#METABOLOMICS WORKBENCH ZJ309_20250708_021343 DATATRACK_ID:6145 STUDY_ID:ST004034 ANALYSIS_ID:AN006671 PROJECT_ID:PR002526 VERSION 1 CREATED_ON July 9, 2025, 12:47 am #PROJECT PR:PROJECT_TITLE A Multi-Tissue Lipidome and Adipose Proteome Atlas Reveals Perinatal Bisphenol S PR:PROJECT_TITLE Exposure Primes Offspring for High-Fat Diet-Induced Obesity and Insulin PR:PROJECT_TITLE Resistance PR:PROJECT_SUMMARY Due to increasingly strict regulations on the use of bisphenol A (BPA), its PR:PROJECT_SUMMARY structurally similar alternative, bisphenol S (BPS), has been widely used as a PR:PROJECT_SUMMARY major substitute in many industries, including food packaging. However, recent PR:PROJECT_SUMMARY studies have revealed that BPS may promote obesity and lead to insulin PR:PROJECT_SUMMARY resistance, especially in the early stages of life, although its exact impact is PR:PROJECT_SUMMARY not yet fully understood. To address these concerns, this study established a PR:PROJECT_SUMMARY mouse model to explore the exposure of female mice to BPS during pregnancy and PR:PROJECT_SUMMARY lactation, as well as the consumption of high-fat diets by their offspring. By PR:PROJECT_SUMMARY evaluating the biological phenotypes related to obesity and insulin resistance PR:PROJECT_SUMMARY in the offspring mice, multi-tissue lipidomics analysis and adipose tissue PR:PROJECT_SUMMARY proteomics analysis were carried out. Ultimately, a correlation study was PR:PROJECT_SUMMARY conducted by combining phenotypes, lipidomics, and proteomics to explore the PR:PROJECT_SUMMARY risks and potential mechanisms of BPS exposure to obesity and insulin PR:PROJECT_SUMMARY resistance. PR:INSTITUTE Jimei University PR:LAST_NAME Li PR:FIRST_NAME Shuyin PR:ADDRESS No. 185 Yinjiang Road, Jimei District, Xiamen City, Fujian Province, China PR:EMAIL 164000107@qq.com PR:PHONE 18750682266 #STUDY ST:STUDY_TITLE A Multi-Tissue Lipidome and Adipose Proteome Atlas Reveals Perinatal Bisphenol S ST:STUDY_TITLE Exposure Primes Offspring for High-Fat Diet-Induced Obesity and Insulin ST:STUDY_TITLE Resistance ST:STUDY_SUMMARY Due to increasingly strict regulations on the use of bisphenol A (BPA), its ST:STUDY_SUMMARY structurally similar alternative, bisphenol S (BPS), has been widely used as a ST:STUDY_SUMMARY major substitute in many industries, including food packaging. However, recent ST:STUDY_SUMMARY studies have revealed that BPS may promote obesity and lead to insulin ST:STUDY_SUMMARY resistance, especially in the early stages of life, although its exact impact is ST:STUDY_SUMMARY not yet fully understood. To address these concerns, this study established a ST:STUDY_SUMMARY mouse model to explore the exposure of female mice to BPS during pregnancy and ST:STUDY_SUMMARY lactation, as well as the consumption of high-fat diets by their offspring. By ST:STUDY_SUMMARY evaluating the biological phenotypes related to obesity and insulin resistance ST:STUDY_SUMMARY in the offspring mice, multi-tissue lipidomics analysis and adipose tissue ST:STUDY_SUMMARY proteomics analysis were carried out. Ultimately, a correlation study was ST:STUDY_SUMMARY conducted by combining phenotypes, lipidomics, and proteomics to explore the ST:STUDY_SUMMARY risks and potential mechanisms of BPS exposure to obesity and insulin ST:STUDY_SUMMARY resistance. ST:INSTITUTE Jimei University ST:LAST_NAME Li ST:FIRST_NAME Shuyin ST:ADDRESS No.185 Yinjiang Road,Jimei District,Xiamen City,Fujian Province,China ST:EMAIL 164000107@qq.com ST:PHONE 18750682266 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #FACTORS #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - BCF-223 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-223.raw SUBJECT_SAMPLE_FACTORS - BCF-226 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-226.raw SUBJECT_SAMPLE_FACTORS - BCF-227 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-227.raw SUBJECT_SAMPLE_FACTORS - BCF-228 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-228.raw SUBJECT_SAMPLE_FACTORS - BCF-229 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-229.raw SUBJECT_SAMPLE_FACTORS - BCF-230 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-230.raw SUBJECT_SAMPLE_FACTORS - BCF-231 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCF-231.raw SUBJECT_SAMPLE_FACTORS - BCM-233 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-233.raw SUBJECT_SAMPLE_FACTORS - BCM-234 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-234.raw SUBJECT_SAMPLE_FACTORS - BCM-236 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-236.raw SUBJECT_SAMPLE_FACTORS - BCM-237 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-237.raw