#METABOLOMICS WORKBENCH narjar_20250528_200008 DATATRACK_ID:5959 STUDY_ID:ST003947 ANALYSIS_ID:AN006488 PROJECT_ID:PR002469 VERSION 1 CREATED_ON June 4, 2025, 2:05 am #PROJECT PR:PROJECT_TITLE Higher Plasma Kynurenine to Tryptophan Correlates with Increased Incidence of PR:PROJECT_TITLE Mild Cognitive Impairment in Treated Metabolic Syndrome Patients PR:PROJECT_TYPE MS quantitative analysis PR:PROJECT_SUMMARY An increase in cognitive impairment has been observed in metabolic syndrome PR:PROJECT_SUMMARY (MetS) patients. Although alterations in metabolomic profiles have been PR:PROJECT_SUMMARY identified as potential plasma/serum biomarkers of mild cognitive impairment PR:PROJECT_SUMMARY (MCI) and MetS, findings remain inconsistent— likely due to the heterogeneity PR:PROJECT_SUMMARY among MetS patients and the lack of subsequent validation using targeted PR:PROJECT_SUMMARY analysis after initial untargeted analysis. In this study, we validated mass PR:PROJECT_SUMMARY spectrometry-based quantitation methods and quantified amino acids, fatty acids, PR:PROJECT_SUMMARY and tryptophan metabolites in the kynurenine pathway in plasma of ninety-five PR:PROJECT_SUMMARY treated MetS patients with and without MCI assessed by Montreal cognitive PR:PROJECT_SUMMARY assessment. We found that MCI was positively associated with kynurenine to PR:PROJECT_SUMMARY tryptophan ratio (KTR) after the adjustment for age, gender, and BMI, as well as PR:PROJECT_SUMMARY were negatively associated with C20:3 [all-Z-8,11,14] and lysine. One-unit PR:PROJECT_SUMMARY increase in KTR resulted in increased probability of developing MCI by 371%. In PR:PROJECT_SUMMARY contrast, one-unit increases in C20:3 and lysine were associated with decreased PR:PROJECT_SUMMARY odds of developing MCI by 81% and 78%, respectively. Our finding underscores the PR:PROJECT_SUMMARY prominent neuroinflammation, beyond normal aging, in MetS patients, even under PR:PROJECT_SUMMARY ongoing clinical treatment. It also points to the potential of KTR as a risk PR:PROJECT_SUMMARY marker for MCI, offering a valuable complement to the existing cognitive PR:PROJECT_SUMMARY assessments that may be influenced by educational background. In addition, the PR:PROJECT_SUMMARY validated metabolite data is an useful resource for future research. It can PR:PROJECT_SUMMARY facilitate comparisons across different studies, contribute to large-scale PR:PROJECT_SUMMARY analyses, and be used in machine learning models for discovering and validating PR:PROJECT_SUMMARY new biomarkers. PR:INSTITUTE Mahidol University PR:DEPARTMENT Faculty of Medicine Siriraj Hospital PR:LABORATORY SiCORE-MSB PR:LAST_NAME Jariyasopit PR:FIRST_NAME Narumol PR:ADDRESS 2 Prannok, Bangkok, Non-US, 10700, Thailand PR:EMAIL narumoljariyasopit@gmail.com PR:PHONE 662-4195507 #STUDY ST:STUDY_TITLE Total fatty acids in plasma of treated metabolic syndrome patients with and ST:STUDY_TITLE without mild cognitive impairment ST:STUDY_SUMMARY n this study, we validated mass spectrometry-based quantitation methods and ST:STUDY_SUMMARY quantified total fatty acids in plasma of ninety-five treated MetS patients with ST:STUDY_SUMMARY and without MCI assessed by Montreal cognitive assessment. ST:INSTITUTE Mahidol University ST:DEPARTMENT Faculty of Medicine Siriraj Hospital ST:LABORATORY SiCORE-MSB ST:LAST_NAME Jariyasopit ST:FIRST_NAME Narumol ST:ADDRESS 2 Prannok, Bangkok, Non-US, 10700, Thailand ST:EMAIL