#METABOLOMICS WORKBENCH louisen_20250606_060120 DATATRACK_ID:6003 STUDY_ID:ST003983 ANALYSIS_ID:AN006559 PROJECT_ID:PR002492
VERSION             	1
CREATED_ON             	June 16, 2025, 6:47 pm
#PROJECT
PR:PROJECT_TITLE                 	Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and
PR:PROJECT_TITLE                 	lethality in sepsis
PR:PROJECT_SUMMARY               	Sepsis, killing 11 million people yearly, is associated with increased lactate
PR:PROJECT_SUMMARY               	production - a metabolite mechanistically linked to mortality - complicating
PR:PROJECT_SUMMARY               	glucose administration in sepsis. To understand the mechanism behind
PR:PROJECT_SUMMARY               	hyperlactatemia, we applied the cecal ligation and puncture (CLP) model and
PR:PROJECT_SUMMARY               	studied all pyruvate processing routes in liver mitochondria during acute
PR:PROJECT_SUMMARY               	sepsis. Our data suggest that mitochondrial pyruvate-driven respiration is
PR:PROJECT_SUMMARY               	nearly nonexistent in sepsis, not due to insufficient pyruvate uptake or
PR:PROJECT_SUMMARY               	carboxylation but due to a dysfunctional pyruvate dehydrogenase complex (PDC).
PR:PROJECT_SUMMARY               	Septic mitochondria compensate by glutamate-mediated TCA anaplerosis,
PR:PROJECT_SUMMARY               	simultaneously converting some pyruvate into alanine via enhanced mitochondrial
PR:PROJECT_SUMMARY               	glutamic pyruvate transaminase (GPT2) activity. Notably, PDC dysfunction is not
PR:PROJECT_SUMMARY               	caused by PDC inactivation per se but by a shortage of its cofactor, thiamine
PR:PROJECT_SUMMARY               	pyrophosphate (TPP). TPP supplementation restores pyruvate oxidation both ex
PR:PROJECT_SUMMARY               	vivo and in vivo and protects mice from sepsis. TPP also allows safe glucose
PR:PROJECT_SUMMARY               	administration in mice, leading to a novel, robust TPP-plus-glucose therapy.
PR:INSTITUTE                     	Ghent University
PR:DEPARTMENT                    	Inflammation research center - VIB
PR:LABORATORY                    	Mouse Genetics in Inflammation
PR:LAST_NAME                     	Libert
PR:FIRST_NAME                    	Claude
PR:ADDRESS                       	Technologiepark-Zwijnaarde 71, 9052 Ghent, Belgium
PR:EMAIL                         	claude.libert@irc.vib-ugent.be
PR:PHONE                         	09/331.37.00
#STUDY
ST:STUDY_TITLE                   	Mitochondrial pyruvate metabolism is disturbed and contributes to
ST:STUDY_TITLE                   	hyperlactatemia and lethality in sepsis - Lung, Heart, Spleen, Kidney, RBC
ST:STUDY_SUMMARY                 	To determine the source of lactate production in sepsis, lactate dehydrogenase A
ST:STUDY_SUMMARY                 	(LDHA) activity was examined in several organs of sham and cecal ligation and
ST:STUDY_SUMMARY                 	puncture (CLP) mice using 13C3 pyruvate tracer metabolomics assay. Septic heart
ST:STUDY_SUMMARY                 	and skeletal muscle did not show an enhanced 13C labeling of lactate, indicating
ST:STUDY_SUMMARY                 	that LDHA activity is not increased in these tissues and that they are unlikely
ST:STUDY_SUMMARY                 	to be major sources of elevated lactate production in sepsis. Conversely, septic
ST:STUDY_SUMMARY                 	liver, kidney, spleen and lung were characterized by a notably higher
ST:STUDY_SUMMARY                 	13C-labeling for lactate, indicating elevated local lactate production that may
ST:STUDY_SUMMARY                 	contribute to systemic hyperlactatemia.
ST:INSTITUTE                     	Ghent University
ST:LAST_NAME                     	Libert
ST:FIRST_NAME                    	Claude
ST:ADDRESS                       	Technologiepark-Zwijnaarde 71, 9052 Ghent, Belgium
ST:EMAIL                         	claude.libert@irc.vib-ugent.be
ST:PHONE                         	09/331.37.00
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN01	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN01.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN02	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN02.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN03	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN03.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN04	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN04.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN05	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN05.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN06	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN06.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN07	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN07.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN08	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN08.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN09	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN09.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN10	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN10.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN11	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN11.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN12	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN12.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN13	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN13.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN14	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN14.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN15	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN15.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN16	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN16.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN17	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN17.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN18	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN18.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN19	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN19.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN20	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN20.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN21	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN21.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN22	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN22.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN23	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN23.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN24	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN24.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN25	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN25.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN26	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN26.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN27	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN27.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN28	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN28.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN29	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN29.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN30	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN30.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN31	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN31.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN32	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN32.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN33	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN33.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN34	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN34.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN35	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN35.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN36	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN36.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN37	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN37.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN38	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN38.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN39	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN39.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN40	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN40.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN41	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN41.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN42	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN42.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN43	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN43.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN44	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN44.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN45	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN45.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN46	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN46.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN47	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN47.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN48	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN48.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN49	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN49.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN50	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	RAW_FILE_NAME(Raw file name)=MCF001221_LN50.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN51	Sample source:Lung | Treatment condition:CLP | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN51.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN52	Sample source:Heart | Treatment condition:CLP | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN52.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN53	Sample source:Spleen | Treatment condition:CLP | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN53.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN54	Sample source:Kidney | Treatment condition:CLP | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN54.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN55	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN55.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN56	Sample source:Lung | Treatment condition:Sham | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN56.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN57	Sample source:Heart | Treatment condition:Sham | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN57.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN58	Sample source:Spleen | Treatment condition:Sham | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN58.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN59	Sample source:Kidney | Treatment condition:Sham | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN59.raw
SUBJECT_SAMPLE_FACTORS           	-	MCF001221_LN60	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:PBS	RAW_FILE_NAME(Raw file name)=MCF001221_LN90.raw
#COLLECTION
CO:COLLECTION_SUMMARY            	Mice were subjected to the cecal ligation and puncture (CLP) (n=5) to induce
CO:COLLECTION_SUMMARY            	polymicrobial sepsis and the sham (control) procedure (n=5). After 24h, mice
CO:COLLECTION_SUMMARY            	were injected with 13C3, 99% sodium pyruvate (2 g/kg; Buchem B.V. CLM-2440-0.5)
CO:COLLECTION_SUMMARY            	or PBS and 90 minutes after injection organs of interest (lungs, kidney, spleen,
CO:COLLECTION_SUMMARY            	heart and red blood cells) were isolated and snapfrozen in liquid nitrogen and
CO:COLLECTION_SUMMARY            	stored at -80°C for further analysis.
CO:SAMPLE_TYPE                   	Lung, Heart, Spleen, Kidney, RBC
CO:ADDITIVES                     	Additional sample source/type: spleen, kidney, heart and red blood cells
#TREATMENT
TR:TREATMENT_SUMMARY             	Mice were subjected to the cecal ligation and puncture (CLP) (n=5), as described
TR:TREATMENT_SUMMARY             	by Rittirsch et al. (Nature Protocols: 2009;4(1):31-6. doi:
TR:TREATMENT_SUMMARY             	10.1038/nprot.2008.214), to induce polymicrobial sepsis and the sham (control,
TR:TREATMENT_SUMMARY             	n=5) procedure. After 24h, mice were injected with 13C3, 99% sodium pyruvate (2
TR:TREATMENT_SUMMARY             	g/kg; Buchem B.V. CLM-2440-0.5) or PBS and 90 minutes after injection organs of
TR:TREATMENT_SUMMARY             	interest (lungs, kidney, spleen, heart and red blood cells) were isolated and
TR:TREATMENT_SUMMARY             	snapfrozen in liquid nitrogen and stored at -80°C for further analysis.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Lungs, spleen, kidney, heart and red blood cells were isolated 90 minutes after
SP:SAMPLEPREP_SUMMARY            	13C pyruvate or PBS injection, snapfrozen in liquid nitrogen and stored at
SP:SAMPLEPREP_SUMMARY            	-80°C until further analysis by the VIB metabolomics core (KU Leuven, Belgium).