SUBJECT_SAMPLE_FACTORS - BCM-238 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-238.raw SUBJECT_SAMPLE_FACTORS - BCM-243 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-243.raw SUBJECT_SAMPLE_FACTORS - BCM-246 BPS Treatment:Control | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BCM-246.raw SUBJECT_SAMPLE_FACTORS - BHF-295 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-295.raw SUBJECT_SAMPLE_FACTORS - BHF-297 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-297.raw SUBJECT_SAMPLE_FACTORS - BHF-298 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-298.raw SUBJECT_SAMPLE_FACTORS - BHF-299 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-299.raw SUBJECT_SAMPLE_FACTORS - BHF-306 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-306.raw SUBJECT_SAMPLE_FACTORS - BHF-307 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-307.raw SUBJECT_SAMPLE_FACTORS - BHF-4413 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4413.raw SUBJECT_SAMPLE_FACTORS - BHF-4415 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4415.raw SUBJECT_SAMPLE_FACTORS - BHF-4416 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4416.raw SUBJECT_SAMPLE_FACTORS - BHF-4417 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4417.raw SUBJECT_SAMPLE_FACTORS - BHF-4418 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4418.raw SUBJECT_SAMPLE_FACTORS - BHF-4419 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4419.raw SUBJECT_SAMPLE_FACTORS - BHF-4438 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHF-4438.raw SUBJECT_SAMPLE_FACTORS - BHM-289 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-289.raw SUBJECT_SAMPLE_FACTORS - BHM-290 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-290.raw SUBJECT_SAMPLE_FACTORS - BHM-294 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-294.raw SUBJECT_SAMPLE_FACTORS - BHM-300 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-300.raw SUBJECT_SAMPLE_FACTORS - BHM-301 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-301.raw SUBJECT_SAMPLE_FACTORS - BHM-304 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-304.raw SUBJECT_SAMPLE_FACTORS - BHM-305 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-305.raw SUBJECT_SAMPLE_FACTORS - BHM-4423 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4423.raw SUBJECT_SAMPLE_FACTORS - BHM-4427 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4427.raw SUBJECT_SAMPLE_FACTORS - BHM-4431 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4431.raw SUBJECT_SAMPLE_FACTORS - BHM-4432 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4432.raw SUBJECT_SAMPLE_FACTORS - BHM-4433 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4433.raw SUBJECT_SAMPLE_FACTORS - BHM-4434 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4434.raw SUBJECT_SAMPLE_FACTORS - BHM-4452 BPS Treatment:5mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BHM-4452.raw SUBJECT_SAMPLE_FACTORS - BLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-258.raw SUBJECT_SAMPLE_FACTORS - BLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-261.raw SUBJECT_SAMPLE_FACTORS - BLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-262.raw SUBJECT_SAMPLE_FACTORS - BLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-263.raw SUBJECT_SAMPLE_FACTORS - BLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-264.raw SUBJECT_SAMPLE_FACTORS - BLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-266.raw SUBJECT_SAMPLE_FACTORS - BLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLF-267.raw SUBJECT_SAMPLE_FACTORS - BLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-247.raw SUBJECT_SAMPLE_FACTORS - BLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-252.raw SUBJECT_SAMPLE_FACTORS - BLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-253.raw SUBJECT_SAMPLE_FACTORS - BLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-255.raw SUBJECT_SAMPLE_FACTORS - BLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-275.raw SUBJECT_SAMPLE_FACTORS - BLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-278.raw SUBJECT_SAMPLE_FACTORS - BLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Brown Adipose Tissue RAW_FILE_NAME(Raw filename)=BLM-279.raw SUBJECT_SAMPLE_FACTORS - HCF-223 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-223.raw SUBJECT_SAMPLE_FACTORS - HCF-226 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-226.raw SUBJECT_SAMPLE_FACTORS - HCF-227 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-227.raw SUBJECT_SAMPLE_FACTORS - HCF-228 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-228.raw SUBJECT_SAMPLE_FACTORS - HCF-229 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-229.raw