narumoljariyasopit@gmail.com ST:PHONE +6624195500 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 SU:GENDER Male and female SU:HUMAN_ETHNICITY Thai #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - NC-001 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-001.mzML SUBJECT_SAMPLE_FACTORS - NC-002 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-002.mzML SUBJECT_SAMPLE_FACTORS - NC-003 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-003.mzML SUBJECT_SAMPLE_FACTORS - NC-005 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-005.mzML SUBJECT_SAMPLE_FACTORS - NC-008 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-008.mzML SUBJECT_SAMPLE_FACTORS - NC-009 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-009.mzML SUBJECT_SAMPLE_FACTORS - NC-010 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-010 comc.mzML SUBJECT_SAMPLE_FACTORS - NC-011 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-011.mzML SUBJECT_SAMPLE_FACTORS - NC-012 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-012.mzML SUBJECT_SAMPLE_FACTORS - NC-013 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-013.mzML SUBJECT_SAMPLE_FACTORS - NC-020 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-020.mzML SUBJECT_SAMPLE_FACTORS - NC-021 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-021.mzML SUBJECT_SAMPLE_FACTORS - NC-022 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-022.mzML SUBJECT_SAMPLE_FACTORS - NC-023 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-023.mzML SUBJECT_SAMPLE_FACTORS - NC-024 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-024.mzML SUBJECT_SAMPLE_FACTORS - NC-025 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-025.mzML SUBJECT_SAMPLE_FACTORS - NC-026 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-026.mzML SUBJECT_SAMPLE_FACTORS - NC-029 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-029.mzML SUBJECT_SAMPLE_FACTORS - NC-031 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-031.mzML SUBJECT_SAMPLE_FACTORS - NC-033 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-033.mzML SUBJECT_SAMPLE_FACTORS - NC-034 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-034.mzML SUBJECT_SAMPLE_FACTORS - NC-035 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-035.mzML SUBJECT_SAMPLE_FACTORS - NC-036 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-036.mzML SUBJECT_SAMPLE_FACTORS - NC-037 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-037 conc.mzML SUBJECT_SAMPLE_FACTORS - NC-038 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-038.mzML SUBJECT_SAMPLE_FACTORS - NC-039 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-039.mzML SUBJECT_SAMPLE_FACTORS - NC-040 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-040.mzML SUBJECT_SAMPLE_FACTORS - NC-041 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-041.mzML SUBJECT_SAMPLE_FACTORS - NC-042 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-042.mzML SUBJECT_SAMPLE_FACTORS - NC-043 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-043.mzML SUBJECT_SAMPLE_FACTORS - NC-044 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-044.mzML SUBJECT_SAMPLE_FACTORS - NC-045 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-045.mzML SUBJECT_SAMPLE_FACTORS - NC-046 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-046.mzML SUBJECT_SAMPLE_FACTORS - NC-047 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-047.mzML SUBJECT_SAMPLE_FACTORS - NC-048 