SP:SAMPLEPREP_PROTOCOL_FILENAME  	Protocol_methods_invivo_13Cpyruvate.pdf
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	Thermo Dionex Ultimate 3000
CH:COLUMN_NAME                   	Agilent InfinityLab Poroshell 120 HILIC-Z (150 x 2.1mm, 2.7um)
CH:SOLVENT_A                     	100% acetonitrile
CH:SOLVENT_B                     	100% water; 10 mM sodium acetate (pH 9.3)
CH:FLOW_GRADIENT                 	A linear gradient was carried out starting with 90% solvent A and 10% solvent B.
CH:FLOW_GRADIENT                 	From 2 to 12 min the gradient changed to 60% B. The gradient was kept on 60% B
CH:FLOW_GRADIENT                 	for 3 min and followed by a decrease to 10% B. The chromatography was stopped at
CH:FLOW_GRADIENT                 	25 min
CH:FLOW_RATE                     	0.25 mL/min
CH:COLUMN_TEMPERATURE            	25°C
CH:METHODS_FILENAME              	Protocol_methods_invivo_13Cpyruvate.pdf
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
AN:ANALYSIS_PROTOCOL_FILE        	Protocol_methods_invivo_13Cpyruvate.pdf
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	- Mass spectrometry was performed in full scan mode (range 70–1050 m/z) using
MS:MS_COMMENTS                   	negative electrospray ionization. The spray voltage was 2.8 kV; capillary
MS:MS_COMMENTS                   	temperature 320°C; sheath gas 45; auxiliary gas 10; AGC target 3.0E+06;
MS:MS_COMMENTS                   	resolution 70,000. Data were acquired using Xcalibur software (Thermo
MS:MS_COMMENTS                   	Scientific). - Raw intensities were extracted for each metabolite and corrected
MS:MS_COMMENTS                   	for natural ¹³C abundance to calculate fractional contribution and
MS:MS_COMMENTS                   	isotopologue enrichment. Detection limits were estimated using blanks. Data
MS:MS_COMMENTS                   	processing included isotopologue deconvolution and signal normalization. -
MS:MS_COMMENTS                   	Xcalibur (Thermo Scientific) for data acquisition
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	peak intensity
MS_METABOLITE_DATA_START
Samples	MCF001221_LN02	MCF001221_LN07	MCF001221_LN12	MCF001221_LN17	MCF001221_LN22	MCF001221_LN27	MCF001221_LN32	MCF001221_LN37	MCF001221_LN42	MCF001221_LN47	MCF001221_LN52	MCF001221_LN57	MCF001221_LN04	MCF001221_LN09	MCF001221_LN14	MCF001221_LN19	MCF001221_LN24	MCF001221_LN29	MCF001221_LN34	MCF001221_LN39	MCF001221_LN44	MCF001221_LN49	MCF001221_LN54	MCF001221_LN59	MCF001221_LN01	MCF001221_LN06	MCF001221_LN11	MCF001221_LN16	MCF001221_LN21	MCF001221_LN26	MCF001221_LN31	MCF001221_LN36	MCF001221_LN41	MCF001221_LN46	MCF001221_LN51	MCF001221_LN56	MCF001221_LN03	MCF001221_LN08	MCF001221_LN13	MCF001221_LN18	MCF001221_LN23	MCF001221_LN28	MCF001221_LN33	MCF001221_LN38	MCF001221_LN43	MCF001221_LN48	MCF001221_LN53	MCF001221_LN58	MCF001221_LN05	MCF001221_LN10	MCF001221_LN15	MCF001221_LN20	MCF001221_LN25	MCF001221_LN30	MCF001221_LN35	MCF001221_LN40	MCF001221_LN45	MCF001221_LN50	MCF001221_LN55	MCF001221_LN60
Factors	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Heart | Treatment condition:CLP | Tracer condition:PBS	Sample source:Heart | Treatment condition:Sham | Tracer condition:PBS	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Kidney | Treatment condition:CLP | Tracer condition:PBS	Sample source:Kidney | Treatment condition:Sham | Tracer condition:PBS	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Lung | Treatment condition:CLP | Tracer condition:PBS	Sample source:Lung | Treatment condition:Sham | Tracer condition:PBS	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Spleen | Treatment condition:CLP | Tracer condition:PBS	Sample source:Spleen | Treatment condition:Sham | Tracer condition:PBS	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:13C pyruvate	Sample source:Red blood cells | Treatment condition:CLP | Tracer condition:PBS	Sample source:Red blood cells | Treatment condition:Sham | Tracer condition:PBS
L-Lactic acid_PARENT	245E+11	314E+11	256E+11	352E+11	249E+11	241E+11	334E+11	281E+11	367E+11	327E+11	316E+11	288E+11	185E+11	158E+11	217E+11	232E+11	189E+11	215E+11	162E+11	164E+11	213E+11	231E+11	218E+11	234E+11	556E+10	568E+10	782E+10	948E+10	556E+10	574E+10	609E+10	543E+10	604E+10	925E+10	630E+10	843E+10	106E+11	763E+10	124E+11	118E+11	990E+10	102E+11	838E+10	871E+10	111E+11	123E+11	112E+11	118E+11	252E+10	308E+10	399E+10	383E+10	334E+10	287E+10	229E+10	244E+10	299E+10	276E+10	194E+10	322E+10
L-Lactic acid_C13-label-1	159E+10	215E+10	145E+10	243E+10	160E+10	156E+10	207E+10	169E+10	231E+10	242E+10	111E+10	106E+10	147E+10	298E+10	162E+10	345E+10	165E+10	183E+10	270E+10	161E+10	306E+10	299E+10	768E+09	875E+09	420E+09	944E+09	600E+09	132E+10	495E+09	514E+09	885E+09	523E+09	774E+09	123E+10	227E+09	317E+09	793E+09	145E+10	926E+09	169E+10	891E+09	867E+09	142E+10	868E+09	168E+10	173E+10	399E+09	443E+09	211E+09	556E+09	326E+09	600E+09	342E+09	292E+09	440E+09	277E+09	454E+09	376E+09	732E+08	129E+09
L-Lactic acid_C13-label-2	554E+09	805E+09	467E+09	876E+09	632E+09	591E+09	687E+09	715E+09	702E+09	109E+10	953E+07	420E+08	912E+09	174E+10	607E+09	185E+10	711E+09	744E+09	140E+10	763E+09	144E+10	169E+10	592E+07	284E+08	170E+09	569E+09	277E+09	706E+09	244E+09	256E+09	472E+09	294E+09	368E+09	738E+09	543E+07	157E+08	304E+09	898E+09	391E+09	942E+09	418E+09	386E+09	808E+09	461E+09	888E+09	108E+10	574E+07	173E+08	955E+08	360E+09	151E+09	354E+09	184E+09	154E+09	271E+09	166E+09	245E+09	235E+09	343E+06	694E+07