SUBJECT_SAMPLE_FACTORS - HCF-230 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-230.raw SUBJECT_SAMPLE_FACTORS - HCF-231 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCF-231.raw SUBJECT_SAMPLE_FACTORS - HCM-233 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-233.raw SUBJECT_SAMPLE_FACTORS - HCM-234 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-234.raw SUBJECT_SAMPLE_FACTORS - HCM-236 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-236.raw SUBJECT_SAMPLE_FACTORS - HCM-237 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-237.raw SUBJECT_SAMPLE_FACTORS - HCM-238 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-238.raw SUBJECT_SAMPLE_FACTORS - HCM-243 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-243.raw SUBJECT_SAMPLE_FACTORS - HCM-246 BPS Treatment:Control | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HCM-246.raw SUBJECT_SAMPLE_FACTORS - HHF-295 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-295.raw SUBJECT_SAMPLE_FACTORS - HHF-297 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-297.raw SUBJECT_SAMPLE_FACTORS - HHF-298 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-298.raw SUBJECT_SAMPLE_FACTORS - HHF-299 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-299.raw SUBJECT_SAMPLE_FACTORS - HHF-306 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-306.raw SUBJECT_SAMPLE_FACTORS - HHF-307 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-307.raw SUBJECT_SAMPLE_FACTORS - HHF-4413 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4413.raw SUBJECT_SAMPLE_FACTORS - HHF-4415 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4415.raw SUBJECT_SAMPLE_FACTORS - HHF-4416 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4416.raw SUBJECT_SAMPLE_FACTORS - HHF-4417 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4417.raw SUBJECT_SAMPLE_FACTORS - HHF-4418 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4418.raw SUBJECT_SAMPLE_FACTORS - HHF-4419 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4419.raw SUBJECT_SAMPLE_FACTORS - HHF-4438 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHF-4438.raw SUBJECT_SAMPLE_FACTORS - HHM-289 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-289.raw SUBJECT_SAMPLE_FACTORS - HHM-290 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-290.raw SUBJECT_SAMPLE_FACTORS - HHM-294 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-294.raw SUBJECT_SAMPLE_FACTORS - HHM-300 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-300.raw SUBJECT_SAMPLE_FACTORS - HHM-301 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-301.raw SUBJECT_SAMPLE_FACTORS - HHM-304 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-304.raw SUBJECT_SAMPLE_FACTORS - HHM-305 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-305.raw SUBJECT_SAMPLE_FACTORS - HHM-4423 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4423.raw SUBJECT_SAMPLE_FACTORS - HHM-4427 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4427.raw SUBJECT_SAMPLE_FACTORS - HHM-4431 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4431.raw SUBJECT_SAMPLE_FACTORS - HHM-4432 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4432.raw SUBJECT_SAMPLE_FACTORS - HHM-4433 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4433.raw SUBJECT_SAMPLE_FACTORS - HHM-4434 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4434.raw SUBJECT_SAMPLE_FACTORS - HHM-4452 BPS Treatment:5mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HHM-4452.raw SUBJECT_SAMPLE_FACTORS - HLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-258.raw SUBJECT_SAMPLE_FACTORS - HLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-261.raw SUBJECT_SAMPLE_FACTORS - HLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-262.raw SUBJECT_SAMPLE_FACTORS - HLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-263.raw SUBJECT_SAMPLE_FACTORS - HLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-264.raw SUBJECT_SAMPLE_FACTORS - HLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-266.raw SUBJECT_SAMPLE_FACTORS - HLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLF-267.raw SUBJECT_SAMPLE_FACTORS - HLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-247.raw SUBJECT_SAMPLE_FACTORS - HLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-252.raw SUBJECT_SAMPLE_FACTORS - HLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-253.raw SUBJECT_SAMPLE_FACTORS - HLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-255.raw SUBJECT_SAMPLE_FACTORS - HLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-275.raw SUBJECT_SAMPLE_FACTORS - HLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-278.raw