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-048.mzML SUBJECT_SAMPLE_FACTORS - NC-049 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-049.mzML SUBJECT_SAMPLE_FACTORS - NC-050 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-050.mzML SUBJECT_SAMPLE_FACTORS - NC-051 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-051.mzML SUBJECT_SAMPLE_FACTORS - NC-052 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-052 conc.mzML SUBJECT_SAMPLE_FACTORS - NC-053 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-053.mzML SUBJECT_SAMPLE_FACTORS - NC-054 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-054.mzML SUBJECT_SAMPLE_FACTORS - NC-055 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-055.mzML SUBJECT_SAMPLE_FACTORS - NC-056 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-056.mzML SUBJECT_SAMPLE_FACTORS - NC-057 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-057.mzML SUBJECT_SAMPLE_FACTORS - NC-058 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-058.mzML SUBJECT_SAMPLE_FACTORS - NC-059 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-059.mzML SUBJECT_SAMPLE_FACTORS - NC-060 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-060.mzML SUBJECT_SAMPLE_FACTORS - NC-061 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-061.mzML SUBJECT_SAMPLE_FACTORS - NC-062 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-062.mzML SUBJECT_SAMPLE_FACTORS - NC-063 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-063.mzML SUBJECT_SAMPLE_FACTORS - NC-064 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-064.mzML SUBJECT_SAMPLE_FACTORS - NC-065 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-065.mzML SUBJECT_SAMPLE_FACTORS - NC-066 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-066.mzML SUBJECT_SAMPLE_FACTORS - NC-067 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-067.mzML SUBJECT_SAMPLE_FACTORS - NC-068 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-068.mzML SUBJECT_SAMPLE_FACTORS - NC-069 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-069.mzML SUBJECT_SAMPLE_FACTORS - NC-070 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-070.mzML SUBJECT_SAMPLE_FACTORS - NC-071 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-071.mzML SUBJECT_SAMPLE_FACTORS - NC-072 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-072.mzML SUBJECT_SAMPLE_FACTORS - NC-073 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-073.mzML SUBJECT_SAMPLE_FACTORS - NC-074 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-074.mzML SUBJECT_SAMPLE_FACTORS - NC-075 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-075.mzML SUBJECT_SAMPLE_FACTORS - NC-076 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-076.mzML SUBJECT_SAMPLE_FACTORS - NC-077 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-077.mzML SUBJECT_SAMPLE_FACTORS - NC-078 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-078.mzML SUBJECT_SAMPLE_FACTORS - NC-079 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-079.mzML SUBJECT_SAMPLE_FACTORS - NC-080 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-080 conc.mzML SUBJECT_SAMPLE_FACTORS - NC-081 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-081.mzML SUBJECT_SAMPLE_FACTORS - NC-084 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-084.mzML SUBJECT_SAMPLE_FACTORS - NC-085 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-085.mzML SUBJECT_SAMPLE_FACTORS - NC-086 