L-Lactic acid_C13-label-3	742E+09	103E+10	752E+09	129E+10	866E+09	808E+09	895E+09	107E+10	701E+09	175E+10	107E+06	209E+08	709E+10	189E+10	102E+10	220E+10	862E+09	796E+09	137E+10	925E+09	113E+10	227E+10	431E+06	107E+08	291E+09	767E+09	530E+09	103E+10	389E+09	454E+09	602E+09	520E+09	419E+09	124E+10	612E+07	121E+08	474E+09	106E+10	691E+09	131E+10	602E+09	567E+09	970E+09	707E+09	942E+09	169E+10	417E+07	853E+07	155E+09	459E+09	242E+09	561E+09	238E+09	209E+09	267E+09	226E+09	396E+09	341E+09	220E+03	324E+07
D-Glyceraldehyde 3-phosphate_PARENT	754E+06	439E+07	379E+07	551E+07	192E+07	120E+07	646E+07	504E+07	465E+07	108E+08	881E+07	628E+07	431E+06	701E+06	733E+06	773E+06	756E+06	871E+06	691E+06	715E+06	858E+06	108E+07	118E+07	112E+07	512E+07	597E+07	633E+07	931E+07	765E+07	667E+07	972E+07	101E+08	711E+07	109E+08	144E+08	149E+08	642E+07	628E+07	716E+07	679E+07	959E+07	913E+07	884E+07	100E+08	886E+07	111E+08	114E+08	122E+08	884E+06	117E+07	924E+06	203E+07	335E+06	347E+06	135E+07	337E+06	143E+07	102E+07	480E+06	625E+06
D-Glyceraldehyde 3-phosphate_C13-label-1	692E+04	119E+06	985E+05	141E+06	504E+05	105E+05	167E+06	939E+05	890E+05	282E+06	231E+06	154E+06	000E+00	000E+00	000E+00	137E+05	000E+00	000E+00	141E+05	000E+00	357E+04	392E+04	107E+05	000E+00	151E+06	332E+06	218E+06	398E+06	287E+06	245E+06	464E+06	386E+06	301E+06	435E+06	425E+06	406E+06	223E+06	311E+06	235E+06	236E+06	333E+06	292E+06	455E+06	384E+06	332E+06	451E+06	311E+06	327E+06	445E+05	173E+06	303E+05	251E+06	994E+04	131E+05	236E+06	159E+05	228E+06	114E+06	351E+04	677E+04
D-Glyceraldehyde 3-phosphate_C13-label-2	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	707E+05	000E+00	263E+05	000E+00	000E+00	302E+05	655E+04	715E+04	230E+05	000E+00	000E+00	000E+00	350E+05	000E+00	000E+00	000E+00	000E+00	166E+05	823E+04	225E+04	150E+05	000E+00	000E+00	447E+04	902E+05	125E+04	971E+05	216E+04	000E+00	112E+06	334E+04	956E+05	576E+05	000E+00	000E+00
D-Glyceraldehyde 3-phosphate_C13-label-3	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	165E+06	320E+06	148E+06	316E+06	236E+06	366E+06	268E+06	301E+06	314E+06	307E+06	393E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	604E+04	703E+05	789E+04	879E+05	244E+04	000E+00	770E+05	000E+00	516E+05	372E+05	109E+04	163E+04
Pyruvic acid_PARENT	103E+09	182E+09	816E+08	143E+09	603E+08	959E+08	100E+09	103E+09	858E+08	111E+09	967E+08	168E+09	122E+10	439E+08	483E+08	535E+08	524E+08	489E+08	365E+08	295E+08	221E+08	346E+08	420E+08	260E+08	312E+09	433E+09	417E+09	442E+09	381E+09	398E+09	577E+09	327E+09	407E+09	818E+09	476E+09	561E+09	343E+09	560E+09	379E+09	444E+09	485E+09	378E+09	692E+09	444E+09	539E+09	156E+10	458E+09	423E+09	154E+09	846E+08	859E+09	505E+08	760E+09	104E+10	550E+09	951E+09	345E+08	431E+09	906E+09	701E+09
Pyruvic acid_C13-label-1	537E+07	890E+07	357E+07	664E+07	308E+07	500E+07	423E+07	433E+07	358E+07	466E+07	315E+07	548E+07	762E+08	246E+07	192E+07	307E+07	213E+07	205E+07	179E+07	982E+06	541E+06	159E+07	899E+06	504E+06	167E+08	487E+08	237E+08	386E+08	222E+08	239E+08	549E+08	204E+08	351E+08	637E+08	152E+08	189E+08	186E+08	652E+08	203E+08	331E+08	309E+08	212E+08	769E+08	299E+08	451E+08	137E+09	144E+08	143E+08	109E+08	110E+08	646E+08	469E+07	717E+08	968E+08	956E+08	100E+09	279E+07	523E+08	308E+08	257E+08
Pyruvic acid_C13-label-2	761E+06	231E+07	142E+06	127E+07	226E+06	785E+06	217E+06	195E+06	647E+05	339E+06	000E+00	000E+00	896E+08	260E+06	632E+04	535E+06	000E+00	309E+05	564E+05	245E+05	142E+05	186E+06	000E+00	000E+00	415E+07	259E+08	670E+07	165E+08	615E+07	758E+07	247E+08	688E+07	128E+08	280E+08	168E+05	370E+06	517E+07	403E+08	604E+07	156E+08	117E+08	668E+07	434E+08	127E+08	196E+08	748E+08	000E+00	207E+06	426E+07	625E+07	287E+08	225E+07	375E+08	510E+08	587E+08	588E+08	955E+06	322E+08	174E+06	149E+07
Pyruvic acid_C13-label-3	974E+06	476E+07	460E+06	619E+07	546E+06	100E+07	102E+07	456E+06	170E+06	505E+07	000E+00	000E+00	145E+10	674E+07	365E+06	126E+08	295E+06	142E+06	117E+07	216E+05	266E+07	886E+07	000E+00	000E+00	558E+07	338E+08	102E+08	310E+08	758E+07	947E+07	268E+08	876E+07	124E+08	604E+08	000E+00	853E+05	914E+07	591E+08	122E+08	448E+08	164E+08	112E+08	532E+08	170E+08	170E+08	160E+09	000E+00	411E+05	724E+07	100E+08	434E+08	683E+07	466E+08	682E+08	569E+08	772E+08	255E+07	472E+08	000E+00	751E+06
Citric acid_PARENT	103E+10	944E+09	115E+10	101E+10	145E+10	106E+10	107E+10	113E+10	926E+09	169E+10	799E+09	140E+10	592E+10	303E+10	284E+10	322E+10	277E+10	269E+10	278E+10	308E+10	215E+10	386E+10	189E+10	198E+10	610E+09	779E+09	873E+09	924E+09	849E+09	886E+09	733E+09	853E+09	496E+09	992E+09	603E+09	598E+09	105E+10	139E+10	168E+10	147E+10	161E+10	120E+10	193E+10	135E+10	125E+10	290E+10	189E+10	138E+10	315E+09	288E+09	218E+09	233E+09	177E+09	147E+09	137E+09	142E+09	142E+09	115E+09	996E+08	111E+09
Citric acid_C13-label-1	156E+09	200E+09	221E+09	280E+09	237E+09	181E+09	204E+09	169E+09	231E+09	441E+09	117E+09	147E+09	114E+10	963E+09	570E+09	101E+10	527E+09	529E+09	784E+09	606E+09	721E+09	129E+10	334E+09	286E+09	970E+08	209E+09	163E+09	270E+09	157E+09	162E+09	173E+09	155E+09	122E+09	289E+09	100E+09	863E+08	154E+09	327E+09	293E+09	348E+09	286E+09	215E+09	434E+09	237E+09	319E+09	776E+09	222E+09	159E+09	445E+08	487E+08	338E+08	436E+08	279E+08	230E+08	219E+08	217E+08	238E+08	201E+08	147E+08	148E+08