SUBJECT_SAMPLE_FACTORS - HLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Heart Tissue RAW_FILE_NAME(Raw filename)=HLM-279.raw SUBJECT_SAMPLE_FACTORS - LCF-223 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-223.raw SUBJECT_SAMPLE_FACTORS - LCF-226 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-226.raw SUBJECT_SAMPLE_FACTORS - LCF-227 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-227.raw SUBJECT_SAMPLE_FACTORS - LCF-228 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-228.raw SUBJECT_SAMPLE_FACTORS - LCF-229 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-229.raw SUBJECT_SAMPLE_FACTORS - LCF-230 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-230.raw SUBJECT_SAMPLE_FACTORS - LCF-231 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCF-231.raw SUBJECT_SAMPLE_FACTORS - LCM-233 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-233.raw SUBJECT_SAMPLE_FACTORS - LCM-234 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-234.raw SUBJECT_SAMPLE_FACTORS - LCM-236 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-236.raw SUBJECT_SAMPLE_FACTORS - LCM-237 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-237.raw SUBJECT_SAMPLE_FACTORS - LCM-238 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-238.raw SUBJECT_SAMPLE_FACTORS - LCM-243 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-243.raw SUBJECT_SAMPLE_FACTORS - LCM-246 BPS Treatment:Control | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LCM-246.raw SUBJECT_SAMPLE_FACTORS - LHF-295 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-295.raw SUBJECT_SAMPLE_FACTORS - LHF-297 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-297.raw SUBJECT_SAMPLE_FACTORS - LHF-298 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-298.raw SUBJECT_SAMPLE_FACTORS - LHF-299 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-299.raw SUBJECT_SAMPLE_FACTORS - LHF-306 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-306.raw SUBJECT_SAMPLE_FACTORS - LHF-307 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-307.raw SUBJECT_SAMPLE_FACTORS - LHF-4413 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4413.raw SUBJECT_SAMPLE_FACTORS - LHF-4415 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4415.raw SUBJECT_SAMPLE_FACTORS - LHF-4416 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4416.raw SUBJECT_SAMPLE_FACTORS - LHF-4417 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4417.raw SUBJECT_SAMPLE_FACTORS - LHF-4418 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4418.raw SUBJECT_SAMPLE_FACTORS - LHF-4419 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4419.raw SUBJECT_SAMPLE_FACTORS - LHF-4438 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHF-4438.raw SUBJECT_SAMPLE_FACTORS - LHM-289 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-289.raw SUBJECT_SAMPLE_FACTORS - LHM-290 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-290.raw SUBJECT_SAMPLE_FACTORS - LHM-294 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-294.raw SUBJECT_SAMPLE_FACTORS - LHM-300 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-300.raw SUBJECT_SAMPLE_FACTORS - LHM-301 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-301.raw SUBJECT_SAMPLE_FACTORS - LHM-304 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-304.raw SUBJECT_SAMPLE_FACTORS - LHM-305 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-305.raw SUBJECT_SAMPLE_FACTORS - LHM-4423 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4423.raw SUBJECT_SAMPLE_FACTORS - LHM-4427 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4427.raw SUBJECT_SAMPLE_FACTORS - LHM-4431 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4431.raw SUBJECT_SAMPLE_FACTORS - LHM-4432 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4432.raw SUBJECT_SAMPLE_FACTORS - LHM-4433 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4433.raw SUBJECT_SAMPLE_FACTORS - LHM-4434 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4434.raw SUBJECT_SAMPLE_FACTORS - LHM-4452 BPS Treatment:5mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LHM-4452.raw SUBJECT_SAMPLE_FACTORS - LLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-258.raw SUBJECT_SAMPLE_FACTORS - LLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-261.raw SUBJECT_SAMPLE_FACTORS - LLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-262.raw SUBJECT_SAMPLE_FACTORS - LLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-263.raw SUBJECT_SAMPLE_FACTORS - LLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-264.raw SUBJECT_SAMPLE_FACTORS - LLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-266.raw SUBJECT_SAMPLE_FACTORS - LLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLF-267.raw SUBJECT_SAMPLE_FACTORS - LLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-247.raw SUBJECT_SAMPLE_FACTORS - LLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-252.raw SUBJECT_SAMPLE_FACTORS - LLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-253.raw SUBJECT_SAMPLE_FACTORS - LLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-255.raw SUBJECT_SAMPLE_FACTORS - LLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-275.raw SUBJECT_SAMPLE_FACTORS - LLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-278.raw SUBJECT_SAMPLE_FACTORS - LLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Liver Tissue RAW_FILE_NAME(Raw filename)=LLM-279.raw SUBJECT_SAMPLE_FACTORS - PCF-223 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-223.raw SUBJECT_SAMPLE_FACTORS - PCF-226 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-226.raw SUBJECT_SAMPLE_FACTORS - PCF-227 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-227.raw SUBJECT_SAMPLE_FACTORS - PCF-228 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-228.raw SUBJECT_SAMPLE_FACTORS - PCF-229 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-229.raw SUBJECT_SAMPLE_FACTORS - PCF-230 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-230.raw SUBJECT_SAMPLE_FACTORS - PCF-231 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCF-231.raw SUBJECT_SAMPLE_FACTORS - PCM-233 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-233.raw SUBJECT_SAMPLE_FACTORS - PCM-234 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-234.raw SUBJECT_SAMPLE_FACTORS - PCM-236 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-236.raw SUBJECT_SAMPLE_FACTORS - PCM-237 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-237.raw SUBJECT_SAMPLE_FACTORS - PCM-238 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-238.raw SUBJECT_SAMPLE_FACTORS - PCM-243 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-243.raw SUBJECT_SAMPLE_FACTORS - PCM-246 BPS Treatment:Control | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PCM-246.raw SUBJECT_SAMPLE_FACTORS - PHF-295 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-295.raw SUBJECT_SAMPLE_FACTORS - PHF-297 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-297.raw SUBJECT_SAMPLE_FACTORS - PHF-298 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-298.raw SUBJECT_SAMPLE_FACTORS - PHF-299 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-299.raw SUBJECT_SAMPLE_FACTORS - PHF-306 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-306.raw SUBJECT_SAMPLE_FACTORS - PHF-307 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-307.raw SUBJECT_SAMPLE_FACTORS - PHF-4413 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4413.raw SUBJECT_SAMPLE_FACTORS - PHF-4415 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4415.raw SUBJECT_SAMPLE_FACTORS - PHF-4416 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4416.raw SUBJECT_SAMPLE_FACTORS - PHF-4417 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4417.raw SUBJECT_SAMPLE_FACTORS - PHF-4418 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4418.raw SUBJECT_SAMPLE_FACTORS - PHF-4419 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4419.raw SUBJECT_SAMPLE_FACTORS - PHF-4438 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHF-4438.raw SUBJECT_SAMPLE_FACTORS - PHM-289 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-289.raw SUBJECT_SAMPLE_FACTORS - PHM-290 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-290.raw SUBJECT_SAMPLE_FACTORS - PHM-294 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-294.raw SUBJECT_SAMPLE_FACTORS - PHM-300 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-300.raw SUBJECT_SAMPLE_FACTORS - PHM-301 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-301.raw SUBJECT_SAMPLE_FACTORS - PHM-304 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-304.raw SUBJECT_SAMPLE_FACTORS - PHM-305 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-305.raw SUBJECT_SAMPLE_FACTORS - PHM-4423 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4423.raw SUBJECT_SAMPLE_FACTORS - PHM-4427 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4427.raw SUBJECT_SAMPLE_FACTORS - PHM-4431 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4431.raw SUBJECT_SAMPLE_FACTORS - PHM-4432 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4432.raw SUBJECT_SAMPLE_FACTORS - PHM-4433 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4433.raw SUBJECT_SAMPLE_FACTORS - PHM-4434 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4434.raw SUBJECT_SAMPLE_FACTORS - PHM-4452 BPS Treatment:5mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PHM-4452.raw