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-086.mzML SUBJECT_SAMPLE_FACTORS - NC-087 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-087 conc.mzML SUBJECT_SAMPLE_FACTORS - NC-089 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-089.mzML SUBJECT_SAMPLE_FACTORS - NC-092 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-092.mzML SUBJECT_SAMPLE_FACTORS - NC-093 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-093.mzML SUBJECT_SAMPLE_FACTORS - NC-094 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-094.mzML SUBJECT_SAMPLE_FACTORS - NC-095 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-095.mzML SUBJECT_SAMPLE_FACTORS - NC-098 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-098.mzML SUBJECT_SAMPLE_FACTORS - NC-099 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-099.mzML SUBJECT_SAMPLE_FACTORS - NC-100 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-100.mzML SUBJECT_SAMPLE_FACTORS - NC-101 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-101.mzML SUBJECT_SAMPLE_FACTORS - NC-102 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-102.mzML SUBJECT_SAMPLE_FACTORS - NC-103 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-103.mzML SUBJECT_SAMPLE_FACTORS - NC-104 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-104.mzML SUBJECT_SAMPLE_FACTORS - NC-106 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-106.mzML SUBJECT_SAMPLE_FACTORS - NC-107 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-107.mzML SUBJECT_SAMPLE_FACTORS - NC-108 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-108.mzML SUBJECT_SAMPLE_FACTORS - NC-110 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-110.mzML SUBJECT_SAMPLE_FACTORS - NC-111 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-111.mzML SUBJECT_SAMPLE_FACTORS - NC-112 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-112.mzML SUBJECT_SAMPLE_FACTORS - NC-113 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-113.mzML SUBJECT_SAMPLE_FACTORS - NC-114 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-114.mzML SUBJECT_SAMPLE_FACTORS - NC-115 Sample source:plasma | Factor:MetS RAW_FILE_NAME(Raw file name)=NC-115.mzML SUBJECT_SAMPLE_FACTORS - NC-116 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-116.mzML SUBJECT_SAMPLE_FACTORS - NC-126 Sample source:plasma | Factor:MetS-MCI RAW_FILE_NAME(Raw file name)=NC-126 conc.mzML #COLLECTION CO:COLLECTION_SUMMARY Blood was collected in EDTA-coated tubes and centrifuged at 3,000 rpm to obtain CO:COLLECTION_SUMMARY plasma. The plasma was then transferred into cryovials and stored at –85°C CO:COLLECTION_SUMMARY until use. CO:SAMPLE_TYPE Blood (plasma) #TREATMENT TR:TREATMENT_SUMMARY All patients were divided into two groups: 1) MetS patients with MCI and 2) MetS TR:TREATMENT_SUMMARY patients with normal cognitive function. MCI was determined when the MoCA score TR:TREATMENT_SUMMARY was less than 23. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Sample preparation is provided in the protocol file. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE GC CH:INSTRUMENT_NAME Agilent 7890B CH:COLUMN_NAME Agilent DB-FastFAME (30 m, 0.25 mm, 0.25 um) CH:SOLVENT_A n/a CH:SOLVENT_B n/a CH:FLOW_GRADIENT n/a CH:FLOW_RATE 1 mL/min CH:COLUMN_TEMPERATURE programmed CH:METHODS_FILENAME Chrom_FAME.txt #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME LECO Pegasus BT MS:INSTRUMENT_TYPE TOF MS:MS_TYPE EI MS:ION_MODE POSITIVE MS:MS_COMMENTS Transfer line and EI ion source temperatures were both kept at 250 ºC. Electron MS:MS_COMMENTS energy was 70 eV. GCMS data were processed using ChromaTOF. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS µmol/dL plasma MS_METABOLITE_DATA_START Samples NC-001 NC-002 NC-003 NC-005 NC-008 NC-009 NC-010 NC-011 NC-012 NC-013 NC-020 NC-021 NC-022 NC-023 NC-024 NC-025 NC-026 NC-029 NC-031 NC-033 NC-034 NC-035 NC-036 NC-037 NC-038 NC-039 NC-040 NC-041 NC-042 NC-043 NC-044 NC-045 NC-046 NC-047 NC-048 NC-049 NC-050 NC-051 NC-052 NC-053 NC-054 NC-055 NC-056 NC-057 NC-058 NC-059 NC-060 NC-061 NC-062 NC-063 NC-064 NC-065 NC-066 NC-067 NC-068 NC-069 NC-070 NC-071 NC-072 NC-073 NC-074 NC-075 NC-076 NC-077 NC-078 NC-079 NC-080 NC-081 NC-084 NC-085 NC-086 NC-087 NC-089 NC-092 NC-093 NC-094 NC-095 NC-098 NC-099 NC-100 NC-101 NC-102 NC-103 NC-104 NC-106 NC-107 NC-108 NC-110 NC-111 NC-112 NC-113 NC-114 NC-115 NC-116 NC-126 Factors Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS Sample source:plasma | Factor:MetS-MCI Sample source:plasma | Factor:MetS-MCI C12:0 6.69 3.34 53.46 63.90 17.92 5.74 4.59 4.19 3.14 9.09 10.03 5.59 4.09 5.29 5.14 5.09 9.34 31.85 6.69 5.64 6.69 5.74 5.69 9.34 4.99 4.39 4.44 9.98 7.69 3.74 3.19 4.79 5.14 5.69 7.14 24.31 7.79 4.24 4.44 4.04 3.79 5.49 5.29 4.44 4.99 4.39 17.22 3.34 6.14 25.01 15.38 13.03 10.18 7.74 6.74 8.84 5.14 7.09 7.74 7.09 8.74 8.74 9.68 C16:0 319.48 241.99 282.35 467.71 271.00 537.71 173.93 103.42 308.63 598.47 202.40 281.22 301.42 190.86 190.08 136.30 228.18 174.01 314.25 203.38 349.35 272.99 196.98 185.94 199.98 210.51 218.31 467.79 243.39 594.53 397.59 215.43 335.19 231.46 545.28 211.49 321.35 216.40 148.97 295.02 406.05 197.61 358.71 349.70 628.97 183.22 165.08 695.15 242.69 211.18 311.72 430.62 220.73 705.44 299.51 233.37 201.93 264.88 304.73 323.69 213.75 300.68 233.45 218.00 277.16 243.47 161.30 267.14 361.83 300.05 323.18 147.41 179.59 251.15 765.74 268.11 202.36 350.95 208.92 525.90 88.80 527.14 270.10 452.81 203.30 515.99 344.98 208.17 305.71 317.41 359.53 387.41 458.66 611.89 142.11 C16:1 [Z-9] 34.51 43.04 52.55 73.46 45.01 127.75 11.56 54.05 76.02 24.96 31.64 46.15 25.86 28.22 20.48 30.23 29.48 50.04 20.44 63.87 38.36 30.27 30.31 31.68 24.92 106.17 133.56 133.37 36.00 32.27 35.30 68.94 16.67 46.70 32.15 30.11 72.09 38.28 46.97 82.47 57.86 37.50 17.49 110.53 30.27 36.48 95.04 72.87 53.34 120.00 74.25 27.59 25.04 27.87 36.75 21.03 65.68 30.50 29.20 24.80 59.20 31.60 30.58 39.82 45.08 41.86 33.49 110.96 35.06 43.47 56.25 104.63 6.41 128.10 35.26 88.44 78.61 41.39 89.82 37.54 94.06 56.88 45.16 60.85 67.14 152.71 C18:0 90.44 80.84 84.18 124.39 80.70 130.58 40.63 24.96 82.28 166.75 96.10 91.11 95.40 60.74 44.92 56.24 83.94 72.72 99.51 66.12 114.24 95.61 74.38 46.54 58.31 70.97 69.07 103.62 84.39 138.24 102.64 77.57 99.75 99.30 90.47 73.39 110.47 75.22 21.86 78.49 137.05 81.23 106.92 90.12 155.92 54.83 62.85 167.07 82.95 63.69 112.27 102.71 67.07 171.99 92.30 70.97 85.10 76.41 95.50 97.43 75.33 96.87 73.18 77.68 66.33 108.19 34.73 105.98 120.04 90.86 133.22 27.42 75.82 79.82 167.73 106.05 72.65 75.11 70.62 149.53 17.47 130.02 112.23 145.94 62.39 156.41 95.75 76.56 82.21 67.84 85.27 97.15 136.13 145.41 26.15 C18:1 [Z-9] 272.54 264.08 241.89 317.86 302.60 552.06 49.77 52.75 199.05 454.93 196.86 264.72 322.35 123.44 132.93 122.52 230.81 144.47 258.31 141.00 355.27 245.75 158.52 54.62 169.53 191.73 191.16 350.88 193.11 435.35 385.97 230.35 267.48 186.17 401.47 223.23 294.10 228.90 40.25 