Citric acid_C13-label-2	477E+08	656E+08	791E+08	123E+09	788E+08	666E+08	651E+08	532E+08	934E+08	189E+09	316E+08	233E+08	679E+09	489E+09	278E+09	579E+09	219E+09	231E+09	366E+09	248E+09	475E+09	728E+09	139E+09	969E+08	330E+08	102E+09	672E+08	155E+09	642E+08	643E+08	776E+08	612E+08	685E+08	179E+09	422E+08	301E+08	469E+08	157E+09	121E+09	175E+09	999E+08	748E+08	196E+09	738E+08	219E+09	455E+09	633E+08	397E+08	149E+08	194E+08	126E+08	214E+08	111E+08	893E+07	900E+07	799E+07	110E+08	947E+07	576E+07	524E+07
Citric acid_C13-label-3	618E+07	126E+08	127E+08	310E+08	153E+08	970E+07	107E+08	716E+07	185E+08	464E+08	740E+07	523E+07	286E+09	178E+09	816E+08	221E+09	713E+08	673E+08	105E+09	734E+08	168E+09	279E+09	501E+08	331E+08	101E+08	321E+08	179E+08	514E+08	181E+08	171E+08	210E+08	157E+08	204E+08	665E+08	146E+08	104E+08	133E+08	453E+08	358E+08	563E+08	311E+08	205E+08	486E+08	186E+08	692E+08	146E+09	203E+08	125E+08	470E+07	678E+07	412E+07	739E+07	373E+07	288E+07	287E+07	258E+07	362E+07	372E+07	205E+07	185E+07
Citric acid_C13-label-4	174E+07	300E+07	320E+07	839E+07	476E+07	276E+07	284E+07	192E+07	393E+07	124E+08	221E+07	177E+07	141E+09	541E+08	280E+08	733E+08	226E+08	212E+08	264E+08	222E+08	540E+08	880E+08	162E+08	112E+08	374E+07	965E+07	579E+07	163E+08	584E+07	532E+07	606E+07	469E+07	662E+07	234E+08	554E+07	403E+07	528E+07	128E+08	145E+08	176E+08	110E+08	690E+07	130E+08	630E+07	243E+08	461E+08	704E+07	450E+07	177E+07	271E+07	158E+07	297E+07	147E+07	106E+07	957E+06	102E+07	153E+07	153E+07	834E+06	641E+06
Citric acid_C13-label-5	162E+06	338E+06	653E+06	221E+07	146E+07	381E+06	479E+06	109E+06	428E+06	341E+07	290E+06	134E+06	675E+08	171E+08	116E+08	232E+08	850E+07	793E+07	718E+07	845E+07	146E+08	266E+08	537E+07	381E+07	113E+07	238E+07	163E+07	431E+07	162E+07	148E+07	133E+07	124E+07	153E+07	641E+07	144E+07	102E+07	179E+07	296E+07	564E+07	497E+07	367E+07	207E+07	283E+07	181E+07	611E+07	122E+08	198E+07	126E+07	244E+06	536E+06	182E+06	667E+06	149E+06	888E+05	702E+05	277E+05	165E+06	295E+06	258E+05	219E+05
Citric acid_C13-label-6	125E+05	727E+04	275E+05	248E+06	143E+06	172E+05	117E+05	000E+00	860E+04	554E+06	148E+05	467E+04	251E+08	517E+07	395E+07	606E+07	270E+07	242E+07	182E+07	272E+07	275E+07	675E+07	150E+07	101E+07	657E+05	267E+06	924E+05	947E+06	164E+06	735E+05	519E+05	622E+05	283E+05	176E+07	102E+06	398E+05	391E+06	371E+06	208E+07	130E+07	118E+07	527E+06	430E+06	343E+06	103E+07	324E+07	150E+06	331E+05	111E+04	718E+04	206E+04	270E+05	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	131E+04	130E+04
Fumaric acid_PARENT	958E+08	109E+09	620E+08	805E+08	565E+08	921E+08	820E+08	114E+09	104E+09	102E+09	119E+09	682E+08	406E+08	596E+08	509E+08	627E+08	573E+08	512E+08	402E+08	379E+08	457E+08	863E+08	718E+08	208E+08	343E+08	415E+08	378E+08	610E+08	505E+08	409E+08	613E+08	546E+08	453E+08	787E+08	772E+08	570E+08	544E+08	465E+08	786E+08	621E+08	756E+08	652E+08	779E+08	661E+08	563E+08	914E+08	955E+08	772E+08	145E+07	203E+07	929E+06	230E+07	822E+06	626E+06	593E+06	679E+06	148E+07	617E+06	457E+06	559E+06
Fumaric acid_C13-label-1	118E+08	161E+08	102E+08	178E+08	532E+07	110E+08	991E+07	105E+08	239E+08	175E+08	520E+07	297E+07	538E+07	149E+08	714E+07	141E+08	651E+07	648E+07	831E+07	463E+07	127E+08	184E+08	308E+07	931E+06	363E+07	102E+08	462E+07	155E+08	555E+07	483E+07	121E+08	642E+07	112E+08	186E+08	390E+07	278E+07	713E+07	108E+08	120E+08	140E+08	927E+07	974E+07	165E+08	889E+07	136E+08	201E+08	447E+07	391E+07	121E+06	171E+06	874E+05	356E+06	841E+05	567E+05	674E+05	615E+05	221E+06	698E+05	145E+05	201E+05
Fumaric acid_C13-label-2	273E+07	381E+07	276E+07	529E+07	536E+05	269E+07	124E+07	168E+07	815E+07	465E+07	000E+00	000E+00	117E+07	492E+07	177E+07	406E+07	138E+07	161E+07	145E+07	238E+06	483E+07	654E+07	000E+00	000E+00	572E+06	396E+07	818E+06	683E+07	101E+07	908E+06	442E+07	169E+07	540E+07	944E+07	172E+06	387E+05	131E+07	465E+07	318E+07	584E+07	163E+07	223E+07	620E+07	161E+07	928E+07	861E+07	332E+06	203E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
Fumaric acid_C13-label-3	201E+06	508E+06	271E+06	783E+06	405E+04	193E+06	214E+06	177E+06	124E+07	713E+06	000E+00	000E+00	141E+07	108E+07	403E+06	907E+06	464E+06	337E+06	496E+06	325E+06	130E+07	145E+07	453E+04	000E+00	114E+06	850E+06	173E+06	144E+07	224E+06	201E+06	866E+06	330E+06	119E+07	214E+07	787E+05	847E+04	177E+06	107E+07	527E+06	120E+07	273E+06	357E+06	128E+07	300E+06	247E+07	198E+07	542E+05	481E+04	796E+03	000E+00	153E+04	262E+05	899E+03	000E+00	152E+04	115E+04	113E+05	897E+03	000E+00	000E+00