SUBJECT_SAMPLE_FACTORS - PLF-258 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-258.raw SUBJECT_SAMPLE_FACTORS - PLF-261 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-261.raw SUBJECT_SAMPLE_FACTORS - PLF-262 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-262.raw SUBJECT_SAMPLE_FACTORS - PLF-263 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-263.raw SUBJECT_SAMPLE_FACTORS - PLF-264 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-264.raw SUBJECT_SAMPLE_FACTORS - PLF-266 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-266.raw SUBJECT_SAMPLE_FACTORS - PLF-267 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLF-267.raw SUBJECT_SAMPLE_FACTORS - PLM-247 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-247.raw SUBJECT_SAMPLE_FACTORS - PLM-252 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-252.raw SUBJECT_SAMPLE_FACTORS - PLM-253 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-253.raw SUBJECT_SAMPLE_FACTORS - PLM-255 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-255.raw SUBJECT_SAMPLE_FACTORS - PLM-275 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-275.raw SUBJECT_SAMPLE_FACTORS - PLM-278 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-278.raw SUBJECT_SAMPLE_FACTORS - PLM-279 BPS Treatment:0.05mg/kg/d | Sample source:Pancreas Tissue RAW_FILE_NAME(Raw filename)=PLM-279.raw SUBJECT_SAMPLE_FACTORS - WCF-223 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-223.raw SUBJECT_SAMPLE_FACTORS - WCF-226 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-226.raw SUBJECT_SAMPLE_FACTORS - WCF-227 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-227.raw SUBJECT_SAMPLE_FACTORS - WCF-228 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-228.raw SUBJECT_SAMPLE_FACTORS - WCF-229 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-229.raw SUBJECT_SAMPLE_FACTORS - WCF-230 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-230.raw SUBJECT_SAMPLE_FACTORS - WCF-231 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCF-231.raw SUBJECT_SAMPLE_FACTORS - WCM-233 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-233.raw SUBJECT_SAMPLE_FACTORS - WCM-234 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-234.raw SUBJECT_SAMPLE_FACTORS - WCM-236 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-236.raw SUBJECT_SAMPLE_FACTORS - WCM-237 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-237.raw SUBJECT_SAMPLE_FACTORS - WCM-238 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-238.raw SUBJECT_SAMPLE_FACTORS - WCM-243 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-243.raw SUBJECT_SAMPLE_FACTORS - WCM-246 BPS Treatment:Control | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WCM-246.raw SUBJECT_SAMPLE_FACTORS - WHF-295 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-295.raw SUBJECT_SAMPLE_FACTORS - WHF-297 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-297.raw SUBJECT_SAMPLE_FACTORS - WHF-298 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-298.raw SUBJECT_SAMPLE_FACTORS - WHF-299 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-299.raw SUBJECT_SAMPLE_FACTORS - WHF-306 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-306.raw SUBJECT_SAMPLE_FACTORS - WHF-307 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-307.raw SUBJECT_SAMPLE_FACTORS - WHF-4413 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4413.raw SUBJECT_SAMPLE_FACTORS - WHF-4415 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4415.raw SUBJECT_SAMPLE_FACTORS - WHF-4416 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4416.raw SUBJECT_SAMPLE_FACTORS - WHF-4417 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4417.raw SUBJECT_SAMPLE_FACTORS - WHF-4418 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4418.raw SUBJECT_SAMPLE_FACTORS - WHF-4419 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4419.raw SUBJECT_SAMPLE_FACTORS - WHF-4438 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHF-4438.raw SUBJECT_SAMPLE_FACTORS - WHM-289 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-289.raw SUBJECT_SAMPLE_FACTORS - WHM-290 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-290.raw SUBJECT_SAMPLE_FACTORS - WHM-294 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-294.raw SUBJECT_SAMPLE_FACTORS - WHM-300 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-300.raw SUBJECT_SAMPLE_FACTORS - WHM-301 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-301.raw SUBJECT_SAMPLE_FACTORS - WHM-304 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-304.raw SUBJECT_SAMPLE_FACTORS - WHM-305 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-305.raw SUBJECT_SAMPLE_FACTORS - WHM-4423 