184.89 285.39 149.56 341.36 333.89 520.80 158.98 135.37 796.22 214.03 186.10 303.59 308.94 187.94 706.73 220.79 213.85 179.76 190.06 344.19 193.50 206.17 262.24 218.28 173.53 209.67 238.17 50.55 193.21 278.88 291.55 331.38 50.73 123.12 241.50 549.44 202.91 168.26 220.75 183.69 458.36 38.41 445.01 110.34 483.85 164.93 623.11 342.92 166.80 264.58 414.18 284.90 246.60 480.70 528.10 52.39 C18:2[Z,Z-9,12] 329.57 268.28 264.54 270.89 153.27 329.86 83.28 68.38 304.12 480.34 418.06 329.07 322.69 182.50 105.07 139.29 254.67 141.83 351.60 246.50 274.31 315.49 246.00 83.43 165.21 262.29 228.32 321.44 354.81 420.70 219.55 312.85 394.64 287.29 316.09 302.51 323.97 222.65 62.50 255.06 568.94 216.87 293.35 247.32 498.24 197.76 194.23 648.27 332.07 211.53 297.63 461.84 208.60 221.33 186.85 335.95 282.22 451.04 361.16 354.81 277.09 563.88 213.45 285.18 158.23 335.88 79.86 466.23 336.13 359.48 385.51 78.44 203.54 347.04 607.23 333.31 165.11 307.11 239.94 430.82 54.41 459.81 186.25 376.81 102.43 564.38 324.19 272.63 244.90 223.43 348.97 449.90 517.46 284.15 81.72 C14:0 16.95 15.19 14.49 64.45 14.01 56.62 11.78 7.40 15.50 61.91 13.75 16.81 9.28 13.44 7.18 17.69 9.90 24.61 10.60 24.35 12.17 12.52 12.48 11.87 14.54 13.36 27.02 11.73 43.26 44.79 18.04 18.57 18.92 27.15 13.00 24.74 13.22 11.21 17.60 24.43 10.60 29.69 26.89 34.94 11.78 6.61 21.02 11.69 15.98 22.46 23.60 9.63 49.30 59.38 16.20 10.64 13.57 15.81 12.09 12.30 14.98 17.78 11.69 16.29 16.20 12.39 12.57 35.38 11.34 16.86 11.95 8.10 18.52 60.08 30.08 17.47 40.37 21.98 33.72 45.23 20.05 42.30 15.46 25.88 23.21 13.18 27.15 12.83 18.48 28.42 36.12 45.49 C20:3 [all-Z-8,11,14] 14.32 18.89 21.27 26.33 19.83 34.02 23.72 22.61 28.71 23.81 24.96 20.42 13.57 13.41 16.08 18.76 26.26 17.75 29.91 16.90 20.72 19.80 47.37 21.79 19.80 22.12 14.52 23.75 19.02 14.65 24.63 33.50 16.57 23.49 35.75 16.25 35.23 20.03 23.23 22.38 19.44 29.10 26.62 22.71 20.58 23.42 20.68 16.02 16.64 17.91 20.91 22.25 18.27 21.92 18.40 18.59 20.62 23.39 29.91 17.65 26.68 31.97 16.08 26.59 31.81 30.80 31.81 16.70 20.85 32.88 23.19 33.11 12.23 29.91 23.23 30.05 34.51 20.85 C20:4 [all-Z-5,8,11,14] 74.97 73.88 67.02 80.32 52.80 72.11 12.02 108.10 84.32 68.92 86.03 101.53 31.19 18.29 83.08 79.14 56.97 83.80 82.45 100.18 136.11 53.69 41.47 64.82 44.16 102.09 96.24 114.24 59.86 80.81 105.37 107.44 78.28 59.27 64.43 88.63 79.69 119.95 65.51 79.63 110.20 160.57 52.74 93.98 108.52 109.44 70.34 123.33 91.78 56.68 100.68 92.47 53.52 82.52 91.91 75.62 60.91 83.73 92.73 71.42 48.63 81.40 99.46 89.77 66.46 110.63 135.61 75.72 76.11 68.27 102.25 82.88 54.38 75.59 101.60 150.23 109.77 105.70 64.95 61.47 123.50 104.55 85.31 57.60 100.51 87.08 103.89 90.60 C22:6 [ all-Z-4,7,10,13,16,19] 52.16 34.88 34.57 21.67 37.01 35.45 31.95 25.02 27.57 23.07 26.29 30.19 33.99 27.45 48.91 51.07 31.95 23.92 33.26 40.93 45.59 33.23 55.36 41.42 40.78 63.30 57.12 43.24 34.24 45.01 48.36 49.03 33.93 69.54 66.92 41.69 24.83 39.90 38.22 34.48 53.84 31.32 50.85 33.48 40.72 30.49 26.20 48.87 49.00 38.53 35.55 46.44 43.52 32.08 54.90 49.91 43.91 71.61 16.10 33.23 33.63 53.17 41.72 41.02 58.28 34.91 40.35 63.42 50.21 38.62 34.48 59.10 43.43 49.24 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name PubChem ID C12:0 8139 C16:0 8181 C16:1 [Z-9] 643801 C18:0 8201 C18:1 [Z-9] 5364509 C18:2[Z,Z-9,12] 5284421 C14:0 31284 C20:3 [all-Z-8,11,14] 5363092 C20:4 [all-Z-5,8,11,14] 6421258 C22:6 [ all-Z-4,7,10,13,16,19] 6421262 METABOLITES_END #END