Fumaric acid_C13-label-4	000E+00	489E+05	286E+04	482E+05	000E+00	000E+00	533E+04	729E+04	869E+05	110E+06	000E+00	000E+00	688E+06	141E+06	395E+05	106E+06	313E+05	309E+05	120E+05	852E+04	225E+06	252E+06	000E+00	000E+00	163E+05	180E+06	288E+05	294E+06	315E+05	491E+05	189E+06	580E+05	223E+06	624E+06	452E+04	224E+04	445E+05	213E+06	140E+06	211E+06	583E+05	775E+05	264E+06	735E+05	353E+06	356E+06	000E+00	292E+04	300E+04	189E+04	000E+00	100E+05	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Malic acid_PARENT	807E+08	905E+08	809E+08	102E+09	126E+09	925E+08	134E+09	163E+09	146E+09	250E+09	265E+09	126E+09	108E+09	216E+09	122E+09	294E+09	140E+09	814E+08	118E+09	131E+09	178E+09	317E+09	908E+08	253E+07	495E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	222E+07	000E+00	000E+00	000E+00	000E+00	000E+00	111E+07	135E+07	000E+00	221E+07	000E+00	118E+07	969E+07	488E+07	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Malic acid_C13-label-1	102E+08	139E+08	137E+08	234E+08	127E+08	118E+08	170E+08	159E+08	346E+08	441E+08	125E+08	620E+07	163E+08	553E+08	180E+08	681E+08	172E+08	109E+08	256E+08	177E+08	497E+08	689E+08	424E+07	171E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	214E+07	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Malic acid_C13-label-2	295E+07	377E+07	447E+07	792E+07	294E+07	348E+07	385E+07	373E+07	128E+08	134E+08	306E+06	225E+06	766E+07	206E+08	571E+07	233E+08	493E+07	311E+07	865E+07	568E+07	223E+08	270E+08	182E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	922E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Malic acid_C13-label-3	236E+06	546E+06	439E+06	123E+07	241E+06	283E+06	443E+06	361E+06	203E+07	216E+07	416E+04	000E+00	590E+07	509E+07	121E+07	574E+07	138E+07	757E+06	210E+07	144E+07	676E+07	679E+07	163E+05	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	197E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Malic acid_C13-label-4	566E+04	675E+05	316E+05	125E+06	812E+04	141E+05	839E+05	397E+05	132E+06	411E+06	000E+00	000E+00	286E+07	842E+06	235E+06	987E+06	160E+06	121E+06	351E+06	262E+06	112E+07	140E+07	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	313E+05	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
Oxoglutaric acid_PARENT	233E+06	378E+06	115E+06	166E+06	110E+06	377E+06	127E+06	493E+06	138E+06	289E+06	112E+06	241E+06	680E+08	465E+06	181E+06	124E+06	118E+06	116E+06	884E+05	134E+06	109E+06	175E+06	787E+05	233E+06	484E+07	168E+08	111E+08	161E+08	136E+08	616E+07	275E+08	172E+08	217E+08	356E+08	183E+08	128E+08	360E+07	643E+07	386E+07	723E+07	887E+07	514E+07	769E+07	631E+07	698E+07	142E+08	110E+08	718E+07	778E+07	520E+07	890E+07	743E+07	108E+08	172E+08	168E+08	173E+08	419E+07	212E+08	138E+08	456E+07
Oxoglutaric acid_C13-label-1	181E+05	107E+05	000E+00	118E+05	000E+00	000E+00	000E+00	000E+00	000E+00	230E+05	000E+00	000E+00	112E+08	491E+04	632E+04	219E+04	000E+00	000E+00	000E+00	000E+00	000E+00	614E+04	000E+00	000E+00	475E+06	390E+07	131E+07	378E+07	133E+07	673E+06	520E+07	185E+07	482E+07	734E+07	837E+06	621E+06	804E+05	936E+06	202E+06	105E+07	730E+06	427E+06	116E+07	465E+06	108E+07	211E+07	209E+06	107E+06	620E+06	401E+06	736E+06	108E+07	897E+06	147E+07	180E+07	154E+07	481E+06	215E+07	698E+06	241E+06
Oxoglutaric acid_C13-label-2	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	612E+07	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	121E+06	196E+07	387E+06	200E+07	292E+06	189E+06	251E+07	513E+06	292E+07	435E+07	000E+00	000E+00	269E+05	530E+06	519E+05	579E+06	166E+06	158E+06	621E+06	139E+06	119E+07	120E+07	000E+00	000E+00	182E+06	114E+06	242E+06	643E+06	286E+06	518E+06	899E+06	549E+06	268E+06	110E+07	249E+04	111E+04
Oxoglutaric acid_C13-label-3	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	277E+07	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	216E+04	291E+04	000E+00	000E+00	495E+04	550E+06	491E+05	540E+06	415E+05	153E+05	745E+06	903E+05	722E+06	148E+07	000E+00	000E+00	000E+00	118E+06	000E+00	139E+06	000E+00	725E+04	104E+06	000E+00	265E+06	320E+06	000E+00	000E+00	557E+05	235E+05	858E+05	195E+06	953E+05	197E+06	364E+06	228E+06	552E+05	462E+06	000E+00	000E+00
Oxoglutaric acid_C13-label-4	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	121E+07	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	103E+06	000E+00	968E+05	000E+00	000E+00	163E+06	799E+04	152E+06	315E+06	000E+00	000E+00	000E+00	000E+00	000E+00	789E+04	000E+00	000E+00	000E+00	000E+00	636E+05	208E+05	000E+00	000E+00	224E+05	518E+04	316E+05	332E+05	273E+05	765E+05	110E+06	904E+05	404E+04	127E+06	000E+00	000E+00
Oxoglutaric acid_C13-label-5	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	864E+06	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	213E+05	000E+00	118E+05	000E+00	000E+00	497E+05	000E+00	161E+05	127E+06	000E+00	000E+00	000E+00	225E+04	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	611E+04	000E+00	124E+05	898E+04	113E+05	489E+05	454E+05	511E+05	000E+00	539E+05	000E+00	000E+00
Succinic acid_PARENT	498E+09	429E+09	335E+09	459E+09	506E+09	552E+09	660E+09	768E+09	458E+09	538E+09	685E+09	402E+09	813E+09	475E+09	468E+09	473E+09	597E+09	582E+09	426E+09	577E+09	488E+09	552E+09	547E+09	622E+09	390E+08	709E+08	577E+08	446E+08	479E+08	453E+08	593E+08	422E+08	478E+08	358E+08	313E+08	432E+08	324E+08	390E+08	249E+08	297E+08	227E+08	196E+08	242E+08	286E+08	283E+08	194E+08	230E+08	184E+08	433E+08	537E+08	375E+08	514E+08	383E+08	314E+08	381E+08	380E+08	263E+08	388E+08	375E+08	349E+08
Succinic acid_C13-label-1	650E+08	647E+08	583E+08	106E+09	503E+08	715E+08	827E+08	751E+08	107E+09	938E+08	310E+08	197E+08	112E+09	119E+09	674E+08	108E+09	705E+08	786E+08	892E+08	751E+08	152E+09	123E+09	246E+08	313E+08	285E+07	143E+08	524E+07	903E+07	332E+07	370E+07	869E+07	317E+07	705E+07	593E+07	135E+07	195E+07	227E+07	499E+07	216E+07	278E+07	141E+07	937E+06	265E+07	212E+07	305E+07	194E+07	997E+06	789E+06	243E+07	489E+07	200E+07	583E+07	202E+07	155E+07	234E+07	198E+07	217E+07	240E+07	166E+07	154E+07