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4423.raw SUBJECT_SAMPLE_FACTORS - WHM-4427 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4427.raw SUBJECT_SAMPLE_FACTORS - WHM-4431 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4431.raw SUBJECT_SAMPLE_FACTORS - WHM-4432 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4432.raw SUBJECT_SAMPLE_FACTORS - WHM-4433 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4433.raw SUBJECT_SAMPLE_FACTORS - WHM-4434 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4434.raw SUBJECT_SAMPLE_FACTORS - WHM-4452 BPS Treatment:5mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WHM-4452.raw SUBJECT_SAMPLE_FACTORS - WLF-258 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-258.raw SUBJECT_SAMPLE_FACTORS - WLF-261 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-261.raw SUBJECT_SAMPLE_FACTORS - WLF-262 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-262.raw SUBJECT_SAMPLE_FACTORS - WLF-263 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-263.raw SUBJECT_SAMPLE_FACTORS - WLF-264 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-264.raw SUBJECT_SAMPLE_FACTORS - WLF-266 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-266.raw SUBJECT_SAMPLE_FACTORS - WLF-267 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLF-267.raw SUBJECT_SAMPLE_FACTORS - WLM-247 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-247.raw SUBJECT_SAMPLE_FACTORS - WLM-252 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-252.raw SUBJECT_SAMPLE_FACTORS - WLM-253 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-253.raw SUBJECT_SAMPLE_FACTORS - WLM-255 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-255.raw SUBJECT_SAMPLE_FACTORS - WLM-275 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-275.raw SUBJECT_SAMPLE_FACTORS - WLM-278 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-278.raw SUBJECT_SAMPLE_FACTORS - WLM-279 BPS Treatment:0.05mg/kg/d | Sample source:White Adipose Tissue RAW_FILE_NAME(Raw filename)=WLM-279.raw #COLLECTION CO:COLLECTION_SUMMARY After three weeks of feeding, adaptive feed was given for one week, followed by CO:COLLECTION_SUMMARY high-fat feed for eight weeks. The method of euthanasia for mice caused by CO:COLLECTION_SUMMARY cervical dislocation. Take the heart, liver, pancreas, white fat and brown fat CO:COLLECTION_SUMMARY of mice. After sampling, quickly rinse the tissue with normal saline. The CO:COLLECTION_SUMMARY cleaned tissues were treated with liquid nitrogen and finally frozen in a -80℃ CO:COLLECTION_SUMMARY refrigerator. CO:SAMPLE_TYPE White adipose,Brown adipose,Heart,Liver,Pancreas #TREATMENT TR:TREATMENT_SUMMARY Simply put, C57BL/6 pregnant mice were fed a normal diet under constant TR:TREATMENT_SUMMARY temperature [(23±1) ℃] and constant humidity [(55±5)%] conditions, and TR:TREATMENT_SUMMARY strictly followed a 12-hour / 12-hour light-dark cycle. In the experiment, the TR:TREATMENT_SUMMARY animals were kept in polystyrene mouse cages. Mice were divided into the normal TR:TREATMENT_SUMMARY saline solvent control group, the low-dose BPS group (0.05 mg/kg/d), and the TR:TREATMENT_SUMMARY high-dose BPS group (5 mg/kg/d). BPS exposure is performed through subcutaneous TR:TREATMENT_SUMMARY injection. Observe the general condition of pregnant mice every day and measure TR:TREATMENT_SUMMARY their weight once a week. After delivery, pregnant mice in different groups were TR:TREATMENT_SUMMARY exposed to BPS during lactation, and the female mice were sacrificed after TR:TREATMENT_SUMMARY lactation. After lactation, observe the general condition of F1 mice every day TR:TREATMENT_SUMMARY and weigh them once a week. After three weeks of feeding, adaptive feed was TR:TREATMENT_SUMMARY given for one week, followed by high-fat feed for eight weeks. Collect the TR:TREATMENT_SUMMARY hearts, livers, pancreas, white fat and brown fat of mice. After sampling, the TR:TREATMENT_SUMMARY mice were quickly washed with normal saline. After cleaning, the mice were TR:TREATMENT_SUMMARY treated with liquid nitrogen and finally frozen in a refrigerator at -80℃. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Each repeated mouse tissue sample (~15 mg) was precisely weighed and transferred SP:SAMPLEPREP_SUMMARY to 2 mL Eppendorf centrifuge tubes. Subsequently, magnetic beads and 400 μL of SP:SAMPLEPREP_SUMMARY pre-cooled methanol solution containing internal standards were added in SP:SAMPLEPREP_SUMMARY sequence. Internal standards was added, consisting of 1 μg/mL FFA (C16:0)-d3 SP:SAMPLEPREP_SUMMARY and FFA (C18:0)-d3, 1.63 μg/mL LPC (19:0) ,1.30 μg/mL SM (d18:1/12:0), 1.88 SP:SAMPLEPREP_SUMMARY μg/mL PC (38: 0),1.38 μg/mL PE (30:0), 1.26 μg/mL TG (45:0), and 1.27 μg/mL SP:SAMPLEPREP_SUMMARY Cer (d18:1/17:0). Then, tissue homogenization was performed at 65 Hz for 1 SP:SAMPLEPREP_SUMMARY minute using a high-throughput rapid grinder. The mouse heart, liver and SP:SAMPLEPREP_SUMMARY pancreatic tissues were ground and homogenized twice. The white fat and brown SP:SAMPLEPREP_SUMMARY fat of mice were ground and homogenized four times. After grinding is completed, SP:SAMPLEPREP_SUMMARY add 1mL of pre-cooled methyl tert-butyl ether to a centrifuge tube, vortex and SP:SAMPLEPREP_SUMMARY mix for 30 seconds first. Then, use a constant temperature mixer set to 10℃ SP:SAMPLEPREP_SUMMARY and vortex at 1000 rpm for 30 minutes. Subsequently, add 400 μL of pre-cooled SP:SAMPLEPREP_SUMMARY ultrapure water, continue to vortex and mix for 1 minute, and let it stand at SP:SAMPLEPREP_SUMMARY 6℃ for 5 minutes. The upper and lower phases were stratified by centrifugation SP:SAMPLEPREP_SUMMARY (15000 g, 15 min, 6℃). Collect the upper hydrophobic phase into 1.5 mL SP:SAMPLEPREP_SUMMARY Eppendorf centrifuge tubes, then place the samples in a freeze vacuum SP:SAMPLEPREP_SUMMARY centrifugal concentrator for low-temperature drying treatment. Finally, store SP:SAMPLEPREP_SUMMARY the obtained samples in a -80°C refrigerator for subsequent analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_SUMMARY Positive CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Thermo Dionex Ultimate 3000 CH:COLUMN_NAME Waters ACQUITY UPLC BEH C8 (100 x 2.1 mm, 1.7 μm) CH:SOLVENT_A 60% Acetonitrile/40% Water; 10 mM Ammonium Acetate CH:SOLVENT_B 90% Isopropyl alcohol/10% Acetonitrile; 10 mM Ammonium Acetate CH:FLOW_GRADIENT First, maintain 32% B for 1.5 minutes, then linearly increase it from 1.5 to CH:FLOW_GRADIENT 15.5 minutes to 85% B, then linearly increase it to 97% B within 0.1 minutes, CH:FLOW_GRADIENT maintain it until 18 minutes, and finally rapidly decrease it to 32% B at 0.1 CH:FLOW_GRADIENT minutes, and equilibrium until the next injection. CH:FLOW_RATE 0.26 mL/min CH:COLUMN_TEMPERATURE 55°C #ANALYSIS AN:ANALYSIS_TYPE MS AN:OPERATOR_NAME Shuyin Li AN:DETECTOR_TYPE Q-Exactive，Thermo Fisher，USA AN:SOFTWARE_VERSION Trace Finder(Thermo, USA) AN:DATA_FORMAT txt #MS MS:INSTRUMENT_NAME Thermo Q Exactive HF-X Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS MS acquisition Comments: Lipidomics analysis was performed using UPLC-MS with MS:MS_COMMENTS electrospray ionization (ESI) in both positive and negative ion modes. The spray MS:MS_COMMENTS voltage was 3.5 kV, and the capillary temperature was 325°C. For lipidomics, MS:MS_COMMENTS the normalized collision energy (NCE) was 15, 30, and 45, with a collision gas MS:MS_COMMENTS (not specified) used for fragmentation. Sheath gas flow was 50 arb, and MS:MS_COMMENTS auxiliary gas flow was 15 arb. The scan range was 150–2000 m/z, with a mass MS:MS_COMMENTS resolution of 140000 for full scan MS and 35000 for ddMS². For proteomics, the MS:MS_COMMENTS ion source parameters included a spray voltage, and fragmentation was performed MS:MS_COMMENTS using higher-energy collisional dissociation (HCD) with relevant collision MS:MS_COMMENTS energies. Data processing Comments: Lipid data processing involved peak MS:MS_COMMENTS extraction, noise removal, and normalization using Trace Finder 5.1 software. MS:MS_COMMENTS Protein data was processed using Proteome Discoverer version 2.5 for database MS:MS_COMMENTS searching, protein identification, and quantitation. Statistical analyses (e.g., MS:MS_COMMENTS PLS-DA, HCA) were conducted using Simca-P, MeV, and R.4.3.2 software. Lipid MS:MS_COMMENTS identification relied on databases like MS-DIAL and LipidMaps, with criteria MS:MS_COMMENTS including mass accuracy (±5 ppm for lipids), retention time, and characteristic MS:MS_COMMENTS fragments. Software/procedures used for feature assignments: Lipidomics: MS:MS_COMMENTS MS-DIAL, LipidSearch™ (Thermo Fisher Science, USA), Trace Finder 5.1, Simca-P, MS:MS_COMMENTS MeV, and MATLAB (for data processing and statistical analysis). Proteomics: MS:MS_COMMENTS Proteome Discoverer version 2.5 (for database searching and quantitation), MS:MS_COMMENTS DAVID, KOBAS3.0 (for functional enrichment), and R.4.3.2 (for statistical MS:MS_COMMENTS analysis). Identification procedures involved matching mass spectra to MS:MS_COMMENTS databases, verifying retention time rule, and analyzing fragmentation patterns. MS:CAPILLARY_TEMPERATURE 325℃ MS:COLLISION_ENERGY 15, 30, 45 MS:ION_SPRAY_VOLTAGE 3.5 kV MS:MS_RESULTS_FILE ST004034_AN006671_Results.txt UNITS:Peak area Has m/z:Yes Has RT:Yes RT units:Minutes #END