14492	3620	7494950	41907	7609652	10155628	40666	11609029	14369589	11830	14826073	8450	15166	104980	6307	30994	53896	11537	3243	20536	23691394	52012	2947	33713	28764	16041	18279	24779	18590	10559	43334	16176	326516	476969	35138420	18656578	4573	9547	23170	9162	25338	12298	16726	5815	13675	5966	3013	12840	12182	49191	26126	73800	26490	31467	3936	17460	14047	8336	7811	2861	5209	45262	67152	8158	33097898	10380	36305188	37407	14319427	440826	24127430	68660	21295804	75204	27259214	3303	18447398	7929462	18148	59409	4028799	48970	12152507	17072	10195	11161	31028	32516	13665	4400	6497951	28238	12332247	74730	9247417	95101	43005	6710	41752	23548	15347	10084	6514	7443	18000194	9171720	17875	20151160	3318	14477	3898	21302	166464	3693	5251661	64164	19267	23826	10409	4228	14475	31361	22685	16674111	22778	22926	6119	3769	646287	22678158	389864	22213008	31036	4863	1641	17200	10969	17914	5130	2942	22548	51863	9029	4762	80038	32609	6141	2620	9448	17596	9577	67568	26363	125605	60693296	198010	145314	16854694	20711056	1194085	22471270	37072	47792976	33938	21894704	10740494	22435584	18395584	3703982	342351	75940	3785	9466989	51546	24790082	153869	19417478	33576036	22763728	749172	14826581	470010	16649311	2113363	12668347	15326976	11643840	11708611	4686369	175738	6698793	2235043	16901620	1077478	11746	11446588	23459896	15786348	22536440	1547998	23161488	107021	33238296	934591
acyl-C4-OH	311455	763337	2013426	430	161891	29040	11958	115793	0	27975	1476688	1802	830	1542	49695	6777	56258	42969	729	10861	0	780341	683	2203620	1486	611	1566	1507	436	87845	470	149974	755	625444	1855	62908	611	3082	412646	1794	614670	1030949	1815	115549	3683152	508	3552865	875	1638	1688	754	2557	4479	559	0	734	3759491	809	441	1578	2074	1276	1638	869	851	695	576	761	70112	20537	960417	665307	548	1584	1589	881	1007	626	727	0	589	502	807	1864	1154	2128	2063	4580	1542	531	581	549	528	660	689	635	509	2374	1138	0	2187719	576	1094998	0	2114269	49065	5755565	4707	2898155	3312	1342780	0	371460	189916	454	566	348737	3986	1215035	1259	0	0	662	2087	0	0	644047	0	1112458	3845	2058556	4885	2769	0	2383	1582	624	670	0	0	2051345	1207412	668	357271	0	632	0	0	4470	0	538361	4396	576	1326	0	0	0	1277	572	881698	614	744	0	0	29631	1369875	38284	3634941	625	566	0	520	695	724	0	0	485	616	486	493	1098	0	550	0	513	0	471	3125	439	14361	3043439	5213	8968	290638	2858599	97833	3512329	1717	7342582	1676	1347278	554094	246285	357327	423209	11609	1286	0	906547	3039	2019578	2715	411697	893543	2782485	221293	1311397	88761	1918478	179409	1616211	464508	187257	218347	728131	2666	819266	102964	1239077	33426	400	1399620	767826	242165	1903964	213787	3887640	5880	3231311	99244
acyl-C5:1	91769	74555	134156	1272	6207	7285	3887	9584	1288	2631	52306	867	854	2151	3789	1835	2311	5867	1258	3040	1456	99215	2402	113868	1156	2063	2248	1764	1117	1964	1447	13193	1180	191830	5047	7990	1401	4134	28535	2563	79627	198406	3073	3583	579798	2169	235818	2636	2190	1073	1847	2748	1081	1945	774	1752	136909	2292	860	2882	1960	1021	1891	2015	1381	2280	2044	1717	1898	3293	127869	57492	2434	2713	3569	2137	1103	1311	1021	749	1956	1266	2002	2577	2491	2786	1038	2242	3519	2198	797	1957	1158	1607	1550	926	1861	644	1559	727	90215	1032	124634	612	129445	4110	392129	762	325994	730	282226	872	51072	2253	776	1521	44412	5826	312942	810	592	1045	848	949	1107	719	550530	1376	472762	889	524597	910	694	742	926	1411	846	1316	723	1120	104503	93101	930	109078	654	860	653	668	1098	737	216118	783	704	667	743	620	1700	1486	832	61880	937	727	516	1353	3043	115972	2746	711875	592	678	1050	1331	2107	1501	1099	1259	773	873	1006	835	2251	2092	1420	1366	869	826	875	1319	873	6038	115716	1242	1574	32588	54330	10761	209537	802	386289	3397	446837	86618	12420	38542	289691	4972	2056	762	450121	594	60598	1127	113287	183789	215351	5733	144533	4220	294493	14987	88443	203972	9747	30982	680303	0	197135	12759	132007	0	576	77185	50285	56756	414581	3502	253188	1239	354103	4497
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	KEGG ID	m/z	r.t. (min)
L-arginine	C00062	175.1187	0.1930
L-lysine	C00047	147.1131	0.1810
L-valine	C00183	118.0863	0.2190
Adenosine	C00212	268.104309	0.36
Adenine	C00147	136.062149	0.274
Uracil	C00106	113.035118	0.317
IDP	C00104	429.024139	0.257
5-Hydroxyisourate	C11821	185.03241	0.205
5-6-Dihydrothymine	C00906	129.066299	0.235
4-Pyridoxate	C00847	184.058472	0.189
Nicotinamide	C00153	123.055191	0.271
D-Ribose	C00121	151.061935	0.294
S-Glutathionyl-L-cysteine	C05526	427.091431	0.188
(5-L-Glutamyl)-L-glutamine	C05283	276.118896	0.223
Dimethylglycine	C01026	104.070862	0.248
Phosphoserine	C02532	186.017776	0.193
L-Citrulline	C00327	176.102783	0.217
Spermidine	C00315	146.165329	0.219
Creatine	C00300	132.076675	0.207
Creatinine	C00791	114.066444	0.21
N-Acetylornithine	C00437	175.108124	0.24
Pantothenate	C00864	220.117599	0.441
3-Methyleneoxindole	C02796	146.060165	0.63
Indole-3-acetaldehyde	C00637	160.075607	0.373
Indoxyl	C05658	134.060287	0.379
6-Hydroxykynurenic acid	C08480	206.046646	0.265
Anthranilate	C00108	138.054153	0.203
Picolinic acid	C10164	124.039551	0.2
g-Oxalo-crotonate	C03453	159.027512	0.228
L-Adrenaline	C00788	184.095917	0.169
Serotonin	C00780	177.101868	0.377
N-Methylethanolamine phosphate	C01210	156.042603	0.181
Acetylcholine	C01996	146.11734	0.2
Choline	C00114	104.10743	0.191
L-Carnitine	C00318	162.11293	0.19
acetyl-carnitine (acyl-C2)	C02571	204.123398	0.221
acyl-C4-OH	HMDB13127	248.148849	0.264
acyl-C5:1	HMDB02366	244.153564	0.364
METABOLITES_END
#END