Succinic acid_C13-label-2	189E+08	176E+08	194E+08	367E+08	120E+08	217E+08	180E+08	193E+08	414E+08	281E+08	411E+06	595E+06	651E+08	473E+08	234E+08	390E+08	206E+08	235E+08	310E+08	241E+08	734E+08	498E+08	567E+05	124E+07	540E+06	604E+07	132E+07	390E+07	511E+06	752E+06	328E+07	640E+06	306E+07	276E+07	346E+05	513E+05	253E+06	183E+07	413E+06	738E+06	130E+06	387E+05	768E+06	230E+06	156E+07	577E+06	117E+05	136E+05	338E+06	195E+07	246E+06	278E+07	217E+06	130E+06	514E+06	202E+06	841E+06	627E+06	214E+05	260E+05
Succinic acid_C13-label-3	145E+07	226E+07	211E+07	568E+07	841E+06	176E+07	211E+07	200E+07	644E+07	443E+07	543E+04	000E+00	153E+08	104E+08	439E+07	841E+07	537E+07	491E+07	665E+07	570E+07	216E+08	112E+08	128E+05	291E+05	514E+05	104E+07	143E+06	681E+06	441E+05	731E+05	419E+06	411E+05	542E+06	406E+06	000E+00	000E+00	268E+05	354E+06	414E+05	147E+06	151E+05	000E+00	155E+06	345E+05	395E+06	115E+06	000E+00	000E+00	460E+05	509E+06	327E+05	544E+06	251E+05	168E+05	853E+05	260E+05	131E+06	103E+06	000E+00	000E+00
Succinic acid_C13-label-4	323E+05	219E+06	790E+05	487E+06	191E+05	701E+05	278E+06	930E+05	437E+06	687E+06	000E+00	000E+00	163E+08	178E+07	905E+06	135E+07	689E+06	864E+06	107E+07	976E+06	379E+07	218E+07	230E+04	000E+00	244E+04	198E+06	233E+05	113E+06	000E+00	784E+04	127E+06	773E+04	909E+05	136E+06	000E+00	000E+00	809E+04	557E+05	166E+05	166E+05	000E+00	000E+00	321E+05	304E+04	438E+05	103E+05	000E+00	000E+00	280E+05	130E+06	163E+05	169E+06	128E+05	586E+04	299E+05	506E+04	330E+05	377E+05	000E+00	245E+04
Oxalacetic acid_PARENT	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
Oxalacetic acid_C13-label-1	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
Oxalacetic acid_C13-label-2	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
Oxalacetic acid_C13-label-3	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
Oxalacetic acid_C13-label-4	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Alanine_PARENT	468E+09	436E+09	476E+09	472E+09	494E+09	434E+09	465E+09	492E+09	554E+09	444E+09	525E+09	574E+09	251E+09	297E+09	267E+09	351E+09	221E+09	239E+09	393E+09	269E+09	536E+09	474E+09	407E+09	396E+09	534E+08	639E+08	814E+08	844E+08	760E+08	651E+08	816E+08	706E+08	609E+08	100E+09	812E+08	106E+09	984E+08	122E+09	155E+09	152E+09	111E+09	109E+09	164E+09	104E+09	135E+09	224E+09	144E+09	149E+09	429E+07	126E+08	458E+07	984E+07	336E+07	339E+07	364E+07	282E+07	103E+08	217E+07	284E+07	578E+07
L-Alanine_C13-label-1	242E+08	287E+08	237E+08	310E+08	277E+08	233E+08	276E+08	289E+08	345E+08	279E+08	170E+08	190E+08	124E+08	221E+08	151E+08	265E+08	144E+08	148E+08	296E+08	170E+08	340E+08	252E+08	125E+08	124E+08	292E+07	689E+07	487E+07	818E+07	519E+07	439E+07	814E+07	496E+07	552E+07	882E+07	245E+07	347E+07	521E+07	103E+08	870E+07	108E+08	603E+07	619E+07	121E+08	577E+07	860E+07	134E+08	445E+07	482E+07	262E+06	140E+07	297E+06	123E+07	249E+06	236E+06	454E+06	221E+06	119E+07	195E+06	822E+05	183E+06
L-Alanine_C13-label-2	718E+07	112E+08	715E+07	115E+08	102E+08	785E+07	939E+07	128E+08	111E+08	116E+08	108E+06	466E+06	330E+07	942E+07	510E+07	110E+08	566E+07	543E+07	120E+08	651E+07	105E+08	856E+07	939E+05	400E+06	969E+06	395E+07	184E+07	428E+07	203E+07	181E+07	412E+07	232E+07	239E+07	512E+07	368E+05	136E+06	144E+07	526E+07	279E+07	470E+07	180E+07	197E+07	536E+07	191E+07	313E+07	598E+07	445E+05	128E+06	101E+06	775E+06	119E+06	673E+06	116E+06	146E+06	289E+06	145E+06	625E+06	147E+06	979E+04	208E+05
L-Alanine_C13-label-3	132E+08	181E+08	138E+08	198E+08	169E+08	136E+08	168E+08	247E+08	162E+08	236E+08	000E+00	282E+06	737E+07	170E+08	112E+08	210E+08	930E+07	106E+08	217E+08	118E+08	169E+08	211E+08	000E+00	534E+06	187E+07	687E+07	377E+07	842E+07	346E+07	356E+07	701E+07	412E+07	371E+07	137E+08	000E+00	139E+06	321E+07	989E+07	618E+07	102E+08	318E+07	461E+07	115E+08	388E+07	675E+07	162E+08	000E+00	227E+06	205E+06	125E+07	269E+06	122E+07	207E+06	244E+06	500E+06	234E+06	121E+07	343E+06	000E+00	000E+00
L-Asparagine_PARENT	495E+08	660E+08	516E+08	702E+08	556E+08	541E+08	804E+08	670E+08	762E+08	491E+08	802E+08	708E+08	380E+08	115E+09	658E+08	105E+09	533E+08	677E+08	156E+09	971E+08	228E+09	223E+09	221E+09	141E+09	104E+08	156E+08	147E+08	179E+08	154E+08	142E+08	167E+08	163E+08	141E+08	198E+08	292E+08	270E+08	328E+08	456E+08	409E+08	633E+08	395E+08	413E+08	738E+08	415E+08	617E+08	104E+09	763E+08	618E+08	238E+07	870E+07	224E+07	955E+06	215E+07	193E+07	169E+07	183E+07	119E+07	122E+07	166E+07	272E+07
L-Asparagine_C13-label-1	214E+07	380E+07	268E+07	427E+07	288E+07	275E+07	451E+07	343E+07	374E+07	335E+07	344E+07	295E+07	157E+07	472E+07	283E+07	431E+07	235E+07	283E+07	653E+07	416E+07	934E+07	914E+07	907E+07	559E+07	657E+06	842E+06	773E+06	905E+06	779E+06	727E+06	832E+06	795E+06	661E+06	881E+06	117E+07	106E+07	141E+07	200E+07	185E+07	277E+07	161E+07	163E+07	313E+07	173E+07	256E+07	432E+07	300E+07	246E+07	528E+05	348E+06	490E+05	112E+05	735E+05	449E+05	348E+05	642E+05	568E+05	494E+05	897E+05	120E+06
L-Asparagine_C13-label-2	902E+05	103E+07	618E+06	118E+07	617E+06	568E+06	129E+07	106E+07	269E+06	959E+06	784E+05	371E+05	390E+05	765E+05	107E+06	626E+05	112E+06	685E+05	929E+05	823E+05	424E+05	312E+05	309E+05	139E+05	482E+05	639E+05	299E+05	344E+05	227E+05	277E+05	212E+05	896E+04	283E+05	183E+05	334E+04	207E+04	186E+05	326E+05	415E+05	960E+05	388E+04	214E+05	308E+05	123E+05	242E+05	313E+05	117E+05	124E+05	103E+04	192E+04	995E+03	972E+03	294E+04	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Asparagine_C13-label-3	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Asparagine_C13-label-4	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00	000E+00
L-Glutamic acid_PARENT	156E+10	401E+09	114E+10	351E+09	103E+10	162E+10	495E+09	177E+10	438E+09	400E+09	638E+09	105E+10	688E+09	169E+10	235E+10	158E+10	258E+10	232E+10	208E+10	247E+10	198E+10	167E+10	251E+10	289E+10	234E+09	196E+09	319E+09	209E+09	354E+09	320E+09	369E+09	350E+09	177E+09	316E+09	352E+09	415E+09	104E+10	539E+09	130E+10	615E+09	127E+10	111E+10	724E+09	113E+10	576E+09	702E+09	127E+10	130E+10	251E+08	447E+08	221E+08	276E+08	194E+08	183E+08	195E+08	204E+08	296E+08	128E+08	139E+08	188E+08
L-Glutamic acid_C13-label-1	222E+09	733E+08	211E+09	868E+08	115E+09	225E+09	704E+08	188E+09	106E+09	766E+08	356E+08	632E+08	966E+08	346E+09	350E+09	303E+09	323E+09	328E+09	370E+09	329E+09	386E+09	275E+09	140E+09	184E+09	279E+08	484E+08	424E+08	529E+08	413E+08	426E+08	758E+08	439E+08	408E+08	680E+08	199E+08	249E+08	160E+09	126E+09	220E+09	135E+09	174E+09	186E+09	153E+09	167E+09	125E+09	132E+09	711E+08	831E+08	201E+07	388E+07	193E+07	420E+07	157E+07	151E+07	205E+07	175E+07	379E+07	117E+07	690E+06	103E+07
L-Glutamic acid_C13-label-2	853E+08	294E+08	975E+08	413E+08	351E+08	917E+08	232E+08	594E+08	547E+08	331E+08	381E+06	197E+07	444E+08	195E+09	166E+09	162E+09	113E+09	135E+09	189E+09	127E+09	270E+09	143E+09	121E+07	104E+08	714E+07	252E+08	129E+08	290E+08	988E+07	122E+08	375E+08	120E+08	255E+08	422E+08	293E+06	792E+06	427E+08	765E+08	722E+08	768E+08	386E+08	559E+08	759E+08	400E+08	135E+09	770E+08	809E+06	292E+07	587E+06	133E+07	670E+06	261E+07	517E+06	516E+06	103E+07	617E+06	228E+07	553E+06	199E+04	569E+05
L-Glutamic acid_C13-label-3	805E+07	579E+07	119E+08	883E+07	338E+07	913E+07	401E+07	575E+07	961E+07	796E+07	000E+00	278E+05	183E+08	684E+08	515E+08	535E+08	388E+08	449E+08	654E+08	461E+08	857E+08	534E+08	000E+00	114E+07	122E+07	719E+07	219E+07	767E+07	182E+07	223E+07	117E+08	244E+07	658E+07	147E+08	000E+00	414E+05	800E+07	196E+08	153E+08	193E+08	746E+07	114E+08	185E+08	831E+07	341E+08	193E+08	000E+00	606E+05	204E+06	471E+06	238E+06	861E+06	184E+06	215E+06	393E+06	259E+06	606E+06	244E+06	000E+00	113E+04
L-Glutamic acid_C13-label-4	120E+07	116E+07	209E+07	173E+07	501E+06	153E+07	817E+06	991E+06	173E+07	178E+07	000E+00	000E+00	751E+07	116E+08	166E+08	976E+07	991E+07	127E+08	153E+08	131E+08	249E+08	924E+07	000E+00	000E+00	208E+06	142E+07	385E+06	153E+07	273E+06	357E+06	250E+07	394E+06	144E+07	316E+07	000E+00	000E+00	152E+07	466E+07	307E+07	424E+07	130E+07	209E+07	387E+07	157E+07	129E+08	417E+07	000E+00	000E+00	867E+05	114E+06	113E+06	208E+06	730E+05	721E+05	128E+06	109E+06	137E+06	559E+05	000E+00	000E+00
L-Glutamic acid_C13-label-5	235E+06	322E+06	359E+06	456E+06	159E+06	391E+06	307E+06	508E+06	185E+06	599E+06	000E+00	000E+00	463E+07	470E+07	918E+07	363E+07	605E+07	707E+07	668E+07	821E+07	660E+07	343E+07	000E+00	132E+05	000E+00	233E+06	241E+05	216E+06	266E+05	311E+05	834E+06	104E+06	211E+06	117E+07	000E+00	000E+00	612E+06	933E+06	138E+07	855E+06	623E+06	849E+06	951E+06	825E+06	164E+07	904E+06	000E+00	000E+00	148E+05	154E+05	197E+05	489E+05	865E+04	964E+04	268E+05	287E+05	106E+05	644E+04	000E+00	000E+00
L-Glutamine_PARENT	154E+10	273E+10	172E+10	271E+10	161E+10	161E+10	307E+10	203E+10	304E+10	316E+10	410E+10	285E+10	260E+09	618E+09	459E+09	491E+09	408E+09	382E+09	755E+09	484E+09	831E+09	726E+09	745E+09	744E+09	171E+09	200E+09	251E+09	282E+09	259E+09	240E+09	114E+09	260E+09	162E+09	122E+09	369E+09	358E+09	254E+09	300E+09	331E+09	290E+09	324E+09	273E+09	366E+09	321E+09	311E+09	419E+09	501E+09	386E+09	249E+08	505E+08	322E+08	234E+08	350E+08	301E+08	255E+08	290E+08	315E+08	167E+08	515E+08	497E+08
L-Glutamine_C13-label-1	180E+09	488E+09	223E+09	591E+09	190E+09	208E+09	474E+09	239E+09	617E+09	479E+09	228E+09	176E+09	284E+08	996E+08	538E+08	727E+08	444E+08	444E+08	115E+09	518E+08	104E+09	801E+08	407E+08	445E+08	199E+08	426E+08	315E+08	593E+08	304E+08	311E+08	231E+08	326E+08	336E+08	231E+08	205E+08	215E+08	276E+08	462E+08	384E+08	424E+08	352E+08	319E+08	535E+08	362E+08	442E+08	534E+08	278E+08	230E+08	229E+07	618E+07	322E+07	349E+07	346E+07	301E+07	325E+07	297E+07	430E+07	172E+07	268E+07	290E+07
L-Glutamine_C13-label-2	764E+08	350E+09	106E+09	433E+09	838E+08	102E+09	310E+09	117E+09	446E+09	317E+09	195E+07	106E+08	890E+07	521E+08	207E+08	379E+08	142E+08	157E+08	541E+08	174E+08	533E+08	343E+08	487E+06	184E+07	643E+07	283E+08	118E+08	396E+08	102E+08	119E+08	138E+08	121E+08	263E+08	162E+08	270E+06	990E+06	845E+07	270E+08	138E+08	249E+08	109E+08	111E+08	270E+08	125E+08	323E+08	302E+08	366E+06	952E+06	813E+06	330E+07	129E+07	212E+07	132E+07	126E+07	188E+07	122E+07	271E+07	924E+06	178E+05	226E+06
L-Glutamine_C13-label-3	294E+08	170E+09	422E+08	189E+09	370E+08	427E+08	151E+09	582E+08	134E+09	152E+09	000E+00	140E+07	270E+07	197E+08	598E+07	133E+08	468E+07	502E+07	187E+08	610E+07	159E+08	130E+08	000E+00	790E+05	178E+07	113E+08	351E+07	148E+08	335E+07	377E+07	504E+07	426E+07	809E+07	676E+07	000E+00	125E+06	257E+07	100E+08	434E+07	844E+07	365E+07	359E+07	940E+07	443E+07	891E+07	112E+08	000E+00	605E+05	319E+06	142E+07	530E+06	887E+06	536E+06	537E+06	796E+06	546E+06	846E+06	414E+06	000E+00	191E+05
L-Glutamine_C13-label-4	134E+08	735E+08	192E+08	747E+08	153E+08	182E+08	706E+08	287E+08	370E+08	624E+08	000E+00	853E+04	912E+06	451E+07	192E+07	319E+07	136E+07	149E+07	449E+07	194E+07	353E+07	285E+07	000E+00	000E+00	598E+06	298E+07	113E+07	385E+07	999E+06	108E+07	132E+07	141E+07	192E+07	165E+07	000E+00	000E+00	905E+06	274E+07	152E+07	222E+07	118E+07	114E+07	240E+07	155E+07	224E+07	271E+07	000E+00	000E+00	141E+06	416E+06	239E+06	244E+06	203E+06	209E+06	262E+06	224E+06	192E+06	126E+06	000E+00	000E+00
L-Glutamine_C13-label-5	832E+07	320E+08	118E+08	301E+08	962E+07	112E+08	355E+08	194E+08	661E+07	271E+08	000E+00	000E+00	525E+06	193E+07	105E+07	126E+07	855E+06	841E+06	201E+07	120E+07	897E+06	126E+07	000E+00	000E+00	380E+06	127E+07	654E+06	153E+07	601E+06	635E+06	613E+06	876E+06	525E+06	770E+06	000E+00	000E+00	551E+06	116E+07	892E+06	916E+06	713E+06	656E+06	105E+07	974E+06	499E+06	116E+07	000E+00	000E+00	124E+06	239E+06	193E+06	166E+06	170E+06	168E+06	178E+06	197E+06	912E+05	110E+06	000E+00	000E+00
L-Aspartic acid_PARENT	303E+09	144E+09	194E+09	837E+08	316E+09	335E+09	124E+09	301E+09	128E+09	611E+08	277E+09	180E+09	441E+08	421E+09	839E+09	368E+09	881E+09	791E+09	717E+09	847E+09	637E+09	545E+09	127E+10	116E+10	228E+09	151E+09	273E+09	177E+09	307E+09	273E+09	178E+09	296E+09	140E+09	134E+09	295E+09	391E+09	976E+09	469E+09	114E+10	473E+09	996E+09	103E+10	586E+09	881E+09	454E+09	498E+09	927E+09	133E+10	906E+07	318E+08	786E+07	106E+08	499E+07	557E+07	428E+07	541E+07	126E+08	243E+07	416E+07	845E+07
L-Aspartic acid_C13-label-1	371E+08	218E+08	302E+08	178E+08	307E+08	403E+08	155E+08	282E+08	289E+08	951E+07	120E+08	813E+07	426E+07	846E+08	109E+09	646E+08	997E+08	978E+08	132E+09	994E+08	125E+09	816E+08	573E+08	569E+08	235E+08	335E+08	316E+08	362E+08	313E+08	318E+08	302E+08	336E+08	284E+08	245E+08	132E+08	191E+08	157E+09	102E+09	205E+09	946E+08	135E+09	183E+09	120E+09	128E+09	889E+08	816E+08	420E+08	727E+08	615E+06	237E+07	609E+06	108E+07	362E+06	402E+06	368E+06	397E+06	128E+07	214E+06	170E+06	365E+06
L-Aspartic acid_C13-label-2	109E+08	577E+07	983E+07	600E+07	728E+07	120E+08	334E+07	655E+07	110E+08	253E+07	139E+06	241E+06	110E+07	284E+08	320E+08	201E+08	262E+08	268E+08	417E+08	289E+08	510E+08	276E+08	661E+06	181E+07	432E+07	135E+08	715E+07	152E+08	605E+07	741E+07	998E+07	769E+07	128E+08	119E+08	177E+06	581E+06	389E+08	494E+08	602E+08	410E+08	267E+08	523E+08	476E+08	263E+08	681E+08	361E+08	517E+06	282E+07	118E+06	626E+06	144E+06	416E+06	776E+05	908E+05	112E+06	105E+06	465E+06	491E+05	000E+00	722E+04
L-Aspartic acid_C13-label-3	829E+06	794E+06	993E+06	896E+06	547E+06	103E+07	378E+06	664E+06	167E+07	392E+06	000E+00	000E+00	431E+06	749E+07	671E+07	493E+07	790E+07	594E+07	112E+08	781E+07	149E+08	691E+07	000E+00	323E+05	836E+06	344E+07	152E+07	365E+07	151E+07	190E+07	232E+07	218E+07	319E+07	338E+07	000E+00	000E+00	496E+07	115E+08	892E+07	907E+07	324E+07	742E+07	101E+08	343E+07	189E+08	794E+07	000E+00	000E+00	289E+05	224E+06	349E+05	126E+06	141E+05	132E+05	194E+05	218E+05	160E+06	875E+04	000E+00	102E+04
L-Aspartic acid_C13-label-4	400E+04	113E+06	149E+05	811E+05	000E+00	141E+05	274E+05	888E+04	103E+06	586E+05	000E+00	000E+00	111E+06	112E+07	101E+07	776E+06	750E+06	915E+06	161E+07	104E+07	243E+07	128E+07	000E+00	000E+00	126E+06	589E+06	218E+06	633E+06	167E+06	213E+06	397E+06	283E+06	495E+06	915E+06	000E+00	000E+00	142E+07	172E+07	242E+07	127E+07	900E+06	178E+07	169E+07	116E+07	190E+07	120E+07	000E+00	000E+00	307E+04	458E+05	545E+04	253E+05	000E+00	512E+04	111E+04	436E+04	247E+05	325E+04	000E+00	000E+00
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name
L-Lactic acid_PARENT
L-Lactic acid_C13-label-1
L-Lactic acid_C13-label-2
L-Lactic acid_C13-label-3
D-Glyceraldehyde 3-phosphate_PARENT
D-Glyceraldehyde 3-phosphate_C13-label-1
D-Glyceraldehyde 3-phosphate_C13-label-2
D-Glyceraldehyde 3-phosphate_C13-label-3
Pyruvic acid_PARENT
Pyruvic acid_C13-label-1
Pyruvic acid_C13-label-2
Pyruvic acid_C13-label-3
Citric acid_PARENT
Citric acid_C13-label-1
Citric acid_C13-label-2
Citric acid_C13-label-3
Citric acid_C13-label-4
Citric acid_C13-label-5
Citric acid_C13-label-6
Fumaric acid_PARENT
Fumaric acid_C13-label-1
Fumaric acid_C13-label-2
Fumaric acid_C13-label-3
Fumaric acid_C13-label-4
L-Malic acid_PARENT
L-Malic acid_C13-label-1
L-Malic acid_C13-label-2
L-Malic acid_C13-label-3
L-Malic acid_C13-label-4
Oxoglutaric acid_PARENT
Oxoglutaric acid_C13-label-1
Oxoglutaric acid_C13-label-2
Oxoglutaric acid_C13-label-3
Oxoglutaric acid_C13-label-4
Oxoglutaric acid_C13-label-5
Succinic acid_PARENT
Succinic acid_C13-label-1
Succinic acid_C13-label-2
Succinic acid_C13-label-3
Succinic acid_C13-label-4
Oxalacetic acid_PARENT
Oxalacetic acid_C13-label-1
Oxalacetic acid_C13-label-2
Oxalacetic acid_C13-label-3
Oxalacetic acid_C13-label-4
L-Alanine_PARENT
L-Alanine_C13-label-1
L-Alanine_C13-label-2
L-Alanine_C13-label-3
L-Asparagine_PARENT
L-Asparagine_C13-label-1
L-Asparagine_C13-label-2
L-Asparagine_C13-label-3
L-Asparagine_C13-label-4
L-Glutamic acid_PARENT
L-Glutamic acid_C13-label-1
L-Glutamic acid_C13-label-2
L-Glutamic acid_C13-label-3
L-Glutamic acid_C13-label-4
L-Glutamic acid_C13-label-5
L-Glutamine_PARENT
L-Glutamine_C13-label-1
L-Glutamine_C13-label-2
L-Glutamine_C13-label-3
L-Glutamine_C13-label-4
L-Glutamine_C13-label-5
L-Aspartic acid_PARENT
L-Aspartic acid_C13-label-1
L-Aspartic acid_C13-label-2
L-Aspartic acid_C13-label-3
L-Aspartic acid_C13-label-4
METABOLITES_END
#END